© cognis corporation 2001 now it never hurts to look a little younger. ™
TRANSCRIPT
© Cognis Corporation 2001
Now it never hurts to look a little younger.™
© Cognis Corporation 2001
• fatty acids• fatty alcohols• glycerine• bulk surfactants• ...
• natural-source vitamin E• specialty surfactants• emollients & emulsifiers• actives• ...
• coatings & inks• textile chemicals• lubricants• agricultural specialties• ...
© Cognis Corporation 2001
Actives from Care Chemicals
Advanced Delivery Systems
Next-generation AHA Technology
Innovative Actives
Hydagen® ChitosanGenerol® Phytosterols
© Cognis Corporation 2001
NeoStrata Company, Inc.
Dr. Van Scott and Dr. Yu
Drs. Van Scott and Yu published first paper on skin benefits of AHAs in 1974.
Inventors of amphoteric hydroxy complexes for low-irritation AHA actives.
NeoStrata holds over 100 patents on AHA technology.
Strategic Alliance with Cognis announced in 1999.
NeoStrata’s headquartersin Princeton, NJ.
© Cognis Corporation 2001
Known Benefits of AHAs
• Exfoliation
• Moisturization
• Reduction of fine lines and wrinkles
• Collagen synthesis
• Firming
• Skin whitening
Downside: stinging, irritation, ...
© Cognis Corporation 2001
the benefits of AHAs with
significantly reduced sting and irritation.
© Cognis Corporation 2001
Amphoteric Hydroxy Complex
© Cognis Corporation 2001
0 2 4 6 8 10 12 14 160.0
0.5
1.0
1.5
2.0
2.5
AHC
AHA
Irritation Threshold
C
on
cen
tra
tion
Time (arb. units)
Model of Controlled Release Concept
© Cognis Corporation 2001
Dansyl Chloride Cell Turnover Study(10% lactic acid solution vs 14.7% AHCare™ L 65 solution)*
* the lactic acid concentration is identical in these two solutions
34% increasein cell renewal
rate
pH = 2.4
© Cognis Corporation 2001
Results for Facial Sting Study AHC (high arginine) vs.
20% Lactic/NH4OH, neutralized to pH 3.5
0 2 3 5 7 80.0
0.2
0.4
0.6
0.8
AHA (Lactic) AHC (Lactic:Arginine mole ratio = 2.5:1)
Mea
n S
ting
Sco
re
Time (min)
© Cognis Corporation 2001
Results for Facial Sting Study AHC (low arginine) vs.
10% Lactic/NH4OH, neutralized to pH 2.2
0 2 4 6 80.0
0.5
1.0
1.5
AHA (Lactic) AHC (Lactic:Arginine mole ratio = 20:1)
Mea
n S
ting
Sco
re
Time (min)
© Cognis Corporation 2001
Results for Facial Sting Study AHC (high arginine) vs.
10% Glycolic/NH4OH, neutralized to pH 3.1
0 2 4 6 80.0
0.5
1.0
1.5
AHA (Glycolic) AHC (Glycolic:Arginine mole ratio = 2.5:1)
Mea
n S
ting
Sco
re
Time (min)
© Cognis Corporation 2001
Results for Facial Sting Study AHC (low arginine) vs.
10% Glycolic/NH4OH, neutralized to pH 2.3
0 2 4 6 80.0
0.5
1.0
1.5
2.0
AHA (Glycolic) AHC (Glycolic:Arginine mole matio = 15:1)
Mea
n S
ting
Sco
re
Time (min)
© Cognis Corporation 2001
Cumulative Irritation Study 20% Glycolic Acid Solutions, pH 3.5
0 2 4 6 8 10 12 14 160.0
0.5
1.0
1.5
2.0
2.5
3.0
AHA (Glycolic) AHC (Glycolic/Arginine mole ratio = 2.8:1)
Me
an Ir
rita
tion
Sco
re
Day
© Cognis Corporation 2001
Cognis has exclusively licensed these patents to commercialize AHCare™ technology based on glycolic and/or lactic acid.
AHCare™ is Patented Technology
Key patents:
• R. J. Yu and E. J. Van Scott, “Amphoteric composition and polymeric forms of alpha hydroxy acids and their therapeutic use,” US Patent 5,091,171 (1992).
• R. J. Yu and E. J. Van Scott, “Molecular complex and control-release of hydroxy acids,” US Patent 5,681,853 (1997).
• plus 10 others, issued or pending.
© Cognis Corporation 2001
AHCare™ Products
Two standard products:
• AHCare™ G 60: patented complex of glycolic acid and L-arginine, 74% total actives, glycolic/arginine mole ratio = 15:1
• AHCare™ L 65: patented complex of lactic acid and L-arginine, 75% total actives, lactic/arginine mole ratio = 20:1
© Cognis Corporation 2001
Value Proposition for Skin Care Customers
When you buy AHCare™ skin care ingredients from Care Chemicals you get:
• high efficacy with significantly reduced stinging and irritation
• freedom to practice under NeoStrata patents referenced above on a worldwide basis.
• formulation support - including frame formula development to match a market target
• claims substantiation support - including assistance with test methods for both in vitro and in vivo methods.
© Cognis Corporation 2001
Dansyl Chloride Cell Turnover StudyAnti-aging Cream containing 10% AHCare™ G 60
21% increasein cell renewal
rate
© Cognis Corporation 2001
Summary
• High efficacy
• Significantly reduced stinging and irritation
• Freedom to practice under NeoStrata patents
• Extensive support