12b ultra low power biosensor arrays · 2017. 9. 29. · lieuwe b. leene, member, ieee, and timothy...

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This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS 1 A 0.016 mm 2 12 b SAR With 14fJ/conv. for Ultra Low Power Biosensor Arrays Lieuwe B. Leene, Member, IEEE, and Timothy G. Constandinou, Senior Member, IEEE Abstract— The instrumentation systems for implantable brain– machine interfaces represent one of the most demanding appli- cations for ultra low-power analogue-to-digital-converters (ADC) to date. To address this challenge, this paper proposes a SAR topology for very large sensor arrays that allows an exceptional reduction in silicon footprint by using a continuous time 0-2MASH topology. This configuration uses a specialized FIR window to decimate the modulator output and reject mismatch errors from the SAR quantizer, which mitigates the overhead from dynamic element matching techniques commonly used to achieve high precision. A fully differential prototype was fabricated using 0.18 μm CMOS to demonstrate 10.8 ENOB pre- cision with a 0.016 mm 2 silicon footprint. Moreover, a 14 fJ/conv figure-of-merit can be achieved, while resolving signals with the maximum input amplitude of ±1.2 Vpp sampled at 200 kS/s. The ADC topology exhibits a number of promising characteristics for both high speed and ultra low-power systems due to the reduced complexity, switching noise, sampling load, and oversampling ratio, which are critical parameters for many sensor applications. Index Terms— A/D conversion, bio-sensors arrays, oversam- pling, incremental delta-sigma, FIR decimation, low power analogue, ADC calibration. I. I NTRODUCTION T HE emergent market for wearable electronics and implantable devices for personalized health care has resulted in a growing demand for miniaturized battery powered systems that wirelessly connect a network of sensors [1]. These systems rely extensively on high precision analogue to digital conversion to leverage digital processing techniques and accommodate stringent diagnostic requirements [2]. As a result the ADC power, area, and precision can have a profound impact on a system’s overall capabilities. For this reason oversampling techniques using ADCs have already been used extensively to accommodate the niche characteristics of biomedical devices and acquire low frequency bio-signals [3]. More recent developments allow these techniques to be more applicable to large sensor arrays using an incremental analogue to digital converter (IADC) topology [4]. This is in contrast to the conventional use where a single oversampling ADC continuously converts the signal from a single sensing unit with exceptional efficiency. IADC designs are unique in Manuscript received April 19, 2017; accepted May 6, 2017. This work was supported by the Engineering and Physical Sciences Research Council under Grant EP/K015060/1 and Grant EP/M020975/1. This paper was recommended by Associate Editor A. Nagari. (Corresponding author: Lieuwe B. Leene.) The authors are with the Department of Electrical and Electronic Engi- neering, Imperial College London, London SW7 2AZ, U.K. (e-mail: [email protected]; [email protected]). Digital Object Identifier 10.1109/TCSI.2017.2703580 Fig. 1. Block level implementation of the proposed ADC array structure for sensor arrays using SAR and quantizers where a digital filter is applied to the comparator bit stream to perform decimation and mismatch correction. the sense that they periodically reset the loop filter which enables a single ADC to process multiple analogue inputs with reduced latency. This periodic reset associates a particular conversion time for each result and enables pipelined [4], two- step [5], or multi-step operation [6]. The resulting modulator can exhibit reduced mismatch sensitivity and require a smaller oversampling ratio while achieving equivalent performance to that of higher order modulators [7]. This is crucial for larger sensor arrays because reduced circuit complexity leads to more compact designs and faster signal conversion. These earlier publications realize an IADC structure that explicitly transfers the quantization residue from one quantizer to the next using a sample and hold mechanism which is not necessarily required. For instance the zoom technique used in [8] reuses the capac- itive DAC during conversion thereby reducing complexity and power consumption. The resulting system achieves exceptional precision by combining a SAR with a second order switched capacitor (SC) modulator. A common problem however is that the SAR INL/DNL errors are not shaped by the loop filter and end up limiting the overall precision unless dynamic element matching techniques (DEM) are used. This can lead to exhaustive digital overhead for DEM control and necessitate additional redundancy in the capacitive digital to analogue converter (DAC) to remove the SAR nonlinearity [9]. The system proposed by this paper is illustrated in Fig. 1 which uses a SAR and CT- together to convert the signal from four analogue inputs. This configuration is then tiled 16 times in parallel to record from 64 channels simultaneously for neural recording applications. The topology is introduced as a SAR because it emerged from introducing higher order CT- type noise shaping to the SAR by processing the residue charge left after the SAR conversion. Using SC techniques with a similar motivation also lead to the noise shaping SAR (NSSAR) topology from [10] which has been used extensively to achieve very high resolution SARs [11] 1549-8328 © 2017 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.

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  • This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination.

    IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS 1

    A 0.016 mm2 12 b ��SAR With 14 fJ/conv. forUltra Low Power Biosensor Arrays

    Lieuwe B. Leene, Member, IEEE, and Timothy G. Constandinou, Senior Member, IEEE

    Abstract— The instrumentation systems for implantable brain–machine interfaces represent one of the most demanding appli-cations for ultra low-power analogue-to-digital-converters (ADC)to date. To address this challenge, this paper proposes a��SAR topology for very large sensor arrays that allows anexceptional reduction in silicon footprint by using a continuoustime 0-2 MASH topology. This configuration uses a specializedFIR window to decimate the �� modulator output and rejectmismatch errors from the SAR quantizer, which mitigates theoverhead from dynamic element matching techniques commonlyused to achieve high precision. A fully differential prototype wasfabricated using 0.18 μm CMOS to demonstrate 10.8 ENOB pre-cision with a 0.016 mm2 silicon footprint. Moreover, a 14 fJ/convfigure-of-merit can be achieved, while resolving signals with themaximum input amplitude of ±1.2 Vpp sampled at 200 kS/s. TheADC topology exhibits a number of promising characteristics forboth high speed and ultra low-power systems due to the reducedcomplexity, switching noise, sampling load, and oversamplingratio, which are critical parameters for many sensor applications.

