01 course introduction.halogen. of alkaline metals

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    LECTURE 1Theme: Course introduction and

    importance of Pharmaceutical Chemistry

    for pharmaceutical analysis. Introductionabout Pharmacopoeia and methods ofdrug analysis.

    Inorganic drugs from group ofhalogenides of alkaline metals.

    Associate prof. Mosula L.M.

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    The plan1. A subject and the contents of pharmaceutical chemistry, its

    interrelation with chemical, medical and biologic and

    pharmaceutical disciplines.2. The State Pharmacopoeia of Ukraine (SPU), the International

    (Ph. Int.), Europian (Ph. Eur.) and British Pharmacopoeias (BP),

    and other analytical normative documentation (AND), which

    regulates high quality of pharmaceutical preparations.

    4. Classification of drugs.

    5. Inorganic drugs from group of halogenides of alkaline metals:

    obtaining, properties (appearance and solubility), identification,

    tests, assay, storage, action and use of preparations of:

    Fluorine (sodium fluoride);Chlorine (sodium and potassium chlorides);

    Bromine (sodium and potassium bromides);

    Iodine (sodium and potassium iodides).

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    Pharmaceutical chemistry is a highly interdisciplinary sciencecombining organic chemistry with biochemistry, inorganic chemistry, analyticalchemistry, pharmacology, pharmacognosy, molecular biology and physical

    chemistry.Pharmaceutical chemistry is the chemistry of drugs and

    pharmaceutical products.

    The aim of pharmaceutical chemistry is the discovery anddevelopment of new therapeutic agents.

    The mission of the Pharmaceutical Chemistry course is tointroduce the structure, properties, and analysis (both qualitative andquantitative) of pharmaceutical agents as well as the fundamental techniquesused for near patient testing in clinical laboratories to the students. Topicsinclude some of the basic concepts in pharmaceutical chemistry as well as

    methods of pharmaceutical analysis such as 1) the drug synthesis, 2) review oforganic functional groups found in drug molecules as well as cations and anionsof the inorganic drugs, 3) physicochemical properties related to drug action, 4)physicochemical and chemical analysis of drugs, 5) methods of identification ofpharmaceutical agents, 6) the storage conditions and use of drugs.

    http://en.wikipedia.org/wiki/Organic_chemistryhttp://en.wikipedia.org/wiki/Biochemistryhttp://en.wikipedia.org/wiki/Computational_chemistryhttp://en.wikipedia.org/wiki/Pharmacologyhttp://en.wikipedia.org/wiki/Pharmacognosyhttp://en.wikipedia.org/wiki/Molecular_biologyhttp://en.wikipedia.org/wiki/Physical_chemistryhttp://en.wikipedia.org/wiki/Physical_chemistryhttp://en.wikipedia.org/wiki/Physical_chemistryhttp://en.wikipedia.org/wiki/Physical_chemistryhttp://en.wikipedia.org/wiki/Molecular_biologyhttp://en.wikipedia.org/wiki/Pharmacognosyhttp://en.wikipedia.org/wiki/Pharmacologyhttp://en.wikipedia.org/wiki/Computational_chemistryhttp://en.wikipedia.org/wiki/Computational_chemistryhttp://en.wikipedia.org/wiki/Biochemistryhttp://en.wikipedia.org/wiki/Organic_chemistry
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    Pharmaceutical Chemistry is a multifaceted discipline that

    encompasses synthetic organic chemistry, inorganic, analytical,

    physical, colloidal, biological chemistry and some disciplines of

    medical and biological profile: biology, normal and pathologicalphysiology, microbiology. The pharmaceutical chemistry is closely

    connected with other profile disciplines: pharmacognosy, technology

    of medicines, the organisation and pharmacy economy,

    pharmacotherapy.

    Pharmaceutical chemistry is a discipline at the intersection of

    chemistry andpharmacology involved with designing, synthesizing

    and developingpharmaceuticaldrugs.

    Compounds used as medicines are overwhelmingly organic

    compounds including small organic molecules and biopolymers.

    However, inorganic compounds and metal-containing compounds

    have been found to be useful as drugs.

    http://en.wikipedia.org/wiki/Chemistryhttp://en.wikipedia.org/wiki/Pharmacologyhttp://en.wikipedia.org/wiki/Drug_designhttp://en.wikipedia.org/wiki/Organic_synthesishttp://en.wikipedia.org/wiki/Pharmaceuticalhttp://en.wikipedia.org/wiki/Medicationhttp://en.wikipedia.org/wiki/Organic_compoundshttp://en.wikipedia.org/wiki/Organic_compoundshttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Biopolymerhttp://en.wikipedia.org/wiki/Biopolymerhttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Small_moleculehttp://en.wikipedia.org/wiki/Organic_compoundshttp://en.wikipedia.org/wiki/Organic_compoundshttp://en.wikipedia.org/wiki/Organic_compoundshttp://en.wikipedia.org/wiki/Medicationhttp://en.wikipedia.org/wiki/Pharmaceuticalhttp://en.wikipedia.org/wiki/Organic_synthesishttp://en.wikipedia.org/wiki/Drug_designhttp://en.wikipedia.org/wiki/Pharmacologyhttp://en.wikipedia.org/wiki/Chemistry
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    Pharmacopoeiain its modern technical sense, is a book containingdirections for the identification of samples and the preparation of compoundmedicines, and published by the authority of a government or a medical orpharmaceutical society.The word derives fromAncient Greek (pharmakopoieia),from -(pharmako-) 'drug', followed by the verb-stem -(poie-)'make' and finally the abstract noun ending - (-ia). These three elementstogether can be rendered as 'drug-mak-ing'.

