05/02/2018 imaging characterization of ultra-wide field ar ...williams, d. r. (2003). subjective...

11
MAJOR RESULTS: Lens had consistent performance out until 87 deg. As expected, the lens performed worse at the edges of the field than towards the middle. Due to constraints of the mount of the lens, no information was available from 87-120 deg. which could have informed to the decay of the resolution. GOAL/OBJECTIVE: To design an application-specific, field-varying resolution classification of the fisheye camera lens for use in a VR/AR video streaming system. TEST: Rotated the lens around L-shaped target and conducted slanted edge MTF tests at various points in the field. Record resolution data across the entire FOV at specific locations in equally weighted circles around the field. Took 11 rho rotation measurements at the angles across 8 symmetrical theta rotations every 45°. Total: 88 total measurements. Participants: Barry Magenya (Project Coordinator), Mike Brunsman (Customer Liaison), Mitch Soufleris (Scribe), Aaron Michalko (Faculty Advisor); Customer: Raptor Vision LLC Imaging Characterization of Ultra-Wide Field AR/VR Lenses 05/02/2018 1 Front and Back views of final test set-up (above). r 1 0 r 2 45 r 3 54 r 4 75 r 5 87 r 6 120 Diagram of measurements across field and angles at which measurements will be taken (below). From left to right: Entaniya fisheye lens with 280° field of view, Pixelink PL-E533CU camera and circuit board and sensor. Read the full report: http://www2.optics.rochester.edu/workgroups/knox/myweb/OP T310.html

Upload: others

Post on 22-Jul-2020

3 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:• Lenshadconsistentperformanceoutuntil87deg.• Asexpected,thelensperformedworseattheedgesofthe

fieldthantowardsthemiddle.• Duetoconstraintsofthemountofthelens,no

informationwasavailablefrom87-120deg.whichcouldhaveinformedtothedecayoftheresolution.

GOAL/OBJECTIVE:Todesignanapplication-specific,field-varyingresolutionclassificationofthefisheyecameralensforuseinaVR/ARvideostreamingsystem.

TEST:RotatedthelensaroundL-shapedtargetandconductedslantededgeMTFtestsatvariouspointsinthefield.RecordresolutiondataacrosstheentireFOVatspecificlocationsinequallyweightedcirclesaroundthefield.• Took11rhorotationmeasurementsattheanglesacross8

symmetricalthetarotationsevery45°.• Total:88totalmeasurements.

Participants:BarryMagenya (ProjectCoordinator),MikeBrunsman (CustomerLiaison),MitchSoufleris (Scribe),AaronMichalko (FacultyAdvisor);Customer:RaptorVisionLLC

Imaging Characterization of Ultra-Wide Field AR/VR Lenses

05/02/2018

1

FrontandBackviewsoffinaltestset-up(above).

r1 0r2 45r3 54r4 75r5 87r6 120

Diagramofmeasurementsacrossfieldandanglesatwhichmeasurementswillbetaken

(below).

Fromlefttoright:Entaniya fisheyelenswith280°fieldofview,Pixelink PL-E533CUcameraandcircuitboardandsensor.

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/OPT310.html

Page 2: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

APPLICATION:MATLABVIStoolcapabilitiesinclude• ProducearetinalimageusingZernikecoefficientsfromapatient.• Accountsforapodization oftheeyetomimictheStiles-Crawfordeffect

attheretina.• ProduceapolychromaticPSFusedtoproduceanRGBimage.• Accountsforthetoric natureofthecorneabyallowingtheuseofan

elliptical-pupilfunction.• ProvidesimagequalitymetricsincludingtheVisualStrehl Ratio.• ComputesanABCDmatrixbasedontheDiazpapertofindthe

effectivefocallengthofthecrystallinegradientindexoftheeye.

