Introduction

Hemochromatosis Alzheimer's Constant company A global, evolutionary Macarena It’s not only good for X-Men DNA is history

o Somewhere in your genetic code is the tale of every plague, every predator, every parasite, and every planetary upheaval your ancestors mangled to survive

Chapter 1

Hemochromatosis is inherited—and the gene for it is very common in certain populations

Iron Locking- Vivkings- founder’s effect Bubonic plague: 1/3 to ½= 25 million people People with Hemochromatosis are less

susceptible? Increase in European populations every time the

disease resurfaced over the ensuing three hundred years

Evolutionary bottleneck We did ask for it! Cystic fibrosis and TB

Chapter 3

Sunlight: Vitamin D and Folic Acid Skin Color

o Dark to protect folateo Light to manufacture vitamin Do Inuit

High cholesterol to increase vitamin D ACHOO Alcohol flush response (alcohol vs. tea) Slave trade and salt- evolutionary bottleneck Environmentally dependent What happens when the environment changes

(moves or migrations?)

Chapter 4

The fava bean- Where’s there folklore smoke, there’s medical fire

Free radicals and enzyme deficiency Fava cultivation and favism

o >400 million Fruit, botanical birth control & poison JBS Haldane

o SCDo Favismo Malaria

Why cultivate what can kill you?