13-4 Applications of genetic engineering

Goal: modify cells to correct a defect or produce a desired product.

13-4 applications of genetic engineering

• Transgenic engineering: • Transgenic bacterium• Transgenic animals: mice, transgenic

livestock• Transgenic plants: with natural

insecticide, producing human antibodies

• Eg: transgenic plants produce natural pesticide to resist to pest

Transgenic plants

• Genetically modified (GM) food

Engineered Plants（转基因植物）

• Cotton plants that display resistance to herbicide 

  

Engineered Plants（转基因植物）

• Tobacco plants that produce human proteins

Engineered Plants（转基因植物）

• Mustard plant (芥菜 ) cells that produce biodegradable plastic

Engineered Mammals（转基因动物）

Hi~~~ I’m ANDi, the world’s first

genetically modified non-

human primate

A monkey named ANDi, for "inserted DNA", in a picture released in January 2001. ANDi was born in October 2000 at the Oregon Health Science University after receiving an extra bit of genetic material to become the world's first genetically modified non-human primate

Cloning Dolly• Sheep A: donate body cell nucleus • Sheep B: donate an egg cell without nucleus• Sheep C: surrogate mother

A CB Dolly

Who’s its mother?

Cloning Dolly

1997 - A sheep cloned from an adult cell

• Nucleus from body cell was inserted into an empty egg

• Embryo implanted into surrogate mother

• Sheep is genetic replica of animal from which body cell was taken

Ethical Issues

• Who decides what should be “corrected”

through genetic engineering?

• Should animals be modified to provide

organs for human transplants?

• Should humans be cloned?