References:Abraham,Chandler.“ABeginner'sGuideto(CIE)Colorimetry–ColorandImaging–Medium.”Medium,AugmentingHumanity,10Sept.2016,medium.com/hipster-color-science/a-beginners-guide-to-colorimetry-401f1830b65a.Campbell,F.W.,&Green,D.G.(1965).Opticalandretinalfactorsaectingvisualresolution.JournalofPhysiology,181,576-593.Gobbi,PierGiorgio.“ModelingtheOpticalandVisualPerformanceoftheHumanEye”,SPIEPress.2013Huang,Yanqiao.“HumanLensModelingandBiometricMeasurementTechnique.”DepartmentofBiomedicalEngineering,UniversityofRochester.2008.http://hdl.handle.net/1802/6275Iskander,D.Robert,etal.“ObjectiveRefractionfromMonochromaticWavefrontAberrationsviaZernikePowerPolynomials.”OphthalmicandPhysiologicalOptics,vol.27,no.3,2007,pp.245–255.,doi:10.1111/j.1475-1313.2007.00473.x.J.A.Díaz,“ABCDmatrixofthehumanlensgradient-indexprole:applicabilityofthecalculationmethods,”Appl.Opt.47,195–205(2008).APOPAI0003-6935http://dx.doi.org/10.1364/AO.47.000195KresimirMatkovic.ToneMappingTechniquesandColorImageDierenceinGlobalIllumination.2003L.N.Thibosetal,"Accuracyandprecisionofobjectiverefractionfromwavefrontaberrations,"JournalofVision,vol.4,(4),pp.329,2004.Lindbloom,BruceJustin.“RGB/XYZMatrices.”BruceLindbloom'sWebsite,7Apr.2017,www.brucelindbloom.com/index.html?Eqn_RGB_XYZ_Matrix.html.Schwiegerling,Jim."Scalingpseudo-Zernikeexpansioncoecientstodierentpupilsizes,"Opt.Lett.36,3076-3078(2011)StuartRussellandPeterNorvig.2009.ArticialIntelligence:AModernApproach(3rded.).PrenticeHallPress,UpperSaddleRiver,NJ,USA.Watson,AndrewB.“ComputingHumanOpticalPointSpreadFunctions.”JournalofVision,TheAssociationforResearchinVisionandOphthalmology,1Feb.2015,jov.arvojournals.org/article.aspx?articleid=2213266.Williams,D.R.(2003).Subjectiveimagequalitymetricsfromthewaveaberration.Paperpresentedatthe4thInternationalCongressofWavefrontSensingandAberration-FreeRefractiveCorrection,SanFrancisco,CA.

GOAL:Todevelopadigitalvisualizationimagesimulation(VIS)tooltosimulatehowapatient’seyeswillperforminaroutineeyeexam.

OBJECTIVE:VIStoolwillaidinprovidingaccurateprescriptionsforeyecarewhilereducingthetime,cost,andhumanerrorcurrentlyassociatedwiththecommonexamroutine.

Improved Method of Estimating Required Vision Correction05/04/2018

2

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/vision-FinalDDD.pdf

Participants:AliHashim (ProjectCoordinator),DiegoMartinez(CustomerLiaison),PerryWang(DocumentHandler),Weidi Liu (Scribe),Dr.JenniferHunter(FacultyAdvisor);Customer:DigitEyez

PSFfoundusingperfectlenswasmodeledwithhard-codedZernikecoefficientsusingCodeV(left)andusingMATLABVIStool(right)toconfirmconsistencyoftheVIStool.BothPSFsareinvertedduetonegativemagnification.

Page 3: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:• Designandbuildaninitialstaticprototype.• Futureplansincludeintegratingamechanical

componentthatwillallowforrotationtoimageatmultipleangles,findingafluidforthefluoroscopyprocedure,anddesigningaswitchprogramtoallowformoreeffectiveimaging.

GOAL:Todesignanearinfrared(NIR)imagingsystemprototypethatcanbeusedinsurgicalsimulationstoaccuratelyreplicatethecurrenttechnologyofx-rays.

OBJECTIVE:Thisprojectwillallowsurgeonstoperformpracticesurgeriesinasaferenvironmentandcouldleadtoahigherrateofsuccess.

