1) food processing paper-i (general food processing) food processing paper-i (general food...
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1) Food Processing
Paper-I
(General Food Processing)
1. Constituent of foods – Sources of food, properties and significance of carbohydrates,
Proteins, fats, vitamins & minerals.
2. Nutritive Aspects of food constituents – Energy.
3. Food deterioration and control – Causes of food spoilage and their control measures.
4. Methods of food preservation – Thermal processing – pastcurizion, sterilization.
5. Cold preservation of food – Freezing, chilling.
6. Drying methods of food – sun drying, dehydration, concentration.
7. Oilseeds, legumes, pulses.
8. Food grains, cereals.
Paper – II
(Milk, Meat, Poultry & Egg Processing)
1. Milk and properties of milk, constituents, importance, composition of milk, Food &
nutritive value of milk.
2. Milk products – random milk products khoa, rabori, kulfi, pancer, shrikhond, ghee, lassi,
Western dairy products – cream, butter, ice- cream, cheese, condensed milk.
3. Meat, poultry and egg processing.
4. Fish & Fish products and their processing.
5. Food preservatives & their uses.
Class – I preservatives – sugar, salt spices etc.
Class – II preservatives – K.M.S., SO2, acetic acid (Vinegar) etc.
6. Packaging Techniques in milk, meat poultry & Fish.
7. Commercial canning & steps of canning.
8. Containers, metallic plastic containers, their merits & demerits.
Paper – III
(Fruits & Vegetable Processing)
1. Importance of fruits & vegetable in our daily diet – Source of vitamins. Minerals, role of
fruits & vegetables as protective food.
2. Deterioration of fruits & vegetables their control measures, i.e. physical method,
chemical methods.
3. Post harvest losses in fruits & vegetables.
4. Packaging techniques of fruits and vegetables – wax coating, modified atmospheric
packaging, and controlled atmospheric packaging.
5. Containers for fruits & vegetables packaging, their merits & demerits, glass containers,
metallic containers.
6. Jam, jelly ingredients and their role in jam preparation, fruits for jam & jelly, difference
between jam & jelly.
7. Beverages – grape wine fruit beer preparation methods, preparation of pickles coffee &
tea.
8. Tomato products –Tomato juice, ketchup, Tomato sauce, Tomato saup, etc.
Paper – IV
(Practical)
1. Extraction of Oils and Fats
2. Preparation of Milk and other products of Soybean.
3. Dehusking of Rice, Cereals & Pulses.
4. Determination of Iodine Value.
5. Determination of saponification value.
6. Preparation of Cake.
7. Preparation of fruit Cake.
8. Preparation of nonkatai.
9. Preparation Biscuits.
10. Preparation of Guva Jelly – Guva Jelly, Apple Jam.
11. Preparation of Papaya a Cherry (Candy)
12. Preparation of Fruit Squash – Apple squash, Mongo Squash, Grapes squash.
13. Preparation of Tomato Ketchup.
14. Preparation of Vegetable soup.
15. Preparation of Mixed fruit jam.
16. Preparation of grape resin.
17. Preparation of Mango Pickle.
18. Preparation of Lemon pickle.
19. Visit to Food Processing Industries:
(Udgir – Vikram Agro Processing Udgir, MIDC, Udgir, Latur – Pray foods MIDC, Latur,
Dalmill / Oil mill – Tinna/ Kirti, etc.)
20. Visit to Training Institutes:
(CFTRI – Mysore, College of food Technology Marathwada Agril. University Parbhani,
College of Food Technology (Queens) Aurangabad, etc.)
21. Visit Food Technology Department of Agricultural University.
Annexure – II
List of Books:-
1. Food Science – Norman Potter
2. Outline of Dairy Technology – Sukumar De – Oxford University Press
3. Preservation of fruits & vegetables – Girdharilal & Siddappa.
4. Advanced Dairy Technology – Trevor Britz Robinson.
5. Food Microbiology – Frazer
6. Food Biochemistry – Dietrich Knorr
7. Principles of Fruit Preservation – Morris. T.N.
8. Microbiology of Food – Srivastava.
9. Handbook of Food & Nutrition – Blank F.C.
10. Chemistry of food & Nutrition (8th
ed) – Sherman H.C.
11. Drying & Dehydration of Foods – hoesecke H.W.V.
12. Food Microbiology – Bohra, A.
13. Encyclopedia of commercial food Products – Blumenthal S.
14. Food Technology Processing & Laboratory control – Aylwerd F.
15. Outline of Food Technology – Harry Loeseeke.
16. Principles of Fruit Preservation – Jam Making, Canning and Drying – Morris T.N.
17. Techniques of Food Analysis – Winton A.L.
18. The Chemical Composition of Foods – Me Cance R.A.
19. Trace Elements in Food – Monior – Williamas G.W.
20. A text book of dairy chemistry – Ling Edgos R.
21. Milk & Milk Products – Winton, A.L.
22. Dairy Microbiology – Parihar P.
23. Cheese & Butter – Cheke V.
24. Technology of Dairy Plant Operations - Sangawan K.P.S.
25. Fish & Fish Products – Winton A.L.
26. Fish Processing & Presersation – Cutting, C.L.
27. Fermentation Technology – Singh, Tanuja
28. Post Harvest Food Grain Storage – Barman, H.
29. Handbook of Fruit & Vegetable Products – Ashraf S.M.
30. Post harvest Technology & Farm Mechanization – Ponda, S.C.
31. Post Harvest Technology – Pentastico
32. Elements of Food – M.S. Swaminathan.
2)Computer Hardware And Netwroking
Paper – 1
Fundamentals Of Computers
1. Basics of computers:-
Introduction, functional block diagram of PC with its internal working Classification of
computers (Micro, mini frame, super computer, pc, server, workstations),
What is Microprocessor, Ideal microcomputer, An Actual microcomputer, Minimum
microcomputer configuration.
2. Data Representation With in Computer:-
Introduction to Number system: Binary, Octal, Decimal and Hexadecimal.
Conversation from one number system to another number system, BIT, BYTE, WORD
ASCII, EBCDIC, BCD Code, GRAY code, Logic gates – Universal gates, NAND, NOR.
3. Input / Output Devices:
Basic I/O devices, keyboard, mouse, scanning devices – (BAR CODE, OMR, MICR),
Light pen, Mouse, Touch Screen, Digitizer,
Printers: Impact and Non-impact printers. Printers – (Dot matrix, chain, drum, inkjet,
laser, Plotters), Monitors – CRT, LCD, CD-WRITTER,ZIP DRIVE, DVD
4. Memory:-
Flip – Flops (Flip – Flops as a register, buffer, latch), Cache memory, Primary and
secondary memory (RAM, ROM, PROM, EPROM, EEPROM), Associative memories,
virtual memories, Storage devices – Tape, FDD, HDD, CDROM, Pen Drive.
Optical disks, Flash memories, HDD, Memory system for microcomputer.
5. Operating System:-
Definition of OS, Types of OS.- Multi user, Multi Processing, Functions of OS.
Introduction to Windows XP OS.
Reference Books:-
1) FUNDAMENTALS OF COMPUTERS BY V. RAJARAMAN.