    Index Terms— A/D conversion, bio-sensors arrays, oversam-pling, incremental delta-sigma, FIR decimation, low poweranalogue, ADC calibration.

    I. INTRODUCTION

    THE emergent market for wearable electronics andimplantable devices for personalized health care hasresulted in a growing demand for miniaturized battery poweredsystems that wirelessly connect a network of sensors [1].These systems rely extensively on high precision analogueto digital conversion to leverage digital processing techniquesand accommodate stringent diagnostic requirements [2]. As aresult the ADC power, area, and precision can have a profoundimpact on a system’s overall capabilities. For this reasonoversampling techniques using �� ADCs have already beenused extensively to accommodate the niche characteristics ofbiomedical devices and acquire low frequency bio-signals [3].

    More recent developments allow these techniques to bemore applicable to large sensor arrays using an incrementalanalogue to digital converter (IADC) topology [4]. This is incontrast to the conventional use where a single oversamplingADC continuously converts the signal from a single sensingunit with exceptional efficiency. IADC designs are unique in

    Manuscript received April 19, 2017; accepted May 6, 2017. This work wassupported by the Engineering and Physical Sciences Research Council underGrant EP/K015060/1 and Grant EP/M020975/1. This paper was recommendedby Associate Editor A. Nagari. (Corresponding author: Lieuwe B. Leene.)

    The authors are with the Department of Electrical and Electronic Engi-neering, Imperial College London, London SW7 2AZ, U.K. (e-mail:[email protected]; [email protected]).

    Digital Object Identifier 10.1109/TCSI.2017.2703580

    Fig. 1. Block level implementation of the proposed ADC array structure forsensor arrays using SAR and �� quantizers where a digital filter is appliedto the comparator bit stream to perform decimation and mismatch correction.

    the sense that they periodically reset the loop filter whichenables a single ADC to process multiple analogue inputswith reduced latency. This periodic reset associates a particularconversion time for each result and enables pipelined [4], two-step [5], or multi-step operation [6]. The resulting modulatorcan exhibit reduced mismatch sensitivity and require a smalleroversampling ratio while achieving equivalent performance tothat of higher order modulators [7]. This is crucial for largersensor arrays because reduced circuit complexity leads to morecompact designs and faster signal conversion. These earlierpublications realize an IADC structure that explicitly transfersthe quantization residue from one quantizer to the next using asample and hold mechanism which is not necessarily required.For instance the zoom technique used in [8] reuses the capac-itive DAC during conversion thereby reducing complexity andpower consumption. The resulting system achieves exceptionalprecision by combining a SAR with a second order switchedcapacitor (SC) �� modulator. A common problem howeveris that the SAR INL/DNL errors are not shaped by the loopfilter and end up limiting the overall precision unless dynamicelement matching techniques (DEM) are used. This can leadto exhaustive digital overhead for DEM control and necessitateadditional redundancy in the capacitive digital to analogueconverter (DAC) to remove the SAR nonlinearity [9].

    The system proposed by this paper is illustrated in Fig. 1which uses a SAR and CT-�� together to convert the signalfrom four analogue inputs. This configuration is then tiled16 times in parallel to record from 64 channels simultaneouslyfor neural recording applications. The topology is introducedas a ��SAR because it emerged from introducing higherorder CT-�� type noise shaping to the SAR by processingthe residue charge left after the SAR conversion. Using SCtechniques with a similar motivation also lead to the noiseshaping SAR (NSSAR) topology from [10] which has beenused extensively to achieve very high resolution SARs [11]

    1549-8328 © 2017 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission.See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.

  • This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination.

    2 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS

    and higher order modulators with reduced active filter struc-tures [12]. In fact the fully-passive NSSAR technique canincrease the SAR precision by several bits while immune toPVT variation [13]. The distinction here is that the NSSARwill shape the quantization noise over multiple samples byintroducing 1 to 3 extra cycles per sample where as the��SAR will allow one-shot conversions but introduce consid-erably more cycles corresponding to the oversampling ratio ofthe modulator. The later is characteristic of IADC operation.Additionally the CT approach leads to an inherent reductionin size because the loop filter is not subject to extra sourcesof sampling noise typical in CS circuits. The IADC 0-2 multi-stage noise shaping (MASH) quantization scheme used bythe ��SAR can be interpreted as first resolving the sampledinput using a conventional SAR and then applying a ��feedback loop to resolve the remaining quantization residueleft on the capacitor array equivalent to the zoom technique.The resulting bit stream from the comparator output con-sists of both SAR and oversampled quantization results. Theadvantage this topology presents is that it can be configuredwithout the need for DEM or analogue dithering techniquesbecause SAR INL/DNL errors can instead be cancelled bycalibrating the FIR filter that processes this bit stream in thedigital domain. This minimises capacitive switching duringsignal conversion and reduces overall complexity. Moreoverby virtue of resolving a small SAR residue, the CT loop filtercan maximize its noise efficiency without much concern fordistortion or modulator nonlinearity.

    This paper presents an analytic design method for evaluatingwhich condition allows the zoom type IADCs to exhibit highperformance and which two-step configuration will lead tothe best efficiency or size. Preliminary efforts to realize thesystem in Fig. 1 are presented in [14] and the circuits proposedhere are improved to achieve better power efficiency as partof a larger reconfigurable neural recording system [15]. Thissystem uses an array of miniaturised ADCs that distributesthe digital processing over many parallel segments leadingto lower clock frequencies and better efficiency opposed todemanding a single high frequency ADC and digital core. Topresent the design characteristics of the ��SAR, this paper isorganized as follows. Section II introduces the principle designrelations of this ADC structure with regard to system efficiencyand size. This is followed by the proposed mismatch compen-sation method in Section III. The circuit level implementationis proposed in Section IV with design considerations for theloop filter, capacitive DAC and FIR filter. Finally measuredresults are presented in Section V which are used to drawconclusions in Section VI.

