年月日更新英文論文原著、総説、症例 -...

2018年 3月 23日更新

英文論文 - 原著、総説、症例 -

1. Yajima A, Toki T, Morinaga S, Sasano H, Sasano N. A retroperitoneal endocrine carcinoma. Cancer.

54:2040-2042. 1984 （症例）

2. Sasano H, Watanabe N, Sasano N. Corticosteroid binding in human artery. Tohoku Journal of Experimental

Medicine. 150(2):117-125. 1986 （原著）

3. Sasano H, Masuda T, Ojima M, Fukuchi S, Sasano N. Congenital 17 alpha-hydroxylase deficiency: a

clinicopathologic study. Human Pathology. 18(10):1002-1007. 1987 （原著）

4. Sasano H, Geelhoed GW, Silverberg SG. Intraoperative cytologic evaluation of lipid in the diagnosis of

parathyroid adenoma. American Journal of Surgical Pathology. 12(4):282-286. 1988 （原著）

5. Sasano H, White PC, New MI, Sasano N. Immunohistochemistry of cytochrome P-450 21-hydroxylase:

microscopic examination of the enzyme in the bovine adrenal cortex and kidney. Endocrinology.

122(1):291-295. 1988 （原著）

6. Sasano H, Ohkubo T, Sasano N, Immunohistochemical demonstration of steroid C-21 hydroxylase in normal

and neoplastic salivary glands. Cancer. 61(4):750-753. 1988 （原著）

7. Sasano H, White PC, New MI, Sasano N. Immunohistochemical localization of cytochrome P-450C21 in

human adrenal cortex and its relation to endocrine function. Human Pathology. 19(2):181-185. 1988 （原著）

8. Sasano H, Sasano N. Extraadrenal immunohistochemical distribution of steroid 21-hydroxylase in human.

Tohoku Journal of Experimental Medicine. 154(1):21-28. 1988 （原著）

9. Sasano H, Sasano N. Immunohistochemical demonstration of steroid C21 hydroxylase in normal and

neoplastic human breasts. Cancer. 62(6):1183-1187. 1988 （原著）

10. Sasano H, Okamoto M, Sasano N. Immunohistochemical study of cytochrome P-450 11 beta-hydroxylase in

human adrenal cortex with mineralo- and glucocorticoid excess. Virchows Arch A Pathol Anat Histopathol.

413(4):313-318. 1988 （原著）

11. Sasano H, Nose M, Sasano N. Lectin histochemistry in adrenocortical hyperplasia and neoplasms with

emphasis on carcinoma. Archives of Pathology & Laboratory Medicine. 113(1):68-72. 1989 （原著）

12. Sasano H, Mason JI, Sasano N. Immunohistochemical study of cytochrome P-45017 alpha in human

adrenocortical disorders. Human Pathology. 20(2):113-117. 1989 （原著）

13. Sasano H, Rojas M, Silverberg SG. Analysis of lectin binding in benign and malignant thyroid nodules.

Archives of Pathology & Laboratory Medicine. 113(2):186-189. 1989 （原著）

14. Sasano H, Sasano N, Okamoto M. Immunohistochemical demonstration of cholesterol side-chain cleavage

cytochrome P-450 in bovine and human adrenals. Pathology Research & Practice. 184(3):337-342. 1989 （原

著）

15. Sasano H, Sasano N, Okamoto M, Nonaka Y. Immunohistochemical demonstration of adrenodoxin

reductase in bovine and human adrenals. Pathology Research & Practice. 184(5):473-479. 1989 （原著）

16. Sasano H, Virmani R, Patterson RH, Robinowitz M, Guccion JG. Eosinophilic products lead to myocardial

damage. Human Pathology. 20(9):850-857. 1989 （原著）

17. Sasano H, Sasano N. What's new in the localization of sex steroids in the human ovary and its tumors?

Pathology Research & Practice. 185(6):942-948. 1989 （総説）

18. Sasano H, Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG.

Immunolocalization of aromatase, 17 alpha-hydroxylase and side-chain-cleavage cytochromes P-450 in the

human ovary. Journal of Reproduction & Fertility. 85(1):163-169. 1989 （原著）

19. Sasano H, Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG.

Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol

side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. Human Pathology.

20(5):452-457. 1989 （原著）

20. Sasano H, Mason JI, Sasano N. Immunohistochemical analysis of cytochrome P-450 17 alpha-hydroxylase

in pig adrenal cortex, testis and ovary. Molecular & Cellular Endocrinology. 62(2):197-202. 1989 （原著）

21. Sasano H, Wargotz ES, Silverberg SG, Mason JI, Simpson ER. Brenner tumor of the ovary: immunoanalysis

of steroidogenic enzymes in 23 cases. Human Pathology. 20(11):1103-1107. 1989 （原著）

22. Sasano H, Fukunaga M, Rojas M, Silverberg SG. Hyperthecosis of the ovary. Clinicopathologic study of 19

cases with immunohistochemical analysis of steroidogenic enzymes. International Journal of Gynecological

Pathology. 8(4):311-320. 1989 （原著）

23. Sasano H, Mori T, Sasano N, Nagura H, Mason JI. Immunolocalization of 3 beta-hydroxysteroid

dehydrogenase in human ovary. Journal of Reproduction & Fertility. 89(2):743-751. 1990 （原著）

24. Sasano H, Comerford J, Silverberg SG, Garrett CT. An analysis of abnormalities of the retinoblastoma gene

in human ovarian and endometrial carcinoma. Cancer. 66(10):2150-2154. 1990 （原著）

25. Sasano H, Saito Y, Sato I, Sasano N, Nagura H. Nucleolar organizer regions in human adrenocortical

disorders. Modern Pathology. 3(5):591-595. 1990 （原著）

26. Sasano H, Garrett CT, Wilkinson DS, Silverberg S, Comerford J, Hyde J. Protooncogene amplification and

tumor ploidy in human ovarian neoplasms. Human Pathology. 21(4):382-391. 1990 （原著）

27. Sasano H, Comerford J, Wilkinson DS, Schwartz A, Garrett CT. Serous papillary adenocarcinoma of the

endometrium. Analysis of proto-oncogene amplification, flow cytometry, estrogen and progesterone receptors,

and immunohistochemistry. Cancer. 65(7):1545-1551. 1990 （原著）

28. Kudo R, Sasano H, Koizumi M, Orenstein JM, Silverberg SG. Immunohistochemical comparison of new

monoclonal antibody 1C5 and carcinoembryonic antigen in the differential diagnosis of adenocarcinoma of the

uterine cervix. International Journal of Gynecological Pathology. 9(4):325-336. 1990（原著）

29. Sasano H, Mason JI, Sasaki E, Yajima A, Kimura N, Namiki T, Sasano N, Nagura H. Immunohistochemical

study of 3 beta-hydroxysteroid dehydrogenase in sex cord-stromal tumors of the ovary. International Journal of

Gynecological Pathology. 9(4):352-362. 1990 （原著）

30. Sasano H, Mason JI, Sasano N, Nagura H. Immunolocalization of 3b-hydroxylase dehydrogenase

(3b-HSD) in human adrenal cortex and its disorders. Endocrine Pathology. 92(1):94-101. 1990 （原著）

31. Imai T, Seo H, Murata Y, Funahashi H, Satoh Y, Sasano H, Matsui N, Takagi H.

Dexamethasone-nonsuppressible cortisol in two cases with aldosterone-producing adenoma. Journal of Clinical

Endocrinology & Metabolism. 72(3):575-581. 1991 （原著）

32. Sato S, Ito K, Ozawa N, Yajima A, Sasano H. Analysis of point mutations at codon 12 of K-ras in human

endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction.


33. Sasano H, Saito Y, Nagura H, Kudo R, Rojas M, Silverberg SG. Lectin histochemistry in mucinous and

serous ovarian neoplasms. International Journal of Gynecological Pathology. 10(3):252-259. 1991 （原著）

34. Fukushima K, Sasano H, Nagura H, Sasaki I, Matsuno S, Krozowski ZS. Immunohistochemical localization

of mineralocorticoid receptor in human gut. Tohoku Journal of Experimental Medicine. 165(2):155-163. 1991

（原著）

35. Sato S, Ito K, Ozawa N, Yajima A, Sasano H. Expression of c-myc, epidermal growth factor receptor and

c-erbB-2 in human endometrial carcinoma and cervical adenocarcinoma. Tohoku Journal of Experimental

Medicine. 165(2):137-145. 1991 （原著）

36. Sasano H, Suzuki T, Sano T, Kameya T, Sasano N, Nagura H. Adrenocortical oncocytoma. A true

nonfunctioning adrenocortical tumor. American Journal of Surgical Pathology. 15(10):949-956. 1991 （原著）

37. Kumamoto H, Ooya K, Sasano H. Immunohistochemical localization of c-myc oncogene protein correlated

with malignancy of oral epithelium. Japanese Journal of Oral Biology. 33:315-319. 1991 （原著）

38. Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano H, Kobayashi A, Hayami M, Fujii-Kuriyama Y. Two

regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region

of the rat P-4501A1 gene. EMBO Journal. 11(10):3663-3671. 1992 note: misspelled as Sasano K （原著）

39. Sasano H, Garrett CT. Oncogenes in gynecological tumors. Current Topics in Pathology. 85:357-372. 1992

（総説）

40. Yanai K, Watanabe T, Meguro K, Yokoyama H, Sato I, Sasano H, Itoh M, Iwata R, Takahashi T, Ido T.

Age-dependent decrease in histamine H1 receptor in human brains revealed by PET. Neuroreport.

3(5):433-436. 1992 （原著）

41. Sasano H, Goukon Y, Nishihira T, Nagura H. In situ hybridization and immunohistochemistry of p53 tumor

suppressor gene in human esophageal carcinoma. American Journal of Pathology. 141(3):545-550. 1992 （原

著）

42. Shiga C, Shiga K, Sasano H, Mori S. A point mutation of c-Ki-ras gene was found in human esophageal

carcinoma cell lines but not in primary esophageal carcinomas. Biochemical & Biophysical Research

Communications. 187(1):515-521. 1992 （原著）

43. Suzuki T, Sasano H, Sawai T, Tsunoda K, Nisikawa T, Abe K, Yoshinaga K, Nagura H. Small adrenocortical

tumors without apparent clinical endocrine abnormalities. Immunolocalization of steroidogenic enzymes.

Pathology Research & Practice. 188(7):883-889. 1992 （原著）

44. Sasano H, Fukushima K, Sasaki I, Matsuno S, Nagura H, Krozowski ZS. Immunolocalization of

mineralocorticoid receptor in human kidney, pancreas, salivary, mammary and sweat glands: a light and

electron microscopic immunohistochemical study. Journal of Endocrinology. 132(2):305-310. 1992 （原著）

45. Sasano H, Nagura H, Silverberg SG. Immunolocalization of c-myc oncoprotein in mucinous and serous

adenocarcinomas of the ovary. Human Pathology. 23(5):491-495. 1992 （原著）

46. Suzuki T, Sasano H, Nisikawa T, Rhame J, Wilkinson DS, Nagura H. Discerning malignancy in human

adrenocortical neoplasms: utility of DNA flow cytometry and immunohistochemistry. Modern Pathology.

5(3):224-231. 1992 （原著）

47. Miyazaki S, Sasano H, Suzuki T, Sawai T, Nishihira T, Mori S. Nucleolar organizer regions in human

esophageal disorders: comparison with proliferating cell nuclear antigen by immunostaining. Modern Pathology.

5:396-401. 1992 （原著）

48. Ito K, Sasano H, Ozawa N, Sato S, Silverberg SG, Yajima A. Immunolocalization of epidermal growth factor

receptor and c-erbB-2 oncogene product in human ovarian carcinoma. International Journal of Gynecological

Pathology. 11(4):253-257. 1992 （原著）

49. Sasano H, Miyazaki S, Gooukon Y, Nishihira T, Sawai T, Nagura H. Expression of p53 in human

esophageal carcinoma: an immunohistochemical study with correlation to proliferating cell nuclear antigen

expression. Human Pathology. 23(11):1238-1243. 1992 （原著）

50. Sasano H, Miyazaki S, Sawai T, Sasano N, Nagura H, Funahashi H, Aiba M, Demura H. Primary pigmented

nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of

steroidogenic enzymes in eight cases. Modern Pathology. 5(1):23-29. 1992 （原著）

51. Saitoh Y, Sasano H, Naganuma H, Ohtani H, Sasano N, Ohuchi A, Matsuno S. De novo expression of

aromatase in gastric carcinoma. Light and electron microscopic immunohistochemical and immunoblot study.

Pathology Research & Practice. 188(1-2):53-60. 1992 （原著）

52. Suzuki T, Sasano H, Sawai T, Mason JI, Nagura H. Immunohistochemistry and in situ hybridization of

P-45017 alpha (17 alpha-hydroxylase/17,20-lyase). Journal of Histochemistry & Cytochemistry. 40(7):903-908.

1992 （原著）

53. Sasano H, Miyazaki S, Nishihira T, Sawai T, Nagura H. The proliferative cell fraction in cytology specimens.

A study of human esophageal carcinoma. American Journal of Clinical Pathology. 98(2):161-166. 1992 （原著）

54. Sasano H, Nakashima N, Matsuzaki O, Kato H, Aizawa S, Sasano N, Nagura H. Testicular sex cord-stromal

lesions: immunohistochemical analysis of cytokeratin, vimentin and steroidogenic enzymes. Virchows Archiv - A,

Pathological Anatomy & Histopathology. 421(2):163-169. 1992 （原著）

55. Sasano H. New approaches in human adrenocortical pathology: Assessment of adrenocortical function in

surgical specimen of human adrenal glands. Endocrine Pathology. 3(1):4-13. 1992 （原著）

56. Miyazaki S, Sasano H, Shiga K, Sawai T, Nishihira T, Okamoto H, Mori S. Analysis of c-myc oncogene in

human esophageal carcinoma: immunohistochemistry, in situ hybridization and northern and southern blot

studies. Anticancer Research. 12(5):1747-1755. 1992 （原著）

57. Kimura N, Mizokami A, Oonuma T, Sasano H, Nagura H. Immunocytochemical localization of androgen

receptor with polyclonal antibody in paraffin-embedded human tissues. Journal of Histochemistry &

Cytochemistry. 41(5):671-678. 1993 （原著）

58. Mitchell A, Scheithauer BW, Sasano H, Hubbard EW, Ebersold MJ. Symptomatic intradural adrenal

adenoma of the spinal nerve root: report of two cases. Neurosurgery. 32(4):658-661. 1993 （原著）

59. Sasano H, Suzuki T, Nagura H, Nishikawa T. Steroidogenesis in human adrenocortical carcinoma:

biochemical activities, immunohistochemistry, and in situ hybridization of steroidogenic enzymes and

histopathologic study in nine cases. Human Pathology. 24(4):397-404. 1993 （原著）

60. Takahashi K, Mouri T, Totsune K, Sone M, Murakami O, Itoi K, Ohneda M, Sasano H, Sasano N, Kawauchi

H. Human melanin-concentrating hormone in the human brain. Annals of the New York Academy of Sciences.

680:619-620. 1993 （原著）

61. Jiko K, Sasano H, Ito K, Ozawa N, Sato S, Yajima A. Immunohistochemical and in situ hybridization analysis

of p53 in human endometrial carcinoma of the uterus. Anticancer Research. 13(2):305-310. 1993 （原著）

62. Sasano H, Miuazaki S, Shiga K, Goukon Y, Nishihira T, Nagura H. Glutathione S-transferase in human

esophageal carcinoma. Anticancer Research. 13(2):363-368. 1993 （原著）

63. Mouri T, Takahashi K, Kawauchi H, Sone M, Totsune K, Murakami O, Itoi K, Ohneda M, Sasano H, Sasano

N. Melanin-concentrating hormone in the human brain. Peptides. 14(3):643-646. 1993 （原著）

64. Sato S, Jiko K, Ito K, Ozawa N, Yajima A, Miyazaki S, Sasano H. Expression of c-myc mRNA and protein in

human endometrial carcinoma; simultaneous study of in situ hybridization and immunohistochemistry. Tohoku

Journal of Experimental Medicine. 170(4):229-234. 1993 （原著）

65. Sasano H, Date F, Imatani A, Asaki S, Nagura H. Double immunostaining for c-erbB-2 and p53 in human

stomach cancer cells. Human Pathology. 24(6):584-589. 1993 （原著）

66. Satoh K, Sasano H, Shimosegawa T, Koizumi M, Yamazaki T, Mochizuki F, Kobayashi N, Okano T, Toyota T,

Sawai T. An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting

neoplasms and in ductal cell carcinomas of the pancreas. Cancer. 72(1):51-56. 1993 （原著）

67. Shiga K, Shiga C, Sasano H, Miyazaki S, Yamamoto T, Yamamoto M, Hayashi N, Nishihira T, Mori S.

Expression of c-erbB-2 in human esophageal carcinoma cells: overexpression correlated with gene

amplification or with GATA-3 transcription factor expression. Anticancer Research. 13(5A):1293-1301. 1993 （原

著）

68. Shikano K, Sasano H, Ito K, Ozawa N, Tase T, Sato S, Yajima A. The correlation between HPV infection and

cell proliferative activity in uterine cervical adenocarcinoma. Tohoku Journal of Experimental Medicine.

169(4):279-288. 1993 （原著）

69. Sasano H, Nagura H, Watanabe K, Ito K, Tsuiki A, Sato S, Yajima A, Kusakabe M, Sakakura T. Tenascin

expression in normal and abnormal human endometrium. Modern Pathology. 6(3):323-326. 1993 （原著）

70. Sasano H, Date F, Itakura Y, Goukon Y, Nishihira T, Nagura H. Confocal laser scanning microscopy in

cytopathology. Modern Pathology. 6(5):625-629. 1993 （原著）

71. Suzuki T, Sasano H, Aoki H, Nagura H, Sasano N, Sano T, Saito M, Watanuki T, Kato H, Aizawa S.

Immunohistochemical comparison between anaplastic seminoma and typical seminoma. Acta Pathologica

Japonica. 43(12):751-757. 1993 （原著）

72. Tamura M, Sasano H, Suzuki T, Fukaya T, Watanabe T, Kusakabe M, Sakakura T, Yajima A. Distribution of

tenascin in normal cycling human ovary. Human Reproduction. 8(12):2015-2018. 1993 （原著）

73. Suzuki T, Sasano H, Tamura M, Aoki H, Fukaya T, Yajima A, Nagura H, Mason JI. Temporal and spatial

localization of steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and

immunohistochemical study. Molecular & Cellular Endocrinology. 97(1-2):135-143. 1993 （原著）

74. Suzuki T, Sasano H, Murakami O, Nagura H. A case of ruptured dissecting aneurysm 5 years after pituitary

microsurgical treatment of Cushing's disease: autopsy findings in the hypothalamic-pituitary-adrenal axis.

Endocrine Journal. 40(5):613-618. 1993 （原著）

75. Ito K, Sasano H, Watanabe K, Ozawa N, Sato S, Yajima A. Immunohistochemical study of PCNA

(proliferating cell nuclear antigen) in normal and abnormal endometrium. International Journal of Gynecological

Cancer. 3(2):122-127. 1993 （原著）

76. Bennett NC, Jarvis JUM, Millar RP, Sasano H, Ntshinga KV. Reproductive suppression in eusocial

cryptomys damarensis colonies: socially-included infertility in females. Journal of Zoology. 233(4):617-630.

1994 （原著）

77. Costa MJ, Morris R, Sasano H. Sex steroid biosynthesis enzymes in ovarian sex-cord stromal tumors.

International Journal of Gynecological Pathology. 13(2):109-119. 1994 （原著）

78. Sasano H, Suzuki T, Nagura H. ACTH-independent macronodular adrenocortical hyperplasia:

immunohistochemical and in situ hybridization studies of steroidogenic enzymes. Modern Pathology.

7(2):215-219. 1994 （原著）

79. Itakura Y, Sasano H, Shiga C, Furukawa Y, Shiga K, Mori S, Nagura H. Epidermal growth factor receptor

overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic

findings and DNA amplification. Cancer. 74(3):795-804. 1994 （原著）

80. Tatsuno I, Nishikawa T, Sasano H, Shizawa S, Iwase H, Satoh S. Interleukin 6-producing gastric carcinoma

with fever, hypergammaglobulinemia, and plasmacytosis in bone marrow. Gastroenterology. 107(2):543-547.

1994 （症例）

81. Ito K, Watanabe K, Nasim S, Sasano H, Sato S, Yajima A, Silverberg SG, Garrett CT. Prognostic

significance of p53 overexpression in endometrial cancer. Cancer Research. 54(17):4667-4670. 1994 （原著）

82. Takahashi K, Totsune K, Murakami O, Satoh F, Sone M, Ohneda M, Sasano H, Mouri T. Pituitary adenylate

cyclase activating polypeptide (PACAP)-like immunoreactivity in human hypothalamus: co-localization with

arginine vasopressin. Regulatory Peptides. 50(3):267-275. 1994 （原著）

83. Goukon Y, Sasano H, Nishihira T, Nagura H, Mori S. p53 overexpression in human esophageal carcinoma:

a correlation with tumor DNA ploidy and two parameter flow cytometric study. Anticancer Research.

14(3B):1305-1312. 1994 （原著）

84. Sasano H, Watanabe K, Ito K, Sato S, Yajima A. New concepts in the diagnosis and prognosis of

endometrial carcinoma. Pathology Annual. 29 ( Pt 2):31-49. 1994 （総説）

85. Totsune K, Takahashi K, Murakami O, Satoh F, Sone M, Saito T, Sasano H, Mouri T, Abe K. Natriuretic

peptides in the human kidney. Hypertension. 24(6):758-762. 1994 （原著）

86. Goukon Y, Sasano H, Nishihira T, Mori S, Nagura H. p53 immunolocalization in cytology specimens: a study

in human esophageal carcinoma. Diagnostic Cytopathology. 11(2):113-118. 1994. （原著）

87. Sohma Y, Suzuki T, Sasano H, Nagura H, Nose M, Yamamoto T. Increased mRNA for CD63 antigen in

atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Cell Structure & Function. 19:219-225.

1994 （原著）

88. Sasano H, Suzuki T, Shizawa S, Kato K, Nagura H. Transforming growth factor alpha, epidermal growth

factor, and epidermal growth factor receptor expression in normal and diseased human adrenal cortex by

immunohistochemistry and in situ hybridization. Modern Pathology. 7(7):741-746. 1994 （原著）

89. Fukushima K, Sasano H, Sasaki I, Nagura H, Funayama Y, Matsuno S. Increased expression of

mineralocorticoid receptor in human ileum after total colectomy: immunohistochemical and immunoblotting

studies. Tohoku Journal of Experimental Medicine. 173(4):383-390. 1994 （原著）

90. Itakura Y, Sasano H, Mori S, Nagura H. DNA ploidy in human esophageal squamous dysplasias and

squamous cell carcinomas as determined by image analysis. Modern Pathology. 7(8):867-873. 1994 （原著）

91. Takahashi K, Suzuki H, Kayama T, Suzuki Y, Yoshimoto T, Sasano H, Shibahara S. Multiple transcripts of

the neurofibromatosis type 1 gene in human brain and in brain tumours. Clinical Science. 87(5):481-485. 1994

（原著）

92. Sohma Y, Suzuki T, Sasano H, Nagura H, Nose M, Yamamoto T. Expression of mRNA for matrix

gamma-carboxyglutamic acid protein during progression of atherosclerosis in aortae of Watanabe heritable

hyperlipidemic rabbits. Journal of Biochemistry. 116(4):747-751. 1994 （原著）

93. Sasano H. Emerging new technologies for evaluating endometrial hyperplasia and carcinoma. Advances in

Pathology and Laboratory Medicine. 7:517-531. 1994 （総説）

94. Sasano H, Nagura H, Harada N, Goukon Y, Kimura M. Immunolocalization of aromatase and other

steroidogenic enzymes in human breast disorders. Human Pathology. 25(5):530-535. 1994 （原著）

95. Suzuki T, Sasano H, Sasaki H, Fukaya T, Nagura H. Quantitation of P450 aromatase immunoreactivity in

human ovary during the menstrual cycle: relationship between the enzyme activity and immunointensity. Journal

of Histochemistry & Cytochemistry. 42(12):1565-1573. 1994 （原著）

96. Suzuki T, Sasano H, Kimura N, Tamura M, Fukaya T, Yajima A, Nagura H. Immunohistochemical distribution

of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship

to expression of steroidogenic enzymes. Human Reproduction. 9(9):1589-1595. 1994 （原著）

97. Sasano H. Localization of steroidogenic enzymes in adrenal cortex and its disorders. Endocrine Journal.

41(5):471-482. 1994 （総説）

98. Nishikawa T, Yoshida A, Omura M, Sasano H, Noda M. Cholera toxin can ADP-ribosylate Gs as well as Gi in

ACTH-unresponsive human adrenocortical cancer. Endocrine Journal. 41(5):593-597. 1994 （原著）

99. Tamura M, Sasano H, Suzuki T, Fukaya T, Watanabe T, Aoki H, Nagura H, Yajima A. Immunohistochemical

localization of growth hormone receptor in cyclic human ovaries. Human Reproduction. 9(12):2259-2262. 1994

（原著）

100. Sasano H. Functional pathology of human ovarian steroidogenesis: Normal cycling ovary and

steroid-producing neoplasms. Endocrine Pathology. 5:81-89. 1994 （原著）

101. Sasano H, Kato K, Nagura H, Parkkila S, Parkkila A-K, Rajaniemi H, Sugai N. Carbonic anhydrases in the

human adrenal gland and its disorders: Immunohistochemical and biochemical studies of the enzymes.

Endocrine Pathology. 5:100-106. 1994 （原著）

102. Sasano H. Application of mRNA in situ hybridization to surgical pathology materials. Acta Histochemica

Cytochemica. 27(6):567-571. 1994 （総説）

103. Sasano H. In situ end labeling and its application to the study of endocrine disease: How can we study

programmed cell death in surgical pathology materials? Endocrine Pathology. 2:87-89. 1994 (editorial)

104. Kubota T, Sasano N, Abe O, Nakao I, Kawamura E, Saito T, Endo M, Kimura K, Demura H, Sasano H,

Nagura H, Ogawa N, Hoffman RM. Potential of the histoculture drug-response assay to contribute to cancer

patient survival. Clinical Cancer Research. 1(12):1537-1543. 1995 （原著）

105. Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, Abe K, Miura Y, Hayashi Y, Sasano H.

Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma,

ganglioneuroblastoma and neuroblastoma. Journal of Clinical Endocrinology & Metabolism. 80 (5):1750-1752.

1995 （原著）

106. Sohma Y, Sasano H, Shiga R, Saeki S, Suzuki T, Nagura H, Nose M, Yamamoto T. Accumulation of

plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Proceedings of the National

Academy of Sciences of the United States of America. 92(11):4937-4941. 1995 （原著）

107. Takahashi K, Suzuki H, Totsune K, Murakami O, Satoh F, Sone M, Sasano H, Mouri T, Shibahara S.

Melanin-concentrating hormone in human and rat. Neuroendocrinology. 61(5):493-498. 1995 （原著）

108. Sasano H, Shizawa S, Suzuki T, Takayama K, Fukaya T, Morohashi K, Nagura H. Ad4BP in the human

adrenal cortex and its disorders. Journal of Clinical Endocrinology & Metabolism. 80:2378-2380. 1995 （原著）

109. Niikura H, Sasano H, Matsunaga G, Watanabe K, Ito K, Sato S, Yajima A. Prognostic value of epidermal

growth factor receptor expression in endometrioid endometrial carcinoma. Human Pathology. 26:892-896. 1995

（原著）

110. Sasano H, Shizawa S, Nagura H. Adrenocortical cytopathology. American Journal of Clinical Pathology.

104(2):161-166. 1995 （原著）

111. Takayama K, Sasano H, Fukaya T, Morohashi K, Suzuki T, Tamura M, Costa MJ, Yajima A.

Immunohistochemical localization of Ad4-binding protein with correlation to steroidogenic enzyme expression in

cycling human ovaries and sex cord stromal tumors. Journal of Clinical Endocrinology & Metabolism. 80

(9):2815-2821. 1995 （原著）

112. Sasano H, Shizawa S, Suzuki T, Takayama K, Fukaya T, Morohashi K, Nagura H. Transcription factor

adrenal 4 binding protein as a marker of adrenocortical malignancy. Human Pathology. 26(10):1154-1156. 1995

（原著）

113. Tamura M, Sasano H, Suzuki T, Fukaya T, Funayama Y, Takayama K, Takaya R, Yajima A. Expression of

epidermal growth factors and epidermal growth factor receptor in normal cycling human ovaries. Human

Reproduction. 10(7):1891-1896. 1995 （原著）

114. Watanabe K, Sasano H, Harada N, Ozaki M, Niikura H, Sato S, Yajima A. Aromatase in human endometrial

carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. American

Journal of Pathology. 146(2):491-500. 1995 （原著）

115. Sasano H, Imatani A, Shizawa S, Suzuki T, Nagura H. Cell proliferation and apoptosis in normal and

pathologic human adrenal. Modern Pathology. 8(1):11-17. 1995 （原著）

116. Murakami Y, Sasaki M, Sasano H, Suzuki T, Kitamura N, Tomoi M, Yorifuji H, Koshimura K, Kato Y. Young

female patient with testosterone-producing adrenocortical adenoma also showing signs of subclinical Cushing's

syndrome. Endocrine Journal. 42(2):283-288. 1995 （原著）

117. Sasano H, Sato F, Shizawa S, Nagura H, Coughtrie MW. Immunolocalization of dehydroepiandrosterone

sulfotransferase in normal and pathologic human adrenal gland. Modern Pathology. 8(9):891-896. 1995 （原著）

118. Murakami O, Satoh F, Takahashi K, Totsune K, Sone M, Ohneda M, Abe K, Suzuki T, Sasano H, Mouri T.

Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent

bilateral adrenocortical macronodular hyperplasia: pituitary-adrenocortical function and immunohistochemistry.

Internal Medicine. 34(11):1074-1081. 1995 （原著）

119. Wada N, Kubo M, Kijima H, Yamane Y, Nishikawa T, Sasano H, Koike T. A case of

deoxycorticosterone-producing adrenal adenoma. Endocrine Journal. 42 (5):637-642. 1995 （症例）

120. Sasano H. In situ analysis of DNA abnormalities in human carcinoma: Approaches using surgical

pathology materials. Acta Histochemica Cytochemica. 28(6):575-580. 1995 （解説）

121. Nagasaka S, Kubota K, Motegi T, Hayashi E, Ohta M, Takahashi K, Takahashi T, Iwasaki Y, Koike M,

Nishikawa T, Sasano H, Murakami T. A case of silent 21-hydroxylase deficiency with persistent adrenal

insufficiency after removal of an adrenal incidentaloma. Clinical Endocrinology. 44(1):111-116. 1996 （症例）

122. Carpen O, Simberg N, Sasano H, Saksela E. Virilizing ovarian leiomyoma: androgen production by lining

stromal cells. Acta Obstetricia et Gynecologica Scandinavica. 75(1):72-76. 1996 （症例）

123. Niikura H, Sasano H, Kaga K, Sato S, Yajima A. Expression of epidermal growth factor family proteins and

epidermal growth factor receptor in human endometrium. Human Pathology. 27(3):282-289. 1996 （原著）

124. Abe K, Sasano H, Itakura Y, Nishihira T, Mori S, Nagura H. Basaloid-squamous carcinoma of the

esophagus. A clinicopathologic, DNA ploidy, and immunohistochemical study of seven cases. American Journal

of Surgical Pathology. 20(4):453-461. 1996 （原著）

125. Oka H, Kameya T, Sasano H, Aiba M, Kovacs K, Horvath E, Yokota Y, Kawano N, Yada K. Pituitary

choristoma composed of corticotrophs and adrenocortical cells in the sella turcica. Virchows Archiv.

427(6):613-617. 1996 （症例）

126. Uyeno S, Komura J, Tawa R, Aoki Y, Nata M, Sasano H, Nakura H, Sagisaka K, Sakurai H, Kayama T,

Yoshimoto T, Ono T. Alteration of c-fos gene methylation in human gliomas. Molecular Carcinogenesis.

16(2):91-100. 1996 （原著）

127. Nishikawa T, Sasano H, Omura M, Suematsu S. Regulation of expression of the steroidogenic acute

regulatory (StAR) protein by ACTH in bovine adrenal fasciculata cells. Biochemical & Biophysical Research

Communications. 223 (1):12-18. 1996 （原著）

128. Sasano H, Kaga K, Sato S, Yajima A, Nagura H. Adrenal 4-binding protein in common epithelial and

metastatic tumors of the ovary. Human Pathology. 27 (6):595-598. 1996 （原著）

129. Yokoyama J, Shiga K, Sasano H, Suzuki M, Takasaka T. Abnormalities and the implication of

retinoblastoma locus and its protein product in head and neck cancers. Anticancer Research. 16(2):641-644.

1996 （原著）

130. Minami S, Sugihara H, Sato J, Tatsukuchi A, Sugisaki Y, Sasano H, Wakabayashi I. ACTH independent

Cushing's syndrome occurring in siblings. Clinical Endocrinology. 44(4):483-488. 1996 （原著）

131. Imatani A, Sasano H, Asaki S, Toyota T, Saito M, Masuda T, Nagura H. Analysis of p53 abnormalities in

endoscopic gastric biopsies. Anticancer Research. 16(4A):2049-2056. 1996 （原著）

132. Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S. Expression of heme oxygenase isozyme mRNAs

in the human brain and induction of heme oxygenase-1 by nitric oxide donors. Journal of Neurochemistry.

67(2):482-489. 1996 （原著）

133. Smith RE, Maguire JA, Stein-Oakley AN, Sasano H, Takahashi K, Fukushima K, Krozowski ZS.

Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues. Journal of Clinical


134. Funayama Y, Sasano H, Suzuki T, Tamura M, Fukaya T, Yajima A. Cell turnover in normal cycling human

ovary. Journal of Clinical Endocrinology & Metabolism. 81(2):828-834. 1996 （原著）

135. Wada N, Kubo M, Kijima H, Ishizuka T, Saeki T, Koike T, Sasano H. Adrenocorticotropin-independent

bilateral macronodular adrenocortical hyperplasia: immunohistochemical studies of steroidogenic enzymes and

post-operative course in two men. European Journal of Endocrinology. 134(5):583-587. 1996 （原著）

136. Kaga K, Sasano H, Harada N, Ozaki M, Sato S, Yajima A. Aromatase in human common epithelial ovarian

neoplasms. American Journal of Pathology. 149(1):45-51. 1996 （原著）

137. Imatani A, Sasano H, Yabuki N, Kato K, Ohara S, Asaki S, Toyota T, Nagura H. In situ analysis of tissue

dynamics and p53 expression in human gastric mucosa. Journal of Pathology. 179(1):39-42. 1996 （原著）

138. Sasano H, Maehara I, Ueno J, Orikasa S, Nagura H. Leydig cell tumor of the testis: analysis of

testosterone production and secretion by three-dimensional histoculture. Endocrine Journal. 43(1):73-78. 1996

（症例）

139. Tobinaga J, Imai T, Funahashi H, Tanaka Y, Wada M, Morita T, Yamada F, Tsukamura K, Oiwa M, Kikumori

T, Sasano H, Takagi H. Incidentally discovered adrenocortical adenomas are not fully nonfunctioning:

immunohistochemica and dispersed adrenocortical cell study. Endocrine Journal. 43(1):79-86. 1996 （原著）

140. Miura K, Yasuda K, Yanase T, Yamakita N, Sasano H, Nawata H, Inoue M, Fukaya T, Shizuta Y. Mutation

of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having

glucocorticoid-responsive hyperaldosteronism: with a review of Japanese patients with mutations of CYP17.

Journal of Clinical Endocrinology & Metabolism. 81(10):3797-3801. 1996 （症例）

141. Takayama K, Fukaya T, Sasano H, Funayama Y, Suzuki T, Takaya R, Wada Y, Yajima A.

Immunohistochemical study of steroidogenesis and cell proliferation in polycystic ovarian syndrome. Human

Reproduction. 11(7):1387-1392. 1996 （原著）

142. Itakura Y, Sasano H, Date F, Kato K, Sekine H, Mori S, Nagura H. DNA ploidy, P53 expression, and cellular

proliferation in normal epithelium and squamous dysplasia of non-cancerous and cancerous human oesophagi.