2) COMPUTERS AND COMMONSENSE BY R. HUNT AND SHELLY.
3) FUNDAMENTALS OF COMPUTER SYSTEMS. LOW PRICE EDITION.
4) MICROPROCESSOR B. RAM.
Paper – II
Computer Networks
1. Data Communication Concepts:-
A communication mode, Data Communication, Data Communication networking
(concepts):- LAN, WAN, MAN, ATM, ISDN, Broadband, Types of signals, Data
encoding techniques, Bandwidth concepts Channel capacity, Synchronous and
asynchronous transmission.
2. Transmission Media and Network Topology:-
Magnetic media, Twisted Pair, Coaxial cable, Fiber optics Structure of Bus, Ring, Star,
tree and other topologies and advantages and limitations.
3. Connection, Interfacing and Devices:-
Connection oriented and connections services. Serial and Parallel connections:- half and
full duplex operations.
Connectors:- D-Connector and RJ-45modular connections.
Modern connection and signaling, Repeaters, Bridges, Routers, Gateways Hub and
Switch, Frame relay.
4. Multiplexing and Switching:-
Concept of modulation and their application, Time Division Multiplexing, Frequency
Division Multiplexing, Circuit Switching, Packet switching Message switching.
5. Network Standards:-
Introduction, Protocol Hierarchies, OSI Model:- Physical, data link, network, transport,
session, presentation and application layers, Advantages of layers.
6. Network Protocols:-
TCP/IP Protocol: approach, architecture, operation and application, Use of protocols
like:- SMTP, PPP, FTP, HTTP. Concept of DNS.
7. Communication Satellites:-
-Geosynchronious satellites
-Low-orbit satellites.
Books Recommended:
1) GERD E. KEISER, “LOCAL AREA NETWORKS,” TATA MCGRAW HILL
EDITION, NEW DELHI.
2) PETER HODSON, “LOCAL AREA NETWORKS,” (THIRD EDITION), BPB
PUBLICATION, NEW DELHI.
3) WILLIAM STALLINGS, “DATA AND COMPUTER COMMUNICATIONS,” (FIFTH
EDITION), PRENTICE – HALL OF INDIA PVT. LTD, NEW DELHI.
4) ANDREW S. TANENBAUM, „COMPUTER NETWORKS,” (THIRD EDITION),
PRENTICE – HALL OF INDIA PVT. LTD, NEW DELHI.
Paper III
Essentials of Computer Hardware and Networking
1. Identification of Computer Parts:
SMPS, Mother Boards, CPU, RAM Monitors, Drivers, Hard Disks, CD Rom/Writers,
Keyboards, Mouse, Ports Special Devices, ADD- ON Cards.
2. Assembling of Computers:-
Building your own PC with all parts, Installing Mother Boards and other peripherals on
it. CMOS Setup, detecting GHDD and others, Formatting of HDD.
3. Installation of O.S. and Application Softwares :-
O.S. loading, Windows XP, Vista, Windows 2000, Installation of other peripherals like
printers, Modem, Installation of Application Software like Page Maker, Corel Draw, MS-
Office and others.
4. Networking Essentials:
Overview of Networking, Overview of Network Components, Network Hardware,
Transmission Media, LAN Topologies, Installing Cabling, Network Software, Switches
and Bridges, TCP/IP and Services, IP Addresses.
5. Making small networks.
Installing and configuring a network Interface Card, MAC Addressing, Implementing a
TCP/IP Network, Installing and configuring Novell Net Ware 6, Installing and
Configuring Novell Client, Understand Network Printing Concepts, Seting up a local
printer, Sharing Printer, Describing Windows Network Management Tools – Windows
XP Professional Workstation Tools.
Books Recommended:
1)MIKE MEYER‟S COMPUTER SKILLS “INTRODUCTION TO NETWORKING”
RICHARD A. MCMAHON, SR. UNIVERSITY OF HOUSTON TATA MCGRAW-HILL
EDITION.
2)GUIDE TO NETWORKING ESSENTIALS SECOND EDITION DAVID JOHNSON.
3) NETWORKING IN EASY STEMPS – PETER INGRAM.
4) COMPUTER HARDWARE COURSE – 9TH
EDITION.
5) COMPUTER NETWORKING COURSE - 5TH
EDITION.
Paper IV
LAB- A
1. Study of Logic gates – Universal gates,
2. Study of NAND, NOR gates
3. Study of Flip – Flops. – S-R Flip – Flop
4. Study of Flip – Flops. – JK Flip-Flop
5. Study of Flip - Flops. – Master Slave – Flip-Flop
6. Identification of Computer Parts: SMPS, Mother Board,
7. Identification of Computer Parts: CPU, RAM,
8. Identification of Computer Parts: Monitors, Hard Disks
9. Identification of Computer Parts: CD ROM, Writers,
10. Identification of Computer Parts: Keyboards, Mouse
LAB- B
1. Assembling of computers :-
a) Installing Mother Board b) Installing Microprocessor c)Installing SMPS d) Installing
RAM e)Installing CD ROM/Writer, HDD.
2. Connecting Power supply to PC and other Peripherals.
3. CMOS Setup.
4. Installing various OS.
5. Making Partition.
6. Installing Various Application Software‟s (Page Maker, Corel Draw, MS-Office)
7. Installing of NIC cards.
8. Cabling – Preparing cable for small networks- D and RJ-45 Connector CAT 5 Wire
9. Crimping with RJ-45 Twisted pair cable, Straight crimping.
10. Making a small network with cross cabling
11. Making a small network with HUB.
12. Making a small network with SWITCH.
3)Syllabus For Certificate Course in Embeded System & Design
Paper – I No. of Periods -100
Basic Electronics & ‘C’ Programming
1.Basic Electronics:- 30 Marks
Introduction to electronics & nature of electricity
Transistors, Diodes, Registers, Capacitors & Inductors
Amplifiers, Oscillators, Multivibrator
2.Digital Electronics:- 30 Marks
Transition from analog computing to digital computing
Logic gates, Multiplexers, Demultiplexers, Encoders, Decoders, Flip – Flop, ADS &
DAC
Memory devices – RAM, EPROM, FLASH
3.Basics of C Programming:- 40 Marks
Control Structures, Functions and Pointers.
Pre- Processor
Arrays, Keywords, Data Structures, Functions and Libraries
Bitwise operators and File handling
Interaction with hardware
Advanced pointers and structures
Function pointers
Data Structure including linked list binary trees, stacks queues
Processor architecture specific issues of C Programming
Writing efficient space and time constrained programs in C.