    II. ��SAR ARCHITECTURE

    The ��SAR topology closely resembles the SAR with anadditional loop filter that can switch between amplifying A(s)and integrating H (s) behaviour following the last SAR con-version. This similarity is shown in Fig. 2 which represents asingle ended equivalent of the fully differential implementationdescribed here. The input signal is sampled on the bottom plateof the capacitive array such that conventional SAR feedback

    Fig. 2. Proposed topology that interoperates SAR and oversampling quan-tizers in the same signal loop using a capacitive DAC, switched loop filter,and single bit quantizer.

    Fig. 3. Timing diagram of the sampling (SMP), SAR (S0-SN), andoversampling (��) modes of operation where C0 to CN+DC correspondto the calibrated coefficients of the FIR filter. EOC is the end-of-conversionsignal that is put low when the quantization process is finished.

    can be applied while the loop filter is initially providingwideband amplification of 10x. Once the first N bits areresolved the comparator output is connected directly to a unitelement in the capacitive array for the �� quantization phase.Simultaneously the loop filter is switched to introduce secondorder noise shaping and resolves another M bits using DCextra oversampling cycles. In theory this will result in M + Nbits of precision but in practice the SAR conversion willneed to evaluate N + 1 bits with 1 bit of redundancy. Thisredundancy implies that the residue will always be half ofthe modulator input range to prevent overloading the ��ADC [16]. If 1 cycle is used for sampling the ADC willneed to be clocked at (N + DC + 2) fsmp for a samplingfrequency fsmp with a modulator bandwidth fbw at half thisclock frequency. A typical conversion is illustrated by thetiming diagram in Fig. 3 which shows the FSM using 1 cyclefor sampling, N + 1 cycles for SAR, and DC cycles for ��modulation. Meanwhile the comparator results will infer if thecorresponding FIR coefficient provided by a shared controlleris added or subtracted from a local accumulator therebyresolving the input signal. To provide insight to the designconsiderations we will first discuss the noise requirementsneeded for achieving a N + M ADC precision. This willreveal the dominant power requirements due to the filter andcapacitive DAC and also give some indication about the sizeof each capacitor in Fig. 2 which can then be used to estimatearea. Note however that the defining characteristic of thisquantization process is that the SAR residue is bound to awell defined voltage range of ±VR/2N+1 where VR is theADC reference voltage. The reduced input range implies thatfeedback may not be needed to linearise the Gm-C loop filterused during �� conversion but it also indicates the filtercoefficients have to be carefully adjusted to achieve secondorder noise shaping.

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    LEENE AND CONSTANDINOU: 0.016 mm2 12 b ��SAR WITH 14 fJ/conv. FOR ULTRA LOW POWER BIOSENSOR ARRAYS 3

    A. Topology Optimization

    The efficient operation of low speed ADCs primarily relieson the careful consideration of various noise sources to avoiddissipating excess power. However the two modes of operationhave characteristically different requirements. Concisely statedthe �� modulator will focus on achieving a specific noisefloor because out of band noise is removed after decimationwhile the SAR operation is sensitive to integrated noise overthe entire circuit bandwidth. To illustrate the design relationsquantitatively the following discussion will reiterate on severalexpressions from well established �� theory [17]. This willallow us to determine system constraints particularly withrespect to the analogue filter that provides second order noiseshaping and in this case consumes most of the power.

    1) Filter Noise Constraints: First recall that the oversam-pling ratio for a second order modulator is dictated by Eq. 1 interms of resolving M bits. This will later be used in associationwith the expression in Eq. 2 to evaluate acceptable quantizationnoise power S2n for a N + M precision ADC.

    DC ≥ 5√

    2 π4

    15 · 2−2(M+1) (1)

    S2n =1

    12

    (VR

    2N+M+1

    )2(2)

    Now in order to capture the subjective performance ofthe circuit level implementation and its impact, this analysisuses the Noise Efficiency Factor (NEF). The expression forNEF in Eq. 3 normalizes the input referred noise e2in of aparticular implementation to that of a bipolar transistor witha biasing current equivalent to that used by the filter I f ilt .As a result we can abstractly consider noise-power relationswithout considering a specific filter topology that will exhibitsome particular NEF.

    N E F2def= 2I f ilt e

    2in

    πUT 4kT fbw(3)

    In fact by combining this with the ADC noise requirement inEq. 2, I f ilt can be predicted as a function of circuit topologyand its equivalent NEF. This is detailed in Eq. 4 under thecondition that e2in = S2n where the relevant circuit noisebandwidth is reduced fbw/DC due to oversampling.

    I f ilt = πUT 24kT fbwDC

    (2N+M+1 N E F

    VR

    )2(4)

    Similarly I f ilt can be evaluated for just the SAR operation

    as a special case: IS ARdef= I f ilt (DC = 1, M = 0). In the

    case that IS AR is larger than the estimate in Eq. 4 we shouldadopt that value instead. This result is mainly relevant for SARconverters where an analogue amplifier is used to precede thecomparator and thereby dominating the noise requirements[18]. Here it will also be used to indicate the preliminaryperformance with respect to N & M with a fixed clockspeed and the associated conversion time of N + DC + 2cycles. The resulting conversion efficiency is proportional to2N+M /PA(N + DC + 2) as conversion per Watt where totalanalogue power is estimated as PA ≈ VR I f ilt . In this case the

    Fig. 4. Power efficiency as 2N+M /PA(N + DC +2) in terms of conversionsper Watt where N+M is the target precision of the analogue filter for differentvalues of N & M normalised by the best case where M = 8 & N = 1.

    filter supply voltage is simply equal to the reference voltage.Normalization allows the relative efficiency to be visualizedin Fig. 4 which provides some evidence that the filter alonetends to be more efficient as M becomes larger than N .However N can not be arbitrarily small if the residue needto be kept in the linear range of the modulator. This impliesa direct relationship between the ADC reference voltage andthe minimum SAR resolution. The details of this requirementis strongly dependent on the full ADC precision and itssensitivity towards transistor nonlinearity. However as a priorithe minimum SAR resolution N can be approximated byconsidering that the linear input range for a sub-thresholddifferential input pair is related to the thermal voltage ±UT[19] which suggests that N ≥ log2(VR/UT ) to keep theresidue inside the linear range.