Anticancer Research. 16(1):201-208. 1996 （原著）

143. Hiramatsu M, Maehara I, Orikasa S, Sasano H. Immunolocalization of oestrogen and progesterone

receptors in prostatic hyperplasia and carcinoma. Histopathology. 28(2):163-168. 1996 （原著）

144. Nakazumi H, Sasano H, Maehara I, Ozaki M, Tezuka F, Orikasa S. Estrogen metabolism and impaired

spermatogenesis in germ cell tumors of the testis. Journal of Clinical Endocrinology & Metabolism.

81(3):1289-1295. 1996 （原著）

145. Sasano H, Kimura M, Shizawa S, Kimura N, Nagura H. Aromatase and steroid receptors in gynecomastia

and male breast carcinoma: an immunohistochemical study. Journal of Clinical Endocrinology & Metabolism.

81(8):3063-3067. 1996 （原著）

146. Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, Sasano H, Mouri T.

Immunocytochemical localization of adrenomedullin-like immunoreactivity in the human hypothalamus and the

adrenal gland. Neuroscience Letters. 203(3):207-210. 1996 （原著）

147. Matsuda A, Beniko M, Ikota A, Yamazaki M, Koizumi S, Mizumoto H, Watanabe T, Matsuya K, Kunita H,

Mashio Y, Sasano H. Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas.

Internal Medicine. 35(12):970-975. 1996 （症例）

148. Yabuki N, Sasano H, Kato K, Ohara S, Toyota T, Nagura H, Miyaike M, Nozaki N, Kikuchi A.

Immunohistochemical study of DNA topoisomerase II in human gastric disorders. American Journal of

Pathology. 149(3):997-1007. 1996 （原著）

149. Sasano H, Suzuki T, Niikura H, Kaga K, Sato S, Yajima A, Rainey WE, Nagura H. 17 beta-hydroxysteroid

dehydrogenase in common epithelial ovarian tumors. Modern Pathology. 9(4):386-391. 1996 （原著）

150. Nakazumi H, Sasano H, Maehara I, Orikasa S. Transforming growth factor-alpha, epidermal growth factor,

and epidermal growth factor receptor in human testis obtained from biopsy and castration:

immunohistochemical study. Tohoku Journal of Experimental Medicine. 178(4):381-388. 1996 （原著）

151. Sasano H, Kaga K, Sato S, Yajima A, Nagura H, Harada N. Aromatase cytochrome P450 gene expression

in endometrial carcinoma. British Journal of Cancer. 74(10):1541-1544. 1996 （原著）

152. Ito K, Watanabe K, Nasim S, Sasano H, Sato S, Yajima A. Silverberg SG. Garrett CT. K-ras point mutations

in endometrial carcinoma: effect on outcome is dependent on age of patient. Gynecologic Oncology.

63(2):238-246. 1996 （原著）

153. Goto T, Murakami O, Sato F, Haraguchi M, Yokoyama K, Sasano H. Oestrogen producing adrenocortical

adenoma: clinical, biochemical and immunohistochemical studies. Clinical Endocrinology. 45(5):643-648. 1996

（症例）

154. Sasano H, Frost AR, Saitoh R, Harada N, Poutanen M, Vihko R, Bulun SE, Silverberg SG, Nagura H.

Aromatase and 17 beta-hydroxysteroid dehydrogenase type 1 in human breast carcinoma. Journal of Clinical


155. Itakura Y, Sasano H, Abe K, Furukawa Y, Mori S, Nagura H. Cytokeratin immunolocalization and lectin

binding studies in oesophageal squamous dysplasia. Histopathology. 29(1):3-10. 1996 （原著）

156. Watanabe N, Tsunoda K, Sasano H, Omata K, Imai Y, Ito S, Abe K. Bilateral aldosterone-producing

adenomas in two patients diagnosed by immunohistochemical analysis of steroidogenic enzymes. Tohoku

Journal of Experimental Medicine. 179(2):123-129. 1996 （原著）

157. Morio H, Terano T, Yamamoto K, Tomizuka T, Oeda T, Saito Y, Tamura Y, Sasano H. Serum levels of

dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison

with adrenal Cushing's syndrome and non-functional adrenal tumor. Endocrine Journal. 43(4):387-396. 1996

（原著）

158. Gell JS, Atkins B, Margraf L, Mason JI, Sasano H, Rainey WE, Carr BR. Adrenarche is associated with

decreased 3 beta-hydroxysteroid dehydrogenase expression in the adrenal reticularis. Endocrine Research.

22(4):723-728. 1996 （原著）

159. Hatori M, Sasano H, Hoshikawa K, Sakuma T, Okaniwa G, Sakurai M. Skeletal muscle metastasis

secondary to adenocarcinoma of the lung. Orthopaedics. 4:145-147. 1996 （症例）

160. Niikura H, Sasano H, Sato S, Yajima A. Expression of epidermal growth factor-related proteins and

epidermal growth factor receptor in common epithelial ovarian tumors. International Journal of Gynecological

Pathology. 16(1):60-68. 1997 （原著）

161. Itakura Y, Sasano H, Mori S, Nagura H, Shimizu S. Tissue subtraction DNA in situ hybridization (TSDISH):

in situ detection of DNA abnormalities in formalin-fixed paraffin-embedded tissue sections by subtraction

hybridization with whole genomic DNA. Anticancer Research. 17(1A):121-128. 1997 （原著）

162. Kimura K, Sasano H, Shimosegawa T, Kato K, Noguchi T, Mochizuki S, Sawai T, Koizumi M, Toyota T,

Nagura H. Ultrastructural and confocal laser scanning microscopic examination of TUNEL-positive cells.

Journal of Pathology. 181(2):235-242. 1997 （原著）

163. Kang MJ, Fujino T, Sasano H, Minekura H, Yabuki N, Nagura H, Iijima H, Yamamoto TT. A novel

arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis.

Proceedings of the National Academy of Sciences of the United States of America. 94(7):2880-2884. 1997 （原

著）

164. Hiramatsu M, Maehara I, Ozaki M, Harada N, Orikasa S, Sasano H. Aromatase in hyperplasia and

carcinoma of the human prostate. Prostate. 31(2):118-124. 1997 （原著）

165. Satoh F, Murakami O, Takahashi K, Ueno J, Nishikawa T, Abe K, Mouri T, Sasano H. Double adenomas

with different pathological and hormonal features in the left adrenal gland of a patient with Cushing's syndrome.

Clinical Endocrinology. 46(2):227-234. 1997 （症例）

166. Shizawa S, Sasano H, Suzuki T, Ishii H, Takeda T, Nagura H. Low-grade adenosquamous carcinoma of

the breast: a case study with cytologic findings and review of the literature. Pathology International.

47(4):264-267. 1997 （症例）

167. Ito K, Sasano H, Yabuki N, Matsunaga G, Sato S, Kikuchi A, Yajima A, Nagura H. Immunohistochemical

study of Ki-67 and DNA topoisomerase II in human endometrium. Modern Pathology. 10(4):289-294. 1997 （原

著）

168. Sasano H, Imaizumi H, Nagura H. Juvenile granulosa cell tumor discovered during pregnancy: case study

with immunohistochemical study of steroidogenesis. Pathology International. 47(5):325-328. 1997 （症例）

169. Yasuda M, Itoh J, Muramatsu T, Shinozuka T, Sasano H, Tsutsumi Y, Osamura RY. Subcellular organelle

analysis applying confocal laser scanning microscopy to the steroid-producing epithelial ovarian tumor.

Pathology International. 47(5):336-338. 1997 （原著）

170. Yabuki N, Sasano H, Tobita M, Imatani A, Hoshi T, Kato K, Ohara S, Asaki S, Toyota T, Nagura H. Analysis

of cell damage and proliferation in Helicobacter pylori-infected human gastric mucosa from patients with gastric

adenocarcinoma. American Journal of Pathology. 151(3):821-829. 1997 （原著）

171. Sasano H, Sato S, Yajima A, Akama J, Nagura H. Adrenal rest tumor of the broad ligament: case study

with immunohistochemical study of steroidogenic enzymes. Pathology International. 47(7):493-496. 1997 （症

例）

172. Sasano H, Shizawa S, Nagura H, Yamaki T. Mucinous adenocarcinoma arising in a giant urachal cyst

associated with pseudomyxoma peritonei and stromal osseous metaplasia. Pathology International.

47(7):502-505. 1997 （症例）

173. Yoshimoto M, Kawaguchi T, Mori R, Kinoshita E, Baba T, Tajima T, Fujieda K, Suzuki T, Sasano H. Pubertal

changes in testicular 3 beta-hydroxysteroi dehydrogenase activity in a male with classical 3 beta-hydroxysteroid

dehydrogenase deficiency showing spontaneous secondary sexual maturation. Hormone Research.

48(2):83-87. 1997 （原著）

174. Mayama T, Mori T, Abe K, Sasano H, Nishihira T, Satomi S, Horii A. Analysis of the p53 gene mutations in

patients with multiple primary cancers of the oesophagus. European Journal of Surgical Oncology.

23(4):298-303. 1997 （原著）

175. Abe S, Sasano H, Katoh K, Ohara S, Arikawa T, Noguchi T, Asaki S, Yasui W, Tahara E, Nagura H, Toyota

T. Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa.

Digestive Diseases & Sciences. 42(6):1199-1209. 1997 （原著）

176. Sasano H, Frost AR, Saitoh R, Matsunaga G, Nagura H, Krozowski ZS, Silverberg SG. Localization of

mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase type II in human breast and its disorders.

Anticancer Research. 17(3C):2001-2007. 1997 （原著）

177. Satoh F, Takahashi K, Murakami O, Totsune K, Ohneda M, Mizuno Y, Sone M, Miura Y, Takase S, Hayashi

Y, Sasano H, Mouri T. Cerebellin and cerebellin mRNA in the human brain. adrenal glands and the tumour

tissues of adrenal tumour, ganglioneuroblastoma and neuroblastoma. Journal of Endocrinology. 154(1):27-34.

1997 （原著）

178. Takaya R, Fukaya T, Sasano H, Suzuki T, Tamura M, Yajima A. Macrophages in normal cycling human

ovaries. immunohistochemical localization and characterization. Human Reproduction. 12(7):1508-1512. 1997

（原著）

179. Makino S, Chikazawa H, Yorimitsu A, Suehiro T, Hashimoto K, Ohashi Y, Morioka M, Sasano H. A rare

case of Cushing's syndrome due to bilateral adrenocortical adenomas. Endocrine Journal. 44(4):533-540. 1997

（症例）

180. Sasano H, Date F, Yamamoto H, Nagura H. Angiomyoblastoma of the vulva: case study with

immunohistochemica. ultrastructural and DNA ploidy studies and a review of the literature. Pathology

International. 47(9):647-650. 1997 （症例）

181. Iino K, Sasano H, Nagura H, Watanabe F, Iwabuchi M, Ozawa M, Oki Y, Yoshimi T. Adrenal adenoma with

bilateral adrenocortical nodular changes in a patient with Cushing 's syndrome. Clnical Endocronology.

47(3):371-375. 1997 （症例）

182. Iino K, Sasano H, Yabuki N, Oki Y, Kikuchi A, Yoshimi T, Nagura H. DNA topoisomerase II alpha and Ki-67

in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.

Modern Pathology. 10(9):901-907. 1997 （原著）

183. Sasano H, Uzuki M, Sawai T, Nagura H, Matsunaga G, Kashimoto O, Harada N. Aromatase in human

bone tissue. Journal of Bone and Mineral Research. 12(9):1416-1423. 1997 （原著）

184. Sasano H, Ozaki M. Aromatase expression and its localization in human breast cancer. Journal of Steroid

Biochemistry and Molecular Biology. 61(3-6):293-298. 1997 （解説）

185. Hirasawa G, Sasano H, Takahashi K, Fukushima K, Suzuki T, Hiwatashi N, Toyota T, Krozowski ZS,

Nagura H. Colocalization of 11-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human

epithelia. Journal of Clincal Endocrinology and Metabolism. 82(11):3859-3863. 1997 （原著）

186. Iino K, Sasano H, Oki Y, Andoh N, Ryong-Woon Shin, Kitamoto T, Totsune K, Takahashi K, Suzuki H,

Nagura H, Yoshimi T. Urocortin expression in human pituitary gland and pituitary adenoma. Journal of Clinical

Endocrinology and Metabolism. 82(11):3842-3850. 1997 （原著）

187. Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y. Molecular cloning and characterization of rat ST1B1

and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. Journal of Biochemistry.

122(5):1052-1061. 1997 （原著）

188. Ito K, Sasano H, Matsunaga G, Sato S, Yajima A, Nasim S, Garret CT. Correlations between p21

expression and clinicopathological findings, p53 gene and protein alterations, and survival in patients with

endometrial carcinoma. Journal of Pathology. 183(3):318-324. 1997 （原著）

189. Shoji M, Kimura T, Ota K, Yamaji T, Ishibashi M, Ohta M, Sasano H, Kawarabayashi Y, Kimura N, Funyu T,

Mori T, Sahata T. Genotype analysis of prepro-vasopressin signal peptide in vasopressin-producing and

-non-producing lung tumors. Life Science. 61(26):2561-2566. 1997 （原著）

190. Sasano H, Frost AR, Saitoh R, Taniyama Y, Nagura H, Matsunaga G, Takehana K, Kimura M, Silverberg

SG. Immunolocalization of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human breast

carcinoma. Anticancer Research. 17(5A):3685-3690. 1997 （原著）

191. Sone M, Takahashi K, Satoh F, Murakami O, Totsune K, Ohneda M, Sasano H, Ito H, Mouri T. Specific

adrenomedullin binding sites in the human brain. Peptides. 18(8):1125-1129. 1997 （原著）

192. Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H,

Wakabayashi I. Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological

features. Internal Medicine. 36(11):804-809. 1997 （症例）

193. Watanabe T, Fukaya T, Yajima A, Sasano H. Expression of epidermal growth factor (EGF) family and

expression of epidermal growth factor receptor (EGFR) in human chorionic villi. Trophoblast Research. 9:41-52.

1997 （原著）

194. Kurihara Y, Kasahara K, Sasano H, Tsutsumi Y. Ovarian endometrioid adenocarcinoma associated with

steroidogenic foamy stromal cells. Pathology International. 47(12):883-888. 1997 （原著）

195. Wakatsuki S, Sasano H, Matsui T, Nagashima K, Toyota T, Horii A. Adrenocortical tumor in a patient with

familial adenomatous polyposis: a case associated with a complete inactivating mutation of the APC gene and

unusual histological features. Human Pathology. 29(3):302-306. 1998 （症例）

196. Yasuda M, Itoh J, Hirasawa T, Hirazono K, Shinozuka T, Sasano H, Osamura RY. Serous borderline

ovarian tumor with functioning stroma in a postmenopausal woman: immunohistochemical analysis of

steroidogenic pathway. International Journal of Gynecolical Pathology. 17(1):75-78. 1998 （症例）

197. Kimura K, Shimosegawa T, Sasano H, Abe R, Satoh A, Masamune A, Koizumi M, Nagura H, Toyota T.

Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats.

Gastroenterology. 114(2):372-381. 1998 （原著）

198. Yanase T, Sasano H, Yubisui T, Sakai Y, Takayanagi R, Nawata H. Immunohistochemical study of

cytochrome b5 in human adrenal gland and in adrenocortical adenoma from patients with Cushing's syndrome.


199. Tanoguchi K, Sasano H, Yabuki N, Kikuchi A, Ito K, Sato S, Yajima A. Immunohistochemical and

two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma

and germ cell tumor. Modern Pathology. 11(2):186-193. 1998 （原著）

200. Sasano H, Suzuki T, Harada N. From Endocrinology to Incrinology. Endocrine Pathology. 9(1):9-20. 1998

（総説）

201. Shenton KC, Dowsett M, Lu Q, Brodie A, Sasano H, Sacks NP, Rowlands MG. Comparison of biochemical

aromatase activity with aromatase immunohistochemistry in human breast carcinomas. Breast Cancer

Research and Treatment 49 Suppl 1: S101-107; discussion. S109-119. 1998 （原著）

202. Takayama K, Zeitoun K, Gunby RT, Sasano H, Carr BR, Bulun SE. Treatment of severe postmenopausal

endometriosis with an aromatase inhibitor. Fertility&Sterility. 69(4):709-713. 1998 （原著）

203. Agarwal VR, Takayama K, Van Wyk JJ, Sasano H, Simpson ER, Bulun SE. Molecular basis of severe

gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. Journal of

Clinical Endocrinology and Metabolism. 83(5):1797-1800. 1998 （原著）

204. Sasano H, Harada N. Intratumoral aromatase in human breast, endometrial, and ovarian malignancies.

Endocrine Review. 19(5):593-607. 1998 （総説）

205. Sasano H, Yamaki H, Ohashi Y, Ohtsuki S, Nagura H. Proliferative fasciitis of the forearm: case study with

immunohistochemical, ultrastructural and DNA ploidy studies and a review of the literature. Pathology


206. Sasano H, Ohashi Y, Suzuki T, Nagura H. Vascularity in human adrenal cortex. Modern Pathology.

11(4):329-333. 1998 （原著）

207. Akahira J, Ito K, Kosuge S, Konno R, Sato S, Yajima A, Sasano H. Ovarian mixed germ cell tumor

composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old

woman: case study and literature review. Pathology International. 48(6):471-474. 1998 （症例）

208. Sasano H, Yamaki H, Nagura H. Detection of apoptotic cells in cytology specimens: an application of

TdT-mediated dUTP-biotin nick end labeling to cell smears. Diagnostic Cytopathology. 18(6):398-402. 1998 （原

著）

209. Suzuki T, Sasano H, Takaya R, Fukaya T, Yajima A, Nagura H. Cyclic changes of vasculature and vascular

phenotypes in normal human ovaries. Human Reproduction. 13(4):953-959. 1998 （原著）

210. Sasano H, Takashashi K, Satoh F, Nagura H, Harada N. Aromatase in the human central nervous system.

Clinical Endocrinology. 48(3):325-329. 1998 （原著）

211. Ishikura H, Sasano H. Histopathologic and immunohistochemical study of steroidogenic cells in the stroma

of ovarian tumors. International Jounral of Gynecological Pathology. 17(3):261-265. 1998 （原著）

212. Takahashi K, Totsune K, Sone M, Murakami O, Satoh F, Arihara Z, Sasano H, Iino K, Mouri T. Regional

distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain. Peptides.

19(4):643-647. 1998 （原著）

213. Sasano H, Suzuki T. Localization of steroidogenesis and steroid receptors in human corpus luteum.

Classification of human corpus luteum (CL) into estrogen-producing degenerating CL, and

nonsteroid-producing degenerating CL. Seminars in Reproductive Endocrinology. 15(4):345-351. 1997 （総説）

214. Sasano H, Murakami H. Immunolocalization of aromatase in human breast disorders using different

antibodies. Breast Cancer Res Treat. 49 Suppl 1:S79-84; discussion S109-119. 1998 （原著）

215. Igarashi T, Sasano H, Konno R, Sato S, Namiki T, Ohtani H, Nagura H, Yajima A. Malignant rhabdoid tumor

of the vulva: case study with cytological, immunohistochemical, utrastructural and DNA ploidy studies and a

review of the literature. Pathology International. 48(11):887-891. 1998 （症例）

216. Gell JS, Carr BR, Sasano H, Atkins B, Margraf L, Mason JI, Rainey WE. Adrenarche results from

development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis. Journal of Clinical


217. Suzuki T, Sasano H, Takaya R, Fukaya T, Yajima A, Date F, Nagura H. Leukocytes in normal- cycling

human ovaries: immunohistochemical distribution

and characterization. Human Reproduction. 13(8):2186-2191. 1998 （原著）

218. Sasano H. Glycogen and liver dysfunction in anorexia nervosa. Internal Medicine. 37(8):652. 1998 （解説）

219. Oikawa E, Iijima H, Suzuki T, Sasano H, Sato H, Kamataki A, Nagura H, Kang MJ, Fujino T, Suzuki H,

Yamamoto TT. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating

preadipocytes. Journal of Biochemistry. 124(3):679-685. 1998 （原著）

220. Koh J, Kubota T, Sasano H, Hashimoto M, Hosoda Y, Kitajima M. Stimulation of human tumor xenograft

growth by local estrogen biosynthesis in stromal cells. Anticancer Research. 18(4A):2375-2380. 1998 （原著）

221. Ito K, Sasano H, Yoshida Y, Sato S, Yajima A. Immunohistochemical study of cyclins D and E and cyclin

dependent kinase (cdk) 2 and 4 in human endometrial carcinoma. Anticancer Research. 18(3A):1661-1664.

1998 （原著）

222. Suzuki T, Sasano H, Suzuki S, Hirasawa G, Takeyama J, Muramatsu Y, Date F, Nagura H, Krozowski ZS.

11Beta-hydroxysteroid dehydrogenase type 2 in human lung: possible regulator of mineralocorticoid action.

Journal of Clinical Endocrinology and Metabolism. 83(11):4022-4025. 1998 （原著）

223. Yaguchi H, Tsutsumi K, Shimono K, Omura M, Sasano H, Nishikawa T. Involvement of high density

lipoprotein as substrate cholesterol for steroidogenesis by bovine adrenal fasciculo-reticularis cells. Life Science.

62(16):1387-1395. 1998 （原著）

224. Kim DH, Inagaki Y, Suzuki T, Ioka RX, Yoshioka SZ, Magoori K, Kang MJ, Cho Y, Nakano AZ, Liu Q, Fujino

T, Suzuki H, Sasano H, Yamamoto TT. A new low density lipoprotein receptor related protein, LRP5, is

expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. Journal of Biochemistry (Tokyo).

124(6):1072-1076. 1998 （原著）

225. Coire CI, Horvath E, Kovacs K, Smyth HS, Sasano H, Iino K, Feig DS. A composite silent corticotroph

pituitary adenoma with interspersed adrenocortical cells: case study. Neurosurgery. 42(3):650-654. 1998 （症

例）

226. Nakamura J, Imai E, Yoshihama M, Sasano H, Kubota T. Histoculture drug response assay, a possible

examination system for predicting the antitumor effect of aromatase inhibitors in patients with breast cancer.

Anticancer Research. 18(1A):125-128. 1998 （原著）

227. Sato S, Ito K, Jiko K, Konno R, Yajima A, Sasano H. Cytologic application of p53 overexpression using

immunocytochemistry and confocal laser scanning microscopy. Acta Cytologica. 42(2):342-345. 1998 （原著）

228. Onodera K, Sasano H, Ichinohasama R, Ooya K. Immunolocalization of aromatase in human minor

salivary glands of the lower lip with primary Sjogren's syndrome. Pathology International. 48(10):786-790. 1998

（原著）

229. Takeyama J, Sasano H, Suzuki T, Iinuma K, Nagura H, Andersson S. 17Beta-hydroxysteroid

dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental

development. Journal of Clinical Endocrinology and Metabolism. 83:3710-3715. 1998 （原著）

230. Hoshi T, Sasano H, Kato K, Yabuki N, Ohara S, Konno R, Asaki S, Toyota T,

Tateno H, Nagura H. Immunohistochemistry of Caspase3/CPP32 in human stomach and its correlation with cell

proliferation and apoptosis. Anticancer Research. 18(6A):4347-4353. 1998 （原著）

231. Yamazaki H, Abe Y, Katoh Y, Sawa N, Ohnishi Y, Tanaka Y, Sasano H, Oshika Y, Tokunaga T, Kijima H,

Tamaoki N, Nakamura M, Ueyama Y. Establishment of an adrenocortical carcinoma xenograft with

normotensive hyperaldosteronism in vivo. APMIS. 106:1056-1060. 1998 （原著）

232. Coulter CL, Smith RE, Stowasser M, Sasano H, Krozowski ZS, Gordon RD. Expression of 11betaHSD-2 in

human adrenal cortical carcinoma and adenoma. Endocrine Research. 24(3-4):875-876. 1998 （原著）

233. Nakazumi H, Sasano H, Iino K, Ohashi Y, Orikasa S. Expression of cell cycle inhibitor p27 and Ki-67 in

human adrenocortical neoplasms. Modern Pathology. 11(12):1165-1170. 1998 （原著）

234. Takahashi K, Sasano H, Fukushima K, Hirasawa G, Miura H, Sasaki I, Matsuno S, Krozowski ZS, Nagura

H. 11 beta-hydroxysteroid dehydrogenase type II in human colon: a new marker of fetal development and

differentiation in neoplasms. Anticancer Research. 18(5A):3381-3388. 1998 （原著）

235. Zeitoun K, Takayama K, Sasano H, Suzuki T, Moghrabi N, Andersson S, Johns A, Meng L, Putman M, Carr

B, Bulun SE. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression inendometriosis: failure to

metabolize 17beta-estradiol. Journal of Clinical Endocrinology and Metabolism. 83(12):4474-4480. 1998 （原著）

236. Yoshinaga K, Sasano H, Furukawa T, Yamakawa H, Yuki M, Sato S, Yajima A, Horii A. The PTEN, BAX,

and IGFIIR genes are mutated in endometrial atypical hyperplasia. Japanese Journal of Cancer Research.

89(10):985-990. 1998 （原著）

237. Funaki N, Sasano H, Shizawa S, Nio M, Iwami D, Ohi R, Nagura H. Apoptosis and cell proliferation in

biliary atresia. Journal of Pathology. 186(4):429-433. 1998 （原著）

238. Taniguchi R, Koshiyama H, Yamauchi M, Tanaka S, Inoue D, Sato Y, Sugawa A, Muramatsu Y, Sasano H.

A case of aldosterone-producing adenoma with severe postoperative. hyperkalemia. Tohoku Journal of

Experimental Medicine. 186(3):215-223. 1998 （症例）

239. Boman F, Vantyghem MC, Querleu D, Sasano H. Virilizing ovarian dermoid cyst with peripheral steroid

cells. A case study with immunohistochemical study of steroidogenesis. International Journal of Gynecological

Pathology. 18(2):174-177. 1999 （原著）

240. Hirasawa G, Sasano H, Suzuki T, Takeyama J, Muramatu Y, Fukushima K,

Hiwatashi N, Toyota T, Nagura H, Krozowski ZS. 11Beta-hydroxysteroid dehydrogenase type 2 and

mineralocorticoid receptor in human fetal development. Journal of Clinical Endocrinology and Metabolism.

84(4):1453-1458. 1999 （原著）

241. Morohashi K, Tsuboi-Asai H, Matsushita S, Suda M, Nakashima M, Sasano H, Hataba Y, Li CL, Fukata J,

Irie J, Watanabe T, Nagura H, Li E. Structural and functional abnormalities in the spleen of an mFtz-F1

gene-disrupted mouse. Blood. 93(5):1586-1594. 1999 （原著）

242. Sasano H, Suzuki T, Matsuzaki Y, Fukaya T, Endoh M, Nagura H, Kimura M. Messenger ribonucleic acid in

situ hybridization analysis of estrogen receptors alpha and beta in human breast carcinoma. Journal of Clinical


243. Harada N, Sasano H, Murakami H, Ohkuma T, Nagura H, Takagi Y. Localized expression of aromatase in

human vascular tissues. Circulation Research. 84(11):1285-1291. 1999 （原著）

244. Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T, Takahashi K, Suzuki H, Tezuka F, Yoshimi T,

Nagura H. Urocortin expression in the human central nervous system. Clinical Endocrinology (Oxf)

50(1):107-114. 1999 （原著）

245. Matsuzaki S, Fukaya T, Suzuki T, Murakami T, Sasano H, Yajima A. Oestrogen receptor alpha and beta

mRNA expression in human endometrium throughout the menstrual cycle. Molecular Human Reproduction.

5(6):559-564. 1999 （原著）

246. Konno R, Igarashi T, Okamoto S, Sato S, Moriya T, Sasano H, Yajima A. Apoptosis of human endometrium

mediated by perforin and granzyme B of NK cells and cytotoxic T lymphocytes. Tohoku Journal Experimental

Medicine. 187(2):149-155. 1999 （原著）

247. Imai T, Tobinaga J, Morita-Matsuyama T, Kikumori T, Sasano H, Seo H, Funahashi H. Virilizing

adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and

gene expression of corticotropin receptor. Surgery. 125(4):396-402. 1999 （原著）

248. Watanabe F, Oki Y, Ozawa M, Masuzawa M, Iwabuchi M, Yoshimi T, Nishiguchi T, Iino K, Sasano H.

Urocortin in human placenta and maternal plasma. Peptides. 20(2):205-209. 1999 （原著）

249. Krozowski Z, Li KX, Koyama K, Smith RE, Obeyesekere VR, Stein-Oakley A, Sasano H, Coulter C, Cole T,

Sheppard KE. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes. Journal of Steroid

Biochemistry Molecular Biology. 69(1-6):391-401. 1999 （原著）

250. Nakayama M, Takahashi K, Murakami O, Murakami H, Sasano H, Shirato K, Shibahara S. Adrenomedullin

in monocytes and macrophages: possible involvement of macrophage-derived adrenomedullin in atherogenesis.

Clinical Science (Lond). 97(2):247-251. 1999 （原著）

251. Kato K, Sasano H, Ohara S, Sekine H, Mochizuki S, Mune T, Yasuda K, Nagura H, Shimosegawa T, Toyota

T, Krozowski Z. Coexpression of mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenase 2 in

human gastric mucosa. Journal of Clinical Endocrinology and Metabolism. 84(7):2568-2573. 1999 （原著）

252. Fukushima K, Sasaki I, Sato S, Sasano H, Krozowski Z, Matsuno S. Induction of mineralocorticoid

receptor by sodium butyrate in small intestinal (IEC6) and colonic (T84) epithelial cell lines. Digestive Diseases

and Sciences. 44(8):1571-1578. 1999 （原著）

253. Ohashi Y, Sasano H, Yamaki H, Shizawa S, Kikuchi A, Shineha R, Akaishi T, Satomi S, Nagura H.

Topoisomerase II alpha expression in esophageal squamous cell carcinoma. Anticancer Research.

19(3A):1873-1880. 1999 （原著）

254. Ohashi Y, Sasano H, Yamaki H, Shizawa S, Shineha R, Akaishi T, Satomi S, Nagura H. Cell cycle inhibitory

protein p27 in esophageal squamous cell carcinoma. Anticancer Research. 19(3A):1843-1848. 1999 （原著）

255. Suzuki T, Kimura N, Shizawa S, Yabuki N, Yamaki T, Sasano H, Nagura H. Yolk sac tumor of the stomach

with an adenocarcinomatous component: A case study with immunohistochemical analysis. Pathology


256. Sasano H, Murakami H, Shizawa S, Satomi S, Nagura H, Harada N. Aromatase and sex steroid receptors

in human vena cava. Endocrine Journal. 46(2):233-242. 1999 （原著）

257. Shimono K, Tsutsumi K, Yaguchi H, Omura M, Sasano H, Nishikawa T. Lipoprotein lipase promoting agent,

NO-1886, modulates adrenal functions: species difference in effects of NO-1886 on steroidogenesis. Steroids.

64(7):453-459. 1999 （原著）

258. Midorikawa S, Hashimoto S, Kuriki M, Katoh K, Watanabe T, Sasano H, Nishikawa T. A patient with

preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and

contralateral adenoma. Endocrine Journal. 46(1):59-66. 1999 （症例）

259. Amari M, Suzuki A, Moriya T, Yoshinaga K, Amano G, Sasano H, Ohuchi N, Satomi S, Horii A. LOH

analyses of premalignant and malignant lesions of human breast: frequent LOH in 8p, 16q, and 17q in atypical

ductal hyperplasia. Oncology Report. 6(6):1277-1280. 1999 （原著）

260. Suzuki T, Sugino N, Fukaya T, Sugiyama S, Uda T, Takaya R, Yajima A, Sasano H. Superoxide dismutase

in normal cycling human ovaries: immunohistochemical localization and characterization. Fertility and Sterility.

72(4):720-726. 1999 （原著）

261. Coulter CL, Smith RE, Stowasser M, Sasano H, Krozowski ZS, Gordon RD. Expression of

11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD-2) in the developing human adrenal gland and

human adrenal cortical carcinoma and adenoma. Molecular Cell Endocrinology. 20(1-2):71-77. 1999 （原著）

262. Sasaki H, Sasano H, Ohi R, Imaizumi M, Shineha R, Nakamura M, Shibuya D, Hayashi Y.

Adenocarcinoma at the esophageal gastric junction arising in an 11-year-old girl. Pathology International.

49(12):1109-1113. 1999 （症例）

263. Takahashi K, Fukushima K, Sasano H, Sasaki I, Matsuno S, Krozowski ZS, Nagura H. Type II

11beta-hydroxysteroid dehydrogenase expression in human colonic epithelial cells of inflammatory bowel

disease. Digestive Diseases and Sciences. 44(12):2516-2522. 1999 （原著）

264. Hoshi T, Sasano H, Kato K, Ohara S, Shimosegawa T, Toyota T, Nagura H. Cell damage and proliferation

in human gastric mucosa infected by Helicobacter pylori--a comparison beforeand after H pylori eradication in

non-atrophic gastritis.

Human Pathology. 30(12):1412-1417. 1999 （原著）

265. Sasaki H, Suzuki T, Funaki N, Hoshi T, Iwabuchi M, Ohi R, Sasano H. Immunohistochemistry of DNA

fragmentation factor in human stomach and colon: its correlation to apoptosis. Anticancer Research.

19(6B):5277-5282. 1999 （原著）

266. Sasano H, Sato S, Ito K, Yajima A, Nakamura J, Yoshihama M, Ariga K, Anderson TJ, Miller WR. Effects of

aromatase inhibitors on the pathobiology of the human breast, endometrial and ovarian carcinoma. Endocrine

Related Cancer. 6(2):197-204. 1999 （原著）

267. Bulun SE, Zeitoun K, Takayama K, Noble L, Michael D, Simpson E, Johns A, Putman M, Sasano H.

Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. Endocrine Related

Cancer. 6(2):293-301. 1999 （原著）

268. Bulun SE, Zeitoun K, Sasano H, Simpson ER. Aromatase in aging women. Seminar of Reproductive

Endocrinology. 17(4):349-358. 1999 （総説）

269. Sasano H, Mizorogi A, Sato M, Nnakazumi H, Suzuki T. Superoxide dismutase in human adernal and its

disorders: A correlation with development and neoplastic changes. Endocrine Pathology. 10(4):325-333. 1999

（原著）

270. Albuquerque FC, Weiss MH, Kovacs K, Horvath E, Sasano H, Hinton DR. A functioning composite

'corticotroph' pituitary adenoma with interspersed adrenocortical cells. Pituitary. 1(3-4):279-284. 1999 （症例）

271. Takeyama J, Suzuki T, Hirasawa G, Muramatsu Y, Nagura H, Iinuma K, Nakamura J, Kimura KI, Yoshihama

M, Harada N, Andersson S, Sasano H. 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the

human fetus. Journal of Clinical Endocrinology & Metabolism. 85(1):410-416. 2000 （原著）

272. Moriya T, Sakamoto K, Sasano H, Kawanaka M, Sonoo H, Manabe T, Ito J. Immunohistochemical analysis

of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic

findings in 43 cases. Modern Pathology. 13:13-18. 2000 （原著）

273. Kimura K, Sasano H, Shimosegawa T, Mochizuki S, Nagura H, Toyota T. Ultrastructure of cells undergoing

apoptosis. Vitamin and Hormore. 58:257-266. 2000 （総説）

274. Suzuki T, Moriya T, Ariga N, Kaneko C, Kanazawa M, Sasano H. 17Beta-hydroxysteroid dehydrogenase

type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. British Journal of

Cancer. 82(3):518-523. 2000 （原著）

275. Speiser PW, Susin M, Sasano H, Bohrer S, Markowitz J. Ovarian hyperthecosis in the setting of portal

hypertension. Journal of Clinical Endocrinology & Metabolism. 85(2):873-877. 2000 （原著）

276. Hirasawa G, Takeyama J, Sasano H, Fukushima K, Suzuki T, Muramatu Y, Darnel AD, Kaneko C,

Hiwatashi N, Toyota T, Nagura H, Krozowski ZS. 11Beta-hydroxysteroid dehydrogenase type II and

mineralocorticoid receptor in human placenta. Journal of Clinical Endocrinology & Metabolism. 85(3):1306-1309.