Paper –II No. of Periods -100
Introduction to 8 bit Microprocessor, Microcontroller & Debugging Technique
1.Introduction to 8 – Bit Microprocessors and Microcontroller 40 Marks
Microprocessor architecture, Interrupts basics System buses, flags as on ex.8085
AVR RISC Microcontroller Architecture
AVR Instruction set and assembly Language Program
Hardware Resources – Memories, Timers, Counters, VART, SPI, Interrupts
Shared data problem, interrupt latency
2.Device Driver & Interfacing Applications 30 Marks
Concept of device driver
Interfacing of seven segment display & LCD display
Interfacing diagram & pin out of LCD
Interfacing of keyboard ADC & DAC – interfacing Diagram & Programming
Interfacing of stepper motor interfacing diagram & programming
3.Debugging Techniques 30 Marks
Testing on your host machine
Instruction set simulator
The assert macro
Using Lab tools
Paper –III No. of Periods -100
Embedged System & Operating System
1.Embedged System 25 Marks
Introduction, different hardware units, Advantages like reliability, Efficiency and cost,
applications.
Software & hardware development tools, IDE, compiler, Debugger Simulator, Emulator,
In circuit Emulator (ICE), Target Board, Device Programmer.
2.Introduction to Operating Systems 25 Marks
Computer architecture and operating system overview
Processes, Threads
Synchronization and deadlock
Memory Management and virtual memory
CPU scheduling and algorithms
Inter process communication
File and I/O Management
Networking and distributed systems.
3.Embeded and Real Time Operating systems 25 Marks
RTOS fundamentals and hardware architecture
RTOS Conventions and objectives
Process and thread Magt in RTOS
Inter thread communication
Scheduling and resource Magt
Kernel services
Interrupts and exceptions
Memory models
Power Magt
Boot process
Real time
Ensuring performance
4.Case Study-Embeded Linux, Nut/OS Writing Device Drivers 25 Marks
Identifying device characteristics
Describing device usage
Designing device driver
Types of device drivers (Char, block, network)
Mapping device and Kernel memory
Device context Magt
Registering device interrupt handlers
Compiling, Loading, Packaging, Testing Drivers
Reference Books:
Sr.
No.
Author Title Publisher
1. Raj Kamal Embeded System Tata McGraw Hill
2. Muhammad The 8085 Microcontroller &
Embeded Systems
PHI
3. Ajay V. Deshmukh Microcontroller (throry &
Application)
Tata McGraw Hill
4. Kenneth J. Ayala The 8051 Microcontroller PRI
5. Frank Vahid Toney Givargis Embeded system design: A
Unified Hardware/Software
Introduction
John Wiley
6. David E. Simon An Embeded Software Primer Pearson Education
Paper- IV
Practicals For Certificate Course in Embeded System & Design
No. of Periods -150
Practical -100 Marks
Field Work/Project -50 Marks
1. Verification of Logic gates.
2. Study of Flip – Flop.
3. Study of Multiplexer & Demultiplexer.
4. Study of Encoder & Decoder.
5. Analog to digital conversion.
6. Digital to analog conversion.
7. Development & execution of the program for sending data on port lines.
8. Development & execution of the program for input & output operation.
9. Development & execution of the program for arithmetic operation & time delay.
10. Development & execution of the program for interface LED to particular port.
11. Development & execution of the program to generate a square wave on port.
12. Development & execution of the program for logical operators and data conversion.
13. Development & execution of the program to display “MSBTE” message on LCD (16*2)
14. To writer 8051 C program to send “WELCOME” on serial port Continuously.
15. Interface stepper motor to microcontroller 8051 & development and execution of the
program to display digital equivalent of analog input.
16. Interface DAC to microcontroller 8051 development and execution of the program to
generate specified voltage.
17. Program for call by value & call by reference.
18. Program for memory allocation function using pointer.
19. Program for displaying values and their address from array by using pointer and address
operator.
20. Program for pointer operation.
21. Binary equivalent of decimal numbers.
22. Program for right shift and left shift operator.
23. Program to determine ASCII equivalent of Hitkey.
24. Program for set a position of cursor on specified location.
25. Program for finding the memory size.
26. Active video page.
27. Program to display Character in full screen.
4) UGC FUNDED ONE YEAR
P.G. DIPLOMA IN BIOINFORMATICS
ELIGIBILITY: Bachelor Degree in Life Sciences, Agriculture, Pharmacy, Medical Sciences,
Biotechnology from a recognized University
(For students admitted from 2010-2011 onwards)
Semester I
Paper No. Title of Paper I.A. U.E. Total Workload
DB – 01 Basics of Bioinformatics 25 75 100 04 Periods/ week
DB – 02 Statistics for Bioinformatics 25 75 100 04 Periods/ week
DB – 03 Basic Structural Biology 25 75 100 04 Periods/ week
DB – 04 Object Oriented Programming and
Web Publishing
25 75 100 04 Periods/ week
DB PR – 01 Practical – I : C++ Programming
and Web Publishing Lab
25 75 100 08 Periods/ week
DB PR – 02 Mini Project 10 40 50 08Periods/ week
Total 135 415 550 32 Periods/Week
Semester II
Paper No. Title of Paper I.A. U.E. Total Workload
DB – 05 Data Base Management Systems 25 75 100 04 Periods/ week
DB – 06 Bio - Physics 25 75 100 04 Periods/ week
DB – 07 Genomics and Proteomics 25 75 100 04 Periods/ week
DB – 08 Computational Biology 25 75 100 04 Periods/ week
DB - 09 Elective (anyone of the following)
a. Commercial Applications
of Bio-informatics
b. Molecular Modelling and
Drug Design
c. Biodiversity
Bioinformatics
25 75 100 04 Periods/ week
DB PR – 03 Practical – Bioinformatics Lab 25 75 100 08 Periods/ week
DB PR – 04 Project 10 40 50 08Periods/ week
Total 160 490 650 36 Periods/Week
Note:-1
Semester – I – Marks :550
Semester – II – Marks :650
Total of two Semesters = 1200
Note :-2
Internal Assessment will include attendance, assignments, unit tests and seminars.
Note :-3
I.A. : Internal Assessment
U.E. : University Assessment
Paper – I (DB -01) - Basics of Bioinformatics
Unit I
Bioinformatics – an overview, Definition and History, Information Networks – Intrnet in
Bioinformatics, EMBnet – Commercial Databases and Software, Intranet and Internet Packages,
Bioinformatics Glossary.
Unit II
Languages – Basics of Programming
Perl – Basics, String handling, subroutines.
HTML – Basics, Tags, Text Handling, Image handling, Links, Frames and Tables.
XML – Basics, data binding and record sets.
Unit III
Protein Information Resources – Biological Databases, Primary Sequence
Databases, Composite Protein Sequence Databases, - Secondary Databases –
Prosite, Prints, Blocks Profiles and Identity.
Unit IV
Genome Information Resources – DNA sequence Databases – EMBL DDBJ, Genbank GSDB (
Genome, Sequence Database), UniGene.
Unit V
Evolution of Bioinformatics – Scope – Potentials of Bioinformatics Human Genome Project –
Bioinformatics in India – Future of Bioinformatics.
Reference Books:-
1. T.K. Attwood and D.J. Parry –Smith, Introduction to Bioinformatics, Pearson Education
Ltd., Net Delhi (2004).
2. Arthur M. Lesk, Introduction to Bioinformatics, Oxford University Press, New Delhi
(2003).
3. D. Higgins and W. Taylor (Eds), Bioinformatics – Sequence, Structure and databanks,
Oxford University Press, New Delhi (2000).
