- dna. simulation of interactions of radiation with biological systems at the cellular and dna level...
TRANSCRIPT
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- DNA- DNA
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Simulation of Interactions of Radiation with Biological Systems at the Cellular and DNA Level
Based on
Sponsored by Activity of
S. Agostinelli, S. Chauvie, N. Crompton, R. Corvó, F. Foppiano, S. Garelli, M. Krengli, F. Marchetto, P. Nieminen, M.G. Pia, V. Rolando, A. Solano, G. Sanguineti
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The concept of “dose” fails at cellular and DNA scales It is desirable to gain an understanding to the processes at all
levels (macroscopic vs. microscopic+cybernetic) Quantitative knowledge and strict user requirements
scientifically satisfying; may be used as feedback to experimentalists
Potential later connection to other than radiation-induced effects at the cellular and DNA level
Relevance for space: astronaut and airline pilot radiation hazards, biological experiments. Applications in radiotherapy, radiobiology, ...
Relevance
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Solar flare electrons,protons, and heavy ions
Jovianelectrons
Solar flare neutronsand -rays
SolarX-rays
Galactic and extra-galacticcosmic rays
Induced emission
(Neutrinos)
Trapped particles
Anomalouscosmic rays
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The South Atlantic Anomaly
(SAA)
Cou
rtes
y H
. Eva
ns (
ESA
)
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Relevance for space: astronaut and aircrew radiation hazards
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Programme description
-based “sister” activity to the Geant4 Low-E e.m. Working Group. Follows rigorous software standards
ESA-sponsored + INFN official activity Simulation of nano-scale effects of radiation at the DNA level Multiple approaches (RBE parameterisation, detailed biochemical
processes, etc.) can be implemented with Geant4 First year frame: Collection of user requirements & first prototypes First Milestone: Wide study of the problem area (completed) Various scientific domains involved: medical, biology, genetics,
software engineering, high and low energy physics, space physics
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-DNA Collaboration
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Physicalprocesses
Biologicalprocesses
Chemicalprocesses
Process userrequirements
Cou
rtes
y N
atur
e
Known, available
Unknown, not available
E.g. generation of free radicals in the cell
User requirements on geometry and visualisation
Collection of User Requirements
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Pro
toty
ping
5.3
MeV
alp
ha p
arti
cle
in a
cyl
indr
ical
volu
me
insi
de c
ell n
ucle
us. T
he in
ner
cyli
nder
has
a r
adiu
s of
50
nm.
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Cou
rtes
y A
. Bra
hme
(KI)
Courtesy A. Brahme (KI)
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Completion of Milestone II (rigorous collection of user requirements) to be completed by March 2001
Completion of the current 1-year programme by June 2001 Follow-on activity: code implementation based on user
requirements and improved prototypes Structure of the follow-on activity being outlined
Future
http://www.ge.infn.it/geant4/dna/