2000 （原著）

277. Sone M, Takahashi K, Murakami O, Totsune K, Arihara Z, Satoh F, Sasano H, Ito H, Mouri T. Binding sites

for melanin-concentrating hormone in the human brain. Peptides. 21(2):245-250. 2000 （原著）

278. Suzuki S, Suzuki T, Tsubochi H, Koike K, Tateno H, Krozowski ZS, Sasano H. Expression of 11

beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor in primary lung carcinomas.

Anticancer Research. 20(1A):323-328. 2000 （原著）

279. Kaaijk EM, Sasano H, Suzuki T, Beek JF, van Der Veen F. Distribution of steroidogenic enzymes involved

in androgen synthesis in polycystic ovaries: an immunohistochemical study. Molecular Human Reproduction.

6:443-447. 2000 （原著）

280. Tashiro A, Sasano H, Nishikawa T, Yabuki N, Muramatsu Y, Coughtrie MW, Nagura H, Hongo M.

Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa. Journal of

Steroid Biochemistry Molecular Biology. 72:149-154. 2000 （原著）

281. Arai K, Muro H, Suzuki M, Oba N, Ito K, Sasano H. Adrenal rest tumor of the liver: A case study with

immunohistochemical investigation of steroidogenesis. Pathology International. 50(3):244-248. 2000 （症例）

282. Yoshimoto T, Naruse M, Ito Y, Naruse K, Ueda T, Tanabe A, Harada S, Nishikawa T, Sasano H, Obara T,

Demura H. Adrenocortical carcinoma manifesting pure primary aldosteronism: a case study and analysis of

steroidogenic enzymes. Journal of Endocrinological Investigation. 23(2):112-117. 2000 （症例）

283. Ariga N, Moriya T, Suzuki T, Kimura M, Ohuchi N, Satomi S, Sasano H. 17 beta-Hydroxysteroid

dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human

breast. Anticancer Research. 20(2B):1101-1108. 2000 （原著）

284. Iwabuchi M, Sasano H, Hiwatashi N, Masuda T, Shimosegawa T, Toyota T, Nagura H. Serrated adenoma:

a clinicopathological, DNA ploidy, and immunohistochemical study. Anticancer Research. 20(2B):1141-1147.

2000 （原著）

285. Tsubochi H, Suzuki T, Suzuki S, Ohashi Y, Ishibashi S, Moriya T, Fujimura S, Sasano H.

Immunohistochemical study of basaloid squamous cell carcinoma, adenoid cystic and mucoepidermoid

carcinoma in the upper aerodigestive tract. Anticancer Research. 20(2B):1205-1212. 2000 （原著）

286. Arihara Z, Takahashi K, Murakami O, Totsune K, Sone M, Satoh F, Ito S, Hayashi Y, Sasano H, Mouri T.

Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma. Peptides.

21(4):565-570. 2000 （原著）

287. Murakami M, Nakagawasai O, Fujii S, Hosono M, Hozumi S, Esashi A, Taniguchi R, Okamura T, Suzuki T,

Sasano H, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K. Antinociceptive effect of cilnidipine, a

novel N-type calcium channel antagonist. Brain Research. 868(1):123-127. 2000 （原著）

288. Matsuzaki S, Fukaya T, Uehara S, Murakami T, Sasano H, Yajima A. Characterization of messenger RNA

expression of estrogen receptor-alpha and -beta in patients with ovarian endometriosis. Fertility and Sterility.

73(6):1219-1225. 2000 （原著）

289. Matsuzaki S, Murakami T, Sato S, Moriya T, Sasano H, Yajima A. Endomyometriosis arising in the

uterosacral ligament: A case study including a literature review and immunohistochemical analysis. Pathology


290. Semba S, Moriya T, Youssef EM, Sasano H. An autopsy case of ovarian hyperstimulation syndrome with

massive pulmonary edema and pleural effusion. Pathology International. 50(7):549-552. 2000 （症例）

291. Sasano H, Suzuki T, Moriya T. Recent advances in surgical pathology of adrenal incidentaloma. Biomed &

Pharmacother. 54 Suppl 1:169s-174s. 2000 （総説）

292.Bulun SE, Zeitoun KM, Takayama K, Sasano H. Estrogen biosynthesis in endometriosis: molecular basis

and clinical relevance. Journal of Molecular Endocrinology. 25:35-42. 2000 （総説）

293. Iino K, Oki Y, Sasano H. A case of adrenocortical carcinoma associated with recurrence after laparoscopic

surgery. Clinical Endocrinology (Oxf). 53(2):243-248. 2000 （症例）

294. Yamanaka K, Iitaka M, Inaba M, Morita T, Sasano H, Katayama S. A case of renin-producing

adrenocortical cancer. Endocrine Journal. 47(2):119-125. 2000 （症例）

295. Suzuki T, Takahashi K, Darnel AD, MoriyaT, Murakami O, Narasaka T, Takeyama J, Sasano H. Chicken

ovalbumin upstream promoter transcription factor II in the human adrenal cortex and its disorders. Journal of

Clinical Endocrinology & Metabolism. 85(8):2752-2757. 2000 （原著）

296. Hasegawa T, Zhao L, Caron KM, Majdic G, Suzuki T, Shizawa S, Sasano H, Parker KL. Developmental

roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice. Molecular

Endocrinology. 14(9):1462-1471. 2000 （原著）

297.Suzuki T, Moriya T, Darnel AD, Takeyama J, Sasano H. Immunohistochemical distribution of chicken

ovalbumin upstream promoter transcription factor II in human tissues. Molecular and cellular Endocrinology.

164(1-2):69-75. 2000 （原著）

298. Bulun SE, Zeitoun KM, Takayama K, Sasano H. Molecular basis for treating endometriosis with aromatase

inhibitors. Human Reproduction Update. 6(5):413-418. 2000 （総説）

299. Kato M, Ioritani N, Suzuki T, Kambe M, Inaba Y, Watanabe R, Sasano H, Orikasa S. Mechanism of

anti-tumor effect of combination of bleomycin and shock waves. Japanese Journal of Cancer Research.

91(10):1065-1072. 2000 （原著）

300. Suzuki T, Sasano H, Andersson S, Mason JI. 3beta-hydroxysteroid dehydrogenase/delta5-->4-isomerase

activity associated with the human 17beta-hydroxysteroid dehydrogenase type 2 isoform. Journal of Clinical


301. Ohashi Y, Ishibashi S, Suzuki T, Shineha R, Moriya T, Satomi S, Sasano H. Significance of tumor

associated tissue eosinophilia and other inflammatory cell infiltrate in early esophageal squamous cell

carcinoma. Anticancer Research. 20(5A):3025-3030. 2000 （原著）

302.Takahashi K, Yoshinoya A, Arihara Z, Murakami O, Totsune K, Sone M, Sasano H, Shibahara S. Regional

distribution of immunoreactive prolactin-releasing peptide in the human brain. Peptides. 21:1551-1555. 2000

（原著）

303. Akahira J, Inoue T, Suzuki T, Ito K, Konno R, Sato S, Moriya T, Okamura K, Yajima A, Sasano H.

Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and

RT-PCR studies. British Journal of Cancer. 83(11):1488-1494. 2000 （原著）

304. Ariga N, Moriya T, Suzuki T, Kimura M, Ohuchi N, Sasano H. Retinoic Acid Receptor and Retinoid X

Receptor in Ductal Carcinoma in situ and Intraductal Proliferative Lesions of the Human Breast. Japanese

Journal of Cancer Research. 91(11):1169-1176. 2000 （原著）

305. Sasano H, Suzuki T, Takeyama J, Utsunomiya H, Ito K, Ariga N, Moriya T. 17-Beta-hydroxysteroid

dehydrogenase in human breast and endometrial carcinoma. a new development in intracrinology. Oncology. 59

Suppl. 1:5-12. 2000 （総説）

306. Utsunomiya H, Suzuki T, Harada N, Ito K, Matsuzaki S, Konno R, Sato S, Yajima A, Sasano H. Analysis of

estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic

findings in 45 cases. International Journal of Gynecological Pathology. 19(4):335-341. 2000 （原著）

307. Muramatsu Y, Fukushima K, Iino K, Totsune K, Takahashi K, Suzuki T, Hirasawa G, Takeyama J, Ito M,

Nose M, Tashiro A, Hongo M, Oki Y, Nagura H, Sasano H. Urocortin and corticotropin-releasing factor receptor

expression in the human colonic mucosa. Peptides. 21(12):1799-1809. 2000 （原著）

308. Suzuki T, Sasano H, Takeyama J, Kaneko C, Freije WA, Carr BR, Rainey WE. Developmental changes in

steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clinical

Endocrinology (Oxf) 53(6):739-747. 2000 （原著）

309. Narasaka T, Moriya T, Endoh M, Suzuki T, Shizawa S, Mizokami Y, Matsuoka T, Sasano H.

17Beta-hydroxysteroid dehydrogenase type 2 and dehydroepiandrosterone sulfotransferase in the human liver.


310. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V V, Haeseleer F, Palczewski K, Smith I I,

Komesaroff P, Krozowski Z. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Molecular and

cellular Endocrinology. 171(1-2):111-117. 2001 （原著）

311. Takamura T, Nagai Y, Taniguchi M, Yamashita H, Nakamura S, Ikeda T, Kobayashi K, Suzuki T, Sasano H.

Adrenocorticotropin-independent unilateral adrenocortical hyperplasia with Cushing's syndrome:

Immunohistochemical studies of steroidogenic enzymes, ultrastructural examination and a review of the

literature. Pathology International. 51(2):118-122. 2001 （症例）

312. Nagura H, Ohtani H, Sasano H, Matsumoto T. The immuno-inflammatory mechanism for tissue injury in

inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis. Roles of the mucosal

immune system. Digestion. 63 Suppl 1:12-21. 2001 （総説）

313. Honma W, Kamiyama Y, Yoshinari K, Sasano H, Shimada M, Nagata K, Yamazoe Y. Enzymatic

characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug metabolism and

disposition. 29(3):274-281. 2001 （原著）

314. Suzuki T, Sasano H, Kaneko C, Ogawa S, Darnel AD, Krozowski ZS. Immunohistochemical distribution of

11beta-hydroxysteroid dehydrogenase in human eye. Molecular and cellular Endocrinology. 173 (1-2):121-125.

2001 （原著）

315. Takahashi K, Totsune K, Murakami O, Sone M, Satoh F, Kitamuro T, Noshiro T, Hayashi Y, Sasano H,

Shibahara S. Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor

tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma. Journal of Clinical Endocrinology &

Metabolism. 86(1):369-374. 2001 （原著）

316. Muramatsu Y, Sugino N, Suzuki T, Totsune K, Takahashi K, Tashiro A, Hongo M, Oki Y, Sasano H.

Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries. Journal of


317. Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H. Retinoid receptors in human breast

carcinoma: possible modulators of in situ estrogen metabolism. Breast Cancer Research and Treatment.

65(1):31-40. 2001 （原著）

318. Suzuki S, Tsubochi H, Suzuki T, Darnel AD, Krozowski ZS, Sasano H, Kondo T. Modulation of

transalveolar fluid absorption by endogenous aldosterone in adult rats. Experimental Lung Research.

27(2):143-155. 2001 （原著）

319. Ariga N, Suzuki T, Moriya T, Kimura M, Inoue T, Ohuchi N, Sasano H. Progesterone receptor a and b

isoforms in the human breast and its disorders. Japanese Journal of Cancer Research. 92(3):302-308. 2001 （原

著）

320. Meng L, Zhou J, Sasano H, Suzuki T, Zeitoun KM, Bulun SE. Tumor necrosis factor alpha and interleukin

11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating

CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of

desmoplastic reaction. Cancer Research. 61(5):2250-2255. 2001 （原著）

321. Shimizu C, Kubo M, Takano K, Takano A, Kijima H, Saji H, Katsuyama I, Sasano H, Koike T. Interleukin-6

(IL-6) producing phaeochromocytoma: direct IL-6 suppression by non-steroidal anti-inflammatory drugs. Clinical

Endocrinology (Oxf). 54(3):405-410. 2001 （原著）

322. Narasaka T, Suzuki T, Moriya T, Sasano H. Temporal and spatial distribution of Corticosteroidogenic

Enzymes Immunoreactivity in developing human adrenal. Molecular and cellular Endocrinology.

174(1-2):111-120. 2001 （原著）

323. Suzuki T, Darnel AD, Akahira JI, Ariga N, Ogawa S, Kaneko C, Takeyama J, Moriya T, Sasano H.

5alpha-Reductases in human breast carcinoma: possible modulator of in situ androgenic actions. Journal of


324.Takeyama J, Suzuki T, Inoue S, Kaneko C, Nagura H, Harada N, Sasano H. Expression and Cellular

Localization of Estrogen Receptors alpha and beta in the Human Fetus. Journal of Clinical Endocrinology &

Metabolism. 86(5):2258-2262. 2001 （原著）

325. Uzuki M, Sasano H, Muramatsu Y, Totsune K, Takahashi K, Oki Y, Iino K, Sawai T. Urocortin in the synovial

tissue of patients with rheumatoid arthritis. Clinical Science (Lond). 100(6):577-589. 2001 （原著）

326. Murakami M, Suzuki T, Nakagawasai O, Murakami H, Murakami S, Esashi A, Taniguchi R, Yanagisawa T,

Tan-No K, Miyoshi I, Sasano H, Tadano T. Distribution of various calcium channel alpha (1) subunits in murine

DRG neurons and antinociceptive effect of omega-conotoxin SVIB in mice. Brain Research. 903(1-2):231-236.

2001 （原著）

327. Matsuzaki S, Murakami T, Uehara S, Canis M, Sasano H, Okamura K. Expression of estrogen receptor

alpha and beta in peritoneal and ovarian endometriosis. Fertility and Sterility. 75(6):1198-1205. 2001 （原著）

328. Yamaki H, Sasano H, Ohashi Y, Shizawa S, Shineha R, Satomi S, Nagura H. Alteration of X and Y

chromosomes in human esophageal squamous cell carcinoma. Anticancer Research. 21(2A):985-990. 2001

（原著）

329. Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H. Retinoid receptors in

the human endometrium and its disorders: a possible modulator of 17beta-hydroxysteroid dehydrogenase.

Journal of Clinical Endocrinolgy and Metabolism. 86(6):2721-2727. 2001 （原著）

330. Makino S, Oda S, Saka T, Yasukawa M, Komatsu F, Sasano H. A case of aldosterone-producing

adrenocortical adenoma associated with preclinical Cushing's syndrome and hypersecretion of parathyroid

hormone. Endocrine Journal. 48(1):103-111. 2001 （症例）

331. Cho YY, Kang MJ, Sone H, Suzuki T, Abe M, Igarashi M, Tokunaga T, Ogawa S, Takei YA, Miyazawa T,

Sasano H, Fujino T, Yamamoto TT. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and

reduced fertility in mice heterozygous for acyl-coa synthetase 4 deficiency. Biochemical and Biophysical

Research Communications. 284(4):993-997. 2001 （原著）

332. Utsunomiya H, Suzuki T, Kaneko C, Takeyama J, Nakamura J, Kimura K, Yoshihama M, Harada N, Ito K,

Konno R, Sato S, Okamura K, Sasano H. The analyses of 17beta-hydroxysteroid dehydrogenase isozymes in

human endometrial hyperplasia and carcinoma. Journal of Clinical Endocrinology and Metabolism.

86(7):3436-3443. 2001 （原著）

333. Moriya T, Suzuki T, Pilichowska M, Ariga N, Kimura N, Ouchi N, Nagura H,

Sasano H. Immunohistochemical expression of gonadotropin releasing hormone receptor in human breast

carcinoma. Pathology International. 51(5):333-337. 2001 （原著）

334. Ise T, Shimoda A, Takakuwa H, Kato T, Izumiya Y, Shimizu K, Suzuki T, Sasano H, Yokoyama H,

Kobayashi K. A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism.

Clinical Endocrinology (Oxf) 55(1):131-134. 2001 （原著）

335. Midorikawa S, Sanada H, Hashimoto S, Suzuki T, Watanabe T, Sasano H. Analysis of cortisol secretion in

hormonally inactive adrenocortical incidentalomas: study of in vitro steroid secretion and immunohistochemical

localization of steroidogenic enzymes. Endocrine Journal. 48(2):167-174. 2001 （原著）

336. Sasaki H, Nio M, Iwami D, Funaki N, Ohi R, Sasano H. Cytokeratin subtypes in biliary atresia:

Immunohistochemical study. Pathology International. 51(7):511-518. 2001 （原著）

337. Semba S, Yamakawa M, Sasano H. The cadherin-catenin superfamily in endocrine tumors. Endocrine

Pathology. 12(1):1-13. 2001 （総説）

338. Inoue T, Akahira J, Takeyama J, Suzuki T, Darnel AD, Kaneko C, Kurokawa Y, Satomi S, Sasano H. Spatial

and topological distribution of progesterone receptor A and B isoforms during human development. Molecular

and Cell Endocrinology. 182(1):83-89. 2001 （原著）

339. Sasano H, Matsuzaki S, Suzuki T. Estrogen receptor mRNA in situ hybridization using microprobe system.

Methods Molecular Biology. 176:317-325. 2001 （総説）

340. Kumamoto H, Sasano H, Taniguchi T, Suzuki T, Moriya T, Ichinohasama R. Chromogenic in situ

hybridization analysis of HER-2/neu status in breast carcinoma: application in screening of patients for

trastuzumab (Herceptin) therapy. Pathology International. 51(8):579-584. 2001 （原著）

341. Maeda S, Suzuki S, Moriya T, Suzuki T, Chida M, Suda H, Sakuma H, Kondo T, Sasano H. Isolated

unilateral absence of a pulmonary artery: influence of systemic circulation on alveolar capillary vessels.

Pathology International. 51(8):649-653. 2001 （症例）

342. Totsune K, Takahashi K, Arihara Z, Sone M, Satoh F, Ito S, Kimura Y, Sasano H, Murakami O. Role of

urotensin II in patients on dialysis. The Lancet. 358(9284):810-811. 2001 （原著）

343. Nakamura Y, Son Y, Kohno Y, Shimono D, Kuwamura N, Koshiyama H, Sasano H, Matsuda T. A case of

adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with possible adrenal

hypersensitivity to angiotensin II. Endocrine Journal. 15(1):57-61. 2001 （症例）

344. Akahira JI, Suzuki T, Ito K, Darnel AD, Moriya T, Sato S, Yaegashi N, Okamura K, Sasano H. Expression of

5alpha-reductases in human epithelial ovarian cancer: its correlation with androgen receptor status. Japanese

Journal of Cancer Research. 92(9):926-932. 2001 （原著）

345. Sano T, Hirasawa G, Takeyama J, Darnel AD, Suzuki T, Moriya T, Kato K, Sekine H, Ohara S,

Shimosegawa T, Nakamura J, Yoshihama M, Harada N, Sasano H. 17beta-Hydroxysteroid dehydrogenase

type 2 expression and enzyme activity in the human gastrointestinal tract. Clinical Science (Lond).101

(5):485-491. 2001 （原著）

346. Suzuki T, Inoue S, Kawabata W, Akahira J, Moriya T, Tsuchiya F, Ogawa S, Muramatsu M, Sasano H.

EBAG9/RCAS1 in human breast carcinoma: a possible factor in endocrine-immune interactions. British Journal

of Cancer. 85(11):1731-1737. 2001 （原著）

347. Kimura Y, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Darnel AD, Suzuki T, Ebina M, Nukiwa T,

Sasano H. Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart.

Journal of Clinical Endocrinology & Metabolism. 87(1):340-346. 2002 （原著）

348. Umemura S, Sakamoto G, Sasano H, Tsuda H, Akiyama F, Kurosumi M, Tokuda Y, Watanabe T, Toi M,

Hasegawa T, Osamura RY. Evaluation of HER2 status: for the treatment of metastatic breast cancers by

humanized anti-HER2 Monoclonal antibody (trastuzumab) (Pathological committee for optimal use of

trastuzumab). Breast Cancer. 8(4):316-320. 2001 （原著）

349. Yaegashi H, Moriya T, Soeda S, Yonemoto Y, Nagura H, Sasano H. Uterine angiomyolipoma: case report

and review of the literature. Pathology International. 51(11):896-901. 2001 （症例）

350. Sasaki H, Nio M, Iwami D, Funaki N, Sano N, Ohi R, Sasano H. E-cadherin, alpha-catenin and

beta-catenin in biliary atresia: correlation with apoptosis and cell cycle. Pathology International. 51(12):923-932.

2001 （原著）

351. Murakami H, Harada N, Sasano H. Aromatase in atherosclerotic lesions of human aorta. Journal of Steroid

Biochemistry and Molecular Biology. 79(1-5):67-74. 2001 （原著）

352. Ito A, Yamaguchi K, Onogawa T, Unno M, Suzuki T, Nishio T, Suzuki T, Sasano H, Abe T, Tamai M.

Distribution of Organic Anion-Transporting Polypeptide 2 (oatp2) and oatp3 in the Rat Retina. Investigative

Ophthalmology & Visual Science. 43(3):858-863. 2002 （原著）

353. Omura M, Sasano H, Fujiwara T, Yamaguchi K, Nishikawa T. Unique cases of unilateral

hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective

adrenal venous sampling. Metabolism. 51(3):350-355. 2002 （症例）

354. Maeda S, Suzuki S, Suzuki T, Endo M, Moriya T, Chida M, Kondo T, Sasano H. Analysis of intrapulmonary

vessels and epithelial-endothelial interactions in the human developing lung. Laboratory Investigation.

82(3):293-301. 2002 （原著）

355. Sasano H, Suzuki T, Moriya T. Discerning malignancy in resected adrenocortical neoplasms. Endocrine

Pathology. 12(4):397-406. 2001 （総説）

356 Iwabuchi M, Endoh M, Hiwatashi N, Kinouchi Y, Shimosegawa T, Masuda T, Moriya T, Sasano H.

Three-dimensional Reconstruction and Fractal Geometric Analysis of Serrated Adenoma. Japanese Journal of

Cancer Research. 93(3):259-266. 2002 （原著）

357. Noguchi K, Kato K, Moriya T, Suzuki T, Saito M, Kikuchi T, Yang J, Imatani A, Sekine H, Ohara S, Toyota T,

Shimosegawa T, Sasano H. Analysis of cell damage in Helicobacter pylori-associated gastritis. Pathology

International. 52(2):110-118. 2002 （原著）

358. Tsuda H, Sasano H, Akiyama F, Kurosumi M, Hasegawa T, Osamura RY, Sakamoto G. Evaluation of

interobserver agreement in scoring immunohistochemical results of HER-2/neu (c-erbB-2) expression detected

by HercepTest, Nichirei polyclonal antibody, CB11 and TAB250 in breast carcinoma. Pathology International.

52(2):126-134. 2002 （原著）

359. Yang S, Fang Z, Suzuki T, Sasano H, Zhou J, Gurates B, Tamura M, Ferrer K, Bulun S. Regulation of

Aromatase P450 Expression in Endometriotic and Endometrial Stromal Cells by CCAAT/Enhancer Binding

Proteins (C/EBPs): Decreased C/EBPbeta in Endometriosis Is Associated with Overexpression of Aromatase.

Journal of Clinical Endocrinology and Metabolism. 87(5):2336-2345. 2002 （原著）

360. Tamura M, Sebastian S, Yang S, Gurates B, Ferrer K, Sasano H, Okamura K, Bulun SE. Up-regulation of

cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant

endometrial epithelial cells: A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappaB. Journal

of Biochemistry. 277(29):26208-26216. 2002 （原著）

361. Ogawa Y, Matsumoto K, Maeda T, Tamai R, Suzuki T, Sasano H, Fernley RT. Characterization of Lacrimal

Gland Carbonic Anhydrase VI. Journal of Histochemistry & Cytochemistry. 50(6):821-828. 2002 （原著）

362. Yamahara K, Itoh H, Yamamoto A, Sasano H, Masatsugu K, Sawada N, Fukunaga Y, Sakaguchi S, Sone

M, Yurugi T, Nakao K. New diagnostic procedure for primary aldosteronism: adrenal venous sampling under

adrenocorticotropic hormone and angiotensin II receptor blocker--application to a case of bilateral multiple

adrenal microadenomas. Hypertension. 25(2):145-152. 2002 （原著）

363. Kageyama Y, Ishizaka K, Iwashina M, Sasano H, Kihara K. A case of ACTH-independent bilateral

macronodular adrenal hyperplasia successfully treated by subtotal resection of the adrenal glands: four-year

follow-up. Endocrine Journal. 49(2):227-229. 2002 （症例）

364. Ito K, Suzuki T, Akahira J, Moriya T, Kaneko C, Utsunomiya H, Yaegashi N, Okamura K, Sasano H.

Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders.

International Journal of Gynecological Cancer. 99(5):652-657. 2002 （原著）

365. Honma W, Shimada M, Sasano H, Ozawa S, Miyata M, Nagata K, Ikeda T, Yamazoe Y. Phenol

Sulfotransferase, ST1A3, as the Main Enzyme Catalyzing Sulfation of Troglitazone in Human Liver. Drug

metabolism and disposition. 30(8):944-952. 2002 （原著）

366. Takahashi K, Totsune K, Murakami O, Sone M, Noshiro T, Hayashi Y, Sasano H, Shibahara S. Expression

of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical

tumors, pheochromocytomas and neuroblastomas. Peptides. 23(6):1135-1140. 2002 （原著）

367. Rainey WE, Carr BR, Sasano H, Suzuki T, Mason JI. Dissecting human adrenal androgen production.

Trends in Endocrinology and Metabolism. 13(6):234-239. 2002 （総説）

368. Akahira J, Suzuki T, Ito K, Kaneko C, Darnel AD, Moriya T, Okamura K, Yaegashi N, Sasano H. Differential

expression of progesterone receptor isoforms a and B in the normal ovary, and in benign, borderline, and

malignant ovarian tumors. Japanese Journal of Cancer Research. 93(7):807-815. 2002 （原著）

369. Sasano H, Suziki T, Irle J, Kawal K, Alba M, McNicol AM, Takami H. Adrenal cortical diseases: international

case conference. Endocrine Pathology. 13(2):141-148. 2002 （総説）

370. Gurates B, Sebastian S, Yang S, Zhou J, Tamura M, Fang Z, Suzuki T, Sasano H, Bulun SE. WT1 and

DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. Journal of


371. Yamakita N, Murai T, Miyamoto K, Matsunami H, Ikeda T, Sasano H, Mune T, Yasuda K. Variant of

pre-clinical Cushing's syndrome: hypertension and hypokalemia associated with normoreninemic

normoaldosteronism. Hypertension Research. 25(4):623-630. 2002 （原著）

372. Inoue T, Akahira JI, Suzuki T, Darnel AD, Kaneko C, Takahashi K, Hatori M, Shirane R, Kumabe T,

Kurokawa Y, Satomi S, Sasano H. Progesterone Production and Actions in the Human Central Nervous System

and Neurogenic Tumors. Journal of Clinical Endocrinology and Metabolism. 87(11):5325-5331. 2002 （原著）

373. Kimura Y, Suzuki T, Kaneko C, Darnel AD, Moriya T, Suzuki S, Handa M, Ebina M, Nukiwa T, Sasano H.

Retinoid receptors in the developing human lung. Clinical Science (Lond). 103(6):613-621. 2002 （原著）

374. Suzuki T, Moriya T, Ishida T, Kimura M, Ohuchi N, Sasano H. In situ Production of Estrogens in Human

Breast Carcinoma. Breast Cancer. 9(4):296-302. 2002 （原著）

375. Miki Y, Nakata T, Suzuki T, Darnel AD, Moriya T, Kaneko C, Hidaka K, Shiotsu Y, Kusaka H, Sasano H.

Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. Journal

of Clinical Endocrinology and Metabolism. 87(12):5760-5768. 2002 （原著）

376. Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T,

Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT. Expression cloning and characterization of a novel

GPI-anchored HDL binding protein, GPI-HBP1. The Journal of biological chemistry. 278(9):7344-7349. 2002

（原著）

377. Suzuki T, Nakamura Y, Moriya T, Sasano H. Effects of steroid hormones on vascular functions. Microscopy

research and technique. 60(1):76-84. 2003 （総説）

378. Suzuki T, Murry BA, Darnel AD, Sasano H. Progesterone metabolism in human leukemic monoblast U937

cells. Endocrine Journal. 49(5):539-546. 2002 （原著）

379. Tsubochi H, Suzuki S, Kubo H, Ueno T, Yoshimura T, Suzuki T, Sasano H, Kondo T. Early Changes in

Alveolar Fluid Clearance by Nitric Oxide after Endotoxin Instillation in Rats. American journal of respiratory and

critical care medicine. 167(2):205-210. 2003 （原著）

380. Mune T, Morita H, Suzuki T, Takahashi Y, Isomura Y, Tanahashi T, Daido H, Yamakita N, Deguchi T, Sasano

H, Yasuda K, White PC. Role of local 11beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) expression in

determining the phenotype of adrenal adenomas. Endocrine research. 28(4):751-752. 2002 （原著）

381. Izumi M, Serizawa H, Iwaya K, Takeda K, Sasano H, Mukai K. A case of myxoid adrenocortical carcinoma

with extensive lipomatous metaplasia. Archives of Pathology & Laboratory Medicine. 127(2):227-230. 2003 （症

例）

382. Suzuki S, Koyama K, Darnel A, Ishibashi H, Kobayashi S, Kubo H, Suzuki T, Sasano H, Krozowski ZS.

Dexamethasone upregulates 11beta-hydroxysteroid dehydrogenase type 2 in BEAS-2B cells. American journal

of respiratory and critical care medicine. 167(9):1244-1249. 2003 （原著）

383. Mune T, Morita H, Suzuki T, Takahashi Y, Isomura Y, Tanahashi T, Daido H, Yamakita N, Deguchi T, Sasano

H, White PC, Yasuda K. Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining

the phenotype of adrenal adenomas. Journal of Clinical Endocrinology and Metabolism. 88(2):864-870. 2003

（原著）

384. Sato Y, Terada Y, Utsunomiya H, Koyanagi Y, Ito M, Miyoshi I, Suzuki T, Sasano H, Murakami T, Yaegashi

N, Okamura K. Immunohistochemical localization of steroidogenic enzymes in human follicle following

xenotransplantation of the human ovarian cortex into NOD-SCID mice. Molecular reproduction and

development. 65(1):67-72. 2003 （原著）

385 Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C,

Krozowski Z. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.

Endocrinology. 144(5):2084-2091. 2003 （原著）

386. Ishibashi H, Suzuki T, Suzuki S, Moriya T, Kaneko C, Takizawa T, Sunamori M, Handa M, Kondo T, Sasano

H. Sex steroid hormone receptors in human thymoma. Journal of Clinical Endocrinology and Metabolism.

88(5):2309-2317. 2003 （原著）

387. Kai K, Satoh N, Watanabe A, Shiraiwa K, Sasano H, Furuhama K. Case study of rat true hermaphroditism:

colocalization of oocytes and granulosa and sertoli cells in the germinal cord. Toxicologic pathology.

31(3):290-294. 2003 （症例）

388. Kawabata W, Suzuki T, Moriya T, Fujimori K, Naganuma H, Inoue S, Kinouchi Y, Kameyama K, Takami H,

Shimosegawa T, Sasano H. Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase

type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions. Modern Pathology.

16(5):437-444. 2003 （原著）

389. Utsunomiya H, Suzuki T, Ito K, Moriya T, Konno R, Sato S, Yaegashi N, Okamura K, Sasano H. The

correlation between the response to progestogen treatment and the expression of progesterone receptor B and

17beta-hydroxysteroid dehydrogenase type 2 in human endometrial carcinoma. Clinical endocrinology.

58(6):696-703. 2003 （原著）

390. Suzuki T, Nakata T, Miki Y, Kaneko C, Moriya T, Ishida T, Akinaga S, Hirakawa H, Kimura M, Sasano H.

Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Research.

63(11):2762-2770. 2003 （原著）

391. Fukushima A, Okada Y, Tanikawa T, Kawahara C, Misawa H, Kanda K, Morita E, Sasano H, Tanaka Y.

Virilizing adrenocortical adenoma with Cushing's syndrome, thyroid papillary carcinoma and hypergastrinemia

in a middle-aged woman. Endocrine Journal. 50(2):179-187. 2003 （原著）

392. Ishiguro H, Kato K, Kishimoto T, Nagai Y, Takahashi T, Sasano H, Ishikura H. Expression of steroidogenic

enzymes by luteinizing cells in the ovarian-type stroma of a mucin-producing cystic tumour of the pancreas.

Histopathology. 43(1):97-98. 2003 （原著）

393. Yang M, Moriya T, Oguma M, De La Cruz C, Endoh M, Ishida T, Hirakawa H, Orita Y, Ohuchi N, Sasano H.

Microinvasive ductal carcinoma (T1mic) of the breast. The clinicopathological profile and immunohistochemical

features of 28 cases. Pathology International. 53(7):422-428. 2003 （原著）

394. Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H. Immunolocalization of nuclear transcription

factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding

protein/steroidogenic factor-1 immunolocalization during the menstrual cycle. Journal of Clinical Endocrinology

and Metabolism. 88(7):3415-3420. 2003 （原著）

395. Kawamura M, Owada M, Ino J, Sugawara T, Nakano T, Mochizuki I, Sakuma T, Segawa T, Motegi I,

Sasano H. Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal

18-hydroxy-11-deoxycorticosterone production bilaterally. Internal medicine. 42(6):507-512. 2003 （原著）

396. Mikami Y, Manabe T, Epstein JI, Shiraishi T, Furusato M, Tsuzuki T, Matsuno Y, Sasano H. Accuracy of

gleason grading by practicing pathologists and the impact of education on improving agreement. Human

pathology. 34(7):658-665. 2003 （原著）

397. Ogawa T, Shiga K, Tateda M, Saijo S, Suzuki T, Sasano H, Miyagi T, Kobayashi T. Protein expression of

p53 and Bcl-2 has a strong correlation with radiation resistance of laryngeal squamous cell carcinoma but does

not predict the radiation failure before treatment. Oncology Report. 10(5):1461-1466. 2003 （原著）

398. Nakabayashi M, Suzuki T, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Date F, Takeyama J, Darnel

AD, Moriya T, Sasano H. Orexin-A expression in human peripheral tissues. Molecular and Cellular

Endocrinology. 205(1-2):43-50. 2003 （原著）

399. Kimura Y, Suzuki T, Kaneko C, Darnel A, Akahira J, Ebina M, Nukiwa T, Sasano H. Expression of androgen

receptor, and 5a-reductase types 1 and 2 in early gestation fetal lung: A possible corelation with branching

morphogenesis. Clinical science (Lond). 105(6):709-713. 2003 （原著）

400. Murakami M, Yamamura H, Suzuki T, Kang MG, Ohya S, Murakami A, Miyoshi I, Sasano H, Muraki K,

Hano T, Kasai N, Nakayama S, Campbell KP, Flockerzi V, Imaizumi Y, Yanagisawa T, Iijima T. Modified

cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta 3 subunit. The

Journal of biological chemistry. 278(44):43261-43267. 2003 （原著）

401. Adachi J, Hirai Y, Terui K, Nakano T, Fukuda Y, Suda T, Sasano H. A report of 7 cases of adrenal tumors

secreting both cortisol and aldosterone. Internal medicine. 42(8):714-718. 2003 （原著）

402. Konishi A, Tazawa C, Miki Y, Darnel AD, Suzuki T, Ohta Y, Suzuki T, Tabayashi K, Sasano H. The possible

roles of mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the

spontaneously hypertensive rat. Journal of Steroid Biochemistry and Molecular Biology. 85(2-5):439-442. 2003

（原著）

403. Mori T, Murakami Y, Nishiki M, Koshimura K, Sasano H, Kato Y. Expression of hypothalamic

corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: a report of an autopsied

case. Journal of Endocrinological Investigation. 26(6):556-559. 2003 （原著）

404. Murakami M, Miyoshi I, Suzuki T, Sasano H, Iijima T. Structures of the Murine Genes for the beta1- and

beta4-Subunits of the Voltage-Dependent Calcium Channel. Journal of molecular neuroscience. 21(1):13-22.

2003 （原著）

405. Nakamura Y, Miki Y, Suzuki T, Nakata T, Darnel AD, Moriya T, Tazawa C, Saito H, Ishibashi T, Takahashi S,

Yamada S, Sasano H. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta.