4. A. Baxevanis and B.F. Ouellette. Bioinformatics : A Practical Guide to the Analysis of
Genes and Proteins, Wiley – Interscience, Hoboken, NJ (1998).
5. S.R. Swindell, R.R. Miller and G.S.A. Myers (Eds.), Internet for the Molecular Biologist,
Horizon Scientific Press, Wymondham, UK, (1996).
6. Andrea Cabibbo, Richard Grant and Manuela Helmer –Citterich (Eds.), the Internet for
Cell and Molecular Biologists (2nd
Edn.), Horizon Scientific Press, Norwich, UK(2004).
Paper II (DB-02) – Statistics for Bioinformatics
Unit I
Measures of central Tendency – Arithmetic Mean – Median – Mode – Quartiles – Range –
Quartile deviation – Mean deviation – Standard Deviation.
Unit II
Probability – Addition Theorem – Multiplication Theorem – Baye‟s Theorem and related
problems.
Unit III
Theoretical Distributions – Binomial, Poisson and Normal – Fitting of the Distributions and its
properties – Z-score, P-value and e-value.
Unit IV
Theory of attributes – Introduction- Dichotomy –Consistency of Data- Independence of
Attributes – Association of Attributes – Rules coefficient of Association.
Unit V
Sampling Distributors – Large and small sample tests – Student‟s t0 test, X2 test, F-test – and
Normal test and their applications.
Text Book:
1. S.C. Gupta and V.K. Kapoor, Fundamentals of Mathematical Statistics, 11th
Edition,m
Sultan Chand & Sons, New Delhi, 2002.
Reference Books:
1. S.P.Gupta, Statistical Methods, Sultan Chand & Sons, 1996.
2. L. Forthofer, Introduction to Biostatistics, Academic Press, 1995.
3. Robert R. Sokal and F.J. Rohlf, Introduction to Biostatistics ( Biology-Statistics Series),
W.H. Freeman & Company, New York, 1987.
Paper III (DB-03) – Basic Structural Biology
Unit I
Cell Structure and Ultra cell structure of Pro and Eukaryotic cells – Cell wall – cell membrane –
Biomembranes – Organelles.- Diffusion – Active and Passive Transport – Osmoregulation.
Unit II
Carbohydrates – Classification Types – Structure – Function.
Lipids – Classification Types- Structure – Function.
Unit III
Classification of amino Acids. Classification and three- Dimensional structure of proteins.
Overview of protein structure – Primary, Secondary, Tertiary and Quaternary structures – J helix,
K Pleated sheet, Ramachandran plot and bonds stabilizing protein structure.
Unit IV
Principles of Structural Organization and Conformational Analysis.
Prediction of Protein structure – Fold Recognition (threading), Comparative Modeling
(homology), The Chou and Fasman Scheme. Basic Principles of X-ray Diffraction Studies,
NMR, Mass Spectroscopy in Identifying Protein Conformation.
Unit V
Introduction and Physiochemical Properties of Nucleic Acids – DNA and RNA. Watson and
Crick Model of DNA and the different forms of DNA. RNA structure – Principles and
Prediction. Gene Structure.
Reference Books:
1. Principles of Physical Biochemistry – Van Holde, Prentice Hall.
2. Basic one & two dimensional NMR spectroscopy, Horst Friebolin Witey- VCH-1990.
3. Lechninger Principles of Biochemistry – David L. Nelson, Michael M.cox. 3rd
Edition
Macmillan worth Publishers.
4. Principles of Protein structure, G.E. Shuttz and R.H. Schirmer, Springer – verlag, New
York.
Paper IV (DB-04) – Object Oriented Programming in C++, JAVA and Web Publishing
Unit I
Introduction to Computing : Introduction to Programming, Computer Organization, Evolution
of operating systems, Personal, distributed client/server computing, Machine languages,
Assembly languages and high level languages, Structured programming, Object Technology
Backbone of OOP: Abstract Data Type (ADT), Encapsulation, Object, Message, Method, Class,
Inheritance, Late Binding Polymorphism, Virtual Functions, Abstract Classes, Interface, Generic
Classes and Interfaces, Constructors, Constructors and Destructors, Overloading and overriding,
copy constructor.
Unit II
Exception Handling, I/O and JDBC: Exception Handling: Fundamentals exception types,
uncaught exceptions, throuw, throw final, built in exception, creating your own exceptions.
Inputs Stream and Output Stream: Streams, Byte an Character stream, Predefined stream.
Reading and Writing from console and files, Buffered Reader and Writr, Serialization, Data
Compression using standard JAVA packages (lang, util, io, net)
Database : JDBC architecture, JDBC basics, JDBC drivers, Connecting to database and
accessing databases
AWT and Event Handling: Creating user interface with AWT, Applets, Applet life cycle,
simple graphics, Fonts and colors, events, listeners, components, containers, working with
layouts, image processing, AWT exceptions, Delegation event model, event classes, event
listener interfaces, adapter and inner classes.
Unit III
Multithreading and Communication: JAVA thread Model: Priorities, synchronization,
messaging, life cycle of thread, thread class, runnable interface, interthread communications,
suspending, resuming and stopping threads. Multithreading, synchronization, scheduling and
priority of threads, sockets, types of sockets, working with URLs, web browsers and handlers.
Unit IV
JAVA Basics: Importance and features of JAVA, modifiers, access controls, data types,
expressions, declarations, statements and control structures, programme structures, string
handling, packages, interfaces, working with JAVA, util packages, garbage collection, object
class.
Bio JAVA: Installing BioJAVA, symbols, basic sequence manipulation (DNA to RNA, Reverse
complement, motif as regular expression ) , Translation ( DNA to Protein, codon to amino acid,
six frame translation ) Proteomics ( Calculate the mass and pl of a peptide), sequence I/O ( file
formats conversions), locations and features ( Point location, range location, feature
modifications) BLAST and FASTA ( Blast and Fast A parser, extract information form parsed
results), counts and distributions, weight matrices and dynamic programming, user interfaces.
Unit V
Web Publishing: Internet –WWW- Browswer – Designing web site – Basics of creating a web
page with HTML – Linking – Text formatting – Adding Images and background to HTML pages
– Tables – Image maps.
Text Books:
1. R.Lahore, Object Oriented Programming using C++
2. Patrick Naughton and Herbertz Schildt, JAVA -2 The complete reference, TMH edition
3. Horstman, Computing concepts with JAVA -2Essentials, John Eiley
4. E. Balaguruswamy, Programming with JAVA
5. G. Booch, Object oriented Design and Applications
6. Monica D‟Souza & Jude D‟Souza “Web Publishing” –(2001) TMH
Reference Books:
1. Object Oriented Programming in C++ - Robert Lafore, Galgotia
2. Let us C++ - Yeshwant Kanetkar – BPB
3. Instant HTML Programmer‟s Reference – Steve Wright – WROX Press Ltd.
P.G. DIPLOMA IN BIOINFORMATICS
SEMSTER II
Paper V (DB-05) – Database Management Systems
Unit I
Data base : Introduction – Basic Technology and Data Basics – Objective of a Data base
organization – Entities & Attributes.
