1. A pharmacy analyst supervises the state of a refractometer. For its calibration he needs some distilled water. The distilled water must have the following value of the refractive index:

A 1,3330

B 1,3110

C 1,3220

D 1,3440

E 1,3550

The refractive index of water at 20 °C equal to 1.3330.

2. A chemist of an analytic laboratory has to prepare turbidity standards according to the requirements of Pharmacopoeia. What substances are to be used as the reference?

A Hexamethylenetetramine and hydrazine

B Sodium chloride and calcium nitrate

C Calcium sulfate and glycerol

D Potassium chloride and barium sulfate

E Furacillin and calcium chloride

3. Specify the reaction to the ester-type drugs that is tolerated by the Ukrainian State

Reaction to the ester-type drugs is that of forming iron (III) hydr oxamates which have a bluish-red or red colour:

Pharmacopoeia:

A Formation of iron hydroxamates

B Formation of azo dye

C Formation of indophenol

D Formation of 3-bromphenol

E Formation of tayleohin

4. Presence of phenyl hydroxyl can be confirmed by the reaction with solution of:

A Iron (III) chloride solution

B Iodine alcohol solution

C Hydrochloric acid solution

D Solution of iodine in potassium iodide

E Silver nitrate solution

Presence of phenyl hydroxyl can be confirmed by the

reaction with FeCl3 solution – a violet colour is produced:

5. A pharmacist-analyst is measuring the quantity of a drug by method of indirect bromatometry. Which of the following titrated solutions is to be used?

A Sodium thiosulfate

B Calcium bromate

C Sodium edetate

D Sodium nitrite

The procedure of quantitative determination of drugs by indirect bromatometry: potassium bromide, an acid and an excess of a titrated potassium bromate solution are added to the analyte solution. The excess of bromine is determined iodimetrically:

Titrate with sodium thiosulphate, using starch solution as indicator.

E Argentum nitricum (silver nitrate)

6. What is a general method of quantitative determination of halogenides of alkaline metals?

A Argentometry

B Permanganatometry

C Nitritometry

D Chelatometry

E Alkalimetry

Argentometry allows quantitative determinate chlorides, bromides and iodides. It is based on reaction of halogenide ions with volumetric solution of silver nitrate:

Ag+ + Cl– → AgCl↓

Ag+ + Br– → AgBr↓

Ag+ + I– → AgI↓

Therefore argentometry is a general method of quantitative determination of halogenides of alkaline metals.

7. A pharmacy analyst analizes distilled water. For this purpose he brings some amount of the sample material to the boiling point, adds 0,02 M solution of potassium permanganate and diluted sulfuric acid. After 5 minutes of boiling the pink colour of the produced solution should not change. The pharmacy analyst tries to detect the following admixture:

A Chemical reducing agent

B Carbon dioxide

C Nitrates

D Sulfates

E Heavy metals

According to the State Pharmacopoeia of Ukraine the following test for oxidisable substances is carried out: to distilled water add dilute sulphuric acid and 0.02 M potassium permanganate and boil for 5 min; the solution remains faintly pink.

8. A pharmacy analyst carries out analysis of ethylmorphine hydrochloride. For determination of admixture of water by semi-micromethod he uses:

A Iodosulphurous reagent

B Hypophosphite reagent

C Methoxyphenylacetic acid

D Biuret reagent

E Molibdotangstic reagent

The semi-micro determination of water is based upon the quantitative reaction of water with sulphur dioxide and iodine in a suitable anhydrous medium in the presence of a base with sufficient buffering capacity.

9. In order to detect an admixture of potassium in medical preparations a pharmacy analyst should carry out a reaction with:

A Sodium tetraphenylborate

B Sodium tetraborate

C Boric acid

D Sulfuric acid

E Salicylic acid

Detection of potassium admixtures is based on the reaction with sodium tetraphenylborate:

After 5 min, any opalescence in the test solution is not more intense than that in the standard.

10. Select the reductant required for the determination of arsenic impurity in drugs (method 2):

Method 2 detection of arsenic impurity is based on

the reactions with hypophosphorous reagent:

A Sodium hypophosphite

B Sodium sulphite

C Potassium iodide

D Sodium hydroxide

E Hydrochloric acid

After heating on the water-bath, any colour in the test solution is not more intense than that in the standard.

11. According to the requirements of the Ukrainian State Pharmacopoeia, a pharmacy analyst is measuring iron admixture in a preparation by means of citric and thioglycolic acids. What staining indicates presence of this admixture?

A Pink

B Green

C Yellow

D Blue

E Black

Detection of iron admixtures is based on the reaction

with thioglycollic acid in the presence of citric acid solution:

After 5 min, any pink colour in the test solution is not more intense than that in the standard.

12. Due to the requirements of State Pharmacopoeia of Ukraine the analyst-pharmacist conducts identification of admixture of heavy metals (method A) with the use of reagent:

A Thioacetamide

B Sodium sulfide

C Sulfosalicylic acid

D Ammonium oxalate

Detection of admixtures of heavy metals is based on the reaction with thioacetamide reagent:

The solution acidify with hydrochloric acid solution. The substance to be examined complies with the test if any brown color in the test solution is not more intense than that in the standard solution.