TEST:Testedtheprototype'sperformancemetrics:• MTFmeasurementtotesttheresolutionquality.• Spotdiagramstotesttheoff-axisquality.

Also,conductedasamplematerialstudytoanalyzetheeffectofsolutionsinvaryingconcentrationsandtheperformancewithvaryingsettings.

Safe Near-Infrared Surgical Trainer for Urologists05/06/2018

3

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/trainer-DDDTeamTrainerFINAL.pdf

Participants:KatieArmstrong(ProjectCoordinator),NoraLane(CustomerLiaison),Chih-Hsuan Tsao(DocumentHandler),JosephKelly(Scribe),Dr.GregSchmidt(FacultyAdvisor)

Customer:URUrology/Dr.AhmedGhazi

Opticaldesignoftheprototypesetup(above).

Bartargetandneedleinbetweentwolayersof40%Dimethylsulfoxidesamplewithskinlayerontop(right).

Page 4: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

Schematicsoftheopticalprojection.Note:Agratingisprojectedontotheimageplane(below).

MAJORRESULTS:• Presentedaverticallyalignedprototypesystemtoshow

proofofconcept.• Capturedanimageandmanuallyranitthroughprogramto

producea3Dmodelwiththequantitativedatafortheheight,lengthandwidthofthebump.

GOAL:ToimproveaccuracyoftheskintestwithPurifiedProteinDerivative(PPD),thecurrentmeasuringmethodforLatentTuberculosis,viaannovelopticsystemthatwouldcalculatethesurfacetopographyoftheblebafterinjection,andprovideavolumemeasurement.

OBJECTIVE: Toeliminatesubjectivity/amountofhumanerrorassociatedwiththecurrenttest.

TEST:DevelopedaMATLABprogramtoperformFouriertransform,andphaseunwrappingontheimages.Numericaldatawasextractedfromtheshiftsofthelinepatternwhichiscalculatestheheightandwidthofthereactionbump.

Also,conductedin-vivoimagetestingonaraisedskinmoleunderdifferentcolorLEDlighttovalidatetheirdesignandtesttheMATLABcodeprocessing.

Optical Metrology of Skin Bumps in Tuberculosis Testing05/06/2018

4

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/TBFinalDDD.pdf

Participants:SzeWah Lee(ProjectCoordinator),RebeccaSilver(CustomerLiaison),CocoYang(DocumentHandler),MadilynBeckman(Scribe),YiWenFan(CodingExpert),AndrewBerger(FacultyAdvisor)

Customer:RNTorres

Finalpresentedsystemsetup(above).

References: 1.Mathematic Theory: Tavares, Paulo J., and Mario A. Vaz. “Linear Calibration Procedure for the Phase- to-Height Relationship in Phase Measurement Profilometry.” Optics Communications, vol. 274, no. 2, 2007, pp. 307–314. 2007.02.038. 2. Polarizer Theory: Anderson, R. Rox. “Polarized Light Examination and Photography of the Skin.” JAMA Internal Medicine, American Medical Association, 1 July 1991. 3.Camera: https://www.theimagingsource.com/products/industrial-cameras/firewire-400-monochrome/dmk31bf03/ 4.Collimating Lens: https://www.edmundoptics.com/optics/optical-lenses/double-convex-dcx-spherical-singlet-lenses/15mm-dia.-x-20mm-fl-uncoated-double-convex-lens/ 5.Doublet: https://www.edmundoptics.com/optics/optical-lenses/double-convex-dcx-spherical-singlet-lenses/15mm- dia.-x-20mm-fl-uncoated-double-convex-lens/

Page 5: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:Designeda“invisibleglass”prototypeandwasabletodemonstratetothepublic.

Futureideasincludethepotentialofaddinglasersandcolorforincreasedentertainmentasafinalizedexhibit.

GOAL:Tocreatean“invisibleglass”prototypeexhibitfortheRochesterMuseum&ScienceCenterasaproofofconcept.

OBJECTIVES:TocommemorateKatherineBlodgett’sworkonantireflectivecoatingsandtobeanentertainingandeducationalexhibittothegeneralpublicofallages.

