edition. · as η 2 to η 7 systems. synthesis, properties and nature of bonding in pi complexes....

1

Scheme of studies for M. Phil in Analytical & Inorganic Chemistry, Physical Chemistry, Organic chemistry and Biochemistry, 2016 & onward session

Summary Areas of Specializations

1. Analytical & Inorganic Chemistry 2. Physical chemistry. 3. Organic chemistry 4. Biochemistry

Course Work: 24 Credit Hours Semester Courses/Credits Total First 4 courses, 3 credits each 12 Second 4 courses, 3 credits each 12 Third and Fourth Research/Thesis 06 Total Credits 30

In addition to the course work and thesis, each student will have to give two seminars in fourth semester. Each student will present a literature survey report in the beginning of third semester related to his/her area of research.

The course work will be completed in first and second semesters where as research/ thesis will be completed in third and fourth semesters.

Course description of Analytical & Inorganic Chemistry

Semester I: Total credit: 12

Course Code Course Title

Credits

CHEM-701

Environmental Analysis 3

CHEM-702

Electro-analytical Techniques 3

CHEM-703

Chromatographic Techniques-I 3

CHEM-704

Spectroscopic Techniques-I 3

CHEM-705

Chemistry of Main Group Elements 3

CHEM-706

Organo-transition Metal Chemistry 3

CHEM-707

Medicinal Uses of Transition Metals/Inorganic Compounds 3

CHEM-708

Modern Inorganic Chemistry 3

2 Total Credits 12* *A student may opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours

List of Courses for Analytical & Inorganic Chemistry: 1. CHEM-701 Environmental Analysis Introduction, General principles and Techniques. Soil, sludge, sediment and dust analysis.

Analysis of plant Material, Analysis of Atmospheric Samples, Analysis of Water determination of toxic organic Chemistry. Analysis of toxic heavy metals. Biological indicators, Echo toxicology.

Recommended Books 1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel

Dekker, New York. 2. Christian, G.D. 2010. Analytical Chemistry. 6th Edition. John Wiley & Sons, Inc.

Singapore. 3. Skoog D.A. Holler, F.J and Nieman, T.A. 1998. Principles of Instrumental Analysis. 5th

Edition. Harcourt Asia PTE, Ltd. 4. Fifield, F.W and Kealey, D. 2000. Principles and Practice of Analytical Chemistry. 5th

Edition, Wiley-Blackwell. 5. Fifield, F.W and Haines, P.J.(Eds.) 2000. Environmental Analytical Chemistry. 2nd Edition.

Wiley-Blackwell. 6. Harris, D.C. 2006. Quantitative Chemical Analysis. 7th Edition. Freeman W. H. & Company,

New York. 2. CHEM-702 Electroanalytical Techniques Polarography and Amperometric Techniques:Basic principle, Instrumentation including various

electrodes, Modes of operation uses in polarography, Applications of polarography in Analytical Chemistry, Basic principle of Amperometric and Instrumentation. Voltammetric techniques: Instrumentation, Linear Potential Sweet (DC) Voltammeter, Potential Methods, Phase-Sensitive Alternating current Voltammeter, Stripping Voltammeter, Qualitative and Quantitative aspects of Voltammeter.

Recommended Books 1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel



Edition. Harcourt Asia PTE, Ltd.

http://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerankhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christian

3 4. Fifield, F.W and Kealey, D. 2000. Principles and Practice of Analytical Chemistry. 5th



New York. 3. CHEM-703

ChromatographicTechniques-I Introduction, theory, instrumentation and Applications of High Performance Liquid

Chromatography, Gas Chromatography-Mass spectrometry and Supercritical Fluid Chromatography.

Recommended Books 1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel Dekker,

New York. 2. Christian, G.D. 2010. Analytical Chemistry. 6th Edition. John Wiley & Sons, Inc.





New York. 4. CHEM-704 Spectroscopic Techniques-I NMR spectroscopy, Raman spectroscopy, Mass spectrometry, IR spectroscopy Recommended Books 1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel





Wiley-Blackwell.

http://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerankhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerankhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerank

4 6. Harris, D.C. 2006. Quantitative Chemical Analysis. 7th Edition. Freeman W. H. and

Company, New York. 5. CHEM-705 Chemistry of Main Group Elements Introduction, Preparation, Classes of Nucleophilic Organometallic Reactions. Organo-Li, Se, Si,

Sn, Sb and Zn in Organic Synthesis. Control Side Reactions (Enolization vs. Nucleophilic Addition, Substitution vs. Elimination, Selectivity among functional Groups via Organometallic Reagents)

Recommended Books 1. Miessler, G.L. Fischer, P.J and Tarr, D.A. 1991. Inorganic Chemistry. Prentice-Hall

International, Inc. 2. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders

College Publishing. 3. Sharpe, A.G. 1992. Inorganic Chemistry. Longman Group Limited. 4. Alexander, D.G and Boris I.K. 2003. Synthetic, Coordination and Organometallic Chemistry.

Marcel Dekker, Inc. New York. 5. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders

College Publishing. 6. Atkins, P.W. Langford, C.H and Shriver, D.F. 1994. Inorganic Chemistry. 2nd Edition.

Oxford University Press. 6. CHEM-706 Organo-transition Metal Chemistry Introduction, History, Nomenclature, Classification of Organometallic Compounds, Transition

Metal to Carbon Sigma bonded Compounds. Compounds with Metal-Carbon pi-bonds such as η2 to η7 Systems. Synthesis, Properties and nature of bonding in pi Complexes. Experimental Techniques used in synthesis and characterization, Fundamental process in organometallics synthesis; Applications of organometallics in medicines and industry

Recommended Books 1. Yamamoto, A. 1986. Organotransition Metal Chemistry; Fundamental Concepts and

Applications. John Wiley & Sons, New York. 2. Callister, W.D. 2003. Material Science and Engineering; An Introduction. John Wiley, New

York. 3. Weight, J.D and Nico A.J.M. 2001. Sol-gel Material Chemistry and Application.

Sommerdijk, Taylor and Francis Books Ltd. 4. Rao C.N.R. 1993. Chemistry of Advanced Materials. Oxford Blackwell Scientific

Publications. 5. Atkins P.W. Langford, C.H and Shriver, D.F. 1994. Inorganic Chemistry. 2nd Edition. Oxford

University Press. 7. CHEM-707 Medicinal Uses of Transition Metals/Inorganic Compounds Role of Micro-nutrient Elements in Human Body, Metal Bearing Enzymes and their Functions.

Adverse Effects of Excess/Deficiency of Micro-nutrients. Use of Transition Elements and

5

their Inorganic Compounds in Diagnosis and Treatment of various diseases. Metal Based Drugs, Importance of Metals and Non-metals in Biological systems. Metal ion and Chelating agents for medicinal purposes.

Recommended Books

1. Keppler, B.K. 1993. Metal Complexes in Cancer Chemotherapy. VCH, Weinheim, Germany. 2. Farrell, N. 2002. Coordination Chemistry Reviews. Elsevier Publishing Company. 3. Schwietert, C.W and McCue, J.P. 1999. Coordination Chemistry Reviews. Elsevier

Publishing Company. 4. Dabrowiak, J.C. 2009. Metals in Medicine. John Wiley & Sons Ltd. UK. 8. CHEM-708

Modern Inorganic Chemistry Periodic Table (trends, anomalies, application, and nomenclature). Extraction of metals (Cu, Ag, Au, U etc) from ores, purification (Modern Trends). Metallic Corrosion: (Classification, Theories, latest trends in prevention. Inorganic rings, cages & Clusters: Structure, preparation & applications. Fuel cells Recommended Books

1. Lee, J.D. 1999. Concise Inorganic Chemistry. Wiley. 2. Atkins P.W. Langford, C.H and Shriver, D.F. 1994. Inorganic Chemistry. 2nd Edition. Oxford

University Press. 3. Sienko, M. J and Plane, R.A. 1989. Chemistry: Principles and Properties, McGraHill Book

Company Incorporated. 4. Huheey, J.E. 1983. Inorganic Chemistry: Principles of Structure and Reactivity, 3rd Edition.

Harper & Row, New York. 5. Shriver D. F and Atkins, P .W. 1999. Inorganic Chemistry, 3rd Edition. Oxford University

Press. 6. Shriver, D.F. Kaesz, H.D and Adams, R.D. 1990. The Chemistry of Metal Cluster

Complexes. VCH. 7. Kauzlarich, S.M. 1996. Chemistry Structure and Bonding of Zintl Phases & Ions. VCH. 8. Housecroft, C.E. 1990. Boranes & Metalloboranes. Wiley. 9. Mingos, D.M.P and Wales, D.J. 1990. Introduction to Cluster Chemistry. Prentice Hall. 10. Ormerod, R.M. Solid Oxide Fuel cells; Chemical Society Reviews. Royal Society of

Chemistry. 11. Choy, K.L. 2003. Chemical Vapour Deposition of Coatings; Progress in Materials Science,

Pergamon. Semester II Total credit: 12


Credits

CHEM-709

Chromatographic Techniques-II 3

CHEM-710

Spectroscopic Techniques-II 3

6 CHEM-711

Thermal Methods of Analysis 3

CHEM-712

Inorganic and Organometallic Polymers 3

CHEM-713

Applied Transition Metal Chemistry 3

CHEM-714

Inorganic Material Chemistry (II) 3

CHEM-715

Advanced Practicals in analytical & inorganic Chemistry 3

CHEM-716

Solid State Chemistry 3

CHEM-717

Recent Advances in Metal Based Drugs 3

CHEM-718

Experimental Techniques in Coordination & Organometallic Chemistry

3

Total Credits 12* *A student can opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours

List of Courses for Analytical & Inorganic Chemistry: 1. CHEM-709 Chromatographic Techniques-II Introduction, theory, instrumentation and applications of Ion & Ion-Exchange Chromatography,

Molecular Exclusion Chromatography, Affinity Chromatography, Electrophoresis, HPTLC Recommended Books 1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel





Wiley-Blackwell. 6. Harris, D.C. 2006. Quantitative Chemical Analysis. 7th Edition. Freeman W. H. and

Company, New York. 2. CHEM-710

http://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerank

7 Spectroscopic Techniques-II Atomic absorption spectroscopy, Atomic emission Spectroscopy, X-ray spectroscopy, Inductive

coupled plasma Spectroscopy, Nephelometry, Laser spectroscopy, Luminescence spectroscopy.