    The aim of theInternational Pharmacopoeia (Ph. Int.), which is issuedby the World Health Organization as a recommendation, is to achieve a wideglobal uniformity of quality specifications for selected pharmaceutical products,excipients, and dosage forms. The information published in the InternationalPharmacopoeiais collated via a consultative procedure and is based on

    international experience, the monographs being established in an independentmanner. Priority is given to medicines that are widely used throughout theworld. High priority is accorded to medicines that are important to WHO healthprograms, and which may not appear in any other pharmacopoeias.

    http://en.wikipedia.org/wiki/Medicinehttp://en.wikipedia.org/wiki/Pharmaceuticalhttp://en.wikipedia.org/wiki/Ancient_Greekhttp://en.wikipedia.org/wiki/World_Health_Organizationhttp://en.wikipedia.org/wiki/Monographhttp://en.wikipedia.org/wiki/Medicineshttp://en.wikipedia.org/wiki/Pharmacopoeiahttp://en.wikipedia.org/wiki/Pharmacopoeiahttp://en.wikipedia.org/wiki/Medicineshttp://en.wikipedia.org/wiki/Monographhttp://en.wikipedia.org/wiki/World_Health_Organizationhttp://en.wikipedia.org/wiki/Ancient_Greekhttp://en.wikipedia.org/wiki/Pharmaceuticalhttp://en.wikipedia.org/wiki/Medicine
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    The European Pharmacopoeia (Ph. Eur.) of the Council of Europe is apharmacopoeia, listing a wide range ofactive substances and excipients used toprepare pharmaceutical products in Europe[citation needed]. The 2005 editionincludes 1800 specific and general monographs, including various chemical

    substances, antibiotics, biological substances. The European Pharmacopoeia isdeveloped by the European Directorate for the Quality of Medicines (EDQM) andis a part of the Council of Europe, Strasbourg, France. It has been created by theConvention on the elaboration of a European Pharmacopoeiafrom 1964.

    The British Pharmacopoeia(BP)is an annual published collection of qualitystandards for UKmedicinal substances. It is used by individuals andorganizations involved in pharmaceutical research, development, manufactureand testing. Pharmacopoeial standards are publicly available and legallyenforceable standards of quality for medicinal products and their constituents.The Pharmacopoeia is an important statutory component in the control of

    medicines which complements and assists the licensing and inspection processesof the Medicines and Healthcare products Regulatory Agency (MHRA) of theUnited Kingdom. Pharmacopoeial standards are compliance requirements; thatis, they provide the means for an independent judgment as to the overall qualityof an article and apply throughout the shelf-life of a product. Inclusion of asubstance in a pharmacopoeia does not indicate that it is either safe or effective

    for the treatment of any disease.

    http://en.wikipedia.org/wiki/Council_of_Europehttp://en.wikipedia.org/wiki/Pharmacopoeiahttp://en.wikipedia.org/wiki/Active_substancehttp://en.wikipedia.org/wiki/Excipientshttp://en.wikipedia.org/wiki/Pharmaceuticalhttp://en.wikipedia.org/wiki/Europehttp://en.wikipedia.org/wiki/Wikipedia:Citation_neededhttp://en.wikipedia.org/wiki/Monographhttp://en.wikipedia.org/wiki/Antibioticshttp://en.wikipedia.org/wiki/European_Directorate_for_the_Quality_of_Medicineshttp://en.wikipedia.org/wiki/Council_of_Europehttp://en.wikipedia.org/wiki/Strasbourghttp://en.wikipedia.org/wiki/United_Kingdomhttp://en.wikipedia.org/wiki/Medicinalhttp://en.wikipedia.org/wiki/Pharmacopoeiahttp://en.wikipedia.org/wiki/Medicines_and_Healthcare_products_Regulatory_Agencyhttp://en.wikipedia.org/wiki/Medicines_and_Healthcare_products_Regulatory_Agencyhttp://en.wikipedia.org/wiki/Pharmacopoeiahttp://en.wikipedia.org/wiki/Medicinalhttp://en.wikipedia.org/wiki/United_Kingdomhttp://en.wikipedia.org/wiki/Strasbourghttp://en.wikipedia.org/wiki/Council_of_E

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