1.bruton's disease

Upload: cherryjuliejane-rosales-caperida

Post on 06-Apr-2018

218 views

Category:

Documents


0 download

TRANSCRIPT

  • 8/3/2019 1.Bruton's Disease

    1/22

    &

    7:943880,80

  • 8/3/2019 1.Bruton's Disease

    2/22

    30/,22,4-:302,

    %0-,8./010.9330/,22,4-:302, 8,

    1,:7041254.90570.:78478942,9:70394

    254.908,3/:92,905,82,.08$3.090,.

    90

    .0

    89

    ,9,70

    70

    85438-0

    147574/:.322:344-:38

    7:9438 ,,2,4-:302, 4730/,,22,4-:302, 8

    5708039,9-79.43039,,3/8.,7,.9070/-447.425090

    ,-80390;084122:344-:38 390-44/8970,222:344-:38 ,70

    574903240.:083-44/807:29,91:3.9430,39-4/0894:9

    90290-4/,.8,1:1:3.943322:3088902!0784389

    ,70;:307,-0947050,90/549039,1,9,-,.907,310.9438

    8.,:80/-,/010.93900309,9.4/081479%8/010.90,/8

    94-4.0/2,9:7,94341.0890.089,9574/:.022:344-:380.,:8049075479438419022:308890281:3.943,504509

  • 8/3/2019 1.Bruton's Disease

    3/22

    0139434190728

    254.90 ,254.90/07;0/1742-4302,7749,9574;/08:247, 22:399

    70.43081700,3903240.:08384:943,3/2,9:7083945,82,.089,980.7090

    22:344-:3,39-4/089,93,.9;,9090,39038

    570.:7847.0,545:,94341.08390-4302,7749,9,703.,5,-0418017030,90,70

    /07;0/174257403947.08,3/,70901789.0841,5,79.:,7-44/.0309,9.,3-070.430//:094907850.1.247544..,7,.90789.8057407974-,89

    254/!70.:784708 254.9057403947.089,9,7070897.90/3907/1107039,943

    549039,9490254.9030,0%0574.089,041!%/0;0452039570.0/08

    90570.089,008 17429089,041!%/0;0452039070'

    ###%8.425090/%0570.089,08570.0/0/-90574.0

    89,008 17429089,041!%/0;0452039070###%-038%0574.089,081440/-90570.089,0

  • 8/3/2019 1.Bruton's Disease

    4/22

    97:9438 ,,22,4-:302, 9748303,80 9 8,

    .945,82. 9748303,80 25479,393254.90/0;0452039

    /1107039,943,3/83,39 8,202-074190%0.1,241

    3,808:9,94383909 0300,/9430/,,22,4-:302, 3:2,38,3/30/

    22:34/01.03./32.0

  • 8/3/2019 1.Bruton's Disease

    5/22

    !,945844

    390,-803.041%254.908/4349/1107039,90472,9:7094:92,9:70

    254.908,39-4/574/:.35,82,.08,70,84,-80398,.43806:03.0

    90709.:403/490, ,3/254/47,383.9080.08574107,90/1107039,90,3/,7089470/,705447/0;0450/%085003909438890

    ,/034/890!007 5,9.0839039089308,3/90507507,2534/082,,

    -070/:.0/38047,-803933/;/:,8930/,,22,4-:302,

  • 8/3/2019 1.Bruton's Disease

    6/22

    070/9!,99073417:9438 80,80

  • 8/3/2019 1.Bruton's Disease

    7/22

    4302,774

    !:7549039, $9020

    254/$9020

    !702,9:70.0

    ,9:70.0

    ,-8039

    7:9438 %74830

    3,80 0320

    9

    7:9438 80,8030/,22,4-:302,

  • 8/3/2019 1.Bruton's Disease

    8/22

  • 8/3/2019 1.Bruton's Disease

    9/22

    ,n

    fff

    %ff

    nOn

    %O

    nf %

    f

    nffn

    nfn

    # f

    n

    n

    f

    n

    fn@

    -f

    ,nf

    $

    f

    9f

    $902.097,385,39,943

    425.,9438

  • 8/3/2019 1.Bruton's Disease

    10/22

    # f

    fn

    ,f

    n,

    n

    n

    nf

    n

    fffn

    fn

    n9f

    f

    9nf

    ff

    nf

    f

    9nfn

    9f

  • 8/3/2019 1.Bruton's Disease

    11/22

    ,3489.%089

    4743.'8,253 ,574.0/:704-9,33,5703,9,0;,:,943/,9,

    0,73,5703,3.-9/7,3,.4743.;8,2501742109,

    202-7,308

    234.039088 ,34-89097.574.0/:703.,82,,24:3941,2349.1:/87024;0/147,-47,947,3,8898:8:,50714720/