New York. 2. Christian, G.D. 2010. Analytical Chemistry. 6th Edition. John Wiley & Sons, Inc. Singapore. 3. Skoog D.A. Holler, F.J and Nieman, T.A. 1998. Principles of Instrumental Analysis. 5th




Company, New York. 3. CHEM-711 Thermal Methods of Analysis Introduction to Thermogravimetry, Types of thermobalances, factors affecting TG curves,

sources of error, applications of TGA, DTA and DSC; theory, instrumentation, factors affecting DTA curves, Quantitative analysis, applications.






Company, New York. 4. CHEM-712 Inorganic and Organometallic Polymers Introduction to Inorganic and Organometallic Polymers, Synthetic Strategies, Cyclo and

polyphosphazines, Cyclo polyphosphazines containing polymers (Introduction, historical, synthesis and applications), Phosphorous, Sulphur and Boran containing polymers(Introduction, historical, synthesis, applications and latest developments), Polysiloxanes (Introduction, historical, synthesis , applications latest developments latest

http://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerankhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerank

8

developments) Polysiloxanes and other Silicon containing polymers (Introduction, historical, synthesis, applications & latest developments)


International, Inc. 2. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders College

Publishing. 3. Sharpe, A.G. 1992. Inorganic Chemistry. Longman Group Limited. 4. Alexander, D.G and Boris I.K. 2003. Synthetic, Coordination and Organometallic Chemistry.

Marcel Dekker, Inc. New York. 5. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders College

Publishing. 6. Atkins, P.W. Langford, C.H and Shriver, D.F. 1994. Inorganic Chemistry. 2nd Edition.

Oxford University Press. 5. CHEM-713 Applied Transition Metal Chemistry Ziegler-Natta and Wacker catalyst, Polymerizatio and Oligomerization of Ethylene, Propylene,

Olefins, Cyclic Olefins and Alkynes. Fischer-Trosch Process, Oxidation Reaction, Synthesis of acrylates and Related Derivatives.


International, Inc. 2. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders College

Publishing. 3. Sharpe, A.G. 1992. Inorganic Chemistry. Longman Group Limited. 4. Alexander, D.G and Boris I.K. 2003. Synthetic, Coordination and Organometallic Chemistry.

Marcel Dekker, Inc. New York. 5. Purcell, K.F and Kortz, J.C. 1980. An Introduction to Inorganic Chemistry. Saunders

College Publishing. 6. Atkins, P.W. Langford, C.H and Shriver, D.F. 1994. Inorganic Chemistry. 2nd Edition.

Oxford University Press. 6. CHEM-714

Inorganic Material Chemistry (II) Introduction to material sciences, synthesis and design of inorganic materials, characterization

techniques. Inorganic-organic hybrid materials, zeolites. Intercalation in layer materials. Some recent development in inorganic material chemistry. Ordered Solids Including Interstitial Compounds. Alloys. Amorphous Solids (Glass and Polymers)

Recommended Books 1. Alexander D. G. and Boris I. K. 2003. Synthetic, Coordination and Organometallic

Chemistry, Marcel Dekker, Inc, New York . 2. Huheey J. E. 2006. Inorganic Chemistry Principles of Structure and Reactivity, Harper and

9

Row Publishers, SI Unit Edition. 7. CHEM-715

Advanced Practicals in analytical & inorganic Chemistry Practicals related to inorganic chemistry enabling the students to use the UV-Visible

spectroscopy, FTR, TGA, Atomic absorption spectroscopy, HPLC, CHN analyzer, GC-Ms etc Recommended Books

1. Robinson, J.W. 2005. Under Graduate Instrumental Analysis. 6th Edition. Marcel Dekker,





Company, New York. 8. CHEM-716 Solid State Chemistry Classification of Bonds and Crystals. The Effect of Radius Ratio and Charge on Creystals.

Application of Isoelectronic principle. Ordered solids Including Industrial Compounds, Alloys, Superclusters and Storage Batteries, Amorphous Solids (Glass and Polymres).

Recommended Books 1. Callister, W.D. 2003. Material Science and Engineering; An Introduction. John Wiley, New

York. 2. Weight, J.D and Nico A.J.M. 2001. Sol-gel Material Chemistry and Application.

Sommerdijk, Taylor and Francis Books Ltd. 3. Rao C.N.R. 1993. Chemistry of Advanced Materials. Oxford Blackwell Scientific

Publications. 4. Christian, G.D. 2010. Analytical Chemistry. 6th Edition. John Wiley & Sons, Inc.

Singapore. 5. Crabtree, R. H. 2005. The Organometallic Chemistry of Transition Metals. John Wiley &

Sons, New York. 9. CHEM-717 Recent Advances in Metal Based Drugs

http://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christianhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=F.+W.+Fifieldhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=David+Kealeyhttp://www.amazon.com/s/ref=dp_byline_sr_book_1?ie=UTF8&field-author=F.+W.+Fifield&search-alias=books&text=F.+W.+Fifield&sort=relevancerankhttp://www.amazon.com/s/ref=dp_byline_sr_book_2?ie=UTF8&field-author=P.+J.+Haines&search-alias=books&text=P.+J.+Haines&sort=relevancerankhttp://eu.wiley.com/WileyCDA/Section/id-302479.html?query=Gary+D.+Christian

10 Introduction to metal based pharmaceuticals, Historical perspective. Metal-based drugs as

general therapeutics, Metal based anticancer drugs; Platinum, Ruthenium, Gallium, Osmium, Copper, Tin, Titanium and gold based chemotherapeutics. Mode of action of metal based Drugs. Latest developments and strategies in chemotherapy, Structure activity relationships, Non- classical metal based drugs, Metal based drugs in diabetics and malaria, Antiviral and Anti-fungal agents, Metals base drugs as diagnostic tool (Ga, Cu, Mn, Tc, Re), Medicinal applications of ionic liquids. Recommended Books

1. Keppler, B.K. 1993. Metal Complexes in Cancer Chemotherapy. VCH, Weinheim, Germany. 2. Farrell, N. 2002. Coordination Chemistry Reviews. Elsevier Publishing Company. 3. Schwietert, C.W and McCue, J.P. 1999. Coordination Chemistry Reviews. Elsevier

Publishing Company. 4. Dabrowiak, J.C. 2009. Metals in Medicine. John Wiley & Sons Ltd. UK. 10. CHEM-718

Experimental Techniques in Coordination & Organometallic Chemistry Manipulation of air sensitive compounds , Characterization of organometallic & Coordination

compounds (Chemical analysis, IR & Raman spectroscopy, Molecular weight, X-ray diffraction & Neutron diffraction Analysis, Mass spectrometry, Visible and UV- spectroscopy, Mössbauer spectroscopy, Dipole-moment, Magnetic Susceptibility and ESR spectroscopy and NMR spectroscopy) Recommended Books

1. Hil, A.F. 2002. Organotransition Metal Chemistry. Royal Society of Chemistry, UK. 2. Yamamoto, A. 1986. Organotransition Metal Chemistry; Fundamental Concepts and

Applications. John Wiley & Sons, New York. 3. Alexander, D.G and Boris I.K. 2003. Synthetic, Coordination and Organometallic Chemistry.

Marcel Dekker, Inc. New York. Semester-III & IV Total Credit hour: 6 (Research/Thesis) The research scholars are supposed to carry out research on any specialized topic as assigned by the research supervisor throughout semester-III and IV. The comprehensive examination will held before the viva voce examination. It is essential to pass the comprehensive examination before appearing for the viva voce examination.

Course description of Physical Chemistry Semester-I Course Code Course Title Credit CHEM-720 Polymer and Advanced Composite Materials 3 CHEM-721 Advanced Quantum Chemistry 3 CHEM-722 Advanced Electrochemistry 3 CHEM-723 Advanced Reactions Dynamics 3 CHEM-724 Advanced Photochemistry 3 CHEM-725 Surface Chemistry 3 CHEM-726 Solution Chemistry 3

11 Total Credits 12 *A student may opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours

List of courses for Physical Chemistry Semester I 1. CHEM-720 Polymers and Advanced Composite Materials Cr. 03

High polymers, classification, Molecular forces and chemical bonding in polymers, configuration and conformation of polymer chains, theories of polymer solutions; phase separation and fractionation, plasticization, molecular size measurement, spectroscopic analysis, thermal analysis, morphology and order in crystalline polymers, polymer rheology, electrical and magnetic properties of polymers.

Recommended Books 1. Billmeyer F.W. Jr. 1984. Text Book of Polymer Science. John Willey and Sons, Inc. 2. Huggins, M.L. 1958. Physical Chemistry of High polymers. Wiley. 3. Rawe, A. 2000. Principles of polymer Chemistry. 2nd Edition. Plenum publishers, New York. 4. Fried, J.R. 1995. Polymer Science and Technology. Prentice Hall. 5. Burnett, G.M and Mark, H.F. 1954. Mechanism of Polymer Reactions. Interscience

Publishers, New York. 2. CHEM-721 Advanced Quantum Chemistry Cr. 03

Angular momentum. Central field problem. Variation and perturbation methods. Many electron atoms, molecules, self-consistent field method. Approximate methods in molecular quantum chemistry. Applications to quantum mechanical systems. Theoretical and computational approach. Basis sets and functionals. Density functional methods. Optimization and molecular modeling.

Recommended Books 1. Frank, J. 2007. Introduction to Computational Chemistry. John Wiley & Sons, England. 2. Grant, G. H and Richard, W.G. 1995. Computational Chemistry. Oxford Science

Publications. 3. Richard, G. 2000. Computer Simulations with Mathematics. Springer Verlag, Germany. 3. CHEM-722 Advanced Electrochemistry Cr. 03

Overview of electrochemistry, Concepts, electrical conductivity and interionic interactions, the electrical double layer and its structure, electrical potentials and electric current, thermodynamics of electrochemical reactions, kinetics of electrochemical reactions. Electrode and electrolytes: Working electrodes, Reference electrodes, electrolytes, electrochemical methods for the study of the electrode/electrolyte interface. Electroanalytical

12

techniques: Cyclic voltammetry, pulse voltammetry, square wave voltammetry, chronocoulometry, electrochemical impedance spectroscopy, UV/Vis/NIR spectroelectrochemistry, stripping voltammetry, electrochemical studies of solid compounds and materials, potentiometry. Applications: Potentiometric sensors, amperometric and voltammetric sensors, electrochemistry in industry, corrosion. Recommended Books

1. Bard, A.J. and Faulkner, L.R. 1993. Electroanalytical Chemistry. Marcel Dekker. 2. Pletcher, D. and Walsh, F.C. 1993. Industrial Electrochemistry. 2nd Edition. Blackie

Academic & Publisher. 3. Brett, C.M.A and Brett, A.M.O. 1993. Electrochemistry: Principles, Methods and

Applications. Oxford. 4. Mohammad, M and Amjad, M. 2000. Principles of Electrode Kinetics. Rooha Printers,

Lahore. 5. Scholz F.(Ed.) 2002. Electroanalytical Methods: Guide to Experiments and Applications.

Springer-Verlag, Berlin. 4. CHEM-723

Advanced Reactions Dynamics Cr. 03 Potential energy surfaces, statistical and quantum mechanical approaches for the study of unimolecular decomposition rate. Collision theory, transition state theory and microscopic reversibility, theories of termolecular reactions ,kinetics in liquid solutions, kinetics of fast reactions, molecular reaction dynamics, molecular beam method, linear free energy relationships, temperature effect, heat capacity of activation. Pressure effects and the volume of activation. Applications of transition state theory. Solvent effects, salt effects, kinetic isotope effects. Composite rate constants, isokinetic relationship. Extrakinetic probes of mechanism.

Recommended Books 1. Laidler, K.J and Meiser, J.H. 1998. Physical Chemistry. Benjamin/Cummings Publishing

Company, Inc. 2. Kaufman, E.D. 1966. Advanced Concepts in Physical Chemistry. McGraw Hill Book

Company. 3. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media (P)

Ltd. 4. Espenson, J.H. 1995. Chemical Kinetics and Reaction Mechanism. 2nd Edition. McGraw Hill,

New York. 5. CHEM-724 Advanced Photochemistry Cr. 03

Principle of photochemistry. Sources of radiation, actinometry (both physical and chemical), primary and secondary photochemical processes, quantum yields, experimental techniques, photolytic studies of aqueous and non-aqueous systems, effects of photoradiation on solids. Kinetics, mechanism and energetics of photochemical reactions.

Recommended Books

1. Richard, P.W. 1988. Principles and Applications of Photochemistry. Oxford University Press.

13 2. Valvert, J.G and Pitts J.N. 1966. Photochemistry. John Wiley & Sons, New York. 3. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media (P)

Ltd. 4. Atkins, P.W. 1998. Physical Chemistry. Oxford University Press. 5. Alberty, R. A and Silvey, R.J. 1992. Physical Chemistry. 7th Edition. John Wiley & Sons. 6. CHEM-725 Surface Chemistry Cr. 03

Adsorption systems. Discussion and comparison of various adsorption isotherms (Langmuir, Freundlich, Henry, Tempkin, Slygin-Frumkin and BET adsorption isotherm). Chemisorption and surface heterogeneity. Adsorption at liquid/gas interface, surface tension of solutions and surface excess amount. Gibbs adsorption isotherm. Potential theory of adsorption. Comparison of gas and vapor adsorption theories, Nature of surface bond. Conductivity measurements. Surface techniques, Field Emission Microscopy (FEM), Field Ion Microscopy (FIM), Low Energy Election Diffraction studies (LEED). Measurement of gas and vapor adsorption. Gas Chromatography coupled with Mass Spectrometry in the study of heterogeneous catalysis. Applications of radiotracers in catalysis.

Recommended Books 1. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media (P)

Ltd. 2. Rosen, M. J. 1989. “Surfactant and Interfacial Phenomena” Marcel Dekker Inc., New York. 3. Hiemenz, P.C and Rajagopalan, R. “Principle of Collides and Surface Chemistry” Marcell

Dekker Inc, New York. 4. Bond, G.C. 2004. Heterogeneous Catalysis. 5th Edition. Clarendon Press, Oxford 2004. 5. Thomson, S.J and Webb, G. 1969. Hetrogeneous Catalysis. Oliver & Boyd Publishing

Company. Adamson, A.W and Gast, A. 1999. Physical Chemistry of Surfaces. John Wiley.

7. CHEM-726 Solution Chemistry Cr. 03

Physicochemical characteristics of solvents. Solute-solvent interaction, solvation of ions, preferential solvation. Thermodynamic properties of solute in bare solvents and mixed solvents. Transport properties of solutions, concept of association constant of ions in solution. Study of solute-solvent-solute interactions by spectroscopic techniques.

Recommended Books

1. John, B. 1978. Metal Ions in Solution. Chichester Ellis Howard. 2. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media (P)

Ltd. 8. CHEM-727 Advanced Techniques in Physical Chemistry Cr. 03

Practicals related to Physical chemistry enabling the students to use the UV-Visible spectroscopy, FTR, TGA, Atomic absorption spectroscopy, HPLC, CHN analyzer, GC-Ms etc.

14

Recommended Books 1. Skoog, D.A. Holler, F.J and Stanley, R. 2006. Principles of Instrumental Analysis. 6th

Edition. 2. Ewing, G.W. 1985. Instrumental Methods of Chemical Analysis. 5th Edition. McGraw Hill,

New York. 9. CHEM-728

Nanomaterials Cr. 03 (New Course) Nanomaterials, Classification of nanomaterials: Manufacturing/synthesis process and Growth Mechanism, Properties of nanomaterials, Theory lorentz oscillator model, Mie theory readings, Flow behavior of nanoparticles, A brief intro to suspension rheology, Fullerenes, Graphenes, Carbon nanotubes, Quantum dots. Quantization of resistance, single electron transistors, Esaki and resonant tunneling diodes, Magnetoresistance, Spintronics, Semiconductor quantum dots, photonic crystal, metamaterials

Recommended Books

1. Cao, G and Wang, Y. 2011. Nanostructures and Nanomaterials: Synthesis Properties and Applications. World scientific publishing Co., London.

2. Schodek, D. Ashby, M.F and Ferreira, P.J. 2009. Nanomaterials, Nanotechnologies and Design. 1st Edition. Elsevier Publishers.

3. Singh, A.A. 2008. Nanofabrication, Fundamentals and Applications. 1st Edition. World Scientific Publishers, USA.

4. Wang, Z. L. 2000. Characterization of Nanophase Materials. 1st Edition. Willy-VCH. Germany.

10. CHEM-729 Physical Aspects of Environment Cr. 03

The nature and composition of human environment. The aquatic environment. Compellation in natural waters. The catalysis of aquatic reactions, liquid-solid gas interactions in aquatic chemistry, water pollution and trace-level substances in water. Water treatment. Environmental chemical and soil analysis. The nature and composition of the atmosphere. The oxides of carbon, sulphur and nitrogen in the atmosphere. Particulate matter and minor inorganic pollutants in the atmosphere, atmosphere, atmospheric monitoring and chemical toxicology. Human environment and its resources; resource depletion and environmental pollution. Interaction of pollutants with materials; noxious emissions from industrial processes, aerosol production. Chemistry of pollutants. Nuclear waste and its management. Kinetic and thermodynamic aspects of atmospheric phenomena. Clean energy for future experimental techniques for environmental monitoring. Recommended Books

1. Hiemenz, P.C and Rajagopalan, R. “Principle of Collides and Surface Chemistry” Marcell Dekker Inc, New York.

2. Johns, M.N. 1979. Biochemical Thermodynamics. Elsevier Scientific Publishing Company, Amsterdam- Oxford- New York.

3. Rosen, M. J. 1989. “Surfactant and Interfacial Phenomena” Marcel Dekker Inc., New York. 4. Scifullon, R.S. 1992. Physical Chemistry of Inorganic Polymeric Composite Materials. Ellis

Harwood. 5. Shalin, R.E. 1995. Polymer Matrix Composites. Chapman and Hall.

15

Wesly, W.E. Jr. 2000. Industrial Water Pollution Control. McGraw Hill, New York. Semester-II Course Code Course Title Credit

CHEM-730 Magnetic Spin Dynamics 3 CHEM-731 Advanced Molecular Spectroscopy 3 CHEM-732 Biophysical Chemistry 3 CHEM-733 Advanced Statistical Thermodynamics 3 CHEM-734

Chemistry of Polyoxometalates (POM) 3

CHEM-735 Colloids and Surfactants 3

CHEM-736 Nuclear Chemistry and Radiation Chemistry 3

CHEM-737

Advanced Solid State Chemistry and Characterization Techniques 3

CHEM-738 Heterogeneous Catalysis 3 CHEM-739 Ion Exchange Chemistry 3 A student can opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours.

List of courses for Physical Chemistry Semester II

*Courses will be offered depending on the availability and interests of the faculty. 1. CHEM-730

Magnetic Spin Dynamics Cr. 03 Spin and applied field, Spin and magnetic field, Larmor Precession, Relaxation mechanism, Dynamic Nuclear Magnetic Resonance, Application in structure elucidation, Chemical shift, coupling constant, coupling among several nuclei, chemical analysis by NMR, HNMR, CNMR, Quadrupole Effects, Technique and Instrumentation, Electron Spin resonance spectroscopy, Double resonance in ESR, Electron-Electron Coupling, ESR instrumentation. Recommended Books 1. Levitt, M.H. 2000. Spin Dynamics: Basics of Nuclear Magnetic Resonance. Wiley. 2. Keeler, J. 2003. Understanding NMR Spectroscopy. 2ndEdition. John Wiley & Sons. 3. Banwell, C.N and McCash, E.M. 1994. Fundamentals of Molecular Spectroscopy. 4th

Edition. McGraw Hill International Company, UK.

2. CHEM-731 Advanced Molecular Spectroscopy Cr. 03

http://www.google.com/search?tbo=p&tbm=bks&q=inauthor:%22Malcolm+H.+Levitt%22&source=gbs_metadata_r&cad=5http://www.google.com/search?tbo=p&tbm=bks&q=inauthor:%22James+Keeler%22&source=gbs_metadata_r&cad=8

16

Classification of spectroscopy. Rotational spectra of polyatomic molecules. Vibrations of polyatomic molecules (linear and symmetric top). Types of vibrational modes. Fermi resonance. The influence of Nuclear spin. Symmetry, Symmetry elements and operations, Point groups. FTIR, theory and applications including differences of FTIR and dispersive IR instruments. Applications of IR spectroscopy in structural chemistry. Electronic spectra of many electron atoms. Recommended Books 1. Kaufman, E.D. 1966. Advanced Concepts in Physical Chemistry. McGraw Hill Book

Company. 2. Laidler, K.J and Meiser. J.H. 1998. Physical Chemistry. Benjamin/Cummings Publishing

Company, Inc. 3. Banwell, C.N and McCash, E.M. 1994. Fundamentals of Molecular Spectroscopy. 4th

Edition. McGraw Hill International Company, UK. 4. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media

(P) Ltd. 5. Barrow, G. M. 1962. Introduction to Molecular Spectroscopy. McGraw Hill, New York.

3. CHEM-732 Biophysical Chemistry Cr. 03 (New Course) Introduction to biophysical chemistry, macromolecules, biopharmaceutics; enzymology and kinetics: metal based-enzymes, thermodynamics and interactions between the biomolecules, Oxidation/Reduction reactions and bioenergetics, Biophysical basis of separation, ultafilteration, dialysis, centrifugation, electrophoresis, Sedimentation), understanding biological system using physical chemistry(biochemical pathway for visual response, membrane potential , transporters and channels, photosynthesis),biophysical chemistry of interface, radioactivity and its effect on human body. Recommended Books 1. Coope, A. 2011. Biophysical Chemistry. 2nd Edition. RSC Publisher. 2. Ohshima, H. 2011. Biophysical Chemistry of Biointerfaces. 2nd Edition. Wiley. 3. Allen, J.P. 2009. Biophysical Chemistry. 2nd Edition. Blackwell Publisher. 4. Das, D. 2007. Biophysics & Biophysical Chemistry. 5th Edition. Academic Publisher.

4. CHEM-733 Advanced Statistical Thermodynamics Cr. 03 Ensembles, microcanonical, canonical and grand canonical. Average values, fluctuations. Partition functions of diatomic and polyatomic gases. Statistical mechanical treatment of chemical processes and equilibria. Imperfect gases, liquid state, dilute solutions and perfect crystals. Applications of Fermi-Dirac and Bose-Einstein statistics. Recommended Books 1. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media

(P) Ltd. 2. Sears, F.W and Salingers, G.L. 1975. Thermodynamics, Kinetic Theory and Statistical

Thermodynamics. 3rd Edition. John Wiley. 3. Roy, B. N. 2002. Fundamentals of Classical and Statistical Thermodynamics. John Wiley.

17 5. CHEM-734 (New Course)

Chemistry of Polyoxometalate (POM) Cr. 03 Polyoxometalate. Histrory, structure, topology and framework. POM-based organic−inorganic hybrid composites. Functionalization of Hexamolybdates (POM). Stability. General Context and Concept of second-order non-linear optics (NLO). Quantum Chemical Approach, NLO Properties of POM-based hybrid materials. Polyxometalate-Protected Nanoparticles: Synthesis, Structure and Catalysis. Applications of POM. Recommended Books 1. Janjua, M.R.S.A. 2013. Quantum Mechanical Study of NLO Properties in Hybrid

Composites. Scholars' Press, Heinrich-Bcking-Str. 6-8, 66121, Saarbrcken, Germany. 2. Janjua, M.R.S.A. Mahmood, A and Ahmad, T. 2013. Quantum Chemical Perspective of

NLO Properties of Ruthenium Complexes. LAMBERT Academic Publishers, Heinrich-Bcking-Str. 6-8, 66121, Saarbrcken, Germany.

3. Pope , M.T and Müller, A. 2001. Polyoxometalate Chemistry From Topology via Self-Assembly to Applications. ISBN: 978-0-7923-7011-6 (Print)

4. Sécheresse, F. 2013. Polyoxometalate Chemistry: Some Recent Trends. World Scientific, New Jersey.

6. CHEM-735 Colloids and Surfactants Cr. 03 Liquid interfaces, surface tension and adsorption from solution, insoluble surface monolayer (Langmuir-Blodgett films). Surfactant, detergency, organized molecular assemblies (micelles, vesicles and membranes). Micro and macro emulsions. Colloidal dispersions, coagulation and flocculation. Optical properties of colloids. Recommended Books 1. John, B. 1978. Metal Ions in Solution. Chichester Ellis Howard. 2. Gurdeep, R. 2008. Advanced Physical Chemistry. 3rd Edition. Krishna Prakashan, Media

(P) Ltd.

http://www.worldscientific.com/doi/suppl/10.1142/8749/suppl_file/8749_chap01.pdfhttp://www.worldscientific.com/doi/suppl/10.1142/8749/suppl_file/8749_chap01.pdfhttp://link.springer.com/search?facet-author=%22Michael+T.+Pope%22http://link.springer.com/search?facet-author=%22Achim+M%C3%BCller%22

18

7.

CHEM-736 Nuclear Chemistry and Radiation Chemistry Cr. 03 Nuclear Chemistry, Principles, sources of nuclear radiation. Nuclear track detectors. Kinetics and mechanism of track etching. Nuclear materials. Nuclear techniques. Tracers. Radiation Chemistry, theoretical aspects. Various models. Kinetic studies of radiolytic processes. Dosimetry (physical and chemical). Radiation chemical yields. Dose and dose rate effects on primary and secondary products. Steady state and pulse radiolysis techniques. Radiolytic studies of gaseous, water, aqueous and organic systems. Radiology. Recommended Books 1. Spinks, J.W.T and Woods, R.J. 1976. An introduction to Radio Chemistry. 2nd Edition.

John Wiley, New York.

2. Choppin, G.R and Jan Rayberg. 1998. Nuclear Chemistry Theory and Application. 1st Edition. Pergamon Press, Oxford, New York.

3. Friendler, G and Kennedy, J.W. 1981. Nuclear and Radiochemistry. 3rd Edition. John Wiley & Sons, New York.

4. Pikave, A. K and Woods, R. J. 1994. Applied Radiation Chemistry. Wiley, New York.

5. Rodgers, F.A.J. 1987. Radiation Chemistry: Principles and Applications. VCH, New York.

6. Spinks, S.W.T and Woods, R.J. 1990. An Introduction to Radiation Chemistry. Wiley, New York.

8. CHEM-737 Advanced Solid State Chemistry and Characterization Techniques Cr.03 Solid state, metal conductors, band theory, semiconductors, insulators, work function, electrochemical potential and fermi levels, super conductivity: recent theories, preparation and characterization of super conducting ceramics and their electrical and magnetic properties. Recommended Books 1. Anthony, R.W. 2004. Solid State Chemistry and its Application. Wiley Student Edition.

John Wiley & Sons. 2. Knauth, Philippe/Di Vona, Luisa, M. 2012. Solid State Proton Conductors. John Wiley &

Sons. 3. Smart, L.E and Moore, E.A. 2012. Solid State Chemistry: An Introduction. 4th Edition.

CRC Press. 9. CHEM-738

Heterogeneous Catalysis Cr. 03 (New Course) Rates of surface reaction. Discussion on rate expressions for unimolecular and bimolecular reactions. The Langmuir-Hinshelwood and Rideal-Eley Mechanism. Specific rate of catalytic reactions with typical examples. Comprison between catalytic reaction with homogeneous reaction. The exchange of saturated hydrocarbons. The stereochemistry of exchange reactions. Exchange reactions involving bonded intermediates. Metal catalysed hydrogenation of unsaturated and diunsaturated hydrocarbons. The mechanism of alkylne hydrogenation. Surface reactions on oxides, Hydrodesuphurisation reactions. Recommended Books 1. Rideal, E.K. 1968. Concepts in Catalysis. Academic Press London.

19

2. Thomas, J.M and Thomas, W.J. 1967. Introduction to the Principle of Heterogeneous Catalysis. Academic press London.

3. Thomson, S.J and Webb, G. 1969. Hetrogeneous Catalysis. Oliver & Boyd Publishing Company.

4. Bond, G.C. 2004. Heterogeneous Catalysis. 5th Edition. Clarendon Press, Oxford.

10. CHEM-739 Ion Exchange Chemistry Cr. 03 (New Course) Introduction: Ion exchange reactions, matrix and functional groups, capacity, physical structure, properties of ion exchange resins. Ion exchange Equilibra: Swelling of ion exchange resins, ion exchange isotherms, exchange mechanism, Donnan potential. Ion Exchange kinetics: ion exchange processes, Ion exchange rate law, diffusion in porous media. Column Processes: breakthrough curves, sorption fronts, hydrodynamic effects. Applications of ion exchange: purification of gases, separation of metal ions, medical applications, catalysis by ion exchangers. Recommended Books 1. Dorfner, K. 1991. Ion Exchangers. Walter de Gruyter Berlin, New York. 2. Helfferich, F.G. 1995. Ion Exchange. Dover Edition. McGraw Hill, New York. 3. Harland, C.E. 1994. Ion Exchange: Theory and Practical. Springer Verlag, New York. 4. Rodri, A.E. 1986. Ion Exchange, Science and Technology. Martinus Nijhoff, Dordecht.

Semester-III & IV

Total Credit hour: 6 (Research/Thesis) The research scholars are supposed to carry out research on any specialized topic as assigned by the research supervisor throughout semester-III and IV. The comprehensive examination will held before the viva voce examination. It is essential to pass the comprehensive examination before appearing for the viva voce examination.

Course Detail for the Degree of M.Phil. / Ph.D. in Organic Chemistry Semester-I Total credit: 12


Credits

CHEM-740 Advanced Stereochemistry 3

CHEM-741

Advance NMR Spectroscopy 3

CHEM-742

Physical-Organic Chemistry 3

CHEM-743

Medicinal Chemistry 3

20 CHEM-744

Pericyclic Reactions 3

CHEM-745

Advance By Name Reactions 3

CHEM-746

Advanced Practicals in Organic Chemistry 3

Total Credits 12 A student may opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours

List of Courses for Semester-I 1. CHEM-740

Advanced Stereochemistry Stereochemistry of cyclic and fused systems; stereochemical outcome of addition, substitution, elimination, pericyclic reactions and molecular rearrangements; Felkin-Anh’s Principle; ee and de; stereoselectivity vs stereospecificity; asymmetric syntheses involving the use of chiral pool, chiral reagents and chiral catalysts. Recommended Books

1. Eliel, E.L. Wilen S.H and Mander, L.N. 1994. Stereochemistry of Organic Compounds. John Wiley & Sons, New York.

2. Morris, D.G. 2001. Stereochemistry. RSC (Cambridge), UK. 3. North, M. 1998. Principles and Applications of Stereochemistry. Stanley Thornes Publishers

Ltd (Cheltenham), UK. 4. Nasipuri, D. 2012. Stereochemistry of Organic Compounds: Principles and Applications.

New Age International Ltd, New Delhi.

2. CHEM-741

Advance NMR Spectroscopy A short review of 1D NMR including chemical shift, coupling constant, spin-spin splitting etc; 13C-NMR, broad band, dept-45o, 90o and 135o; nÖe; 2D NMR; merits and demerits of each 2D NMR technique that includes homonuclear (COSY, NOESY, inadequate) heteronuclear (HMQC, HMBC, HOHAHA, TOCSY, SECSY etc); joint application of 1D and 2D NMR with IR and UV for structure elucidation, stereochemistry and dynamic studies of intermediate sized molecules.

Recommended Books 1. Lambert, J.B and Rittner, R. 1987. Recent Advances in Organic NMR Spectroscopy. Norell

Press. 2. Croasmun, W.R and Carlson, R.M.K. 1994. 2D NMR Spectroscopy: Applications for

Chemists and Biochemists. 2nd Edition. John Wiley & Sons, Canada.

21 3. Simpson, J.H. 2012. Organic Structure Determination using 2D NMR Spectroscopy-A

Problem Based Approach. Academic Press, Oxford, UK.

3. CHEM-742 Physical-Organic Chemistry Chemical reactions and energy changes; qualitative aspects of collision; transition state theories,

rates and equilibria; tracer techniques, trapping of intermediated; interpretation of kinetic data; correlation of structure with reactivity; linear free energy relationship; stereochemical and stereoscopic evidences; study of reaction mechanism of some recent reactions. Recommended Books





4. CHEM-743 Medicinal Chemistry Introduction to medicinal chemistry, structure activity relationship (SAR); classification of

synthetic drugs; general properties, chemistry, biological action, SAR and therapeutic application of alkaloids (atropine, morphine, ephedrine etc.), anti-neoplastics (tamoxifen, mercaptopurine, vincristine etc), antibiotics (penicillins, cephalosporins, streptomycin, tetracyclins, chloramphenicol, erythromycin’ etc.) and NSAIDs. Recommended Books





5. CHEM-744 Pericyclic Reactions Frontier orbitals (HOMO-LUMO), symmetry conservation, and Huckle-Möbius approaches for

electrocyclization, cycloaddition, sigmatropic and chelotropic reactions; Claisen-Ireland reaarandement; stereochemical aspects and stereoselectivity / stereospecificity of above said reactions.

Recommended Books

22

1. Eliel, E.L. Wilen S.H and Mander, L.N. 1994. Stereochemistry of Organic Compounds. John Wiley & Sons, New York. 2. Morris, D.G. 2001. Stereochemistry. RSC (Cambridge), UK. 3. North, M. 1998. Principles and Applications of Stereochemistry. Stanley Thornes Publishers



6. CHEM-745 Advance By Name Reactions By name reactions of current research interest that have wide application in synthetic chemistry,

for example, Heck, Mitsunobu reactions, Stille, Suzuki coupling reactions, Sharpless asymmetric epoxidation and dihydroxylation etc.

7. CHEM-746 Advanced Practicals in Organic Chemistry Practicals related to organic chemistry enabling the students to use the UV-Visible spectroscopy,

FTR, TGA, Atomic absorption spectroscopy, HPLC, CHN analyzer, GC-Ms etc

Recommended Books 1. Eliel, E.L. Wilen S.H and Mander, L.N. 1994. Stereochemistry of Organic Compounds. John

Wiley & Sons, New York. 2. Morris, D.G. 2001. Stereochemistry. RSC (Cambridge), UK. 3. North, M. 1998. Principles and Applications of Stereochemistry. Stanley Thornes Publishers



Semester-II Total credit: 12


Credits

CHEM-750 Advance Organic Synthesis 3

CHEM-751

Mass Spectrometry 3

CHEM-752

Natural Product Chemistry 3

CHEM-753

Organometallic Chemistry 3

CHEM-754

Heterocyclic Chemistry 3

CHEM-755

Polymer Chemistry 3

Total Credits 12

23 A student can opt four courses of 12 credit hours offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours. List of Courses for Semester II *Courses will be offered depending on the availability and interests of the faculty. 1. CHEM-750

Advance Organic Synthesis Methods of C-C, C-N and C-O bond; asymmetric synthesis; synthesis of aromatic compounds;

functional group interconversion (FGI); Introduction to reterosynthesis and disconnection approach, one and two group C-X disconnections. Donar and acceptor synthesis and concepts of “Umpulung”. C-C disconnections and disfunctionalized compounds. Devising synthetic schemes for unknown molecules and some natural products.

Recommended Books 1. Kemp, W. 1975. Organic Spectroscopy. Macmillan, London. 2. Braun, R.D. 1987. Introduction to Instrumental Analysis. McGraw-Hill, New York. 3. Williams, D.H and Fleming, I. 1995. Spectroscopic Methods in Organic Chemistry.

McGraw-Hill Higher Education, New York. 4. Dyer, J.R. 1965. Applications of Absorption Spectroscopy to Organic Compounds. Prentice

Hall, London. 5. House, H.O. 1972. Modern Synthetic Reactions. Benjamin, California. 2. CHEM-751 Mass Spectrometry The mass spectrometer, ionization and ionic source, mass analyzers, metastsble ion, ion detection

and recording. Electron impact (EI) and chemical ionization (CI), field ionization (FI), field desorption (FD), fast atom bombardment (FAB +ve and FAB –ve), plasma desorption, thermospray, electrospray mass spectra, fragmentation pattern of common functional group. Structural elucidation using mass spectrometry in conjunction with other spectroscopic techniques.

Recommended Books

1. Kemp, W. 1975. Organic Spectroscopy. Macmillan, London. 2. Braun, R.D. 1987. Introduction to Instrumental Analysis. McGraw-Hill, New York. 3. Williams, D.H and Fleming, I. 1995. Spectroscopic Methods in Organic Chemistry.


Hall, London. 5. House, H.O. 1972. Modern Synthetic Reactions. Benjamin, California. 3. CHEM-752

Natural Product Chemistry Introduction to alkaloids, steroids, terpenes, flavonoids, coumarins and saponins; isolation, structure elucidation and biological activities of terpenes, vitamin D, estrogens, prostaglandins, bile acids, cholesterol, quinine, flavonoids etc.

24

Recommended Books 1. Kemp, W. 1975. Organic Spectroscopy. Macmillan, London. 2. Braun, R.D. 1987. Introduction to Instrumental Analysis. McGraw-Hill, New York. 3. Williams, D.H and Fleming, I. 1995. Spectroscopic Methods in Organic Chemistry.


Hall, London. 5. House, H.O. 1972. Modern Synthetic Reactions. Benjamin, California. 4. CHEM-753

Organometallic Chemistry Synthesis and applications of organoLi, organoMg, organoCu, organoZn, organoSn, organoPd and organoZr compounds with stereochemical outcomes; ylides that include organoS, organoP compounds; metathesis (both first and second generation Grub’s catalysts).

Recommended Books

1. Crabtree, R. H. 2005. The Organometallic Chemistry of Transition Metals. John Wiley & Sons, New York.

2. Astruc, D. 2007. Organometallic Chemistry and Catalysis. Springer-Verlag, Berlin (Heidelberg).

3. Spessard, G.O and Miessler, G.L. 1997. Organometallic Chemistry. Prentice Hall PTR. 4.

5. CHEM-754 Heterocyclic Chemistry Chemistry of heterocyclic compounds containing oxygen, nitrogen and sulphur with emphasis on

their synthesis, reaction, stereochemistry and spectroscopy; fused ring systems involving furan, pyrrole and thiophene, heterocyclic analogues of quinoline, heterocyclic compounds with more than one heteroatom, heterocyclic compounds with a seven membered ring. Recommended Books

1. Morrison, R.T and Boyd, R.N. 1967. Organic Chemistry. Allyn & Bacon, London. 2. Younas, M. 2007. Organic Spectroscopy. A. H. Publisher, Lahore. 3. Silverstein, R.M. Bassler, G.C and Morrill, T.C. 1991. Spectrometric Identification of

Organic Compounds. Wiley, New York. 6. CHEM-755 Polymer Chemistry Introduction to polymer chemistry; step-growth polymerization; free radical addition

polymerization; ionic polymerization; stereochemistry polymers; polymerization using Ziegler-Natta catalyst; stereo-regulation and conformation of polymers; molecular weight determination; structure-property relation; reactions of synthetic polymers; polymer degradation and stability with special emphasis on thermal and photo-degradation. Recommended Books

1. Finar, I.L. 1964. Organic Chemistry. Vol-II, Longmans Green & Co. London. 2. Smith, M.B and March, J. 2000. March's Advanced Organic Chemistry: Reactions,

Mechanisms, and Structure. 5th Edition. Wiley.

25 3. Streitwieser, A. Heathcock, C and Kosower, E.M. 1992. Introduction to Organic Chemistry.

Macmillan, New York. 4. Pine, S.H. 1980. Organic Chemistry. McGraw-Hill, New York. 5. Gould, E.S. 1959. Mechanism and Structure in Organic Chemistry. Holt, Rinehart &

Winston, New York. Semester-III & IV

Total Credit hour: 6 (Research/Thesis) The research scholars are supposed to carry out research on any specialized topic as assigned by the research supervisor throughout semester-III and IV. The comprehensive examination will held before the viva voce examination. It is essential to pass the comprehensive examination before appearing for the viva voce examination.

Curriculum for M.Phil/MS in Biochemistry Course Work: 24 Credit Hours

Semester Courses/Credits First 12 Second 12 Third and Fourth (Thesis) 06 Total Credits 30

● In addition to the course work and thesis, each student will have to give two seminars in

fourth semester. ● Each student will present a literature survey report in the beginning of third semester

related to his/her area of research.

26

● The course work will be completed in first and second semesters whereas research/ thesis will be completed in third and fourth semesters.

Courses being offered in 1st and 2nd Semester

1st Semester

Course Code Course Title Credits CHEM-760* Protein Structure, Function and Engineering 3(3+0) CHEM-764* Environmental Biochemistry and Toxicology 3(3+0) CHEM-765* Biochemical Basis of Endocrinology 3(3+0) CHEM-770* Clinical Biochemistry Laboratory Techniques 3(0+3)

2nd Semester

Course Code Course Title Credits CHEM-771* Recombinant DNA Technology 3(3+0) CHEM-774* Animal and Plant Tissue Culture 3(3+0) CHEM-775* Bioinformatics and Comparative Genomics 3(3+0) CHEM-780* Techniques for Studying Bio-molecules 3(3+0)

* Four courses have been chosen for each semester from subject list A and B mentioned at next page.

27

COURSE DESCRIPTION LIST A (Semester I) Course Code Course Title Credits CHEM-760 Protein Structure, Function and Engineering 3(3+0) CHEM-761 Enzyme Kinetics and Mechanisms 3(3+0) CHEM-762 Molecular Biochemistry 3(3+0) CHEM-763 Blood Chemistry and Immunochemistry 3(3+0) CHEM-764 Environmental Biochemistry and Toxicology 3(3+0) CHEM-765 Biochemical Basis of Endocrinology 3(3+0) CHEM-766 Neuro-Biochemistry 3(3+0) CHEM-767 Nutritional Biochemistry 3(3+0) CHEM-768 Biostatistics and Biomathematics 3(3+0) CHEM-769 Biochemistry Laboratory Skills 3(0+3) CHEM-770 Clinical Biochemistry Laboratory Techniques 3(0+3) Total Credits 12*

LIST B (Semester II)

Course Code Course Title Credits CHEM-771 Recombinant DNA Technology 3(3+0) CHEM-772 Drug Designing and Drug Metabolism 3(3+0) CHEM-773 Clinical Biochemistry 3(3+0) CHEM-774 Animal and Plant Tissue Culture 3(3+0) CHEM-775 Bioinformatics and Comparative Genomics 3(3+0) CHEM-776 Pathogens and Pathogenicity 3(3+0) CHEM-777 Genomics and Proteomics 3(3+0) CHEM-778 Cell Biology 3(3+0) CHEM-779 Current Topic in Biochemistry 3(3+0) CHEM-780 Techniques for Studying Bio-molecules 3(0+3) CHEM-781 Molecular Biology Lab Skills 3(0+3) Total Credits 12* *A student may opt four courses of 12 credit hours in on semester offered from the list depending upon the availability of the teacher. Each course will be of 3 credit hours

28

SEMESTER- I 1. CHEM-760 Protein Structure, Function and Engineering

Overview of Protein Structures; Secondary, Tertiary, and Quaternary structures, Classification of proteins according to their functions, Protein families on basis of structure; Secondary and Tertiary Structure prediction, X-ray crystallography and NMR spectroscopy of proteins, Molecular modeling and other techniques are used to solve structures and develop models of macromolecules; Genomes and Proteins; Protein folding pathways; Protein denaturation; Protein Engineering; Production of Recombinant Proteins; Post translational and Post transcriptional modifications; Chemical modification and site directed mutagenesis; Gene shuffling and chimeric enzymes; In vitro directed evolution of enzymes and other proteins. Recommended Books

1. Bujnicki, J. 2009. Prediction of Protein Structures, Functions, and Interactions. John Wiley & Sons, New York.

2. Creighton, T.E. 2005. Proteins: Structures and Molecular Properties. John Wiley & Sons, New York.

3. Whitford, D. 2005. Proteins: Structure and Function. John Wiley & Sons, New York. 4. Branden, C and Tooze, J. 1999. Introduction to Protein Structure. 2nd Edition. Garland

Science. 5. Voet, D. Voet J.G and Pratt, C.W. 1999. Fundamentals of Biochemistry. John Wiley & Sons,

New York. 6. Stryer, L. 2002. Biochemistry. 5th Edition. W.H. Freeman & Co. 7. Lesk, A.M. 2003. Introduction to protein Science. Oxford Publishers. 2. CHEM-761 Enzyme Kinetics and Mechanisms

Fundamentals of enzyme kinetics, Kinetics includes steady state, stopped-flow, single and multi-substrate kinetics; Derivation of rate equations; Applications of Michaelis-Menton equation; use of lineweaver-Burk plot and Eddie Hofstee plot for determination of Vmax and km; Free energy of activation and effects of enzymes; Mechanisms of enzyme catalyzed reactions; Allosteric control and regulation of enzymes; effects of pH, temperature and inhibitors; Kinetics of competitive, Non-Competitive and mixed inhibition; Kinetics of displacement reactions, ordered and random double displacement reactions. Recommended Books

1. Price, N and Stevens, L. 1999. Fundamentals of Enzymology: Cell and Molecular Biology of Catalytic Proteins. 3rd Edition. Oxford University Press.

2. Segel, I.H. 1993. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems. John Wiley & Sons.

3. Cornish-Bowden, A. 1995. Fundamentals of Enzyme Kinetics, 2nd Edition. Portland Press. 4. Eisenthal, R and Danson, M.J. 2002. Enzyme Assays: A Practical Approach (Practical

Approach Series). Oxford University Press. 5. Lehninger, A.L. Nelson, D.L and Cox M.M. 2000. Principles of Biochemistry, 3rd Edition.

Worth Publishers, New York.

29 6. Murray, R.K. Grammer, D.K. Mayes, P.A and Rodwell, V.W. 2000. Harper’s Biochemistry.

25th Edition. Appleton & Lange.

3. CHEM-762

Molecular Biochemistry Structural Organization of genes and Chromosomes in prokaryotes and eukaryotes; Nucleosome;

Properties of DNA and RNA, Replication of DNA, Replication theory of semi-conservative and conservative replication, Enzymes and proteins involved in replication; Molecular nature of mutations; DNA damage and repair, Synthesis and processing of RNA (Transcription), Reverse Transcription and Replication of viral genomes, Genetic code and wooble hypothesis; protein synthesis, Translational factors, Post transcriptional and post translational Modifications, Control of transcription and translation, Secretion and targeting of proteins, Genetic Diseases related to error in transcription and translation.

Recommended Books 1. McKee, T. McKee, J.R and Depra, P. 2008. Biochemistry: The Molecular Basis of Life

Student Study Guide / Solutions Manual. 4th Edition. Oxford University Press, USA. 2. Elliott, W.H and Elliott, D.C. 2009. Biochemistry and Molecular Biology. 4th Edition. Oxford

University Press, USA. 3. Lehninger, A.L. Nelson, D.L and Cox, M.M. 2000. Principles of Biochemistry. 3rd Edition.

Worth Publishers, New York. 4. Voet, D. Voet, J.G and Pratt, C.W. 1999. Fundamentals of Biochemistry. John Wiley &

Sons, New York. 5. Murray, R.K. Grammer, D.K. Mayes, P.A and Rodwell, V.W. 2000. Harper’s Biochemistry.

25th Edition. Appleton & Lange. 6. Wilson, K and Walker, J. 2005. Principles and Techniques of Biochemistry and Molecular

Biology. Blackwell Science, New York.

4. CHEM-763

Blood Chemistry and Immunochemistry Introduction to the principles and procedures of various tests performed in blood Chemistry,

Physiological basis, and clinical significance of test results, Basic biochemical laboratory techniques and safety, Analysis of electrolytes, acid-base balance, proteins, carbohydrates, lipids, enzymes, endocrine function, and toxicology, Introduction to different types of ELISA; Fundamentals of immune system; elements of innate and acquired immunity, immunogens and antigens, antibody structure and function; antigen-antibody interactions; genetic basis of antibody structure; monoclonal antibodies; biology of the B lymphocytes, role of MHC in the immune system; biology of the T lymphocyte; activation and function of T and B cells; control mechanisms in immune response, cytokines, complement, hypersensitivity reactions; type I, II, III, IV, autoimmunity; resistance and immunization to infectious diseases; applications of immunological functions.

Recommended Books

1. Kindt, T.J. Osborne, B.A. Goldsby, R.A and Kuby, J. 2006. Immunology. 6th Edition. W.H. Freeman & Co.

2. Paul, W.E. 2008. Fundamental Immunology. 6th Edition. Lippincott Williams & Wilkins. 3. Murphy, K.M. Travers, P and Walport, M. Immunobiology. 7th Edition. Garland Science.

30 4. Coico, R. 2009. Immunology: A Short Course. 6th Edition. Wiley-Blackwell. 5. Van, C.J. van-Reganmortel, M.H.V and Dekker, M. 1994. Immunochemistry. Marcel

Dekker, New York. 6. Sompayrac, L.M. 2008. How the Immune System Works. 3rd Edition. Wiley-Blackwell

Publishers, New York. 7. DeHaan, M.R. 1983. Chemistry of the Blood. Zondervan Publishers, Paris. 8. Tips, J. 2007. Blood Chemistry & Clinical Nutrition. Apple-a-Day Press, UK.

5. CHEM-764

Environmental Biochemistry and Toxicology Environment and Biochemistry, Toxic gases liberation and their effects on biochemical system,

Noise Pollution, Green House effects, Global Warming, Biological surface effects of water pollution, industrial waste water, sewage and other wastes, radioactive waste in water and their effects, soil and deeper earth pollution, effects of pesticides on life. Toxication versus detoxication; Bacterial Toxins, toxic responses to foreign compounds; Teratogenesis, Immunotoxicity, Genetic toxicity, Chemical carcinogenesis; Biochemical mechanisms of toxicity; specific examples, Tissue lesions: liver necrosis, Tissue lesions: kidney damage, lung damage, Neurotoxicity, Exaggerated and unwanted pharmacological effects, Physiological effects of multi-organ metals toxicity.

Recommended Books 1. Hathway, D.E. 2005. Molecular aspects of toxicology. Humana Press. 2. Pepper, I.L. 2006. Environmental and Pollution Science. 2nd Edition. McGraw-Hill, New

York. 3. Moon, T.W and Mommsen, T.P. 2005. Environmental Toxicology. Vol. 6. Elsevier Science. 4. William, H.S. 1997. Biogeochemistry: an analysis of Global Change. 2nd Edition. Acad. Press

California, USA. 5. Stantey, E.M. 1995. Environmental Chemistry. 4th Edition. Lewis Publishing Inc. Michigan.

6. CHEM-765

Biochemical Basis of Endocrinology General Principles of Endocrinology, Biochemical synthesis of hormones, Signal Transduction

and Other Membrane Phenomena, Signal Transduction pathways, cAMP mediated pathways, Disorders of calcium and phosphate homeostasis, Disorders of the hypothalamus and pituitary gland; Hyperthyroidism, Hypothyroidism, Goiter; thyroiditis; tumors of the thyroid gland, Diseases of the parathyroid glands, Diseases of the adrenal cortex, Cushing's syndrome, Adrenocortical insufficiency, Endocrine hypertension, Gonadal diseases (hypogonadism, gonadal dysgenesis, disorders of sexual determination and differentiation, Multiple endocrine neoplasia; polyglandular autoimmune syndrome, Osmoregulation and excretion, Biological rhythms, Type 1 and Type 2 diabetes mellitus,

Recommended Books 1. Guyton, A.C and Hall, J.E. 2000. Text Book of Medical Physiology. 10th Edition. W B

Saunders Company. 2. Bolander, F.F. 2004. Molecular Endocrinology. 3rd Edition. Academic Press. 3. Griffin, J.E and Ojeda, S.R. 2003. Textbook of Endocrine Physiology. 5th Edition. Oxford

University Press.

31 4. Jameson, J.L. Kasper, D.L. Fauci, A.S. Braunwald, E. Longo, D.L and Hauser, S.L. 2006.

Harrison's Endocrinology. McGraw Hill. 5. Gardner, D and Shoback, D. 2007. Greenspan's Basic & Clinical Endocrinology. 8th Edition.

McGraw Hill Medical. 6. CHEM –766

Neuro-Biochemistry Molecular structure and function of nerve tissue, intra - and inter-neuronal communication

mechanisms, control of gene expression and membrane biogenesis in neurons and ganglions, RNA and protein synthesis in the neuron, energy sources of the nerve cell, chemistry of electrogenic membranes, synaptic transmission, biochemistry of neuropeptides. Biochemical basis of learning, memory, and various brain dysfunctions. Organization of nervous system-CNS, ANS & PNS, meninges, Blood Brain Barrier, cerebrospinal fluid– composition, function and circulation, Neuron & its cell biology, glial cells, Biochemical composition of brain tissue. Carbohydrate, lipid metabolism of brain, transports of amino acids in brain, Synapse- Synaptogenesis, myelination, synaptic function, biochemistry of developing and aging brain, Neural signaling, channels pumps and transporters, Neurotransmitters, Neuromediators. Neurological Diseases/Disorders: molecular and biochemical basis of important neurological disease: traumas, stroke, multiple sclerosis, epilepsy, Alzheimer’s disease, Parkinson’s disease, and some behavioral and psychiatric disorders

Recommended Books 1. Hall, Z.W. 1992. An Introduction to Molecular Neurology. Sinauer Associates, UK. 2. Delcomyn, F. 1998. Foundations of Neurology. W.H. Freeman, USA. 3. Vizi, S.E and Lajtha, A. 2003. Handbook of Neurochemistry and Molecular Neurobiology:

Neurotransmitter Systems. Springer Science & Business Media. 4. Zigmond, M.J. Bloom, F.E. Landis, S.C. Roberts, J.L and Squire, L.R. 2003. Fundamental

Neuroscience: Academic Press, San Diego. 5. Chatterjee, C.C. 2002. Human Physiology. Humana Press.

7. CHEM- 767

Nutritional Biochemistry Transport of nutrients, study of active and passive transport mechanisms, the glucose transporter

as unique family of proteins, the role of specialized heavy metal ATPases as transporter, energy requirements, BMR, SDA, RQ, quantitative problems, the effect of physical activity on energy consumption. N-balance, estimation of protein quality, protein score, assessment of protein status, protein calorie, malnutrition states, deficiency of amino acids and their effects on the developing offspring, specificity of amino acids in several physiological processes e.g., suppression of pain., stimulation of appetite, the role of metals and non-metals in nutritional biochemistry, with emphasis on the interaction with enzymes, proteins and nucleic acids, nutraceuticals, food toxins.

Analysis of food including genomic analysis for GM food, The dietary influence of food and the influence of genes on diet-nutrigenomics and nutrigenetics, Nutraceuticals and their appraisal in terms of gene expression and metabolite formation

Recommended Books 1. Stryer, L. 2002. Biochemistry. 5th Edition. W.H. Freeman & Co.

32 2. Lori, A. Smolin, L.A and Grosvenor, M.B. 2000. Nutrition: Science and Applications. 3rd

Edition. Saunders College Publishing. 3. Garrow, J.S and James, W.P.T. 2003. Human Nutrition and Dietetics. 9th Edition. Churchill

Livingstone. 4. Murray, R.K. Grammer, D.K. Mayes, P.A and Rodwell, V.W. 2000. Harper’s Biochemistry.

25th Edition. Appleton & Lange.

8. CHEM- 768

Biostatistics and Biomathematics Organizing and summarizing data, biostatistics, population samples, bio-statistical analysis,

ordered array, frequency distributions, polygons and curves, histograms; measures of central tendency, arithmetic mean; measures of dispersion, range, mean deviation, standard deviation and error, coefficient of variation; probability distributions, normal, binomial and poisson distributions; hypothesis testing, statistical decision, one and two-sample hypothesis, Z-and other tests; simple linear regression and correlation; analysis of variance; nonparametric and distribution free test. Biomathematics, algebraic expressions, polynomials, factoring of polynomials, fractional expressions; the binomial theorem and its use; use of differentiation and integration highs and lows, a special kind of point, optimization, functions in reality, the exponential growth curve, the definite integral, properties and applications of definite integration.

Recommended Books 1. Rosner, B. 2005. Fundamentals of Biostatistics. 6th Edition. Duxbury Press. 2. Robeva, R.S. Kirkwood, J.R. Davies, R.L. Farhy, L. Kovatchev, B.P. Straume, M. and

Johnson, M.L. 2007. An Invitation to Biomathematics. 1st Edition. Academic Press. 3. Zar, J.H. 2010. Biostatistical Analysis. 5th Edition. Pearson. 4. Glantz, S.A. 1989. Primer of Biostatistics. 2nd Edition. McGraw Hill.

9. CHEM- 769

Biochemistry Laboratory Skills Quantitative tests for amino acids, proteins, carbohydrates and lipids, Estimation of proteins and

carbohydrates using different methods. Estimation of glucose by glucose oxidase method. Chromatographic separation of sugars. Determination of chain length of polysaccharide. Fractionation of lipids. TLC separation of polar and non-polar lipids. isolation and assays of enzymes to demonstrate the effect of various physical and chemical factors on enzyme activity employing enzymes like alkaline phosphatase and lactate dehydrogenase. Study of enzyme inhibition and enzyme kinetics. Dialysis, ultrafiltration and preservation of proteins by lyophilization. Estimation of vitamins A, B1, B2 and others in foods. Estimation of mineral constituents of foods by atomic absorption spectrophotometer. Determination of fatty acids by gas chromatography. Analysis of amino acids, sugars, and other constituents by HPLC.

Recommended Books

1. Boyer, R.F. 1993. Modern Experimental Biochemistry. 2nd Edition. Benjamin-Cummings Publishing.

2. Walker, J.M. 1994. The Basic Protein and Peptide Protocols. Humana Press.

33 3. Alexander, R.R and Griffiths, J.M. 1993. Basic Biochemical Methods. 2nd Edition.

Wiley-Liss. 4. Varley, R. 1988. Varley’s Practical Clinical Biochemistry. 6th Edition, CBS Publishers and

Distributors. 5. Ausubel, F.M. 1999. Short Protocols in Molecular Biology. 4th Edition. John Wiley & Sons.

10. CHEM- 770

Clinical Biochemistry Laboratory Techniques Blood sampling Techniques, Microscopy, Complete blood count, Preparation of blood smear,

staining, differential leukocytes count, count of neutrophil eosinophil, monocytes, and lymphocytes. Liver function tests; SGOT, SGPT, ALP, LDH, CPK. bleeding and clotting time, Renal test Profile Urea, Uric Acid, Cretinine, Lipid Profiles; LDL, VDL, Cholesterol; Cardiac Enzymes test, CKMB, kidney Function tests, A/G ratio, serum Na, K, Ca and HClO3, Urine Analysis, bile pigments, bilirubin, urobilinogen, urobilin, albumin, urea, ketones bodies, reducing sugars, urate crystals. Pregnancy and fertility tests, Blood groups, Sero diagnosis of infectious diseases, Tests for malaria and typhoid. Assay of the various hormones including thyroid, growth, adrenal and others by radioimmunoassay (RIA). Enzyme-linked immunosorbent assay (ELISA) methods for the assay of biological compounds. Use of PCR in diagnosis and paternity tests, DNA Sequencing and Disease biomarkers especially different types of cancer and heart diseases. Cultivation of microorganisms in laboratory using solid and liquid culture media; test tube, petri plate and shake flask cultures; isolation of pure culture; study of physical characteristics of microorganisms; bacterial growth curve; preservation of microbial strains.

Recommended Books 1. Joklik, W.K. Willert, H.P. Amos, B.D and Wilfert, C.M. 1996. Zinsser’s Microbiology, 20th

Edition. Appelton and Lange. 2. Cappuccino, J.G and Sherman, N. 1996. Microbiology: A Laboratory Manual. 4th Edition.

Benjamin/Cummings Publishing Co. Inc. New York. 3. Fleisher, T.A. Schwartaz, B.D. Shearer, W.T and Strober, W. 1995. Clinical Immunology:

Principles and Practice, Mosby, London. 4. Boyer, R.F. 1993. Modern Experimental Biochemistry. 2nd Edition. Benjamin-Cummings

Publishing. 5. Walker, J.M. 1994. The Basic Protein and Peptide Protocols. Humana Press. 6. Gerhardt, P.(Ed.) 1981. Manual of Methods for General Bacteriology, American Society for

Microbiology. 7. Ausubel, F.M. 1999. Short Protocols in Molecular Biology. 4th Edition. John Wiley & Sons.

SEMESTER-II

34 1. CHEM-771 Recombinant DNA and Related Techniques DNA cloning methods; cloning vectors including plasmids, bacteriophages, cosmids, YAC

vectors, shuttle and expression vectors; gene splicing, genomic libraries, screening methods for gene libraries; DNA cloning restriction enzymes; DNA ligase; tumor inducing (Ti) plasmids; Southern and Northern blotting; chromosome walking; PCR; site specific mutagenesis; production of proteins. Potentials of recombinant DNA technology; gene therapies; restriction fragment length polymorphisms and disease detection (e.g. cystic fibrosis); human genome project; somatic cell cloning, stem cell research, other future prospects; social and commercial considerations.

Recommended Books 1. Brown, T.A. 2006. Gene Cloning and DNA Manipulation- An Introduction. 5th Edition.

Blackwell Publishing Inc., USA. 2. Primrose, S.B. Twyman, R.M and Old, R.W. 2006. Principles of Gene Manipulation. 6th

Edition. Wiley-Blackwell. 3. Tanley, W.M.S and Rapley, N.J. 2005. Molecular Bio-methods Handbook. Humana Press

Inc, Totowa. 4. Smith, A. 1995. Gene Expression in Recombinant Microorganisms. Marcel Dekker, New

York. 5. Krawezak, M and Schmidtke J. 1994. DNA fingerprinting. Bioscientific, Oxford. 6. Lehninger, A.L. Nelson, D.L and Cox, M.M. 2000. Principles of Biochemistry. 3rd Edition.

Worth Publishers, New York. 7. Alberts, B. Bray, D. Lewis, J. Raff, M. Roberts, K and Watson, J.D. 1994. Molecular

Biology of the Cell. 3rd Edition. Garland Publishers. 2. CHEM-772 Drug Designing and Metabolism

Introduction to Drugs, Drug Discovery Techniques, Molecular Basis in Drug Design, Strategies and Principles in Rational Drug Design, Drug Development, Case Studies in Topics in Drug Discovery, Design and development. Use of recombinant DNA technology: study of virulence factors of pathogenic agents and rational drug design. Molecular diagnostics; fundamental concepts and their application to human infectious agents. CoMFA, CoMSIA and QSAR. Chemistry and mechanism of action of antibacterial, antiviral, antiprotozoal, antifungal and antihelminthic agents; chemistry and mechanism of action of xenobiotics, mechanisms of drug resistance; biochemical transformation of drugs

Recommended Books 1. Schaechter, M. Medoff, G and Einsenstein, B.L. 1993. Mechanisms of Microbial Disease. 2nd

Edition. Williams & Wilkins, Maryland. 2. Parket, M.T and Collier, L.H. 1990. Principles of Bacteriology, Virology and Immunity. 8th

Edition. Edward Arnold Publications, London. 3. Marks, D.B. Marks, A.D and Smith, C.M. 1996. Basic Medical Biochemistry. A Clinical

Approach, William & Wilkins. 4. Marshall, W.J and Bangest, S.K. 1995. Clinical Biochemistry; Metabolic and Clinical

Aspects. Churchill Livingstone.

35

3. CHEM-773

Clinical Biochemistry General composition of blood, mechanisms of blood clotting, blood lipoproteins, blood enzymes,

metabolites in clinical diagnosis, Nature and functions of hormones, hormonal and other regulatory mechanisms. Radioimmunoassay, Body defense mechanisms; the immune system; antibody structure, monoclonal and polyclonal antibodies; blood groups, practical applications.. Introduction to molecular

edition. · as η 2 to η 7 systems. synthesis, properties and nature of bonding in pi complexes....

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