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14th ANNUAL

NIH GRADUATE STUDENT RESEARCH SYMPOSIUMFEBRUARY 22, 2018NIH NATCHER CONFERENCE CENTER, BETHESDA, MARYLAND

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14th ANNUAL

NIH GRADUATE STUDENT RESEARCH SYMPOSIUM FACES OF TOMORROW'S SCIENCE

2018

FOREWORD AND ACKNOWLEDGEMENTS .................. 2

PROGRAM OF EVENTS ................................................ 4

NIH GRADUATE PARTNERSHIPS PROGRAM GRADUATION AWARD RECIPIENTS ............................ 5

KEYNOTE SPEAKER .................................................... 8

STUDENT SPEAKERS .................................................. 9

OUTSTANDING MENTOR AWARD RECIPIENTS ..........11

STUDENTS ..................................................................13

POSTERS ....................................................................17

Graduate Partnerships Program Office of Intramural Training & EducationOffice of Intramural ResearchNational Institutes of HealthU.S. Department of Health & Human Services

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FOREWORD

Every year, the National Institutes of Health (NIH) Graduate Student Research Symposium showcases the

breadth of scientific research and the achievements of the graduate student community at the NIH. The

symposium is the largest graduate student event of the year, an event in which graduate students can come

together to share their research, appreciate the work of their colleagues, and celebrate the successes of the

graduate student community.

In its fourteenth year, this annual symposium provides an opportunity to acknowledge the scientific

accomplishments of the hundreds of graduate students working on their dissertation research at the NIH. This

symposium highlights the spectrum of scientific research conducted by graduate students at the NIH, who

represent numerous universities across the world and span nearly all institutes and centers within the NIH. The

NIH Graduate Research Symposium recognizes the diversity of research specialties supported by the NIH and

exhibits the scientists of tomorrow, from those developing new research proposals to those preparing to defend

years of dissertation research.

This symposium will provide the graduate student community with the chance to hear about the scientific work

of their peers in several formats. In the morning, we will be holding our 2nd annual elevator pitch competition in

which current graduate students will be judged on their ability to explain their science to a general audience in

two minutes or less.

Following the opening remarks by the Director of the Office of Intramural Training and Education (OITE),

Dr. Sharon Milgram, we are honored to welcome our keynote speaker Dr. Eric Betzig. Dr. Betzig has led a life

dedicated to curiosity and a drive to understand and visualize the processes in living cells. After graduating from

Cornell University in 1988, he began his career at AT&T Bell Labs, where he studied near-field microscopy. Here,

he conducted pioneering research that vaulted him to the forefront of the field during a time of exciting increases

in resolution. In 2005, he reconnected with a former coworker from Bell Labs, Dr. Harald Hess, and together

they started working from their homes. Through that endeavor, they developed the first prototype of the super-

resolution localization microscope and were subsequently awarded the 2014 Nobel Prize in Chemistry. NIH

graduate students will find both his nontraditional career path and his dedication to scientific progress inspiring.

In the afternoon, students will present their research through scientific posters judged by NIH postdoctoral

fellows and staff scientists. Winners of the poster competition will be awarded the prestigious NIH Graduate

Student Research Award generously funded by the OITE. The poster sessions will be followed by four oral

presentations by current students, who will present scientific talks chosen based on scientific merit and diversity.

NIH GRADUATE STUDENT RESEARCH SYMPOSIUM 2018

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After the student oral presentations, we will present the awards for outstanding research mentors. Our success

as graduate students would not be the same without the guidance of high-quality research mentors, who have

supported us in innumerable ways, from providing networking opportunities to career development advice. We

are grateful for the influential mentorship provided at the NIH to help us become independent scientists and forge

relationships extending beyond graduate school. Four outstanding mentors nominated by their students will be

honored for their leadership, support, and dedication to their graduate students. The day will conclude with a

graduate ceremony to recognize those students who have defended their dissertations within the past year.

Dr. Sharon Milgram will present the recent graduates with a certificate in honor of their accomplishments.

We are thankful for the opportunity to share our research with the entire NIH community at the 14th Annual NIH

Graduate Student Research Symposium. We thank all of the graduate students who have participated in this event

and those who have provided us with continuous support in our scientific careers. We hope this event establishes

new connections and collaborations, and inspires future scientific contributions to the community at the NIH.

ACKNOWLEDGEMENTS

We are grateful to the Training and Scientific Directors of the NIH Institutes and Centers, the Graduate

Partnerships Program (GPP) Directors, and the Graduate Student Council (GSC) for their continuous support

of the graduate student community and for the opportunity to recognize the achievements of the NIH graduate

students at this symposium. We would like to thank Dr. Gail Seabold, Dr. Angel Abner De La Cruz Landrau, and Dr.

Jodian Brown for organizing the symposium poster session, and we acknowledge the effort of the postdoctoral

fellow and staff scientist judges for helping to make the poster competition possible. We would like to thank

the 2017 GSC co-chairs, Carly Starke and Keyla Tumas, for managing the Outstanding Mentor Awards and for

all of their efforts and dedication to the GSC and graduate student community. This symposium would not be

possible without the help of the Office of Intramural Training and Education (OITE). We are especially thankful

for Dr. Sharon Milgram, Dr. Philip Wang, Dr. Phil Ryan and other OITE staff who have contributed significantly

to the planning of this event. We would like to extend a big thank you to Dr. Eric Betzig for his enthusiasm and

willingness to deliver our keynote address. Finally, we would like to thank the graduate students, mentors,

alumni, and all attendees whose participation made this event successful.

THE 14TH ANNUAL NIH GRADUATE RESEARCH SYMPOSIUM COMMITTEE

Keyla Tumas, NIAID/Georgetown University

Lampouguin Yenkoidiok Douti, NIAID/University of Maryland

Larissa Erben, NICHD/University of Bonn, Germany

Laura Marler, NICHD/Johns Hopkins University

Ruby Lam, NCCIH/Brown University

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9:00 am-10:00 am

Registration in Natcher Conference Center Lower Lobby

ELEVATOR PITCH COMPETITION

10:00 am-11:30 am

Ruth L. Kirschstein Auditorium

WELCOME AND KEYNOTE ADDRESS

Sharon L. Milgram, PhD Director, NIH Office of Intramural Training & Education (OITE)

Eric Betzig, Ph.D. Nobel Laureate Group Leader, Janelia Research Campus, Howard Hughes Medical Institute

12:00 pm-1:00 pm

Atrium

POSTER SESSION I

Odd numbered posters presenting

1:00 pm-2:00 pm

Atrium

POSTER SESSION II

Even numbered posters presenting

2:15 pm-3:45 pm


STUDENT ORAL PRESENTATIONS

Andrew Kesner, Johns Hopkins University, NIDA

Optogenetic interrogation of an understudied brain region suggests a role in motivated behaviors

Neelam Panchal, University College London, NIAID

T cell gene therapy corrects humoral and cytotoxic defects in X-linked lymphoproliferative disease type 1 (XLP1)

Kevin Hughes, Yale Univeristy, NCI

Identifying conditions that regulate expression of a “RNA Repair” operon in Salmonella

Kim Breglio, University of Oxford, NCATS

Phenotypic changes and drug sensitivity associated with an ATG18 mutation in Plasmodium falciparum

3:45 pm-4:45 pm


AWARDS CEREMONY

Graduation Ceremony

Certificates presented by:Sharon L. Milgram, PhD, Director, NIH Office of Intramural Training & Education

Outstanding Mentor AwardsLisa Cunningham, PhD, NIDCDVeronica A. Alvarez, PhD, NIAAALaura M. Koehly, PhD, NHGRITodd Macfarlan, PhD, NICHD

NIH Graduate Student Research Awards (NGSRAs)

Awarded to the winners of the poster competition

PROGRAM OF EVENTS LOCATION: NATCHER CONFERENCE CENTER (NIH BUILDING 45)


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GPP GRADUATION AWARD RECIPIENTS

GPP GRADUATION AWARD RECIPIENT, DISSERTATION TITLE

NIH IC, MENTOR

UNIVERSITY, UNIVERSITY MENTOR

Monique Rochelle Anderson The Role of HTLV-1 in Alteration of Immune Regulation Through Regulatory T cell Dysfunction and Exosomal Manipulation

NINDS Dr. Steven Jacobson

University of Virginia Dr. Michael Brown

Andrew Michael Breglio Mechanisms of Clinical Ototoxicity and Inner Ear Protection

NIDCD Dr. Lisa Cunningham

University of Oxford Dr. Matthew Wood

Christie Kay Campla Rod Photoreceptor Specific Expression and Function of Frmpd1 (FERM and PDZ Domain Containing 1)

NEI Dr. Anand Swaroop

University of Oxford Dr. Stephanie Halford, Dr. Sumathi Sekaran

Akanni Clarke Propulsion by Actin Flux: the Abelson Tyrosine Kinase Regulates a Novel Mechanism of Actin Based Motility that Drives the Growth and Guidance of Axons in vivo

NINDS Dr. Edward Giniger

George Washington University Dr. Sally Moody

Angel Abner de la Cruz Landrau Insights on the Gating Mechanism of a Voltage-gated Potassium Channel Using Metal Bridges and Methanethiosulfonate Crosslinkers

NINDS Dr. Miguel Holmgren

Universidad Central del Caribe Dr. Misty Eaton, Dr. Mikhail Inyushin

Ignacio Navas Enamorado Differential Influence of Anaerobic and Aerobic Exercises in Aging

NIA Dr. Rafael de Cabo, Dr. Michel Bernier

University of Pablo de Olavide Dr. Gloria Brea Calvo

Rebecca Virginia Fallon Locomotor Sensitization to Amphetamine is Encoded by Nucleus Accumbens Fos-expressing Neuronal Ensembles in a Context-specific Manner

NIDA Dr. Bruce Hope

Johns Hopkins University

Rabia Faridi Molecular Characterization of Syndromic and Nonsyndromic Forms of Deafness Using Molecular Genetic Approaches

NIDCD Dr. Thomas B. Friedman, Dr. Dennis T. Drayna

University of the Punjab Dr. Sheikh Riazuddin, Dr. Asma Ali Khan

Passley Hargrove Endocytosis-associated Rabgef1 Facilitates the Biogenesis of Outer Segments in Mammalian Photoreceptors

NEI Dr. Anand Swaroop

George Washington University Dr. Sally Moody

Seong-In Hyun Topological Analysis and Functional Characterization of Vaccinia Virus Morphogenesis Proteins

NIAID Dr. Bernard Moss

University of Maryland, College Park

Angela M. Ianni Characterization of the Effect of Dopamine on the Neural Coding of Reward-Based Learning and Decision-Making

NIMH Dr. Karen Berman

University of Oxford Dr. Tim Behrens

Matthew James Jacobs Advanced Image Processing in Cardiac Magnetic Resonance Imaging with Application in Myocardial Perfusion Quantification

NHLBI Dr. Andrew E. Arai, Dr. Li-Yueh Hsu

The Catholic University of America Dr. Lin-Ching Chang

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NIH IC, MENTOR


Michael R. Jones Free Energy Simulations of Post-Translational Modifications to Proteins

NHLBI Dr. Bernard Brooks

Michigan State University Dr. Angela K. Wilson

Konrad Juczewski Touching Cognition: Somatosensory Processing and Plasticity Deficits in Mouse Barrel Cortex

NIAAA Dr. David M. Lovinger

Karolinska Institutet Dr. Patrik Krieger, Dr. Kevin D. Fox, Dr. Gilad Silberberg, Dr. Sten Grillner

Parisa Karimi Environmental Contaminants and Diabetes Mellitus

NCI Dr. Constanza M. Camargo

George Washington University

Andrea Kennard The Role of Sexual Recombination in the Evolution of the Protozoan Parasite, Toxoplasma gondii

NIAID Dr. Michael E. Grigg


Vincent P. Kunze Genetic Profiling of a Cone-Dominated Retina and Cone Photoreceptor Subtypes

NEI Dr. Wei Li

Carl von Ossietzky University of Oldenburg Dr. Karl-Wilhelm Koch

Gleb Andrejevich Kuzmin Dose and Risk Assessment for Epidemiological Studies Investigating Long-Term Side Effects of Proton Therapy

NCI-DCEG Dr. Choonsik Lee

Texas A&M University

Graziella Madeo Profiling the Vulnerability of Nigrostriatal Circuit in Parkinson's Disease: Focus on PINK1 and α-Synuclein.

