PHYTOBIOACTIVESCERNILYS®

patent application

in progressANTI-DARK CIRCLES FOR A SUBLIME LOOK

COMPOSITION

COSMETIC PROPERTIES

CERNILYS® = ANTI-DARK CIRCLE ACTIVE- Decongestant action- Decrease in hyper-vascularization- Soothing activity- Reduction of pigmentation

Sugars (polysaccharides: mainly galactomannan and sulfated arabinogalactan) Polyphenols (catechic derivates)

Dark circle is a common esthetical problem giving a tired look. This is an important sign of fatigue and it can also refl ects a poor health.Cause of dark circle is multifactorial. Skin under-eye is very thin and so is extremely sensitive to external stress (as UV, smoke, lack of sleep...). Thus, this area is very sensitive to free radicals attack and can easily present infl ammation. Also, this region is excessively vascularized and can suffer from a lack of blood circulation and tone. All these factors induce an increase in red and blue tones, a decrease in skin luminosity and in turn bring this particular dark coloration under the eye...CERNILYS® has been specifi cally developed to act on all factors inducing dark circle. Actually, various tests have proven its activities on circulation: it increases vascular tone and decreases excessive vascularization to reduce oedema and redness. Also, investigations showed anti-oxidant and anti-infl ammatory effects to sooth skin and reduce redness too. Finally, clinical trials demonstrated that CERNILYS® decreases red and blue tones and increases skin luminosity under the eye. Therefore, CERNILYS® is a complete anti-dark circle active for effi cient eye contour care. CERNILYS® does not hide dark circles as classic concealer but really reduces them.

• INCI NAME (suggested): Cedrus Atlantica Bark Extract

CHINA authorized

ACTIVITIES AND EFFICACY

In vitro test - STIMULATION OF VASOCONSTRICTIONPredictive assay

CERNILYS® decreases bluish-red colour and reduces oedema. CERNILYS® reduces puffy eyes and dark colour under the eye.

1- Pre-screen: Selection of actives with molecules reported to exert a protective effect on vascular system.2- Screening by Transcriptomic analysis: Selection of actives that target genes involved in the regulation of vascular tone and angiogenesis.

CERNILYS® increases EndoThelin-1 gene expression (ET-1), a potent vasoconstrictor peptide. CERNILYS® improves vascular tone and eliminates blood stagnation.

CERNILYS® increases ThromboSPondin-1 (TSP-1) gene expression, an endogenous inhibitor of angiogenesis. CERNILYS® restricts formation of blood vessels. CERNILYS® reduces excessive vascularization under the eye

CERNILYS® counteracts oxidative stress and infl ammation induced from various assaults in the vulnerable area around the eyes. CERNILYS® allows vascular protection and reinforcement and so decreases vascular leakage. CERNILYS® reduces oedema and puffy eyes. CERNILYS® prevents alterations in red blood cells and so prevents blood pigments liberation and accumulation. CERNILYS® decreases bluish-red colour.

in vitro

In vitro testSOOTHING ACTIVITY

In vitro testANTIOXYDANT ACTIVITY

CLINICAL EVALUATION - CERNILYS® 3%

(28 days - 20 volunteers - twice daily use - serum for eye contour - hemi-face)

VISUALIZATION

Average reduction of dark circles: -35%

Increase in Luminosity Decrease in Redness Decrease in blue-tone

CERNILYS® brightness about 4 times more than placebo.

CERNILYS® decreases redness 3 times more than placebo.

CERNILYS® decreases blue-tone 10 times more than placebo.

in vivo

AUTO EVALUATION

More than 60% of volunteers observed a remarkable improvement in their eye contour area with CERNILYS®.The eyes look brighter, fresh and energized.

PHYTOBIOACTIVESCERNILYS®

3 Eye concealer

3 Anti-dark circles product

3 Eye contour care

COSMETIC USES

CHARACTERISTICS Organoleptic: Appearance: liquid Colour: Light amber to brown Odour: Characteristic

Solubility: Water: Soluble (10%) Ethanol: Partially soluble (10%)

STORAGE Store protected from light in their original packaging and at room temperature (15-25°C).

TECHNICAL DATA

Biopôle Clermont-Limagne - 63360 St Beauzire - FranceTel: +33 4 73 33 99 00 E-mail: greentech@greentech.frFor Germany: info@greentechgmbh.deFor USA: mmueller@greentechusainc.comWeb site: www.greentech.fr________________________________________________________________________

E d i t i o n s M a r c h 2 0 1 4

• USE LEVEL: 3 %

• pH LEVEL: 4.0 to 10.0

• CAUTION FOR USE: Add at the end of preparation, at 35-40°C for emulsions, while cooling.

FORMULATIONS

Warning: The company cannot assume any liability or risk involved in the use of its products since the conditions of use are beyond our control. We assume no responsibility concerning the formulations which are brought to the market and which contain one or several of our products. It is incumbent to the formulators to take all necessary precautions and, in particular, to comply with all required legal and regulatory steps and formalities.

CERNILYS®:- Has decongestant action- Decreases hypervascularization- Reduces infl ammation- Decreases pigmentation

Anti-dark circles action

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