Unit II
Data Models : Introduction – Schemes & Sub Schemes – Data Base Management Systems – Tre
Structures – Plex Structures – Relational Databases – Normal Forms.
Unit III
Data Base Languages : Introduction – Data Description Languages – the CODASYL Data
Description Language – Query Languages – Data Dictionaries.
Unit IV
Physical Organization: Introduction – Criteria affecting physical organization- Differences
between physical & logical organization – Addressing Techniques – Index sequential
organization – Hashing.
Unit V
Pointers – Chains & Ring Structures: Introduction – Physical representation of tree structures –
Physical representation of plex structures – Virtual & Storage hierarchies.
Text Book:
1. James Martin, Computer Database Organization, Prentice Hall of India.
Reference Books:
1. James Martin, Principles of Database Management, Prentice Hall of India
2. C.J. Date, An Introduction to Database systems, 3rd
edition, Narosa Publishing House.
Paper VI (DB-06) – Biophysics
Unit I :Introduction
Levels of structure in biological macromolecules, Central questions in biophysics, basic
strategies in biophysics.
Unit II :Conformational Analysis
Forces that determine protein and nucleic acid structure, basic problems, polypeptide chain
geometrics, potential energy calculations, observed values for rotation angles, hydrogen bonding,
hydrophobic interactions and water structure ionic interactions, disulphide bonds.
Unit III : Structural Analysis of Macromolecules
Prediction of protein structure nucleic acids, general characteristics of nucleic acid structure,
geometrics, glycosidic bond rotational isomers and ribose puckering backbone rotational isomers
and ribose puckering forces stabilizing ordered forms, base pairing, base stacking tertiary
structure of nucleic acids.
Unit IV :Kinetics of ligand Interactions
Biochemical kinetics studies, unimolecular reactions, simple biomolecular multiple
intermediates, steady stake kinetics, catalytic efficiency, relaxation spectrometry, ribonuclease as
an example.
Unit V : Techniques for Study of Biological Structure and Function
Size and shape of macromolecules – method of direct visualization – macromolecules as
hydrodynamic particles – macromolecular diffusion- ultracentrifugation – viscometry x-ray
crystallography determination of molecular structure x-ray fibre diffraction electron microscopy
neutron scattering – light scattering.
Reference Books:
1. C.R. Cantor & P.R. Schimmel, Biophysical Chemistry Part- I,II & III, W.H. Freeman &
Co., in San Fransisco, 1980.
2. C. Branden and J. Tooze, Introduction to Protein Structure, Garland Publishing Inc., New
York., 1991.
3. R. Glaser, Biophysics, Springer, 2000.
Paper VII (DB-07) – Genomics and Proteomics
Unit I
The genetic material – Identification of genetic material, genetic code, concept of gene – operon
concept – lac and trp operons, promoters and repressors.
Unit II
Genomics – definitions- pharmacogenomics – taxicogenomics – prokaryotic and eukaryotic
genome – genome relationships – human genomics – EST Analysis, c-DNA Library, Consensus
sequence.
Unit III
Genomics methodologies : Whole genome analysis – Physical methods of sequencing –
automated sequencing – genome expression and analysis- serial analysis- oligo NT array
technology – code micro assay and micro chips.
Unit IV
Proteomics: Definition – Transcriptomics: Proteomics, metabolomics, Techniques of proteomics
– 2D PAGE, Multidimensional protein identification (Mud PIT) Isotopically coded affinity Tag
(ICAT), Mass spectrophotometer – (MALDI-TOF) MS. Application of functional genomics in
basic biology, target /Marker identification, target valediction/ toxicology, microbial drug
resistance, tumour immunology, vaccine discovery, drug design.
Unit V
A brief account of genetic engineering and protein engineering.
References:
1. Baxevanis AD and B.F.F. Ouellette, Wiley Bioinformatics – A practical guide to the
analysis of genes and proteins. (ed) – Interscience, New York, 2001.
2. Doolittle RF (1990). Molecular evolution. Computer Analysis of Protein and Nucleic
acid Sequences, Methods in Enzymology, Academic Press, New York.
3. Faber K (1992) Biotransformation in Organic Chemistry, Springer Verlag.
4. Gerbardt P. Murray RG, Wood WA, Kreig NR (1994) Methods for General and
Molecular Bactriology – American Society for Microbiology Washington D.C.
Paper VIII (DB-08) – Computational Biology
Unit I
Structure of DNA & Protein – Sequence analysis – pair wise sequence comparison- sequence
queries against biological databases – BLAST and FASTA – multifunctional tools for analysis.
Unit II
Multiple sequence alignments, Phylogenetic alignment – profiles and motifs-distance and
similarity – evolutionary basis of sequence alignment – scores and gaps.
Unit III
Protein structure visualization – tools structure – classification, alignment and analysis, Solvent
accessibility and Interactions – Physico chemical properties, structure optimization. Protein
resource databases.
Unit IV
Predicting Protein structure and function from sequence- Determination of structure – feature
detection – secondary structure prediction- predicting 3D structure. Protein modeling.
Unit V
Genomics and Proteomics – Sequencing genomes – sequence assembly – genome on the web –
annotating and analyzing genome sequences. Proteomics - biochemical pathway databases –
submitting sequence to the databases.
Reference:
1. Bioinformatics: A practical guide to the analysis of genes and proteins- 2001 – AD
Baxevanis & BFF Ouellette – Wiley Interscience – New York.
2. Bioinformatics : Methods and Protocols – 2000- Stephen Misener & Stephen A. Krawetz,
Humana Press, New Jersey.
3. Bioinformatics: Sequence, structure and databanks – 2000- Des Higgins & Willie Taylor
– Oxford University Press.
Paper IX (DB-09) – Elective
A):Commercial Applications of Bioinformatics
Unit I
Commercial Bioinformatics, Definition of Bioinformatics Company, Genome Technology; high
throughput sequencing and assembly.
Unit II
Micro arrays and genome wide expression analysis; transcriptome, proteome, Genomics in
medicine, diseases monitoring, profiles for therapeutic molecular targeting.
Unit III
Diagnostics drug discovery and genomic. Pharmacogenomics and its applications. SNPs and
their applications.
Unit IV
Proteomic in medicine and therapeutic target identification. Comparative Proteomics and its
applications.
Unit V
Patenting and data generation from patent literature for commercial benefits. IPR and
Bioinformatics. Bioinformatics patents.
Reference:
1. Drug Discovery Today, Trends journals.
2. Functional Genomics, http://WWW. Functionalgenomics.org.uk/
B):Molecular Modeling and Drug Design
Unit I
Recent advances in drug design methodologies, Biomolecular structure, Structure activity
relationship, Pharmacokinetics, structure – based drug design.
Unit II
Pharmacophoric pattern, ADME Properties, quantitative structure activity relationship, Use of
genetic algorithms and principle component analysis in the OSAR equations.
Unit III
Molecular modeling, quantum mechanical and molecular orbital methods, introduction to semi-
empirical, molecular mechanics and ab intio techniques. Simulation techniques, potential energy
surfaces, docking and modeling substrate – receptor interactions.