NIDA Dr. Antonello Bonci

University of Rome Tor Vergata Dr. Antonio Pisani

Gregory D. Marquart Construction and Utilization of Digital Brain Atlases in Larval Zebrafish

NICHD Dr. Harold A. Burgess

University of Maryland, College Park Dr. Jens Herberholz

Swapna G. Naik Molecular Cloning, Purification, and Characterization of the Caenorhabditis elegans Phosphodiesterase 3 (CEPDE3) gene

NHLBI Dr. Vincent C. Manganiello

University of Sunderland Dr. Noel Carter

Dani Rubinstein Working Memory-Related Prefrontal Activity Measured with Magnetoencephalography: Abnormalities in Schizophrenia and Relationship to Dopamine

NIMH Dr. Karen Berman, Dr. Richard Coppola

Brown University Dr. David Sheinberg

Lana J. SargentEstablishing Biological Plausibility for Cognitive Frailty: A Population Predictive Model

NIADr. Andrew Singleton

Medical University of South CarolinaDr. Elaine Amella

Luca Schifanella Immune Correlates of SIV-Protection and HIV-Control: Study of an Effective ALVAC/SIV – gp120/Alum Vaccine and of HIV-infected Long Term Non Progressors

NCI Dr. Genoveffa Franchini

Università degli Studi di MilanoDr. Claudia Balotta

Ayesha Sengupta Mechanisms of Serotonergic Control in Fear-Related Neural Circuits and Behaviour

NIAAA Dr. Andrew Holmes

University of Oxford Dr. Trevor Sharp, Dr. David Bannerman

GPP GRADUATION AWARD RECIPIENTS


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NIH IC, MENTOR


Shahriar Sheikhbahaei Astroglial Control of the Brainstem Respiratory Circuits

NINDS Dr. Jeffrey C. Smith

University College London Dr. Alexander V. Gourine

Benjamin Suarez-Jimenez The Role of Spatial Location in Threat Memory: Modulation of Learning and Discrimination

NIMH Dr. Daniel S. Pine, Dr. Monique Ernst

University College London Dr. Neil Burgess

Alisa Anping Suen Role of the SIX1 Oncoprotein in Endometrial Cancer Caused by Neonatal Xenoestrogen Exposure

NIEHS Dr. Carmen Williams

University of North Carolina at Chapel Hill

Mayank Tandon The Immune-Epithelial Interaction in the Pathogenesis of Sjögren's Syndrome

NIDCR Dr. Ilias Alevizos

Thomas Jefferson University Dr. Catherine Calkins

Raquel Velazquez-Kronen Health Risks Associated with Protracted Low-Dose Occupational Radiation Exposure in U.S. Radiologic Technologists

NCI-DCEG Dr. Cari Kitahara, Dr. Martha Linet

University at Buffalo, The State University of New York Dr. Kirsten Moysich, Dr. Jo Freudenheim

Marco Venniro Neural Mechanisms of Relapse to Methamphetamine Seeking after Voluntary Abstinence in a Rat Model

NIDA Dr. Yavin Shaham

University of Verona Dr. Cristiano Chiamulera

Chen Wang Ligand Preferences of Innate Immune Receptors RIG-I and LGP2

NIAID Dr. Joseph Marcotrigiano

Rutgers, The State University of New Jersey Dr. Smita Patel

Cuicui Wang Acute Inflammation Effects of Personal Exposure to Fine-particulate Air Pollution May be Mediated by Methylation

NIEHS Dr. Clarice R. Weinberg

Fudan University

Kristen R. Weaver Brain-gut Axis Dysregulation in Patients with Irritable Bowel Syndrome; An Exploratory Investigation for Markers of Stress

NINR Dr. Wendy A. Henderson

New York University

Mary Weston Investigating the Role of Chloride in Endocytic Organelle Acidification

NINDS Dr. Joseph Mindell


Michaela Willi Super-Enhancers and Genetic Boundaries in the Mammary Gland

NIDDK Dr. Lothar Hennighausen

Medical University Innsbruck Dr. Zlatko Trajanoski

Qinglu Yang Deep Brain Stimulation and Cognitive Function in Parkinson’s Disease

NINDS Dr. Mark Hallett, Dr. Silvina Horovitz

Sun Yat-sen University Dr. Zulin Dou, Dr. Weihong Qiu

Zhe Zhang Elucidating the Function of Fis1

NINDS Dr. Richard Youle

East China Normal University Dr. Shuzhe Ding

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Eric Betzig is a Group Leader at the Janelia Research Campus in Ashburn, VA. His

thesis at Cornell University (PhD ’88) and subsequent work as a PI at AT&T Bell Labs

involved the development of near-field optics – an early form of super-resolution

microscopy. Tiring of academia, he resigned, and in 1995 published the concept that

would become localization microscopy while unemployed. He eventually served

as VP of R&D at Ann Arbor Machine Tool Company, but resigned in 2002 when the

technologies he developed there failed commercially. In 2005, he and his fellow Bell

Labs expatriate, Harald Hess, used photoactivated fluorescent proteins to bring

super-resolution localization microscopy to reality, building the first prototype in the

living room of Dr. Hess. For this work, he is a co-recipient of the 2014 Nobel Prize in

Chemistry. Today, he continues to work in super-resolution, as well as with non-

diffracting light sheets for the 4D dynamic imaging of living systems and adaptive

optics to recover optimal imaging performance deep within aberrating tissues.

KEYNOTE SPEAKER


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STUDENT SPEAKERS

Kimberly Breglio is a fourth year DPhil candidate in the NIH Oxford Cambridge

Scholars (NIH-OxCam) Program. Kimberly completed her Bachelors in Science at

McGill University in 2009 with a major in Ecological Determinants of Health and a

minor in Classics. During her undergraduate summers, she worked at Brigham

and Women’s Hospital in the laboratory of Dr. David Soybel, researching the role of

zinc in the acidification of lysosomes in murine macrophages. Following graduation,

Kimberly moved to Iquitos, Peru to study the immunology of malaria in pregnancy

with Dr. OraLee Branch of New York University and the Universidad Nacional de

la Amazonia Peruana. In 2010, Kimberly matriculated at Penn State College of

Medicine, where she has completed three years of medical school. Kimberly was

selected for the Global Health Scholars Program (GHSP) and traveled to Ecuador

and Peru for research projects. In 2013, Kimberly came to the NIH for a Medical

Research Scholars Program fellowship, where she worked under Dr. Irini Sereti and

Dr. Kenneth Olivier in the National Institute of Allergy and Infectious Diseases on

the clinical and immunologic characteristics of HIV-infected patients who developed

Mycobacterium avium complex (MAC) infections. In the NIH-OxCam Program,

Kimberly has been investigating the role of an autophagy-like pathway in the

mechanism of artemisinin-resistant Plasmodium falciparum under the mentorship

of Dr. Katja Simon and Dr. David Roberts at the University of Oxford and Dr. Craig

Thomas at the National Center for Advancing Translational Sciences. Kimberly

is grateful for the support of her many mentors, both official and unofficial, in

pursuing her doctoral research.

Kevin Hughes is a fourth year PhD candidate in the Yale–NIH GPP. Kevin

completed his undergraduate studies in 2013 at Simpson College in Iowa, where

he majored in Biology. During his undergraduate years, he participated in two

National Science Foundation Summer Research Experiences for Undergraduates

programs, which allowed him to conduct research at the University of Iowa on

bacteria signal transduction under the tutelage of Dr. Craig Ellermeier, and at the

University of Wisconsin-Madison on Listeria monocytogenes pathogenesis under

the mentorship of Dr. John Demian-Sauer. After graduation, he was accepted into

the NIH Postbaccalaureate Research and Education Program at Virginia Tech.

During this time, he conducted research in Dr. Daniela Cimini’s lab studying the

effects of mitotic defects on chromosome segregation in mammalian cells. In

2014, he entered Yale’s Biological and Biomedical Sciences PhD program and

joined the lab of Dr. Sandra Wolin, who recently moved to the NCI to become

Chief of the newly established RNA Biology Laboratory. During his time at Yale,

he was awarded a National Science Foundation Graduate Research Fellowship

and was a peer mentor for Yale’s Summer Undergraduate Research Fellowship

program. Currently, as part of the NIH-Yale partnership PhD program, he is

working as a CRTA fellow under the mentorship of Dr. Sandra Wolin whose lab

focuses on understanding the roles of noncoding RNAs and ribonucleoprotein

complexes, including the Ro 60 kDa (Ro60) autoantigen which is a major target

of autoantibodies in patients who have the autoimmune disorder systemic lupus

erythematosus. His thesis research focuses on the role and regulation of a Ro60

ortholog found within a putative RNA repair operon in the pathogenic bacterium

Salmonella Typhimurium. He is grateful for the opportunity to conduct research

under Dr. Sandra Wolin, whose research spans both basic and translational

science and has the potential to impact clinical treatment and diagnostics of

autoimmune disorders such as lupus, as well as for the wonderful experiences he

has obtained from his time working within the NIH community.

Andrew Kesner is a fourth year PhD candidate in the Johns Hopkins–NIH GPP.

Andrew received his BA in Behavioral Biology from Johns Hopkins University in

2012, and it was there he found his passion for biological research while working in

the behavioral neuroendocrinology lab of Dr. Gregory F. Ball. For a senior capstone

project, Andrew studied the effects of mate-separation on expression of brain

stress-hormone receptors in the Australian zebra finch. Andrew then joined the

JHU-GPP program in 2014 after spending two years as an NIH Postbaccalaurate

IRTA Fellow. He is currently conducting his thesis research at the National Institute

on Drug Abuse under the mentorship of Dr. Satoshi Ikemoto. During his thesis

research Andrew used optogenetics – a technique in which neurons are genetically

modified to express light-sensitive ion channels and are influenced via implanted

optic fibers – to discover a pathway in the brain that is rewarding when stimulated,

identifying it as a potential pathway involved in motivational disorders such as drug

addiction, obesity, and depression. He has further characterized this novel brain

reward circuit and is elucidating its role in reward seeking behaviors. Andrew is

grateful for the opportunity to share his data with the fantastic NIH GPP community!

