1.900 new children affected each day by AIDS, that is 1 child every 20 seconds

dedicated to Global solidarity

20% deaths among children in Africa due to malaria,

a disease which can be cured…

Near 2 billion people affected by tuberculosis, that is one third of the world population

UNITAID sets up programs for HIV / AIDSmalariatuberculosis

A Global State of Emergency…

Medicines are in the North, patients in the South

The less developed countries represent:

84% of the world population

less than11% of the global health expenditure

more than 93% of the global disease burden

2.1 million HIV positive children in the world

660,000 children need ARV Only 40,000 benefit from it

Drug resistance is increasing Only 8% of pregnant women get ARV to prevent transmission of the disease to their baby

1st cause of child mortality for a disease that can be cured The disease burden is growing

ACTs are the most efficient treatment against growing drug resistances (efficient for 95% cases)

2 million people die from tuberculosis each year

1st cause of mortality for people with Aids

Drug resistance is growing Multi drug resistant treatments are extremely expensive (4.000 $/year)

Official signature of the five founder countries when UNITAID was launched, on 19 September 2006, United Nations, New York

27 donor countries already joined UNITAID

Guinea has just joined on 30th August 2007

Countries that implemented the air tickets levy

Tax already in place or now been implemented:

- France- Chile- Norway (tax on CO2 from airplanes)- Côte d’Ivoire- Congo - Guinea Conakry - South Korea- Madagascar - Mauritius - Namibia- Niger

Countries which have committed to implement the tax: Benin, Burkina Faso, Cameroon, Gabon, Liberia, Mali, Morocco, Central African Republic, Senegal,Sao Tome & Principe, Togo

UNITAID EXPECTED REVENUES 2006-2009

2007 2008 2009

Brazil 10,000 10,000 10,000Chile (1) 6,049 3,500 3,500France (1) 212,598 215,054 215,054Norway (1) 21,625 22,000 22,000UK 26,490 40,323 69,893

Spain 20,161 20,000 20,000New donors* (1) 10,000 80,000 150,000

------------- ------------- -------------318,023 390,876 490,446

% of airtickets levy or alike 84% 90% 90%

(1) airtickets levy or alike (CO2)

( '000 $ US)

* includes Korea (15 M$) Cote d’Ivoire, Congo, Madagascar, Mauritius, Guinea Conakry and Niger (tax already adopted) and 17 other countries where the tax is being implemented

The Gates foundation will also bring 10 M$ per year

More than 80% of UNITAID revenue is based on the air ticket levy

Impact of the air tickets levy: an example

Tax received on each ticket by

UNITAID (in France)

Economy classFirst class or

business

Flight in France or in

Europe

1 € 10 €

International flight

4 € 40 €

An aircraft with 300 passengers on board leaving from Paris will cover the treatment for 1 person with multi drug resistant tuberculosis, which is very expensive (approx. 4.000 $)

Antimalarial treatment for 2 children

1 HIV-positive childunder treatment

for 1 year

ex: flight Paris - Berlin

ex: flight Paris - Dakar

Furthermore… no economic impact on air traffic

1/ Improve access to treatment for HIV/AIDS, TB, malaria in developing countries

2/ Get lower prices for quality drugs and diagnostics

3/ Speed up products availability

Predictable long-term funding A budget over $ 300 million in 2007, 90% being already committed Price reductions as a result of larger volumes (pool procurement) 85% of funds for the poorest countries A small secretariat hosted by WHO: no bureaucracy

UNITAID objectives

UNITAID use of funds allows to:

1/ have manufactured drugs better adapted to patient needs (fix dose combinations)

2/ reduce prices: more drugs available for the same budget

3/ contribute to a better quality (pre qualification of drugs, incentive for manufacturers to invest)

4/ rapidly deliver drugs in the countries in need

UNITAID added value

UNITAID uses a wide range of tools to help reduce prices and accelerateavailability of drugs

Pool procurement

Prequalification

COST plus pricingPredictable funding

Encouraging market competition

Lowering barriers to entry on market

Market dynamics forecastVolume price negotiation

Partnership pricing

Encouraging technology sharing

Supporting local registration

Encouraging/attracting new manufacturers

Information sharing

Reference price / price ceiling

UNITAID works together with well-recognized partners :

A unique partnership model

In the last months, UNITAID

has committed to funding projects

against the three diseases…

I/ Pediatric ARV: Have 100,000 new HIV-positive children under adapted ARV treatments in 2007 (today only 40,000 are covered when 660,000 need it) in 40 countries.

II/ 2nd line ARV: reduce prices for 7 products and provide treatments for 60,000 new patients in 27 countries in 2007.

III/ Prevention of mother to child transmission: improve the care, reduce diagnostic prices, have 1.2 million pregnant women tested and 340,000 under ARV treatment in 8 countries in 2007-2008.

Ongoing UNITAID programsHIV / AIDS

Partner: the Clinton Foundation

Partners: WHO and UNICEF

53 recipient countries from UNITAID fundsagainst HIV / AIDS

AFROAngolaBenin

BotswanaBurkina Faso

BurundiCameroon

ChadDRC

Cote d'IvoireEthiopiaGhanaGuineaKenya

LesothoLiberiaMalawi

MaliMozambique

NamibiaNigeriaRwandaSenegal

South AfricaSwazilandTanzania

TogoUgandaZambia

Zimbabwe

SEAROIndia

Thailand

WPROCambodia

ChinaLao

Papua New GuineaVietnam

AMRODominican Rep.