E Potassium iodide

13. A pharmacy analyst carries out purity test of the drug substance "Sodium thiosulfate". Violet colour, that comes from reaction with sodium nitroprusside, indicates the presence of the following admixture:

A Specific sulfides admixture

B Sulphates admixture

C Sulfur admixture

D Sodium chloride admixture

E Iodides admixture

Sulphides admixture in sodium thiosulphate is detected with sodium nitroprusside solution:

The solution does not become violet.

14. A pharmacy analyst can verify presence of thiosulfate-ion in sodium thiosulphate by means of the following solution:

A Hydrochloric acid

B Sodium hydroxide

C Potassium sulfate

D Sodium nitrate

E Ammonium hydroxide

Sodium thiosulphate can be decomposed by hydrochloric

acid with the precipitation of sulphur (yellow) and liberation

of gas which gives a blue colour to starch iodate paper (thiosulfate-ion):

15. As main reagent in test for phosphates admixtures the Ukrainian State Pharmacopoeia recommends to use:

A Sulfomolybdenum

B Cupric tartrate

C Thioacetamide

Detection of admixtures of phosphates is based on the reaction with sulphomolybdic reagent in the presence of stannous chloride solution:

After 10 min, any blue colour in the test solution is not more intense than that in the standard.

D Acetylacetone

EHypophosphite

16. A pharmacy analyst identifies sodium hydrocarbonate. What indicator can confirm the presence of alkalescent medium reaction in the sodium hydrocarbonate solution?

A Phenolphtalein

B Starch

C Tropeolin 00

D Ferroin

E Naphtholbenzein

To water solution of sodium hydrocarbonate add phenolphthalein – pale pink color is produced (alkalescent medium reaction). Gas is evolved and the solution becomes red after heating:

17. Sodium salt, treated with hydrochloric acid and put into the colourless flame makes it:

A Red

B Brick

C Violet

D Yellow

E Green

Sodium is detected in its compounds by the characteristic yellow coloration which it imparts to colourless flame.

18. According to the requirements of the Ukrainian State Pharmacopoeia (Supplement 1), a pharmacy analyst has to carry out quantitative analysis of potassium iodide by means of the following method:

A Iodatometry

B Complexonometry

C Acidimetry

The State Pharmacopoeia of Ukraine (Supplement 1) recommends the quantitative determination of potassium iodide by iodatometric method, direct titration in the presence of hydrochloric acid. Titrate until the colour of the solution changes from red to yellow, add chloroform and titrate until the chloroform layer is decolourised, s = 2:

D Alkalimetry

E Nitritometry

19. An analyst of a pharmaceutical storehouse received the substance of hydrogen peroxide for analysis. Quantitative determination of this drug should be performed by permanganatometric method. According to the analytical normative document, titration should be carried out till the solution turns:

A Pink

B Green

C Yellow

D Dark blue

E Colourless

Quantitative analysis of hydrogen peroxide is performed by

perman ganatometric method, direct titration of an acidified hydrogen

peroxide solution with a solution of potassium permanganate untill the

titration end point is reached, i. e.

when the solution acquires a pale pink colour, S = 2,5:

20. A pharmacy analyst of an analytical laboratory carries out analysis of boric acid. Identity is confirmed by reaction of formation of methyl or ethyl borate, which on igniting has a border of flame of:

A Green сolour

B Red colour

C Violet colour

D Blue colour

E Yellow colour

Mixture of boric acid with methanol (or ethanol) and concentrated sulphuric acid is ignited, the flame with a green border is obtained:

21. A pharmacy analyst of an analytical laboratory is studying

The State Pharmacopoeia of Ukraine recommends the

borax (Na2B4O7·10H2O) according to the requirements of the Ukrainian State Pharmacopoeia. What method is recommended by the Ukrainian State Pharmacopoeia for the quantitative analysis of this preparation?

A Alkalimetry

B Iodometry

C Bromatometry

D Nitritometry

E Iodochlormetry

quantitative determination of borax by alkalimetric method, direct

titration in the presence of mannitol (sometimes can be used

other polyatomic alcohols, for example, glycerol, sorbitol etc.),

indicator – phenolphthalein:

22. An pharmacy analyst conducted the reaction of identification of mercury (II) chloride, as a result of which the red precipitate was formed. What reagent was added?

A Potassium iodide

B Sodium nitrite

C Zinc sulfate

D Magnesium of chloride

E Ammonium of bromide

Identification is carried out using general identification reactions for mercury:

Mercury (II) chloride is react with potassium iodide solution with forming

of a red precipitate, which dissolves in excess of reagent:

23. A pharmacy analyst is measuring mercury dichloride by method of indirect chelatometry. Excess of titrated solution of sodium edetate can be titrated

The quantitative determination of mercury dichloride is conducted by chelatometric method, displacement titration. At first sodium edetate solution and buffer solution pH 10.9 are added. Mercury ions form complexes with the titrant:

by means of the following titrated solution:

A Zinc sulfate

B Sodium hydroxide

C Sodium thiosulfate

D Potassium bromate

E Sodium methylate

Then mordant black, used as indicator, is added, and the excess of sodium edetate is

titrated with zinc sulphate solution until the colour changes to purple (first titration).

Then potassium iodide is added to destroy complex Hg-EDTA, and equivalent to mercuric chloride quantity of sodium edetate is titrated with zinc sulphate (second titration).

For the calculation volume of zinc sulphate solution used in the second titration is taken. Calculation is made with reference to the dried substance.