Neelam Panchal is a forth year PhD student at University College London-

Great Ormond Street Institute of Child Health (UCL-GOSICH) working in the lab

of Professor Bobby Gaspar and Dr. Claire Booth. They focus on developing a

lentiviral mediated T cell gene therapy approach for X-linked lymphoproliferative

disease type 1 (XLP1); a primary immune deficiency (PID) caused by mutations

and or deletions in the SH2D1A gene encoding SLAM-associated protein (SAP);

an intracellular adaptor protein involved in the regulation of T cell dependent

immune responses. XLP1 is characterized by increased susceptibility to Epstein-

Barr virus (EBV) infection triggering infectious mononucleosis, Haemaphagocytic

Lymphohistiocytosis and other B cell malignancies. Prior to starting her PhD,

Neelam completed her undergraduate degree at Queen Mary University of London

and graduated with BSc (hons) in Biochemistry. Following on from graduation she

joined Dr. Alexander Hergovich’s lab at UCL Cancer Institute focusing on tumor

suppressor signaling mechanisms, specifically the Hippo pathway. Neelam recently

joined Dr. Pam Schwartzberg's lab here at NIH as a visiting student receiving "The

Bogue Fellowship" award from UCL, to better understand the signaling mechanism

behind XLP1, both pre and post lentiviral mediated gene correction.

STUDENT SPEAKERS


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OUTSTANDING MENTOR AWARD RECIPIENTS

Lisa Cunningham, PhD

Dr. Cunningham initially trained as a clinical audiologist and treated hearing loss

in pediatric and adult patients at Indiana University Medical Center. She became

interested in the cellular biology of the inner ear and got a PhD in Neuroscience

from the University of Virginia. After receiving her post-doc, Dr. Cunningham

started her independent research lab at the Medical University of South Carolina,

working on the cellular and molecular mechanisms that regulate the survival and

death of the sensory receptor cells in the inner ear, which are called hair cells.

Dr. Cunningham joined NIH in 2011 where she currently is a Senior Investigator at

NIDCD. Dr. Cunningham's lab conducts basic, translational, and clinical studies on

sensory hair cell degeneration in the mature inner ear and develops therapeutic

strategies to prevent or reverse hearing loss. Dr. Cunningham works with an

incredibly talented group of trainees and permanent scientists in the lab. Her goal

in mentoring them is to foster an environment of mutual trust and respect and then

make sure each of them is growing their skillset in a way that advances both the

science and the scientist.

Veronica A. Alvarez, PhD

Dr. Alvarez graduated with honors from the School of Natural Sciences and earned

a PhD degree in Neuroscience in 1997 from University of Buenos Aires, Argentina.

She came to the US to train as an electrophysiologist with Dr. John Williams at the

Vollum Institute at Oregon Health & Science University, and she studied the firing

properties of locus coeruleus neurons and its modulation by opioids. Dr. Alvarez

then continued her postdoctoral training with Dr. Bernardo Sabatini at Harvard

Medical School, where she studied mechanisms of functional and morphological

plasticity at glutamatergic synapses using electrophysiology and two-photon

imaging from 2002-2007. In 2008, she was recruited as tenure-track Investigator

in the Intramural Research Program of NIAAA at NIH, where she established

her research program and was granted tenure in 2015. She is currently a Senior

Investigator and Laboratory Chief at NIAAA. Dr. Alvarez holds a secondary

appointment at NIDA and her laboratory receives additional funding from NINDS.

Dr. Alvarez received the NIH Honor Awards in 2015 and the Outstanding Mentor

Award in 2016. In 2017, she was awarded the NIH Innovation Award for the creation

of the Center on Compulsive Behaviors at NIH.

Research Topics Research in the Alvarez laboratory is focused on identifying the circuits and understanding the synaptic mechanisms that drive reward seeking, reinforcement and compulsive behaviors. The Laboratory studies the effects of drugs of abuse on synapses and neuronal connectivity, with a main focus on stimulant drugs and alcohol. They apply multiple techniques ranging from approaches at the cellular and synaptic level to behavioral analysis and in vivo manipulations in wild-type and genetically-engineered mouse models with the purpose of revealing the cellular mechanisms that control reward-motivated behaviors and compulsive actions and drug seeking.

Biography Dr. Alvarez graduated with honors from the School of Natural Sciences and earned aPhD degree in Neuroscience in 1997 from University of Buenos Aires, Argentina. Shecame to the US to trained as an electrophysiologist with Dr. John Williams at the Vollum

Veronica A. Alvarez, PhD Senior Investigator Laboratory on Neurobiology of Compulsive Behaviors National Institute of Alcohol Abuse and Alcoholism National Institutes of Health

continued

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OUTSTANDING MENTOR AWARD RECIPIENTS

Laura M. Koehly, PhD

Dr. Koehly is a Senior Investigator at NIH/NHGRI, where she is the chief of the

Social and Behavioral Research Branch and directs the Social Network Methods

Section. She completed her doctoral studies at the University of Illinois, Urbana-

Champaign in Quantitative Psychology. Dr. Koehly's training in psychology and

statistics, with an expertise in social network analysis, uniquely positions her team

to investigate the role of social context in health. The ongoing programmatic work

in her section aims to improve our understanding of the social contextual factors

that influence health behaviors and psychological adjustment to inherited disease

risk and diagnoses. In so doing, this research can inform tailored approaches

that leverage both genomics and social context to improve health outcomes. This

research is focused on three thematic areas. First, her team investigates the role of

family functioning characteristics on dissemination of hereditary risk information,

encouragement of risk-reducing behaviors, and associated health outcomes in

families affected by both Mendelian genetic disorders and complex conditions.

Second, new research considers caregiving as a network process, with the goal

of identifying factors associated with resilience in the face of stress accompanied

by caring for family members affected by inherited conditions. Finally, Dr. Koehly’s

team benefits from the rich network data that they collect in their research,

including multiple informants from multiple families. This allows her group to

advance new methods for social network data that can be used to model complex

systems to facilitate the exploration of genomic, social, and environmental

contributions to both rare and complex diseases.

Todd Macfarlan, PhD

Dr. Macfarlan earned his PhD in Cell and Molecular Biology from the University of

Pennsylvania in 2000, where he studied the transcriptional repressive properties of

THAP domain proteins, a family of DNA binding proteins that evolved from the DNA

binding domain of P-element transposases. After his PhD, Dr. Macfarlan joined

the laboratory of Samuel Pfaff at the Salk Institute for Biological Studies, where

he demonstrated that endogenous retroviruses (ERVs) play an important role in

mammalian pre-implantation development by providing regulatory sequences for

an entire network of genes that are coordinately regulated by chromatin modifying

factors to control embryonic potential. Dr. Macfarlan won the Presidential Early

Career Award for Scientists and Engineers (PECASE) in 2012 for these studies. Dr.

Macfarlan was then recruited to the NIH in July of 2012 as part of the Earl Stadtman

Investigator Program. As a member of the Division of Developmental Biology,

Todd currently heads the Unit on Mammalian Epigenome Reprogramming, where

he explores the interplay between KRAB-Zinc finger proteins and endogenous

retroviruses and their impact on mammalian development and evolution.


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Poster # Last Name, First IC University

54 Abaandou, Laura NIDDK George Mason University

89 Abramzon, Yevgeniya NIA University College London

32 Ader, Nicholas NINDS University of Cambridge

93 Agbaegbu Iweka, Chinyere NHLBI Georgetown University

58 Almashjary, Majed NHLBI The Catholic University of America

51 Alsaggaf, Rotana NCI-DCEG University of Maryland, Baltimore

48 Aronson, Sarah NIDA University of Maryland School of Medicine, Baltimore

34 Arpino, Gianvito NINDS Karolinska Institutet

112 Avanzato, Victoria NIAID University of Oxford

29 Bao, Lingyu NICHD Xi'an Jiaotong University

57 Barbour, Christopher NINDS Montana State University

65 Benner, Leif NIDDK Johns Hopkins University

121 Breglio, Kimberly NCATS University of Oxford

64 Bregolin Dias, Henrique NCI Pontifícia Universidade Católica do Rio Grande do Sul

61 Brown, Markus NCI University of Maryland, College Park

25 Bullock, Jeanee NEI Georgetown University

125 Burke, Dennis NIAAA Brown University

13 Burnett, Joey NIDDK Brown University

28 Caffrey, Brian NCI University College Dublin

12 Chopp, Laura NCI University of Pennsylvania

60 Cohen, Matan NCI Indiana University, Bloomington

115 Coonahan, Erin NIAID University of Oxford

131 Dashtestani, Hadis NICHD University of Maryland, Baltimore County

27 Demmerle, Justin NICHD University of Oxford

4 De Mets, François NCI Université Libre de Bruxelles

63 Dennis, Allison NICHD Johns Hopkins University

24 Desai, Parth Rakesh NHLBI University of Maryland, College Park

1 Dildine, Troy NCCIH Karolinska Institutet

71 DiPrima, Michael NCI George Washington University

50 Donnelly, Bridget NIDDK Johns Hopkins University

78 Draizen, Eli NLM University of Virginia

97 Erben, Larissa NICHD University of Bonn

72 Fadl, Benjamin NEI Johannes Gutenberg University of Mainz

37 Faridi, Rabia NIDCD University of the Punjab

100 Fernandopulle, Michael NINDS University of Cambridge

STUDENTS Listed alphabetically by name

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55 Fridlyand, Nathan NIAID University of Camerino, Italy