CONCEPT:Creationof“invisibleglass”exhibit• Developmethodforpreventingthetwoliquidsfrom

mixingwhentheglasspieceisusedconsistentlyoveralargeperiodoftimewithpotentialforce.

• Testvariousrefractiveindicestodeterminewhatrefractiveindicessatisfactorilycausestheglasspiecetobecome“invisible.”

• Tocreateacaptionforthedisplaythatoffersasimpleyetinformativeexplanationoftheprocessesathand.

“Invisible Glass” Museum Prototype Exhibit05/04/2018

5

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/rmsc-DDD_Museum_Final.pdf

Participants:HaleyKnapp(ProjectCoordinator),Zilong Li(CustomerLiaison),StephenChess(DocumentHandler,Scribe),DuncanMoore(FacultyAdvisor)Customer:RochesterMuseum&ScienceCenter

References:1.Whelan,M.,andDr.EdwinReilly.“KatharineBurrBlodgett.”KatharineBurrBlodgett- EngineeringHallofFame,EdisonTechCenter,2014,www.edisontechcenter.org/Blodgett.html.2.“IrvingLangmuirandKatharineBurrBlodgett.”ChemicalHeritageFoundation,30Oct.2015,www.chemheritage.org/historical-profile/irving-langmuir-and-katharine-burr- blodgett.3.Majewski,Janice.“SmithsonianGuidelinesforAccessibleExhibitionDesign.”SmithsonianInstitution,SmithsonianAccessibilityProgram,www.si.edu/Accessibility/SGAED#page_21.4.Nave,R.“RefractionofLight.”RefractionofLight,GeorgiaStateUniversity,hyperphysics.phy-astr.gsu.edu/hbase/geoopt/refr.html.

Page 6: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

DemonstrationoftheMATLABreconstructiontool(left).

MAJORRESULTS:• Developedareconstructionalgorithmsforanimported

imageatdifferentdefocuspositionstakenfromtheplenoptic systeminZEMAX.

• Futureworkincludescreatinganalgorithmtocharacterizethesystemdesign,generatingthePSFforimageswithchangingf/#,pixelsize,orotherinputs,andupdatingthescripttodeterminetheboundsofthereconstruction.

GOALS:• Topresentatradestudyofaplenoptic systemwith

regardtomicrolens dimensions,sensortype,andimagespacef/#.

• ToprovidetheimagereconstructiontoolstoimplementNavitar’s plenoptic lenssystem.

CONCEPT:Aplenoptic imagingreliesonasetofmicrolensesinfrontofthesensor.Eachsetofpixelsbehindthemicrolenses makesupamicrolens array.

Themicrolens arrayprovidesadirectionalitycomponentoflight,whichallowsreconstructionoftheimagetodifferentdefocusdepths.However,thereisalossinresolutionthatreconstructstheimagemustaveragesoutamicrolens arraytobeonepixel.

Methodology for Processing Plenoptic System Images05/04/2018

6

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/pleno-DDDFinal- TeamPleno.pdf

Participants:WenZhou(ProjectCoordinator),StephenWatson(CustomerLiaison),Xiaojing Huang(DocumentHandler),Weichen Yao(Scribe),Dr.ScottCarney(FacultyAdvisor)

Customer:Navitar

Page 7: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

Threemonolithicfreeformtelescopedesigns(below).

MAJORRESULTS:• Concludedtheshapeandqualitativepropertiesofthe

focusspots(asshownabove)werestronglycorrelatedandsupportedtheproposedMSFmodel.

• Confirmedtheproposedmodelwithempiricalthrough-focusspotmeasurements.

• Addressedthetolerancing andsensitivityanalysis.

GOAL:TounderstandandmodelhowMid-SpatialFrequency(MSF)erroraffectsthemonolithictelescopes.

PROGRESS:(1) Developmodelthataccuratelysimulatestheeffect

MSFerrorhasonasystem’simagingperformance.(2) Verifythemodelusingempiricalmeasurementsfor

confirmation.(3) ApplytheMSFmodeltotheStage3telescopedesign

toperformsensitivityanalysisandtolerancing.