24. An analytical laboratory received

The quantitative determination of calcium gluconate is conducted by chelatometric

calcium gluconate for analysis. What method is used for its quantification?

A Chelatometry

B Bromatometry

C Iodometry

D Mercurimetric determination

E Nitritometric determination

method, direct titration using calconecarboxylic acid as indicator:

Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.

Solution is titrated until the colour changes from violet to full blue:

25. According to the requirements of the Ukrainian State Pharmacopoeia, a pharmacy analyst is determining calcium gluconate quantity by method of complexometric titration. What indicator is to be used?

A Calconcarboxylic acid

The quantitative determination of calcium gluconate is conducted by chelatometric

method, direct titration using calconecarboxylic acid as indicator:

Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.

B Methyl red

C Crystal violet

D Thymolphthalein

ETropeoline 00

Solution is titrated until the colour changes from violet to full blue:

26. According to the requirements of the Ukrainian State Pharmacopoeia, a certain drug is being measured by method of chelatometric titration. What drug is it?

A Calcium chloride

B Potassium citrate

C Potassium chloride

D Sodium benzoate

E Sodium thiosulfate

The complexometric method allows quantitative determination of substances, which contain doubly and triply charged ions of metals (such as Ca2+, Mg2+, Zn2+, Bi3+, Al3+, Hg2+, etc.).

The State Pharmacopoeia of Ukraine recommends the quantitative determination of Calcium chloride by chelatometric method, direct titration using calconecarboxylic acid as indicator:

Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.

Solution is titrated until the colour changes from violet to full blue:

27. An analytical laboratory is studying substance of calcium lactate. In presence of ammonium chloride calcium cation forms white crystalline precipitation with the following reagent:

A Potassium ferrocyanide

B Sodium chloride

C Potassium permanganate

D Sodium tetraborate

E Sodium cobaltnitrite

An official reaction for Ca2+ is that with potassium ferrocyanide solution in medium of acetic acid in the presence of ammonium chloride – a white, crystalline precipitate is formed:

28. Calcium lactate can be quantitatively determined by chelatometric method. According to the Ukrainian State Pharmacopoeia, the following substance should be used as indicator:

A Calconcarbon acid

B Diphenylcarbazone

C Naphthol benzein

According to the Ukrainian State Pharmacopoeia the quantitative determination of

calcium lactate is conducted by chelatometric method, direct titration

using calconecarboxylic acid as indicator:

Titrant is 0,1M sodium edetate, medium is strong sodium hydroxide solution.

D Phenolphthalein

E Tropeolin 00

Solution is titrated until the colour changes from violet to full blue:

29. A pharmacy analyst can verify presence of iron cation (II) in a drug formulation by means of the following solution:

A Ammonium sulfide

B Sodium chloride

C Magnesium sulfate

D Potassium bromide

E Sodium phosphate

One of the qualitative reaction of iron cation (II) is reaction with ammonium sulfide – a black precipitate is formed:

Fe2+ + (NH4)2S = FeS↓ + 2NH4+

30. An analytical laboratory has to analyze ferrous sulfate heptahydrate according to the State Pharmacopoeia of Ukraine. A test portion of the substance should be titrated with the following solution:

A Ammonium cerium sulfate

B Argentum nitrate

C Ammonium

According to the requirements of the Ukrainian State Pharmacopoeia the quantitative

determination of ferrum sulphate heptohydrate is conducted by cerimetric titration after

dissolving the preparation in the previously prepared mixture of sodium hydrogen

carbonate, water and sulphuric acid. Titrate with 0,1 M ammonium cerium nitrate

(ammonium cerium sulfate), indicator is ferroin. Solution is titrated until the red colour

disappears:

3FeSO4 + 3(NH4)2Ce(NO3)6 → Fe2(SO4)3 + Fe(NO3)3 + 3Ce(NO3)3 + 6NH4NO3

thiocyanate

D Sodium edetate

E Potassium bromate

31. An analyst is measuring sodium benzoate in the anhydrous medium by the acidimetric method according to the requirements of the Ukrainian State Pharmacopoeia. What reagent had to be used as a solvent?

A Anhydrous acetic acid

B Pyridine

C Water

D Dimethyl formamide

E Methanol

Sodium benzoate is measured by the acidimetric method in non-aqueous media (direct

titration). Anhydrous acetic acid is used as a solvent. Titrate with with perchloric acid u ntil a green colour is obtained, indicator is naphtholbenzein solution:

32. Salicylates are widely applied in medical practice as anti-inflammatory drugs. For quantitative analysis of salicylic acid the following method is applied:

A Alkalimetry

B Nitritometry

C Argentometry

D Permanganatometry

E Chelatometry

Salicylic acid is determined by alkalimetric method, direct titration. Dissolve the substance in ethanol (96 per cent), add water. Titrate with sodium hydroxide, using phenol red solution as indicator:

33. A pharmacy analyst is determining silver nitrate by thiocyanatometry method. What indicator is to be used?

Quantitative determination of silver nitrate: Thiocyanatometric titration after dissolving

the preparation in water and acidifying with dilute nitric acid, using ferric

ammonium sulphate solution as indicator until a reddish-yellow colour is obtained:

A Ferric ammonium sulphate

B Methyl orange

C Potassium chromate

D Phenolphthalein

E Starch

AgNO3 + NH4SCN → AgSCN↓ + NH4NO3

3NH4SCN + FeNH4(SO4)2 → Fe(SCN)3 + 2(NH4)2SO4

34. An analytical laboratory carries out quantitative analysis of sodium citrate by method of ion-exchanging chromatography on a cationite. What titrated solution is to be used for the following titration of generated citric acid?

