2013 annual report v5 - mcgill university · research successes included 78 publications in high...

Department of Microbiology and Immunology: 2013 Annual Report

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McGILL UNIVERSITY

DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

2013 ANNUAL REPORT

Submitted by

J. Madrenas, MD, PhD, FCAHS Canada Research Chair in Human Immunology

Professor and Chairman

On behalf of the

Primary members of the Department of Microbiology and Immunology


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Section I Introduction


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A. Executive Summary

2013 was another great year for the Department of Microbiology and Immunology at McGill.

The department welcomed Dr. Selena Sagan, a virologist from Stanford University (and former graduate of our department!), who started as a tenure track assistant professor on August 1, 2013. Her arrival completes the 2nd recruitment in the context of departmental faculty renewal.

In Research, we completed the eestablishment of the Microbiome and Disease Tolerance Centre at McGill, a multi-disciplinary and trans-departmental Centre that involves 26 members from 3 universities. This centre was approved by the Board of Governors and started its operation on May 2013. A 2-day Retreat to outline research and strategy took place later.

Our members, including our new recruits, were very successful in obtaining external, peer-reviewed grants for over $10M from the most stringent sources (CIHR, NSERC, CFI, Grand Challenges Canada, etc.), including 3 multi-centre large funding awards. This is particularly exciting when considering the current highly competitive funding environment. In addition, our members continue to be competitive in external salary award programs (CRCs, CIHR, FRQS). Of special note are the induction of Dr. Greg Matlashewski to the Canadian Academy of Health Sciences and the awarding of the CIHR-CMAJ Top Canadian Achievements in Health Research Award to Dr. Mark Wainberg. Research successes included 78 publications in high profile journals and invited lectureships around the world.

In terms of Education, the department continued the process of undergraduate and graduate program redevelopment. This broad range initiative has already translated into an increase in MIMM course enrolment by 16% in the last 2 years. Program redevelopment is proceeding with the accommodation not only of new course but also with the implementation of novel educational strategies that aim at providing the best learning experience to our trainees. This effort would not be possible without the work of the academic and non-academic members of the department.

Our students and trainees continue to excel in national and international venues. Among the many examples provided below, let me single out the awarding of the GG Silver Medal to Daisy Ji. Furthermore, with the departmental success in fundraising (over $400K), we were able to establish the Steinman Summer Undergraduate Research Awards, and the Wares Family Post-doctoral Fellowship awards to support under-graduate and post-doctoral training in our department.

Finally, in terms of Service and Administration, the department embarked in the optimization of financial and human resources support through establishment of an Administrative Excellence Centre involving our department and the departments of Anatomy&Cell Biology and Biomedical Engineering.

The department has strengthened its national and international profile. Our members are present in panels and committees of federal and provincial institutions, and advise public agencies on issues related to public health and policy. We take a leading role and participate into the CIHR-funded Human Immunology Network, and are also committed to community outreach. We achieved a web-based departmental penetrance to top 5 departments of Microbiology and Immunology in the World. And we continue to proactively engage our community, local elementary schools and public at large.


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It is a true privilege and honor for me to submit the 2013 Departmental Annual Report documenting the excellence of the members of the Department of Microbiology and Immunology at McGill University. My sincere thanks to each and everyone of them for their help in putting together this report.

B. Faculty Listing

1. List of Faculty members with primary appointments in the Department

Professors Dr. Joaquin Madrenas (Chairman, 2011-present)

Dr. Albert Berghuis Dr. Robert Murgita Dr. James Coulton Dr. Martin Olivier Dr. Matthias Götte Dr. Mark Wainberg Dr. Greg Matlashewski Associate Professors Dr. Dalius Briedis Dr. Greg Marczynski Dr. Benoit Cousineau Dr. Ciriaco Piccirillo Dr. Sylvie Fournier Dr. Donald Sheppard Dr. Herve Le Moual Dr. Samantha Gruenheid Assistant Professors Dr. Jörg Fritz Dr. Connie Krawczyk Dr. Irah King Dr. Selena Sagan 2. List of Faculty with secondary appointments Associate Members Dr. Jack Antel (Department of Neurology, Montreal Neurological Institute) Dr. Amit Bar-Or (Department of Neurology, Montreal Neurological Institute) Dr. Marcel Behr (Division of Infectious Diseases and Medical Microbiology,