Unit IV
Software tools for modeling bio – molecules. Molecular electrostatic potentials, charge analyses.
Protein conformations, folding and mutation through modeling.
Unit V
Use of genomics and Proteomics for understanding diseases at molecular level strategies for
target identification and lead design.
Reference Books:
1. Andrew Leach, Molecular Modeling: Principles and Applications (2nd
Edition), Addison
Wesley Longman, Essex, England, 1996.
2. Alan Hinchliffe, Molecular Modeling for Beginners, John – Wiley, 2003.
3. N. Cohen (Ed.), Guide Book on Molecular Modeling in Drug Design, Academic Press,
San Diego, 1996.
C):Biodiversity Informatics
Unit I
Biological information: Biological diversity of life, Species diversity: taxonomic information
on plants, animals, microbes and viruses, Genetic diversity, Ecological/ Ecosystem diversity.
Urban biodiversity, Methods for species identification and classification.
Unit II
Biodiversity Databases: Organizing biological species information, Datasets in biodiversity
informatics: specis 2000,Tree of life, ATCC, NBII, Species analyst collaboration, ICTV, Animal
virus information system etc.
Unit III
Software for identification: Accessing existing databases on the World Wide Web.
Unit IV
Software for identification of species: Probabilistic and deterministic identification, Delta,
MicrolS, AVIS, ICTV
Unit V
Biocomplexity issues in Biodiversity: Need of metadata standards and ontology
Reference:
Pankhurst, R. J. Practical taxonomic computing, 1991.
Practical – I (DB-PR-01) C++ Programming and Web Publishing Lab
1. Factorial of a given number
2. Sorting and merging two arrays of numbers.
3. Sorting names in alphabetical order
4. Reversing a given string
5. Checking for palindrome
6. String Manipulation – String copy, String length, String Concatenation, String
comparison and String reverse.
7. Mean, median, mode and standard deviation calculations.
8. Stroing and retrieving amino acid sequences using structure data types
9. File Processing – Creation and simple processing
10. Computing amino acid composition of a given protein sequence.
JAVA:
Concept of flowcharting, Algoriths development, Pseudo codes, working with objects,
Arrays, conditional and loops, creating classes and applications in JAVA, JAVA Applets
basics, graphics, fonts and color, simple animation and thread, advanced animations, images
and sound, managing simple events and interactivity, creating user interface with AWT,
modifiers, networking and other class, designs, packages and interfaces, exception,
Multithreading stream and I/O, Using native methods and library, JAVA programming tools,
Working with Data structure, Images filters.
Web Publishing:
1. Create a web page for your University / College using HTML. The opening page should
provide hyperlinks to other pages (add animation and sound effects appropriately.)
2. Creating a web page to get protein sequence data and compute and display amino acid
composition.
3. Creating a web page to get nucleic acid sequence data and compute and display base
composition.
Practical –II (DB-PR-02) Mini Project
Practical –III (DB-PR-03) Bioinformatics Lab
1. Study of Internet resources in Bioinformatics. E.g. NCBI, CGEB, EMBL.
2. Searches on MEDLINE, Pub Med and CDROM bibliographic databases Concept of
Boolean operators in searching.
3. Introduction to sequence data bases
Protein sequence databank, NBRF –PIR, SWISSPROT, EMBL.
Nucleic acid sequence databank – Gene bank, EMBL
4. Pair wise alignment – Needleman- Wunsch and Smith – Waterman algorithms
5. Multiple alignment- CLUSTALW & PRINTS
6. BLAST,FASTA programs for sequence database search
7. Genome data bank – study the features of human genome.
8. Evaluation of protein structure by Swiss PDB viewer and by other molecular
Visualization tools.
9. Calculation of phi – psi angles – Ramachandran plot.
10. Homology modeling of a given protein sequence.
Practical – IV (DB-PR-04)- Project
5) Syllabus for Certificate Course in Mobile Repairs
(Funded by UGC under Career Oriented Programme)
Paper –I : Mobile Concepts and Basic Electronics
Period Hours :60
Marks :100
Chapter-1
Introduction and Types of Mobile phone Technology, GSM, CDMA & 3G
Mobile phones, Basic Information about Conductors, Insulators, Semiconductors,
Current, Voltage, Resistors, Ohm‟s Law, AC/DC, Multimeter and its uses.
Chapter-2
Resistors and its types, Capacitors and its types, Diodes and its types, Transistors
and its types, Inductor/ Coil, Transformer, Power Switch, Real Time Clock and Quartz
Crystal Rectifier circuits and its types, Introduction to IC‟s Chips and Microprocessors
used in Mobiles.
Chapter-3
Information about various mobile Handsets, Functions and features of Handsets,
information about all spare parts of mobiles, Mobile accessories, Technical
terms/Abbreviations/Codes used in mobile phones, Information about phone settings,
Network services, Security settings, LCD settings etc.
Chapter-4
SIM Card, Functions features and uses of SIM Cards, Mobile Batteries, Use of
Battery Booster, Jhatka Machine, Basic and Special Components of Mobile Phone, Tools
and equipments required for repairing, Uses of Blower (SMD), Screw Driver Set, Brush,
Jumper wire, Soldering wire, Assembling and dismantling of different mobile handsets.
Paper –II : Mobile Problems and its Repairs
Period Hours :60
Marks :100
Chapter-1
Block diagram of Mobile Handset, Circuit diagrams of Mobile phones, Working
Principal of Mobile. Safety and precautions, Practical Testing of Basic Component by
Multimeter. Searching the Processor in Different types of Mobile.
Chapter-2
Tracing Techniques, Circuit Tracing of Different Section of Mobile Phone.
Charging Section, Network Section, Keypad Section, Display Section, Speaker and
Ringer Section, Blue Tooth Section, Infra red Section, Light Section, Mic Section,
Checking the Basic Component of Mobile Phone and its Faults.
Chapter-3
Voltage Tracing and different volts used in Mobile Phone. Checking Shorting and
Technique to Remove. Hot and Cold Testing. Water Damage and Washing of Mobile
Phone with CTC.
Chapter-4
Soldering and Desoldering techniques, Technique of Soldering and using SMD
Rework Station, Jumpers and its Technique. Construction of Battery Booster, Charger
and its uses Fault find related to Software, (Ex.-Sim locked, Sim rejected, Hanging
problem, Restart problem) etc., Fault find related to Hardware, (Ex.-Dead, Network
problem, Simcard rejected, Mic/Speaker not working, No charging, No vibration) etc.
fault finding and repairing.