A Sodium hydroxide

B Iodine

C Potassium iodate

D Hydrochloric acid

E Trilon B

The content of sodium citrate in the drug can be determined by ion-exchange

chromatography on a cationite:

Citric acid is neutralised with an alkali (NaOH), the indicator is methyl orange:

35. An analytical laboratory received substance of citric acid for the analysis. According to the requirements of the Ukrainian State Pharmacopoeia, citric acid can be determined by method of:

A Alkalimetry

B Iodometry

C Acidimetry

D Bromatometry

E Iodochlorometry

According to the requirements of the Ukrainian State Pharmacopoeia, citric acid is determined by alkalimetric method. Titrate with 1 M sodium hydroxide, using phenolphthalein as indicator.

36. In order to identify a polyatomic glycerin

Glycerin is heated with potassium hydrogen sulphate in an evaporating bowl.Vapours of acrolein are evolved which gives blue colour to the filter paper moistened

alcohol a pharmacy analyst carries out dehydration reaction with potassium hydrosulfate. The generated hereat product has a strong characteristic smell and gives blue colour to the filter paper moistened with 1% solution of sodium nitroprusside and with piperidine. What product is it?

A Acrolein

B Diethyl ether

C Acetic acid

D Ethanol

E Chloroform

with 1% solution

of sodium nitroprusside and with piperidine:

37. An analytical laboratory received "Aether anaestheticus" for analysis. What reagent should be used for detecting acetone and aldehyde impurities according to the State Pharmacopoeia of

Ukraine?

A Alkaline solution of potassium tetraiodomercurate

B Ammonium solution of argentum nitrate

C Aqueous solution of potassium iodide

D Sodium hydrosulfite solution

E Hydroxylamine solution

Admixtures of acetone and aldehydes are determined in diethyl ether (Aether anaestheticus) with alkaline potassium tetraiodomercurate solution (Nessler’s reagent). The lower layer shows only a slight opalescence:

38. In order to detect peroxides in the anesthetic ether an analytical chemist should use the following reagent:

A Potassium iodide

B Potassium chloride

C Potassium permanganate

D Sodium thiosulfate

E Sodium hydroxide

Determination of peroxides in “Aether anaestheticus”: add KI and starch solutions – no colour is produced.

H5C2–O–O–C2H5 + 2KI + H2O → I2 + H5C2–O–C2H5 + 2KOH

39. Quantitative analysis of diphenhydramine hydrochloride according to the requirements of the Ukrainian State Pharmacopoeia is carried out by alkalimetry. Which of the following titrated solutions is to be used?

A Hydrochloric acid

B Potassium bromate

C Potassium permanganate

D Sodium nitrite

E Sodium thiosulfate

The Ukrainian State Pharmacopoeia recommends determining the content of

diphenhydramine hydrochloride by alkalimety. Dissolve the substance in alcohol, add 5.0 ml o of 0.01 M hydrochloric acid. Carry out a potentiometric titration, using 0.1 M sodium

hydroxide solution. Use the volume added between the 2 points of inflexion.

40. Qualitative reaction for phenol is the reaction with bromine water. What compound is produced as a result of the interaction of phenol with bromine water and drops out as a white solid?

A 2,4,6-tribromphenol

One of the qualitative reaction of phenol is reaction with bromine water – a pale yellow precipitate of 2,4,6-tribromphenol is formed:

B 4-bromphenol

C 3-bromphenol

D 2,4-dibromphenol

E 2-bromphenol

41. An analyst of the National drug quality control inspection carries out quantitative analysis of "Resorcinol" substance by method of bromatometry (back titration). What indicator is used by doing so?

A Starch

B Ammonium iron (III) sulfate

C Potassium chromate

D Phenolphtalein

E Sodium eozinat

Resorcinol is analysed quantitatively by bromatometry (back titration). Dissolve the

substance in water; add KBr and KBrO3 solution, chloroform and hydrochloric acid.

Add KI solution and titrate with sodium thiosulphate, using starch solution as indicator.

KBrO3 + 5KBr + 6HCl → 3Br2 + 6KCl + 3H2O

Br2 + 2KI → I2 + 2KBr

I2 + 2Na2S2O3 → 2NaI + Na2S4O6

42. An analytical chemist was identifying xeroform in reaction with sodium sulphide. As a result of reaction a black solid dropped out. What ion was detected?