    -090039089003,3/90390900841089,94394,/390

    /,3488411,9,,-3472,908

  • 8/3/2019 1.Bruton's Disease

    12/22

    ,-47,947$9:/08

    !07147239,89:/0820,8:736:,399,9;022:344-:3,3/22:344-:3

    0;08 0;0884:/-020,8:70/1789570107,-,1907,024398032,9073,0;08

    /0.30 0;08-042/ ,70:8:,3/.,9;04130/,,22,4-:302,

    %0/090.94341,3/ 0;08870,90/94,0%5., ,3/ ,70

    :3/090.9,-00;08,7070/:.0/32,0890850.1.7010703.07,30;,:08,70

    ,;,,-094.425,709905,903980;0

    3.0,39-4/0;08,70/090.90/,8,-3472,4.43172,9438,99,30/-:831:474.942097.

    ,3,8841254.90,3/%254.902,7078 .00;084079,32/ ,70

    /,3489.4131:474.942097. ,3,88%.0;,:08 ,3/,70:8:,3.70,80/

    :7907,3,88.,3-02,/0-/090.93 70854380894%.0/0503/039,3/%.03/0503/039

    ,39038-,/238907322:3,94388:.,8,3:3.43:,90/ ;,039530:24.4..,;,..30%

    .03/0503/03970854380847909,3:8/5907,,3/31:03,0950 -22:3,943%.0

    /0503/039708543808

  • 8/3/2019 1.Bruton's Disease

    13/22

    2,3$9:/08

    0,/7,/47,582,/0243897,90,3,-803.0419438847,/034/8:79072,389:/084190

    .089.,3/0243897,90.743.310.9438478345:243,7 /80,80

    !:243,71:3.94390898,70.0397,942439473:3/80,8041-49904-897:.9;0950,3/90

    70897.9;0950%084:/-0.0.0/0,73./7034.,3507147290908995.,,0

    !74.0/:708

    3/48.45,3/.44348.45.,3-0:80/94,880889009039,3/905747088434131,22,947-40

    /80,80743.48.45 .,3-0:801:3/,3483,3/97,.3.743.:3/80,80,3/310.9438

    8944. 3/38

    35,90398930/,,22,4-:302, 254/988:08,.0723,.039078,3/

    5,82,.08,702883174290,23,57457, 4190:9,3/1742-4302,7748947083988:0

    8,25089,03940;,:,90310.943902489.4224313/38,339038031,22,94770854380

  • 8/3/2019 1.Bruton's Disease

    14/22

    %70,920398

    31:8434122:344-:3' 94,7/411310.943

    %02489.42243970,920391478,3 397,;034:8 31:843

    41 22:344-:3 ':2,3 ,39-4/080;0700814710'8

    ,:2,3574/:.9097,.90/,3/5440/174294:8,3/841 -44/ /43,9438'/408349.:70-:93.70,808905,903981085,3,3/6:,94110-

    0307,93 5,88;022:39,3/-4489390 22:3088902

  • 8/3/2019 1.Bruton's Disease

    15/22

    39-49.894970,9310.943,8904..:7

    %080,0398970,9.422438345:243,7 310.94380530:243,

    4998 20/,7:88:.,8,24.3 ,3/,24.3.,;:,3,90 ,70

    95.,,0398:80/:4746:34430 907,58:801:147 70857,947

    89,54.4.., 310.9438 ,3/1475,90398 9,0708 944907 20/.,9438 1

    90310.9438.,:80/ - .45,82, 47,382890/7:

