1 animal nutrition. 2 figure 41.1 homeostatic regulation of cellular fuel
TRANSCRIPT
3
Figure 41.2 A ravenous rodent
Leptin receptors are found in high concentrations in the hypothalamus, region of the brain that’s known to be involved in regulating appetite and metabolism.
8
Figure 41.10 Intracellular digestion in Paramecium
Paramecium Still Images
12
Figure 41.14 From mouth to stomach: the swallowing reflex and esophageal peristalsis (Layer 1)
Components of Saliva
Mucin
Buffers
Antibacterial agents
Salivary amylase
When not swallowing, the glottis is open.
13
Figure 41.14 From mouth to stomach: the swallowing reflex and esophageal peristalsis (Layer 2)
When swallowing: the glottis moves down closing off the trachea and bolus moves down esophagus.
15
Figure 41.15 Secretion of gastric juice
Gastric Juice
a) Pepsin and pepsin- ogen (zymogen)
b) HCl
Positive feedback: some activation of pepsinogen increases production of pepsin.
Heliocobacter pylori
16
STOMACH
Stimulation
Gastrin from stomach into circulatory system
stimulates release of
Pepsin
HCl Pepsinogen
19
CHO Digestion
Sucrase, lactase
Protein Digestion
Trypsin(trypsinogen) and chymotrypsin (chymotrypsinogen)
look for specific bonds in polypeptides and make smaller fragments.
Procarboxypeptidase (zymogen) for carboxypeptidase which will split one amino acid off of a polypeptide at a time (at the COOH end)
Aminopeptidase as at the amino end of the polypeptide chain.
All this is triggered by enteropeptidase.
21
What Regulates the Secretion of These Digestive Enzymes?
1. Secretin
2. Cholecystokinin( CCK )
3. Enterogastrone
22
Small Intestine
Receives low amino acids and fatty acids fats
pH chyme
Enterogastrone
Secretin Cholecystokinin (CCK) (slows passage of food into SI)
(from intestinal wall) Pancreas Gall Bladder Bile
Procarboxypeptidase carboxypeptidase
(Pancreas)
HCO3- +
Chymotrypsinogen chymotrypsin
+
Trypsinogen trypsin
24
Evolutionary Adaptations of Vertebrate Digestive System
1. Dentition and Diet
a) Mammalian vertebrates
b) Nonmammalian vertebrates
2. Length of vertebrate digestive system
28
Symbiotic Relationships in Herbivores
Vertebrates and termites have microorganisms (protists and bacteria). . .
29
What Is Fat?
Fat Or Adipose As A Tissue
• Fat is used for energy storage and insulation
• It is involved in metabolism. It really doesn’t just sit there.
• Fat cells express certain genes and secrete hormones as well as other signaling molecules.
30
What Is Fat?
Fat As a Cell
• Fat cells are called adipocytes
• Adipocytes are specialized for storing fat.
• Inside the adipocyte are the fat droplets
31
What Is Fat?
Fat As a Molecule
• It’s a lipid
• Triglycerides are a form of lipid and they consist of one glycerol molecule and 3 fatty acids (remember?)
• Triglycerides store 3 times more energy than sugars per gram.
• Saturated Fats vs. unsaturated fats
32
How the Body Processes Fat
The body’s primary energy source is glucose
Any excess glucose is stored in your muscles and liver as glycogen.
Any excess beyond this is converted to fat (triglycerides) for storage.
Between meals when glucose levels drop, either
1) glycogen is broken down to glucose (glycogenolysis) or
2) the body makes glucose from other precursors (gluconeogenesis)
3) triglycerides can also be catabolized for energy (glycerol is used for gluconeogenesis and the fatty acids are broken into 2 carbon units for the Krebs cycle
33
How the Body Processes Fat
Cholesterol
• Cholesterol is a form of lipid
• Component of cell membranes
• Used to make steroid molecules and also bile salts
• Transported with fat in what are called “lipoproteins.”
• Low Density Lipoproteins (LDLs) vs. High Density Lipoproteins (HDLs)
34
Transportation of Fat
Lipoprotein Structure
• Phospholipids and cholesterol form a sphere on the outside (where it would contact water). Therefore the hydrophilic regions are pointing outward.
• Apolipoproteins, another protein, are also on the surface and these regulate the function of the lipoproteins.
• Inside this sphere are triglycerides and cholesterol esters.
36
Transportation of Fat
Lipoprotein Size and Origin
Small Intestine Transports fat and cholesterol absorbed from digested food from the gut to the rest of body.
Liver Supply the body with triglyc- erides synthesized in the liver.
Converted VLDL Supply the body with cholesterol
Multiple Sources Collect excess cholesterol and transport it to the liver.
chylomicron
VLDL
LDL
HDL
37
Transportation of Fat
Lipoprotein Conversion
• The lipoproteins can be converted from:
chylomicron
Chylomicron remnants
LDL
VLDL
Fatty Acid Transport
• Fats are leased from the fat cells in the form of fatty acids.
• These become bound to a protein, albumin, that can transport them throughout the body.
• Each albumin molecule can carry 7 fatty acids.
38
What Goes On Inside Cells?
There are regulatory molecules that control what happens to fat
• PPARγ: fat sensor that belongs to a class of molecules called nuclear receptors (found in the nucleus).
• PPARγ molecules bind to fatty acids, become activated and cause cells to store fat.
• PPARδ: fat sensor that belongs to a class of molecules called nuclear receptors (found in the nucleus).
• PPARδ will bind to fatty acids, become activated and cause cells to metabolize of “burn” fat.
39
Endocrine Regulation?
Your hypothalamus in your brain is a center for many activities, one of which is appetite and hunger.
• Appetite is stimulated by a hormone called ghrelin.
• Appetite is suppressed by leptin, insulin, cholecystokinin and 2 other peptides (peptide YY and glucagon-like peptide-I)
Normally, the more fat you have in a cell, the more you have a signal that tells the brain it can reduce food intake. In obese people, the brain does not sense these higher levels of leptin; they are less responsive to the signal that tells them to reduce food intake.
40
How the Body Processes Fat: Part II
From Mouth To Stomach
• Triglycerides are not digested in mouth but the complex carbohydrates do get broken down into complex sugars.
• So in the stomach you have triglycerides and complex sugars and off they go to the small intestine.
41
In Small Intestine
• Bile acids made in liver and stored in the gall bladder are delivered to the duodenum. Bile salts break up the triglycerides into small droplets.
• Pancreas secretes lipase which removes the fatty acids from the triglycerides.
• The triglycerides are digested into one fatty acid attached to glycerol, a monoglyceride, and this can be absorbed into the blood stream.
42
At the Liver
• The liver can take stored or absorbed glucose and convert it to:
• glycerol (which can then become a triglyceride)
• glycogen
• fatty acids (which can then become a triglyceride)
43
• These triglycerides can leave the liver and go to the blood stream and:
• combine with proteins to become VDLP and go to a muscle cell
• or they can go to a fat cell and become fatty acids and be stored
At The Muscle Cell
• the triglycerides can become fatty acids and be used for energy