03-05 w. w. norton 02-11ab 02-28 02-29 adapted from kandel, e.r. schwartz, j.h., and jessell, t.m....
TRANSCRIPT
W. W. Norton
W. W. Norton
W. W. Norton
Ada
pted
fro
m K
ande
l, E
.R. S
chw
artz
, J.H
., an
d Je
ssel
l, T
.M. (
Eds
.), P
rinc
iple
s of
Neu
ral S
cien
ce, 3
rd
edit
ion.
Nor
wal
k, C
onne
ctic
ut: A
pple
ton
& L
ange
, 199
1. C
opyr
ight
© 1
991
by A
pple
ton
& L
ange
.
Important Neurotransmitters
endorphinacetylcholinedopaminenorepinephrineserotoninGaba
Endorphin
Relieves pain
Responsible for “joggers high”
Acetylcholine
Important in memory
Transmitter in the hippocampus
Transmitter at the neuro-muscularjunction.
Acetyl CoA + Choline
Acetylcholine
notes: Vitamin B5 makes up part of Acetyl CoA.
curare (a dart poison) blocks acetylcholine
Dopamine
There is too little in Parkinson disease
There is too little in tardive dyskinesia
Norepinephrine
There is too little in depression
Increases alertness
Tyrosine
L-dopa
dopamine
norepinephrine
Phenylalanine
W. W. Norton
MAO = monoamine oxidase
MAO Breaks down:
dopaminenorepinephrineserotonin
An MAO inhibitor prevents the breakdownof these neurotransmitters.
Serotonin
Controls sleep onset
There is too little in depression
Affected by the prescriptiondrugs prosac and zoloft
tryptophan
serotonin
GABAGABA
Valerian root affects GABA
GABA is available as afree from amino acid
Can act as a tranquilizer
Prescription