    2) Estimating System Power: The previous result is rela-tively optimistic in the sense that it does not consider thedecimation filter or DAC power dissipation. To warrant anaccurate estimation of the ADC’s efficiency and resourcerequirements the Digital PD , and capacitive switching PClosses should also be estimated.

    PC = CU fsmp V 2R(

    DC/2 +N∑

    i=1(2i − 1)2N−2i−2

    )(5)

    Eq. 5 includes the SAR energy dissipation in terms ofthe capacitive switching using the analysis from [20]. TheVcm based switching method employed here retains a stablecommon mode on VD AC with good conversion efficiency.This will help to preserve the linearity of the modulator.Variation in common mode voltage changes the offset ofthe loop filter as well as the impact of top plate parasitics[20]. Both will introduce nonlinearity that is convoluted bythe SAR quantization process and can be challenging tocompensate accurately. PC is evaluated for N + 1 SARcycles where the unit capacitor CU size introduces somedegree of freedom. Strictly the total capacitance is boundedsuch that the kT/C noise is smaller than noise requirementof Eq. 2. For instance we could let the sampling noisecontribute half the allowable noise power which leads to aminimum capacitance according to Eq. 6 given a 2N+1 unitbinary DAC.

    CU = 12 kTV 2R

    2N+2M+1 (6)

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    4 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS

    This unit element should be noticeably larger than whatmay be expected from SAR configurations due to the smallnumber of elements in the capacitor array resulting in reducedmatching and interconnect complexity. Generally such aconfiguration will favour high density vertical metal-insulator-metal (MIM) capacitors that have large minimum size require-ments and can be placed over active circuitry to reduce siliconfootprint. In fact by using a split capacitor configuration thesize of CU can be even larger with less elements in the arrayfor the same sampling capacitance leading to very efficientutilization of MIM capacitor area [21]. It may still be thecase that CU is smaller than the minimum capacitance Cminfor intermediate precision of 6-10 bits. In such a case thismodel will simply adopt Cmin . This will also apply to theload capacitance CL1 when it is calculated with respect tothe modulator bandwidth as fbw = gm1/CL1. However thisshould carefully consider the reduced input swing of VR/2N+1which means the transconductance for a conventional fully-differential input in sub-threshold operation would be gm1 =VR I f ilt /(ηUT 2N ) where η is the transistor slope factor.

    In order to estimate the digital losses this model extrapolatesthe energy dissipation per clock cycle extracted from a 1 bitaccumulator taken as Ereg . The associated register depthRD = N + M + log2(DC)bits is derived by consideringthe accumulated rounding errors from DC additions duringFIR decimation. This leads to Eq. 7 which is expected to beinsignificant at higher resolutions because decimation filter hasreduced requirements when compared to the full precision ofthe integrator.

    PD = RD Ereg fsmp (DC + N + 2)︸ ︷︷ ︸Cycles/Sample

    (7)

    3) FOM Dependence: The above relations should providea good indication for the power requirements even thoughsome system components such as the comparator and auxiliarycircuits have been ignored. The Walden FO MW and SchreierFO MS are presented in Eq. 8 & 9. These performance metricsare plotted in Fig. 5 by assuming typical values from the0.18 μm CMOS process. VR is adjusted to 0.6/1.2/2.4 Vwhich keeps the linear input range of the �� modulatorconsistent while resolving different SAR resolutions for faircomparison. Other constants are assumed as follows; η = 1.2,N E F = 1.4, Ereg = 1 fJ, Cmin = 10 fF, fsmp = 105 Hz,fbw = 105 (N + DC + 2)/2 Hz. The general trend presentedhere is that the topology operates at maximal performancewhen the most of the power is dissipated by the oversamplingloop and the lowest energy per conversion is dissipated whenthe capacitive switching and modulator power become com-parable. It is not surprising that reducing the supply voltagemakes it more difficult to achieve a good FOM because theabsolute noise performance becomes more difficult to achieve.For reference a conventional �� modulator [22] is designedwith the same target specifications and using the same analysismethod to configure the OPAMP integrators and resistiveinput network. Such a configuration achieves 167 dB FO MSirrespective of target resolution when we consider just the filterpower dissipation. In fact this figure is commonly achievedby state of the art [8]. This highlights how the ��SAR

    Fig. 5. Estimation on the expected F O MS and F O MW for a resolutionand varying SAR precision. The red star and blue circle indicate the targetand measured performance respectively. The blue stars correspond to F O MWachieved by other works.

    configuration can theoretically achieve more than 2X betterperformance for resolutions above 12 bits even when operatingat lower supply voltages.

    FO MW = PC + PD + PAfsmp 2N+M

    (8)

    FO MS = 6.02 (N + M) + 10 log10(

    fsmp/2

    PC + PD + PA)

    (9)

    E A =(

    2 CL1 + CU 2N+2)

    /Cdens (10)

    The required area for this configuration is estimatedby Eq. 10 which uses the MIM capacitor density Cdensof 2fF/μm2. As shown in Fig. 6 high resolution configurationswill tend towards noise limited requirements that are closelyrelated to the integration and sampling capacitors. Lowerresolutions are largely dependent on technology and how theSAR DAC is configured to address mismatch. Fig. 7 showsthe impact of M on overall ADC efficiency in combinationwith the area requirement. This is characterised using thedensity of performance DO P = FO MS − 10 log10(E A)which peaks for an ENOB of 11.4 bits with M being 5.8 bits.The overall quantitative results show exceptional figures ofmerit with highly compact configurations for 10-16 bit designsfrom first principles. The design described above only focuseson achieving an optimal noise performance because it dom-inates the low frequency FOM metrics. Naturally a numberof extra considerations need to be made for achieving thedesired ENOB. Finding the requirements for open loop gain,parasitics, nonlinearity, and digital filtering is done by usingnumerical optimization on simplified models guided by ana-lytic results from prior work [22], [24]. However we canobserve some agreement with this simplified model and theperformance achieved in other works.