GuyanaHaiti

JamaicaOECS

(Anguilla, Dominica, St Lucia,

Antigua & Barbuda, Grenada,

St Christopher & Nevis, British Virgin Islands,

Montserrat, St Vincent & Grenadines)

EUROMoldovaSerbia

EMRODjiboutiMoroccoTunisia

I/ ACT scale up: Scale up ACT treatments in eleven countries, until 2010, for 55 million treatments, in order to have an impact on prices, give an incentive to manufacturers, avoid stock out in countries.

II/ ACT program in Liberia and Burundi : Provide nearly 1.3 million treatments in these two countries that had no coverage for 2007, before other donors stepped in.

Ongoing UNITAID programsMalaria

Partners: The Global Fund and UNICEF

Partners: WHO and UNICEF

22 recipient countries from UNITAID fundsagainst malaria

AFROBurundi

Cote d'IvoireEritrea

EthiopiaGambiaGhanaGuinea

Guinea BissauLiberia

MadagascarMali

MauritaniaMozambique

NamibiaSomaliaZambia

EMRODjiboutiSudan

SEAROBangladeshIndonesia

WPROCambodia

China

I/ 1st line TB : Support the transitional provision of 740,000 treatments in 2007-2008 for 18 countries and establish a strategic rotating stockpile.

II/ Pediatric TB: provide treatments adapted to children in order to treat

150,000 children by the end of 2007.

III/ Multi drug resistant TB : Support the purchase of 4,700 treatments

in 2007 for 17 low income and lower middle income countries, with a

view to decreasing prices.

Partner: The Global Drug Facility

Partners: The Global Drug Facility and the Global Fund

Partners: WHO and UNICEF

Ongoing UNITAID programsTuberculosis

58 recipient countries from UNITAID fundsagainst tuberculosis

AFROBenin

Burkina FasoCape VerdeCameroon

Congo BrazzavilleDRC

Cote d'IvoireThe Gambia

GuineaKenya

LesothoMadagascar

MalawiMali

MauritaniaMozambique

NigerNigeriaRwandaSomaliaTanzania

TogoUgandaZambia

SEAROBangladesh

BhutanIndia

IndonesiaMyanmar

NepalSri Lanka

Timor-Leste

EUROAzerbaijan

Bosnia-HerzegovinaBelarusBulgariaGeorgia

KyrgyzstanKazakhstan

MoldovaTajikistan

Uzbekistan

EMROAfghanistan

DjiboutiEgyptIraq

LebanonPakistan

Syrian Arab Rep.Yemen

WPROCambodia

LaoPhilippines

Vietnam

AMRODominican Rep.

Guatemala Haiti

Facing a global state of emergency, UNITAID contributes to bring solutions

In less than a year, UNITAID has

already achieved major results…

1/ First significant price reductions

30 November 2006 on antiretroviral

for HIV positive children(with the Clinton foundation)

8 May 2007 on second-lineantiretroviral

(with the Clinton foundation)-27%

-23%

-32%-40

-30

-20

-10

0

10

20

30

ABACAVIR 300mg TENOFOVIR 300 mg TENOFOVIR 300mg/ LAMIVUDINE300mg

-39%

-57%

-26%-29%

-33%-29%

-60

-50

-40

-30

-20

-10

0

10

20

30

40

TDF TDF+3TC TDF+FTC ddl ABC LPV/r

"My long experience in public policy taught me that even those who don't like taxes are not reluctant to pay a contribution for a good

cause.

Thanks to UNITAID, we succeeded to lower the annual cost of a treatment for a child

with AIDS from 196 $ to 60 $. Each citizen who gets into an plane and pays its

contribution should reflects on that : with the same amount of money, we save three time

more children.."

President Bill Clinton Le Monde – 25th July 2007

UNITAID first results

2/ More user-friendly drugs

With UNITAID funding, new treatments put on the market against HIV/AIDS are more adapted :

- Doses well adapted to children corpulence

- Drugs to be taken in the form of tablets (fix dose combination) : 1 tablet replaces several doses daily

- Heat stable drugs : no refrigeration needed anymore

- No need to dilute them in water (problem of access to drinkable water in some countries).

Pediatric DFC make easier HIV/AIDS treatment, for patients but also for healthcare professionals.

Daily treatment for a patient

0

10

20

30

40

50

60

70

80

90

100

Nov '06 Dec '06 Jan '07 Feb '07 Mar '07 Apr '07 May '07 TO DATE

Number of children under treatment (31st May 2007)

(000’s)

40,758 children already under

treatment

28,229 new children

TOTAL

3/ The first drugs already in the field… against HIV/AIDS

Pediatric ARV program with the Clinton foundation

Source: Clinton foundation

Atter 3 months After 5 monthsOn admission

Jennifer

Source: Partners In Health / Clinton foundation

Results obtained: Impact for a patient

Pediatric ARV program with the Clinton foundation

Arrival on 12th June 2007 of 670,000 ACT doses in Liberia that will help to prevent the death of 6,800 children per year(partners: UNICEF / WHO)

Against malaria