猪基因组信息资源的 整合与利用
DESCRIPTION
猪基因组信息资源的 整合与利用. 亓小红 天津农学院. 猪是人类最早驯化的家畜之一,作为世界的一个重要畜种,在地球上的分布很广。 世界范围内的猪肉消费量占红肉消费量的 43%(Rothscild and Ruvinsky,1998) 。 在我国肉类消费中,猪肉所占比例 67%(FAO, 2001) 。 研究人类疾病理想的实验动物模型和人类器官移植的供体。. 育种任务. 胴体品质好 肉质好 生长快 饲料消耗低 繁殖率高 抗病. 群体遗传学和数量遗传学理论的指导。 - PowerPoint PPT PresentationTRANSCRIPT
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43%(Rothscild and Ruvinsky,1998)67%(FAO, 2001)
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BLUP
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(Linkage Map (Physical Map QTLPigQTLdb(Comparative Map)ESTSNP
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Linkage MapsArchibald ,1995; Rohrer,1996AFLPSNP 5000
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Loci / Markers Publications / AuthorsClones Libraries Database Statistics
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SW2073Primer Information Forward primer:ATTTGCATAATAGCCTTATCCCTAC Reverse primer:CAATTTTATATGCACAGATTTATTTAAAGPCR product size:133-148 (bp), Sus scrofaGenBank Accession:AF253788
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Physical Maps4000EST
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Drawings of genes and markers mapped on pig chromosome List of genes mapped on pig map List of genetic markers mapped on pig map
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Comparative mapsThe Comparative Map: Pigs and Humans INRA(Inland Northwest Research Alliance ) The Comparative Map: Pigs and Mouse - Japan The Mammalian Comparative Map - Jackson Lab The HomoloGene Database - NCBI
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EST98988cDNA,.DNA.
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SNP(NEW)AlleleChromosomeBase PositionFunctionGene NameProtein Heterozygosity
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QTL-- PigQTLdbQTLQTLQTL10QTL862351129QTL
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QTLQTLQTL
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QTL on Pig Chromosome 1
Legend: Red QTL lines represent for significant and light blue QTL lines for suggestive levels. Green dots shows the position of QTL peaks. QTL\
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Number of QTL by chromosomesClick on each link to go to each chromosome for QTL on it.
Chromsome QTLs FoundX471150211335041865366141715386992510211119122413441448153116917181815
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Number of QTL by trait typesClick on each trait name to find QTL for it
Trait TypesQTLs FoundAnatomy367Behavioral22Chemical11Coat_color2Conductivity22Conformation8Digestive Organ9Disease Resistance6Endocrine4Enzyme Activity1Fat Composition40Fatness302Feed Conversion5Feed Intake11Flavor12Growth184Immune Capacity8Litter Size20Meat_color41Odor5PH38Reproductive Organ28Reproductive Traits9Stiffening3Texture40
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Number of QTL by trait classesClick on each trait class assiciated QTL
Trait ClassQTLs FoundExterior32Health14Meat Quality882Production209Reproduction61
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QTLQTLLD
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QTLQTN MAS
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1the porcine pituitary-specific transcription factor PIT-1) NAminopeptidase NAMPEPN 4melanocortin 4 receptor MC4R)(Kim et al. 2000)
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HALRNRNpH15DNARNRNAMPAMP-activated protein kinasesPRKA) adipocyte fatty acid-binding protein (A-FABP) IGF2
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ESR1.15 0.42retinoic acid receptor gammaRARG) 1Amelatonin receptor 1A MTNRIA) follicle stimulating hormone beta FSHB) prolactin receptor PRLR) 4retinol binding protein 4RBP4) phosphoglycerate kinase 2 PGK2)
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KIT ( ) 1melanocortin 4 receptor MC1R),
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NRAMP 12-(FUT1FUT2)F18K88acR133E. coli F4ab/acSLA
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2n=38310-9bpDNAcDNA)ESTEST
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NorthernDDRT-PCRPCR
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MAS (GAS)QTL MSEBV MSEBVI=b1MS+b2EBV
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Plastow (2003)15
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,,MAS,
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,
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QTL
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MAS
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