2 forward looking statements · 3 skin cancer strikes 1 in 5 in the u.s. 1 it is the most common...
TRANSCRIPT
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This presentation contains certain forward-looking statements. These statements relate to future events or future performance and reflect management’s expectations and assumptions regarding growth, results of operations, performance and business prospects and opportunities. Such forward-looking statements reflect management’s current beliefs and are based on information currently available to management. A number of factors could cause actual events to differ materially. In evaluating these statements, prospective purchasers should specifically consider various risks as more fully outlined in the prospectus, a copy of which can be obtained online at www.sedar.com.
Forward Looking Statements
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� Skin cancer strikes 1 in 5 in the U.S.1
� It is the most common form of cancer
� 40-50% of Americans who live to 65 expected to get skin cancer 2
� Melanoma kills one person every hour in the US 3
� Melanoma is the #1 cancer killer of women 25-30 4
� Incidence of melanoma rising faster than any other cancer 5
� Melanoma accounts for 75% of skin cancer deaths 6
- Howard Rogers, Dermatologist, Lead on Medicare research
“There’s an epidemic of skin cancer”
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Which one of these lesions is melanoma?
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Early detection vital to saving lives
0
20
40
60
80
100 99% Melanoma Five Year Survival Rate by Tumor Stage 6
15%
Stage I Stage II Stage III Stage IV
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� 2 million Americans get skin cancer each year 7
� Treating melanoma alone costs $1.5 billion annually in the U.S. 8
� Advanced stage melanoma significantly more
costly to treat than early stage › Approximately $1,800 to treat early stage
melanoma, and $170,000+ to treat late stage melanoma
Early detection would save billions of dollars
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� Primary diagnosis done by GPs with varying levels of experience
� Full body examinations seldom conducted
� 33.8% sensitivity for melanoma for GPs 9 › Squamous Cell Carcinoma – 41.1% › Basal Cell Carcinoma – 63.9%
� Biopsies invasive and costly
› Permanent scarring
� ~80% of biopsies test negative 10
Current skin cancer detection methods limited
Clinical Diagnosis
Punch Biopsy
Histological Diagnosis
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� Detects melanoma with 99% sensitivity vs. 33.8% for primary clinical diagnosis 11
� Approved for sale in Canada, the EU, and Australia
� Winner of Popular Science “Best of What’s New 2011” award
� Developed by BC Cancer Agency and UBC
� Patented technology
� Exclusively licensed to Verisante Technology, Inc.
� Technology applied via endoscope to gastrointestinal, lung, and
cervical cancers
Initial Focus: skin cancer detection Breakthrough cancer detection system
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Skin cancer: Verisante AuraTM Highly automated detection process
te AuraTM
Near Infrared Raman Spectroscopy
Handheld probe scans for 21 spectral markers in an instant
Rapid speed enables full body scans
Provides data on chemical composition of skin based on molecular vibrations
Differentiates between malignant and benign tissue
Pathology on every lesion scanned
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Skin cancer: Verisante AuraTM Highly automated detection process
Safe, Non-invasive, Fast
Real time results 99% sensitive for all major skin cancers
Increased survival rates
Reduced treatment costs
Reduced unnecessary biopsies Reduced waiting times
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� 6 year clinical study at Vancouver General Hospital’s Skin Care Center
� Focused on differentiating cancerous lesions from benign lesions
� 1,000 skin lesions scanned
� Clinical study published in major peer reviewed journal Cancer Research
