2005 4-k o'connell c10 trial data final msd finca productiva salud del hato

EU COVEXIN 10 LAUNCH

TRIAL DATA

Protective Antitoxin Levels

Clostridia Protective levelof antibody

Pharmcopoeia or 9CFR listedpotency level

C. tetani 0.1 U/mL 2.5 U/mL or 2.0 U/mLC. novyi type B 0.1 – 0.4 U/mL 3.5 U/mL or 0.5 U/mLC. perfringens type A 0.1 U/mL NoneC. perfringens types B and C( beta toxin)

0.5 U/mL 10 U/mL

C. perfringens type D(epsilon toxin)

0.1 U/mL 5.0 U/mL or 2.0 U/mL

C. sordellii 0.1 – 0.2 U/mL 1.0 U/mLC. haemolyticum 20 – 40 U/mL NoneC. septicum 0.5 U/mL 2.5 U/mL

Table of Susceptibility for CattleClostridium Approximate Age of Susceptibility*

0 – 14 days 2 – 13 weeks 3 – 12 months 1 – 3 years >3 yearsC. perfringens type A + + + - -C. perfringens type B + + + - -C. perfringens type C + + + - -C. perfringens type D + + + + -C. septicum + + + + -C. chauvoei - - + + -C. novyi B - - + + +C. sordellii - - + + -C. haemolyticum - - - + +C. tetani + + + + +

Table of Susceptibility for Sheep

Clostridium Approximate Age of Susceptibility 0–14

days 2–4 weeks

4-12 weeks

3–6 months

6-12 months

1-3years >3 years

C. perfringens type A ++ + + C. perfringens type B ++ + + C. perfringens type C ++ + + + + C. perfringens type D ++ + ++ + + C. septicum ++ + + ++ ++ C. chauvoei + + ++ ++ ++ ++ ++ C. novyi B + ++ ++ C. sordellii ++ ++ + ++ + ++ C. haemolyticum ++ ++ C. tetani ++ ++ ++ ++ ++ ++ ++

VaccinateGroup

ControlGroup

MonitorGroup

Vaccinate2 weeks age Monitor

Vaccinate2 weeks age

Bleed 10 weeks Bleed 10 weeks Bleed 10 weeks

Boost 8 monthsBleed 1 week later



Last vaccination2 weeks prior toParturition

Results for C. tetani

0

5

10

15

20

25

30

Vaccinate Control Monitor

Ant

ibod

y Le

vel (

u/m

l)

Dams (V2 + 14)Calves (V1, 2 weeks of age)Calves (V2 + 14, 10 weeks of age)Calves (26 weeks post V2)Calves (27 weeks post V2)

Results for C. tetani

0

2

4

6

8

10

12

14


Antib

ody

Leve

l (u/

ml)

Dams Day 56 (V2 + 14)

Lambs Day 76 (V1, 2 weeks of age)

Lambs Day 132 (V2 + 14, 10 weeks of age)

Lambs Day 300 (26 weeks post V2)

Lambs Day 307 ( 27 weeks post V2)

Results for C. novyi type B

0

1

2

3

4

5

6

7

8


Ant

ibod

y Le

vel (

u/m

l)


Results for C. novyi type B

0

5

10

15

20

25


Antib

ody

Leve

l (u/

ml)

Dams Day 56 (V2 + 14)Lambs Day 76 (V1, 2 weeks of age)Lambs Day 132 (V2 + 14, 10 weeks of age)Lambs Day 300 (26 weeks post V2)Lambs Day 307 ( 27 weeks post V2)

Results for C. perfringens type A

0

0.5

1

1.5

2

2.5

3

3.5

4


Ant

ibod

yLev

el (u

/ml)


Results for C. perfringens type A

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6


Antib

odyL

evel

(u/m

l)


Results for C. perfringens type B/C

0

10

20

30

40

50

60

70


Ant

ibod

y Le

vel (

u/m

l)


Results for C. perfringens type B/C

0

10

20

30

40

50

60


Antib

ody

Leve

l (u/

ml)


Results for C. perfringens type D

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

5


Ant

ibod

y Le

vel (

u/m

l)


Results for C. perfringens type D

0

5

10

15

20

25

30

35

40


Antib

ody

Leve

l (u/

ml)


Results for C. septicum

0

2

4

6

8

10

12

14

16


Ant

ibod

y Le

vel (

u/m

l)


US Trial Data for US Trial Data for C. septicumC. septicum

Mean C. septicum ELISA Titers in Calves After Vaccination

00.05

0.10.150.2

0.25

0.30.35

Covexin 8 Vision 8 Controls

Tite

rs in

Cal

ves

at V

2 +1

4

Results for C. septicum

0

1

2

3

4

5

6

7

8

9


Antib

ody

Leve

l (u/

ml)


Results for C. sordellii

0

1

2

3

4

5

6


Ant

ibod

y Le

vel (

u/m

l)


Results for C. sordellii

0

2

4

6

8

10

12

14

16


Antib

ody

Leve

l (u/

ml)


Results for C. chauvoei

0

0.05

0.1

0.15

0.2

0.25

0.3

0.35

0.4

0.45

0.5


Ant

ibod

y Le

vel (

u/m

l)


Results for C. chauvoei

0

0.5

1

1.5

2

2.5

3

3.5

4


Antib

ody

Leve

l (u/

ml)


Results for C. haemolyticum

0

20

40

60

80

100

120

140


Ant

ibod

y Le

vel (

u/m

l)


Results for C. haemolyticum

0

10

20

30

40

50

60

70


Antib

ody

Leve

l (u/

ml)


2005 4-k o'connell c10 trial data final msd finca productiva salud del hato

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