. . , , ,

- *

- ,

**

1

(7 - 8 ; 5.1012/L). , ( ). ~ 120 .

5.2 0.3.1012/L 4.7 0.3.1012/L - 160 20 g/L 140 20 g/L 0,40 0,54 0,36 0,47

- , / , .

(, -) (. 12)

.

- - - - ()- - - -

( )

( )

( )

- - ( + ) () , , (, , )

Hb , Ers , Hct

, - ( ) , B12 Fe

*(, , , ) .

-

: Adisson Biermer ( ) ( )

HLA-A3, HLA-B7 : 12

- Addison-Biermer

( ) (, , )

, , , . , , () Ers ( ) -

Er (M. Minkowski-Chauffard)

Ers-6- - - - -

Icterus gravis Rh Rh- Rh+ 1 2

Rh -

- (-thalassemia mayor) - (-thalassemia minor) - -

Thalassemia mayor (M. Cooley) HbF HbA2 - - - Ers

OXY-DEOXY- - , S

I

II

. : , ()

, . .

:

:

. 3 :

( VIII) B ( IX) C ( XI)

X , , .

, :

, ( ) ( )

. :

( )

. :

Thrs ( 150-450109/L) Thrs 150109/L.

:

,, ( )

.

() Thrs 450109/L: : ( ) -

Thrs ()

, -

()

. :

- ( )

. , ( )

() () () () ( )

C P - ( )

, :

, , , .

, , , , . , . .

, , . . ( ),

: () () :

: :

* O2 CO2.RBC contain a large quantity of carbonic anhydrase: a large amount of CO2 is transported from the tissues to the lungs under the form of bicarbonate.

*Deoxygenation of SS erythrocytes leads to intracellular hemoglobin polymerization, loss of deformability and changes in cell morphology.