Paper –III : Softwares, downloading and Flashing
Period Hours :60
Marks :100
Chapter-1
Basic Computer Knowledge, Introduction of Mobile softwares, Internet sites for
Mobile software, downloading & adding tones,
Chapter-2
Application Software Training ( Ring Tones, Games, Wall Papers, & Other
Spider Box Training (For Chinese Phones), Ve-pro Box Training ( For Chinese Phones),
U.f.s Repairing Box Training, Micro Box Training ( For Latest Multimedia Sets), Infinity
Box Training ( for Motorola, L.G., Chinese & 150 Other Phones), S.E. Tool Box
Training. ( For Sony Ericsson Sets) Universal Box Training ( Spl. For I.M.E.I Repairing)
Chapter-3
Installing and Removing Connector, Display flex, Folding and Sliding Handset
Flex Cable, Flashing and its Related Faults, Different Types of Flasher Box, Flashing and
Formatting through UFS HWK Flasher Box, SPIDERMAN BOX,
Chapter-4
Knowledge about IMEI, IMSI, ESN, PIN, PUK, MTSO, SECURITY LOCK,
DEFAULT CODES OF DIFFERENT MOBILES, Factory Restore. Software :- Like
Smart Movie Converter, I-phone Video Converters, I-phone Unlocking, I-pod Loading.
Paper –V : Practical Paper -1
Period Hours :50
Marks :50
Minimum 10 experiments to be performed amongst the following:
1. Study of Multimeter and testing of given components.
2. Testing of SIM Tray and repairing it of a given mobie.
3. Testing of Battery connector and charging section and replacing and repairing in a given
mobile.
4. Display connector tracking, testing and repairing of a given mobile.
5. Network section tracking, testing and repairing of a given mobile.
6. MIC, Speaker, Ringer and vibrator testing and repairing.
7. Identification of power chip and Microprocessor chip and replacement of a given mobile.
8. Memory card reader (Black & Silver) replacement in a mobile.
9. Study of keypad section and replacement of keypad IC chip in a mobile.
10. SIM Reader IC chip replacement and fault finding in a mobile.
11. Headphone IC chip replacement and fault finding in a mobile.
12. Bluetooth IC chip checking and replacement in a given mobile.
Paper –VI : Practical Paper -2
Period Hours :50
Marks :50
Minimum 10 experiments to be performed amongst the following:
1. Installation of a flashing software in a computer and knowledge about its versions.
2. Use of Internet to download software‟s and flashing the given mobile.
3. Downloading of songs, Wall papers and ringtones on given memory card.
4. Formatting and recovery of data on memory card.
5. Identifying the problems related to hang of a mobile and flashing it.
6. Study of HWK Box and flashing in NOKIA mobiles.
7. Study of SPIDERMAN and AVATOR Box and flashing in China mobiles.
8. Study of JAF Box and flashing in NOKIA mobiles.
9. Study of Z3X Box and flashing in SAMSUNG mobiles.
10. Study of TURBO Box and flashing in NOKIA mobiles.
11. Study of MAX Key Box and flashing in NOKIA mobiles.
12. Study of T Mobile and DOCTOR Box and flashing in NOKIA mobiles.
6) Syllabus for Certificate Course in Drug Analysis
UGC- Career Oriented 1 year Certificate Course For Under Graduate Students
B.Sc. First Year-Drug Analysis
Paper Course No. Course Periods/
Week
Total
Periods
Marks
I CH- 101 Techniques in drug analysis 2 80 100
II CH-102 Medicinal Chemistry 2 80 100
III CH-103 Uses and application of drugs 2 80 100
IV CH-104 Laboratory Course –I 4 120 100
B.Sc. First Year
Paper-I (CH-101)
Drug Analysis
(Techniques in Drug Analysis)
Marks :100
Periods: 80
1.Introduction:
Significance of quantitative analysis in quality control, need for quality system, different
techniques of analysis, significant figures, Types of errors, Selection of sample, precision and
accuracy. Fundamentals of volumetric analysis, methods of expressing concentration,
primary and secondary standards. Definitions: Solute, solvent, solution, equivalent weight,
parts per million, parts per billion, molarity, molality, normality. Calibration of volumetric
apparatus, balances and weight box. Stoichiometric calculations – Concentration of solution,
Molarity, Normality, Expression of analytical results and factor calculation in all types of
titrimetric analysis.
2.Acid Base Titrations:
Acid base concepts, Role of solvent, Relative strengths of acids and bases, Ionization,
Law of mass action, common ion effect, Ionic product of water, pH, Buffer solutions, Acid-
base indicators, Theory of indicators, Choice of indicators, mixed indicators, preparation and
standardization of 1N NaOH, 1N H2SO4, 1N HC1 and 1N Na2CO3
3. Non aqueous solvents and their classification with examples, theory, Indicators(excluding
structures), factors affecting non aqueous titrations.
4.Oxidation Reduction Titrations:
Concepts of oxidation and reduction, theory of oxidation-reduction titration, oxidation
reduction indicators (Self indicator, redox indicator) Iodimetry and Iodometry, Titrations
involving ceric sulphate, potassium iodate, potassium bromated, potassium permanganate;
titanous chloride.
5.Argentimetric titrations:
Solubility product, Theory of precipitation, titration curve, Factors influencing solubility
of precipitate, detection of end point, Mohr‟s method Volhard‟s method, Fajan‟s method
preparation and standardization of 0.1 N AgNO3 and 0.1M ammonium thiocyanate. Assay of
Sodium Chloride and Potassium Chloride I.P.
6.Sodium nitrite Titrations:
Theory Preparations and standardization and of 0.1 N NaNO2
Assay of Sulphanilamide I.P., Sulphadiazine I.P.
7.Density measurement:
Introduction, measurement of density of liquids, Applications.
8.Refractometry:
Refractive index, Snell‟s law, factors affecting refractive index, specific refraction, molar
refraction, instrumentation, and applications.
9.Polarimetry:
Optical activity, instrumentation, and applications.
10.Chromatography:
The following techniques will be discussed with relevant examples of Pharmacopoeial
products. TLC, HPLC, GLC, HPTLC, Paper Chromatography and Column Chromatography.
References:
1. Chatwal and Anand, Instrumental methods of chemical analysis, Himalaya publishing
2. Parimoo, Pharmaceutical Analysis, CBS Publishing.
3. Practical Pharmaceutical Chemistry, Part I and II by Beckett and Stenlake. (CBS)
4. Vogel‟s Text Book of Qualitative Chemical Analysis, 5th
edition (Longman Pub.)
5. Indian Pharmacopoeia Vol-I and II (1996)
6. Juran‟s, Quality Control Hand book (McGraw)
7. Text book of pharmaceutical Analysis, K.A. Connors(John Wiley)
B.Sc. First Year
Paper-II (CH-102)
Drug Analysis
(Medicinal Chemistry)
Marks :100
Periods: 80
1.Introduction:
Important terminology, rout of administration, drug absorption, Distribution, elimination
absorption. Distribution, elimination. Development of new drugs. Physicochemical properties in
relation to biological action – Solubility, partition coefficient, Ionization, complexation,
hydrogen bonding, surface activity, redox potential. Steric properities in relation to biological
action – Optical isomerism, Geometric isomerism, Conformational isomerism and Bioisosterism.
Drug receptor interaction – Receptor and their types, forces involved in drug receptor complexes.
2.Nomenclature:
Synthetic procedures of selected drugs, mode of action, uses, structure activity
relationship including physicochemical properties of sthe following classes of drugs:
a) Synthetic antibacterial agents -
i)Topical antibacterial agents
ii)Systemic synthetic antibacterial agents
Norfloxacin, Ciprofloxacin, Sparfloxacin
b) Antimalarial agents -
Life cycle of malarial parasite, chloroquin, amodiquin, primaquin, pyrimethamine,
cycloguanil.
c) Antimycobacterial agents –
i)Antitubercular agents.