American Journal of Pathology. 163(4):1329-1339. 2003 （原著）

406. Koshiyama H, Fujisawa T, Kuwamura N, Nakamura Y, Kanamori H, Oida E, Hara A, Suzuki T, Sasano H. A

case of normoreninemic aldosterone-producing adenoma associated with chronic renal failure: case study and

literature review. Endocrine. 21(3):221-226. 2003 （原著）

407. Yang J, Kato K, Noguchi K, Dairaku N, Koike T, Iijima K, Imatani A, Sekine H, Ohara S, Sasano H,

Shimosegawa T. Tochu (Eucommia ulmoides) leaf extract prevents ammonia and vitamin C deficiency induced

gastric mucosal injury. Life Science. 73(25):3245-3256. 2003 （原著）

408. Sugawara A, Takeuchi K, Suzuki T, Itoi K, Sasano H, Ito S. A case of aldosterone-producing adrenocortical

adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal

gland. Hypertension Research. 26(8):663-668. 2003 （原著）

409. Ishizuka M, Hatori M, Suzuki T, Miki Y, Darnel AD, Tazawa C, Sawai T, Uzuki M, Tanaka Y, Kokubun S,

Sasano H. Sex steroid receptors in rheumatoid arthritis. Clinical science(Lond). 106(3):293-300. 2004 （原著）

410. Ito A, Yamaguchi K, Tomita H, Suzuki T, Onogawa T, Sato T, Mizutamari H, Mikkaichi T, Nishio T, Suzuki T,

Unno M, Sasano H, Abe T, Tamai M. Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the

rat eye. Investigative ophthalmology & visual science. 44(11):4877-4884. 2003 （原著）

411. Suzuki S, Tsubochi H, Darnel A, Suzuki T, Sasano H, Krozowski ZS, Kondo T. Expression of 11

beta-hydroxysteroid dehydrogenase type 1 in alveolar epithelial cells in rats. Endocrine Journal. 50(4):445-451.

2003 （原著）

412. Ishibashi H, Moriya T, Matsuda Y, Sado T, Hoshikawa Y, Chida M, Sato M, Sasano H, Kondo T. Pulmonary

mucinous cystadenocarcinoma: report of a case and review of the literature. The Annals of thoracic surgery.

76(5):1738-1740. 2003 （原著）

413. Abd-Elaziz M, Akahira J, Moriya T, Suzuki T, Yaegashi N, Sasano H. Nuclear receptor DAX-1 in human

common epithelial ovarian carcinoma: An independent prognostic factor of clinical outcome. Cancer Science.

94(11):980-985. 2003 （原著）

414. Sasano H, Dowsett M, Pasqualini JR. Preface. Journal of Steroid Biochemistry and Molecular Biology.

86(3-5):217. 2003 （総説）

415. Bulun SE, Sebastian S, Takayama K, Suzuki T, Sasano H, Shozu M. The human CYP19 (aromatase P450)

gene: update on physiologic roles and genomic organization of promoters. Journal of Steroid Biochemistry and

Molecular Biology. 86(3-5):219-224. 2003 （原著）

416. Sasano H, Edwards DP, Anderson TJ, Silverberg SG, Evans DB, Santen RJ, Ramage P, Simpson ER,

Bhatnagar AS, Miller WR. Validation of new aromatase monoclonal antibodies for immunohistochemistry:

progress report. Journal of Steroid Biochemistry and Molecular Biology. 86(3-5):239-244. 2003 （原著）

417. Suzuki T, Miki Y, Nakata T, Shiotsu Y, Akinaga S, Inoue K, Ishida T, Kimura M, Moriya T, Sasano H. Steroid

sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma. Journal of Steroid

Biochemistry and Molecular Biology. 86(3-5):449-454. 2003 （原著）

418. Nakata T, Takashima S, Shiotsu Y, Murakata C, Ishida H, Akinaga S, Li PK, Sasano H, Suzuki T, Saeki T.

Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients. Journal of

Steroid Biochemistry and Molecular Biologyl. 86(3-5):455-460. 2003 （原著）

419. Suzuki S, Tsubochi H, Ishibashi H, Suzuki T, Kondo T, Sasano H. Increased expression of 11

beta-hydroxysteroid dehydrogenase type 2 in the lungs of patients with acute respiratory distress syndrome.

Pathogy International. 53(11):751-756. 2003 （原著）

420. Suzuki T, Moriya T, Ishida T, Ohuchi N, Sasano H. Intracrine mechanism of estrogen synthesis in breast

cancer. Biomedicine & Pharmacotherapy. 57(10):460-462. 2003 （総説）

421.Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE. The Orphan Nuclear Receptors NURR1 and

NGFIB Regulate Adrenal Aldosterone Production. Molecular Endocrinology. 18(2):279-290. 2004 （原著）

422. Murakami M, Aoyama M, Suzuki T, Sasano H, Nakayama S, Iijima T. Genetic characterization of a new

splice variant of the beta2 subunit of the voltage-dependent calcium channel. Molecular and Cellular

Biochemistry. 254(1-2):217-225. 2003 （原著）

423. Sakamoto K, Monobe Y, Kouno M, Moriya T, Sasano H. Hepatoid adenocarcinoma of the gallbladder:

Case study and review of the literature. Pathogy International. 54(1):52-56. 2004 （原著）

424. Amari M, Moriya T, Ishida T, Harada Y, Ohnuki K, Takeda M, Sasano H, Horii A, Ohuchi N. Loss of

Heterozygosity Analyses of Asynchronous Lesions of Ductal Carcinoma in situ and Invasive Ductal Carcinoma

of the Human Breast. Japanese Journal of Clinical Oncology. 33(11):556-62. 2003 （原著）

425. De La Cruz C, Moriya T, Endoh M, Watanabe M, Takeyama J, Yang M, Oguma M, Sakamoto K, Suzuki T,

Hirakawa H, Orita Y, Ohuchi N, Sasano H. Invasive micropapillary carcinoma of the breast: Clinicopathological

and immunohistochemical study. Pathogy International. 54(2):90-96. 2004 （原著）

426. Tatsuno I, Uchida D, Tanaka T, Koide H, Shigeta A, Ichikawa T, Sasano H, Saito Y. Vasopressin

responsiveness of subclinical Cushing's syndrome due to ACTH-independent macronodular adrenocortical

hyperplasia. Clinical Endocrinology (Oxf). 60(2):192-200. 2004 （原著）

427. Ebina M, Shimizukawa M, Shibata N, Kimura Y, Suzuki T, Endo M, Sasano H, Kondo T, Nukiwa T.

Heterogeneous Increase of CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis. American

Journal of Respiratory and Critical Care Medicine. 169(11):1203-1208. 2004 （原著）

428. Armand R, Cappola AR, Horenstein RB, Drachenberg CB, Sasano H, Papadimitriou JC. Adrenal cortical

adenoma with excess black pigment deposition, combined with myelolipoma and clinical Cushing's syndrome.

International Journal of Surgical Pathology. 12(1):57-61. 2004 （原著）

.

429. Mikami Y, Maehata K, Fujiwara K, Sasano H. Squamous cell carcinoma of the uterine cervix in association

with stage 0 chronic lymphocytic leukemia/small lymphocytic lymphoma. Gynecologic Oncology. 92(3):974-977.

2004 （原著）

430. Inoue T, Suzuki T, Nakagawa K, Kurokawa Y, Satomi S, Moriya T, Sasano N, Sasano H.

Immunohistopathological and molecular genetic features of a case in which gastrointestinal stromal tumor

recurred five times. Pathology International. 54(3):196-200. 2004 （原著）

431. Inoue T, Sasano H. Possible effects of progesterone on human central nervous system and neurogenic

tumors. Journal of Endocrinological Investigation. 27(1):76-79. 2004 （総説）

432. Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S.

Expression of urocortin III/stresscopin in human heart and kidney. Journal of Clinical Endocrinology and

Metabolism. 89(4):1897-1903. 2004 （原著）

433. Bulun SE, Takayama K, Suzuki T, Sasano H, Yilmaz B, Sebastian S. Organization of the human aromatase

p450 (CYP19) gene. Seminars in Reproductive Medicine. 22(1):5-9. 2004 （総説）

434. Akahira J, Sugihashi Y, Suzuki T, Ito K, Niikura H, Moriya T, Nitta M, Okamura H, Inoue S, Sasano H,

Okamura K, Yaegashi N. Decreased expression of 14-3-3 sigma is associated with advanced disease in human

epithelial ovarian cancer: its correlation with aberrant DNA methylation. Clinical Cancer Research.

10(8):2687-2693. 2004 （原著）

435. Shimada N, Suzuki T, Inoue S, Kato K, Imatani A, Sekine H, Ohara S, Shimosegawa T, Sasano H.

Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. Molecular and Cellular


436. Mikami Y, Kiyokawa T, Hata S, Fujiwara K, Moriya T, Sasano H, Manabe T, Akahira JI, Ito K, Tase T,

Yaegashi N, Sato I, Tateno H, Naganuma H. Gastrointestinal immunophenotype in adenocarcinomas of the

uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular

hyperplasia/pyloric gland metaplasia and 'adenoma malignum'. Modern Pathology. 17:962-972. 2004 （原著）

437. Nakamura Y, Suzuki T, Miki Y, Tazawa C, Senzaki K, Moriya T, Saito H, Ishibashi T, Takahashi S, Yamada S,

Sasano H. Estrogen receptors in atherosclerotic human aorta: inhibition of human vascular smooth muscle cell

proliferation by estrogens. Molecular and Cellular Endocrinology. 219(1-2):17-26. 2004 （原著）

438. Akahira JI, Aoki M, Suzuki T, Moriya T, Niikura H, Ito K, Inoue S, Okamura K, Sasano H, Yaegashi N.

Expression of EBAG9/RCAS1 is associated with advanced disease in human epithelial ovarian cancer. British

Journal of Cancer. 90(11):2197-2202. 2004 （原著）

439. Urano T, Takahashi S, Suzuki T, Fujimura T, Fujita M, Kumagai J, Horie-Inoue K, Sasano H, Kitamura T,

Ouchi Y, Inoue S. 14-3-3sigma is down-regulated in human prostate cancer. Biochemical and Biophysical

Research Commun. 319(3):795-800. 2004 （原著）

440. Bassett MH, Suzuki T, Sasano H, De Vries CJ, Jimenez PT, Carr BR, Rainey WE. The orphan nuclear

receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase: Implications for the control of

adrenal functional zonation. The Journal of Biological Chemistry. 279(36):37622-37630. 2004 （原著）

441. Tokunagaa H, Miyamura N, Sasaki K, Yoshizato K, Itasaka M, Nakamaru K, Suefuji M, Kawashima J,

Matsumoto K, Sasano H, Araki E. Preclinical Cushing's Syndrome Resulting from Black Adrenal Adenoma. A

Case report. Hormone Research. 62(2):60-66. 2004 （原著）

442. Suzuki T, Miki Y, Moriya T, Shimada N, Ishida T, Hirakawa H, Ohuchi N, Sasano H. Estrogen-Related

Receptor {alpha} in Human Breast Carcinoma as a Potent Prognostic Factor. Cancer Research.

64(13):4670-4676. 2004 （原著）

443. Deb S, Amin S, Imir AG, Yilmaz MB, Suzuki T, Sasano H, Bulun SE. Estrogen regulates expression of

tumor necrosis factor receptors in breast adipose fibroblasts. Journal of Clinical Endocrinology and Metabolism.

89(8):4018-4024. 2004 （原著）

444. Lu L, Suzuki T, Yoshikawa Y, Murakami O, Miki Y, Moriya T, Bassett MH, Rainey WE, Hayashi Y, Sasano H.

Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. Journal

of Clinical Endocrinology and Metabolism. 89(8):4113-4118. 2004 （原著）

445. Kato M, Suzuki T, Suzuki Y, Terasawa Y, Sasano H, Arai Y. Natural history of small renal cell carcinoma:

evaluation of growth rate, histological grade, cell proliferation and apoptosis. The Journal of Urology.

172(3):863-866. 2004 （原著）

446. Utsunomiya H, Ito K, Suzuki T, Kitamura T, Kaneko C, Nakata T, Niikura H, Okamura K, Yaegashi N,

Sasano H. Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clinical Cancer

Research. 10(17):5850-5856. 2004 （原著）

447. Saner KJ, Suzuki T, Sasano H, Pizzey J, Ho C, Strauss JF 3rd, Carr BR, Rainey WE. Steroid

sulfotransferase (SULT2A1) gene transcription is regulated by steroidogenic factor 1 (SF1) and GATA-6 in the

human adrenal. Molecular Endocrinology. 19(2):184-197. 2004 （原著）

448. Murakami M, Nakagawasai O, Suzuki T, Mobarakeh II, Sakurada Y, Murata A, Yamadera F, Miyoshi I, Yanai

K, Tan-No K, Sasano H, Tadano T, Iijima T. Antinociceptive effect of different types of calcium channel inhibitors

and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain

Research. 1024(1-2):122-129. 2004 （原著）

449. Oki Y, Sasano H. Localization and physiological roles of urocortin. Peptides. 25(10):1745-1749. 2004 （総

説）

450. Saruta M, Takahashi K, Suzuki T, Torii A, Kawakami M, Sasano H. Urocortin 1 in colonic mucosa in patients

with ulcerative colitis. Journal of Clinical Endocrinology and Metabolism. 89(11):5352-5361. 2004 （原著）

451. Moriya T, Usami S, Tada H, Kasajima A, Ishida K, Kariya Y, Ohuchi N, Sasano H. Pathological evaluation

of sentinel lymph nodes for breast cancer. Asian Journal of Surgery. 27(4):256-261. 2004 （総説）

452. Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa

T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H. E4F1, a Novel

Estrogen-Responsive Gene in Possible Atheroprotection, Revealed by Microarray Analysis. American Journal

of Pathology. 165(6):2019-2031. 2004 （原著）

453. Imai J, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Uno K, Hasegawa Y, Gao J, Ishihara H, Sasano H,

Mizuguchi H, Asano T, Oka Y. Constitutively active PDX1 induced efficient insulin production in adult murine liver.

Biochemical and Biophysical Research Communications. 326(2):402-409. 2005 （原著）

454. Moriya T, Hirakawa H, Suzuki T, Sasano H, Ohuchi N. Ductal Carcinoma in situ and Related Lesions of the

Breast: Recent Advances in Pathology Practice. Breast Cancer. 11(4):325-333. 2004 （原著）

455. Imai J, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Uno K, Hasegawa Y, Gao J, Ishihara H, Sasano H,

Mizuguchi H, Asano T, Oka Y. Constitutively active PDX1 induced efficient insulin production in adult murine liver.

Biochemical and Biophysical Research Communications. 326(2):402-409. 2005 （原著）

456. Sato S, Fukushima K, Naito H, Funayama Y, Suzuki T, Sasano H, Krozowski Z, Shibata C, Sasaki I.

Induction of 11beta-hydroxysteroid dehydrogenase type 2 and hyperaldosteronism are essential for enhanced

sodium absorption after total colectomy in rats. Surgery. 137(1):75-84. 2005 （原著）

457. Mikami Y, Kiyokawa T, Moriya T, Sasano H. Immunophenotypic alteration of the stromal component in

minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study

using oestrogen receptor and alpha-smooth muscle actin double immunostaining. Histopathology.

46(2):130-136. 2005 （原著）

458. Zhou J, Suzuki T, Kovacic A, Saito R, Miki Y, Ishida T, Moriya T, Simpson ER, Sasano H, Clyne CD.

Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer. Cancer

Research. 65(2):657-663. 2005 （原著）

459. Miki Y, Suzuki T, Tazawa C, Blumberg B, Sasano H. Steroid and xenobiotic receptor (SXR), cytochrome

P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Molecular and Cellular


460. Cunat S, Rabenoelina F, Daures JP, Katsaros D, Sasano H, Miller WR, Maudelonde T, Pujol P. Aromatase

expression in ovarian epithelial cancers. Journal of Steroid Biochemistry and Molecular Biology. 93(1):15-24.

2005 （原著）

461. Nakamura Y, Suzuki T, Inoue T, Tazawa C, Moriya T, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano

H. 3beta-Hydroxysteroid dehydrogenase in human aorta. Endocrine Journal. 52(1):111-115. 2005 （原著）

462. Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, Sasano H. Analysis of gene expression induced

by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Letters.

220(2):197-210. 2005 （原著）

463. Abd-Elaziz M, Moriya T, Akahira J, Nakamura Y, Suzuki T, Sasano H. Immunolocalization of nuclear

transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with

StAR and steroidogenic enzymes in epithelial ovarian carcinoma. International Journal of Gynecological

Pathology. 24(2):153-63. 2005 （原著）

464. Nakamura Y, Suzuki T, Nakabayashi M, Endoh M, Sakamoto K, Mikami Y, Moriya T, Ito A, Takahashi S,

Yamada S, Arai Y, Sasano H. In situ androgen producing enzymes in human prostate cancer. Endocrine

Related Cancer. 12(1):101-107. 2005 （原著）

465. Okamoto S, Ito K, Sasano H, Moriya T, Niikura H, Terada Y, Sato S, Okamura K, Yaegashi N. Ber-EP4 and

anti-calretinin antibodies: a useful combination for differential diagnosis of various histological types of ovarian

cancer cells and mesothelial cells. Tohoku Journal of Experimental Medicine. 206(1):31-40. 2005 （原著）

466. Abd-Elaziz M, Moriya T, Akahira J, Suzuki T, Sasano H. StAR and progesterone producing enzymes

(3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human

epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies. Cancer Science. 96(4):232-239.

2005 （原著）

467. Nakamura Y, Suzuki T, Inoue T, Tazawa C, Ono K, Moriya T, Saito H, Ishibashi T, Takahashi S, Yamada S,

Sasano H. Progesterone receptor subtypes in vascular smooth muscle cells of human aorta. Endocrine Journal.

52(2):245-252. 2005 （原著）

468. Seely J, Amigh KS, Suzuki T, Mayhew B, Sasano H, Giguere V, Laganiere J, Carr BR, Rainey WE.

Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor

alpha. Endocrinology. 146(8):3605-3613. 2005 （原著）

469. Fukuda T, Takahashi K, Suzuki T, Saruta M, Watanabe M, Nakata T, Sasano H. Urocortin 1, Urocortin

3/Stresscopin and Corticotropin-Releasing Factor Receptors in Human Adrenal and Its Disorders. Journal of


470. Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H. Urocortin 3/stresscopin in human colon:

possible modulators of gastrointestinal function during stressful conditions. Peptides. 26(7):1196-1206. 2005

（原著）

471. Kariya Y, Moriya T, Suzuki T, Chiba M, Ishida K, Takeyama J, Endoh M, Watanabe M, Sasano H. Sex

steroid hormone receptors in human skin appendage and its neoplasms. Endocrine Journal. 52(3):317-325.

2005 （原著）

472. Sasano H, Anderson TJ, Silverberg SG, Santen RJ, Conway M, Edwards DP, Krause A, Bhatnagar AS,

Evans DB, Miller WR. The validation of new aromatase monoclonal antibodies for immunohistochemistry--a

correlation with biochemical activities in 46 cases of breast cancer. Journal of Steroid Biochemistry and

Molecular Biology. 95(1-5):35-39. 2005 （原著）

473. Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, Moriya T, Hayashi S, Handa M, Kondo T, Sasano

H. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for

endocrine therapy. Cancer Research. 65(14):6450-6458. 2005 （原著）

474. Fukushima K, Funayama Y, Yonezawa H, Takahashi K, Haneda S, Suzuki T, Sasano H, Naito H, Shibata C,

Krozowski ZS, Sasaki I. Aldosterone enhances 11beta-hydroxysteroid dehydrogenase type 2 expression in

colonic epithelial cells in vivo. Scandinavian Journal of Gastroenterology. 40(7):850-857. 2005 （原著）

475. Hirono Y, Doi M, Yoshimoto T, Kanno K, Himeno Y, Taki K, Sasano H, Hirata Y. A case with primary

aldosteronism due to unilateral multiple adrenocortical micronodules. Endocrine Journal. 52(4):435-439. 2005

（原著）

476. Katayama Y, Takata N, Tamura T, Yamamoto A, Hirata F, Yasuda H, Matsukuma S, Daido Y, Sasano H. A

case of primary aldosteronism due to unilateral adrenal hyperplasia. Hypertension Research. 28(4):379-384.

2005 （原著）

477. Sakuma M, Akahira JI, Suzuki T, Inoue S, Ito K, Moriya T, Sasano H, Okamura K, Yaegashi N. Expression

of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian

cancer. Gynecologic Oncology. 99(3):664-670. 2005 （原著）

478. Watanabe S, Suzuki T, Shizawa S, Endoh M, Tabayashi K, Sasano H. Heparin accelerates pulmonary

artery development in neonate rabbits. Tohoku Journal of Experimental Medicine. 207(2):171-179. 2005 （原著）

479. Suzuki T, Urano T, Tsukui T, Horie-Inoue K, Moriya T, Ishida T, Muramatsu M, Ouchi Y, Sasano H, Inoue S.

Estrogen-responsive finger protein as a new potential biomarker for breast cancer. Clinical Cancer Research.

11(17):6148-6154. 2005 （原著）

480. Ishibashi H, Suzuki T, Suzuki S, Moriya T, Kaneko C, Nakata T, Sunamori M, Handa M, Kondo T, Sasano H.

Estrogen inhibits cell proliferation through in situ production in human thymoma. Clinical Cancer Research.

11(18):6495-6504. 2005 （原著）

481. Takahashi K, Arihara Z, Suzuki T, Sone M, Kikuchi K, Sasano H, Murakami O, Totsune K. Expression of

orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.

Peptides. 27(4):871-877. 2005 （原著）

482. Moriya T, Mikami Y, Sakamoto K, Endoh M, Takeyama J, Suzuki T, Mochizuki S, Watanabe M, Monobe Y,

Sasano H. Endocervical-like mucinous borderline tumors of the ovary: clinicopathological features and electron

microscopic findings. Medical Electron Microscopy. 36(4):240-246. 2003 （原著）

483. Saito S, Ito K, Suzuki T, Utsunomiya H, Akahira J, Sugihashi Y, Niikura H, Okamura K, Yaegashi N, Sasano

H. Orphan nuclear receptor DAX-1 in human endometrium and its disorders. Cancer Science. 96(10):645-652.

2005 （原著）

484. Sakamoto K, Watanabe M, De La Cruz C, Honda H, Ise H, Mitsui K, Namiki K, Mikami Y, Moriya T, Sasano

H. Primary invasive micropapillary carcinoma of the colon. Histopathology. 47(5):479-484. 2005 （原著）

485. Ito K, Suzuki T, Akahira J, Sakuma M, Saitou S, Okamoto S, Niikura H, Okamura K, Yaegashi N, Sasano H,

Inoue S. 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer. Clinical

Cancer Research. 11(20):7384-7391. 2005 （原著）

486. Nakamura Y, Otani S, Otaka M, Shimada T, Takahashi S, Saito M, Takahashi T, Komatsu M, Suzuki T,

Okubo S, Hayashi M, Sasano H. Gastric small cell carcinoma with marked response to neoadjuvant

chemotherapy. International Journal of Clinical Oncology. 10(5):348-352. 2005 （原著）

487. Suzuki S, Tsubochi H, Ishibashi H, Matsuda Y, Suzuki T, Krozowski ZS, Sasano H, Kondo T. Inflammatory

Mediators Down-Regulate 11beta-Hydroxysteroid Dehydrogenase Type 2 in a Human Lung Epithelial Cell Line

BEAS-2B and the Rat Lung. Tohoku Journal of Experimental Medicine. 207(4):293-301. 2005 （原著）

488. Taniyama Y, Suzuki T, Mikami Y, Moriya T, Satomi S, Sasano H. Systemic distribution of somatostatin

receptor subtypes in human: an immunohistochemical study. Endocrine Journal. 52(5):605-611. 2005 （原著）

489. Usami S, Moriya T, Kasajima A, Suzuki A, Ishida T, Sasano H, Ohuchi N. Pathological aspects of core

needle biopsy for non-palpable breast lesions. Breast Cancer. 12(4):272-278. 2005 （原著）

490. Suzuki T, Miki Y, Nakamura Y, Moriya T, Ito K, Ohuchi N, Sasano H. Sex steroid-producing enzymes in

human breast cancer. Endocrine Related Cancer. 12(4):701-720. 2005 （総説）

491. Sakamoto K, Kimura N, Tokumura H, Ogasawara T, Moriya T, Sasano H. Hepatoid adenocarcinoma of the

gallbladder. Histopathology. 47(6):649-651. 2005 （原著）

492. Takeyama J, Hayashi T, Saito M, Shimanuki Y, Watanabe M, Sasano H, Shirane R. Spinal hamartoma

associated with spinal dysraphism. Child's Nervous System. 22(9):1098-1102. 2006 （症例）

493. Takahashi K, Kikuchi K, Maruyama Y, Urabe T, Nakajima K, Sasano H, Imai Y, Murakami O, Totsune K.

Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus,

heart and kidney. Peptides. 27(6):1383-1389. 2006 （原著）

494. Suzuki T, Miki Y, Fukuda T, Nakata T, Moriya T, Sasano H. Analysis for localization of steroid sulfatase in

human tissues. Methods in Enzymology. 400:303-316. 2005 （総説）

495. Takahashi K, Totsune K, Saruta M, Fukuda T, Suzuki T, Hirose T, Imai Y, Sasano H, Murakami O.

Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors. Peptides. 27(1):178-182.

2006 （原著）

496. Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H.

Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting

polypeptide-A, in human breast carcinoma. Cancer Research. 66(1):535-542. 2006 （原著）

497. Ito K, Utsunomiya H, Suzuki T, Saitou S, Akahira JI, Okamura K, Yaegashi N, Sasano H.

17beta-Hydroxysteroid dehydrogenases in human endometrium and its disorders. Molecular and Cellular


498. Miki Y, Clyne CD, Suzuki T, Moriya T, Shibuya R, Nakamura Y, Ishida T, Yabuki N, Kitada K, Hayashi SI,

Sasano H. Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: Possible

regulator of insitu steroidogenesis. Cancer Letters. 244(1):24-33. 2006 （原著）

499. Sasano H, Suzuki T. Pathological evaluation of angiogenesis in human tumor. Biomedicine and

Pharmacotherapy. 59 Suppl 2:S334-336. 2005 （総説）

500. Murakami M, Matsui H, Shiraiwa T, Suzuki T, Sasano H, Takahashi E, Kashiwayanagi M. Decreases in

pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits

of voltage-dependent Ca2+-channels. Biological & Pharmaceutical Bulletin. 29(3):437-442. 2006 （原著）

501. Nakamura Y, Suzuki T, Fukuda T, Ito A, Endo M, Moriya T, Arai Y, Sasano H. Steroid sulfatase and

estrogen sulfotransferase in human prostate cancer. Prostate. 66(9):1005-1012. 2006 （原著）

502. Ito O, Nakamura Y, Tan L, Ishizuka T, Sasaki Y, Minami N, Kanazawa M, Ito S, Sasano H, Kohzuki M.

Expression of cytochrome P-450 4 enzymes in the kidney and liver: Regulation by PPAR and species-difference

between rat and human. Molecular and Cellular Biochemistry. 284(1-2):141-148. 2006 （原著）

503. Hatori M, Hosaka M, Watanabe M, Moriya T, Sasano H, Kokubun S. Osteosarcoma in a patient with

neurofibromatosis type 1: a case study and review of the literature. The Tohoku Journal of Experimental

Medicine. 208(4):343-348. 2006 （症例）

504. Moriya T, Kasajima A, Ishida K, Kariya Y, Akahira J, Endoh M, Watanabe M, Sasano H. New trends of

immunohistochemistry for making differential diagnosis of breast lesions. Medical Molecular Morphology.

39(1):8-13. 2006 （原著）

505. Suzuki T, Hayashi S, Miki Y, Nakamura Y, Moriya T, Sugawara A, Ishida T, Ohuchi N, Sasano H.

Peroxisome proliferator-activated receptor gamma in human breast carcinoma: a modulator of estrogenic

actions. Endocrine Related Cancer. 13(1):233-250. 2006 （原著）

506. Fukai N, Hirono Y, Yoshimoto T, Doi M, Ohtsuka Y, Homma K, Shibata H, Sasano H, Hirata Y. A Case of

Estrogen-secreting Adrenocortical Carcinoma with Subclinical Cushing's Syndrome. Endocrine Journal,

53:237-245, 2006 （原著）

507. Ishibashi S, Ohashi Y, Suzuki T, Miyazaki S, Moriya T, Satomi S, Sasano H. Tumor-associated tissue

eosinophilia in human esophageal squamous cell carcinoma. Anticancer Research. 26(2B):1419-1424. 2006

（原著）

508. Sakurai N, Miki Y, Suzuki T, Watanabe K, Narita T, Ando K, Yung TM, Aoki D, Sasano H, Handa H.

Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12. Journal

of Steroid Biochemistry and Molecular Biology. 99(4-5):174-181. 2006 （原著）

509. Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S. A Classic Adamantinoma Arising from

Osteofibrous Dysplasia-Like Adamantinoma in the Lower Leg: A Case study and Review of the Literature.


510. Nakamura Y, Suzuki T, Igarashi K, Kanno J, Furukawa T, Tazawa C, Fujishima F, Miura I, Ando T, Moriyama

N, Moriya T, Saito H, Yamada S, Sasano H. PTOV1: a novel testosterone-induced atherogenic gene in human

aorta. Journal of Pathology. 209(4):522-531. 2006 （原著）

511. Sasano H, Suzuki T, Nakata T, Moriya T. New development in intracrinology of breast carcinoma. Breast

Cancer. 13(2):129-136. 2006 （総説）

512. Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H,

Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y. Neuronal pathway from

the liver modulates energy expenditure and systemic insulin sensitivity. Science. 312(5780):1656-1659. 2006

（原著）

513. Okura T, Miyoshi K, Watanabe S, Kurata M, Irita J, Manabe S, Fukuoka T, Higaki J, Sasano H. Coexistence

of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical

Cushing's syndrome. Clinical and Experimental Nephrology. 10(2):127-130. 2006 （症例）

514. Cheng YH, Imir A, Suzuki T, Fenkci V, Yilmaz B, Sasano H, Bulun SE. SP1 and SP3 Mediate

Progesterone-Dependent Induction of the 17beta Hydroxysteroid Dehydrogenase Type 2 Gene in Human

Endometrium. Biology of reproduction. 75(4):605-614. 2006 （原著）

515. Nakamura Y, Shimada N, Suzuki T, Imatani A, Sekine H, Ohara S, Shimosegawa T, Sasano H. In situ

androgen production in human gastric carcinoma--androgen synthesizing and metabolizing enzymes.

Anticancer Res. 26(3A):1935-1939. 2006 （原著）

516. Ota K, Ito K, Suzuki T, Saito S, Tamura M, Hayashi S, Okamura K, Sasano H, Yaegashi N. Peroxisome

proliferator-activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma. Clin

Cancer Res. 12(14 Pt 1):4200-4208. 2006 （原著）

517. Sasano H, Suzuki T. Chemoprevention of breast cancer among Asian women--its perspective and

problems. Biomedecine & pharmacotherapie. 60(6):266-268. 2006 （総説）

518. Nakamura Y, Suzuki S, Suzuki T, Ono K, Miura I, Satoh F, Moriya T, Saito H, Yamada S, Ito S, Sasano H.

MDM2: A Novel Mineralocorticoid-Responsive Gene Involved in Aldosterone-Induced Human Vascular

Structural Remodeling. American journal of Pathology. 169(2):362-371. 2006 （原著）

519. Ikarashi T, Kamoi K, Asakawa K, Tanaka M, Miyakoshi M, Komeyama T, Morishita H, Usuda H, Emura I,

Sasano H. A Case of Preclinical Cushing's Syndrome Associated with Diurnal Rhythms of ACTH and Cortisol in

Blood: Correlation with Histological Findings. Endocrine journal. 53(5):609-613. 2006 （症例）

520. Imai J, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Uno K, Hasegawa Y, Gao J, Ishihara H, Sasano H, Oka

Y. Cold exposure suppresses serum adiponectin levels through sympathetic nerve activation in mice. Obesity.

14(7):1132-1141. 2006 （総説）

521. Saito S, Ito K, Nagase S, Suzuki T, Akahira JI, Okamura K, Yaegashi N, Sasano H. Progesterone receptor

isoforms as a prognostic marker in human endometrial carcinoma. Cancer science. 97(12):1308-1314. 2006

（原著）

522. Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, Sasano H, Kokubun S. Expression profiles of

sex steroid receptors in desmoid tumors. Tohoku journal of experimental medicine. 210(3):189-198. 2006 （原

著）

523. Hatori M, Doi H, Watanabe M, Sasano H, Hosaka M, Kotajima S, Urano F, Hata J, Kokubun S.

Establishment and Characterization of a Clonal Human Extraskeletal Ewing's Sarcoma Cell Line, EES1. Tohoku

journal of experimental medicine. 210(3):221-230. 2006 （原著）

524. Ohba T, Watanabe H, Takahashi Y, Suzuki T, Miyoshi I, Nakayama S, Satoh E, Iino K, Sasano H, Mori Y,

Kuromitsu S, Imagawa K, Saito Y, Iijima T, Ito H, Murakami M. Regulatory role of neuron-restrictive silencing

factor in expression of TRPC1. Biochemical and biophysical research communications. 351(3):764-770. 2006

（原著）

525. Omura M, Sasano H, Saito J, Yamaguchi K, Kakuta Y, Nishikawa T. Clinical characteristics of

aldosterone-producing microadenoma, macroadenoma, and idiopathic hyperaldosteronism in 93 patients with

primary aldosteronism. Hypertens Res. 29(11):883-889. 2006 （原著）

526. Sasano H, Suzuki T, Moriya T. Recent advances in histopathology and immunohistochemistry of

adrenocortical carcinoma. Endocr Pathol. 17(4):345-354. 2006 （総説）

527. Kobayashi S, Kubo H, Suzuki T, Ishizawa K, Yamada M, He M, Yamamoto Y, Yamamoto H, Sasano H,

Sasaki H, Suzuki S. Endogenous Secretory Receptor for Advanced Glycation Endproducts in Non-Small Cell

Lung Carcinoma. American journal of respiratory and critical care medicine. 175(2):184-189. 2007 （原著）

528. Suzuki T, Miki Y, Moriya T, Akahira JI, Ishida T, Hirakawa H, Yamaguchi Y, Hayashi SI, Sasano H.

5alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production.

International journalof cancer. Journal international du cancer. 120(2):285-291. 2007 （原著）

529. Miki Y, Suzuki T, Hatori M, Igarashi K, Aisaki KI, Kanno J, Nakamura Y, Uzuki M, Sawai T, Sasano H.

Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: A possible androgenic bone

protective effects induced by exemestane. Bone. 40(4):876-87. 2007 （原著）

530. Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H,

Nakauchi H, Oka Y, Katagiri H. Bone marrow (BM) transplantation promotes beta-cell regeneration after acute

injury through BM cell mobilization. Endocrinology. 148(5):2006-2015. 2007 （原著）

531. Sakuma M, Akahira J, Ito K, Niikura H, Moriya T, Okamura K, Sasano H, Yaegashi N. Promoter methylation

status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. Cancer

science. 98(3):380-386. 2007 （原著）

532. Murakami M, Ohba T, Wu TW, Fujisawa S, Suzuki T, Takahashi Y, Takahashi E, Watanabe H, Miyoshi I,

Ono K, Sasano H, Ito H, Iijima T. Modified sympathetic regulation in N-type calcium channel null-mouse.

Biochemical and biophysical research communications. 354(4):1016-1020. 2007（原著）

533. Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Sasano

H, Koike T. Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged

woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. Journal of

Endocrinological Investigation. 30(1):65-69. 2007 （症例）

534. Morimoto R, Satoh F, Murakami O, Totsune K, Suzuki T, Sasano H, Ito S, Takahashi K. Expression of

adrenomedullin2/intermedin in human brain, heart, and kidney. Peptides. 28(5):1095-103. 2007 （原著）

535. Suzuki T, Urano T, Miki Y, Moriya T, Akahira J, Ishida T, Horie K, Inoue S, Sasano H. Nuclear cyclin B1 in

human breast carcinoma as a potent prognostic factor. Cancer Science. 98(5):644-51. 2007 （原著）

536. Nagase S, Mikami Y, Moriya T, Niikura H, Yoshinaga K, Takano T, Ito K, Akahira J, Sasano H, Yaegashi N.

Vaginal tumors with histologic and immunocytochemical feature of gastrointestinal stromal tumor: two cases and

review of the literature. International Journal of Gynecological Cancer. 17(4):928-933. 2007 （原著）

537. Saito T, Ikoma A, Saito T, Tamemoto H, Suminaga Y, Yamada S, Kawakami M, Suzuki T, Sasano H,

Ishikawa SE. Possibly Simultaneous Primary Aldosteronism and Preclinical Cushing's Syndrome in a Patient

with Double Adenomas of Right Adrenal Gland. Endocr J. 54(2):287-293. 2007 （症例）

538. Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young

J, Chanson P. Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens. Clinical

Endocrinology. 66(6):778-788. 2007 （症例）

539. Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans DB, Hayashi S,

Ohuchi N, Sasano H. Aromatase localization in human breast cancer tissues: possible interactions between

intratumoral stromal and parenchymal cells. Cancer Research. 67(8):3945-3954. 2007 （原著）

540. Usami S, Moriya T, Amari M, Suzuki A, Ishida T, Sasano H, Ohuchi N. Reliability of prognostic factors in

breast carcinoma determined by core needle biopsy. Japanese Journal of Clinical Oncology. 37(4):250-255.