Modeling Mid-Spatial Frequency Roughness in Freeform Optics

05/06/2018

7

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/monolith-TeamMonolith_DDD_RevFinal.pdf

Participants:DavidHenryLippman (ProjectCoordinator),KevinKuyk (CustomerLiaison),Wooyoun Kim(DocumentHandler),MatthewPage(Scribe),Dr.JannickRolland(FacultyAdvisor)

Customer:Optimax Systems

References:Tamkin,JohnM.,andTomD.Milster."EffectsofStructuredMid-SpatialFrequencySurfaceErrorsonImagePerformance."AppliedOptics ,vol.49,no.33,2010,pp.6522.Tamkin,JohnM.,WilliamJ.Dallas,andTomD.Milster."TheoryofPoint-SpreadFunctionArtifactsduetoStructuredMid-SpatialFrequencySurfaceErrors."AppliedOptics ,vol.49,no.25,2010,pp.4814.Tamkin,JohnM.,TomD.Milster,andWilliamDallas."TheoryofModulationTransferFunctionArtifactsduetoMid-Spatial-FrequencyErrorsanditsApplicationtoOpticalTolerancing."AppliedOptics ,vol.49,no.25,2010,pp.4825.Rogers,JohnR.SlopeErrorTolerancesforOpticalSurfaces,vol.10316,SPIE,2007,doi:10.1117/12.725057.H.Aryan,C.J.Evans,andT.J.Suleski,"OntheUseofISO10110-8forSpecificationofOpticalSurfaceswithMid-SpatialFrequencyErrors,"inOpticalDesignandFabrication2017(Freeform,IODC,OFT) ,OSATechnicalDigest(online)(OpticalSocietyofAmerica,2017),paperOW4B.2.JasonA.Shultz,Hamidreza Aryan,JosephD.Owen,MatthewA.Davies,andThomasJ.Suleski.“Impactsofsub-aperturemanufacturingtechniquesontheperformanceoffreeformoptics.”

Comparisonofmodeledandmeasuredimagespotsthrough-focusfortheStage1design.Allspotsareonthesamerelativespatialscalebutnotthesamerelativeintensityscale.BothpossesstheexpectedMSFsignatures(above).

Page 8: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:• Inthefinalsystemset-up,awhiteLEDsourceisshinedtoa

mirrorthatistitled45° fromthez-axis.Thelightthenreflectstothesample,adielectricthinfilmonaSiO2wafer,thenbacktothemirror.Finally,thelightisreflectedtoanaperture,throughasinglelensandintoanRBGcamera.

• AcompleteMATLABalgorithmmatchesthereconstructedreflectanceforthe15filmsonthetrainingsampleand61thicknesssamplestoadatabaseoffilmthicknesses.

GOAL:Todevelopandproduceadual- anglecameraimagingsystemfordeterminingdielectricthinfilmthicknessintheRITMicroelectronicsCleanroomLab.

Reference:[1]Kruschwitz,JenniferDT,andRoyS.Berns."Dual-angle,spectralreconstructionimagingmethodforthedeterminationofdielectricthin-filmthickness."Opticsletters42.15(2017):3032-3035.

TASKS:• Finishedcameragammacalibration.• ConductedThicknessesmeasurementonsample

siliconwafersforinitialsystemtestingwithoutalgorithmanalysis.

• Designed,built,andtestedafinalizedsystem.• Developedanalgorithmandtestoncalibration

samples.

Instrument for Precise Measurement of Silicon Dioxide Films

05/05/2018

8

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/films-Team_Films_Final_DDD.pdf

Participants:YangDeng(ProjectCoordinator),ZhengTan(CustomerLiaison),DianaMagana(DocumentHandler,Scribe),JenniferKruschwitz&ClarkeEastman(FacultyAdvisors);Customer:J.Kruschwitz/RIT

Imagingboardcontainingtheaperture,lens,andcamera(left,up).Twoknobsnexttothemirror

(right,up).Set-upwithoutimaging

board(above).