First line and Second line drugs, combination therapy for tuberculosis.
INH, Ethionamide, Ethambutol, PAS, Clofazimine.
ii)Antileprotic agents: Dapsone
d) Antifungal agents –
Clotrimazole, Tolnaftate, Flucytocine.
Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents.
Diuretics: Acetazolamide, Furosemide, Hydrochlorthiazide.
3.Vitamins – Classification and their role
4.Drug metabolism and Concepts of Prodrugs
References:-
1. Wilson & Gisvold‟s Text book of organic, Medicinal and pharmaceutical Chemistry,
Lippoincott.Co.
2. M.E. Wolff, Brugers Medicinal Chemistry Vol. I to V, John Wileys & Sons.
3. Indian Pharmacopoeia
4. Finar I.L., Organic Chemistry Vol. II, ELBS Publication.
5. William & Smith, Drug design series.
6. W.C. Foye, Principles of Medicinal Chemistry, Lea and Febiger.
B.Sc. First Year
Paper-III (CH-103)
Drug Analysis
(Uses and application of Drugs)
Marks :100
Periods: 80
1.Introduction:
i) Atomic Structure:
Bohr‟s model, Wave nature of electrons, Schrodinger‟s Wave equation, Quantum
number, Geometry of Orbitals.
ii) Nature of Chemical Bond:
Ionic, Covalent, hydrogen, Co-ordinate, valence bond & Molecular orbital theory.
iii) Co-ordination Chemistry:
Co-ordinate bond, structure of co-ordinate complexes, stability of complexes,
chelation, crystal field theory and ligand field theory.
An outline of methods of preparation, uses, sources of impurities, tests for purity and
identity, including limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate
and special tests if any, of the following classes of inorganic compounds. Acids and
Bases: Buffers, Water.
2.Gastrointestinal Agents:
Acidifying agents, Antacids, Protectives and Adsorbents, Cathartics.
Major Intra-and Extra-cellular Electrolytes: Physiological ions. Electrolytes used for replacement
therapy, acid-base balance and combination therapy.
3.Essential and Trace Elements:
Transition elements and their compounds, Iron and haematinics, mineral supplements.
4.Cationic and anionic:
Components of inorganic drugs useful for systemic effects. Topical Agents: Protectives,
Astringents and Anti-infectives. Gases and Vapours: Oxygen, Anesthetics and Respiratory
stimulants. Dental Products: Dentifrice, Anti-caries agents.
5.Complexing and chelating agents:
Used in therapy Expectorants, Emetics & Antitussives: Antidotes: cyanide poisoning
6.Inorganic Radio Pharmaceuticals:
Nuclear radio pharmaceuticals, Reactions, Nomenclature, Methods of obtaining their
standards and units of activity, measurement of activity, clinical applications and dosage, hazards
and precautions.
Reference:-
1. Bently and Drivers, Text Book of Pharmaceutical Chemistry.
2. Remington‟s Pharmaceutical Sciences,
3. Pharmacopoeia of India
4. A.H. Beckett & J.B. Stanlake, Practical PharmaceuticalChemistry, Part I & II
5. J.D. Lee, Concise Inorganic Chemistry, ELBS Publication
6. Alexive V.N., Qualitative Chemical Semimicro Analysis, CBS Publication
7. J.S. Qadry, A Text Book of Inorganic Pharmaceutical and Medicinal Chemistry, B.S.
Shah Prakashan.
8. Vogel‟s Qualitative Inorganic Analysis, Orient Longman
9. J.H. block, E.B. Roche, T.O. Soine, C.O. Wilson, Inorganic Medicinal and
Pharmaceutical Chemistry, Lea and Febiger, Philadelphia.
B.Sc. First Year
Paper-IV (CH-104)
Laboratory Course - I
(Medicinal Chemistry)
Marks :100
Periods: 120
Note: At least twelve experiments should be taken.
1.Only Demonstration:
i) Seperation of benzene and water by distillation method.
ii) Determination of Rf values in chlorophyll pigments.
2.Qualitative Analysis: (At least 04 practicals)
Seperation and identification of given binary organic mixtures.
3.Quantitative Analysis : (At least 02 practicals)
i) Estimation of formaldehyde
ii) Estimation of glycine by sorenson‟s method
iii) Estimation of amide
4.Synthesis of Drugs: (At least 06 practicals)
a) Synthesis of phenytoin
i) Synthesis of benzil from benzoin
ii) Synthesis of phenytion from benzil.
b) Synthesis of benzaldehyde from benzophenone.
i) Synthesis of benzophenone oxime from benzophenone
ii) Synthesis of benzophenone oxime.
c) Synthesis of Aspirin from salicylic acid (By Acetylation)
d) Synthesis of o-chlorobenzoic acid from anthranilic acid (Sand mayer reaction)
e) Synthesis of chlorimine -T
f) Synthesis of D.D.T.
g) Synthesis of fluroscein from phthalic anhydride.
Referernces:-
1. Practical Pharmaceutical Chemistry, Part I and II by Beckett and Stenlake.(CBS)
2. Vogel‟s Text Book of Qualitative Chemical Analysis, 5th
edition (Longman Pub.)
3. Practical hand Book of Vishnoi Volum I and II.
B.Sc. First Year
Paper-V (CH-105)
Laboratory Course -II
(Techniques in Drug Analysis)
Marks :100
Periods: 120
Note: At least twelve experiments should be taken.
1.Introduction to Drug Analysis:
i) To Study the analytical apparatus and basic techniques in drug analysis laboratory.
ii)To calibrate analytical apparatus, balance and weight.
2.Acid Base Titration:
i) To prepare and standardize 1M HCI as per I.P.
ii)To prepare and standardize 5M NaoH as per I.P.
iii)To perform asssay of given sample of NaHCO3 as per I.P.
iv)To perform asssay of given sample of Aspirin as per I.P.
3.Oxidation Reduction (Redox) Titration:
i) To prepare and standardize 0.02M Kmno4 as per I.P.
ii)To prepare and standardize 0.05M Iodine as per I.P.
iii)To perform asssay of given sample of H2O2 as per I.P.
iv)To perform asssay of given sample of Ascorboic acid as per I.P.
4.Polarimetry:
i) Measurement of specific rotation.
ii)Quantitative analysis of Dextrose injection.
5.Refractometry:
i) Refractive index measurement in identification and quantitative analysis.
ii)Critical micell concentration (CMC) detrmination by refractometry.
6.Semi Quantitative analysis:
i) Limt test for chlorides, sulphate.
ii)Limt test for arsenic and Iron.
References:-
1. Practical Pharmaceutical Chemistry, Part I and II by Beckett and Stenlake. (CBS).
2. Vogel‟s Text Book of Qualitative Chemical Analysis, 5th
edition (Longman Pub.)
3. Practical hand Book of Vishnoi Volum I and II.
4. Vogel‟s Qualitative Inorganic Analysis, Orient Longman.