11)history of facial fillers 2010 gh - a4m.com

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Age 20 Age 50 Age 49

Carruthers and Carruthers, Soft Tissue Augmentation (2005)

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Nasolabial Fold

Mental Crease

Chin (mentum)

Dorsal Nasal Area

Marionette Line

Submalar

Glabella

Jaw Line/ Pre-Jowl area

Peri-Orbital Malar

Upper

Mid

Lower

Oral Commissure

Tear Trough/ Nasojugal Groove

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Weinkle, P. The science of dermal fillers. MedscapeCME Dermatology online 2010.

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Beer K, Lupo M. Marking the right choices: attaining predictable aesthetic results with dermal fillers. J Drugs

Dermatol 2010; 9(5): 458-465.

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Dermatol 2010; 9(5): 458-465.


Dermatol 2010; 9(5): 458-465.


Dermatol 2010; 9(5): 458-465.

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Dermatol 2010; 9(5): 458-465.


Dermatol 2010; 9(5): 458-465.

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Approval Year Product Source Off/On Market 1981 Zyderm® 1 Bovine collagen Off 1983 Zyderm® 2 Bovine collagen Off 1985 Zyplast® Bovine collagen Off 2003 CosmoDerm® 1 Human collagen Off 2003 CosmoPlast® Human collagen Off 2003 Restylane Hyaluronic Acid On market 2004 Hylaform® Hyaluronic Acid Off 2004 Hylaform® Plus Hyaluronic Acid Off 2004 Captique™ Hyaluronic Acid Off 2004 Sculptra® (HIV) Poly-L-lactic acid On market 2005 CosmoDerm® 2 Human collagen Off


Approval Year Product Source Off/On Market 2006 Juvederm® Ultra/

Ultra Plus Hyaluronic acid On market

2006 Artefill® PMMA On market 2006 Radiesse® CaHA On market 2007 Perlane® Hyaluronic acid On market 2008 Prevelle® Silk HA + lidocaine On market 2008 Evolence Porcine collagen Off 2009 Hydrelle™(formerly

Elevess™) Hyaluronic acid On market

2009 Scultpra® Aesthetic Poly-L-lactic acid On market 2010 Juvederm® XC

products HA + lidocaine On market

2010 Restylane®-L HA + lidocaine On market 2010 Perlane®-L HA + lidocaine On market


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Product Correction Duration

Skin Test Mechanism of Action Injection Technique/ Effect Onset

Low density HA (Restylane Touch,

Hylaform Fine Lines)

2-3 months No Direct tissue filling Correction Immediate results

Medium density HA (Restylane)

3-9 months No Direct tissue filling Augmentation w/volume

Correction Immediate results

High density HA (Perlane,

Juvederm)

12 months No Direct tissue filling Augmentation w/volume


CosmoPlast, Zyplast

3-6 months Yes Direct tissue filling w/material injected

Overcorrection Immediate results

CosmoDerm, Zyderm I & II

6-12 months

Yes Direct tissue filling w/material injected

Overcorrection Immediate results

Werschler WP, Weinkle S. Longevity of effects of injectable products for soft tisue augmentation. J Drug

Dermatol 2005; 4(1): 20-27.


Skin Test Mechanism of Action Injection Technique Effect Onset

Radiesse 2-7 years No Stimulation of innate connective tissue using hydroxylapatite injection

that forms scaffolding


Sculptra 2-7 years No Stimulation of collagen and other connective

tissue synthesis (neocollagenesis)

Undercorrection Progressive results

over time


Dermatol 2005; 4(1): 20-27.


Skin Test Mechanism of Action Injection Technique Effect Onset

Silicone Permanent No Replacement w/volume injected as

well as encapsulation of material by ingrowth

of native connective tissue

Gradual correction but no overcorrection

Immediate results

Artecoll/Artefill Permanent Yes Encapsulation of PMMA spheres by

collagen



Dermatol 2005; 4(1): 20-27.

11)history of facial fillers 2010 gh - a4m.com

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