2007 （原著）

541.Tokunaga H, Akahira J, Suzuki T, Moriya T, Sasano H, Ito K, Yaegashi N. Ovarian epithelial carcinoma with

estrogen-producing stroma. Pathology International. 57(5):285-290. 2007 （原著）

542. Kahara T, Seto C, Uchiyama A, Usuda D, Akahori H, Tajika E, Miwa A, Usuda R, Suzuki T, Sasano H.

Preclinical Cushing's Syndrome Resulting from Adrenal Black Adenoma Diagnosed with Diabetic Ketoacidosis.

Endocr J. 54(4):543-551. 2007 （症例）

543. Miki Y, Suzuki T, Sasano H. Controversies of aromatase localization in human breast cancer-Stromal

versus parenchymal cells. The Journal of Steroid Biochemistry and Molecular Biology. 106(1-5):97-101. 2007

（総説）

544. Wick MR, Foucar E, Allen PW, Alves VA, Bjornsson J, Bosman F, Churg AW, Drut R, Foster CS,

Hauptmann S, Hytiroglou P, Kuo TT, Matsubara O, Nappi O, Pervez S, Rosai J, Sasano H, Vielh P, Zelger B.

Medicolegal liability in pathology: an international perspective. Seminars in Diagnostic Pathology. 24(2):65-76.

2007 （総説）

545. Suzuki T, Inoue A, Miki Y, Moriya T, Akahira J, Ishida T, Hirakawa H, Yamaguchi Y, Hayashi S, Sasano H.

Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a

potent prognostic factor. Endocrine- Related Cancer. 14(2):279-292. 2007 （原著）

546. Ito T, Tanaka M, Sasano H, Osamura YR, Sasaki I, Kimura W, Takano K, Obara T, Ishibashi M, Nakao K,

Doi R, Shimatsu A, Nishida T, Komoto I, Hirata Y, Imamura M, Kawabe K, Nakamura K; Neuroendocrine Tumor

Workshop of Japan. Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal

tumors. Journal of Gastroenterology. 42(6):497-500. 2007 （原著）

547. Akahira JI, Tokunaga H, Toyoshima M, Takano T, Nagase S, Yoshinaga K, Tase T, Wada Y, Ito K, Niikura H,

Yamada H, Sato A, Sasano H, Yaegashi N. Prognoses and Prognostic Factors of Carcinosarcoma, Endometrial

Stromal Sarcoma and Uterine Leiomyosarcoma: A Comparison with Uterine Endometrial Adenocarcinoma.

Oncology. 71(5-6):333-340. 2006 （原著）

548. Ono K, Suzuki T, Miki Y, Taniyama Y, Nakamura Y, Noda Y, Watanabe M, Sasano H. Somatostatin receptor

subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on

cell proliferation in cell line NCI-H727. Anticancer Research. 27(4B):2231-2239. 2007 （原著）

549. Muto M, Onogawa T, Suzuki T, Ishida T, Rikiyama T, Katayose Y, Ohuchi N, Sasano H, Abe T, Unno M.

Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma.

Cancer Science. 98(10):1570-1576. 2007 （原著）

550. Nakamura Y, Suzuki T, Sasano H. Transcription Factor GATA-6 in the Human Adrenocortex: Association

with Adrenal Development and Aging. Endocrine Journal. 54(5):783-789. 2007 （原著）

551. Ito K, Utsunomiya H, Yaegashi N, Sasano H. Biological Roles of Estrogen and Progesterone in Human

Endometrial Carcinoma - New Developments in Potential Endocrine Therapy for Endometrial Cancer - Endocr J.

54(5):667-679. 2007 （総説）

552. Suzuki T, Miki Y, Moriya T, Akahira J, Hirakawa H, Ohuchi N, Sasano H. In situ production of sex steroids in

human breast carcinoma. Medical Molecular Morphology. 40(3):121-127. 2007 （総説）

553. LooWT. Sasano H. Chow LW. Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are

involved in wound healing after mastectomy in invasive breast cancer patients. Biomedicine & Pharmacotherapy.

61 (9):548-552. 2007 （原著）

554. LooWT.Sasano H. Chow LW. Effects of capecitabine and vinorelbine on cell proliferation, metabolism and

COX2 and p16 expression in breast cancer cell lines and solid tumour tissues. Biomedicine & Pharmacotherapy.

61(9):596-600. 2007 （原著）

555. Miki Y, Suzuki T, Sasano H. Aromatase inhibitor and bone. Biomedicine & Pharmacotherapy.

61(9):540-542. 2007 （総説）

556. Sasano H, Suzuki T, Moriya T. Analysis of surrogate markers for target-specific therapy in breast

carcinomas using archival materials. Biomedicine & Pharmacotherapy. 61(9):543-547. 2007 （総説）

557. LooWT.Sasano H. Chow LW. Evaluation of therapeutic efficacy of capecitabine on human breast

carcinoma tissues and cell lines in vitro. Biomedicine & Pharmacotherapy. 61(9):553-557. 2007 （原著）

558. Akahira J, Suzuki F, Suzuki T, Miura I, Kamogawa N, Miki Y, Ito K, Yaegashi N, Sasano H. Decreased

expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: Correlation with

epigenetic inactivation by aberrant DNA methylation. Pathology International. 57(11):725-733. 2007 （原著）

559. Sasano H, Suzuki T, Miki Y, Moriya T. Intracrinology of estrogens and androgens in breast carcinoma. The

Journal of Steroid Biochemistry and Molecular Biology. 108(3-5):181-185. 2008 （総説）

560. Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM,

Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME. Hormonal markers in breast cancer:

coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based

study. Cancer Research. 67(21):10608-10617. 2007 （原著）

561. Ito M, Moriya T, Ishida T, Usami S, Kasajima A, Sasano H, Ohuchi N. Significance of pathological

evaluation for lymphatic vessel invasion in invasive breast cancer. Breast Cancer. 14(4):381-387. 2007 （原著）

562. Nakamura Y, Aoki S, Xing Y, Sasano H, Rainey WE. Metastin stimulates aldosterone synthesis in human

adrenal cells. Reprod Sci. 14(8):836-845. 2007 （原著）

563. Satoh F, Abe T, Tanemoto M, Nakamura M, Abe M, Uruno A, Morimoto R, Sato A, Takase K, Ishidoya S,

Arai Y, Suzuki T, Sasano H, Ishibashi T, Ito S. Localization of aldosterone-producing adrenocortical adenomas:

significance of adrenal venous sampling. Hypertens Res. 30(11):1083-1095. 2007 （原著）

564. Tamura Y, Adachi J, Chiba Y, Mori S, Takeda K, Kasuya Y, Murayama T, Sawabe M, Sasano H, Araki A, Ito

H, Horiuchi T. Primary aldosteronism due to unilateral adrenal microadenoma in an elderly patient: efficacy of

selective adrenal venous sampling. Intern Med. 47(1):37-42. 2008 （症例）

565. Dowsett M, Allred C, Knox J, Quinn E, Salter J, Wale C, Cuzick J, Houghton J, Williams N, Mallon E, Bishop

H, Ellis I, Larsimont D, Sasano H, Carder P, Cussac AL, Knox F, Speirs V, Forbes J, Buzdar A. Relationship

between quantitative estrogen and progesterone receptor expression and human epidermal growth factor

receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial. J Clin Onco.

26(7):1059-1065. 2008 （原著）

566. Leung AM, Sasano H, Nishikwa T, McAneny DB, Malabanan AO. Multiple unilateral adrenal adenomas in a

patient with primary hyperaldosteronism. Endocr Pract. 14(1):76-79. 2008 （症例）

567. Takahashi S, Moriya T, Ishida T, Shibata H, Sasano H, Ohuchi N, Ishioka C. Prediction of breast cancer

prognosis by gene expression profile of TP53 status. Cancer Sci. 99(2):324-332. 2008 （原著）

http://www.ncbi.nlm.nih.gov/pubmed/18227529?ordinalpos=52&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum



http://www.ncbi.nlm.nih.gov/pubmed/18271932?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

568. Shibuya R, Suzuki T, Miki Y, Yoshida K, Moriya T, Ono K, Akahira JI, Ishida T, Hirakawa H, Evans DB,

Sasano H. Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in

ductal carcinoma in situ of human breast. Endocr Relat Cancer. 15(1):113-124. 2008 （原著）

569. Nigawara T, Kageyama K, Sakihara S, Takayasu S, Kawahara M, Imai A, Ohyama C, Usui T, Sasano H,

Suda T. male case of nonclassical 21-hydroxylase deficiency first manifested in his sixties with adrenocortical

incidentaloma. Endocr J. 55(2):291-297. 2008 （症例）

570. Kanto S, Sugawara J, Masuda H, Sasano H, Arai Y, Kyono K. Fresh motile testicular sperm retrieved from

nonobstructive azoospermic patients has the same potential to achieve fertilization and pregnancy via ICSI as

sperm retrieved from obstructive azoospermic patients. Fertil Steril. 90(5):2010.e5-7. 2008 （原著）

571. Takeyama J, Sasano H, Fukumoto M. Giant chordoma occupying the whole abdominal cavity. Pathology.

40(3):313-314. 2008 （症例）

572. Morimoto R, Satoh F, Murakami O, Hirose T, Totsune K, Imai Y, Arai Y, Suzuki T, Sasano H, Ito S,

Takahashi K. Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic

adrenal tissues. J Endocrinol. 198(1):175-183. 2008 （原著）

573. Suzuki T, Miki Y, Akahira J, Moriya T, Ohuchi N, Sasano H. Aromatase in human breast carcinoma as a key

regulator of intratumoral sex steroid concentrations. Endocr J. 55(3):455-463. 2008 （総説）

574. Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H,

Yaegashi N, Hayashi SI. Estrogen signaling ability in human endometrial cancer through the cancer-stromal

interaction. Endocr Relat Cancer. 15(2):451-463. 2008 （原著）

575. Oki K, Yamane K, Sakashita Y, Kamei N, Watanabe H, Toyota N, Shigeta M, Sasano H, Kohno N. Primary

aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas. Clin Exp Nephrol.

12(5):382-7. 2008 （原著）

576. Baba Y, Beppu T, Imai K, Masuda T, Iyama KI, Sasano H, Baba H. A case of adrenal rest tumor of the liver:

Radiological imaging and immunohistochemical study of steroidogenic enzymes. Hepatol Res.

38(11):1154-1158. 2008 （症例）

577. Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J, Honma S, Evans DB, Hayashi SI, Kondo T,

Sasano H. Intratumoral Estrogens and Estrogen Receptors in Human Non-Small Cell Lung Carcinoma. Clin

Cancer Res. 14(14):4417-4426. 2008 （原著）

578. Suzuki T, Miki Y, Ohuchi N, Sasano H. Intratumoral estrogen production in breast carcinoma: significance

of aromatase. Breast Cancer. 15(4):270-277. 2008 （総説）

579. Murakami M, Ohba T, Xu F, Satoh E, Miyoshi I, Suzuki T, Takahashi Y, Takahashi E, Watanabe H, Ono K,

Sasano H, Kasai N, Ito H, Iijima T. Modified sympathetic nerve system activity with over-expression of the

voltage-dependent calcium channel beta 3 subunit. J Biol Chem. 283(36):24554-24560. 2008 （原著）

580. Morimoto R, Satoh F, Murakami O, Totsune K, Saruta M, Suzuki T, Sasano H, Ito S, Takahashi K.

Expression of peptide YY in human brain and pituitary tissues. Nutrition. 24(9):878-884. 2008 （原著）











581. Hirose T, Totsune K, Mori N, Morimoto R, Hashimoto M, Nakashige Y, Metoki H, Asayama K, Kikuya M,

Ohkubo T, Hashimoto J, Sasano H, Kohzuki M, Takahashi K, Imai Y. Increased expression of adrenomedullin

2/intermedin in rat hearts with congestive heart failure. Eur J Heart Fail. 10(9):840-849. 2008 （原著）

582. Miller WR, Bartlett J, Brodie AM, Brueggemeier RW, di Salle E, Lønning PE, Llombart A, Maass N,

Maudelonde T, Sasano H, Goss PE. Aromatase Inhibitors: Are There Differences Between Steroidal and

Nonsteroidal Aromatase Inhibitors and Do They Matter? Oncologist. 13(8):829-837. 2008 （総説）

583. Kaku U, Kameyama K, Izawa M, Yamada M, Miyamoto J, Suzuki T, Sasano H, Hasegawa Y. Ovarian

Histological Findings in an Adult Patient with the Steroidogenic Acute Regulatory Protein (StAR) Deficiency

Reveal the Impairment of Steroidogenesis by Lipoid Deposition. Endocr J. 55(6):1043-1049. 2008 （原著）

584. Nakamura Y, Suzuki T, Arai Y, Sasano H. Nuclear Receptor DAX1 in human prostate cancer: a novel

independent biological modulator. Endocr J. 56(1): 39-44. 2008 （原著）

585. Ellis MJ, Miller WR, Tao Y, Evans DB, Chaudri Ross HA, Miki Y, Suzuki T, Sasano H. Aromatase

expression and outcomes in the P024 neoadjuvant endocrine therapy trial. Breast Cancer Res Treat.

116(2):371-378. 2008 （原著）

586. Umemura S, Osamura RY, Akiyama F, Honma K, Kurosumi M, Sasano H, Toyoshima S, Tsuda H, Rüschoff

J, Sakamoto G. What causes discrepancies in HER2 testing for breast cancer? A Japanese ring study in

conjunction with the global standard. Am J Clin Pathol. 130(6):883-891. 2008 （原著）

587. Suzuki F, Akahira J, Miura I, Suzuki T, Ito K, Hayashi S, Sasano H, Yaegashi N. Loss of estrogen receptor

beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in

human epithelial ovarian carcinoma. Cancer Sci. 99(12):2365-2372. 2008 （原著）

588. Terada Y, Terunuma-Sato Y, Kakoi-Yoshimoto T, Hasegawa H, Ugajin T, Koyanagi Y, Ito M, Murakami T,

Sasano H, Yaegashi N, Okamura K. Development of human Graafian follicles following transplantation of

human ovarian tissue into NOD/SCID/gammacnull mice. Am J Reprod Immunol. 60(6):534-540. 2008 （原著）

589. Ye P, Yamashita T, Pollock DM, Sasano H, Rainey WE. Contrasting Effects of Eplerenone and

Spironolactone on Adrenal Cell Steroidogenesis. Horm Metab Res. 41(1):35-39. 2009 （原著）

590. Nakamura Y, Vargas Morris C, Sasano H, Rainey WE. DAX-1A (NR0B1A) Expression Levels are

Extremely Low Compared to DAX-1 (NR0B1) in Human Steroidogenic Tissues. Horm Metab Res. 41(1):30-34.

2009 （原著）

591.Nakamura Y, Gang HX, Suzuki T, Sasano H, Rainey WE. Adrenal changes associated with adrenarche.

Rev Endocr Metab Disord. 10(1):19-26. 2009 （総説）

592. Sone M, Shibata H, Homma K, Tamura N, Akahira J, Hamada S, Yahata M, Fukui N, Itoh H, Sasano H,

Nakao K. Close examination of steroidogenesis disorders in a DOC- and progesterone-producing

adrenocortical carcinoma. Endocrine J. 35(1):25-33. 2009 （症例）

593. Sakamoto N, Tojo K, Saito T, Fujimoto K, Isaka T, Tajima N, Ikeda K, Yamada H, Furuta N, Sasano H.

Coexistence of Aldosterone-Producing adrenocortical adenoma and Pheochromocytoma in an ipsilateral





adrenal gland. Endocr J. 56(2):213-219. 2009 （症例）

594. Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, Yoshinaga K, Ohuchi N, Sasano H. Vasohibin-1 in human

breast carcinoma: a potential negative feedback regulator of angiogenesis. Cancer Sci. 100(1):88-94. 2009 （原

著）

595. Ebisawa T, Tojo K, Tajima N, Kamio M, Oki Y, Ono K, Sasano H. Immunohistochemical Analysis of

11-beta-Hydroxysteroid Dehydrogenase Type 2 and Glucocorticoid Receptor in Subclinical Cushing's Disease

due to Pituitary Macroadenoma. Endocr Pathol. 19(4):252-260. 2008 （原著）

596. Takayama K, Tsutsumi S, Suzuki T, Horie-Inoue K, Ikeda K, Kaneshiro K, Fujimura T, Kumagai J, Urano T,

Sakaki Y, Shirahige K, Sasano H, Takahashi S, Kitamura T, Ouchi Y, Aburatani H, Inoue S. Amyloid precursor

protein is a primary androgen target gene that promotes prostate cancer growth. Cancer Res. 69(1):137-142.

2009 （原著）

597. Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S,

Yamamoto K, Ii T, Egawa S, Evans DB, Unno M, Sasano H. Steroid Sulfatase and Estrogen Sulfotransferase in

Colon Carcinoma: Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors. Cancer

Res. 69(3):914-922. 2009 （原著）

598. Nagasaki S, Suzuki T, Miki Y, Akahira JI, Shibata H, Ishida T, Ohuchi N, Sasano H. Chicken ovalbumin

upstream promoter transcription factor II in human breast carcinoma: Possible regulator of lymphangiogenesis

via vascular endothelial growth factor-C expression. Cancer Sci. 100(4):639-645. 2009 （原著）

599．Nakamura M, Miki Y, Akahira JI, Morimoto R, Satoh F, Ishidoya S, Arai Y, Suzuki T, Hayashi Y, Sasano H.

An Analysis of Potential Surrogate Markers of Target-Specific Therapy in Archival Materials of Adrenocortical

Carcinoma. Endocr Pathol. 20(1):17-23. 2009 （原著）

600. Nagasaki S, Suzuki T, Miki Y, Akahira J, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H.

17Beta-hydroxysteroid dehydrogenase type 12 in human breast carcinoma: a prognostic factor via potential

regulation of fatty acid synthesis. Cancer Res. 69(4):1392-1399. 2009 （原著）

601. Nigawara T, Sakihara S, Kageyama K, Terui K, Takayasu S, Hatakeyama S, Ohyama C, Sasano H, Suda T.

Endothelial cyst of the adrenal gland associated with adrenocortical adenoma: preoperative images simulate

carcinoma. Intern Med. 48(4):235-240. 2009 （症例）

602. Nagasaki S, Miki Y, Akahira J, Suzuki T, Sasano H. 17beta-hydroxysteroid dehydrogenases in human

breast cancer. Ann N Y Acad Sci. 1155:25-32. 2009 （総説）

603. Sasano H, Nagasaki S, Miki Y, Suzuki T. New developments in intracrinology of human breast cancer:

estrogen sulfatase and sulfotransferase. Ann N Y Acad Sci. 1155:76-79. 2009 （総説）

604. Kimura T, Usui T, Inamoto S, Minamiguchi S, Okuno H, Sasano H, Hagiwara H, Nagata D, Tagami T,

Naruse M, Shimatsu A. Image in endocrinology. Pheochromocytoma with Subclinical Cushing's Syndrome

Caused by Corticomedullary Mixed Tumor of the Adrenal Gland. J Clin Endocrinol Metab. 94(3):746-747. 2009

（症例）

605. Nakamura Y, Hornsby PJ, Casson P, Morimoto R, Satoh F, Xing Y, Kennedy MR, Sasano H, Rainey WE.


Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal

reticularis. J Clin Endocrinol Metab. 94(6):2192-2198. 2009 （原著）

606. Miki Y, Suzuki T, Nagasaki S, Hata S, Akahira J, Sasano H. Comparative effects of raloxifene, tamoxifen

and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene.

J Steroid Biochem Mol Biol. 113(3-5):281-289. 2009 （原著）

607.Nakamura Y, Suzuki T, Sugawara A, Arai Y, Sasano H. Peroxisome proliferator-activated receptor gamma

in human prostate carcinoma. Pathol Int. 59(5):288-293. 2009 （原著）

608. Nakamura Y, Suzuki T, Arai Y, Sasano H. 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b)

expression in human prostate cancer. Neoplasma. 56(4):317-320. 2009 （原著）

609. Nakamura Y, Xing Y, Sasano H, Rainey WE. The mediator complex subunit 1 enhances transcription of

genes needed for adrenal androgen production. Endocrinology. 150(9):4145-4153. 2009 （原著）

610. Lykkesfeldt AE, Henriksen KL, Rasmussen BB, Sasano H, Evans DB, Møller S, Ejlertsen B, Mouridsen HT.

In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not

predictive of response to endocrine therapy in advanced breast cancer. BMC Cancer. 9:185. 2009 （原著）

611. Nagasaki S, Miki Y, Akahira J, Suzuki T, Sasano H. Transcriptional regulation of 17beta-hydroxysteroid

dehydrogenase type 12 by SREBP-1. Mol Cell Endocrinol. 307(1-2):163-168. 2009 （原著）

612. Loo WT, Chow LW, Suzuki T, Ono K, Ishida T, Hirakawa H, Ohuchi N, Sasano H. Expression of thymidine

phosphorylase and dihydropyrimidine dehydrogenase in human breast carcinoma cells and tissues. Anticancer

Res 29(7):2525-2530. 2009 （原著）

613. Miyoshi Y, Oue T, Oowari M, Soh H, Tachibana M, Kimura S, Kiyohara Y, Yamada H, Bessyo K, Mushiake

S, Homma K, Hasegawa T, Sasano H, Ozono K. A Case of Pediatric Virilizing Adrenocortical Tumor Resulting

in Hypothalamic-pituitary Activation and Central Precocious Puberty Following Surgical Removal. Endocr J.

56(8):975-982. 2009 （症例）

614. Hui XG, Akahira J, Suzuki T, Nio M, Nakamura Y, Suzuki H, Rainey WE, Sasano H. Development of the

human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence. J

Endocrinol. 203(2):241-252. 2009 （原著）

615. Sasano H, Miki Y, Shibuya R, Suzuki T. Aromatase and in situ estrogen production in DCIS (ductal

carcinoma in situ) of human breast. J Steroid Biochem Mol Biol. 118(4-5):242-245. 2010 （総説）

616. Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, Kudo N, Koguchi M, Niikawa H, Suzuki S, Evans DB,

Sugawara S, Suzuki T, Sasano H. Highly concordant coexpression of aromatase and estrogen receptor beta in

non-small cell lung cancer. Hum Pathol. 41(2):190-198. 2010 （原著）

617.Kyono K, Doshida M, Toya M, Sato Y, Akahira J, Sasano H. Potential indications for ovarian

autotransplantation based on the analysis of 5,571 autopsy findings of females under the age of 40 in Japan.

Fertil Steril. 93(7):2429-2430. 2010 （原著）

618. Matsumoto M, Sakamoto H, Yamaguchi Y, Seino Y, Takei H, Kurosumi M, Sasano H, Yaegashi N, Hayashi









S. 3-Dimensional microarray analysis of estrogen signal-related genes in breast cancer tissues. Anticancer Res.

29(10):3971-3975. 2009 （原著）

619. Sasano H. Steroid hormones are produced at the sites of action. Endocr J. 56(7):825-826. 2009 （総説）

620. Takeyama D, Miki Y, Fujishima F, Suzuki T, Akahira JI, Hata S, Miyata G, Satomi S, Sasano H. Steroid and

xenobiotic receptor in human esophageal squamous cell carcinoma: A potent prognostic factor. Cancer Sci.

101(2):543-549. 2010 （原著）

621. Sasano H, Miki Y, Nagasaki S, Suzuki T. In situ estrogen production and its regulation in human breast

carcinoma: from endocrinology to intracrinology. Pathol Int. 59(11):777-789. 2009 （総説）

622. Geisler J, Suzuki T, Helle H, Miki Y, Nagasaki S, Duong NK, Ekse D, Aas T, Evans DB, Lønning PE,

Sasano H. Breast cancer aromatase expression evaluated by the novel antibody 677: Correlations to

intra-tumor estrogen levels and hormone receptor status. J Steroid Biochem Mol Biol. 118(4-5):237-241. 2010

（原著）

623. Hiroki E, Akahira JI, Suzuki F, Nagase S, Ito K, Suzuki T, Sasano H, Yaegashi N. Changes in microRNA

expression levels correlate with clinicopathological features and prognoses in endometrial serous

adenocarcinomas. Cancer Sci. 101(1):241-249. 2010 （原著）

624.Hong Y, Li H, Ye J, Miki Y, Yuan YC, Sasano H, Evans DB, Chen S. Epitope characterization of an

aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. PLoS One.

4(11):e8050. 2009 （原著）

625. Nomura M, Sasano H, Okada Y, Watanabe T, Sakamoto S, Sakiyama Y, Sakamoto R, Abe I, Horiuchi T,

Yanase T, Takayanagi R. Adrenal failure caused by a retroperitoneal malignant mesothelioma. Intern Med.

48(24):2109-2114. 2009 （症例）

626. Ito T, Sasano H, Tanaka M, Osamura RY, Sasaki I, Kimura W, Takano K, Obara T, Ishibashi M, Nakao K,

Doi R, Shimatsu A, Nishida T, Komoto I, Hirata Y, Nakamura K, Igarashi H, Jensen RT, Wiedenmann B, Imamura

M. Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan. J Gastroenterol.

45(2):234-243. 2010 （原著）

627. Hata S, Miki Y, Fujishima F, Sato R, Okaue A, Abe K, Ishida K, Akahira J, Unno M, Sasano H. Cytochrome

3A and 2E1 in human liver tissue: Individual variations among normal Japanese subjects. Life Sci.

86(11-12):393-401. 2010 （原著）

628. Sasano H, Miki Y. Bone and Men's Health. Effects of aromatase inhibitors on human osteoblasts Clin

Calcium. 20(2):189-197. 2010 （総説）

629. Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N,

Watanabe M, Ishida T, Ohuchi N. Vasohibin-1 as a potential predictor of aggressive behavior of ductal

carcinoma in situ of the breast. Cancer Sci. 101(4):1051-1058. 2010 （原著）

630. Ohta T, Ohba T, Suzuki T, Watanabe H, Sasano H, Murakami M. Decreased calcium channel currents and

facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice. Biochem Biophys Res Commun.

394(3):464-469. 2010 （原著）

http://www.ncbi.nlm.nih.gov/pubmed/20058030

631. Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Chan MS, Miki Y, Saji S, Ueno T, Toi M, Sasano H.

Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following

neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat. 120(3):639-648.

2010 （原著）

632. Fukamachi K, Ishida T, Usami S, Takeda M, Watanabe M, Sasano H, Ohuchi N. Total-Circumference

Intraoperative Frozen Section Analysis Reduces Margin-Positive Rate in Breast-Conservation Surgery. Jpn J

Clin Oncol. 40(6):513-520. 2010 （原著）

633. Takagi K, Miki Y, Nagasaki S, Hirakawa H, Onodera Y, Akahira J, Ishida T, Watanabe M, Kimijima I, Hayashi

S, Sasano H, Suzuki T. Increased intratumoral androgens in human breast carcinoma following aromatase

inhibitor exemestane treatment. Endocr Relat Cancer. 17(2):415-430. 2010 （原著）

634. Sasano H. Histopathological prognostic factors in early breast carcinoma: an evaluation of cell proliferation

in carcinoma cells. Expert Opin Investig Drugs. 19 Suppl 1:S5-S11. 2010 （総説）

635. Yiu CC, Sasano H, Ono K, Chow LW. Changes in protein expression after neoadjuvant use of aromatase

inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response

or resistance. Expert Opin Investig Drugs. 19 Suppl 1:S79-S89. 2010 （原著）

636. Takahashi K, Yamamoto H, Hirose T, Hiraishi K, Shoji I, Shibasaki A, Kato I, Kaneko K, Sasano H, Satoh F,

Totsune K. Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic

nephropathy. Peptides. 31(7):1405-1408. 2010 （原著）

637. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G,

Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S,

Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G,

Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American society of clinical oncology/college of

american pathologists guideline recommendations for immunohistochemical testing of estrogen and

progesterone receptors in breast cancer. J Oncol Pract. 6(4):195-197. 2010 （原著）

638. O'Toole D, Rindi G, Plöckinger U, Sasano H, Wiedenmann B; ENETS. ENETS consensus guidelines for

the management of patients with rare metastases from digestive neuroendocrine tumors: rationale and working

framework. Introduction. Neuroendocrinology. 91(4):324-325. 2010 （原著）

639. Kianmanesh R, Ruszniewski P, Rindi G, Kwekkeboom D, Pape UF, Kulke M, Sevilla Garcia I, Scoazec JY,

Nilsson O, Fazio N, Sasano H, Lesurtel M, Chen YJ, Eriksson B, Cioppi F, O'Toole D; Palma de Mallorca

Consensus Conference Participants. ENETS consensus guidelines for the management of peritoneal

carcinomatosis from neuroendocrine tumors. Neuroendocrinology. 91(4):333-340. 2010 （原著）

640. Pavel M, Grossman A, Arnold R, Perren A, Kaltsas G, Steinmüller T, de Herder W, Nikou G, Plöckinger U,

Lopes JM, Sasano H, Buscombe J, Lind P, O'Toole D, Oberg K; Palma de Mallorca Consensus Conference

Participants. ENETS consensus guidelines for the management of brain, cardiac and ovarian metastases from

neuroendocrine tumors. Neuroendocrinology. 91(4):326-332. 2010 （原著）

641. Morimoto R, Kudo M, Murakami O, Takase K, Ishidoya S, Nakamura Y, Ishibashi T, Takahashi S, Arai Y,

Suzuki T, Sasano H, Ito S, Satoh F. Difficult-to-control hypertension due to bilateral aldosterone-producing

adrenocortical microadenomas associated with a cortisol-producing adrenal macroadenoma. J Hum Hypertens.

25(2):114-121. 2011 （原著）

642. Kos-Kudła B, O'Toole D, Falconi M, Gross D, Klöppel G, Sundin A, Ramage J, Oberg K, Wiedenmann B,

Komminoth P, Sasano H, Van Custem E, Mallath M, Papotti M, Caplin M; Palma de Mallorca Consensus

Conference Participants. ENETS consensus guidelines for the management of bone and lung metastases from

neuroendocrine tumors. Neuroendocrinology. 91(4):341-350. 2010 （原著）

643. Tamaki K, Sasano H, Ishida T, Ishida K, Miyashita M, Takeda M, Amari M, Harada-Shoji N, Kawai M,

Hayase T, Tamaki N, Ohuchi N. The Correlation Between Ultrasonographic Findings and Pathologic Features in

Breast Disorders. Jpn J Clin Oncol. 40(10):905-912. 2010 （原著）

644. Iino K, Oki Y, Yamashita M, Matsushita F, Hayashi C, Yogo K, Nishizawa S, Yamada S, Maekawa M,

Sasano H, Nakamura H. Possible Relevance between Prohormone Convertase 2 Expression and Tumor

Growth in Human Adrenocorticotropin-Producing Pituitary Adenoma. J Clin Endocrinol Metab. 95(8):4003-4011.

2010 （原著）

645. Yue X, Akahira J, Utsunomiya H, Miki Y, Takahashi N, Niikura H, Ito K, Sasano H, Okamura K, Yaegashi N.

Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer. Pathol Int.

60:400-406. 2010 （原著）

646. Ikoma A, Saito T, Murata M, Toyoshima H, Nakamura Y, Kawakami M, Sasano H, Ishikawa SE. Bilateral

aldosteronoma associated with secondary aldosteronism in a chronic hemodialysis subject. Intern Med.

49(11):1017-1021. 2010 （症例）

647. Vachon CM, Sasano H, Ghosh K, Brandt KR, Watson DA, Reynolds C, Lingle WL, Goss PE, Li R, Aiyar SE,

Scott CG, Pankratz VS, Santen RJ, Ingle JN. Aromatase immunoreactivity is increased in mammographically

dense regions of the breast. Breast Cancer Res Treat. 125(1):243-252. 2011 （原著）

648. Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G,

Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S,

Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G,

Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC. American Society of Clinical Oncology/College of

American Pathologists guideline recommendations for immunohistochemical testing of estrogen and

progesterone receptors in breast cancer. Arch Pathol Lab Med. 134(6):907-922. 2010 （原著）

649. Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, Akahira JI, Ishida T, Watanabe M, Hirakawa H,

Ohuchi N, Sasano H. Nudix-type motif 2 (NUDT2) in human breast carcinoma: A potent prognostic factor

associated with cell proliferation. Int J Cancer. 128(8):1770-1782. 2011 （原著）

650. Tamaki K, Sasano H, Ishida T, Miyashita M, Takeda M, Amari M, Tamaki N, Ohuchi N. Comparison of core

needle biopsy (CNB) and surgical specimens for accurate preoperative evaluation of ER, PgR and HER2 status

of breast cancer patients. Cancer Sci. 101(9):2074-2079. 2010 （原著）

651. Sasaki Y, Miki Y, Hirakawa H, Onodera Y, Takagi K, Akahira JI, Honma S, Ishida T, Watanabe M, Sasano H,

Suzuki T. Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease:

Comparison with normal breast and breast carcinoma. Cancer Sci. 101 (10):2286-2292. 2010 （原著）

652. Iida S, Miki Y, Ono K, Akahira JI, Suzuki T, Ishida K, Watanabe M, Sasano H. Novel classification based on

immunohistochemistry combined with hierarchical clustering analysis in non-functioning neuroendocrine tumor

patients. Cancer Sci. 101(10):2278-2285. 2010 （原著）

653. Moriya T, Kanomata N, Kozuka Y, Hirakawa H, Kimijima I, Kimura M, Watanabe M, Sasano H, Ishida T,

Ohuchi N, Kurebayashi J, Sonoo H. Molecular morphological approach to the pathological study of development

and advancement of human breast cancer. Med Mol Morphol. 43(2):67-73. 2010 （総説）

654. Suzuki T, Miki Y, Takagi K, Hirakawa H, Moriya T, Ohuchi N, Sasano H. Androgens in human breast

carcinoma. Med Mol Morphol. 43(2):75-81. 2010 （総説）

655. Terui K, Sakihara S, Kageyama K, Nigawara T, Takayasu S, Matsuhashi Y, Kon A, Yamamoto H, Ohyama C,

Sasano H, Suda T. A case of adrenocortical oncocytoma occurring with aldosteronoma. J Clin Endocrinol Metab.

95(8):3597-3598. 2010 （症例）

656. Miki Y, Suzuki T, Abe K, Suzuki S, Niikawa H, Iida S, Hata S, Akahira J, Mori K, Evans DB, Kondo T,

Yamada-Okabe H, Sasano H. Intratumoral localization of aromatase and interaction between stromal and

parenchymal cells in the non-small cell lung carcinoma microenvironment. Cancer Res. 70(16):6659-6669.

2010 （原著）

657. Sasano H, Iida S, Kasajima A. Immunohistochemical evaluation of somatostatin receptor subtypes in

surgical pathology specimens of neuroendocrine tumors. Pathologe. Suppl 2:199-203. 2010 （総説）

658. Yamada S, Tanimoto A, Wang KY, Ding Y, Guo X, Shimajiri S, Sasano H, Sasaguri Y. Non-functional

adrenocortical adenoma: A unique case of combination with myelolipoma and endothelial cysts. Pathol Res

Pract. 207(3):192-196. 2011 （症例）

659. Kasajima A, Sers C, Sasano H, Jöhrens K, Stenzinger A, Noske A, Buckendahl AC, Darb-Esfahani S,

Müller BM, Budczies J, Lehman A, Dietel M, Denkert C, Weichert W. Down-regulation of the antigen processing

machinery is linked to a loss of inflammatory response in colorectal cancer. Hum Pathol. 41(12):1758-1769.