21 Gam, Kaitlyn NIEHS Tulane University

110 Gardner, Cameron NIAID University of Oxford

66 Gasilina, Anjelika NCI Georgetown University

5 Ghane, Merage NIMH Virginia Polytechnic Institute and State University

98 Glotfelty, Elliot NIA Karolinska Institutet

75 Goswami, Meghali NHLBI George Washington University

80 Grant, Christopher NCI Georgetown University

81 Gutierrez Rodrigues, Fernanda NHLBI University of Sao Paulo

8 Haurum Johansen, Kristoffer NHGRI University of Cambridge

109 Heaton, George NIA University College London (UCL)

86 Horuluoglu, Begum NCI Bilkent University

39 Hughes, Kevin NCI Yale University

108 Humble, Stewart NINDS University of Oxford; LSUHSC New Orleans

41 Inwood, Sarah NIDDK Johns Hopkins University

68 Islam, Rafique NHLBI George Mason University

49 Ivovic, Aleksandra NIAMS University of Cambridge

16 Karmele, Erik NIAID George Washington University

90 Kayraklioglu, Neshlihan NCI Hacettepe University

3 Kesner, Andrew NIDA Johns Hopkins University

76 Khan, Mohd M. NIAID University of Maryland School of Medicine, Baltimore

106 Lam, Ruby NCCIH Brown University

103 Lee, Nathanael NINDS Georgetown University

36 Lefeuvre, Jennifer NINDS University Pierre et Marie Curie (Paris)

77 Leshem, Yasmin NCI Technion

87 Li, Dan NCI East China Normal University

11 Liang, Jing NIDDK Brown University

88 Liang, Jonathan NIAID University of Cambridge

46 Liao, Tsung-Jen NCI University of Maryland, College Park

73 Liu, Limin NCI Shanghai Jiaotong University

62 Lukasz, Daria NIDCD Johns Hopkins University

20 Magen, Assaf NCI University of Maryland, College Park

35 Marler, Laura NICHD Johns Hopkins University

104 Martin, Christian D. NIMH Imperial College London

STUDENTS Listed alphabetically by name


15


102 Matson, Kaya NINDS Johns Hopkins University

18 Matus Nicodemos, Rodrigo NIAID Johns Hopkins University

69 Michael, Helen NCI University of Maryland, College Park

85 Miller, Brendan NHGRI Johns Hopkins University

94 Mukhamedova, Maryam NIAID Johns Hopkins University

14 Nabar, Neel NIAID Karolinska Institutet

17 Nickolls, Alec NINDS Brown University

52 Ortolan, Davide NEI University of L'Aquila

92 Paiano, Jacob NCI University of Pennsylvania

123 Panchal, Neelam NIAID University College London

26 Patange, Simona NCI University of Maryland, College Park

38 Pearson, Craig NHLBI University of Cambridge

117 Pei, Luxin NIAID Johns Hopkins University

119 Phung, Emily NIAID George Washington University

30 Pitt, Ashley NIDDK Johns Hopkins University

107 Pourshafie, Naemeh NINDS George Washington University

7 Prescott, Stephanie NINR University of Virginia

45 Prestil, Ryan NINDS University of Cambridge

114 Rao, Nina NCI-DCEG Johns Hopkins University

44 Rimland, Casey NIAID University of Cambridge

42 Roney, Joseph NINDS University of Oxford

95 Rosenthal, Justin NINDS University of Maryland, College Park

96 Rusch, Heahter NIMH Karolinska Institutet

83 Schmidt, Keith NCI Utrecht University

127 Schneider Nunes, Natalia CC Universidade Federal do Rio Grande do Sul

129 Schneller, Jessica NHGRI SUNY Stony Brook

31 Sciascia, Nicholas NCI George Washington University

19 Seidlitz, Jakob NIMH University of Cambridge

74 Seifuddin, Fayaz NHLBI George Mason University

84 Sek, Albert NIAID University of California, Los Angeles (UCLA)

59 Sekiguchi, Rei NIDCR University of Missouri-Kansas City

9 Sengupta, Ayesha NIAAA University of Oxford

82 Shaikh, Ahmad NHLBI Catholic University of America

99 Sheikhbahaei, Shahriar NINDS University College London

16


56 Shumway, Lukas NIDA Johns Hopkins University

15 Silverstein, Shana NIAAA University College London

105 Smith, Andrew NEI University College Dublin

79 Song, Qi NCI Fudan University

2 Starke, Carly Elizabeth NIAID Georgetown University

113 Steel, Adam NIMH University of Oxford

67 Stevens, Evan NIAMS University of Texas Southwestern

53 Tisza, Mike NCI Johns Hopkins University

40 Trychta, Kathleen NIDA University of Maryland, Baltimore

6 Tumas, Keyla NIAID Georgetown University

22 Walls, Jessica NCI Trinity College Dublin

23 Winkelsas, Audry NINDS University of Oxford

43 Wong, Hiu-tung Candy NIDCD Johns Hopkins University

91 Wong, Sing Wai NIEHS University of North Carolina at Chapel Hill

70 Xiao, Yanzi NCI-DCEG Johns Hopkins University

101 Xin, Wendy NIDA Johns Hopkins University

33 Yau, Ka Chun NICHD The Chinese University of Hong Kong

10 Yenkoidiok Douti, Lampouguin NIAID University of Maryland, College Park

116 Zabala-Aleman, Gabriela NIMH Universidad Central del Caribe

47 Zhang, Haoyu NCI-DCEG Johns Hopkins University

111 Zhao, Jie NCI Hebei Medical University


17

1Artificial Intelligence, Can it Provide More Equitable Pain Assessment?Troy C. Dildine, Lauren Y. AtlasGraduate Student Name: Troy C. DildineNIH Institute-Center: NCCIHNIH Research Advisor: Dr. Lauren Y. AtlasUniversity Research Advisor: Dr. Andreas OlssonGraduate University: Karolinska Institutet

2Signatures of Protective SIV-Specific CD8+ T CellsCarly Elizabeth C. Starke, Jason M. BrenchleyGraduate Student Name: Carly Elizabeth C. StarkeNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Jason M. BrenchleyGraduate University: Georgetown University

3Optogenetic Interrogation of an Understudied Brain Region Suggests a Role in Motivated BehaviorsAndrew J. Kesner, Satoshi IkemotoGraduate Student Name: Andrew J. KesnerNIH Institute-Center: NIDANIH Research Advisor: Dr. Satoshi IkemotoGraduate University: Johns Hopkins University

4Regulation of Acetate Metabolism: Coordination with the TCA Cycle via a Processed Small RNAFrançois De Mets, Susan GottesmanGraduate Student Name: François De MetsNIH Institute-Center: NCINIH Research Advisor: Dr. Susan GottesmanUniversity Research Advisor: Dr. Laurence Van MelderenGraduate University: Université Libre de Bruxelles

5Modeling the Behavioral and Neural Substrates of Decision-Making Under Perceptual and Reward UncertaintyMerage Ghane, Shruti A. Japee, John A. Richey, Leslie G. UngerleiderGraduate Student Name: Merage GhaneNIH Institute-Center: NIMHNIH Research Advisor: Dr. Leslie G. UngerleiderUniversity Research Advisor: Dr. John A. RicheyGraduate University: Virginia Polytechnic Institute and State University

6Characterizing the Host Immune Responses in Rodent Malaria Parasite N67C Infections to Identify Possible Treatment AvenuesKeyla C. Tumas, Jian Wu, Norinne Lacerda Queiroz, Xiao He, Yu-Chih Peng, Xin-zhuan SuGraduate Student Name: Keyla C. TumasNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Xin-zhuan SuUniversity Research Advisor: Dr. Steven SingerGraduate University: Georgetown University

7Antibiotic Exposure During Gestation Increases Obesity on a Western DietStephanie M. Prescott, Ernesto Perez-Chanona, Wendy Henderson, Giorgio TrinchieriGraduate Student Name: Stephanie M. Prescott, MSN, NNP-BCNIH Institute-Center: NINRNIH Research Advisor: Dr. Wendy HendersonUniversity Research Advisor: Dr. Jessica Keim-MalpassGraduate University: University of Virginia

8Evaluation of the Role of Novel PI3K Effector Proteins in T Cell AdhesionKristoffer H. Johansen, Bonnie Huang, Madeline Epping, Jennifer Cannons, Senta Kapnick, Fabien Garçon, Klaus Okkenhaug, Pamela SchwartzbergGraduate Student Name: Kristoffer H. JohansenNIH Institute-Center: NHGRINIH Research Advisor: Dr. Pamela SchwartzbergUniversity Research Advisor: Dr. Klaus OkkenhaugGraduate University: University of Cambridge

95-HT Neurons Regulate Fear Learning by Modulating Basal Amygdala CircuitsAyesha Sengupta, Marco Capogna, David M. Bannerman, Trevor Sharp, Andrew HolmesGraduate Student Name: Ayesha SenguptaNIH Institute-Center: NIAAANIH Research Advisor: Dr. Andrew HolmesUniversity Research Advisor: Prof. Trevor Sharp and Prof. David M. BannermanGraduate University: University of Oxford

10Developing a Mouse Model to Study "P47" as a Malaria Transmission Blocking TargetLampouguin Yenkoidiok Douti, Gaspar E. Canepa, Carolina Barillas-MuryGraduate Student Name: Lampouguin Yenkoidiok DoutiNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Carolina Barillas-MuryUniversity Research Advisor: Dr. Christopher JewellGraduate University: University of Maryland, College Park

POSTERS

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11Realtime State-Dependent Hypothalamic Activity During a Concomitant Behavioral Choice ParadigmJing W. Liang, Chia Li, C. Joseph Burnett, Jovana S. Navarrete, Michael J. KrashesGraduate Student Name: Jing W. LiangNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Michael J. KrashesGraduate University: Brown University

12Investigating CD4 Lineage Differentiation in the ThymusLaura B. Chopp, Rémy BosselutGraduate Student Name: Laura B. ChoppNIH Institute-Center: NCINIH Research Advisor: Dr. Rémy BosselutUniversity Research Advisor: Dr. David AllmanGraduate University: University of Pennsylvania

13Natural and Artificial Hunger Gate Social Behavioral ChoiceC. Joseph Burnett, Samuel C. Funderburk, Chia Li, Jovana Naverrete, Jing Liang, Michael J. KrashesGraduate Student Name: C. Joseph BurnettNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Michael J. KrashesGraduate University: Brown University

14LRRK2 activates Transcription Factor EB via a CD38-NAADP-TPC2 dependent pathway with effects on B cell migration and macrophage IL-1B releaseNeel R. Nabar, Chong Shan Shi, Mikael C. Karlsson, John H. KehrlGraduate Student Name: Neel R. NabarNIH Institute-Center: NIAIDNIH Research Advisor: Dr. John H. KehrlUniversity Research Advisor: Dr. Mikael C. KarlssonGraduate University: Karolinska Institutet

15Prefrontal Regulation Underlying Observational Fear LearningShana E. Silverstein, Mio Nonaka, Olena Bukalo, Aaron W. Limoges, Ozge Gunduz-Cinar, Andrew HolmesGraduate Student Name: Shana E. SilversteinNIH Institute-Center: NIAAANIH Research Advisor: Dr. Andrew HolmesUniversity Research Advisor: Dr. Essi VidingGraduate University: University College London

16Anti-IL-13Ra2 therapy promotes recovery from murine inflammatory bowel disease by enhancing the pro-regenerative and anti-inflammatory activity of IL-13Erik P. Karmele, Trisha S. Pasricha, Thirumalai R. Ramalingam, Robert W. Thompson, Richard L. Gieseck III, Kayla J. Knilans, Martin Hegen, Mark Farmer, Fang Jin, Thiago Almeida Pereira, Rafael de Queiroz Prado, Lioudmila Tchistiakov, Marion T. Kasaian, and Thomas A. WynnGraduate Student Name: Erik P. KarmeleNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Thomas A. WynnUniversity Research Advisor: Dr. David LeitenbergGraduate University: George Washington University

17Derivation of Human Sensory Neurons to Model a Novel Disorder of MechanosensationAlec R. Nickolls, Marcin Szczot, Michelle M. Lee, David Espinoza, Rajan Patel, Michael E. Ward, Alexander T. Chesler, Carsten G. BönnemannGraduate Student Name: Alec R. NickollsNIH Institute-Center: NINDSNIH Research Advisor: Dr. Carsten G. BönnemannUniversity Research Advisor: Dr. Justin R. FallonGraduate University: Brown University

18Nef upregulates FasL early while MHCs are downregulated late in HIV-infected cellsRodrigo Matus Nicodemos, Daniel C. Douek, Richard A. KoupGraduate Student Name: Rodrigo Matus NicodemosNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Richard A. KoupGraduate University: Johns Hopkins University

19Morphometric Similarity Networks Detect Microscale Cortical Organisation And Predict Inter-Individual Cognitive VariationJakob Seidlitz, František Váša, Maxwell Shinn, Rafael Romero-Garcia, Kirstie J. Whitaker, Petra E. Vértes, Konrad Wagstyl, Paul Kirkpatrick Reardon, Liv Clasen, Siyuan Liu, Adam Messinger, David A. Leopold, Peter Fonagy, Raymond J. Dolan, Peter B. JonesGraduate Student Name: Jakob SeidlitzNIH Institute-Center: NIMHNIH Research Advisor: Dr. Armin RaznahanUniversity Research Advisor: Dr. Edward BullmoreGraduate University: University of Cambridge

