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Vendredi 8 mars 2019 12h-13h30 Hôpital du Saint-Sacrement, salle L0-19 sanofi-aventis « Genome wide meta-analysis of parent-of- origin effects of asthma, atopy and airway hyperresponsiveness in four cohorts » Aida Eslami, Ph.D. Postdoctoral Research Fellow Dr. Denise Daley's research group Centre for Heart and Lung innovation Providence Heart + Lung Institute St. Paul's Hospital, Burrard Building Vancouver, BC Invitée par le comité de recrutement de l’axe Santé des populations et pratiques optimales en santé IRIS 1645359 Objectifs d'apprentissage : - Genomic imprinting (parent-of-origin effects) Résumé de la conférence : Asthma is a complex disease caused by a combination of genetic and environmental factors. The main genetic effects of the common Single Nucleotide Polymorphisms (SNPs) identified by Genome-Wide Association Studies (GWAS) do not fully explain the heritability of asthma. Genomic imprinting (parent-of-origin effects) is a potential mechanism which may explain this missing heritability. We aimed to identify candidate genomic regions for imprinting in asthma, atopy and airway hyperresponsiveness.

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Vendredi 8 mars 2019

12h-13h30

Hôpital du Saint-Sacrement, salle L0-19 sanofi-aven tis

« Genome wide meta-analysis of parent-of-origin effects of asthma, atopy and airway

hyperresponsiveness in four cohorts »

Aida Eslami, Ph.D. Postdoctoral Research Fellow Dr. Denise Daley's research group Centre for Heart and Lung innovation Providence Heart + Lung Institute St. Paul's Hospital, Burrard Building Vancouver, BC

Invitée par le comité de recrutement de l’axe Santé des populations et pratiques optimales en santé

IRIS 1645359

Objectifs d'apprentissage :

- Genomic imprinting (parent-of-origin effects)

Résumé de la conférence :

Asthma is a complex disease caused by a combination of genetic and environmental factors. The main genetic effects of the common Single Nucleotide Polymorphisms (SNPs) identified by Genome-Wide Association Studies (GWAS) do not fully explain the heritability of asthma. Genomic imprinting (parent-of-origin effects) is a potential mechanism which may explain this missing heritability. We aimed to identify candidate genomic regions for imprinting in asthma, atopy and airway hyperresponsiveness.

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