2010 （原著）

660. Toi M, Ohashi Y, Seow A, Moriya T, Tse G, Sasano H, Park BW, Chow LW, Laudico AV, Yip CH, Ueno E,

Ishiguro H, Bando H. The Breast Cancer Working Group presentation was divided into three sections: the

epidemiology, pathology and treatment of breast cancer. Jpn J Clin Oncol. 40 Suppl 1:i13-18. 2010 （原著）

661. Tsujimoto T, Takaichi M, Endo H, Yasuda K, Kishimoto M, Noto H, Gomibuchi H, Yasuda H,

Yamamoto-Honda R, Takahashi Y, Kajio H, Sasano H, Noda M. A patient with diabetes and breast cancer in

whom virilization was caused by a testosterone-producing mature cystic teratoma containing a Brenner tumor.

Am J Med Sci. 341:74-77. 2011 （症例）

662. Yiu CC, Chanplakorn N, Chan MS, Loo WT, Chow LW, Toi M, Sasano H. Down-regulation of heat-shock

protein 70 (HSP-70) correlated with responsiveness to neoadjuvant aromatase inhibitor therapy in breast cancer

patients. Anticancer Res. 30(9):3465-3472. 2010 （原著）

663. Onodera Y, Miki Y, Suzuki T, Takagi K, Akahira JI, Sakyu T, Watanabe M, Inoue S, Ishida T, Ohuchi N,

Sasano H. Runx2 in human breast carcinoma: its potential roles in cancer progression. Cancer Sci.

101(12):2670-2675. 2010 （原著）

664. Suzuki T, Miki Y, Nakamura Y, Ito K, Sasano H. Steroid sulfatase and estrogen sulfotransferase in human

carcinomas. Mol Cell Endocrinol. 340(2):148-153. 2011 （総説）

665. Miyashita M, Ishida T, Ishida K, Tamaki K, Amari M, Watanabe M, Ohuchi N, Sasano H. Histopathological

subclassification of triple negative breast cancer using prognostic scoring system: five variables as candidates.

Virchows Arch. 458(1):65-72. 2011 （原著）

666. Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, Rainey WE, Hui XG, Akahira JI,

Nakamura Y, Sasano H, Okamoto H, Ito S, Sugawara A. Peroxisome proliferator-activated receptor-{gamma}

suppresses CYP11B2 expression and aldosterone production. J Mol Endocrinol. 46(1):37-49. 2011 （原著）

667. Ito K, Utsunomiya H, Niikura H, Yaegashi N, Sasano H. Inhibition of estrogen actions in human

gynecological malignancies: New aspects of endocrine therapy for endometrial cancer and ovarian cancer. Mol

Cell Endocrinol. 340(2):161-167. 2010 （総説）

668. Kasajima A, Pavel M, Darb-Esfahani S, Noske A, Stenzinger A, Sasano H, Dietel M, Denkert C, Röcken C,

Wiedenmann B, Weichert W. mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine

tumours. Endocr Relat Cancer. 18(1):181-192. 2011 （原著）

669. Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N, Sato Y. Roles of

intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas. Cancer Sci. 102(2):446-451. 2011 （原著）

670. Nakamura Y, Xing Y, Hui XG, Kurotaki Y, Ono K, Cohen T, Sasano H, Rainey WE. Human adrenal cells that

express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to

adrenal androstenedione production. J Steroid Biochem Mol Biol, 123:122-126, 2011 （原著）

671. Toi M, Saji S, Masuda N, Kuroi K, Sato N, Takei H, Yamamoto Y, Ohno S, Yamashita H, Hisamatsu K, Aogi

K, Iwata H, Takada M, Ueno T, Saji S, Chanplakorn N, Suzuki T, Sasano H. Ki67 index changes, pathological

response and clinical benefits in primary breast cancers patients treated with 24 weeks aromatase inhibition.

Cancer Sci. 102(4):858-865. 2011 （原著）

672. Wang T, Satoh F, Morimoto R, Nakamura Y, Sasano H, Auchus R, Edwards MA, Rainey W. Gene

expression profiles in aldosterone-producing adenomas and adjacent adrenal glands. Eur J Endocrinol.

164(4):613-619. 2011 （原著）

673. Hayakawa E, Yoshimoto T, Hiraishi K, Kato M, Izumiyama H, Sasano H, Hirata Y. A rare Case of

ACTH-independent Macronodular Adrenal Hyperplasia Associated with Aldosterone-producing Adenoma.

Intern Med. 50(3):227-232. 2011 （症例）

674. Ishidoya S, Kaiho Y, Ito A, Morimoto R, Satoh F, Ito S, Ishibashi T, Nakamura Y, Sasano H, Arai Y.

Single-center outcome of laparoscopic unilateral adrenalectomy for patients with primary aldosteronism:

lateralizing disease using results of adrenal venous sampling. Urology. 78(1):68-73. 2011 （原著）

675. Miki Y, Abe K, Suzuki S, Suzuki T, Sasano H. Suppression of estrogen actions in human lung cancer. Mol

Cell Endocrinol. 340(2):168-174. 2011 （総説）

676. Geisler J, Sasano H, Chen S, Purohit A. Steroid Sulfatase Inhibitors: Promising New Tools for Breast

Cancer Therapy? J Steroid Biochem Mol Biol. 125(1-2):39-45. 2011 （総説）

677. Akishima-Fukasawa Y, Yoshihara A, Ishikawa Y, Watanabe N, Hiroi N, Akasaka Y, Sasano H, Ishii T,

Yoshino G. Malignant Adrenal Rest Tumor of the Retroperitoneum Producing Adrenocortical Steroids. Endocr

Pathol. 22(2):112-117. 2011 （症例）

678. Verma MK, Miki Y, Sasano H. Aromatase in human lung carcinoma. Steroids. 76(8):759-764. 2011 （総説）

679. Yoshida M, Hiroi M, Imai T, Kikumori T, Himeno T, Nakamura Y, Sasano H, Yamada M, Murakami Y,

Nakamura S, Oiso Y. A case of ACTH-independent macronodular adrenal hyperplasia associated with multiple

endocrine neoplasia type 1. Endocr J. 58(4):269-277. 2011 （症例）

680. Hashimoto N, Kawamura Y, Nakamura T, Murawaki A, Nishiumi T, Hirota Y, Sakagushi K, Kurahashi T,

Miyake H, Fujisawa M, Sasano H, Takahashi Y. A case of primary aldosteronism caused by multiple

adrenocortical macronodules. Intern Med. 50(6):585-590. 2011 （症例）

681. Toi M, Winer EP, Inamoto T, Benson JR, Forbes JF, Mitsumori M, Robertson JF, Sasano H, von Minckwitz

G, Yamauchi A, Klimberg VS. Identifying Gaps in the Locoregional Management of Early Breast Cancer:

Highlights from the Kyoto Consensus Conference. Ann Surg Oncol. 18(10):2885-2892. 2011 （総説）

682. Yoshida M, Sasano H, Kikumori T, Imai T, Murakami Y, Nakamura S, Ogawa K, Miyata M, Murakami M,

Oiso Y. A case of subclinical Cushing syndrome due to primary pigmented nodular adrenocortical disease

associated with adrenocortical adenoma. Endocrine. 40(1):144-145. 2011 （症例）

683. Takizawa N, Muguruma K, Sasano H. Pheochromocytoma and subclinical Cushing's syndrome with focal

adrenocortical hyperplasia. Int J Urol. 18(7):548-549. 2011 （症例）

684. Hiraishi K, Yoshimoto T, Tsuchiya K, Minami I, Doi M, Izumiyama H, Sasano H, Hirata Y.

Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome. Endocr J.

58(7):543-551. 2011 （原著）

685. Demura M, Wang F, Yoneda T, Karashima S, Mori S, Oe M, Kometani M, Sawamura T, Cheng Y, Maeda Y,

Namiki M, Ino H, Fujino N, Uchiyama K, Tsubokawa T, Yamagishi M, Nakamura Y, Ono K, Sasano H, Demura Y,

Takeda Y. Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B,

Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human

cardiovascular and adrenal tissues. J Hypertens. 29(6): 1185-1895. 2011 （原著）

686. Nakamura Y, Fujishima F, Watanabe M, Taniuchi S, Ishida K, Ishidoya S, Arai Y, Sasano H. A case of

prostatic adenocarcinoma with Paneth cell-like appearance. Pol J Pathol. 62(1): 60-64. 2011 （症例）

687. Nakamura Y, Satoh F, Morimoto R, Kudo M, Takase K, Gomez-Sanchez CE, Honma S, Okuyama M,

Yamashita K, Rainey WE, Sasano H, Ito S. 18-Oxocortisol Measurement in Adrenal Vein Sampling as a

Biomarker for Subclassifying Primary Aldosteronism. J Clin Endocrinol Metab. 96(8): 1272-1278. 2011 （原著）

688. Brown KA, McInnes KJ, Takagi K, Ono K, Hunger NI, Wang L, Sasano H, Simpson ER. LKB1 expression is

inhibited by estradiol-17β in MCF-7 cells. J Steroid Biochem Mol Biol. 127(3-5):439-443. 2011 （原著）

689. Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A, Miyazaki S, Moriya T, Sato A, Satomi




S, Sasano H. Retinoid receptors in human esophageal squamous cell carcinoma: Retinoid X receptor as a

potent prognostic factor. Pathol Int. 61(7):401-408. 2011 （原著）

690. Saito T, Tojo K, Furuta N, Ono K, Sasano H, Utsunomiya K. Feminizing adrenocortical carcinoma with

selective suppression of follicle-stimulating hormone secretion and disorganized steroidogenesis: a case study

and literature review. Intern Med. 50(13):1419-1424. 2011 （症例）

691. Nagasaki S, Nakano Y, Masuda M, Ono K, Miki Y, Shibahara Y, Sasano H. Phosphodiesterase type 9

(PDE9) in the human lower urinary tract: an immunohistochemical study. BJU Int. 109(6):934-940. 2012 （原著）

692. Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, Kakuo S, Fujimura T, Hachiya A, Aiba S, Sasano H.

The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis. Mol Cell Endocrinol.

344(1-2):35-40. 2011 （原著）

693. Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Wang L, Chan MS, Wing L, Yiu CC, Wing-Cheong Chow

L, Sasano H. Increased 5α-Reductase Type 2 Expression in Human Breast Carcinoma following Aromatase

Inhibitor Therapy: The Correlation with Decreased Tumor Cell Proliferation. Horm Cancer. 2(1):73-81. 2011 （原

著）

694. Takada M, Saji S, Masuda N, Kuroi K, Sato N, Takei H, Yamamoto Y, Ohno S, Yamashita H, Hisamatsu K,

Aogi K, Iwata H, Ueno T, Sasano H, Toi M. Relationship between body mass index and preoperative treatment

response to aromatase inhibitor exemestane in postmenopausal patients with primary breast cancer. Breast.

21(1):40-45. 2012 （原著）

695. Verma MK, Miki Y, Sasano H. Sex steroid receptors in human lung diseases. J Steroid Biochem Mol Biol.

127(3-5):216-222. 2011 （総説）

696. Nakamura Y, Fujishima F, Ito S, Ishida K, Sato S, Watanabe M, Tanaka H, Nio M, Sasano H. A case of

cutaneous bronchogenic cyst in the scapular area. Pol J Pathol. 62(2):120-121. 2011 （症例）

697. Ito K, Utsunomiya H, Niikura H, Yaegashi N, Sasano H. Inhibition of estrogen actions in human

gynecological malignancies: new aspects of endocrine therapy for endometrial cancer and ovarian cancer. Mol

Cell Endocrinol. 340(2):161-167. 2011 （原著）

698. Tamaki K, Ishida T, Miyashita M, Amari M, Ohuchi N, Tamaki N, Sasano H.

Correlation between mammographic findings and corresponding histopathology: Potential predictors for

biological characteristics of breast diseases. Cancer Sci. 102(12):2179-2185. 2011 （原著）

699. Tamaki K, Ishida T, Miyashita M, Amari M, Mori N, Ohuchi N, Tamaki N, Sasano H. Multidetector row helical

computed tomography for invasive ductal carcinoma of the breast: Correlation between radiological findings and

the corresponding biological characteristics of patients. Cancer Sci. 103(1):67-72. 2012 （原著）

700. Suzuki S, Takagi K, Miki Y, Onodera Y, Akahira JI, Ebata A, Ishida T, Watanabe M, Sasano H, Suzuki T.

Nucleobindin 2 in human breast carcinoma as a potent prognostic factor. Cancer Sci. 103(1):136-143. 2012 （原

著）

701. Hiroki E, Suzuki F, Akahira JI, Nagase S, Ito K, Sugawara J, Miki Y, Suzuki T, Sasano H, Yaegashi N.

MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma. Int J Cancer.






131(4):395-404. 2012 （原著）

702. Sakurai M, Miki Y, Masuda M, Hata S, Shibahara Y, Hirakawa H, Suzuki T, Sasano H. LIN28: A regulator of

tumor-suppressing activity of let-7 microRNA in human breast cancer. J Steroid Biochem Mol Biol.

131(3-5):101-106. 2012 （原著）

703. Nakamura Y, Orikasa K, Fujishima F, Shibahara Y, Saito R, Ohkubo T, Ueno S, Sasano H. A case of villous

adenoma of the urinary bladder with tubulovillous architecture: characterization by immunohistochemical

analysis. Pol J Pathol. 62(3):179-182. 2011 （症例）

704. Tamaki K, Ishida T, Miyashita M, Amari M, Ohuchi N, Uehara K, Kamada Y, Tamaki N, Sasano H.

Retrospective analysis of mammographic findings for Japanese women: A potential predictor for breast

malignancies. Cancer Sci. 103(3):472-476. 2012 （原著）

705. Nakamura Y, Rege J, Satoh F, Morimoto R, Kennedy MR, Ahlem CN, Honma S, Sasano H, Rainey WE.

Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and

after ACTH stimulation. Clin Endocrinol (Oxf). 76(6):778-784. 2012 （原著）

706. Iida S, Miki Y, Ono K, Akahira J, Nakamura Y, Suzuki T, Sasano H. Synergistic anti-tumor effects of

RAD001 with MEK inhibitors in neuroendocrine tumors: A potential mechanism of therapeutic limitation of

mTOR inhibitor. Mol Cell Endocrinol. 350(1):99-106. 2012 （原著）

707. Tamaki K, Ishida T, Miyashita M, Amari M, Ohuchi N, Kamada Y, Uehara K, Tamaki N, Sasano H. Breast

Ultrasonographic and Histopathological Characteristics Without Any Mammographic Abnormalities. Jpn J Clin

Oncol. 42(3):168-174. 2012 （原著）

708. Knower KC, To SQ, Takagi K, Miki Y, Sasano H, Simpson ER, Clyne CD. Melatonin suppresses aromatase

expression and activity in breast cancer associated fibroblasts. Breast Cancer Res Treat. 132(2):765-771. 2012

（原著）

709. Nagasaki S, Nakamura Y, Maekawa T, Akahira J, Miki Y, Suzuki T, Ishidoya S, Arai Y, Sasano H.

Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by

estrogen receptor βcx in human prostate carcinoma. Neoplasma. 59(2):224-232. 2012 （原著）

710. Satoh H, Saito R, Hisata S, Shiihara J, Taniuchi S, Nakamura Y, Nukiwa T, Ebina M, Sasano H. An ectopic

ACTH-producing small cell lung carcinoma associated with enhanced corticosteroid biosynthesis in the

peritumoral areas of adrenal metastasis. Lung Cancer. 76(3):486-490. 2012 （症例）

711. Delle Fave G, Kwekkeboom DJ, Van Cutsem E, Rindi G, Kos-Kudla B, Knigge U, Sasano H, Tomassetti P,

Salazar R, Ruszniewski P. ENETS Consensus Guidelines for the Management of Patients with Gastroduodenal

Neoplasms. Neuroendocrinology. 95(2):74-87. 2012 （原著）

712. Miki Y, Ono K, Hata S, Suzuki T, Kumamoto H, Sasano H. The advantages of co-culture over mono cell

culture in simulating in vivo environment. J Steroid Biochem Mol Biol. 131(3-5):68-75. 2012 （原著）

713. Chan MS, Wang L, Chanplakorn N, Tamaki K, Ueno T, Toi M, Loo WT, Chow LW, Suzuki T, Sasano H.

Effects of estrogen depletion on angiogenesis in estrogen-receptor-positive breast carcinoma--an

immunohistochemical study of vasohibin-1 and CD31 with correlation to pathobiological response of the

patients in neoadjuvant aromatase inhibitor therapy. Expert Opin Ther Targets. 16 Suppl 1: S69-78. 2012 （原

著）

714. Verma MK, Miki Y, Abe K, Niikawa H, Sasano H. Cytoplasmic estrogen receptor β as a potential marker in

human non-small cell lung carcinoma. Expert Opin Ther Targets. 16 Suppl 1:S91-102. 2012 （原著）

715. Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A,

Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M. Accumulation of

p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. Cancer Sci.

103(4):760-766. 2012 （原著）

716. Kukidome D, Miyamura N, Sakakida K, Shimoda S, Shigematu Y, Nishi K, Yamashita Y, Eto M, Sasano H,

Araki E. A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma: usefulness of

the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome.

Intern Med. 51(4):395-400. 2012 （症例）

717. Inuzuka M, Tamura N, Sone M, Taura D, Sonoyama T, Honda K, Kojima K, Fukuda Y, Ueda Y, Yamashita Y,

Kondo E, Yamada G, Fujii T, Miura M, Kanamoto N, Yasoda A, Arai H, Mikami Y, Sasano H, Nakao K. A case of

myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy. Intern Med.

51(5):479-485. 2012 （症例）

718. Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, Takagi K, Onodera Y, Miki Y, Watanabe M, Ishida

K, Ohnuma S, Sasaki H, Sato R, Karasawa H, Shibata C, Unno M, Sasaki I, Sasano H. Runt-related

transcription factor 2 in human colon carcinoma: A potent prognostic factor associated with estrogen receptor.

Int J Cancer. 131(10):2284-2293. 2012 （原著）

719. Shibahara Y, Miki Y, Onodera Y, Hata S, Chan MS, Yiu CC, Loo TY, Nakamura Y, Akahira JI, Ishida T, Abe K,

Hirakawa H, Chow LW, Suzuki T, Ouchi N, Sasano H. Aromatase inhibitor treatment of breast cancer cells

increases the expression of let-7f, a microRNA targeting CYP19A1. J Pathol. 227(3):357-366. 2012 （原著）

720. Zuguchi M, Miki Y, Onodera Y, Fujishima F, Takeyama D, Okamoto H, Miyata G, Sato A, Satomi S, Sasano

H. Estrogen receptor α and β in esophageal squamous cell carcinoma. Cancer Sci. 103(7):1348-1355. 2012 （原

著）

721. Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, Kakuo S, Fujimura T, Hachiya A, Honma S, Aiba S,

Sasano H. Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute

regulatory protein in the homeostasis of human skin. Mol Cell Endocrinol. 362(1-2):19-28. 2012 （原著）

722. Takada M, Sugimoto M, Ohno S, Kuroi K, Sato N, Bando H, Masuda N, Iwata H, Kondo M, Sasano H,

Chow LW, Inamoto T, Naito Y, Tomita M, Toi M. Predictions of the pathological response to neoadjuvant

chemotherapy in patients with primary breast cancer using a data mining technique. Breast Cancer Res Treat.

134(2):661-670. 2012 （原著）

723. Takada M, Sugimoto M, Naito Y, Moon HG, Han W, Noh DY, Kondo M, Kuroi K, Sasano H, Inamoto T,

Tomita M, Toi M. Prediction of axillary lymph node metastasis in primary breast cancer patients using a decision

treebased model. BMC Med Inform Decis Mak. 12:54. 2012 （原著）

724. Geisler J, Sasano H. Special issue on steroids and cancer. Preface. J Steroid Biochem Mol Biol.



131(3-5):67. 2012 （総説）

725. Tamaki K, Ishida T, Tamaki N, Kamada Y, Uehara K, Miyashita M, Amari M, Tadano-Sato A, Takahashi Y,

Watanabe M, McNamara K, Ohuchi N, Sasano H. Analysis of clinically relevant values of Ki-67 labeling index in

Japanese breast cancer patients. Breast Cancer. 21(3):325-33. 2014 （原著）

726. Brutsaert EF, Sasano H, Unger P, Beasley MB, Golden BK, Inabnet WB, Levine AC. Adrenal cortical

carcinoma with late pulmonary metastases causing clinical Cushing's Syndrome: Case study with

immunohistochemical analysis of steroidogenic enzyme production. Endocr Pract. 18(6):e138-143. 2012 （症

例）

727. Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Miki Y, Kamogawa Y, Yamamoto K, Takayuki 2nd, Egawa

S, Unno M, Sasano H. Aromatase in colon carcinoma. Anticancer Res. 32(8):3069-3075. 2012 （原著）

728. Stebbing J, Filipovic A, Lit LC, Blighe K, Grothey A, Xu Y, Miki Y, Chow LW, Coombes RC, Sasano H, Shaw

JA, Giamas G. LMTK3 is implicated in endocrine resistance via multiple signaling pathways. Oncogene.

32(28):3371-3380. 2012 （原著）

729. Iwata M, Oki Y, Okazawa T, Ishizawa S, Taka C, Yamazaki K, Tobe K, Fukuoka J, Sasano H, Nishikawa T.

A Rare Case of Adrenocorticotropic Hormone (ACTH)-independent Macroadrenal Hyperplasia Showing Ectopic

Production of ACTH. Intern Med. 51(16):2181-2187. 2012 （症例）

730. To SQ, Takagi K, Miki Y, Suzuki K, Abe E, Yang Y, Sasano H, Simpson ER, Knower KC, Clyne CD.

Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer. J Steroid Biochem Mol Biol.

132(3-5):331-338. 2012 （原著）

731. Takagi K, Miki Y, Onodera Y, Nakamura Y, Ishida T, Watanabe M, Inoue S, Sasano H, Suzuki T.

Kruppel-like factor 5 in human breast carcinoma: a potent prognostic factor induced by androgens. Endocr Relat

Cancer. 19(6):741-750. 2012 （原著）

732. McNamara KM, Nakamura Y, Sasano H, Handelsman DJ, Simanainen U. Prostate epithelial AR

inactivation leads to increased intraprostatic androgen synthesis. Prostate. 73(3):316-327. 2013（原著）

733. McNamara K, Yoda T, Takagi K, Miki Y, Suzuki T, Sasano H. Androgen receptor in triple negative breast

cancer. J Steroid Biochem Mol Biol. 133:66-76. 2012 （総説）

734. Verma MK, Miki Y, Abe K, Nagasaki S, Niikawa H, Suzuki S, Kondo T, Sasano H. Co-expression of

estrogen receptor beta and aromatase in Japanese lung cancer patients: Gender-dependent clinical outcome.

Life Sci. 91(15-16):800-808. 2012 （原著）

735. Saito R, Kasajima A, Taniuchi S, Fujishima F, Ishida K, Nakamura Y, Yamanda S, Takahashi T, Hitomi H,

Murakami K, Watanabe M, Sasano H. Case studys of primary pulmonary adenocarcinoma with pleural spread:

so-called pseudomesotheliomatous adenocarcinoma. Pathol Int. 62(10):709-715. 2012 （症例）

736. Nakamura Y, Felizola SJ, Kurotaki Y, Fujishima F, McNamara KM, Suzuki T, Arai Y, Sasano H. Cyclin D1

(CCND1) expression is involved in estrogen receptor beta (ERβ) in human prostate cancer. Prostate.

73(6):590-595. 2013 （原著）





737. Takagi K, Moriya T, Kurosumi M, Oka K, Miki Y, Ebata A, Toshima T, Tsunekawa S, Takei H, Hirakawa H,

Ishida T, Hayashi SI, Kurebayashi J, Sasano H, Suzuki T. Intratumoral Estrogen Concentration and Expression

of Estrogen-Induced Genes in Male Breast Carcinoma: Comparison with Female Breast Carcinoma. Horm

Cancer. 4(1):1-11. 2012 （原著）

738. Kobayashi M, Miki Y, Ebina M, Abe K, Mori K, Narumi S, Suzuki T, Sato I, Maemondo M, Endo C, Inoue A,

Kumamoto H, Kondo T, Yamada-Okabe H, Nukiwa T, Sasano H. Carcinoembryonic antigen-related cell

adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma. Br J

Cancer. 107(10):1745-1753. 2012 （原著）

739. Felizola SJ, Nakamura Y, Hui XG, Satoh F, Morimoto R, M McNamara K, Midorikawa S, Suzuki S, Rainey

WE, Sasano H. Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: Involvement in

development and oncogenesis. Mol Cell Endocrinol. 365(2):207-211. 2013 （原著）

740. Toi M, Benson JR, Winer EP, Forbes JF, von Minckwitz G, Golshan M, Robertson JF, Sasano H, Cole BF,

Chow LW, Pegram MD, Han W, Huang CS, Ikeda T, Kanao S, Lee ES, Noguchi S, Ohno S, Partridge AH,

Rouzier R, Tozaki M, Sugie T, Yamauchi A, Inamoto T. Preoperative systemic therapy in locoregional

management of early breast cancer: highlights from the Kyoto Breast Cancer Consensus Conference. Breast

Cancer Res Treat. 136(3):919-926. 2012 （原著）

741. Mise K, Ubara Y, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J,

Sawa N, Hashimoto M, Fujii T, Sasano H, Takaichi K. Cushing's Syndrome after Hemodialysis for 21 Years. J

Clin Endocrinol Metab. 98(1):13-19. 2013 （症例）

742. Katoh T, Yasuda M, Hasegawa K, Kozawa E, Maniwa J, Sasano H. Estrogen-producing endometrioid

adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.

Diagn Pathol. 7:164. 2012 （原著）

743. Masuda M, Miki Y, Hata S, Takagi K, Sakurai M, Ono K, Suzuki K, Yang Y, Abe E, Hirakawa H, Ishida T,

Suzuki T, Ohuchi N, Sasano H. An induction of microRNA, miR-7 through estrogen treatment in breast

carcinoma. J Transl Med. 10 Suppl 1:S2. 2012 （原著）

744. Sakuma I, Suematsu S, Matsuzawa Y, Saito J, Omura M, Maekawa T, Nakamura Y, Sasano H, Nishikawa

T. Characterization of steroidogenic enzyme expression in aldosterone-producing adenoma: a comparison with

various human adrenal tumors. Endocr J. 60(3):329-336. 2013 （原著）

745. Arai S, Shibata Y, Nakamura Y, Kashiwagi B, Uei T, Tomaru Y, Miyashiro Y, Honma S, Hashimoto K, Sekine

Y, Ito K, Sasano H, Suzuki K. Development of prostate cancer in a patient with primary hypogonadism:

intratumoural steroidogenesis in prostate cancer tissues. Andrology. 1(1):169-174. 2013 （症例）

746. Tamaki K, Tamaki N, Kamada Y, Uehara K, Ohuchi N, Miyashita M, Ishida T, Sasano H. Clinical

Significance Following Breast Conservation Therapy with or without Irradiation in Breast Cancer Patients. Jpn J

Clin Oncol. 43(3):251-257. 2013 （原著）

747. Chan MS, Wang L, Felizola SJ, Ueno T, Toi M, Loo W, Chow LW, Suzuki T, Sasano H. Changes of tumor

infiltrating lymphocyte subtypes before and after neoadjuvant endocrine therapy in estrogen receptor-positive

breast cancer patients - an immunohistochemical study of cd8+ and foxp3+ using double immunostaining with

correlation to the pathobiological response of the patients. Int J Biol Markers. 27(4):e295-304. 2012 （原著）










748. Takagi K, Miki Y, Shibahara Y, Nakamura Y, Ebata A, Watanabe M, Ishida T, Sasano H, Suzuki T. BUB1

Immunolocalization in Breast Carcinoma: Its Nuclear Localization as a Potent Prognostic Factor of the Patients.

Horm Cancer. 4(2):92-102. 2013 （原著）

749. Nakamura Y, McNamara K, Sasano H. Estrogen receptor expression and its relevant signaling pathway in

prostate cancer: a target of therapy. Curr Mol Pharmacol. 2013 Jan 8. [Epub ahead of print] （総説）

750. Okamoto H, Fujishima F, Ishida K, Tsuchida K, Shimizu T, Goto H, Sato A, Satomi S, Sasano H. Intraductal

papillary mucinous neoplasm originating from a jejunal heterotopic pancreas: report of a case. Surg Today.

44(2):349-353. 2014 （症例）

751. Shibahara Y, Miki Y, Ishida T, Nakamura Y, Suzuki T, Ohuchi N, Sasano H. Immunohistochemical analysis

of aromatase in metastatic lymph nodes of breast cancer. Pathol Int. 63(1):20-28. 2013 （原著）

752. Chan M, Wang L, Chanplakorn N, Tamaki K, Ueno T, Toi M, Loo W, Chow LW, Suzuki T, Sasano H.

Author's response. Expert Opin Ther Targets. 17(1):106. 2013 （解説）

753. McNamara K, Yoda T, Miki Y, Chanplakorn N, Wongwaisayawan S, Incharoen P, Kongdan Y, Wang L,

Takagi K, Mayu T, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Tamaki K, Ishida T, Ohuchi N, Sasano H.

Androgenic pathway in triple negative invasive ductal tumours: its correlation with tumour cell proliferation.

Cancer Sci. 104(5):639-646. 2013 （原著）

754. Fujimoto K, Honjo S, Tatsuoka H, Hamamoto Y, Kawasaki Y, Matsuoka A, Ikeda H, Wada Y, Sasano H,

Koshiyama H. Primary aldosteronism associated with subclinical Cushing syndrome. J Endocrinol Invest.

36(8):564-567. 2013 （症例）

755. Rege J, Nakamura Y, Satoh F, Morimoto R, Kennedy MR, Layman LC, Honma S, Sasano H, Rainey WE.

Liquid Chromatography-Tandem Mass Spectrometry Analysis of Human Adrenal Vein 19-Carbon Steroids

Before and After ACTH Stimulation. J Clin Endocrinol Metab. 98(3):1182-1188. 2013 （原著）

756. Yue X, Utsunomiya H, Akahira JI, Suzuki F, Ito K, Nagase S, Sasano H, Yaegashi N. Expression of steroid

and xenobiotic receptor in uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma. Oncol

Lett. 5(3):835-839. 2013 （原著）

757. Okamoto H, Fujishima F, Nakamura Y, Zuguchi M, Ozawa Y, Takahashi Y, Miyata G, Kamei T, Nakano T,

Taniyama Y, Teshima J, Watanabe M, Sato A, Ohuchi N, Sasano H. Significance of CD133 expression in

esophageal squamous cell carcinoma. World J Surg Oncol. 11:51. 2013 （原著）

758. Yoshikawa T, Naganuma F, Iida T, Nakamura T, Harada R, Mohsen AS, Kasajima A, Sasano H, Yanai K.

Molecular mechanism of histamine clearance by primary human astrocytes. Glia. 61(6):905-916. 2013 （原著）

759. Yazdani S, Miki Y, Tamaki K, Ono K, Iwabuchi E, Abe K, Suzuki T, Sato Y, Kondo T, Sasano H. Proliferation

and maturation of intratumoral blood vessels in non-small cell lung cancer. Hum Pathol. 44(8):1586-1596. 2013

（原著）

760. Iida S, Kakinuma H, Miki Y, Abe K, Sakurai M, Suzuki S, Niikawa H, Akahira J, Suzuki T, Sasano H. Steroid

sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma. Br J Cancer.















108(7):1415-1424. 2013 （原著）

761. Murakami K, Watanabe M, Nakashima N, Fujimori K, Ishida K, Ohuchi N, Sasano H. Water-clear cell

adenoma associated with primary hyperparathyroidism: report of a case. Surg Today. 44(4):773-777. 2014 （症

例）

762. Okamoto H, Fujishima F, Nakamura Y, Zuguchi M, Miyata G, Kamei T, Nakano T, Katsura K, Abe S,

Taniyama Y, Teshima J, Watanabe M, Sato A, Ohuchi N, Sasano H. Murine double minute 2 and its association

with chemoradioresistance of esophageal squamous cell carcinoma. Anticancer Res. 33(4):1463-1471. 2013

（原著）

763. Samarajeewa NU, Yang F, Docanto MM, Sakurai M, McNamara KM, Sasano H, Fox SB, Simpson ER,

Brown KA. HIF-1alpha stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma.

Breast Cancer Res. 15(2):R30. 2013 （原著）

764. Yokoyama H, Adachi T, Tsubouchi K, Tanaka M, Sasano H. Non-functioning Adrenocortical Carcinoma

Arising in an Adrenal Rest: Immunohistochemical Study of an Adult Patient. Tohoku J Exp Med. 229(4):267-270.

2013 （症例報告）

765. Miyata M, Yoshida M, Shinoda J, Sasano H, Oiso Y. A Marked Difference in the Vasopressin

Responsiveness Between the Adrenal Glands in a Patient with Adrenocorticotropin-independent Macronodular

Adrenal Hyperplasia. Intern Med. 52(10):1073-1078. 2013 （症例）

766. Iwata H, Masuda N, Ohno S, Rai Y, Sato Y, Ohsumi S, Hashigaki S, Nishizawa Y, Hiraoka M, Morimoto T,

Sasano H, Saeki T, Noguchi S. A randomized, double-blind, controlled study of exemestane versus anastrozole

for the first-line treatment of postmenopausal Japanese women with hormone-receptor-positive advanced

breast cancer. Breast Cancer Res Treat. 139(2):441-451. 2013 （原著）

767. Takagi K, Ishida T, Miki Y, Hirakawa H, Kakugawa Y, Amano G, Ebata A, Mori N, Nakamura Y, Watanabe M,

Amari M, Ohuchi N, Sasano H, Suzuki T. Intratumoral concentration of estrogens and clinicopathological

changes in ductal carcinoma in situ following aromatase inhibitor letrozole treatment. Br J Cancer.

109(1):100-108. 2013 （原著）

768. Sato-Tadano A, Suzuki T, Amari M, Takagi K, Miki Y, Tamaki K, Watanabe M, Ishida T, Sasano H, Ohuchi N.

Hexokinase II in breast carcinoma: a potent prognostic factor associated with hypoxia-inducible factor 1α and

Ki-67. Cancer Sci. 104(10):1380-1388. 2013 （原著）

769. Takagi K, Ito S, Miyazaki T, Miki Y, Shibahara Y, Ishida T, Watanabe M, Inoue S, Sasano H, Suzuki T.

Amyloid precursor protein (APP) in human breast cancer: an androgen-induced gene associated with cell

proliferation. Cancer Sci. 104(11):1532-1538. 2013 （原著）

770. Mikami Y, Ueno T, Yoshimura K, Tsuda H, Kurosumi M, Masuda S, Horii R, Toi M, Sasano H. Inter-observer

concordance of Ki67 labeling index in breast cancer: Japan Breast Cancer Research Group (JBCRG) Ki67 Ring

Study. Cancer Sci. 104(11):1539-1543. 2013 （原著）

771. Tamaki K, Tamaki N, Kamada Y, Uehara K, Miyashita M, Ishida T, Sasano H. A Non-invasive Modality: The

US Virtual Touch Tissue Quantification (VTTQ) for Evaluation of Breast Cancer. Jpn J Clin Oncol. 43(9):889-895.

2013 （原著）

772. Hata S, Miki Y, Saito R, Ishida K, Watanabe M, Sasano H. Aromatase in human liver and its diseases.

Cancer Med. 2(3):305-315. 2013 （原著）

773. Shibahara Y, Miki Y, Sakurada C, Uchida K, Hata S, McNamara K, Yoda T, Takagi K, Nakamura Y, Suzuki T,

Ishida T, Ohuchi N, Sasano H. Androgen and androgen-metabolizing enzymes in metastasized lymph nodes of

breast cancer. Hum Pathol. 44(10):2338-2345. 2013（原著）

774. Chen SF, Kasajima A, Yazdani S, Chan MS, Wang L, He YY, Gao HW, Sasano H. Clinicopathologic

significance of immunostaining of α-thalassemia/mental retardation syndrome X-linked protein and death

domain-associated protein in neuroendocrine tumors. Hum Pathol. 44(10):2199-2203. 2013 （原著）

775. McNamara KM, Nakamura Y, Miki Y, Sasano H. Phase Two Steroid Metabolism and Its Roles in Breast and

Prostate Cancer Patients. Front Endocrinol (Lausanne). 4:116. 2013 （総説）

776. Ichikawa K, Fujimori T, Moriya T, Ochiai A, Yoshinaga S, Kushima R, Nagahama R, Ohkura Y, Tanaka S,

Ajioka Y, Hirata I, Tanaka M, Hoshihara Y, Kinoshita Y, Sasano H, Iwashita A, Tomita S, Hirota S, Yao T, Fujii S,

Matsuda T, Ueno H, Ishikawa Y, Takubo K, Fukushima N, Sugai T, Iwafuchi M, Imura J, Manabe T, Fukayama M.