    III. FOREGROUND CALIBRATION FOR THE ��SAR

    The foregoing analysis suggests that the resources dedicatedto SAR operation should be kept small in order to achievethe peak performance of the oversampling modulator. Asa result the DAC linearity may be much worse than the

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    LEENE AND CONSTANDINOU: 0.016 mm2 12 b ��SAR WITH 14 fJ/conv. FOR ULTRA LOW POWER BIOSENSOR ARRAYS 5

    Fig. 6. Estimated area requirements with respect to ADC resolution forvarious SAR resolutions. The red star and blue circle indicate the target andmeasured performance respectively. The blue stars correspond to area achievedby other works.

    Fig. 7. The estimated DOP with respect to the target ENOB and the�� modulator resolution. This normalised by the best configuration whereM = 5.8 & E N O B = 10.9 (i.e. N = 5.1). VR is assumed to be 1.2 V andthe red star indicates the target performance for this implementation.

    target precision. Ideally before instrumentation the systemshould perform a calibration procedure that determines theactual capacitor weights WD AC and recovers any lost accuracydue to mismatch in the digital domain [25], [26]. Digitalcalibration techniques are extensively used for SAR convertersbecause they enable more aggressive capacitor sizing withoutintroducing extra analogue complexity that does not benefitfrom technology scaling [27]. A simplified model of thequantization process is shown in Fig. 8 where the SAR resultis fed back according to the 7 capacitor weights WD AC toproduce a residue that is oversampled by the modulator anddecimated by the FIR filter. The mismatch errors arise whenthe coefficients WS AR do not correctly calculate the exactcharge offset by the capacitors (i.e. WD AC �= WS AR). Thestructural advantage here is that all mismatch induced errorsare accurately evaluated by the oversampling loop which canoperate with extra noise shaping during calibration withoutneeding a more precise reference ADC. First note that theDNL errors due to DAC mismatch are only observed uponchanges in the SAR codes. Secondly the single bit ��modulator can present significantly better linearity withoutcalibration if SAR codes remain unchanged. Moreover ifthe weights are correctly estimated we should expect nodiscontinuities in the DNL characteristic for slowly varyinginputs. The proposed calibration method takes advantage ofthese observations by correlating the first order difference

    Fig. 8. Simplified model of the ADC structure quantization processillustrating how capacitor weight estimation WS AR and actual capacitorweights WD AC propagate to the output.

    of the ADC output and the SAR codes to find the correctcoefficients for WS AR . In addition by using a triangular testsignal to perform calibration this procedure does not need fullprecision multipliers. This is because the triangular waveformdistributes the occurrences of each SAR code evenly when atleast one sample is taken per SAR code. Therefore the numberof toggles on each SAR bit is exactly distributed as powersof two. Now if each SAR coefficient is adjusted when therespective SAR bit toggles then the rate of adjustment foreach capacitor weight will be uniform if the adjustments areproportionally scaled by powers of two.

    WS AR[n + 1] = WS AR[n] + α sign( ˙Qout [n] ˙QS AR[n])︸ ︷︷ ︸ternary result (+1/0/-1)

    (11)

    Eq. 11 introduces the proposed method for iteratively updat-ing WS AR for the nth sample using α as fixed adjustmentfactor. ˙Qout is the first order difference of the quantizedoutput which is a function of the SAR QS AR and modulatorQ�� outputs. The exact relation is expressed in Eq. 12.No multiplication is required here because whether a SAR bithas toggled is strictly Boolean and represented by ˙QS AR[n].This leads to a ternary result with respect to the adjustmentrule for incrementing or decrementing the estimated weightsthat can be implemented using 7 up/down counters of varyingdepth. In this case the MSB counter has a logical depthof 16 bits while the LSB uses 22 bits.

    Qout [n] = QS AR[n] · WS AR[n] + 2−N Q�� · WF I R (12)If we presume our �� converter has ideal performance then

    2−N Q�� · WF I R = VI N [n] − WD AC [n] which leads to ˙Qoutas:

    ˙Qout [n] = ˙VI N [n] + ˙WS AR[n] − ˙WD AC [n] (13)Eq. 13 reveals that during calibration the output will consist

    of two components. The first is due to the input as the ramp’srate of change ˙VI N that is either increasing or decreasing.The second term results from an incorrect weight estimate onwhichever SAR bit changed. In fact depending on the signof this error we know if the estimated weight needs to belarger or smaller. In essence Eq. 11 uniformly averages overall DNL errors to approach the correct weights.

    IV. CIRCUIT IMPLEMENTATION

    Using the foregoing results, the presented implementationtargets a 12 bit resolution using N = 6 & M = 6 which should

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    6 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS

    Fig. 9. Schematic level implementation of the switched loop filter using noise efficient complementary transconductors and a current mode summation circuit.

    lie just on the inflection point of estimated area requirementcurve. In particular we will present the configuration for afully differential sensor array using analogue and digital sup-plies at 1.2 V and a commercially available 6-Metal 0.18 μmCMOS technology (AMS/IBM C18A6/7SF).

    A. Loop Filter

    The loop filter topology used here is a second order feedforward architecture that is used extensively in CT modulatorsdue to its reduced complexity and low distortion [28], [29].This particular structure reduces the number of summationnodes and digital feedback elements to minimise power con-sumption. The signal and noise transfer functions due theloop filter H (s) = 2N (s2 + 2 ωbw s)/ω2bw and the feedbackfactor f ≈ 2−N are summarised in Eq. 14 & 15 whereωbw is the filter bandwidth in radians. The feedback f isdetermined by evaluating the capacitive coupling from C��onto VD AC . Since f is quite small there is an apparent gain inthe STF but not in the NTF. This gain is provided by increasingthe bandwidth of the first stage by 2N which substantiallydiminishes the input referred noise from the second integratorand comparator. Then using the requirements from Sec. II-A.1will allow the capacitors to be specified for this implementa-tion as fsmp (N + DC + 2)/2 = 4VR IB1/(η UT 2N CL1) =2VR IB2/(η UT CL2).