A Bismuth

B Lead

C Zinc

D Copper

E Silver

Xeroform (Xeroformium)

One of the qualitative reaction of xeroform is the reaction on Bi3+ with sodium sulphide

– a black ppt. is formed:

2Bi3+ + 3S2– → Bi2S3↓

43. Presence of amino group in аlanine can be confirmed by the reaction with:

A Ninhydrin solution

B Sulfuric acid solution

C Sulfosalicylic acid

Alanine is derivative of aliphatic amino acids:

And all amino acids form blue-violet coloring on heating with ninhydrin:

solution

D Sodium hydrocarbonate solution

E Barium hydroxide solution

ammonium salt of diketohydrindene ketohydrine amine

blue-violet colouring

44. In order to identify a drug an analytical chemist of the State Inspectorate for Quality Control of Medicines carries out the reaction with ninhydrin solution. Specify the drug to be identified:

A Methionine

B Cortisone acetate

C Paracetamol

D Streptocide

E Ascorbic acid

Among the presented pharmaceutical substances there is only one which is derivative of aliphatic amino acids and reacts with ninhydrin. It is Methionine (Methioninum):

The product of this reaction has a blue-violet colour, which is used for identification:

ammonium salt of diketohydrindene ketohydrine amine

blue-violet colouring

45. An analyst of a chemical laboratory conducts identification of paracetamol with the solution of iron (III) chloride. Blue-violet colour of solution appears in the presence of the following functional group:

A Phenol hydroxyl

B Aldehyde group

C Keto group

D Ester group

E Alcohol hydroxyl

Paracetamol gives the reaction with FeCI3 solution (due to the phenol hydroxyl) – a bluish-violet colouring develops:

46. For quantitative determination of paracetamol an analyst-chemist uses:

A Nitritometry

B Argentometry

C Permanganatometry

D Complexometry

E Mercurimetry

Paracetamol can be analysed quantitatively by nitritometry after preliminary acid hydrolysis, direct titration, indicator is iodine starch paper:

47. Pharmaceutical chemistry studies methods of drug synthesis. Interaction of anesthesin with beta-diethylaminoethanol in presence of sodium alcoholate with following acidation with hydrochloric acid results in origination of:

A Procaine hydrochloride

B Procainamide hydrochloride

C Tetracaine hydrochloride

D Xycain

Procaine hydrochloride (novocaine) is synthesized by the re-esterification of ethyl

para-aminobenzoate (anesthesin) with beta-diethylaminoethanol in the presence of a

sodium alcoholate (an alcoholysis reaction):

anesthesin

base of procaine

The simultaneously formed ethanol is readily distilled off because its boiling point is considerably lower than that of the diethylaminoethanol. The obtained base of novocaine is next transformed into the chloride by the action of a calculated amount of

E Trimecaine hydrochloride

an alcohol solution of hydrochloric acid.

48. Which of the mentioned below drugs has the following chemical name: n-aminobenzoic acid diethylaminoethyl ester hydrochloride:

A Novocaine

B Dimedrol

C Streptocid

D Tetracaine

E Streptomycin

Procaine hydrochloride (Procaini hydrochloridum)Novocaine (Novocainum)

According to the structural formula of novocaine we can write its chemical name: p-aminobenzoic acid diethylaminoethyl ester hydrochloride.

49. A pharmacy analyst of an analytical laboratory is studying procaine hydrochloride according to the requirements of the Ukrainian State Pharmacopoeia. What method is recommended by the Ukrainian State Pharmacopoeia for the quantitative analysis of this preparation?

A Nitritometry

B Bromatometry

C Acidimetry

D Alkalimetry

Procaine hydrochloride (Procaini hydrochloridum)Novocaine (Novocainum)

According to the requirements of the Ukrainian State Pharmacopoeia the content of procaine hydrochloride is determined by nitritometry with the indicator consisting of tropeolin-00 mixed with methylene blue or neutral red:

E Chelatometry

Carry out a blank titration.

50. According to the requirements of the State Pharmacopoeia of Ukraine, a pharmacy analyst should determine procaine hydrochloride by nitritometric method. What indicator is to be used for this purpose?

A Neutral red

B Methyl red

C Crystal violet

D Xylenol orange

E Acid chrome blue

Procaine hydrochloride (Procaini hydrochloridum)

Novocaine (Novocainum)According to the requirements of the Ukrainian State Pharmacopoeia the content of procaine hydrochloride is determined by nitritometry, using as a titrant 0,1 M sodium nitrite solution with the indicator consisting of tropeolin-00 mixed with methylene blue or neutral red:

Carry out a blank titration.

51. A pharmacist-analyst carries out quantitative analysis of procaine hydrochloride.

According to the requirements of the Ukrainian State Pharmacopoeia the content of procaine hydrochloride is determined by nitritometry, using as a titrant 0,1 M sodium nitrite solution with the indicator consisting of tropeolin-00 mixed with methylene blue

Which of the following solutions is to be used?

A Sodium nitrite

B Sodium thiosulfate

C Sodium edetate

D Potassium bromate

E Argentum nitricum

or neutral red.

52. An analyst of the National drug quality control inspection identifies "Sulfametoxazol" by adding the solutions of hydrochloric acid, sodium nitrite and beta-naphthol to the preparation. An intense red colour is observed. What functional group is identified by this reaction?

A Primary aromatic amino

B Secondary aromatic amino

C Sulpho group

D Carboxyl group

E Aldehyde group

Sulfametoxazol (Sulfametoxazolum)

Due to the presence of primary aromatic amino group sulfamethoxazol gives a reaction of diazotation with a following azo coupling. Sodium nitrite, HCl and β-naphthol are added to solution of substance and an intense red colour develops (azo dye).