Skin cancer: Verisante AuraTM Proven in clinical trial by UBC Dept. of Dermatology
Melanoma
99% sensitivity 15% specificity 95% sensitivity 38% specificity
Cancerous and Precancerous Lesions
99% sensitivity 17% specificity 95% sensitivity 41% specificity
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Superior technology over competition
Verisante Aura™ Mela Sciences MelaFind™
Detects Melanoma, SCC, BCC, AK Detects Melanoma
NIR Raman Spectrometer Computerized Imaging Technology
Extensible platform technology No platform technology
Approved in Can, EU, Aus Approved in US, EU
99% Sensitivity; 17% Specificity 98% Sensitivity; 9.5% Specificity
1 second to scan lesion 2 minutes to scan lesion
Small probe Large probe
$10 disposable tip per patient $50 memory card per lesion
For use by all medical professionals For use by dermatologists only
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Skin cancer: Verisante AuraTM Clear regulatory pathway to commercialization
2012 2013 2014 2015
Sales Revenue
Sales Revenue
FDA Approval & Revenue
Production Engineering
Clinical Study PMA
Production Engineering
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Skin cancer: Verisante AuraTM Significant market potential with multiple end users
Canada
USA
EU
South Africa
Australia NZ
Initial Geographic Markets Recurring revenue from sale of disposable probe tips
Staged Rollout Strategy
STEP 1
Early adopters ~32,000 Dermatologists
STEP 2
Innovators ~950,000 General Practitioners
STEP 3
Skin Care Clinics Oncology and Imaging Clinics
HMOs
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Will drive broader market acceptance Initial focus on early adopters and innovators
0
400
800
1200
1600
2000
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
Targeting 14% penetration by year 5 Dermatologists
Canada, European Union, South Africa, Australia, New Zealand
United States
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Will drive broader market acceptance Initial focus on early adopters and innovators
General Practitioners
Canada, European Union, South Africa, Australia, New Zealand
United States
0
5000
10000
15000
20000
25000
30000
35000
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
Targeting 6% penetration by year 5
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� Clinical study underway at VGH for lung cancer detection › Pilot study results demonstrated remarkable
96% sensitivity and 91% specificity 12
› Technology named a “Top 10 Cancer
Breakthrough of 2011” by the Canadian Cancer Society
› Technology may also be applied to gastrointestinal and cervical cancers
Verisante CoreTM Endoscopic system enables detection of other cancers
Lung Cancer is the world’s #1 cancer killer with 1.4 million deaths/year 13
90%
1% 0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Early Stage Diagnosis Late Stage Diagnosis
Lung Cancer 5 Year Survival Rate: Early Stage vs Late Stage Diagnosis 14,15
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As of March 15, 2012 Share Capital
Common Shares 56,195,592
Escrowed Shares (held by Founders) 8,403,000
Total Common Shares Outstanding 64,598,592
Warrants 13,838,125
Incentive Stock Options 4,659,570
Fully Diluted Share Capital 83,096,287
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Market Comparables
Company Current Share Price
Est. 1yr Target Price Market Capitalization
MELA Sciences, Inc. (NASDAQ: MELA) $4.69 $12.80 $138,940,000
Novadaq (TSX: NDQ) $7.00 $6.56 $229,210,000
ALI Technologies Inc. *Sold to McKesson (NYSE: MCK) in 2002 for $530 Million
$530,000,000
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Dr. Branko Palcic Ph.D.
• Honorary Professor, Dept. of Pathology and Laboratory Medicine, UBC • Founder, Cancer Imaging and Technology Departments, BC Cancer Agency • Co-inventor of LIFE-Lung device, used in over 150 major medical centers world-wide • Friesen-Rygiel Award for Outstanding Canadian Academic Discovery (1999) • King George V Silver Jubilee Cancer Research Fellow
Dr. Haishan Zeng Ph.D.