POSTERS


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20Dissecting Tumor Infiltrating Lymphocyte Diversity by single-cell transcriptome analysisAssaf Magen, Thomas Ciucci, Jia Nie, Rémy Bosselut, Sridhar HannenhalliGraduate Student Name: Assaf MagenNIH Institute-Center: NCINIH Research Advisor: Dr. Rémy BosselutUniversity Research Advisor: Dr. Sridhar HannenhalliGraduate University: University of Maryland

21Oil spill cleanup work and lung function among GuLF STUDY participantsKaitlyn B. Gam, Richard K. Kwok, Lawrence S. Engel, Maureen Y. Lichtveld, Dale P. SandlerGraduate Student Name: Kaitlyn B. GamNIH Institute-Center: NIEHSNIH Research Advisor: Dr. Dale P. SandlerUniversity Research Advisor: Dr. Maureen Y. LichtveldGraduate University: Tulane University

22Pkm2 integrates Natural Killer cell metabolism and signalingJessica F. Walls, Clair M. Gardiner, Daniel W. McVicar, David K. FinlayGraduate Student Name: Jessica F. WallsNIH Institute-Center: NCINIH Research Advisor: Dr. Daniel W. McVicarUniversity Research Advisor: Dr. David K. Finlay and Dr. Clair M. GardinerGraduate University: Trinity College Dublin

23Targeting the 5’UTR of survival motor neuron 2 (SMN2) to increase its expression in a disease model of spinal muscular atrophyAudrey M. Winkelsas, Christopher Grunseich, George G. Harmison, Carlo Rinaldi, Melissa Bowerman, Matthew J. Wood, Kenneth H. FischbeckGraduate Student Name: Audrey M. WinkelsasNIH Institute-Center: NINDSNIH Research Advisor: Dr. Kenneth H. FischbeckUniversity Research Advisor: Prof. Matthew J. WoodGraduate University: University of Oxford

24Molecular Dynamics simulation of Supercoiling DNA with base pair mismatchesParth R. Desai, Siddhartha Das, Keir C. NeumanGraduate Student Name: Parth R. DesaiNIH Institute-Center: NHLBINIH Research Advisor: Dr. Keir C. NeumanUniversity Research Advisor: Dr. Siddhartha DasGraduate University: University of Maryland, College Park

25Enzymatic and metabolic products of a distinct phospholipase in the retinaJeanee L. Bullock, S. Patricia BecerraGraduate Student Name: Jeanee L. BullockNIH Institute-Center: NEINIH Research Advisor: Dr. S. Patricia BecerraGraduate University: Georgetown University

26A single cell view of MYC's gene regulatory and oncogenic mechanismSimona Patange, Michelle Girvan, David Levens, Daniel R. LarsonGraduate Student Name: Simona PatangeNIH Institute-Center: NCINIH Research Advisor: Dr. Daniel R. LarsonUniversity Research Advisor: Dr. Michelle GirvanGraduate University: University of Maryland, College Park

27LDB1 regulates transcriptional activation and chromatin organization in motor neuron developmentJustin Demmerle, Carson J. Miller, Gernot Wolf, Ming-an Sun, Sherry Ralls, David Pinto, Lothar Schermelleh, Todd Macfarlan Graduate Student Name: Justin DemmerleNIH Institute-Center: NICHD NIH Research Advisor: Dr. Todd F. Mcfarlan University Research Advisor: Lothar SchermellehGraduate University: University of Oxford

28Nanoparticle Action in the CellBrian J. Caffrey, Lisa Hartnell, Sriram Subramaniam, Kenneth A. DawsonGraduate Student Name: Brian J. CaffreyNIH Institute-Center: NCINIH Research Advisor: Dr. Sriram SubramaniamUniversity Research Advisor: Prof. Kenneth DawsonGraduate University: University College Dublin

29Thyroid Hormone Receptor Coactivator SRC3 Function Analysis under the Postembryonic Development of XenopusLingyu Bao, Yuki Shibata, Bindu D. Paul, Liezhen Fu, Yun-Bo ShiGraduate Student Name: Lingyu BaoNIH Institute-Center: NICHDNIH Research Advisor: Dr. Yun-Bo ShiUniversity Research Advisor: Dr. Bingyin ShiGraduate University: Xi'an Jiaotong University

20

30Recombinant Expression and Characterization of the Mitochondrial Translocase of the Outer Membrane (TOM) complexAshley Pitt, Susan K. BuchananGraduate Student Name: Ashley PittNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Susan K. BuchananUniversity Research Advisor: Dr. Susan K. BuchananGraduate University: Johns Hopkins University

31Exploring the DNA repair dynamics of Topoisomerase-DNA adducts using novel DNA break capture methodsNicholas Sciascia, Andres Canela, Andre Nussenzweig, Norman LeeGraduate Student Name: Nicholas SciasciaNIH Institute-Center: NCINIH Research Advisor: Dr. Andre NussenzweigUniversity Research Advisor: Dr. Norman LeeGraduate University: George Washington University

32Bax-mediated Mitochondrial Membrane RestructuringNicholas R. Ader, Richard J. Youle, Wanda KukulskiGraduate Student Name: Nicholas R. AderNIH Institute-Center: NINDSNIH Research Advisor: Dr. Richard YouleUniversity Research Advisor: Dr. Wanda KukulskiGraduate University: University of Cambridge

33In vivo analysis of RanBP1 and RanBP3 roles in Ran-GTP gradient formation and Ran pathway functionKa Chun Yau, Alexei Arnaoutov, Mary DassoGraduate Student Name: Ka Chun YauNIH Institute-Center: NICHDNIH Research Advisor: Dr. Mary DassoUniversity Research Advisor: Prof. Fung Kwok PuiGraduate University: The Chinese University of Hong Kong

34Filamentous actin mediates vesicle merging with the plasma membrane at synapsesGianvito Arpino, Emma Evergren, Oleg Shupliakov, Ling-Gang WuGraduate Student Name: Gianvito ArpinoNIH Institute-Center: NINDSNIH Research Advisor: Dr. Ling-Gang WuUniversity Research Advisor: Prof. Oleg ShupliakovGraduate University: Karolinska Institutet

35New role for translation initiation factor eIF2β in promoting ribosomal scanning and accurate start codon selection in vivoLaura Marler, Alan G. HinnebuschGraduate Student Name: Laura MarlerNIH Institute-Center: NICHDNIH Research Advisor: Dr. Alan G. HinnebuschUniversity Research Advisor: Dr. Kyle CunninghamGraduate University: Johns Hopkins University

36In vivo Magnetic Resonance Imaging of the Marmoset Spinal Cord at 7TJennifer A. Lefeuvre, Wen-Yang Chiang, Nicholas J. Luciano, Cecil C. Yen, Mathieu D. Santin, Stéphane Lehéricy, Steve Jacobson, Afonso C. Silva, Daniel S. Reich, Pascal SatiGraduate Student Name: Jennifer A. LefeuvreNIH Institute-Center: NINDSNIH Research Advisor: Dr. Pascal SatiUniversity Research Advisor: Dr. Stéphane LehéricyGraduate University: University Pierre et Marie Curie

37A homozygous truncating variant of KCNE1 (p.Tyr46*) associated with deafness reveals a novel genotype-phenotype correlationRabia Faridi, Steven E. Boyden, Risa Tona, Muhammad Zaman Khan Assir, Mohsin Shahzad, Asma Ali Khan, Robert J. Morell, Atteeq U. Rehman, Sheikh Riazuddin, Thomas B. FriedmanGraduate Student Name: Rabia FaridiNIH Institute-Center: NIDCDNIH Research Advisor: Dr. Thomas B. FriedmanUniversity Research Advisor: Dr. Sheikh RiazuddinGraduate University: University of the Punjab

38Modifying Chondroitin Sulfate Proteoglycans Enhances Retinal Ganglion Cell Axon Regeneration in the Mouse Optic NerveCraig S. Pearson, Keith R. Martin, Herbert M. GellerGraduate Student Name: Craig S. PearsonNIH Institute-Center: NHLBINIH Research Advisor: Dr. Herbert M. GellerUniversity Research Advisor: Prof. Keith R. MartinGraduate University: University of Cambridge

39Identifying conditions that regulate expression of a “RNA Repair” operon in SalmonellaKevin J. Hughes, Xinguo Chen, Sandra L. WolinGraduate Student Name: Kevin J. HughesNIH Institute-Center: NCINIH Research Advisor: Dr. Sandra L. WolinGraduate University: Yale University

POSTERS


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40Endoplasmic reticulum exodosis: the departure of resident proteins in response to pathological conditionsKathleen A. Trychta, Susanne M. Bäck, Mark J. Henderson, Brandon K. HarveyGraduate Student Name: Kathleen A. TrychtaNIH Institute-Center: NIDANIH Research Advisor: Dr. Brandon K. HarveyGraduate University: University of Maryland, Baltimore

41Identifying HIPK1 as a target of miR-22-3p Enhancing recombinant protein production from HEK 293 cell by using microarray and HTP siRNA screenSarah Inwood, Eugen Buehler, Michael Betenbaugh, Madhu Lal, Joseph ShiloachGraduate Student Name: Sarah InwoodNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Joseph ShiloachUniversity Research Advisor: Dr. Michael J. BetenbaughGraduate University: Johns Hopkins University

42Identification of Defective Lysosome Transport to Distal Axons as a Potential Mechanism Contributing to Axonal Dystrophy in the Glycosphingolipid Lysosomal Storage Disorder Niemann-Pick Type CJoseph C. Roney, Tamar Farfel-Becker, Mei-Yao Lin, Xiu-Tang Cheng, Sean Cuddy, Frances M. Platt, Zu-Hang ShengGraduate Student Name: Joseph C. RoneyNIH Institute-Center: NINDSNIH Research Advisor: Dr. Zu-Hang ShengUniversity Research Advisor: Prof. Frances M. PlattGraduate University: University of Oxford

43The class III PI3K complex regulates osteoclastogeneisSing-Wai Wong, Laura DeGraff, Xiangxiang Hu, Ching-Chang Ko, Jennifer MartinezGraduate Student Name: Sing-Wai WongNIH Institute-Center: NIEHSNIH Research Advisor: Dr. Jennifer MartinezUniversity Research Advisor: Dr. Ching-Chang KoGraduate University: University of North Carolina at Chapel Hill

44Transcriptomic profiling of human biliary tissues and corresponding in vitro derived organoidsCasey A. Rimland, Samantha Tilson, Carola Morell, Wei Yu Lu, Simone Adams, Richard L. Gieseck III, Hong-Wei Sun, Timothy Meyers, Nikitas Georgakopoulos, Fotios Sampaziotis, Nicholas RF Hannan, Stuart Forbes, Kourosh Saeb-Parsy, Thomas L. Wynn, Ludovic ValGraduate Student Name: Casey A. RimlandNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Thomas L. WynnUniversity Research Advisor: Dr. Ludovic VallierGraduate University: University of Cambridge

45Extracellular Streptavidin-Binding Peptide (SBP) enables magnetic bead purification of transgenic human iPSCsRyan Prestil, Kenneth Fischbeck, Michael WardGraduate Student Name: Ryan PrestilNIH Institute-Center: NINDSNIH Research Advisor: Dr. Kenneth FischbeckUniversity Research Advisor: Prof. David RubinszteinGraduate University: University of Cambridge