53. Streptocide, sulfacyl sodium, norsulfazole or sulfadimezinum can be identified by means of the reaction to form:

A Azo dye

B Murexide

C Iodoform

D Fluorescein

Streptocide, sulfacyl sodium, norsulfazole and sulfadimezinum are sulfanylamides. The group reaction for sulfanylamides is reaction of diazotation with a following azo coupling. Sodium nitrite, HCl and β-naphthol are added to solution of substance and an intense red colour develops (azo dye).

E -

54. Quantitative analysis of drugs containing primary aromatic amine can be performed by means of nitritometric method. Which of the following preparations can be determined by the nitritometric method without preliminary acid hydrolysis?

A Sulfadimidine

B Phthalazol

C Phthazin

D Paracetamol

E Soluble streptocid

Sulfadimezine (Sulfadimezinum)

Sulfadimidine

Due to the presence unsubstituted primary aromatic amino group sulfadimezine can be analyzed by nitritometry without preliminary acidic hydrolysis.

Nitritometry, direct titration using 0,1 M NaNO2 as a titrant, indicator – internal or external. S=1.

55. A pharmacy analyst is determining one of the following drugs by the nintritometric method. What drug is it?

A Norsulfazole

B Ftivazide

C Analgin

D Ammonium chloride

E Atropine sulfate

Norsulfazole (Norsulfazolum)

Due to the presence of primary aromatic amino group sulfamethoxazol gives a reaction of diazotation with a following azo coupling. Sodium nitrite, HCl and β-naphthol are added to solution of substance and an intense red colour develops (azo dye).

56. In order to identify a drug an analytical chemist of the State Inspectorate for Quality Control performs a lignin test. Specify this drug:

A Streptocid

B Ascorbic acid

C Cortisone acetate

D Methionine

E Analgin

Lignin test is used for rapid analysis of sulfanylamides. In the result of acidic hydrolysis of lignin aromatic aldehydes are formed that react with primary aromatic amino group of sulfanylamides with a formation of Shiff bases. Solution of preparation and 1 drop of HCl is put on the paper.An orange-yellow spot develops.

57. A pharmacy has sulfonamide biseptol on sale. What chemical compounds are the main components of this

drug?

A Sulfamethoxazole, trimethoprim

B Sulfazin, salazodimethoxinum

C Sulgin, norsulfazol

D Phthalazolum, sulfadimezin

E Urosulfan, sulfapiridazin

Biseptol (Co-trimoxazole) is a combined sulfanylamide drug which contains sulfamethoxazol and derivative of diaminopyrimidine – trimethoprim.

58. After a sulfamide preparation was heated with salicylic acid in presence of concentrated sulfuric acid, it turned crimson. What drug is analyzed?

A Soluble streptocid

B Streptocid

C Sulfaguine

D Ethazol

E Phtalazol

Soluble streptocide on heating with salicylic acid in presence of concentrated sulfuric acid gives a crimson colour.

59. An expert of an analytical laboratory is determining Nitrofural. What quantitative titrimetric method can be applied?

A Iodometry

B Permanganatometry

C Alkalimetry

D Argentometry

E Nitritometry

For quantitative determination of nitrofural back Iodometry in alkaline medium is used, indicator – starch. S=1/2. The sample of preparation is dissolved on heating in water in the measuring flask in the presence of Sodium chloride. The access of 0,01N Iodine solution and alkali is added to some volume of solution. In alkaline medium Iodine forms iodide and hypoiodide:

I2 + NaOH → NaI + NaIO + H2O Iodine, which have been released after acidification is titrated by Sodium thiosulfate.

NaI + NaIO + H2SO4 → I2 + Na2SO4 + H2O I2 + 2Na2S2O3 → 2NaI + Na2S4O6

Blank titration is carried out.

61. Quantitative determination of nitrofural (furacilin) can be done by method of spectrophotometry. A pharmacy analyst can calculate quantity by measuring:

A Optical density

B Refractive index

C Rotation angle

D pH of solution

E Fusion temperature

One of the method of assay of nitrofural is spectrophotometry in 50% solution of sulfuric acid.

Spectrophotometry is a physicochemical method of analysis which is based on the determination of optical density (absorbance – A). Measured absorbance is proportional

to the pass length (b), through which radiation passes and to the concentration of substance © in solution in accordance with aquation:

62. Аnalgin substance has been sent for analysis. What method allows to evaluate quantitative content of analgin?

A Iodometry

B Acidimetry

C Alkalimetry

D Chelatometry

E Permanganatometry

Analgin (Methamizole sodium) is determined quantitatively by direct iodometry, indicator is starch. The solution of substance is acidified and then is titrated by Iodine solution to appearance of blue color, which is not disappeared during 2 minutes. S=1.

63. Which of the following reagents should be added to the isoniazid to achieve blue colour and precipitation that turns light-green and emits gases when heated?