Digestive Disease Management in Japan: A Report on The 6th Diagnostic Pathology Summer Fest in 2012.

Digestion. 88(3):153-160. 2013（総説）

777. Miyake Y, Tanaka K, Nishikawa T, Naruse M, Takayanagi R, Sasano H, Takeda Y, Shibata H, Sone M,

Satoh F, Yamada M, Ueshiba H, Katabami T, Iwasaki Y, Tanaka H, Tanahashi Y, Suzuki S, Hasegawa T,

Katsumata N, Tajima T, Yanase T. Prognosis of primary aldosteronism in Japan: results from a nationwide

epidemiological study. Endocr J. 61(1):35-40. 2014 （原著）

778. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H,

Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant

adrenocortical neoplasm producing testosterone and cortisol. Tohoku J Exp Med.231(2):75-84. 2013 （症例）

779. Saito R, Miki Y, Hata S, Takagi K, Iida S, Oba Y, Ono K, Ishida T, Suzuki T, Ohuchi N, Sasano H. Aryl

Hydrocarbon Receptor in Breast Cancer-A Newly Defined Prognostic Marker. Horm Cancer. 5(1):11-21. 2014

（原著）

780. Felizola SJ, Nakamura Y, Satoh F, Morimoto R, Kikuchi K, Nakamura T, Hozawa A, Wang L, Onodera Y, Ise

K, McNamara KM, Midorikawa S, Suzuki S, Sasano H. Glutamate receptors and the regulation of

steroidogenesis in the human adrenal gland: The metabotropic pathway. Mol Cell Endocrinol. 382(1):170-177.

2014 （原著）

781. Ueno T, Masuda N, Yamanaka T, Saji S, Kuroi K, Sato N, Takei H, Yamamoto Y, Ohno S, Yamashita H,

Hisamatsu K, Aogi K, Iwata H, Sasano H, Toi M. Evaluating the 21-gene assay Recurrence Score® as a

predictor of clinical response to 24 weeks of neoadjuvant exemestane in estrogen receptor-positive breast

cancer. Int J Clin Oncol. 19(4):607-613. 2014 （原著）

782. Nakamura T, Yoshikawa T, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K. The Expression and

Function of Histamine H3 Receptor in Pancreatic β-cells. Br J Pharmacol. 171(1):171-185. 2014 （原著）

783. Ohno S, Chow LW, Sato N, Masuda N, Sasano H, Takahashi F, Bando H, Iwata H, Morimoto T, Kamigaki S,

















Nakayama T, Nakamura S, Kuroi K, Aogi K, Kashiwaba M, Yamashita H, Hisamatsu K, Ito Y, Yamamoto Y, Ueno

T, Fakhrejahani E, Yoshida N, Toi M. Randomized trial of preoperative docetaxel with or without capecitabine

after 4 cycles of 5-fluorouracil-epirubicin-cyclophosphamide (FEC) in early-stage breast cancer: exploratory

analyses identify Ki67 as a predictive biomarker for response to neoadjuvant chemotherapy. Breast Cancer Res

Treat. 142(1):69-80. 2013 （原著）

784. Knower KC, Chand AL, Eriksson N, Takagi K, Miki Y, Sasano H, Visvader JE, Lindeman GJ, Funder JW,

Fuller PJ, Simpson ER, Tilley WD, Leedman PJ, Graham JD, Muscat GE, Clarke CL, Clyne CD. Distinct nuclear

receptor expression in stroma adjacent to breast tumors. Breast Cancer Res Treat. 142(1):211-223. 2013 （原

著）

785. Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K,

Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. Dynamic CCAAT/Enhancer Binding

Protein-Associated Changes of DNA Methylation in the Angiotensinogen Gene. Hypertension. 63(2):281-288.

2014 （原著）

786. Suzuki F, Nagase S, Suzuki K, Oba E, Hiroki E, Matsuda Y, Akahira J, Nishigori H, Sugiyama T, Otsuki T,

Yoshinaga K, Takano T, Niikura H, Ito K, Sasano H, Yaegashi N. Decreased expression of 14-3-3σ is predictive

of poor prognosis for patients with human uterine papillary serous carcinoma. Tohoku J Exp Med.

231(3):193-199. 2013 （原著）

787. Tamaki K, Tamaki N, Kamada Y, Uehara K, Miyashita M, Sm Chan M, Ishida T, Ohuchi N, Sasano H.

Non-invasive evaluation of axillary lymph node status in breast cancer patients using shear wave elastography.

Tohoku J Exp Med. 231(3):211-216. 2013 （原著）

788. Nakano K, Miki Y, Hata S, Ebata A, Takagi K, McNamara KM, Sakurai M, Masuda M, Hirakawa H, Ishida T,

Suzuki T, Ohuchi N, Sasano H. Identification of Androgen-responsive microRNAs and Androgen-related Genes

in Breast Cancer. Anticancer Res. 33(11):4811-4819. 2013 （原著）

789. Nakamura Y, Nishimura M, Terano T, M McNamara K, Sasano H, Kurosu A, Joh K. A Patient with POEMS

Syndrome: The Pathology of Glomerular Microangiopathy. Tohoku J Exp Med. 231(3):229-234. 2013 （症例）

790. Felizola SJ, Nakamura Y, Arata Y, Ise K, Satoh F, Rainey WE, Midorikawa S, Suzuki S, Sasano H.

Metallothionein-3 (MT-3) in the Human Adrenal Cortex and its Disorders. Endocr Pathol. 25(3):229-235. 2014

（原著）

791. Pilon C, Urbanet R, Williams TA, Maekawa T, Vettore S, Sirianni R, Pezzi V, Mulatero P, Fassina A, Sasano

H, Fallo F. 1α,25-Dihydroxyvitamin D3 inhibits the human H295R cell proliferation by cell cycle arrest: A model

for a protective role of vitamin D receptor against adrenocortical cancer. J Steroid Biochem Mol Biol. 140:26-33.

2014 （原著）

792. Iwakura Y, Morimoto R, Kudo M, Ono Y, Takase K, Seiji K, Arai Y, Nakamura Y, Sasano H, Ito S, Satoh F.

Predictors of decreasing glomerular filtration rate and prevalence of chronic kidney disease after treatment of

primary aldosteronism: Renal outcome of 213 cases. J Clin Endocrinol Metab. 99(5):1593-1598. 2014 （原著）

793. Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H,

Yamamoto M, Suzuki T. NRF2 immunolocalization in human breast cancer patients as a prognostic factor.

Endocr Relat Cancer. 21(2):241-252. 2014 （原著）






794. Gomez-Sanchez CE, Qi X, Velarde-Miranda C, Plonczynski MW, Parker CR, Rainey W, Satoh F, Maekawa

T, Nakamura Y, Sasano H, Gomez-Sanchez EP. Development of monoclonal antibodies against human

CYP11B1 and CYP11B2. Mol Cell Endocrinol. 383(1-2):111-117. 2013 （原著）

795. Konosu-Fukaya S, Nakamura Y, Fujishima F, Kasajima A, Takahashi Y, Joh K, Ikeda Y, Ioritani N,

Watanabe M, Sasano H. Bilateral papillary renal cell carcinoma and angiomyolipoma in the patients with

autosomal dominant polycystic kidney disease: case study of two cases and literature review. Pol J Pathol.

64(4):303-307. 2013 （症例）

796. Kobayashi M, Sakakibara T, Inoue A, Fukuhara T, Sasano H, Ichinose M, Nukiwa T. An effective

enrichment strategy for EML4-ALK fusion gene screening in patients with non-small cell lung cancer. Respir

Investig. 52(1):49-56. 2014 （原著）

797. Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A,

Hattangady N, Rainey WE, Satoh F, Sasano H. PCP4: a regulator of aldosterone synthesis in human

adrenocortical tissues. J Mol Endocrinol. 52(2):159-167. 2014 （原著）

798. Rege J, Nakamura Y, Wang T, Merchen TD, Sasano H, Rainey WE. Transcriptome profiling reveals

differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis. J Clin

Endocrinol Metab. 99(3):E518-527. 2014 （原著）

799. Doi M, Satoh F, Maekawa T, Nakamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase

K, Ito S, Sasano H, Okamura H. Isoform-specific monoclonal antibodies against 3β-hydroxysteroid

dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism. J Clin

Endocrinol Metab. 99(2):E257-262. 2014 （原著）

800. Murakami K, Kasajima A, Kawagishi N, Sekiguchi S, Fujishima F, Watanabe M, Sato Y, Ohuchi N, Sasano

H. The prognostic significance of vasohibin 1-associated angiogenesis in patients with hepatocellular carcinoma.

Hum Pathol. 45(3):589-597. 2014 （原著）

801. Dong Y, Yu JJ, Shibahara Y, Lu HS, He HY, Liu JD, Chen SF, Wang L, Zhang Y, Felizola SJ, Chan MS, Ono

K, Ishida T, Ohuchi N, Sasano H. Intercellular adhesion molecule 1/2 and E-selectin in plasma cell mastitis:

immunohistochemical study of 35 cases. Hum Pathol. 45(3):606-610. 2014 （原著）

802. Nakamura Y, Hattangady NG, Ye P, Satoh F, Morimoto R, Ito-Saito T, Sugawara A, Ohba K, Takahashi K,

Rainey WE, Sasano H. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its

regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma

(APA). Mol Cell Endocrinol. 384(1-2):102-108. 2014 （原著）

803. Ito T, Igarashi H, Nakamura K, Sasano H, Okusaka T, Takano K, Komoto I, Tanaka M, Imamura M, Jensen

RT, Takayanagi R, Shimatsu A. Epidemiological trends of pancreatic and gastrointestinal neuroendocrine

tumors in Japan: a nationwide survey analysis. J Gastroenterol. 50(1):58-64. 2015 （原著）

804. Nakamura Y, Kurotaki Y, Ise K, Felizola SJ, McNamara KM, Sasano H. GATA6, SF1, NGFIB and DAX1 in

the remodeled subcapsular zones in primary aldosteronism. Endocr J. 61(4):393-401. 2014 （原著）

805. Takagi K, Ito S, Miyazaki T, Miki Y, Shibahara Y, Ishida T, Watanabe M, Inoue S, Sasano H, Suzuki T.

Amyloid precursor protein (APP) is an androgen-induced gene associated with cell proliferation in human breast

cancer. Cancer Sci. 104(11):1532-1538. 2013 （原著）

806. Yoon V, Heyliger A, Maekawa T, Sasano H, Carrick K, Woodruff S, Rabaglia J, Auchus RJ, Ghayee HK.

Benign adrenal adenomas secreting excess mineralocorticoids and glucocorticoids. Endocrinol Diabetes Metab

Case Rep. 2013; 2013: 130042. doi: 10.1530/EDM-13-0042. Epub 2013 Sep 23. （症例）

807. Nihira K, Miki Y, Ono K, Suzuki T, Sasano H. An inhibition of p62/SQSTM1 caused autophagic cell death of

several human carcinoma cells. Cancer Sci. 105(5):568-575. 2014 （原著）

808. Nishikawa T, Iwata M, Sasano H. Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia.

N Engl J Med. 370(11):1071. 2014 （解説）

809. Zhang Y, Wang P, Shi M, Sasano H, Chan MS, Dai J, Guo L, Liu M, Wang X, Ma Y, Wang L. The pattern of

proline, glutamic acid, and leucine-rich protein 1 expression in Chinese women with primary breast cancer. Int J

Biol Markers. 29(1):e1-7. 2014 （原著）

810. Abe E, Suzuki K, Hayashi N, Yang Y, Chih-Ping L, Uno M, Akiyama F, Yamauchi H, Nakamura S, Tsugawa

K, Tsunoda H, Ohde S, Sasano H. Clinicopathological significance of 'atypical ductal proliferation' in core needle

biopsy of the breast. Pathol Int. 64(2):58-66. 2014 （原著）

811. Yazdani S, Kasajima A, Tamaki K, Nakamura Y, Fujishima F, Ohtsuka H, Motoi F, Unno M, Watanabe M,

Sato Y, Sasano H. Angiogenesis and vascular maturation in neuroendocrine tumors. Hum Pathol.

45(4):866-874. 2014 （原著）

812. Takada M, Ishiguro H, Nagai S, Ohtani S, Kawabata H, Yanagita Y, Hozumi Y, Shimizu C, Takao S, Sato N,

Kosaka Y, Sagara Y, Iwata H, Ohno S, Kuroi K, Masuda N, Yamashiro H, Sugimoto M, Kondo M, Naito Y,

Sasano H, Inamoto T, Morita S, Toi M. Survival of HER2-positive primary breast cancer patients treated by

neoadjuvant chemotherapy plus trastuzumab: a multicenter retrospective observational study (JBCRG-C03

study). Breast Cancer Res Treat. 145(1):143-153. 2014 （原著）

813. Nihira K, Miki Y, Iida S, Narumi S, Ono K, Iwabuchi E, Ise K, Mori K, Saito M, Ebina M, Sato I, Maemondo

M, Yamada-Okabe H, Kondo T, Sasano H. An activation of LC3A-mediated autophagy contributes to de novo

and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma. J Pathol. 234(2):277-288.

2014 （原著）

814. Iida S, Miki Y, Suzuki T, Mori K, Saito M, Niikawa H, Kondo T, Yamada-Okabe H, Sasano H. Activation of

AXL and Antitumor Effects of a Monoclonal Antibody to AXL in Lung Adenocarcinoma. Anticancer Res.

34(4):1821-1827. 2014 （原著）

815. Konosu-Fukaya S, Nakamura Y, Fujishima F, Kasajima A, McNamara KM, Takahashi Y, Joh K, Saito H,

Ioritani N, Ikeda Y, Arai Y, Watanabe M, Sasano H. Renal epithelioid angiomyolipoma with malignant features:

Histological evaluation and novel immunohistochemical findings. Pathol Int. 64(3):133-141. 2014 （原著）

816. McNamara KM, Yoda T, Nurani AM, Shibahara Y, Miki Y, Wang L, Nakamura Y, Suzuki K, Yang Y, Abe E,

Hirakawa H, Suzuki T, Nemoto N, Miyashita M, Tamaki K, Ishida T, Brown KA, Ohuchi N, Sasano H. Androgenic

pathways in the progression of triple-negative breast carcinoma: a comparison between aggressive and

non-aggressive subtypes. Breast Cancer Res Treat. 145(2):281-289. 2014 （原著）










817. Kasajima A, Nakamura Y, Adachi Y, Takahashi Y, Fujishima F, Chiba Y, Uehara S, Watanabe M, Sasano H.

Oncocytic adrenocortical neoplasm arising from adrenal rest in the broad ligament of the uterus. Pathol Int.

64(4):183-188. 2014 （症例）

818. McNamara KM, Sasano H. The intracrinology of breast cancer. J Steroid Biochem Mol Biol. 145:172-178.

2015 （総説）

819. Ohba K, Suzuki T, Nishiyama H, Kaneko K, Hirose T, Totsune K, Sasano H, Takahashi K. Expression of

(pro)renin receptor in breast cancers and its effect on cancercell proliferation. Biomed Res. 35(2):117-126. 2014

（原著）

820. Murakami K, Kawagishi N, Ishida K, Sekiguchi S, Fujishima F, Sasano H, Ohuchi N. Fibrosing Cholestatic

Hepatitis Developing within One Month after Living Donor Liver Transplantation for Chronic Hepatitis C-related

Cirrhosis: A Case study. Transplant Proc. 46(3):995-998. 2014 （症例）

821. Chan MS, Chen SF, Felizola SJ, Wang L, Nemoto N, Tamaki K, Ishida T, Chow LW, Ohuchi N, Sasano H.

Correlation of tumor-infiltrative lymphocyte subtypes alteration with neoangiogenesis before and after

neoadjuvant chemotherapy treatment in breast cancer patients. Int J Biol Markers. 29(3):e193-203. 2014 （原

著）

822. Nakamura Y, Fujishima F, Hui XG, Felizola SJ, Shibahara Y, Akahira JI, McNamara KM, Rainey WE,

Sasano H. 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. Endocr

Res. 40(1):8-13. 2014 （原著）

823. Nakamura Y, Maekawa T, Felizola SJ, Satoh F, Qi X, Velarde-Miranda C, Plonczynski MW, Ise K, Kikuchi K,

Rainey WE, Gomez-Sanchez EP, Gomez-Sanchez CE, Sasano H. Adrenal CYP11B1/2 expression in primary

aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies. Mol Cell Endocrinol.

392(1-2):73-79. 2014 （原著）

824. Ono Y, Nakamura Y, Maekawa T, Felizola SJ, Morimoto R, Iwakura Y, Kudo M, Seiji K, Takase K, Arai Y,

Gomez-Sanchez CE, Ito S, Sasano H, Satoh F. Different Expression of 11β-Hydroxylase and Aldosterone

Synthase Between Aldosterone-Producing Microadenomas and Macroadenomas. Hypertension. 64(2):438-444.

2014 （原著）

825. Taniuchi S, Fujishima F, Miki Y, Abe K, Nakamura Y, Sato S, Kasajima A, Fue M, Ishida K, Watanabe M,

Sakakibara T, Maeda S, Suzuki T, Sasano H. Tissue concentrations of estrogens and aromatase

immunolocalization in interstitial pneumonia of human lung. Mol Cell Endocrinol. 392(1-2):136-143. 2014 （原

著）

826. Takagi K, Moriguchi T, Miki Y, Nakamura Y, Watanabe M, Ishida T, Yamamoto M, Sasano H, Suzuki T.

GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor. Cancer Sci. 105(5):600-607.

2014 （原著）

827. Inoue T, Miki Y, Kakuo S, Hachiya A, Kitahara T, Aiba S, Zouboulis CC, Sasano H. Expression of

steroidogenic enzymes in human sebaceous glands. J Endocrinol. 222(3):301-312. 2014 （原著）

828. McNamara KM, Moore NL, Hickey TE, Sasano H, Tilley WD. Complexities of androgen receptor signalling

in breast cancer. Endocr Relat Cancer. 21(4):T161-81. 2014 （総説）

829. Ito S, Tase T, Satoh K, Ueki M, Sato I, Sasano H. Gastric-type endocervical glandular neoplasms

associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome. Pathol Int.

64(6):283-288. 2014 （症例）

830. Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H,

Zouboulis CC, Aiba S, Sasano H. Steroidogenic enzymes, their related transcription factors and nuclear

receptors in human sebaceous glands under normal and pathological conditions. J Steroid Biochem Mol Biol.

144 Pt B:268-279. 2014 （原著）

831. Nagasaki S, Fukui M, Asano S, Ono K, Miki Y, Araki S, Isobe M, Nakashima N, Takahashi K, Sasano H,

Sato J. Induction of adrenomedullin 2/intermedin expression by thyroid stimulating hormone in thyroid. Mol Cell

Endocrinol. 395(1-2):32-40. 2014 （原著）

832. Bachurska S, Staykov D, Belovezhdov V, Sasano H, Gulinac M, Stefanov C, Neumann HP. Bilateral

pheochromocytoma/intra-adrenal paraganglioma in von Hippel-Lindau patient causing acute myocardial

infarction. Pol J Pathol. 65(1):78-82. 2014 （症例）

833. Felizola SJ, Maekawa T, Nakamura Y, Satoh F, Ono Y, Kikuchi K, Aritomi S, Ikeda K, Yoshimura M, Tojo K,

Sasano H. Voltage-gated calcium channels in the human adrenal and primary aldosteronism. J Steroid

Biochem Mol Biol. 144 Pt B:410-416. 2014 （原著）

834. Fujii R, Hanamura T, Suzuki T, Gohno T, Shibahara Y, Niwa T, Yamaguchi Y, Ohnuki K, Kakugawa Y,

Hirakawa H, Ishida T, Sasano H, Ohuchi N, Hayashi SI. Increased androgen receptor activity and cell

proliferation in aromatase inhibitor-resistant breast carcinoma. J Steroid Biochem Mol Biol. 144 Pt B:513-522.

2014 （原著）

835. Saito R, Yanai M, Miki Y, Fukasawa Y, Tominaga J, Ebina M, Sasano H. Immunohistochemical Evidence

for the Association between Attenuated mTOR Signaling and Diffuse Alveolar Damage, A Fatal Lung

Complication. Tohoku J Exp Med. 234(1):67-75. 2014 （症例）

836. Sasano H, Nakamura Y, Satoh F. Endocrine Pathology: SY08-1 IDENTIFICATION OF ALDOSTERONE

PRODUCTION SITES IN PRIMARY ALDOSTERONISM. Pathology. 46 Suppl 2:S14. 2014 （総説）

837. Yoda T, McNamara KM, Miki Y, Takagi M, Rai Y, Ohi Y, Sagara Y, Tamaki K, Hirakawa H, Ishida T, Suzuki T,

Ohuchi N, Sasano H. Intratumoral androgen metabolism and actions in invasive lobular carcinoma of the breast.

Cancer Sci. 105(11):1503-1509. 2015 （原著）

838. Sasano H, Satoh F, Nakamura Y. Roles of the pathologist in evaluating surrogate markers for medical

therapy in adrenocortical carcinoma. Endocr Pathol. 25(4):366-370. 2014 （総説）

839. Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K.

Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human

endometrial carcinoma: CRHR1 as a potent prognostic factor. Int J Gynecol Cancer. 24(9):1549-1557. 2014 （原

著）

840. Nakamura Y, Felizola SJ, Satoh F, Konosu-Fukaya S, Sasano H. Dissecting the molecular pathways of

primary aldosteronism. Pathol Int. 64(10):482-489. 2014 （総説）

841. Tamaki K, Tamaki N, Terukina S, Kamada Y, Uehara K, Arakaki M, Miyashita M, Ishida T, McNamara KM,

Ohuchi N, Sasano H. The Correlation between Body Mass Index and Breast Cancer Risk or Estrogen Receptor

Status in Okinawan Women. Tohoku J Exp Med. 234(3):169-174. 2014 （原著）

842. Sato N, Nakamura Y, Takanami K, Ono Y, Omata K, Morimoto R, Satoh F, Ise K, Yamada S, Kasajima A,

Fujishima F, Watanabe M, Arai Y, Sasano H. Case study: adrenal oncocytoma associated with markedly

increased FDG uptake and immunohistochemically positive for GLUT1. Endocr Pathol. 25(4):410-415. 2014 （症

例）

843. Eguchi K, Hoshide S, Nagashima S, Maekawa T, Sasano H, Kario K. An Adverse Pregnancy-associated

Outcome due to Overlooked Primary Aldosteronism. Intern Med. 53(21):2499-2504. 2014 （症例）

844. Miyashita M, Sasano H, Tamaki K, Chan M, Hirakawa H, Suzuki A, Tada H, Watanabe G, Nemoto N,

Nakagawa S, Ishida T, Ohuchi N. Tumor-infiltrating CD8+ and FOXP3+ lymphocytes in triple-negative breast

cancer: its correlation with pathological complete response to neoadjuvant chemotherapy. Breast Cancer Res

Treat. 148(3):525-534. 2014 （原著）

845. Felizola SJ, Nakamura Y, Ozawa Y, Ono Y, Morimoto R, Midorikawa S, Suzuki S, Satoh F, Sasano H.

Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone

Biosynthesis. Tohoku J Exp Med. 234(4):249-254. 2014 （原著）

846. Konosu-Fukaya S, Nakamura Y, Satoh F, Felizola SJ, Maekawa T, Ono Y, Morimoto R, Ise K, Takeda KI,

Katsu K, Fujishima F, Kasajima A, Watanabe M, Arai Y, Gomez-Sanchez EP, Gomez-Sanchez CE, Doi M,

Okamura H, Sasano H. 3β -hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.

Mol Cell Endocrinol. 408:205-212. 2015 （原著）

847. Yasuda A, Seki T, Ito K, Takagi A, Watanabe D, Nakamura N, Hanai K, Terachi T, Maekawa T, Sasano H,

Fukagawa M. A rare case of Cushing's syndrome due to bilateral adrenocortical adenomas. Tokai J Exp Clin

Med. 39(4):158-165. 2014 （症例）

848. Yang Y, Suzuki K, Abe E, Li C, Uno M, Akiyama F, Yamauchi H, Kikuchi M, Ohde S, Deshpande G,

Shibahara Y, Nakamura Y, Sasano H. The significance of combined CK5/6 and p63 immunohistochemistry in

predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. Pathol Int.

65(2):81-88. 2015 （原著）

849. Nemoto N, Shibahara Y, Tada H, Uchida K, McNamara KM, Chan MS, Watanabe M, Tamaki K, Miyashita M,

Miki Y, Gonda K, Ishida T, Ohuchi N, Sasano H. Clinical significance of subtype classification in metastatic

lymph nodes of breast cancer patients undergoing neoadjuvant chemotherapy. Int J Biol Markers.

30(2):e174-183. 2015 （原著）

850. McNamara KM, Yoda T, Miki Y, Nakamura Y, Suzuki T, Nemoto N, Miyashita M, Nishimura R, Arima N,

Tamaki K, Ishida T, Ohuchi N, Sasano H. Androgen receptor and enzymes in lymph node metastasis and

cancer reoccurrence in triple-negative breast cancer. Int J Biol Markers. 30(2):e184-189. 2015 （原著）

851. Murakami K, Kasajima A, Kawagishi N, Ohuchi N, Sasano H. Microvessel density in hepatocellular

carcinoma: prognostic significance and review of the previous literature. Hepatol Res. 45(12):1185-1194. 2015

（原著）

852. Narumi S, Miki Y, Hata S, Ebina M, Saito M, Mori K, Kobayashi M, Suzuki T, Iwabuchi E, Sato I, Maemondo

M, Endo C, Inoue A, Kondo T, Yamada-Okabe H, Ichinose M, Sasano H. Anterior gradient 2 is correlated with

EGFR mutation in lung adenocarcinoma tissues. Int J Biol Markers. 30(2):e234-242. 2015 （原著）

853. Wang X, Docanto MM, Sasano H; Kathleen Cuningham Foundation Consortium for Research into Familial

Breast Cancer, Lo C, Simpson ER, Brown KA. Prostaglandin E2 Inhibits p53 in Human Breast Adipose Stromal

Cells: A Novel Mechanism for the Regulation of Aromatase in Obesity and Breast Cancer. Cancer Res.

75(4):645-655. 2015 （原著）

854. Kasajima A, Yazdani S, Sasano H. Pathology diagnosis of pancreatic neuroendocrine tumors. J

Hepatobiliary Pancreat Sci. 22(8):586-593. 2015 （総説）

855. Kasajima A, Fujishima F, Morikawa T, Kawasaki S, Konosu-Fukaya S, Shibahara Y, Nakamura T,

Yoshikawa T, Iijima K, Koike T, Watanabe M, Shibata C, Sasano H. G-cell hyperplasia of the stomach induces

ECL-cell proliferation in the pyloric glands in a paracrinal manner. Pathol Int. 65(5):259-263. 2015 （症例）

856. Monno S, Tachikawa T, Maekawa T, Sasano H. A case of Cushing's syndrome due to bilateral

cortisol-secreting adenomas with unilateral DHEAS oversecretion. Endocr J. 62(3):283-288. 2015 （症例）

857. Shibahara I, Saito R, Zhang R, Chonan M, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi

T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, Tominaga T. OX40

ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for

successful immunotherapy. Mol Cancer. 14:41. 2015 （原著）

858. Kakita-Kobayashi M, Usui T, Sasano H, Shimatsu A. 18F-FDG-PET-positive adrenal tumour. BMJ Case

Rep. 2015 Mar 6;2015. pii: bcr2015209379. （症例）

859. Ozawa Y, Nakamura Y, Fujishima F, Felizola SJ, Takeda K, Okamoto H, Ito K, Ishida H, Konno T, Kamei T,

Ohuchi N, Sasano H. Decreased Expression of ARID1A Contributes to Infiltrative Growth of Esophageal

Squamous Cell Carcinoma. Tohoku J Exp Med. 235(3):185-191. 2015 （原著）

860. Satoh F, Morimoto R, Ono Y, Iwakura Y, Omata K, Kudo M, Takase K, Seiji K, Sasamoto H, Honma S,

Okuyama M, Yamashita K, Gomez-Sanchez CE, Rainey WE, Arai Y, Sasano H, Nakamura Y, Ito S.

Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases

in patients with primary aldosteronism. Hypertension. 65(5):1096-1102. 2015 （原著）

861. Yazdani S, Kasajima A, Ogata H, Felizola SJ, Nakamura Y, Onodera Y, Motoi F, Unno M, Watanabe M,

Sasano H. Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor. Neuroendocrinology.

101(4):309-320. 2015 （原著）

862. Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H. Pre-B Lymphocyte Protein 3

(VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic

Human Tissues. Endocr Pathol. 26(2):119-128. 2015 （原著）

863. Yoda T, McNamara KM, Miki Y, Onodera Y, Takagi K, Nakamura Y, Ishida T, Suzuki T, Ohuchi N, Sasano H.

KLF15 in breast cancer: a novel tumor suppressor? Cell Oncol (Dordr). 38(3):227-235. 2015 （原著）

864. Takagi K, Miki Y, Nakamura Y, Hirakawa H, Kakugawa Y, Amano G, Watanabe M, Ishida T, Sasano H,

Suzuki T. Immunolocalization of thymidylate synthase as a favorable prognostic marker in estrogen

receptor-positive breast carcinoma. Histol Histopathol. 30(10):1223-1232. 2015 （原著）

865. Okamoto H, Fujishima F, Kamei T, Nakamura Y, Ozawa Y, Miyata G, Nakano T, Katsura K, Abe S, Taniyama

Y, Sakurai T, Teshima J, Hikage M, Sasano H, Ohuchi N. Murine double minute 2 predicts response of

advanced esophageal squamous cell carcinoma to definitive chemoradiotherapy. BMC Cancer. 15:208. 2015

（原著）

866. Murakami M, Suzuki T, Wu TW, Kuwasako K, Takahashi E, Watanabe H, Murakami AM, Miyoshi I,

Yanagisawa T, Sasano H, Ono K, Ohba T. Modified autonomic regulation in mice mutated in the β4 subunit of

the lh/lh calcium channel. Biochem Biophys Res Commun. 461(2):200-205. 2015 （原著）

867. Sakurai M, Masuda M, Miki Y, Hirakawa H, Suzuki T, Sasano H. Correlation of miRNA expression profiling

in surgical pathology materials, with Ki-67, HER2, ER and PR in breast cancer patients. Int J Biol Markers.

30(2):e190-199. 2015 （原著）

868. Nakamura Y, McNamara KM, Onodera S, Kitamoto Y, Kisu K, Shibahara Y, Kurosu A, Sasano H, Sato H,

Joh K. Hypoelectrolytic isoosmotic solution for infusion prevents saline-induced ultrastuructural artifacts of renal

biopsy specimens. Pathol Int. 65(7):374-378. 2015 （原著）

869. Toi M, Winer EP, Benson JR, Inamoto T, Forbes JF, von Minckwitz G, Robertson JF, Grobmyer SR, Jatoi I,

Sasano H, Kunkler I, Ho AY, Yamauchi C, Chow LW, Huang CS, Han W, Noguchi S, Pegram MD, Yamauchi H,

Lee ES, Larionov AA, Bevilacqua JL, Yoshimura M, Sugie T, Yamauchi A, Krop IE, Noh DY, Klimberg VS; 2014

Kyoto Breast Cancer Consensus Conference. Personalization of loco-regional care for primary breast cancer

patients (part 1).

Future Oncol. 11(9):1297-1300. 2015 （総説）

870. Toi M, Winer EP, Benson JR, Inamoto T, Forbes JF, von Minckwitz G, Robertson JF, Grobmyer SR, Jatoi I,

Sasano H, Kunkler I, Ho AY, Yamauchi C, Chow LW, Huang CS, Han W, Noguchi S, Pegram MD, Yamauchi H,

Lee ES, Larionov AA, Bevilacqua JL, Yoshimura M, Sugie T, Yamauchi A, Krop IE, Noh DY, Klimberg VS; 2014

Kyoto Breast Cancer Consensus Conference. Personalization of loco-regional care for primary breast cancer

patients (part 2).

Future Oncol. 11(9):1301-1305. 2015 （総説）

871. Sato S, Watanabe M, Taniuchi S, Kasajima A, Mitsuzuka K, Nakamura Y, Fujishima F, Arai Y, Sasano H.

Precise preoperative localization of prostate cancer employing 12-core needle biopsy with a tissue-marking

method for effective surgical strategy. Tohoku J Exp Med. 236(1):55-61. 2015 （原著）

872. Ozawa Y, Nakamura Y, Fujishima F, Felizola SJ, Takeda K, Okamoto H, Ito K, Ishida H, Konno T, Kamei T,

Miyata G, Ohuchi N, Sasano H. c-Met in esophageal squamous cell carcinoma: an independent prognostic

factor and potential therapeutic target. BMC Cancer. 15:451. 2015 （原著）

873. Nakamura Y, Yamazaki Y, Felizola SJ, Ise K, Morimoto R, Satoh F, Arai Y, Sasano H. Adrenocortical

Carcinoma: Review of the Pathologic Features, Production of Adrenal Steroids, and Molecular Pathogenesis.

Endocrinol Metab Clin North Am. 44(2):399-410. 2015 （総説）

874. Nakamura Y, Yamazaki Y, Konosu-Fukaya S, Ise K, Satoh F, Sasano H. Aldosterone biosynthesis in the

human adrenal cortex and associated disorders. J Steroid Biochem Mol Biol. 153:57-62. 2015 （総説）

875. McNamara KM, Sasano H. Beyond the C18 frontier: Androgen and glucocorticoid metabolism in breast

cancer tissues: The role of non-typical steroid hormones in breast cancer development and progression.

Steroids. 103:115-122. 2015 （総説）

876. Mei X, Xia Y, Sasano H, Gao H. Sinonasal yolk sac (Endodermal sinus) tumor in an adult female - A case

study and review of the literature. APMIS. 123(9):810-814. 2015 （症例）

877. Satoh F, Morimoto R, Ono Y, Iwakura Y, Omata K, Kudo M, Tkase K, Seiji K, Gomez-Sanchez C, Rainey W,

Nakamura Y, Sasano H, Ito S. 8D.02: PERIPHERAL PLASMA 18-OXOCORTISOL CAN DISCRIMINATE

UNILATERAL ADENOMA FROM BILATERAL DISEASES IN PRIMARY ALDOSTERONISM PATIENTS. J

Hypertens. 33 Suppl 1:e113. 2015 （原著）

878. Satoh F, Morimoto R, Ono Y, Iwakura Y, Omata K, Kudo M, Satani N, Ota H, Seiji K, Takase K, Nakamura Y,

Sasano H, Ito S. 8D.04: CLINICAL BENEFITS OF ADMINISTERING SUPER-SELECTIVE SEGMENTAL

ADRENAL VENOUS SAMPLING AND PERFORMING ADRENAL SPARING SURGERY IN THE PATIENTS

WITH PRIMARY ALDOSTERONISM. J Hypertens. 33 Suppl 1:e114. 2015 （原著）

879. Azmahani A, Nakamura Y, McNamara KM, Sasano H. The Role of Androgen under Normal and

Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy. Curr Mol Pharmacol.

9(4):311-319. 2016 （総説）.

880. Yoda T, Kikuchi K, Miki Y, Onodera Y, Hata S, Takagi K, Nakamura Y, Hirakawa H, Ishida T, Suzuki T,

Ohuchi N, Sasano H, McNamara KM. 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3,

stimulates Prostaglandin F receptor and induces Slug expression in breast cancer. Mol Cell Endocrinol.

