2004 fbirn meeting first birn: challenges of collaborative multi- site, multi-discipline research...
TRANSCRIPT
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2004 FBIRN Meeting
FIRST BIRN: Challenges of Collaborative Multi-site, Multi-discipline Research
Steven Potkin, MD
Gary Glover, PhD
Gregory McCarthy, PhD
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OutlineOutline
Why is this important Our vision Clinical Aims Challenges Accomplishments
Gary Glover: Calibration Experience
Gregory McCarthy: Cognitive Challenges
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Why Is This ImportantWhy Is This ImportantWhy Is This ImportantWhy Is This Important
Schizophrenia - • Cause unknown • No cure but treatable
Neuroimaging is critical to understanding• Gross structural and functional abnormalities
(e.g., frontal and temporal)
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Statistical Parametric MapStatistical Parametric MapMai et al Human Atlas, 2001Mai et al Human Atlas, 2001
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Why Is This ImportantWhy Is This Important
Research hampered by • Spatial distortions (Morph BIRN)• Inconsistent data & lack of replications• Noncomparable imaging techniques • Small and diverse patient populations
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Solution: Queryable Federated DatabasesSolution: Queryable Federated Databases
fMRI
Are chronic, but not first-onset patients, associated with Are chronic, but not first-onset patients, associated with superior temporal gyrus dysfunction (MMN)?superior temporal gyrus dysfunction (MMN)?
IntegratedIntegrated ViewView
Receptor Density ERP
WebWeb
PubMed, Expasy
Wrapper
WrapperWrapper
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Structure
Wrapper
Clinical
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MediatorMediator
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ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
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Functional Imaging Research Schizophrenia Testbed = First BIRN: Operational for 17 months
Builds on and extends the mouse BIRN and morphometry BIRN
Extend morphology BIRN technology• Into 4D (time)• During sensory and cognitive tasks• Tackle schizophrenia
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FIRST BIRN: Clinical AimsFIRST BIRN: Clinical Aims
Study brain functioning in schizophrenia with fMRI• Dorsolateral pre-frontal cortex (working memory)• Superior temporal gyrus (early cortical auditory
processing)• Site-specific cognitive tasks activating DLPFC
and STG.
Develop infrastructure to understand the development & progression of schizophrenia
Sensitive to alteration by treatment
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FBIRN: Patient PopulationsFBIRN: Patient Populations
Childhood schizophrenia Elderly onset First episode Chronic baseline and after treatment
• Atypical antipsychotic• Cognitive enhancers
Prodromal Normal healthy volunteers
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First BIRN SitesFirst BIRN Sites
• Brigham & Women’s
• Duke • Iowa • MGH • Minnesota • New Mexico
• UCI
• UCLA
• UCSD
• UNC
• Stanford
Experienced imaging sites
Well developed ideas on how imaging should be done
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Challenges: Creating a New CultureChallenges: Creating a New Culture
How to get competitors to cooperate• Will this project decrease the RO1 $ pool• How to share glory, work and $• Governance - who makes and keeps the rules
How to avoid “What’s mine is mine and what’s yours is mine” How to communicate across fields efficiently:
• Clinician scientists Computer scientists• Experimental psychologists MRI physicists• Statisticians Database engineers
How to show a clear scientific benefit from cooperation• Efficiency of multiple studies in parallel; quick revisions • Different perspectives create new ideas or achieve the lowest
common denominator “designed by committee”
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ChallengesChallenges
How to incorporate HIPAA regulations• Security - paperless/wireless & audit • Confidentiality & IRB - what do subject need to know
and agree to• Rules of upload and down. access to data
How to develop a new model for data sharing How to meet technological challenges:
• Space for storage• Tools for manipulation• Ability to transfer gigabytes of data around the country• Assume that soft and hardware changes are inevitable
How to show usefulness outside of BIRN
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Inter-site variabilityInter-site variability
Different scanners = different raw images
How bad it is?
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Inter-site variabilityInter-site variability
Different scanners = different raw images
How bad it is?
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A Unique Dataset: A Unique Dataset: Human Calibration SubjectsHuman Calibration Subjects
5 healthy, right handed males Between 18 and 40 years old College students or graduates Traveled around the country from late July
to mid September, 2003
100 scanning sessions: over 800 different scans
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Technology: HID GUITechnology: HID GUI
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Federated Imaging DatabasesFederated Imaging Databases
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Solution: Federated DatabaseSolution: Federated Database
fMRI
Are chronic, but not first-onset patients, associated with superior temporal gyrus dysfunction (MMN)?
Integrated View
Receptor Density ERP
Web
PubMed, Expasy
Wrapper
WrapperWrapper
Wrapper
Structure
Wrapper
Clinical
Wrapper
MediatorMediator
0.150.18
0.140.11
-0.14-0.10-0.06-0.020.020.060.100.140.180.220.260.30
ARIP - 20MG ARIP - 30MG RISP - 06MG PLACEBOTreatment Group
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Accomplishments: To Date
Common image translation method: XML Common Database Schema for fMRI: HID (not yet
federated) Queryable clinical and imaging database: GUI Initial phantom protocol and assessments: QA Initial human calibration study Analysis of same data with different methods Initial calibration methods for multi-site fMRI studies
These methods are: Flexible, Expandable, and Adaptable to other types of data and fields of study
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Major Accomplishments
Cultural change A new way to do science that is both
creative and exciting, and works• Willingness to have others analyze your
data with their methods
• To facilitate use of your methods on their data
• Sharing concepts as well as data
• Solving common problems –rapid turn around time, new perspectives
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Why are we here today?Why are we here today?
WE NEED FEEDBACK FROM YOU:
Which developments are useful for your projects?
Which developments are we missing?
How can we build better bridges to your projects?