    41.4.08.,79742.3 $0;070310.94382,706:704859,,943

    ,3/'907,59 .0197,430 47;,3.42.3

    $902.097,385,39,9438,.4.0

    14790970,92039417:943 /80,80

  • 8/3/2019 1.Bruton's Disease

    16/22

    !70;03943

    ,2089,3432:9,90/030.,3-05703,9,0;,:,90/94-099075705,70

    1479031,398.,70%0893850714720/;,,234.03908847.4743.;

    8,2531907-7990893850714720/43.47/-44/

    !,9039/:.,943

    !,90398,3/9071,2082:89:3/0789,3/903,9:704190/80,80,3/90

    25479,3.0410,7970,92039/0391.,943,3/970,9203941.42243310.9438,70

    30.088,7147,-099075743488

    0309..4:3803870.42203/0/147905,70398,3/102,08-38412,08

    4,70,110.90/40.:,7.,7,.907,943,3/.,7707/090.943831472,9;03

    411,208!703,9,/,34888,;,,-0

  • 8/3/2019 1.Bruton's Disease

    17/22

    ,3,02039

    $:55479;0

    2:9/8.53,7,5574,.

    !,0/,97.8 243907147310.9438970,99,39;7,

    ,0398,3/,39-49.8,:9422:30/80,808,3/2,3,3.08

    0309.8 0309..4:38035703,9,/,34889$,8574-0

    5745,.9.,22,4-:3

    '397,90.,

    5745,.9.,39-49.8

    ,;4/22:3,9439,9903:,90/;0;7,;,..308

    430,774%7,385,39,943

  • 8/3/2019 1.Bruton's Disease

    18/22

    :783,3488

    #8147310.943

    30110.9;07,0,7,3.0

    25,70/,8.,30

    .:90!,3

    #814725,70/$339079

    #8147$570,/41310.943

    89:7-0/$03847!07.05943,:/947

    89:7-0/$03847!07.0594341,.947

    25,70/421479

  • 8/3/2019 1.Bruton's Disease

    19/22

    ,908908,-4:9

    43,8932024770893,3/202470110.947 %.083:2,330/

    ,,22,4-:302,

    431.93708:984-9,30/1742,32,89:/088:0899,9.085,,74032,39,3343

    9072%.020247,3/3803%.07085438094,7/,%0507%503495030/

    ,,22,4-:302, 8,0309.:2,3/80,80.,7,.9070/-90,.41.7.:,93.08

    /:094902:9,943417:943 9748303,80%8/80,809:87057080398,:36:024/014789:/3

    9074041254.908370:,93%.01:3.94383:2,38%498,20,3,0/05,998

    03;0450,390303;850.1.%.0202473,80708415,90398;,..,3,90/ ,,389

    05,998;7:8'

  • 8/3/2019 1.Bruton's Disease

    20/22

    014:3/03;850.1.%254.908574/:.3390710743,22,39070:347-49390

    507507,-44/415,90398:594,90,8924398,1907.4250939089,3/,7/,39'

    22:3,94357494.4%003;850.1.%.01706:03.08,3/90507.039,0415,903989

    9080708543808070349831.,39/110703917420,9;,..3,90/.439748.42-33.0

    5:71.,943,3/032030/22:348549 ,88,014:3/9,90110.947 %.08.

    574259574/:.0/.9430837085438094,3903,3/2024770893%.08.

    706:70/70892:,943 9450714729071:3.94380702,39,30/3-495,90398,3/

    .439748147:59424398,190790,89;,..3,943-4489

    %080/,9,897438:0899,9.08,70349,3,-84:90706:702039147900307,943410110.9;0

    %.0202473:2,38347/49080029431:03.0%%-,,3.0

    !,74 ..,50,94 7,3.,;, '38,,.4 !0-,3 ,8,34 ,73,-, '

    44/

    ,7

  • 8/3/2019 1.Bruton's Disease

    21/22

    #010703.0

    3%7:943 ,22,4-:3,02,00/.30$059

    072,808 #0-8907!72,754,22,4-:3,02,,8:7;041.3.,2,31089,9438,3/.425.,9438"0/,3,-897,.9(

    $:$025%70,920394154,22,4-:3,02, 9397,;034:8

    22:344-:37.8/:3,-897,.9(

    !,9458447/ /943,7-,7, 4:/

    07.,3:,

  • 8/3/2019 1.Bruton's Disease

    22/22

    %,34:14789033