• Senior Scientist, Integrative Oncology Dept. BC Cancer Agency • Associate Professor, Dermatology and Skin Science, University of British Columbia • Co-inventor - Verisante™ technology
Focused on developing systems for the early detection of cancer Strong scientific pedigree
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Dr. David McLean MD, FRCPC
• Professor, Dept. of Dermatology and Skin Science, UBC • President, Cancer Prevention Institute of Canada • Secretary-General, International Foundation for Dermatology • Former President, Current Board member, International League of Dermatological Societies • Former President, Canadian Dermatology Association • Co-inventor - Verisante™ technology
Dr. Harvey Lui MD, FRCPC
• Professor and Head, Dept. of Dermatology and Skin Science, UBC • Former Clinical Fellow, Massachusetts General Hospital, Harvard Medical School • University Killam Prize (2001) • Secretary-General, World Congress of Dermatology • Co-inventor - Verisante™ technology
Focused on developing systems for the detection of cancer Strong scientific pedigree
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Thomas Braun BA, JD, LLM – Chief Executive Officer
• Public company experience • Extensive experience in executing M&As and raising capital • Advised high tech companies on international business transactions • Expertise in technology licensing • Member, California Bar Association and Law Society of British Columbia
Anna Trinh B.Comm, LLB – Chief Financial Officer and Corporate Counsel
• Experience in counseling companies on regulatory and compliance filings • M&A and financial transaction experience • Practiced corporate securities law in private practice • Member, Law Society of British Columbia
Focus: controlling costs, accelerating product development & regulatory approval process
Experienced management
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Strong, independent Board of Directors
Joe Biegel BS, MS (Medical Imaging)
• Vice-President, Product Management & Marketing • McKesson Medical Imaging Group • Senior positions with Agfa Healthcare, Hewlett
Packard, Polaroid Medical Imaging
Chris Dennis MBA
• President and CEO, Novadent Inc. • Senior positions with Angiotech
Pharmaceuticals, Johnson & Johnson / Ortho Neutrogena
Jake Thiessen Ph.D.
• Professor Emeritus, University of Toronto • Founding Director, School of Pharmacy and
Health Sciences Campus, University of Waterloo
Karen Boodram BSc, MBA
• President, BioManna Consulting • Former Life Sciences Analyst, PI Financial • More than 25 years healthcare experience • Ten years with Novartis
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� Patented technology with exclusive worldwide license from BC Cancer Agency
� AuraTM: a breakthrough skin cancer detection device › Approved for sale in Canada, 27 member EU Nations, and Australia › FDA approval process started January 2012 › Featured as a top technology innovation in Popular Science’s “Best of What’s New” (2011)
� Clear regulatory pathway to commercialization with significant market potential
� CoreTM endoscopic device for detection of lung cancer in clinical trials › Recognized by the Canadian Cancer Society as a “Top 10 Cancer Breakthrough of 2011”
� Strong scientific pedigree and experienced management
� Verisante Technology, Inc. named 2012’s top ranking Technology and Life Sciences Company on the TSX Venture 50
Summary
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References End Notes
1. American Cancer Society: Cancer Facts & Figures 2009
2. National Cancer Institute: Cancer Trends Progress Report 2007, Update April 2008
3. American Cancer Society: Cancer Facts and Figures 2009
4. Melanoma Research Foundation
5. National Cancer Institute: SEER Cancer Statistics Review, 1975-2004
6. National Center for Chronic Disease Prevention and Health Promotion
7. Rogers H.W., Weinstock M.A., et al.: Incidence Estimate of Non Melanoma Skin Cancer in the U.S., 2006. Archives of Dermatology 2010
8. National Cancer Institute: Cancer Trends Progress Report 2007
9. Heal C.F., Raasch B.A., Buettner P.G., Weeden D.: Accuracy of Clinical Diagnosis of Skin Lesions. British Journal of Dermatology 2009
10. Jones T.P., Boiko P.E., Piepkorn M.W.: Skin biopsy indications in primary care practice: a population-based study. JABFP 1996; 9:397–404
11. Lui H., Zhao J., McLean D.I., Zeng H.: Real-time Raman spectroscopy for in vivo skin cancer diagnosis. Cancer Research Published
OnlineFirst March 20, 2012
12. Short M., Lam S., McWilliams A., Ionescu D., Zeng H.,: Using Laser Raman Spectroscopy to Reduce False Positives of
Autofluorescence Bronchoscopies, A Pilot Study. Journal of Thoracic Oncology 2011;6: 1206–1214
13. Cancer Research UK
14. Lung Carcinoma: Tumors of the Lungs. Merck Manual Professional Edition, Online edition. Retrieved 2007-08-15.
15. Ishida T, Inoue T, Sugio K, Inoue K, Inuzuka S, Tateishi M, Sugimachi K.: Early squamous lung cancer and longer survival rates
Contact: #306 – 2309 West 41st Ave Vancouver, BC V6M 2A3 Tel 604.605.0507 Fax 604.605.0508 Email [email protected] www.verisante.com TSX-V: VRS OTCQX: VRSEF FRANKFURT: V3T