A Copper sulfate solution

B Silver nitrate solution

C Alkaline solution

D Hydrochloric acid

Isoniazid with a solution of copper sulfate gives a blue precipitate and a blue coloration, which by subsequent heating become light green, then yellowish-green color and gas bubbles escape:

solution

E Iron (III) chloride solution

64. In course of isoniazid identification a pharmacy analyst boiled thoroughly the substance with 2,4-dinitrochlorobenzene. The substance turned yellow, after adding alkaline solution it turned first violet and then brownish-red. As a result of this reaction the following aldehyde derivative isproduced:

A Glutaconic

B Gluconic

C Glutamic

D Glyoxylic

E Hexanic

Isoniazid (Isoniazidum)

Isoniazid contains in its structure pyridine cycle, which can be determined with 2,4-dinitrochlorobenzene. The substance turns to yellow, after adding alkaline solution it turns first to violet and then to brownish-red due to formation of glutaconic aldehyde:

65. Phthorafurum is used for treatment of gastric and intestinal cancer. Fluorine in phthorafurum is detected after mineralization by the reaction with:

A Calcium chloride

BAmmonium hydroxide

C Potassium nitrate

D Sodium carbonate

Fluorafur (Phthorafurum)

Tegafur

Fluorine in phthorafurum is identified after mineralization by the reaction with CaCl2:

E Potassium chloride

white opalescence

66. According to the requirements of the State Pharmacopoeia of Ukraine, a pharmacy analyst should determine fluorouracil by method of nonaqueous titration. What titrated solution is to be used?

A Tetrabutyl ammonium hydroxide

B Sodium nitrite

C Potassium bromate

D Ammonium thiocyanate

E Sodium edetate

Pharmacopoeian method of assay of fluorouracil is alkalimetry in non-aqueous media, direct titration, indicator – thymol blue, S=1. As a titrant a solution of tetrabuthylammonium hydroxide in DMFA medium is used. Blank titration is carried out.

67. A chemist identifies ofloxacin after mineralization by the reaction of:

A fluorides

B sulphates

C arsenites

D phosphates

E sulphides

Ofloxacin is chemotherapeutic agent which belongs to the group of fluoroquinolones. It contains F- ion which can be identified after mineralization.

Ofloxacin (Ofloxacinum)

68. When the glucose is heated with the copper-tartrate reagent (Fehling's reagent) the brick-red precipitate settles down. It indicates presence of the following group:

Due to the presence of aldehyde group glucose gives a brick-red precipitate on heating with copper-tartrate reagent (Fehling's reagent):

A Aldehyde

B Ketonic

C Carboxyl

D Etherific

E Amide

69. In order to verify identity of tropan derivatives, Vitali's reaction is applied. For that purpose the medications should be first decomposed with nitric acid and then treated with alcoholic solution of potassium hydroxide and acetone. What effect will be observed?

A The solution will turn purple

B The solution will turn green

C Emission of gas bubbles

D Setting of black precipitate

E Setting of white precipitate

Vitali test: to a substance examined a fuming nitric acid is added and evaporated to dryness in a water-bath. The residue is dissolved in acetone and a solution of potassium hydroxide in methanol is added. A violet colour develops:

70. Codeine can be derived for medical purposes out of a plant alkaloid by means of semisynthetic method. Name this alkaloid:

A Morphine

B Papaverine

C Berberine

D Protopine

E Chelidonine

Codeine is opium alkaloid whiсh can be obtained by semisynthetic method from morphine:

Preparations of quinine are identified with bromine water and solution of ammonia according to formation of specific product of reaction. Name this product:

A Talleioquine

B Murexide

C Iodoform

D Ferric N-hydroxyacethamide

E Methylglyoxal

Talleioquine is a product of interaction of quinine with bromine water and dilute ammonia. In result of this reaction a green colour develops:

71. An analytical chemist determines the quantitative content of caffeine by method of acidometry in nonaqueous media in compliance with the State Pharmacopoeia of Ukraine. What solution is used as a titrant?

A Perchloric acid

B Sodium edetate

C Potassium bromate

D Sodium hydroxide

E Sodium nitrite

Non-aqueous titration in the medium of a mixture of acetic acid and acetic anhydride is used for quantification of caffeine. 0,1 M solution of perchloric acid is used as a titrant, the end-point is determined potentiometrically; S=1.

72. Theobromine and theophylline can be determined by alkalimetric method according to the substituent. What acid is to be titrated with sodium hydroxide?

A Nitric

B Chydrochloric

C Sulfuric

D Acetic

E Phosphoric

Indirect alkalimetry is used for quantitative determination of theobromine and theophylline. After addition of 0,1 M AgNO3 solution a nitric acid is formed which is titrated by 0,1 M NaOH, an indicator is bromothymol blue. S=1.

73. Solution of ephedrine hydrochloride in ampules was received for analysis in a control-analytical laboratory. One of reactions of identification of preparation is the reaction with solution

In reaction of ephedrine hydrochloride with potassium (ІІІ) ferricyanide an odour of benzaldehyde appears:

of. What appears?

A The smell of benzaldehyde

B Bubbles of gas

C Black precipitate

D The smell of ammonium

E Black colour

74. Due to the requirements of State Pharmacopoeia of Ukraine the analyst-pharmacist conducts identification of ascorbic acid with the use of reagent:

A Silver nitrate

B Zinc sulphate

C Ammonium oxalate

D Calcium chloride

E Barium nitrate

Due to the requirements of Ukrainian State Pharmacopoeia and Eur. Ph. ascorbic acid

is determined with silver nitrate solution – a dark grey precipitate is formed.

75. Analytical laboratories oten use 2,6-dichlorophenolindophenol solution, which is normally blue and can be decolourized by the reducing agents. What drug can be identified by means of 2,6-dichlorophenolindophenol solution?