46Conformational ensemble of SOS1 upon association with K-Ras4BTsung-Jen Liao, Hyunbum Jang, David Fushman, Ruth NussinovGraduate Student Name: Tsung-Jen LiaoNIH Institute-Center: NCINIH Research Advisor: Dr. Ruth NussinovUniversity Research Advisor: Dr. David FushmanGraduate University: University of Maryland, College Park

47Genome-wide association study (GWAS) identifies 16 novel breast cancer loci from analyses accounting for subtype heterogeneityH. Zhang , J. Lecarpentier , T.U. Ahearn , K. Michailidou , R.L. Milne , P. Kraft , J. Simard , P.D.P Pharoah, M. Schmidt, D. Easton, N. Chatterjee, M. Garcia-Closas, on behalf of the Breast Cancer Association ConsortiumGraduate Student Name: Haoyu ZhangNIH Institute-Center: NCI-DCEGNIH Research Advisor: Dr. Montserrat García-ClosasUniversity Research Advisor: Dr. Nilanjan ChatterjeeGraduate University: Johns Hopkins University

48Transcranial Direct Current Stimulation (tDCS) for the Nicotine Withdrawal SyndromeSarah E. Aronson, Betty Jo Salmeron, Thomas J. Ross, Elliot A. SteinGraduate Student Name: Sarah E. AronsonNIH Institute-Center: NIDANIH Research Advisor: Dr. Elliot A. SteinUniversity Research Advisor: Dr. Asaf KellerGraduate University: University of Maryland School of Medicine

49Examining the somatic mutational repertoire and clonal dynamics in B lymphocytes in Primary Sjogren’s SyndromeAleksandra Ivovic, Paul Milne, Anthony Fullam, Zuoming Deng, Ilias Alevizos, Matthew Collin, Peter Campbell, Richard SiegelGraduate Student Name: Aleksandra IvovicNIH Institute-Center: NIAMSNIH Research Advisor: Dr. Richard SiegelUniversity Research Advisor: Dr. Peter CampbellGraduate University: University of Cambridge

50Interrogating the regulation and function of the mir-35 family of microRNAsBridget F. Donnelly, Katherine McJunkinGraduate Student Name: Bridget F. DonnellyNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Katherine McJunkinGraduate University: Johns Hopkins University

51Benign and Malignant Tumors in The Full Clinical Spectrum of Myotonic Dystrophy Type 1: A UK-CPRD Double Cohort StudyRotana Alsaggaf, Diane Marie M. St. George, Ruth M. Pfeiffer, Youjin Wang, Min Zhan, Kathryn Wagner, Mark H. Greene, Sania Amr, Shahinaz M. GadallaGraduate Student Name: Rotana AlsaggafNIH Institute-Center: NCI-DCEGNIH Research Advisor: Dr. Shahinaz GadallaUniversity Research Advisor: Dr. Diane Marie M. St. GeorgeGraduate University: University of Maryland, Baltimore

52Differentiation of Macular and Peripheral RPE Cells Using In Vitro Morphometric CharacterizationDavide Ortolan, Nathan Hotaling and Kapil BhartiGraduate Student Name: Davide OrtolanNIH Institute-Center: NEINIH Research Advisor: Dr. Kapil BhartiUniversity Research Advisor: Dr. Stefano Di MarcoGraduate University: University of L'Aquila

53Shining A Spotlight on 'Dark Matter' in Animal DNA ViromesMike Tisza, Anca Segall, Nicole Welch, Alberto Peretti, Chris BuckGraduate Student Name: Mike TiszaNIH Institute-Center: NCINIH Research Advisor: Dr. Chris BuckGraduate University: Johns Hopkins University

54Engineering the HEK293 cell line for Improved Protein Expression: OAZ1 knockoutLaura I. Abaandou, Joseph ShiloachGraduate Student Name: Laura I. AbaandouNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Joseph ShiloachUniversity Research Advisor: Dr. Barney BishopGraduate University: George Mason University

55Novel Computational Method Predicts Evolutionarily Conserved Structured RNA Regions in Influenza A Virus and Enterovirus mRNAsNathan Fridlyand, Andrey Chursov, Jonathan Yewdell, Alex ShneiderGraduate Student Name: Nathan FridlyandNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Jonathan YewdellUniversity Research Advisor: Dr. Alexander ShneiderGraduate University: University of Camerino

56KDEL receptor trafficking during endoplasmic reticulum stressLuke Shumway, Brandon K. HarveyGraduate Student Name: Luke ShumwayNIH Institute-Center: NIDANIH Research Advisor: Dr. Brandon K. HarveyGraduate University: Johns Hopkins University

57Constructing Targeted Latent Variables using Longitudinal Data to Develop a More Sensitive Clinical Endpoint for Progressive Multiple SclerosisChristopher R. Barbour, Mark Greenwood, Peter Kosa, Dominique Zosso, Bibiana BielekovaGraduate Student Name: Christopher R. BarbourNIH Institute-Center: NINDSNIH Research Advisor: Dr. Bibiana BielekovaUniversity Research Advisor: Dr. Mark GreenwoodGraduate University: Montana State University

POSTERS


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58Temporal Alterations in Intraerythrocytic Hemoglobin Concentration in Mice Fed Iron Restricted DietMajed Almashjary, Steven Brooks, Hans AckermanGraduate Student Name: Majed AlmashjaryNIH Institute-Center: NHLBINIH Research Advisor: Dr. Hans AckermanUniversity Research Advisor: Dr. Wadad AlSalmiGraduate University: The Catholic University of America

59Tissue- and stage-specific gene expression patterns in organ formationRei Sekiguchi, Kenneth M. YamadaGraduate Student Name: Rei SekiguchiNIH Institute-Center: NIDCRNIH Research Advisor: Dr. Kenneth M. YamadaGraduate University: University of Missouri, Kansas City

60Investigating the regulation of meiotic recombinationMatan Cohen, Michael LichtenGraduate Student Name: Matan CohenNIH Institute-Center: NCINIH Research Advisor: Dr. Michael LichtenGraduate University: Indiana University, Bloomington

61Comprehensive Analysis of the Dynamics of Aberrant WNT Signaling on Global Gene Expression and Higher Order Nuclear StructureMarkus Brown, Scott Ronquist, Sijia Liu, Darawalee Wangsa, Eytan Ruppin, Thomas RiedGraduate Student Name: Markus BrownNIH Institute-Center: NCINIH Research Advisor: Dr. Thomas RiedUniversity Research Advisor: Dr. Eytan RuppinGraduate University: University of Maryland, College Park

62Determining the Relationship Between Hair Cell Synaptic Activity and Neomycin ResistanceDaria Lukasz, Qiuxiang S. Zhang, Candy Wong, Katie S. KindtGraduate Student Name: Daria LukaszNIH Institute-Center: NIDCDNIH Research Advisor: Dr. Katie S. KindtGraduate University: Johns Hopkins University

63Perturbing Transcription through Single Strand BreaksAllison F. Dennis, David J. ClarkGraduate Student Name: Allison F. DennisNIH Institute-Center: NICHDNIH Research Advisor: Dr. David J. ClarkUniversity Research Advisor: Dr. David J. ClarkGraduate University: Johns Hopkins University

64Evaluation of the Effect of Fructose-1,6-Bisphosphate on Fibrosis Development In MiceHenrique Bregolin Dias, Shioko KimuraGraduate Student Name: Henrique Bregolin DiasNIH Institute-Center: NCINIH Research Advisor: Dr. Shioko KimuraUniversity Research Advisor: Dr. Márcio Vinícius Fagundes DonadioGraduate University: Pontifícia Universidade Católica do Rio Grande do Sul

65Sov regulates transposable element activity in the Drosophila ovaryLeif Benner, Cale Whitworth, Kevin Cook, Brian Oliver, Dorothy A. LeritGraduate Student Name: Leif BennerNIH Institute-Center: NIDDKNIH Research Advisor: Dr. Brian OliverGraduate University: Johns Hopkins University

66Probing Signaling Plasticity of ASAP1 ArfGAP in HPV-positive Head and Neck Squamous Cell CarcinomaAnjelika Gasilina, Teresa Vitali, Xiaoying Jian, Huaibin Wang, Jenny E. Hinshaw, Roberto Weigert, Paul A. RandazzoGraduate Student Name: Anjelika GasilinaNIH Institute-Center: NCINIH Research Advisor: Dr. Paul A. RandazzoGraduate University: Georgetown University

67Defining Transcription Factor Networks in Mammalian Immune CellsEvan Stevens, Yongbing Zhao, Anshul Kundaje, Rafael CasellasGraduate Student Name: Evan StevensNIH Institute-Center: NIAMSNIH Research Advisor: Dr. Rafael CasellasGraduate University: University of Texas Southwestern

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68Structure-Function Studies of ApoA-I Mimetic Peptides for ABCA1-dependent Cholesterol Efflux and HDL formationRafique M. Islam, Mohsen Permousa, Scott Gordon, Denis Sviridov, Richard W. Pastor, Alan T. RemaleyGraduate Student Name: Rafique M. IslamNIH Institute-Center: NHLBINIH Research Advisor: Dr. Alan RemaleyUniversity Research Advisor: Dr. Ancha BaranovaGraduate University: George Mason University

69A UV-induced mouse model of melanoma development and progression recapitulates the diversity of BRAF/NRAS wildtype cutaneous melanomaHelen T. Michael, Chi-Ping Day, Antonella Sassano, Huaitian Liu, Patricia Bunda, Maxwell Lee, Glenn MerlinoGraduate Student Name: Helen T. MichaelNIH Institute-Center: NCINIH Research Advisor: Dr. Glenn MerlinoUniversity Research Advisor: Dr. Siba SamalGraduate University: University of Maryland

70Application of a novel whole-genome HPV sequencing approach to clarify the epidemiology and molecular pathogenesis of cervical adenocarcinomaYanzi Xiao, Lisa Mirabello, Meredith Yeager, Kai Yu, Gary M. Clifford, Michael Cullen, Joseph F. Boland, Nicolas Wentzensen, Robert D. Burk, Mark SchiffmanGraduate Student Name: Yanzi XiaoNIH Institute-Center: NCI-DCEGNIH Research Advisor: Dr. Lisa MirabelloUniversity Research Advisor: Dr. Terri Beaty and Dr. Anne RositchGraduate University: Johns Hopkins University

71EphrinB2 provides a survival signal in colon cancer-derived cell linesMichael J. DiPrima, Taekyou Ha, Hyeongil Kwak, Ombretta Salvucci, Giovanna ToasatoGraduate Student Name: Michael J. DiPrimaNIH Institute-Center: NCINIH Research Advisor: Dr. Giovanna TosatoUniversity Research Advisor: Dr. Norman LeeGraduate University: George Washington University

72Identifying Fovea Specific Gene Regulatory Networks in the human retina by combining RNA-seq and DNase-seqBen R. Fadl, Matthew J. Brooks, Rinki Ratnapriya, Vijender Chaitankar, Koray D. Kaya, Anand SwaroopGraduate Student Name: Ben R. FadlNIH Institute-Center: NEINIH Research Advisor: Dr. Anand SwaroopUniversity Research Advisor: Prof. Dr. Uwe WolfrumGraduate University: Johannes Gutenberg University of Mainz

73Pharmacologic inhibition of protein phosphatase-2A with LB-100 induces innate immune mediated anti-metastasis activity when combined with PDL-1 blockadeLimin Liu, Herui Wang, Zhengping ZhuangGraduate Student Name: Limin LiuNIH Institute-Center: NCINIH Research Advisor: Dr. Zhengping ZhuangUniversity Research Advisor: Dr. Jiang LiGraduate University: Shanghai Jiaotong University