    NT F(s) = s2

    s2 + 2 ωbw s + ω2bw(14)

    ST F(s) = 2N 2 ωbw s + ω2bw

    s2 + 2 ωbw s + ω2bw(15)

    The transistor level implementation is shown in Fig. 9 wherethe switches S�� allow the filter to change its operation. Thefirst stage uses a fully differential complementary or inverter-based transconductor that can tolerate small variations ininput common mode fluctuation by ±100 mV and this specificconfiguration exhibits an N E F ≈ 1.6. The sizing of thiscomplementary pair requires some attention regarding thecapacitive loading on VD AC due to the gate to drain capaci-tance of the transistors. In fact Cu needs to be considerablylarger than this parasitic such that the open loop gain of thefirst integrator is not reduced and thereby diminishing filterperformance. The circuit is segmented into three sections;two analogue integrators and one summation stage. The first

    integrator will switch between resistive and capacitive loads.This stage will have the most demanding bandwidth require-ment when providing pre-amplification during SAR quanti-zation. Both integration capacitors are reset outside of the�� phase and the last two stages should achieve -40 dBHD3 for a ±100 mV input signal which is derived fromsimulations [24]. The common mode feedback on the twointegrators uses linear mode devices that reference VD D/2.These transistors can be quite large and introduce considerableparasitics because of the large current dissipated in the firststage. To avoid a reduction in bandwidth, a sub-set of thesegates are connected to the loading capacitor CL1 that isswitched out during SAR conversion which retains the steadystate common mode voltage. The 1-bit quantization is realizedusing a dynamic latch where offset associated concerns shouldfollow conventional wisdom for accurate SAR conversion. Thediode connected load in the summing stage places the inputcommon mode of the comparator close to VD D. This improvesboth the bandwidth and noise performance of the latch [30].

    B. Capacitive DAC

    A 7-bit fully differential binary weighted capacitive DACis used to perform the SAR quantization. The single endedstructure is shown in Fig. 10. The voltage scaling on thelast conversion cycle reduces the number of capacitors neededand takes advantage of the reduced reference sensitivity forthe last SAR conversion. Because calibration is performedwith respect to C�� that references VR the mismatch in thelast SAR coefficient will also accommodate the mismatchin voltage reference. The array is realized by precision topmetal-on-metal capacitor devices which utilize M5-M6. A M4VC M shield is introduced to isolate this array from activeanalogue and digital circuitry placed below. While bottomplate sampling diminishes the effect of parasitics on VD AC ,the split capacitor needs tuning according to the extractedparasitics on the LSB section particularly with respect to theshielding layer. The unit capacitor is 71 fF with 6×6 μm2dimensions yielding 0.2% deviation of capacitor mismatch fora 3σ confidence interval. This should allow a precision of 9ENOB without calibration [31] and will utilise all the top metalarea needed for the sub-blocks placed below.

    During sampling each input will be loaded by a totalof 768 fF for an equivalent 52 μVrms sampling noise. Thisshould indicate that the upper bound of maximum signal to

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    LEENE AND CONSTANDINOU: 0.016 mm2 12 b ��SAR WITH 14 fJ/conv. FOR ULTRA LOW POWER BIOSENSOR ARRAYS 7

    Fig. 10. Single ended equivalent of the 7-bit split-capacitive SAR DAC usingvoltage scaling on the smallest weight.

    noise and distortion ratio (SNDR) for this DAC is 78 dB. Alsonote that the INL characteristic of the SAR and comparatornoise will inevitably lead to additional sources of quantizationerror which implies the �� input range will correspond-ingly increase from its expected value. Moreover resolvinga sampled input with a �� modulator can lead to increaseddistortion due to idle tones. This is why the modulator shouldbe designed such that signals that are −3 dB of the maximum�� input range can still be adequately resolved. Fortunatelycomparing single bit modulators reveals second order feed-forward structures are substantially more capable of processingsignals close to the full range input due to improved stabilitydynamics [16]. This means the DAC mismatch requirementsare less stringent and will not need a sub-binary weight-ing or additional calibration capacitors to minimize the sourcesof excess residue. The simpler binary weighted structure willallow good baseline matching for the unit capacitors withthe minimum number of elements in the DAC. Moreoverintroducing the split capacitor in addition to the Vcm switchingmethod dramatically reduces the total switching energy tothe extent that it is dominated by the oversampling phase.Particularly when multiple data converters are operated inparallel the excessive capacitive switching raises a concern forhigh frequency supply noise of the reference voltage that isoutside the LDO bandwidth. The anti-aliasing provided by theloop filter will partly reject this component as a result of optingfor a CT implementation. The �� feedback will dissipate atmost 77 fC every cycle which needs to be partly absorbedby decoupling capacitors local to the ADC. High densityMOS capacitors are therefore introduced to load the referencevoltage by 20 pF per ADC. The reduced switching noiseshould represent a clear advantage over switched capacitormodulators. An improvement over the conventional SAR mayonly be expected when calibration overhead is unavoidablebecause the sampling noise constraint makes energy dissipa-tion in SAR switching mostly indifferent to its resolution.

    C. FIR Filtering

    Decimation of the �� bit stream of incremental topologiesfinds the application of FIR filters particularly suitable. Thisis in part because resetting the integrators for each sample anddiscards residual components from the previous conversionand the corresponding group delay requirement can limit theIIR filter design. Moreover sharing FIR filter coefficients withmultiple ADCs reduces the hardware requirements to a sharedlookup table with individual accumulators for each modulator.Using an OS R of 24 implies N + DC + 1 = 31 additions

    Fig. 11. Overall noise shaping profile of the modulator and FIR in cascadefor K = 2 and K = 1.33.