Montreal General Hospital) Dr. Miguel Burnier (Chair, Department of Ophthalmology, McGill University) Dr. Nicolas Cermakian (Department of Psychiatry, McGill University) Dr. Ines Colmegna (Department of Medicine, Royal Victoria Hospital) Dr. Andre Dascal (Senior Physician, Jewish General Hospital) Dr. Maziar Divangahi (Meakins-Christie Laboratories, McGill University) Dr. Philippe Gros (Rosalind and Morris Goodman Cancer Research Centre) Dr. Sabah Hussain (Critical Care Division, Royal Victoria Hospital) Dr. Armando Jardim (Institute of Parasitology, MacDonald Campus) Dr. Antonis Koromilas (Department of Oncology, Lady Davis Institute for Medical

Research)


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Dr. Arnold Kristof (Critical Care Division, Royal Victoria Hospital) Dr. Richard Lalonde (McGill AIDS Centre) Dr. Chen Liang (Lady Davis Institute for Medical Research) Dr. Rongtuan Lin (Lady Davis Institute for Medical Research) Dr. Vivian Loo (Department of Medicine, Division of Infectious Diseases, Montreal

General Hospital) Dr. Andrew Mouland (HIV-1 RNA Trafficking Laboratory, Lady Davis Institute for

Medical Research) Dr. Momar Ndao (Department of Medicine, Division of Infectious Disease) Dr. Marianna Newkirk (Division of Rheumatology, Montreal General Hospital) Dr. Dao Nguyen (Department of Medicine, Montreal General Hospital Research

Institute) Dr. Kostas Pantopoulos (Lady Davis Institute, Jewish General Hospital) Dr. Joyce Rauch (Department of Rheumatology, Montreal General Hospital) Dr. Michael Reed (Medicine, Infectious Diseases, Montreal General Hospital) Dr. Petra Rohrbach (Institute of Parasitology, MacDonald Campus) Dr. Maya Saleh (Department of Medicine, McGill Life Science Complex) Dr. Jose Teodoro (Rosalind and Morris Goodman Cancer Research Centre) Dr. Michel Tremblay (Rosalind and Morris Goodman Cancer Research Centre) Dr. Christos Tsoukas (Immune Deficiency Treatment Centre – IDTC, Montreal General

Hospital) Dr. Bernard Turcotte (Hormones & Cancer Research Unit, Department of Medicine) Dr. Brian Ward (Montreal General Hospital) Dr. Ji Zhang (Biomedical Sciences, Faculty of Dentistry)

Adjunct Professors Dr. Jacques Archambault Dr. Cheolho Cheong Dr. Albert Descoteaux Dr. Andres Finzi Dr. Peter C. K. Lau Dr. Sylvie Lesage Dr. Shan-lu Liu Dr. Ancuta Petronela Dr. Woong-Kyung Suh


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Section II Research


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A. Research Grants Awarded in 2013 (listed only those in which primary members involved. TOTAL APPROXIMATE FUNDING FOR 2013 = $10,906,521)

Agency Grant Title Amount Researcher CIHR GET-FACTS: Genetics Environment and

Therapies: Food allergy clinical tolerance studies

$1,960,606 Fritz, Jorg Piccirillo, Ciro

CIHR Molecular mechanisms involved in resistance to different classes of RT inhibitors

$665,000 Goette, Matthias

CIHR Interactions between components of the HCV replication complex


CIHR Genetic dissection of the host response to intestinal infections

$584,870 Gruenheid, Samantha

CIHR Resistance of C. rodentium and related pathogens to antimicrobial peptides


CIHR T follicular helper cell differentiation and function in immunity and infection

