2004 all hands meeting welcome to the birn all hands meeting
TRANSCRIPT
2004 All Hands Meeting
Welcome to the BIRN All Hands Meeting
Welcome
Thanks to • BIRN-CC, • Local organizers from MGH • The Crossover Working Group
Welcome
NCRR• Mike Marron• Anthony Hayward
BIRN-CC• Mark Ellisman
Testbed PI introductions
Why are we here?
BIRN-CC: Central infrastructure Mouse BIRN: Animal models of human disease BIRN-CC and Mouse BIRN reports this morning
Function and Morphometry BIRN: Human diseases• Alzheimer’s Disease• Schizophrenia
Alzheimer’s Disease Affects a third of those over age 75 Progressive degenerative illness Loss of memory, ability to plan and
think Loss of activities of daily living and
develop troublesome behavior leading to institutionalization
Third most expensive illness A family illness with enormous
economic and social costs
AP = amyloid plaques; NFT = neurofibrillary tangles; Slide courtesy of: George Grossberg, M.D.; St. Louis University
Neuropathological ChangesNeuropathological ChangesCharacteristic of ADCharacteristic of AD
Normal
AP
AD
NFT
Impact of delaying onset of Alzheimer’s disease in USA
Adapted from: Brookmeyer R et al. Am J Public Health. 1998; 88: 1337–42
16
Delay (years)
12
8
4
0205220422032202220122002
0
1
5
Pre
vale
nc
e A
D
(millio
ns
)
AD = Alzheimer’s disease
Course of aging: MCI & ADCourse of aging: MCI & AD
AAMI
MCI
Clinical AD
Time (years)
Co
gn
itiv
e d
eclin
e ‘Brain’AD
Brain ageing Mild
Moderate
Moderately severe
Severe
AAMI = age-associated memory impairment; MCI = mild cognitive impairment
Distinguish other diagnoses
30 Nondemented Subjects with ApoE4 or E3 Allele
ApoE4 Genotype and Brain ApoE4 Genotype and Brain Activation Activation
Ch
a ng
e i n
Sig
na l
In
ten
s it y
(%
)
Trial Number
1.6
-0.46
-0.20.00.20.40.60.81.01.21.4
54321
ApoE4
ApoE3
Bookheimer SY,, et al. N Engl J Med. 2000(Aug 17);343(7):450-456
The Development of SchizophreniaThe Development of Schizophrenia
Sheitman BB, Lieberman JA. J Psychiatr Res. 1998(May-Aug);32(3-4):143-150
Age (Years)
Good
Function
Poor15 20 30 40 50 60 70
Premorbid Progression StableRelapsing
Pro
dro
me
?Improving
•
Fir
st
Ep
isod
e
Working Memory in SchizophreniaWorking Memory in Schizophrenia
Sternberg task: Sternberg task: Five Five Two Two
5 6 2 8 1
+
8
+
3
Five items compared to Two
0 9
+
6
+
9
Genomics and Human Brain FunctionGenomics and Human Brain Function
Clinical and cognitive measures
NeuroimagingInheritedgenotype
DNA
-48-48 AA
3’3’5’5’--
3’3’5’5’-- -48-48
GG
DRD1
0.150.18
0.140.11
-0.14-0.10-0.06-0.020.020.060.100.140.180.220.260.30
ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
5 6 2 8 1
+
8
+
3
5 6 2 8 15 6 2 8 1
++
88
++
33
Why are we here?
A concerted effort is required To achieve more in synergy than as multiple
uninvolved efforts This is a new way to do science
• Is it a useful one?• Is the whole greater than the sum of its parts?
Infrastructure development
Data sharing is essential and requires infrastructure Terabytes of data are not amenable to ftp or mail Data has to be meaningfully combined to generate
new findings that would not otherwise be possible
Clinical Measures
GenotypeData
Local Storage
DU
P
HumanData
Protection
INSTITUTION A
BIRN Rack
SRBMCAT
HID
PortalMediator
Calibration& Analysis
Tools
GridFederation: distributed DB, autonomous, access integrated resourcesMediator: translates heterogeneous data sources to consistent representation
ImagingData
Infrastructure development
We need resources to support this scientific strategy• The Shared Resource Broker (SRB)• A federated database system• Intelligent queries of nonlocal, integrated data,etc
The resources we develop are applicable beyond the original testbed intentions• U54s, etc., MIND, TURNS, CATIE, NTROI, industry• GCRC interactions
A new way of studying diseases
Cooperation among top competitors• How to share, work, glory and $
• Who makes and keeps the rules
Integrative and synergistic
A new way of studying diseases
Multidisciplinary research: • Researchers working in parallel, in sequence, or jointly on
a common problem maintaining a discipline-specific basis.
Transdisciplinary: • Bridging several fields • Develop a shared conceptual framework formed by
integrating and synthesizing discipline-specific theories, and perspectives to address a common problem
• Such that the whole is more than the sum of its parts (Rosenfield, 1992).
A new way of studying diseases
This meeting is an invaluable opportunity to enrich your own research• Collaborating with top researchers around the
country and • Developing novel methods across disciplines
What can the other test bed tools, methods, and findings offer you?
What of your methods and findings might enhance their research?
Today: Testbed Discussions
BIRN-CC (9:30 am) Mouse BIRN (10:45 am)
Morph BIRN (1:45 pm) Function BIRN (2:45 pm)
0.150.18
0.140.11
-0.14-0.10-0.06-0.020.020.060.100.140.180.220.260.30
ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
Today: BIRN Development
New initiatives involving BIRN (4:15 -5:00)• Four NCRR U54 funded and two directly involve BIRN• Roadmap Exploratory Center for Imaging Genetics• ADNI, etc…
Cross-testbed interactions & coordination (5:00- 6:00)• Information sharing, exploration of cross-test beds syngery• Eg. Can Mouse use Morphometry’s Slicer?• Eg. How FBIRN use Mouse registration tools?
Tomorrow: Steering the BIRN Future
Genetics: Its promise and challenge
(8:30-10:00)
Task Force discussions: (10:30-3:30)• Other institutions, investigators want access to the data
and resources This challenges current data sharing methods and policies This requires clear IP and human subjects’ protections This has IT resource implications and demands
• Given our experiences so far: How do we enable this access?
• This is an All-BIRN issue: these decisions affect YOU
Tomorrow: Where do we go now?
Providing BIRN toolkit and data, aka: Do you know where your portal is? (3:30 – 4:30 pm)
• What are the resources and tools currently available, developed by BIRN-CC and all the test beds
• How do you use these tools now?• What are the current plans for future developments
Milestones for the next year (4:45 – 6:00 pm)
• How is the whole greater than the sum of the parts• Does this infrastructure being created allow discovery of
new, integrated findings based on the collaborative synergy of BIRN?
Also not to be missed
Executive Committee meetings • Noon-2 pm each day
FBIRN Image Processing Pipeline Working Group meeting • Noon Today in the Nantucket Room
Mediator hands-on demos • Noon Tomorrow in the Nantucket Room
FBIRN Statistics Discussion • Noon-3 pm Tomorrow in the Quincy Room