    are needed per sample where a second order CIC filter wouldneed at least N + 2DC + 3 = 57 additions per sample fora full evaluation and four times the number of registers [32].From Sec. II-A we know that the register depth RD should be16 bits while the FIR coefficient precision needs to be 8 bits.The application of a symmetric FIR window also assists with anumber of circuit considerations for rejecting noisy aggressorsnear fbw [8]. Supply noise is a typical culprit but it maybe less obvious that the FIR also reduces the sensitivity dueto the second integrator’s offset when the quantization modeswitched. Hanning or raised cosine FIR windows are knownto provide exceptional aliasing particularly when applied tosample limited �� decimation [33]. Using a general familyof raised cosine windows [34] a configuration is proposed herethat matches the noise shaping of the loop filter order (L) withthat of the FIR side-lobe roll-off by defining its coefficientsas:

    F I R[n] = cosK(

    π n

    OS R + 1 −π

    2

    )(16)

    The factor K in Eq. 16 determines the spectral charac-teristics of the filter similar to that of the kaiser windows.The rapid side-lobe roll-off is related to K as 30K dB/Decwith the first zero location at π(1 + K/2) fsmp . Because thequantization noise is shaped in relation to L at 20L dB/Dec [5],K can be defined as K = 2/3 L. This leads to a near uniformquantization noise profile with a reduced transition band frombetter pole placement. The K -factor dependent frequencycharacteristics are shown in Fig. 11 for an OS R = 16 appliedto the output of a second order modulator. Note that whenK = 2 the FIR is equivalent to that of a Hanning window.The overall system transfer function Sys(z) can be analysedin the z-domain using a bilinear transform of the loop filterH (s) and convolving it with that of the FIR response. To seehow well decimation is achieved we compare the decimationperformance to that of an ideal filter.

    S2Q =2π2L

    3(2L + 1)(OS R)2L+1 (17)Eq. 17 introduces the expected in-band quantization noise

    power S2Q from analytic relations [35] which assume an idealbrick-wall filter with a cut off frequency at fsmp/2 that is not

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    8 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS

    Fig. 12. Quantization noise suppression based on numerical simulations andEq. 17 and the respective precision loss for varying OS R.

    Fig. 13. Microphotograph of the 64 channel neural recording system showingtwo 32 channel macros used in parallel with integrated power managementand digital processing.

    limited in any way. Similarly integrating over the resultingpower densities in Sys(z) will indicate the expected quan-tization noise from the proposed configuration. Comparingthese two results will indicate how effectively the quantizationnoise is rejected by the FIR filter. The noise excess is shownin Fig. 12 as a function of OSR and filter order. This showsthat using the proposed window results in loss smaller than0.5 bits. Also notice that we do not pay special attention tohow the �� quantization noise folds onto the signal band.After the signal is convolved by the SAR quantization processthe residue no longer shares the same structure as the inputsignal and therefore better in band decimation performancewill not lead to better in band SNR.

    V. MEASURED RESULTS

    A chip micrograph is shown in Fig. 13 depicting the64 channel instrumentation system with die size of 6.2 mm2.This configuration uses two macros each of which integrateseight ADCs together with the DSP in a tiled fashion to post-process the recordings from 32 instrumentation amplifiers.In fact the architecture may be scaled to accommodate morechannels by virtue of the pipelined architecture that distributesthe processing capacity. The measured results presented hereare taken from an isolated test structure that allows detailed

    Fig. 14. Fabricated ��SAR prototype showing a) an isolated test ADCstructure used for characterization b) a close up micrograph showing thecapacitive DAC and top metal c) the ADC layout with annotated sub-blocks. The SAR capacitors are highlighted in blue and numbered in term ofwhich SAR bit they represent. The analogue MOS and MIM capacitors arehighlighted in red showing the filter capacitors L1 & L2 and the decouplingcapacitors.

    Fig. 15. Measured INL of the ADC before and after calibration with 2.4 Vdifferential amplitude.

    characterization without overhead from the whole system.The physical implementation of the ��SAR sub-block isshown in Fig. 14 which is 96μm× 164μm in size. Becausethe DSP is assisted by a specialized execution unit thatalso performs neural signal decomposition only the digitalaccumulator is included in this figure. The active componentsinside the modulator contribute to a small portion to the overallsystem. Instead the most demanding layout consideration iswith regard to the switches driving the capacitive DAC. Eventhough the capacitance is not too large, the switch resistancein �� mode can introduce a pole leading to excess loop delaythat could result in performance degradation [36].

    Initial ADC characterization used a low-frequency 180 Hztone at half to the full input range where the comparatorbit stream was directly acquired off-chip for post-processing.This allowed the proposed calibration mechanism to be com-pared with more robust methods. In fact when using moreelaborate numerical optimization methods to adjust WS AR theTHD only showed 2 dB improvement although convergence istypically much faster. Both testing and calibration waveformswere generated off-chip using an Agilent 33120a with addi-tional bandpass filtering. The measured INL characteristics

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    LEENE AND CONSTANDINOU: 0.016 mm2 12 b ��SAR WITH 14 fJ/conv. FOR ULTRA LOW POWER BIOSENSOR ARRAYS 9

    Fig. 16. Convergence of DNL rms and peak to peak values during calibrationsubject to a 90 Hz triangular waveform.

    Fig. 17. Measured ADC performance showing the spectral characteristics ofa) SAR residue at the output of the �� and b) the full precision output whichhas a SNDR of 66.8 dB. This recording was taken using a 2.35 Vpp 95 kHzinput tone sampled at 200 kHz.

    are shown in Fig. 15. The calibration method decreases theSAR nonlinearity by a factor of 10. As shown in Fig. 16the main drawback of this method is that in order to rejectnoisy perturbations the α rate must be small amounting to slowconvergence on the order of 106 quantization cycles or around10 seconds. The DAC used for generating the ramp signal willneed to be more accurate than the ADC precision to allowcorrect calibration. On the other hand instead of using a morepowerful centralized DSP unit to perform tuning, this systemallows all channels to calibrate simultaneously resulting in aspeed up for multichannel systems that can share a single highresolution DAC. The discontinuities visible in this trend resultfrom the fitting method used to calculate DNL as a functionof time which is not very consistent.