$750,000 King, Irah

CIHR Molecular regulation of dendritic cell function $790,890 Krawczyk, Connie

CIHR Regulation of T cell Activation by Stomatin-Like Protein 2

$741,865 Madrenas, Joaquin

CIHR Mortality risks in later life from exposure to pandemic influenza in early life: the 1890 and 1918 influenza pandemics in Canada

$272,567 Madrenas, Joaquin

CIHR Canadian National Transplant Research Program

$13.8x106 Madrenas, Joaquin

CIHR Control of Leishmania pathogenesis $748,000 Matlashewski, Greg

CFI Establishment of a laboratory for the study of TH2-driven humoral immunity to infection

$200,000 King, Irah

CFI Molecular regulation of dendritic cell function $250,000 Krawczyk, Connie

FPQIS Exploiting plant made vaccines to protect the elderly against respiratory viruses

$300,000 Krawczyk, Connie

FQRNT Creation d’une nouvelle plateforme pour la characterization de l’ARN polymerase du virus de l’hepatite C (NS5V) et de ces d’inhibiteurs a l’echelle de la molecule individuelle


FQRNT Les systemes de regulation a deux composantes comme cibles therapeutiques pour le traitment des infections causes par les E. coli enteropathogenes



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FQRNT Les systemes de regulation a deux composantes comme cibles therapeutiques pour le traitement des infections causes par les Escherichia coli enteropathogens

$180,000 Le Moual, Herve

FRQS Inhibition of viral polymerases and evolution of drug resistance


Grand Challenge Canada – Bill and Melinda Gates

Point of care diagnosis of visceral Leishmaniasis in India

$887,000 Matlashewski, Greg

Grant Challenge Canada – Stars in Global Health

Development of a diagnostic test to detect Leishmania in the blood

$113,000 Matlashewski, Greg

McGill University Collaborative Research Development Fund

Chronic bacterial prostatitis, prostate hyperplasia and prostate cancer


MELS Supporting active learning and technological innovation in the teaching of science

$10,750 Coulton, James

NSERC Evolution of mobile group II introns $250,000 Cousineau, Benoit

NSERC Bacterial effector proteins as tools to study cell biology


NSERC miRNA regulation of dendritic cell function $130,000 Krawczyk, Connie

NSERC Signal Transduction by bacterial Ser/Thr kinases

$125,000 Le Moual, Herve

NSERC Role of Iron in the Regulation of PTPs: Impact of Cell signaling and Function

$240,000 Olivier, Martin

PSR-MIEIE $35,000 Sheppard, Don

B. Awards Briedis, Albert

• MIMM Best Anecdote Award

Cousineau, Benoit • William Dawson Award

Fritz, Jorg


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• CIHR New Investigator Award • FRQS Junior 1 Award

Götte, Matthias • Career Award: FRSQ ‘Chercheur National’

Gruenheid, Samantha • Tier II Canada Research Chair in Bacterial Pathogenesis

King, Irah • Tier II Canada Research Chair

Madrenas, Joaquin • Tier I Canada Research Chair in Human Immunology

Matlashewski, Greg • Elected Fellow of the Canadian Academy of Health Sciences

Piccirillo, Ciriaco • MUHC-RI award • Tier II Canada Research Chair • Research Excellence Fellows hip MUHC- MGH Foundation • Phil Gold Award for Research Excellence

Sagan, Selena • National CIHR Research training program in Hepatitis C (NCRTP- HepC) Annual PAC

Meeting, 2013. Poster prize. Biomedical Sciences.

Sheppard, Donald • FRSQ Chercheur Boursier Senior

Wainberg, Mark

• Premio Venizia Award for Scientific Research, Italy-Canada Chamber of Commerce • CIHR-CMAJ Top Canadian Achievements in Health Research Award

C. Publications Coulton, James

• Mah W, