chromosome—a string like, gene- containing molecule in the nucleus of a cell gene—the...
TRANSCRIPT
![Page 1: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/1.jpg)
Genes and Genomes Chromosome—A string like, gene-
containing molecule in the nucleus of a cell
Gene—The fundamental unit of biological inheritance
Genome—An organism’s entire complement of DNA
![Page 2: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/2.jpg)
Gene Therapy The manipulation of someone’s genetic
material to prevent or treat disease
An attempt to alter the workings of cells by:• replacing a missing or defective gene with a
normal one • repairing a faulty gene so it will function
properly• activating or deactivating a gene (switching it
on or off)
![Page 3: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/3.jpg)
Two Types of Gene Therapy Somatic cell therapy involves altering genes in
a person’s somatic (body) cells, such as liver or muscle cells, to treat an existing disorder. The alterations can help the person suffering from the disease but are not inheritable—they cannot be passed on to the person’s offspring.
Germ-line cell therapy entails modifying genes in germ-line cells (egg and sperm cells) and zygotes—and these alterations are inheritable.
![Page 4: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/4.jpg)
Gene Therapy Somatic cell therapy—The prevailing
view: if steps are taken to minimize harm, and if the potential benefits are substantial, somatic cell therapy is morally permissible.
Germ-line cell therapy—Safety concerns are so worrisome that, at least in its current immature stage, it is generally thought to be morally unacceptable.
![Page 5: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/5.jpg)
Moral Issues in Gene Therapy
Medical risks and benefits of the therapy
Duties to use the procedures to prevent suffering
Reproductive freedom The morality of practicing positive
genetics
![Page 6: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/6.jpg)
Reproductive Cloning Cloning is the asexual production of a
genetically identical entity from an existing one.
Reproductive cloning is the creation of a genetic duplicate of an adult animal or human; aimed at the live birth of an individual.
Therapeutic, or research, cloning is cloning for purposes other than producing a live individual.
![Page 7: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/7.jpg)
Human Reproductive Cloning Arguments for Cloning:
• Appeal to reproductive liberty• Benefits to infertile couples
Arguments Against Cloning:• Cloning is unnatural.• It violates the right of the resulting clone to
a unique identity or future. • It will result in the demeaning artificial
manufacture of children as products.
![Page 8: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/8.jpg)
The Beneficence Argument for Genetic Enhancement
There is no morally significant distinction between genetic repair and enhancement.
If we have the power to make someone’s life better through genetic enhancement, we should do it.
![Page 9: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/9.jpg)
The Open-Future Argument Against Cloning
Søren Holm: What is wrong with living your life as a
clone in the shadow of the life of the original? It diminishes the clone’s possibility of living a life that is in a full sense of that word his or her life. The clone is forced to [try] to perform a complicated partial re-enactment of the life of somebody else (the original).
![Page 10: Chromosome—A string like, gene- containing molecule in the nucleus of a cell Gene—The fundamental unit of biological inheritance Genome—An organism’s](https://reader036.vdocuments.net/reader036/viewer/2022082816/56649d895503460f94a6f31b/html5/thumbnails/10.jpg)
The Open-Future Argument Against Cloning
National Bioethics Advisory Commission: [A]ll of these concerns are not only quite
speculative, but are directly related to certain specific cultural values. Someone created through [cloning] may or may not believe that their future is relatively constrained. Indeed, they may believe the opposite. In addition, quite normal parenting usually involves many constraints on a child’s behavior that children may resent.