413:236-247. 2015 （原著）

881. Satoh F, Morimoto R, Seiji K, Satani N, Ota H, Iwakura Y, Ono Y, Kudo M, Nezu M, Omata K, Tezuka Y,

Kawasaki Y, Ishidoya S, Arai Y, Takase K, Nakamura Y, McNamara K, Sasano H, Ito S. Is there a role for

segmental adrenal venous sampling and adrenal sparing surgery in patients with primary aldosteronism? Eur J

Endocrinol. 173(4):465-477. 2015 （総説）

882. Suzuki S, Tatsuno I, Oohara E, Nakayama A, Komai E, Shiga A, Kono T, Takiguchi T, Higuchi S, Sakuma I,

Nagano H, Hashimoto N, Mayama T, Koide H, Sasano H, Nakatani Y, Imamoto T, Ichikawa T, Yokote K, Tanaka

T. GERMLINE DELETION OF ARMC5 IN FAMILIAL PRIMARY MACRONODULAR ADRENAL HYPERPLASIA.

Endocr Pract. 21(10):1152-1160. 2015 （原著）

883. Adachi K, Miki Y, Saito R, Hata S, Yamauchi M, Mikami Y, Okada Y, Seyama K, Kondo T, Sasano H.

Intracrine steroid production and mammalian target of rapamycin pathways in pulmonary

lymphangioleiomyomatosis. Hum Pathol. 46(11):1685-1693. 2015 （原著）

884. Minemura H, Takagi K, Miki Y, Shibahara Y, Nakagawa S, Ebata A, Watanabe M, Ishida T, Sasano H,

Suzuki T. Abnormal expression of miR-1 in breast carcinoma as a potent prognostic factor. Cancer Sci.

106(11):1642-1650. 2015 （原著）

885. Miyashita M, Sasano H, Tamaki K, Hirakawa H, Takahashi Y, Nakagawa S, Watanabe G, Tada H, Suzuki A,

Ohuchi N, Ishida T. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual

tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a

retrospective multicenter study. Breast Cancer Res. 17:124. 2015 （原著）

886. Azmahani A, Nakamura Y, Ozawa Y, McNamara KM, Fujimura T, Haga T, Hashimoto A, Aiba S, Sasano H.

Androgen receptor, androgen-producing enzymes and their transcription factors in extramammary Paget

disease. Hum Pathol. 46(11):1662-1669. 2015 （原著）

887. Inomata A, Sasano H. Practical approaches for evaluating adrenal toxicity in nonclinical safety

assessment. J Toxicol Pathol. 28(3):125-132. 2015 （総説）

888. Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H,

Zouboulis CC, Aiba S, Sasano H. Reply to comments to "Letter to the Editor: comment on Azmahani et al.

steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands

under normal and pathological conditions". J Steroid Biochem Mol Biol. 155(Pt A):178-180. 2016 （原著）

889. Zhang Y, Dai J, McNamara KM, Bai B, Shi M, Chan MS, Liu M, Sasano H, Wang X, Li X, Liu L, Ma Y, Cao

S, Xing Y, Zhao B, Song Y, Wang L. Prognostic significance of proline, glutamic acid, leucine rich protein 1

(PELP1) in triple-negative breast cancer: a retrospective study on 129 cases. BMC Cancer. 15: 699. 2015 （原

著）

890. Morimoto R, Satani N, Iwakura Y, Ono Y, Kudo M, Nezu M, Omata K, Tezuka Y, Seiji K, Ota H, Kawasaki Y,

Ishidoya S, Nakamura Y, Arai Y, Takase K, Sasano H, Ito S, Satoh F. A case of bilateral aldosterone-producing

adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery. J Hum

Hypertens. 30(6):379-385. 2016 （原著）

891. Okubo Y, Sato Y, Nakasone Y, Shirotori K, Oguchi K, Matsushita T, Nishikawa T, Yamazaki Y, Sasano H,

Komtasu M, Yamauchi K, Aizawa T. Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary

aldosteronism: an insight into the underlying mechanism. Endocr J. 63(2):127-133. 2016 （症例）

892. Nakamura Y, Kitada M, Satoh F, Maekawa T, Morimoto R, Yamazaki Y, Ise K, Gomez-Sanchez CE, Ito S,

Arai Y, Dezawa M, Sasano H. Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma

revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17. Mol Cell Endocrinol.

422:57-63. 2016 （原著）

893. Kitamoto T, Suematsu S, Yamazaki Y, Nakamura Y, Sasano H, Matsuzawa Y, Saito J, Omura M, Nishikawa

T. Clinical and Steroidogenic characteristics of Aldosterone-producing Adenomas with ATPase or CACNA1D

gene mutations. J Clin Endocrinol Metab. 101(2):494-503. 2016 （原著）

894. Guestini F, McNamara KM, Ishida T, Sasano H. Triple Negative Breast Cancer Chemosensitivity and

Chemoresistance: Current Advances in Biomarkers Indentification. Expert Opin Ther Targets. 20(6):705-720.

2016 （総説）

895. Ishida H, Nakano T, Fujishima F, Kamei T, Taniyama Y, Sakurai T, Sato C, Fukutomi T, Kamiya K, Ozawa Y,

Sasano H, Ohuchi N. Surgical resection and chemoradiotherapy for metachronous pulmonary metastasis of

basaloid squamous cell carcinoma of the oesophagus. Int J Surg Case Rep. 17:151-154. 2015 （原著）

896. Rizner TL, Sasano H, Choi MH, Odermatt A, Adamski J. Recommendations for description and validation

for antibodies for research use. J Steroid Biochem Mol Biol. 156:40-42. 2016 （総説）

897. Lalli E, Sasano H. 5th International ACC Symposium: An Outlook to Current and Future Research on the

Biology of Adrenocortical Carcinoma: Diagnostic and Therapeutic Applications. Horm Cancer. 7(1):44-48. 2016

（総説）

898. Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A,

Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.

Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven

Positive-Feedback Loop. J Clin Endocrinol Metab. 101(3):841-846. 2016 （原著）

899. Nakagawa S, Miki Y, Miyashita M, Hata S, Takahashi Y, Rai Y, Sagara Y, Ohi Y, Hirakawa H, Tamaki K,

Ishida T, Watanabe M, Suzuki T, Ohuchi N, Sasano H. Tumor microenvironment in invasive lobular carcinoma:

possible therapeutic targets. Breast Cancer Res Treat. 155(1):65-75. 2016 （原著）

900. Ohashi K, Hayashi T, Sakamoto M, Iuchi H, Suzuki H, Ebisawa T, Tojo K, Sasano H, Utsunomiya K.

Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy:

a case study. BMC Endocr Disord. 16:3. 2016 （症例）

901. Takagi K, Miki Y, Tanaka S, Hashimoto C, Watanabe M, Sasano H, Ito K, Suzuki T. Nucleobindin 2

(NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and

migration. Endocr J. 63(3):287-299. 2016 （原著）

902. Pilon C, Rebellato A, Urbanet R, Guzzardo V, Cappellesso R, Sasano H, Fassina A, Fallo F. Methylation

Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors. Int J Endocrinol.

2015:375349. 2015 （原著）

903. Kasajima A, Cameselle-Teijeiro J, Loidi L, Takahashi Y, Nakashima N, Sato S, Fujishima F, Watanabe M,

Nakazawa T, Naganuma H, Kondo T, Kato R, Sasano H. A Calcitonin Non-producing Neuroendocrine Tumor of

the Thyroid Gland. Endocr Pathol. 27(4):325-331. 2016 （症例）

904. Iwakura Y, Ito S, Morimoto R, Kudo M, Ono Y, Nezu M, Takase K, Seiji K, Ishidoya S, Arai Y, Funamizu Y,

Miki T, Nakamura Y, Sasano H, Satoh F. Renal Resistive Index Predicts Postoperative Blood Pressure Outcome

in Primary Aldosteronism. Hypertension. 67(3):654-660. 2016 （原著）

905. Ohara N, Kaneko M, Sato K, Usuda H, Tanaka J, Maekawa T, Sasano H, Katakami H, Kaneko K, Kamoi K.

Acute Exacerbation of Idiopathic Pulmonary Fibrosis Following Treatment for Cushing's Syndrome. Intern Med.

55(4):389-394. 2016 （症例）

906. Saito R, Fujishima F, Nakamura Y, Hoshikawa Y, Tominaga J, Taniuchi S, Kasajima A, Watanabe M, Okada

Y, Sasano H. A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by

immunohistochemical and genetic analyses. Pathol Int. 66(4):224-229. 2016 （症例）

907. Takagi M, Miki Y, Miyashita M, Hata S, Yoda T, Hirakawa H, Sagara Y, Rai Y, Ohi Y, Tamaki K, Ishida T,

Suzuki T, Ouchi N, Sasano H. Intratumoral estrogen production and actions in luminal A type invasive lobular

and ductal carcinomas. Breast Cancer Res Treat. 156(1):45-55. 2016 （原著）

908. McNamara KM, Sasano H. Androgen and breast cancer: an update. Curr Opin Endocrinol Diabetes Obes.

23(3):249-256. 2016 （総説）

909. Asakawa M, Yoshimoto T, Ota M, Numasawa M, Sasahara Y, Takeuchi T, Nakano Y, Oohara N, Murakami

M, Bouchi R, Minami I, Tsuchiya K, Hashimoto K, Izumiyama H, Kawamura N, Kihara K, Negi M, Akashi T, Eishi

Y, Sasano H, Ogawa Y. A Case of Cushing's Syndrome with Multiple Adrenocortical Adenomas Composed of

Compact Cells and Clear Cells. Endocr Pathol. 27(2):136-141. 2016 （症例）

910. Yamazaki Y, Nakamura Y, Shibahara Y, Konosu-Fukaya S, Sato N, Kubota F, Oki Y, Baba S, Midorikawa S,

Morimoto R, Satoh F, Sasano H. Comparison of the methods for measuring the Ki-67 labeling index in

adrenocortical carcinoma: manual versus digital image analysis. Hum Pathol. 53:41-50. 2016 （原著）

911. Ueno T, Saji S, Sugimoto M, Masuda N, Kuroi K, Sato N, Takei H, Yamamoto Y, Ohno S, Yamashita H,

Hisamatsu K, Aogi K, Iwata H, Imoto S, Sasano H, Toi M. Clinical significance of the expression of

autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy.

BMC Cancer. 16:230. 2016 （原著）

912. McNamara KM, Guestini F, Sakurai M, Kikuchi K, Sasano H. How far have we come in terms of estrogens

in breast cancer? [Review]. Endocr J. 63(5):413-424. 2016 （総説）

913. Ishida K, Sasano H, Moriya T, Takahashi Y, Sugimoto R, Mue Y, Murakami K, Fujishima F, Nakamura Y,

Morikawa T, Motoi F, Suzuki T, Unno M, Sugai T. Immunohistochemical analysis of steroidogenic enzymes in

ovarian-type stroma of pancreatic mucinous cystic neoplasms: Comparative study of subepithelial stromal cells

in intraductal papillary mucinous neoplasms of the pancreas. Pathol Int. 66(5):281-287. 2016 （原著）

914. Kubota-Nakayama F, Nakamura Y, Konosu-Fukaya S, Azmahani A, Ise K, Yamazaki Y, Kitawaki Y, Felizola

SJ, Ono Y, Omata K, Morimoto R, Iwama N, Satoh F, Sasano H. Expression of steroidogenic enzymes and their

transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and

quantitative real-time polymerase chain reaction studies. Hum Pathol. 54:165-173. 2016 （原著）

915. Matsubara F, Katabami T, Asai S, Ariizumi Y, Maeda I, Takagi M, Keely MM, Ono K, Maekawa T, Nakamura

Y, Tanaka Y, Sasano H. Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic

schwannoma/peripheral nerve sheath tumour. J Int Med Res. 44(3):662-672. 2016 （原著）

916. Miki Y, Hata S, Nagasaki S, Suzuki T, Ito K, Kumamoto H, Sasano H. Steroid and xenobiotic

receptor-mediated effects of bisphenol A on human osteoblasts. Life Sci. 155:29-35. 2016 （原著）

917. Katsushima H, Fukuhara N, Ichikawa S, Ota Y, Takeuchi K, Ishizawa K, Sasano H, Harigae H,

Ichinohasama R. Non-biased and complete case registration of lymphoid leukemia and lymphoma for five

years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture. Leuk Lymphoma.

58(1):80-88. 2017 （原著）

918. Zhang L, Yao M, Hisaoka M, Sasano H, Gao H. Primary Ewing sarcoma/primitive neuroectodermal tumor

in the adrenal gland. APMIS. 124(7):624-629. 2016 （症例）

919. Iwabuchi E, Miki Y, Ono K, Onodera Y, Suzuki T, Hirakawa H, Ishida T, Ohuchi N, Sasano H. In situ

detection of estrogen receptor dimers in breast carcinoma cells in archival materials using proximity ligation

assay (PLA). J Steroid Biochem Mol Biol. 165(Pt B):159-169. 2017 （原著）

920. Ito K, Miki Y, Suzuki T, McNamara KM, Sasano H. In situ androgen and estrogen biosynthesis in

endometrial cancer: focus on androgen actions and intratumoral production. Endocr Relat Cancer.

23(7):R323-335. 2016 （総説）

921. Onodera Y, Takagi K, Miki Y, Takayama KI, Shibahara Y, Watanabe M, Ishida T, Inoue S, Sasano H, Suzuki

T. TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor

associated with cell proliferation. Cancer Med. 5(8):1973-1982. 2016 （原著）

922. Azmahani A, Nakamura Y, Ishida H, McNamara KM, Fujimura T, Haga T, Hashimoto A, Aiba S, Sasano H.

Estrogen receptor β in Merkel cell carcinoma: its possible roles in pathogenesis. Hum Pathol. 56:128-133. 2016

（原著）

923. Katagiri M, Karasawa H, Takagi K, Nakayama S, Yabuuchi S, Fujishima F, Naitoh T, Watanabe M, Suzuki T,

Unno M, Sasano H. Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis,

proliferation and migration. Histol Histopathol. 32(4):351-360. 2017 （原著）

924. Tamura A, Nishimoto K, Seki T, Matsuzawa Y, Saito J, Omura M, Gomez-Sanchez CE, Makita K, Matsui S,

Moriya N, Inoue A, Nagata M, Sasano H, Nakamura Y, Yamazaki Y, Kabe Y, Mukai K, Kosaka T, Oya M,

Suematsu S, Nishikawa T. Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel

form of juvenile primary aldosteronism. Mol Cell Endocrinol. 441:134-139. 2017 （原著）

925. Mineo R, Tamba S, Yamada Y, Okita T, Kawachi Y, Mori R, Kyo M, Saisho K, Kuroda Y, Yamamoto K,

Furuya A, Mukai T, Maekawa T, Nakamura Y, Sasano H, Matsuzawa Y. A Novel Mutation in the type Iα

Regulatory Subunit of Protein Kinase A (PRKAR1A) in a Cushing's Syndrome Patient with Primary Pigmented

Nodular Adrenocortical Disease. Intern Med. 55(17):2433-2438. 2016 （症例）

926. Murakami K, Nakamura Y, Felizola SJ, Morimoto R, Satoh F, Takanami K, Katakami H, Hirota S, Takeda Y,

Meguro-Horike M, Horike S, Unno M, Sasano H. Pancreatic solitary fibrous tumor causing ectopic

adrenocorticotropic hormone syndrome. Mol Cell Endocrinol. 436:268-273. 2016 （症例）

927. Rege J, Karashima S, Lerario AM, Smith JM, Auchus RJ, Kasa-Vubu JZ, Sasano H, Nakamura Y, White

PC, Rainey WE. Age-dependent increases in adrenal cytochrome b5 and serum 5-androstenediol-3-sulfate. J

Clin Endocrinol Metab. 101(12):4585-4593. 2016 （原著）

928. Minemura H, Takagi K, Sato A, Takahashi H, Miki Y, Shibahara Y, Watanabe M, Ishida T, Sasano H, Suzuki

T. CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and

chemoresistance. Cancer Sci. 107(12):1898-1908. 2016 （原著）

929. Kim SH, Moon JY, Sasano H, Choi MH, Park MJ. Body fat mass is associated with ratio of steroid

metabolites reflecting 17,20-lyase activity in prepubertal girls. J Clin Endocrinol Metab. 101(12):4653-4660.

2016 （原著）

930. Ohara N, Uemura Y, Mezaki N, Kimura K, Kaneko M, Kuwano H, Ebe K, Fujita T, Komeyama T, Usuda H,

Yamazaki Y, Maekawa T, Sasano H, Kaneko K, Kamoi K. Histopathological analysis of spontaneous large

necrosis of adrenal pheochromocytoma manifested as acute attacks of alternating hypertension and

hypotension: a case report. J Med Case Rep. 10(1):279. 2016 （原著）

931. Hirai H, Midorikawa S, Suzuki S, Sasano H, Watanabe T, Satoh H. Somatostatin-secreting

https://www.ncbi.nlm.nih.gov/pubmed/27514282












Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus. Intern Med. 55(20):2985-2991. 2016 （症

例）

932. Kasajima A, Sasano H. A case of multiple gastrointestinal endocrine and non-endocrine neoplasms.

Pathology. 48 Suppl 1:S131-S132. 2016 （症例）

933. Miyashita M, Gonda K, Tada H, Watanabe M, Kitamura N, Kamei T, Sasano H, Ishida T, Ohuchi N.

Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging.

Cancer Med. 5(10):2813-2824. 2016 （原著）

934. Gomez-Sanchez CE, Qi X, Gomez-Sanchez EP, Sasano H, Bohlen MO, Wisgerhof M. Disordered zonal

and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3. Mol Cell Endocrinol. 439:74-80.

2017 （原著）

935. McNamara KM, Oguro S, Omata F, Kikuchi K, Guestini F, Suzuki K, Yang Y, Abe E, Hirakawa H, Brown KA,

Takanori I, Ohuchi N, Sasano H. The presence and impact of estrogen metabolism on the biology of

triple-negative breast cancer. Breast Cancer Res Treat. 161(2):213-227. 2017 （総説）

936. Nakamura Y, Yamazaki Y, Tezuka Y, Satoh F, Sasano H. Expression of CYP11B2 in

Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance. Tohoku J

Exp Med. 240(3):183-190. 2016 （原著）

937. Hatano M, Takenaka Y, Inoue I, Homma K, Hasegawa T, Sasano H, Awata T, Katayama S. Feminizing

Adrenocortical Carcinoma with Distinct Histopathological Findings. Intern Med. 55(22):3301-3307. 2016 （症例）

938. Shibahara Y, Sugawara Y, Miki Y, Hata S, Takahashi H, Nakamura Y, Suzuki T, Ohuchi N, Tsuji I, Sasano H.

Analysis of multiple primary cancer autopsy cases associated with breast cancer: 2002-2010. Pathol Int.

66(12):695-700. 2016 （原著）

939. Saito R, Miki Y, Hata S, Ishida T, Suzuki T, Ohuchi N, Sasano H. Aryl hydrocarbon receptor induced

intratumoral aromatase in breast cancer. Breast Cancer Res Treat. 161(3):399-407. 2017 （原著）

940. Yamazaki Y, Nakamura Y, Omata K, Ise K, Tezuka Y, Ono Y, Morimoto R, Nozawa Y, Gomez-Sanchez CE,

Tomlins SA, Rainey WE, Ito S, Satoh F, Sasano H. Histopathological classification of cross-sectional image

negative hyperaldosteronism. J Clin Endocrinol Metab. 102(4):1182-1192. 2017 （原著）

941. Ohara N, Kaneko M, Ikeda M, Ishizaki F, Suzuki K, Maruyama R, Komeyama T, Sato K, Togashi K, Usuda

H, Yamazaki Y, Sasano H, Kaneko K, Kamoi K. Lung adenocarcinoma and adrenocortical carcinoma in a

patient with multiple endocrine neoplasia type 1. Respir Med Case Rep. 20:77-81. 2016 （症例）

942. Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y,

Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y,

Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H. Activation of the Hypoxia

Inducible Factor 1 Alpha Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones.

Gastroenterology. 152(6):1521-1535. 2017 （原著）

943. Sun PL, Sasano H, Gao H. Bcl-2 family in non-small cell lung cancer: its prognostic and therapeutic

implications. Pathol Int. 67(3):121-130. 2017 （総説）


944. Ishida H, Kasajima A, Kamei T, Miura T, Oka N, Yazdani S, Ozawa Y, Fujishima F, Sakurada A, Nakamura

Y, Tanaka Y, Kurosumi M, Ishikawa Y, Okada Y, Ohuchi N, Sasano H. SOX2 and Rb1 in esophageal small-cell

carcinoma: their possible involvement in pathogenesis. Mod Pathol. 30(5):660-671. 2017 （原著）

945. Tamaki K, Fukuyama AK, Terukina S, Kamada Y, Uehara K, Arakaki M, Yamashiro K, Miyashita M, Ishida T,

McNamara KM, Ohuchi N, Tamaki N, Sasano H. Randomized trial of aromatherapy versus conventional care

for breast cancer patients during perioperative periods. Breast Cancer Res Treat. 162(3):523-531. 2017 （原著）

946. Kawaguchi Y, Mizuno H, Horikawa M, Kano M, Yamada K, Yamakawa F, Maekawa T, Yamazaki Y,

McNamara KM, Sasano H, Hayashi M. Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma.

Tohoku J Exp Med. 241(2):125-129. 2017 （症例）

947. Nakamura Y, Ise K, Yamazaki Y, Fujishima F, McNamara KM, Sasano H.

Serotonin receptor 4 (5-hydroxytryptamine receptor Type 4) regulates expression of estrogen receptor beta and

cell migration in hormone-naive prostate cancer.

Indian J Pathol Microbiol. 60(1):33-37. 2017 （原著）

948. Kumata H, Miyagi S, Murakami K, Fujio A, Hara Y, Nakanishi C, Kawagishi N, Sasano H, Kamei T, Ouchi N.

Extrahepatic bile duct hepatocellular carcinoma due to recurrence of hematogenous metastasis 50 months after

hepatectomy. Surg Case Rep. 3(1):30. 2017 （症例）

949. Ito A, Yamazaki Y, Sasano H, Matsubara D, Fukushima N, Tamba M, Tabata K, Ashizawa K, Takei A,

Koizumi M, Sakuma Y, Sata N, Oshiro H. A case of primary aldosteronism caused by unilateral multiple

adrenocortical micronodules presenting as muscle cramps at rest: The importance of functional histopathology

for identifying a culprit lesion. Pathol Int. 67(4):214-221. 2017 （症例）

950. Hatta W, Koike T, Iijima K, Asanuma K, Asano N, Musha H, Inomata Y, Sano T, Endo H, Ikehata A, Horii T,

Ohyauchi M, Yokosawa S, Kasajima A, Fujishima F, Sasano H, Nakaya N, Nakamura T, Shimosegawa T. The

Risk Factors for Metastasis in Non-Ampullary Duodenal Neuroendocrine Tumors Measuring 20 mm or Less in

Diameter. Digestion. 95(3):201-209. 2017 （原著）

951. Santen RJ, Radisky DC, Degnim A, Frost MH, Vachon CM, Ghosh K, Guestini F, McNamara KM, Sasano

H. Aromatase expression in atypical ductal hyperplasia in women. Breast Cancer Res Treat. 163(3):623-629.

2017 （原著）

952. Omata K, Yamazaki Y, Nakamura Y, Anand SK, Barletta JA, Sasano H, Rainey WE, Tomlins SA, Vaidya A.

Genetic and Histopathologic Intertumor Heterogeneity in Primary Aldosteronism. J Clin Endocrinol Metab.

102(6):1792-1796. 2017 （原著）

953. Chishiki M, Takagi K, Sato A, Miki Y, Yamamoto Y, Ebata A, Shibahara Y, Watanabe M, Ishida T, Sasano H,

Suzuki T. Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.

Cancer Sci. 108(7):1510-1519. 2017 （原著）

954. Iwabuchi E, Miki Y, Ono K, Onodera Y, Sasano H. In Situ Evaluation of Estrogen Receptor Dimers in Breast

Carcinoma Cells: Visualization of Protein-Protein Interactions. Acta Histochem Cytochem. 50(2):85-93. 2017

（原著）

955. Nakayama S, Karasawa H, Suzuki T, Yabuuchi S, Takagi K, Aizawa T, Onodera Y, Nakamura Y, Watanabe

M, Fujishima F, Yoshida H, Morikawa T, Sase T, Naitoh T, Unno M, Sasano H. p62/sequestosome 1 in human

colorectal carcinoma as a potent prognostic predictor associated with cell proliferation. Cancer Med.

6(6):1264-1274. 2017 （原著）

956. Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno

S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M. Adjuvant Capecitabine for

Breast Cancer after Preoperative Chemotherapy. N Engl J Med. 376(22):2147-2159. 2017 （原著）

957. Miyashita M, Tada H, Suzuki A, Watanabe G, Hirakawa H, Amari M, Kakugawa Y, Kawai M, Furuta A, Sato

K, Yoshida R, Ebata A, Sasano H, Jingu K, Ohuchi N, Ishida T. Minimal impact of postmastectomy radiation

therapy on locoregional recurrence for breast cancer patients with 1 to 3 positive lymph nodes in the modern

treatment era. Surg Oncol. 26(2):163-170. 2017 （原著）

958. Satoh F, Sasano H, Yamazaki Y, Ito S. Aldosterone-Producing Adenomas: Genotypes and Phenotypes.

Hypertension. 70(1):38-41. 2017 （総説）

959. Palmieri C, Stein RC, Liu X, Hudson E, Nicholas H, Sasano H, Guestini F, Holcombe C, Barrett S, Kenny L,

Reed S, Lim A, Hayward L, Howell S, Coombes RC; IRIS trial participants. IRIS study: a phase II study of the

steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients.

Breast Cancer Res Treat. 165(2):343-353. 2017 （総説）

960. Sakurai M, Miki Y, Takagi K, Suzuki T, Ishida T, Ohuchi N, Sasano H. Interaction with adipocyte stromal

cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment. Breast

Cancer Res. 19(1):70. 2017 （総説）

961. Morimoto R, Ono Y, Tezuka Y, Kudo M, Yamamoto S, Arai T, Gomez-Sanchez CE, Sasano H, Ito S, Satoh

F. Rapid Screening of Primary Aldosteronism by a Novel Chemiluminescent Immunoassay. Hypertension.

70(2):334-341. 2017 （総説）

962. Takahashi K, Hatta W, Koike T, Kanno T, Ara N, Asanuma K, Asano N, Imatani A, Fujishima F, Sasano H,

Shimosegawa T. The slow progressive nature of duodenal neuroendocrine tumor: a case report of long-term

observation over 14 years. Clin J Gastroenterol. 10(5):469-473. 2017 （症例）

963. McNamara KM, Kannai A, Sasano H. Possible roles for glucocorticoid signalling in breast cancer. Mol Cell

Endocrinol. 2017 Jul 4. pii: S0303-7207(17)30358-1. doi: 10.1016/j.mce.2017.07.004 （総説） [Epub ahead of

print].

964. Takahashi N, Tanabe A, Yamazaki Y, Sasano H, Kajio H. Slowly-Growing Adrenal Mass: a 20-Year

Incubation. Am J Med. 130(11):e479-e483. 2017 No abstract available. （症例）

965. Nonaka K, Matsuda Y, Okaniwa A, Kasajima A, Sasano H, Arai T. Pancreatic gangliocytic paraganglioma

harboring lymph node metastasis: a case report and literature review. Diagn Pathol. 2;12(1):57-65. 2017 （症例）

966. Katsushima H, Fukuhara N, Konosu-Fukaya S, Himuro M, Kitawaki Y, Ichikawa S, Ishizawa K, Sasano H,

Harigae H, Ichinohasama R. Does double-hit follicular lymphoma with translocations of MYC and BCL2 change

the definition of transformation? Leuk Lymphoma. 59(3):758-762. 2018（原著）

967. Palmieri C, Szydlo R, Miller M, Barker L, Patel NH, Sasano H, Barwick T, Tam H, Hadjiminas D, Lee J,

Shaaban A, Nicholas H, Coombes RC, Kenny LM. IPET study: an FLT-PET window study to assess the activity

of the steroid sulfatase inhibitor irosustat in early breast cancer. Breast Cancer Res Treat. 166(2):527-539. 2017

（原著）

968. Kikuchi K, McNamara KM, Miki Y, Moon JY, Choi MH, Omata F, Sakurai M, Onodera Y, Rai Y, Ohi Y, Sagara

Y, Miyashita M, Ishida T, Ohuchi N, Sasano H. Effects of cytokines derived from cancer-associated fibroblasts

on androgen synthetic enzymes in estrogen receptor-negative breast carcinoma. Breast Cancer Res Treat.

166(3):709-723. 2017 （原著）

969. Harada R, Ishiki A, Kai H, Sato N, Furukawa K, Furumoto S, Tago T, Tomita N, Watanuki S, Hiraoka K,

Ishikawa Y, Funaki Y, Nakamura T, Yoshikawa T, Iwata R, Tashiro M, Sasano H, Kitamoto T, Yanai K, Arai H,

Kudo Y, Okamura N. Correlations of 18F-THK5351 PET with post-mortem burden of tau and astrogliosis in

Alzheimer's disease. J Nucl Med. 2017 Sep 1. pii: jnumed.117.197426. doi: 10.2967/jnumed.117.197426.（原

著） [Epub ahead of print]

970. Tokumoto M, Onoda N, Tauchi Y, Kashiwagi S, Noda S, Toi N, Kurajoh M, Ohsawa M, Yamazaki Y, Sasano

H, Hirakawa K, Ohira M. A case of Adrenocoricotrophic hormone -independent bilateral adrenocortical

macronodular hyperplasia concomitant with primary aldosteronism. BMC Surg. 17(1):97. 2017 （症例）

971. Takagi K, Miki Y, Ishida T, Sasano H, Suzuki T. The interplay of endocrine therapy, steroid pathways and

therapeutic resistance: Importance of androgen in breast carcinoma. Mol Cell Endocrinol. 2017 Sep 13. pii:

S0303-7207(17)30494-X. doi: 10.1016/j.mce.2017.09.011（原著）. [Epub ahead of print]

972. Hata S, Ise K, Azmahani A, Konosu-Fukaya S, McNamara KM, Fujishima F, Shimada K, Mitsuzuka K, Arai

Y, Sasano H, Nakamura Y. Expression of AR, 5αR1 and 5αR2 in bladder urothelial carcinoma and relationship

to clinicopathological factors. Life Sci. 190:15-20. 2017 （原著）

973. Chan MSM, Saito R, Takase K, Nakamura Y, Sasano H. The re-emerging importance of

radiologic-pathologic correlation in reaching the pathology diagnosis. Pathol Int. 67(11):537-538.2017 （解説）

974. Miki Y, Hata S, Ono K, Suzuki T, Ito K, Kumamoto H, Sasano H. Roles of Aryl Hydrocarbon Receptor in

Aromatase-Dependent Cell Proliferation in Human Osteoblasts. Int J Mol Sci. 18(10). 2017 （原著）

975. Inoue K, Yamazaki Y, Tsurutani Y, Suematsu S, Sugisawa C, Saito J, Omura M, Sasano H, Nishikawa T.

Evaluation of Cortisol Production in Aldosterone-Producing Adenoma. Horm Metab Res. 49(11):847-853. 2017

（原著）

976. Ito Y, Toyoshima H, Suzuki T, Iwamoto K, Sasano H, Itani H, Kondo S, Tanigawa M. Lung abscess caused

by Streptococcus pneumoniae serotype 6B. Respir Med Case Rep. 23:71-73. 2017 （症例）

977. Kasajima A, Papotti M, Ito W, Brizzi MP, La Salvia A, Rapa I, Tachibana T, Yazdani S, Sasano H, Volante M.

High interlaboratory and interobserver agreement of somatostatin receptor immunohistochemical determination

and correlation with response to somatostatin analogs. Hum Pathol. 144-152. 2018 （原著）

978. Babaya N, Makutani Y, Noso S, Hiromine Y, Ito H, Taketomo Y, Ueda K, Ushijima H, Komoike Y, Yamazaki

Y, Sasano H, Kawabata Y, Ikegami H. Case report: schwannoma arising from the unilateral adrenal area with

bilateral hyperaldosteronism. BMC Endocr Disord. 17(1):74. 2017 （症例）

979. Omata K, Anand SK, Hovelson DH, Liu CJ, Yamazaki Y, Nakamura Y, Ito S, Satoh F, Sasano H, Rainey

WE, Tomlins SA. Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate

With Age in Normal Adrenals. J Endocr Soc. 1(7):787-799. 2017 （原著）

980. Moon JY, McNamara KM, Lee JJ, Chung BC, Sasano H, Choi MH. Improved detectability of sex steroids

from frozen sections of breast cancer tissue using GC-triple quadrupole-MS. J Steroid Biochem Mol Biol.

178:185-192. 2018 （原著）

981. Kasajima A, Ishikawa Y, Iwata A, Steiger K, Oka N, Ishida H, Sakurada A, Suzuki H, Kameya T,

Konukiewitz B, Klöppel G, Okada Y, Sasano H, Weichert W. Inflammation and PD-L1 expression in pulmonary

neuroendocrine tumors. Endocr Relat Cancer. 25(3):339-350. 2018 （原著）

982. Yazdani S, Kasajima A, Onodera Y, McNamara KM, Ise K, Nakamura Y, Tachibana T, Motoi F, Unno M,

Sasano H. Progesterone arrested cell cycle progression through progesterone receptor isoform A in pancreatic

neuroendocrine neoplasm. J Steroid Biochem Mol Biol. 178:243-253. 2018 （原著）

983. Fujishima F, Taniyama Y, Nakamura Y, Okamoto H, Ozawa Y, Ito K, Ishida H, Konno-Kumagai T, Kasajima

A, Taniuchi S, Watanabe M, Kamei T, Sasano H. Residual carcinoma cells after chemoradiotherapy for

esophageal squamous cell carcinoma patients: striving toward appropriate judgment of biopsy. Dis Esophagus.

2018 Jan 13. doi: 10.1093/dote/dox141 （原著）. [Epub ahead of print]

984. Omata F, McNamara KM, Suzuki K, Abe E, Hirakawa H, Ishida T, Ohuchi N, Sasano H. Effect of the normal

mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients.

Breast Cancer. 2018 Feb 2. doi: 10.1007/s12282-018-0842-z （原著）. [Epub ahead of print]

985. Saito R, Miki Y, Ishida N, Inoue C, Kobayashi M, Hata S, Yamada-Okabe H, Okada Y, Sasano H. The

Significance of MMP-1 in EGFR-TKI-Resistant Lung Adenocarcinoma: Potential for Therapeutic Targeting. Int J

Mol Sci. 19(2). pii: E609. 2018（原著）

986. Palmieri C, Stein RC, Liu X, Hudson E, Nicholas H, Sasano H, Guestini F, Holcombe C, Barrett S, Kenny L,

Reed S, Lim A, Hayward L, Howell S, Charles Coombes R; IRIStrial participants. Correction to: IRIS study: a

phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive

breast cancer patients. Breast Cancer Res Treat. 167(1):407. 2018（原著）

987. Murakami K, Hata S, Miki Y, Sasano H. Aromatase in normal and diseased liver. Horm Mol Biol Clin

Investig. 2018 Feb 28. pii: /j/hmbci.ahead-of-print/hmbci-2017-0081/hmbci-2017-0081.xml. doi:

10.1515/hmbci-2017-0081 （総説）. [Epub ahead of print]

988. Ueno T, Saji S, Masuda N, Kuroi K, Sato N, Takei H, Yamamoto Y, Ohno S, Yamashita H, Hisamatsu K,

Aogi K, Iwata H, Yamanaka T, Sasano H, Toi M. Impact of clinical response to neoadjuvant endocrine therapy

on patient outcomes: a follow-up study of JFMC34-0601 multicentre prospective neoadjuvant endocrine trial.

ESMO Open. 3(2):e000314. 2018 （原著）

989. Takagi K, Miki Y, Onodera Y, Ishida T, Watanabe M, Sasano H, Suzuki T. ARHGAP15 in Human Breast

Carcinoma: A Potent Tumor Suppressor Regulated by Androgens. Int J Mol Sci. 19(3). pii: E804. 2018 （原著）

990. Mete O, Asa SL, Giordano TJ, Papotti M, Sasano H, Volante M. Immunohistochemical Biomarkers of

Adrenal Cortical Neoplasms. Endocr Pathol. 2018 Mar 14. doi: 10.1007/s12022-018-9525-8 （総説）. [Epub

ahead of print]

991. Tokodai K, Miyagi S, Nakanishi C, Hara Y, Nakanishi W, Miyazawa K, Shimizu K, Murakami K, Sasano H,

Goto M, Unno M, Kamei T. Association of post-transplant donor-specific HLA antibody with liver graft fibrosis

during long-term follow-up after pediatric liver transplantation. Pediatr Transplant. 2018 Mar 14. doi:

10.1111/petr.13169 （原著）. [Epub ahead of print]

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