1. gregor mendel genetics =the branch of biology that deals with heredity. a great deal of what we...
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Gregor MendelGregor MendelGenetics =the
branch of biology that deals with heredity.
A great deal of what we know about genetics began with the work of a monk named Gregor MendelGregor Mendel, who experimented with sweet pea plants in the 1800s. 22
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Mendel’s Work
•Mendel studied the patterns of inheritance in pea plants.
•He chose seven traits to follow.
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•Mendel needed to make sure he had plants that always gave the same offspring-called true breeding.
•He “self-pollinated” plants until he got seeds that always gave the same offspring.
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He took a purple flower plant and crossed it with a white flower plant.
He called these the parent generation (P1 generation)
What do you think the offspring (the F1 generation) looked like?
ALL PURPLE
X
Pollen
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POLLEN
SAY SAY
WHAT??????
WHAT??????
??
F1
F266
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Mendel concluded:1. Something is being passed
from parent to offspring. 2. Sometimes you can see
“it” and sometimes you can’t.
3. If you can see “it”- “it” is dominant.
4. If “it’s” there and you can’t see “it”- it’s recessive.
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1. Dominant alleles are shown using a capital letter (R)
2. Recessive alleles are shown using a lower case letter (r)
Examples: R=red r=pinkRR - ?Rr - ?Rr- ?Each version is called an allele.
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Alleles are locted on genes on chromosomes.
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Law of DominanceLaw of Dominance
States that the dominant allele States that the dominant allele will will preventprevent the recessive the recessive
allele from being expressed. allele from being expressed. The recessive allele will The recessive allele will onlyonly appear when it is paired with appear when it is paired with
another recessive allele in another recessive allele in the offspring.the offspring.
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We have two copies of all of our chromosomes Why?
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BOY OR GIRL?
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What is a gene?What is a gene?• A segment on the chromosome A segment on the chromosome
that codes for a protein.that codes for a protein.• People have two copies of each People have two copies of each
gene, one copy inherited from gene, one copy inherited from the the mothermother and the other copy and the other copy inherited from the inherited from the fatherfather. .
• There are many versions of There are many versions of each gene-alleleseach gene-alleles
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If the two alleles in the pair are
identical, then the condition called homozygous.
•
If the 2 alleles are different, the condition is called heterozygous. The term “hybrid” is sometimes used to refer to heterozygous.1616
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Genotype: the
genes or alleles
(RR, Rr, rr)
Phenotype: an organisms physical appearance (Red, White)
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How did you end up with the traits and genes that you got?
During meiosis, each egg or sperm only gets one copy of each chromosome.
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Law of Segregation (separation) states that gene pairs separate when gametes (sex cells) are formed, so each gamete has only one allele of each gene pair.
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A
b
a
B
A
b
a
B
A
b
a
B
A
b
a
B
A
b
a
B
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Law of Law of Independent Independent AssortmentAssortment states that
different pairs of genes separate
independently of each other
when gametes are formed.
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Example:
Just because you get the gene for brown hair does not mean you will get the gene for blue eyes.
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REVIEWREVIEW1. A trait is a characteristic an individual receives
from its parents. 2. Genes carry the instructions responsible for the
expression of traits. 3. A pair of inherited genes controls a trait. 4. One member of the pair comes from each
parent.5. Alternative versions of genes are known as
alleles.
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REVIEWMendel’s Principles of Inheritance
• Inherited traits are transmitted by genes which occur in alternate forms called alleles
1. Principle of Dominance - when 2 forms of the same gene are present the dominant allele is expressed
2. Principle of Segregation - in meiosis two alleles separate so that each gamete receives only one form of the gene
3. Principle of Independent Assortment - each trait is inherited independent of other traits (chance)
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Punnett Squares• Used to determine the probability
of a combination of alleles• Example: If a heterozygous black
rabbit is crossed with a heterozygous black rabbit, what are the chances the offspring will be black?
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B=Black
b= Brown
Genotypes?
Phenotypes?
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Example EOCT Question:Example EOCT Question:Earlobe shape is a human trait. Some people have free earlobes while others
have attached earlobes. Two parents with free earlobes have four children. Three
children have free earlobes and one child has attached earlobes. If these parents
have another child, what is the probability that the child will have attached earlobes?