Page 9: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

FinalDesignSet-up(left)andVisibilityPlotofalllabresults(right).

MAJORRESULTS:• Designedasystemtomeasurevisibilityevery10μm and

allowsformeasurementsofthecoherencelengthofvarioussources

• Futureplansincludeinvestigatingartifactsfromthebeamsplitter andaddressingthecompactnessofthedesign.

GOAL:Todesignandassembleaninterferometercapableofmeasuringandreportinginformationregardingthecoherencelengthofalaser.References:[1] Paschotta,Rudiger.“Coherence.”EncyclopediaofLaserPhysicsandTechnology-Coherence,Coherent,Light,SpatialandTemporalCoherence,Monochromaticity,20Feb.2017,www.rp-photonics.com/coherence.html.[2] “PropertiesofLasers.”Worldoflasers.com,6Apr.2015,worldoflasers.com/laserproperties.htm.[3] “7(D.g.).CoherentLight.”AndresRoboticsandScience,www.goodrichscience.com/7-dg-coherent-light.html.[4] Vamivakas,Nick.IntroductiontoWaveOptics.[5] “CoherenceLength.”Wikipedia,WikimediaFoundation,14Mar.2018,en.wikipedia.org/wiki/Coherence_length.[6] “Helium-NeonLasers.”Sam'sLaserFAQ-Helium-NeonLasers,donklipstein.com/laserhen.htm#henmtmhl.[7]CustomerPowerPointPresentation[8]VladimyrosDevrelis,MartinO'Connor,andJesperMunch,"Coherencelengthofsinglelaser

TASKS:• Developedandupdatedaninterferometerprototype.• UsedFREDtomodeltheimpactofdiffractiononthesystem.• Developedasoftwareanalysismethodtocreateaplotofthe

visibilityasafunctionofopticalpathlengthdifferencethroughcalculatingtheimagealongeachlineofthegratingandthoughcalculatingthegratingline.

Instrument for Measurement of Coherence Length of Sources

05/06/2018

9

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/coherence-Team_Coherence_Final_DDD.pdf

Participants:MaxwellWolfson(ProjectCoordinator),LeiDing(CustomerLiaison),PellegrinoConte(DocumentHandler,Scribe),ThomasBrown(FacultyAdvisor);Customer:ASML

Page 10: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:• Optimizedtheinputpowerat500mWto

increasethesignal.• Recommendedthattoexposethesample

fornomorethan5-6minutestoavoiddamage.

GOAL:TooptimizetheSHGscanningsystemtobetterpredictmetastasisinbreastcancertissue.Themetrictopredictmetastasisistheratiooftheforwardtobackwardratio(F/B)ofscatteredlight.

TEST:• Analyzedthelaserleakageanddarknoisecorrection.• Calculatedthesampledamageathighpowersandover

time.• InvestigatedanHighDynamicRange(HDR)toolboxfor

MATLABtoovercomethedynamicrangelimitations.

Metastatic Cancer Detection with Second Harmonic Imaging

05/06/2018

10

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/cancer-TeamCancerFinalDDD.pdf

Participants:JordanRabinowitz(ProjectCoordinator),Yuanchao Wang(CustomerLiaison),AvaHurlock(DocumentHandler),JamesEmery(Scribe),WayneKnox(FacultyAdvisor)Customer:Harmonigenic /Dr.RobertHill

