© oxford university press 2009 these microbes got in through will’s cut finger. left unchecked...

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© Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues with toxins. We will discover how Will’s immune system can stop them. 2.2 Destroying invaders Slide 1

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Page 1: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

These microbes got in through Will’s cut finger.

Left unchecked they will reproduce rapidly and fill his blood and tissues with toxins.

We will discover how Will’s

immune system can stop them.

2.2 Destroying invaders

Slide 1

Page 2: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

It looks yellow on the image, but this is a white blood cell.

What is it doing?

‘Engulfing the bacteria?!!’

2.2 Destroying invaders

Slide 2

Page 3: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Once the bacteria are inside, enzymes destroy them.

The white cells eventually die and get broken down.

The broken down cells ooze out of wounds as pus.

2.2 Destroying invaders

Slide 3

Page 4: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Other types of white blood cells defend the body in different ways.

They make chemicals called antibodies which stick to microbes and make them easier to destroy.

They work against both bacteria and viruses.

2.2 Destroying invaders

Slide 4

Page 5: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

These Y-shaped particles are models of antibodies.

Each type of microbe needs a different antibody, so they aren’t made in advance. When a new microbe invades the body, it takes a couple of days to make them.

2.2 Destroying invaders

Slide 5

Page 6: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Once a white blood cell has made antibodies, it never forgets its target.

If that microbe returns, it makes antibodies straight away. So the microbes are destroyed before they can reproduce and cause disease…

...which makes you immune to that disease.

2.2 Destroying invaders

Slide 6

Page 7: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Paul is beginning to feel ill.

Bacteria have infected his throat.

He is under a lot of stress and it has weakened his immunity.

2.2 Destroying invaders

Slide 7

Page 8: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Explain what is happening in each part of the graph.

2.2 Destroying invaders

Slide 8

Page 9: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

2.2 Destroying invaders

What would help Paul get better quicker?

Slide 9

( Think about what most people do when they are ill. )

Page 10: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

2.2 Destroying invaders

Why doesn’t Paul notice the second infection?

Slide 10

Page 11: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

Asha has AIDs.

She gets a lot of infections and feels tired all the time.

This white cell used to help Asha make antibodies…

..but HIV particles have stoppedit working…

..so her immune system cannot protect her.

2.2 Destroying invaders

Slide 11

Page 12: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 12

Page 13: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 13

Page 14: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 14

Page 15: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 15

Page 16: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 16

Page 17: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 17

Page 18: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

The broken down cells ooze out of wounds as pus.

Slide 18

Page 19: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 19

Page 20: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 20

Page 21: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 21

Page 22: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 22

Page 23: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

You are a microbe.

You want to get into Will’s body.

Are you lucky or unlucky?

2.2 Lucky or unlucky?

Slide 23

Page 24: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

You’re with a group of salmonella bacteria in the middle of a burger.

What happens next?

2.2 Lucky or unlucky?

Slide 24

Page 25: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

You’re are a cold virus.

You drifted into Will’s nose as he breathed.

What happens next?

2.2 Lucky or unlucky?

Slide 25

Page 26: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009

You are a tetanus bacterium in the mud on Will’s football. He has a cut on his finger and he has just picked up the football.

What happens next?

2.2 Lucky or unlucky?

Slide 26

Page 27: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 27

Page 28: © Oxford University Press 2009 These microbes got in through Will’s cut finger. Left unchecked they will reproduce rapidly and fill his blood and tissues

© Oxford University Press 2009Slide 28