    Fig. 17 shows the spectral characteristics of the ADCafter the capacitor weights have been estimated with 16 bitprecision together with the SAR residue that can be obtainedby only taking the decimated modulator output. This illustratesthat SAR residue has its spectral power distributed over theentire bandwidth at multiple tones. This wideband quantiza-tion ‘noise’ will in effect present dithering on modulator’snonlinearity before appearing at the output. Fig. 18 showsthe signal resolved by the modulator as a function of time.Interestingly the polarity in residue will directly correspondto the polarity of the sampled input signal because swapping

    Fig. 18. FIR output over time due to a 1.2 Vpp 180 Hz input tone showingthe quantized residue after SAR conversion.

    Fig. 19. Measured quantization noise spectrum of the second order ��modulator that is clocked at 7 MHz averaged over 103 conversions with anOSR of 24.

    Fig. 20. Measured F O MS dependency for varying OSRs but keeping a7 MHz system clock frequency for a 10 k H z 2.4 Vpp input tone.

    the reference voltage on the capacitive DAC will imply asuccessive approximation while maintaining correspondinglypositive or negative residues. Then by performing a Fouriertransform on the measured modulator output for each conver-sion separately we can evaluate the noise shaping characteristicof the loop filter. This result is shown in Fig. 19 which followsclosely to the expected second order noise shaping.

    In Table I the performance is summarized and state-of-the-art noise shaping ADC structures are compared. This workachieves exceptional compactness for the 12 bit target resolu-tion particularly in relation to the conversion efficiency [37].The measured power dissipation is about 5 μW of whichsimulations indicate 40% is dissipated in the loop filter and23% in capacitive switching. Note that power dissipation fromthe look up table is not included in this figure. Fig. 20 presentsthe measured SNDR and FO MW for varying oversamplingratios. During calibration the OSR was doubled to gain 3 dBin precision while the typical operation uses an OS R of 24.The total conversion uses an additional 11 cycles for SARand sampling phases to give the resulting 200 kS/s speed for a7 MHz system clock. We also show the measured SNDR forvarying input frequencies in Fig. 21. This shows that maximum

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    10 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS–I: REGULAR PAPERS

    TABLE I

    COMPARISON OF STATE-OF-THE-ART ADC SPECIFICATIONS

    Fig. 21. Measured SNDR dependency for varying input frequency for a2.35 Vpp input tone.

    precision is maintained for signals below 20 kHz but alsoshows some degradation at frequencies near the maximuminput bandwidth. The main experimental difficulty resultingfrom the proposed configuration is that the filter characteristicsare closely tied to the reference voltage in a practical setting.On occasion it is useful to give additional voltage overheadfor aggressive digital and analogue systems to accommodateprocess voltage and temperature variance. However in thiscase the biasing circuit will need extra tuning parametersto keep the modulator’s linearity consistent while adjustingthe reference voltage. Multi channel systems can generallyaccommodate complex tuning for all ADCs to eliminatewafer/process level variations without substantial overheadsince this functionality is already needed by instrumentationcircuits to perform precise filtering. The power managementblock in Fig. 13 provides 12 bit digital trimming on the ADCreference voltages and bias currents such that most of the off-set can be accommodated although this is performed externallyon the test structure.

    VI. CONCLUSION

    A novel 12-bit analogue-to-digital data converter has beenproposed that uses SAR & �� quantization schemes torealize a compact and ultra low power data converter for a64 channel neural sensor system. Using an efficient Gm-Cfilter, compact 7 bit binary DAC, and optimized FIR deci-mation this work aims to eliminate the circuit complexityfrom DEM and increase power efficiency which is highlydesirable for biomedical sensors. A prototype fabricated in

    0.18 μm CMOS demonstrates 10.8 ENOB precision at thenyquist frequency with a state-of-the-art 0.016 mm2 siliconfootprint and is capable of resolving full scale signals at200 kS/s. The proposed techniques are appropriate for a varietyof sampling frequencies making this configuration applicableto numerous other applications that require aggressive ADCminiaturization. In addition a calibration technique suitablefor large sensor arrays is presented that takes advantage ofthe two step quantization scheme to calibrate multiple ADCssimultaneously.

    ACKNOWLEDGMENT

    The authors would like to thank Nicolas Moser and thereviewers for helpful comments and assistance with improvingthis manuscript.

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    Lieuwe B. Leene (S’13–M’16) received the B.Eng.degree from The Hong Kong University of Sci-ence and Technology in 2011 and the M.Sc. andPh.D. degrees from the Imperial College Londonin 2012 and 2016, respectively, all in electronicengineering. He is currently a Research Associatewith the Center for Bio-inspired Technology, Depart-ment of Electrical and Electronic Engineering, Impe-rial College London. His research interests includelow noise instrumentation systems, brain–machineinterfaces, data converters, and mixed signal

    circuits for biomedical applications.

    Timothy G. Constandinou (A’98–M’01–SM10)received the B.Eng. and Ph.D. degrees in elec-tronic engineering from the Imperial College Londonin 2001 and 2005, respectively. He is currentlya Reader in neural microsystems with the Cir-cuits and Systems Group, Department of Electri-cal and Electronic Engineering, Imperial CollegeLondon, and a Deputy Director of the Centerfor Bio-inspired Technology. His research inter-ests include neural microsystems, neural prosthetics,brain machine interfaces, implantable devices, and

    low-power microelectronics. He is a fellow of the IET, a Chartered Engineerand a member of the IoP. He serves on several committees/panels with theIEEE, regularly contributing to conference organization, technical activities,and governance. He was the Technical Program Co-Chair of the 2010 and2011 IEEE BioCAS conferences, the General Chair of the 2016 BrainCASworkshop, the Special Session Co-Chair of the 2017 IEEE ISCAS conference,and the Demonstrations Co-Chair of the 2017 BioCAS conference. He iscurrently the chair-elect of the IEEE Sensory Systems Technical Committee,a member of the IEEE BRAIN Initiative Steering Committee, member of theIEEE BioCAS Technical Committee, and serves on the IEEE Circuits andSystems Society Board of Governors for the term 2017–2019. He is also anAssociate Editor of the IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITSAND SYSTEMS (TBioCAS).