ReferencesFrancescoBanterle,AlessandroArtusi,KurtDebattista,andAlanChalmers.AdvancedHighDynamicRangeImaging:TheoryandPractice.AKPeters(CRCPress),Natick,MA,USA,2011.K.Burke,M.Smid,R.P.Dawes,M.A.Timmermans,P.Salzman,C.H.M.canDeurzen,DavidG.Beer,J.A.Foekens,E.Brown.UsingSecondHarmonicGenerationtoPredictPatientOutcomeinSolidTumors.2015,BMCCancer15:929.JuanM.Bueno,FranciscoJ.Avila,PabloArtal,ComparisonofSecondHarmonicMicroscopyimagesofCollaged-basedOcularTissueswith800and1045nm.2017,BiomedicalOpticsVol.8No.11.Pantazis,Periklis etal.“SecondHarmonicGenerating(SHG)Nanoprobes forinVivoImaging.”ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica107.33(2010):14535–14540.PMC.Web.4Feb.2018.Theodossiou T.,G.S.Rapti,V.Hovhannisyan,E.Georgiou,K.Politopoulos,D.Yova,ThermallyInducedIrreversibleConformationalChangesinCollagenProbedbyOpticalSecondHarmonicGenerationandLaser-inducedFluorescence.2002,LasersMedSci 17:34-41.Williams,RebeccaM.,WarrenR.Zipfel,WattW.Webb,2005,InterpretingSecond-HarmonicGenerationImagesofCollagenIFibrils.BiophysicalJournalVol.881377-1386.Xi.Chen,OledNadiarynkh,SergeyPlotnikov,PaulJCampagnola,Secondharmonicgenerationmicroscopyforquantitativeanalysisofcollagenfibrillar structure.2012,NatureAmerica,10.1038/nprot.2012.009.

Fromthegraph,500mWallowsforoptimizedsignalforanextendedperiodoftime(above).

Page 11: 05/02/2018 Imaging Characterization of Ultra-Wide Field AR ...Williams, D. R. (2003). Subjective image quality metrics from the wave aberration. Paper presented at the 4th International

MAJORRESULTS:• Fresnellensshowntohavea

considerablylessattenuationthantheinitialsphericalbiconcavelens.

• However,thelowerattenuationvalueintroducedanartifact:abroadsecondarysignaloccurring~200μsaftertheinitialpeak.

GOALS:(1)Todesignthelenssystemforanimagingprobeusedforinvivo detectionofcancerwithinthethyroid.

(2)To reducethesignalattenuationthatwasaconsequenceofusingabiconcaveplasticlenstofocustheultrasoundsignalbyexploringaFresnellensinthisconfiguration.

TESTS:• DevelopedaninitialdesignbasedonaFresnellens,was

testedinCodeV,andtestedinalabsetting.• LabTest:Bytheemissionofanultrasonicwavefocused

bytheFresnellensontothetransducerarray,whichcapturedasignalpulsethroughtime-gating.

• Updatedthedesignforanewzonesagtoaccountforacleanersignal.

• Testedthesurfacequalitytodemonstratethepotentialinfluenceonthelensperformance.

:

Acoustic Fresnel Lens Design05/05/2018

11

Readthefullreport:http://www2.optics.rochester.edu/workgroups/knox/myweb/opt310-311-files/2017/311/acoustic-TeamAcousticFinalDDD.pdf

Participants:RyanSauer(ProjectCoordinator),NancyAguilera(CustomerLiaison),Yichen Gu(DocumentHandler),DanielGraney(Scribe),WayneKnox(FacultyAdvisor);Customer:URMC/Navalgund Rao

References“MEASUREMENTREPORT:3MHzMatrixArrayTransducer”Imasonic.RIT.3July.2017.Francis,Kalloor Josephetal.“CharacterizationofLensBasedPhotoacousticImagingSystem.”Photoacoustics 8(2017):37–47.PMC .Web.18Nov.2017.“Accura 25(SLA)DataSheet.”3DSystems .2017.“Objet30ProSpecificationSheet.”Stratasys .EdenPrairie,MN.2015.Hadimioglu,B,etal.“High-efficiencyFresnelacousticlenses.”XeroxPaloAltoResearchCenter. 1993.Willis,Karl,etal."Printedoptics:3Dprintingofembeddedopticalelementsforinteractivedevices."Proceedingsofthe25thannualACMsymposiumonUserinterfacesoftwareandtechnology .ACM,2012.“MakerBot Replicator5thGenQuickSpecs”RedStack.“PolyJet MaterialsDataSheet.”Stratasys .EdenPrairie,MN.2017.“AcousticTablesofReference.”Ondacorp .2016.

InitialFresnelSignal(left)andUpdatedFresnelSignal(right)