A Ascorbic acid

B Salicylic acid

C Nicotinic acid

D Benzoic acid

Ascorbic acid discharges a blue colour of 2,6-dichlorophenolindophenol solution:

E Acetylsalicylic acid

76. Substance of calcium pangamate is to be studied in n analytical laboratory. Calcium cation forms a white precipitate with the following reagent:

A Ammonium oxalate

B Sodium chloride

C Potassium permanganate

D Potassium bromide

E Sodium cobaltinitrite

Calcium cation forms a white precipitate with Ammonium oxalate a white precipitate, which dissolves in mineral acids:

77. The pharmacy analyst identifies vitamins eye drops. At consideration in UV-light a bright yellowish-green fluorescence is observed. It testifies the presence of:

A Riboflavin

B Thiamine bromide

C Folic acid

D Ascorbic acid

E Vicasolum

The solution of riboflavin (vitamin B2) in the transmitted light has a pale greenish-yellow color, and in reflected light it shows an intense yellowish-green fluorescence, which disappears on the addition of mineral acids or alkali.

After adding of sodium hydrogen sulphite the fluorescence and color of the solution disappear:

78. The presence of what functional group in the molecule of pyridoxine hydrochloride gives a possibility to pass a reaction with the iron (III) chloride?

A Phenyl hydroxyl

B Carboxyl group

C Aldehydic group

D Alcoholic hydroxyl

Due to the presence of phenyl hydroxyl pyridoxine reacts with iron (III) chloride. A red colour develops.

E Pyridine cycle

79. Which of the following drugs can be quantified by an analytical chemist by ceriometry method?

A Vicasolum

B Acetylsalicylic acid

C Sodium benzoate

D Phenyl salycylate

E Phenobarbital

Ceriometry (direct titration) is used for quantitative determination of Vicasolum (vitamin K). After interaction with sodium hydroxide 2-methyl-1,4-dioxynaphthoquinone is formed, then it is reduced to 2-methyl-1,4-dioxynaphthalin, which is titrated with 0,1 M cerium sulphate to green colour (the indicatior is ferroine).

S=1/2.

80. An analytical laboratory received "Adrenalini tartras" substance for analysis. According to the requirements of the Ukrainian State Pharmacopoeia, quantitative analysis of this substance can be carried out by method of:

A Acidimetry in non-aqueous medium

B Acidimetry in aqueous medium

C Iodometry

D Nitritometry

E Bromatometry

According to the requirements of the Ukrainian State Pharmacopoeia, quantitative analysis of Adrenaline tartrate is carried out by acidimetry in non-aqueous medium using as a titrant 0,1 M perchloric acid solution, indicator is crystal violet. S=1.

81. A pharmacist-analyst is measuring the quantity of an adrenaline tartrate substance by method of

According to the requirements of the Ukrainian State Pharmacopoeia, quantitative analysis of Adrenaline tartrate is carried out by acidimetry in non-aqueous medium using as a titrant 0,1 M perchloric acid solution, indicator is crystal violet. S=1.

acid-base titration in nonaqueous solvents. Which indicator is to be used in this case according to the requirements of the Ukrainian State Pharmacopoeia?

A Crystal violet

B Methyl orange

C Phenolphtalein

D Thymolphthalein

E Eriochrome black

82. According to the State Pharmacopoeia of Ukraine, in order to test a substance for the highest level of magnesium impurities an analytical chemist must use the following solution:

A Hydroxyquinoline

B Resorcin

C Pyridine

D Formaldehyde

E Benzaldehyde

Magnesium impurities are determined by reaction with 8-hydroxyquinoline in chloroform. An intense yellow colour of solution must be not more intense than of reference (standart) solution.

83. In order to identify ouabain (strophanthine G), a drug from the group of cardiac glycosides, an analytical chemist must prove the presence of a steroid cycle. What acid should be used as a reagent?

A Sulfuric

B Oxalic

Ouabain (strophanthine G)belongs to the group of cardiac glycosides. Cardiac glycosides have in their base a steroid cycle, which is determined by the reaction with sulfuric acid.

C Citric

D Formic

E Chromotropic

84. The basic structure of steroid hormones is hydrocarbon skeleton - cyclopentane perhydrophenanthrene.

What natural compound is used for testosterone propionate production?

A Cholesterol

B Indole

C Naphthalene

D Phenanthrene

E Anthracene

Testosterone propionate (Testosteroni propionas)

Testosterone is an androgen steroid hormone. In the body the cholesterol is used for its production.

85. An analytical chemist working at a pharmacy identifies oxacillin sodium salt. As a reagent he uses hydroxylamine hydrochloride solution in presence of sodium hydroxide solution and copper nitrate solution. What structural fragment of a drug molecule can be detected by means of these reagents?

A Beta-lactam cycle

B Thiazolidine cycle

C Isoxazole cycle

D Furan cycle

E Thiadiazole cycle

Oxacillin sodium belongs to β-lactam antibiotics. Due to the presence of β-lactam cycle it reacts with hydroxylamine hydrochloride solution in presence of sodium hydroxide solution and copper or iron salts. In case of formation of copper penicillino-hydroxamate a green colour develops, when iron penicillino-hydroxamate is formed a red colour develops:

86. A base of the structure of tetracycline is partly hydrated ring of:

A Naphthacene

B Naphthalene

C Acridine

D Phenanthrene

E Anthracene

A partly hydrated naphthacene (tetracene) ring is in the base of tetracycline.

Tetracycline (Tetracyclinum)