74Functional Characterization of Long Non-coding RNAs (lncRNAs)Fayaz Seifuddin, Mehdi Pirooznia, Vijender ChaitankarGraduate Student Name: Fayaz SeifuddinNIH Institute-Center: NHLBINIH Research Advisor: Dr. Mehdi PiroozniaUniversity Research Advisor: Dr. Saleet JafriGraduate University: George Mason University

75Changes in Tumor Microenvironment and T-cell Immune Repertoire Diversity in Acute Leukemia Patients Treated with the Anti-PD1 Agent PembrolizumabMeghali Goswami, Katherine Lindblad, Karolyn Oetjen, Laura Dillon, Catherine Lai, Christopher S. HouriganGraduate Student Name: Meghali GoswamiNIH Institute-Center: NHLBINIH Research Advisor: Dr. Christopher S. HouriganUniversity Research Advisor: Dr. Norman H. LeeGraduate University: George Washington University

76Host-pathogen interactions through systems immunoproteomics approachesMohd M. Khan, Jing Sun, Orna Rabinovich Ernst, Iain D. C. Fraser, Robert K. Ernst, David R Goodlett, Aleksandra Nita-LazarGraduate Student Name: Mohd M. KhanNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Aleksandra Nita-lazarUniversity Research Advisor: Dr. David R. GoodlettGraduate University: University of Maryland School of Medicine, Baltimore

77Synergistic Anti-tumor Activity of Local SS1P with Systemic CTLA-4 Blockade Causes Complete Regression of Both Injected and Un-injected Tumors in MiceYasmin Leshem, James O'Brien, Yoram Reiter, Ira PastanGraduate Student Name: Yasmin LeshemNIH Institute-Center: NCINIH Research Advisor: Dr. Ira PastanUniversity Research Advisor: Dr. Yoram ReiterGraduate University: Technion

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78Predicting host-pathogen potein-protein interactions and molecular mimicry using deep neural networks: A case study in T. gondii and other Apicomplexan parasitesEli J. Draizen, Alexandr Goncearenco, Anna R. Panchenko, Michael E. Grigg, Philip E. BourneGraduate Student Name: Eli J. DraizenNIH Institute-Center: NLMNIH Research Advisor: Dr. Michael E. Grigg and Dr. Anna R. PanchenkoUniversity Research Advisor: Dr. Philip E. BourneGraduate University: University of Virginia

79Development and Characterization of HIF Alpha Inhibitors for Cancer TherapyQi Song, Herui Wang, Jing cui, Xiaoyu Cao, Yingyong Hou, Zhengping ZhuangGraduate Student Name: Qi SongNIH Institute-Center: NCINIH Research Advisor: Dr. Zhengping ZhuangUniversity Research Advisor: Dr. Yingyong HouGraduate University: Fudan University

80Exploring the role of the Dopamine Signaling Axisin NSCLCChristopher E. Grant, Leila Toulabi, Adriana Zingone, Ematu Sesay, Brid RyanGraduate Student Name: Christopher E. GrantNIH Institute-Center: NCINIH Research Advisor: Dr. Brid RyanGraduate University: Georgetown University

81Heterozygous RTEL1 variants in constitutional Bone Marrow FailureFernanda Gutierrez-Rodrigues, Sachiko Kajigaya, James M. Copper, Xingmin Feng, Maria del Pilar F. Ibanez, Rodrigo T. Calado, Danielle M. Townsley, Neal S. YoungGraduate Student Name: Fernanda Gutierrez-RodriguesNIH Institute-Center: NHLBINIH Research Advisor: Dr. Neal S. YoungUniversity Research Advisor: Dr. Rodrigo T. CaladoGraduate University: University of Sao Paulo

82Plasma Proteomic Analysis in Sickle Cell Patients Who Underwent Haploidentical Hematopoietic Stem Cell TransplantAhmad Shaikh, Purevdorj Olkhanud, and Courtney FitzhughGraduate Student Name: Ahmad ShaikhNIH Institute-Center: NHLBINIH Research Advisor: Dr. Courtney FitzhughUniversity Research Advisor: Dr. Chung Byung MinGraduate University: Catholic University of America

83Anti-Tumor Activity in a Mouse Xenograft Model of Prostate Cancer Using CRLX101 – A Novel Investigational Nanoparticle-Drug Conjugate (NDC)Keith T. Schmidt, Jon D. Strope, Phoebe Huang, Jan H. M. Schellens, William D. FiggGraduate Student Name: Keith T. SchmidtNIH Institute-Center: NCINIH Research Advisor: Dr. William D. FiggUniversity Research Advisor: Dr. Jan H. M. SchellensGraduate University: Utrecht University

84Eosinophils Contribute to Muscle Inflammation in Duchenne Muscular DystrophyAlbert C. Sek, Katherine Pak, Michelle Ma, Caroline M. Percopo, Eric Pearlman, James G. Tidball, Helene F. RosenbergGraduate Student Name: Albert C. SekNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Helene F. RosenbergUniversity Research Advisor: Dr. Tomas GanzGraduate University: University of California, Los Angeles

85Detecting DNA Methylation in Minimally-invasive Patient Samples for Cancer DiagnosticsBrendan F. Miller, Thomas Pisanic II, Hanna Petrykowska, Gennady Margolin, Christina M. Annunziata, Tza-Huei Wang, Laura ElnitskiGraduate Student Name: Brendan F. MillerNIH Institute-Center: NHGRINIH Research Advisor: Dr. Laura ElnitskiUniversity Research Advisor: Dr. James TaylorGraduate University: Johns Hopkins University

86Effects of Toll Like Receptor-2/1 Agonist PAM3CSK4 on monocyte differentiation of SLE patients and investigating its role as a therapeutic agentBegum H. Horuluoglu, Defne Bayik, Emilie Goguet, Debra Tross, Dennis M. KlinmanGraduate Student Name: Begum H. HoruluogluNIH Institute-Center: NCINIH Research Advisor: Dr. Dennis M. KlinmanUniversity Research Advisor: Prof. Ihsan GurselGraduate University: Bilkent University

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87Development of CAR T-cell therapy targeting glypican-3 in liver cancerDan Li, Nan Li, Mitchell HoGraduate Student Name: Dan LiNIH Institute-Center: NCINIH Research Advisor: Dr. Mitchell HoUniversity Research Advisor: Dr. Qun WangGraduate University: East China Normal University

88Investigation of Inflammasome and Mitochondrial Dynamics in Macrophage ActivationJonathan Liang, Clinton Bradfield, Iain FraserGraduate Student Name: Jonathan LiangNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Iain FraserUniversity Research Advisor: Prof. Clare BryantGraduate University: University of Cambridge

89Dementias whole genome sequencing projectYevgeniya Abramzon, Michael Nalls, Raphael Gibbs, Dalgard Clifton, Aude Nicolas, Raffaele Ferrari, Smalley June, Jinhui Ding, Ruth Chia, Dagmar Bacikova, Hu Heng-Cheng, Andrew Singleton, John Hardy, Sonja Scholz, Bryan TraynorGraduate Student Name: Yevgeniya AbramzonNIH Institute-Center: NIANIH Research Advisor: Dr. Bryan J. TraynorUniversity Research Advisor: Dr. Pietro FrattaGraduate University: University College London

90Dissecting the effects of TLR7 and TLR8 stimulation of human monocytesNeslihan Kayraklioglu, Dennis M. KlinmanGraduate Student Name: Neslihan KayrakliogluNIH Institute-Center: NCINIH Research Advisor: Dr. Dennis M. KlinmanUniversity Research Advisor: Dr. Dicle GucGraduate University: Hacettepe University

91Hair-cell Ribbon Synapse Formation is Controlled by Calcium Levels in Synaptic Mitochondria and Downstream NAD(H) Redox HomeostasisHiu-tung Candy Wong, Katie KindtGraduate Student Name: Hiu-tung Candy WongNIH Institute-Center: NIDCDNIH Research Advisor: Dr. Katie KindtGraduate University: Johns Hopkins University

92Differential DNA damage responses among tissue resident macrophage populationsJacob J. Paiano, Samira Tamoutounour, Yasmine BelkaidGraduate Student Name: Jacob J. PaianoNIH Institute-Center: NCINIH Research Advisor: Dr. André NussenzweigUniversity Research Advisor: Dr. Craig BassingGraduate University: University of Pennsylvania

93PRG3 Modulates CSPG and LPA Inhibition of Neurite Outgrowth Through the Rhoa-Rock Signaling PathwayChinyere Agbaegbu Iweka, Sharada Tilve, Caitlin Mencio, Panpan Yu, Yasuhiro Katagiri, Mark P Burns, Herbert M. GellerGraduate Student Name: Chinyere Agbaegbu IwekaNIH Institute-Center: NHLBINIH Research Advisor: Dr. Herbert M. GellerUniversity Research Advisor: Dr. Mark BurnsGraduate University: Georgetown University

94RSV Antibody Repertoire Analysis from Memory B Cells from RSV DS-Cav1-Vaccinated Adult VolunteersMaryam Mukhamedova, Emily Phung, Tracy J. Ruckwardt, Michelle C. Crank, Pamela J. Costner, LaSonji A. Holman, Somia P. Hickman, Nina M. Berkowitz, Ingelise J. Gordon, Grace Chen, Julie E. Ledgerwood, Barney S. Graham, John R. MascolaGraduate Student Name: Maryam MukhamedovaNIH Institute-Center: NIAIDNIH Research Advisor: Dr. John MascolaGraduate University: Johns Hopkins University

95Regulating Structural and Functional Plasticity of Drosophila Central Synapses by Tuning the Expression of Nicotinic Acetylcholine ReceptorsJustin Rosenthal, Jun Yin, Anupama Sathyamurthy, Quan YuanGraduate Student Name: Justin RosenthalNIH Institute-Center: NINDSNIH Research Advisor: Dr. Quan YuanUniversity Research Advisor: Dr. Leslie PickGraduate University: University of Maryland, College Park

96Olfactory-based pattern separation in a virtual reality trauma film paradigmHeather L. Rusch; Emily A. Holmes, Johan Lundstrom, Monique Ernst, Christian GrillonGraduate Student Name: Heather L. RuschNIH Institute-Center: NIMHNIH Research Advisor: Dr. Christian GrillonUniversity Research Advisor: Dr. Emily A. HomesGraduate University: Karolinska Institutet

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97A novel ultrasensitive in situ hybridization approach to detect short sequences and splice variants with cellular resolutionLarissa Erben, Ming-Xiao He, Annelies Laeremans, Emily Park, Andres BuonannoGraduate Student Name: Larissa ErbenNIH Institute-Center: NICHDNIH Research Advisor: Dr. Andres BuonannoUniversity Research Advisor: Prof. Andreas ZimmerGraduate University: University of Bonn

98Microglia specific Nogo receptor-1’s influence on inflammation in healthy and Alzheimer’s Disease brainsElliot Glotfelty, David Tweedie, Yazhou Li, Tobias Karlsson, Lars Olson, Nigel GreigGraduate Student Name: Elliot GlotfeltyNIH Institute-Center: NIANIH Research Advisor: Dr. Nigel GriegUniversity Research Advisor: Dr. Lars OlsonGraduate University: Karolinska Institutet