A 25%
B 50%
C 75%
D 100% 2626
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Example EOCT question:
In humans, a widow’s peak is dominant over a continuous hairline. Mary’s father has a widow’s peak, but Mary and her mother have a continuous hairline. What is the genotype of Mary’s father?
A HHB HhC hh D cannot be determined
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Incomplete dominance
- cross between
organisms with two
different phenotypes that
produces offspring with a
third phenotype that is a
blendingblending of the parental
traits.
Ex. Red and White = Pink 2299
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Incomplete Dominance
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CodominanceCodominance• a cross between organisms with two different phenotypes
produces offspring with a third phenotype in which both of the
parental traits appear together.
• Ex: Yellow and Orange = yellow with orange spots
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CodominanceCodominance•Both
phenotypes are expressed at the same time.
•Example: Blood
Types
Genotype Phenotype
IOIO Type O
IAIO Type A
IAIA Type A
IBIO Type B
IBIB Type B
IAIB Type AB
There are 3 alleles for blood type- multiple alleles
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CodominanceR = allele for red flowers
W = allele for white flowers W = allele for white flowers red x white ---> red & white spotted
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Polygenic traitsMost traits are controlled by many
genes, not just one.Examples: hair color and skin color.
There are several genes that control them.
This is the reason that there are so many different colors of hair and
skin in humans.
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Sex Linked TraitsTraits associated with
particular sexes are called sex-linked or X-linked traits. These are usually carried on
the X chromosome. Females = XX
Males = XY
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KaryotypKaryotyp
ee
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1st 22 are Autosomes, the last pair (XY) are sex chromosomes)
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Charts that show relationships within a
family
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Pedigr
ee
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Autosomal -Dominant
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Genetic
Disorders
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Huntington’s Disease
• Huntington's disease degenerative disease that causes certain nerve cells in your brain to waste away.
• you may experience uncontrolled movements, emotional disturbances and mental deterioration.
• The disorder was documented in 1872 by American physician George Huntington.
• Fatal----ages:30-60
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Colorblindness
•Sex-linked trait• Gene for color vision located on
the X chromosomes.• MalesMales are more likely to have
colorblindness because they have only one X chromosome
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What do you see?
The individual with normal color vision will see a 5 revealed in the dot pattern. An individual
with Red/Green (the most common) color blindness will see a 2 revealed in the dots.
What What
do do
you you
see?see?
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Down SyndromeDown Syndrome• Three copies of chromosome #21.
• Symptoms: mental retardation and some physical deformities
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Down’s Syndrome – How do you get 3 copies of chromosome 21?
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Nondisjunction – failure of chromosomes to separate properly during cell division
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Cystic Fibrosis• caused by a recessive
allele on chromosome #7.
• Deletion of three bases.
• Affects the body's respiratory and digestive systems.
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HemophiliaSex-liked,
recessive
trait
Located on
the X
chromosome
Missing a
protein
necessary
for blood
clotting
Can bleed
to death
from minor
cuts.
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Queen Victoria’s Pedigree showing Hemophelia
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Sickle Cell
People who carry the tendency to have sickle cell anemia are less likely to die from malaria.
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Gene Therapy
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The insertion of healthy genes into an individual’s cells or tissues to treat a disease.
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Example EOCT question:Example EOCT question:
What is nondisjunction?
A. failure of chromosomes to separate during meiosis
B. failure of the cytoplasm to divide properly
C. the insertion of a gene into a different chromosome
D. the deletion of a gene from a chromosome
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Which of the following shows how information is
transformed to make a protein?
A DNA RNA proteinB gene chromosome proteinC cell respiration ATP proteinD ATP amino acid protein
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Information on mRNA is Information on mRNA is used to make a sequence used to make a sequence
of amino acids into a of amino acids into a protein by which of the protein by which of the
following processes?following processes?A replicationB translationC transcriptionD transference
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Pea plants have seeds that are either round or wrinkled. In this cross, what will be thephenotypic ratio of the offspring?
A 50% RR and 50% RrB 25% RR, 50% Rr, and 25% rrC 50% round seeds and 50% wrinkled seedsD 100% round seeds
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What is a source of genetic variation?A mutationB adaptationC replicationD transcription
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A homozygous traitB dominant traitC recessive traitD heterozygous trait
In Mendel’s experiments with a single trait, the
trait that disappeared in the first generation
and reappeared in the next generation is called
the
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