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Page 1: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
Page 2: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple

1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders.

3.Diagnosis and workup for plasma cell disorders/Multiple Myeloma 4.Staging and prognosis

5.Treatment strategies 

Page 3: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
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Page 5: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
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Copyright ©2010 American Society of Haematology. Copyright restrictions may apply.

Ghobrial, I. M. et al. ASH-SAP 2010;2010:581-604

Table 20-1 Diagnostic criteria for monoclonal gammopathies

Page 14: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
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Risk of progression of MGUS to myeloma or related disorder using a risk-stratification model that incorporates the FLC ratio and the size and type of the serum monoclonal protein.

Rajkumar S V et al. Blood 2005;106:812-817

©2005 by American Society of Hematology

Page 19: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple

*Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications Blood 2010, Bianchi et al

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Page 25: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
Page 26: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
Page 27: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple

Copyright ©2010 American Society of Hematology. Copyright restrictions may apply.

Ghobrial, I. M. et al. ASH-SAP 2010;2010:581-604

Table 20-4 Staging systems for multiple myeloma: Durie-Salmon staging system and International Staging System (ISS)

Page 28: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple

Interaction between Plasma Cells and Bone Marrow in Multiple Myeloma.

Palumbo A, Anderson K. N Engl J Med 2011;364:1046-1060

Page 29: 1.Defining Plasma cell disorders/Multiple Myeloma 2.Identification of different plasma cell disorders. 3.Diagnosis and workup for plasma cell disorders/Multiple
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