99Glia, bombesin and the sighShahriar Sheikhbahaei, Hidehiko Koizumi, Alexander V. Gourine, Jeffrey C. SmithGraduate Student Name: Shahriar SheikhbahaeiNIH Institute-Center: NINDSNIH Research Advisor: Dr. Jeffrey C. SmithUniversity Research Advisor: Dr. Alexander V. GourineGraduate University: University College London

100Interrogating the molecular pathogenesis of frontotemporal dementia caused by progranulin haploinsufficiencyMichael S. Fernandopulle, Yacheng Liao, Shakib Omari, Amra Saric, Rajan Patel, Maia Parsadanian, Jennifer Lippincott-Schwartz, Michael E. WardGraduate Student Name: Michael S. FernandopulleNIH Institute-Center: NINDSNIH Research Advisor: Dr. Michael E. WardUniversity Research Advisor: Dr. Peter St. George-HyslopGraduate University: University of Cambridge

101Expression and function of glutamine synthetase in oligodendrocytesWendy Xin, Yevgeniya Mironova, Hui Shen, Ari Waisman, Wouter Lamers, Dwight Bergles, Antonello BonciGraduate Student Name: Wendy XinNIH Institute-Center: NIDANIH Research Advisor: Dr. Antonello BonciUniversity Research Advisor: Dr. Antonello BonciGraduate University: Johns Hopkins University

102Learning to Move: the Role of Activity-Dependent Transcription Kaya Matson, Ariel LevineGraduate Student Name: Kaya MatsonNIH Institute-Center: NINDSNIH Research Advisor: Dr. Ariel LevineGraduate University: Johns Hopkins University

103Spatiotemporal Distribution of Fibrinogen in Marmoset Experimental Autoimmune Encephalomyelitis and Human Multiple Sclerosis Inflammatory Demyelinating LesionsNathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Nicholas J. Luciano, Jennifer Lefeuvre, Matthew K. Schindler, Emily C. Leibovitch, Jae Kyu Ryu, Mark A. Petersen, Afonso C. Silva, Steven Jacobson, Katerina Akassoglou, Daniel S. ReichGraduate Student Name: Nathanael J. LeeNIH Institute-Center: NINDSNIH Research Advisor: Dr. Daniel S. ReichUniversity Research Advisor: Dr. Jeffrey K. HuangGraduate University: Georgetown University

104Alpha-frequency phase enables both top-down and bottom-up information transfer in macaque auditory cortex through differential cross-frequency interactionsChristian David Márton, Makoto Fukushima, Simon S. Schultz, Bruno B. AverbeckGraduate Student Name: Christian David MártonNIH Institute-Center: NIMHNIH Research Advisor: Dr. Bruno B. AverbeckUniversity Research Advisor: Dr. Simon S. SchultzGraduate University: Imperial College London

105Elucidating the molecular function of the novel cone photoreceptor enriched factor Clusterin-like 1 (CLUL1)Andrew J. Smith, Brendan Kennedy, Anand SwaroopGraduate Student Name: Andrew J. SmithNIH Institute-Center: NEINIH Research Advisor: Dr. Anand SwaroopUniversity Research Advisor: Dr. Brendan KennedyGraduate University: University College Dublin

106Genetic identification of meningeal afferents and their targets in the brainRuby M. Lam, Lars Von Buchholtz, Nicholas Ryba, Alexander T. CheslerGraduate Student Name: Ruby M. LamNIH Institute-Center: NCCIHNIH Research Advisor: Dr. Alexander T. CheslerUniversity Research Advisor: Dr. Gilad BarneaGraduate University: Brown University

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107A role for NEAT1 in the pathogenesis of spinal bulbar muscular atrophyNaemeh Pourshafie, Chris Grunseich, Kenneth FischbeckGraduate Student Name: Naemeh PourshafieNIH Institute-Center: NINDSNIH Research Advisor: Dr. Kenneth FischbeckUniversity Research Advisor: Dr. Norman LeeGraduate University: George Washington University

108Elucidating the role of progranulin in FTD-associated lysosomal dysfunctionStewart W. Humble, Michael E. WardGraduate Student Name: Stewart W. HumbleNIH Institute-Center: NINDSNIH Research Advisor: Dr. Michael E. WardUniversity Research Advisor: Dr. Richard Wade-MartinsGraduate University: University of Oxford; Louisiana State University Health, New Orleans

109Identifying functional interactors of Parkinson’s disease associated protein LRRK2George Heaton, Ravindran Kumaran, Alexandra Beilina, Dorien Roosen, Yan Li, Michael Nalls, Kirsten Harvey, Mark CooksonGraduate Student Name: George R. HeatonNIH Institute-Center: NIANIH Research Advisor: Dr. Mark CooksonUniversity Research Advisor: Dr. Kirsten HarveyGraduate University: University College London

110Interrogation and Engineering of iPSC Derived T Cells Using Programmable NucleasesCameron L. Gardner, Luigi NotarangeloGraduate Student Name: Cameron L. GardnerNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Luigi NotarangeloUniversity Research Advisor: Prof. Oreste AcutoGraduate University: University of Oxford

111Mechanism of Triptolide-induced HepatotoxicityJie Zhao, Cen Xie, Xiyan Mu, Kristopher W. Krausz, Shogo Takahashi, Tingting Yan, Yuhong Luo, Qiong Wang, Qiao Wang, Frank J. GonzalezGraduate Student Name: Jie ZhaoNIH Institute-Center: NCINIH Research Advisor: Dr. Frank J. GonzalezUniversity Research Advisor: Dr. Qiao WangGraduate University: Hebei Medical University

112Structural Analysis of Bat Antibodies Provides a Molecular-level Understanding of the Humoral Response to Viral Infection in Reservoir SpeciesVictoria A. Avanzato, Alice Stelfox, Vincent Munster, Thomas A. BowdenGraduate Student Name: Victoria A. AvanzatoNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Vincent MunsterUniversity Research Advisor: Dr. Thomas A. BowdenGraduate University: University of Oxford

113Metabolite cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables 1H magnetic resonance spectroscopic imaging at 3 Tesla in a clinically feasible timeframeAdam Steel, Mark Chiew, Peter Jezzard, Natalie Voets, Puneet Plaha, M. Albert Thomas, Chris I. Baker, Charlotte J. Stagg, Uzay E. EmirGraduate Student Name: Adam SteelNIH Institute-Center: NIMHNIH Research Advisor: Dr. Chris I. BakerUniversity Research Advisor: Dr. Charlotte J. StaggGraduate University: University of Oxford

114Patterns of APOBEC Mutagenesis in Patients from the New England Bladder Cancer CohortNina Rao, Ludmila Prokunina-Olsson, Stella Koutros, Michael DeanGraduate Student Name: Nina RaoNIH Institute-Center: NCI-DCEGNIH Research Advisor: Dr. Ludmila Prokunina-Olsson and Dr. Michael DeanGraduate University: Johns Hopkins University

115A Point-of-Care Assay to Detect Antimalarial Drugs from Finger Stick Blood SamplesErin Coonahan, Maarten De Vos, Joel Tarning, Tom Wellems, Carole LongGraduate Student Name: Erin CoonahanNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Carole Long and Dr. Tom WellemsUniversity Research Advisor: Dr. Joel Tarning and Dr. Maarten De VosGraduate University: University of Oxford

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116Visual two-armed bandit reinforcement learning in rodentsGabriela Zabala-Aleman, Johann Du Hoffmann, Yogita Chudasama , Bruno AverbeckGraduate Student Name: Gabriela Zabala-AlemanNIH Institute-Center: NIMHNIH Research Advisor: Dr. Bruno AverbeckGraduate University: Universidad Central del Caribe

117Characterization of Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Hematopoietic Stem Cell Transplant PatientsLuxin Pei, Maura Manion, Dimana Dimitrova, Jennifer Kanakry, Irini SeretiGraduate Student Name: Luxin PeiNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Irini SeretiGraduate University: Johns Hopkins University

119Defining the B-Cell Response to a Stabilized Pre-Fusion Respiratory Syncytial Virus F Subunit Protein VaccineEmily Phung, Maryam Mukhamedova, Tracy J. Ruckwardt, Sarah Andrews, Kaitlyn M. Morabito, Azad Kumar, Pamela J. Costner, LaSonji A. Holman, Somia P. Hickman, Grace Chen, Julie E. Ledgerwood, Michelle C. Crank, John R. Mascola, Barney S. GrahamGraduate Student Name: Emily PhungNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Barney S. GrahamUniversity Research Advisor: Dr. Rebecca M. LynchGraduate University: George Washington University

121Phenotypic changes and drug sensitivity associated with an ATG18 mutation in Plasmodium falciparumKimberly F. Breglio, Roberto Amato, Richard T. Eastman, David Roberts, Anna Katharina Simon, Craig J. ThomasGraduate Student Name: Kimberly F. BreglioNIH Institute-Center: NCATSNIH Research Advisor: Dr. Craig J. ThomasUniversity Research Advisor: Dr. Anna Katharina SimonGraduate University: University of Oxford

123T cell gene therapy corrects humoral and cytotoxic defects in X-linked lymphoproliferative disease type 1 (XLP1)Neelam Panchal, Benjamin Houghton, Begona Diez, Adrian Thrasher, Bobby Gaspar, Claire Booth, Pamela SchwartzbergGraduate Student Name: Neelam PanchalNIH Institute-Center: NIAIDNIH Research Advisor: Dr. Pamela SchwartzbergUniversity Research Advisor: Dr. Claire BoothGraduate University: University College London

125Dopamine receptor independent modulation of nucleus accumbens medium spiny neurons by dopamineDennis A. Burke, Veronica A. AlvarezGraduate Student Name: Dennis A. BurkeNIH Institute-Center: NIAAANIH Research Advisor: Dr. Veronica A. AlvarezGraduate University: Brown University

127Ultrasound treatment ameliorates DSS-induced ulcerative colitisNatalia S. Nunes, Scott S. Burks, Ana H. Paz, Joseph A. FrankGraduate Student Name: Natalia S. NunesNIH Institute-Center: CCNIH Research Advisor: Dr. Joseph A. FrankUniversity Research Advisor: Dr. Ana H. PazGraduate University: Universidade Federal do Rio Grande do Sul

129Systemic messenger RNA (mRNA) therapy delivered via lipid nanoparticle as a treatment for MUT class methylmalonic acidemia (MMA)Jessica L. Schneller, Jeff An, Andrea Frassetto, Shi Liang, Xuling Zhu, Ji-Sun Park, Sue-Jean Hong, Jenny Zhuo, Raj Rajendran, Vladimir Presnyak, Staci Sabnis, Christine Lukacs, Lin Guey, Paolo Martini, Randy J. Chandler, and Charles P. VendittiGraduate Student Name: Jessica L. SchnellerNIH Institute-Center: NHGRINIH Research Advisor: Dr. Charles P. VendittiGraduate University: SUNY Stony Brook

131Importance of left dorsolateral prefrontal cortex in moral judgment using functional near-infrared spectroscopyHadis Dashtestani, Fatima Chowdhry, Milton Halem, Amir GandjbakhcheGraduate Student Name: Hadis DashtestaniNIH Institute-Center: NICHDNIH Research Advisor: Dr. Amir GandjbakhcheUniversity Research Advisor: Dr. Milton HalemGraduate University: University of Maryland, Baltimore County

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NOTES

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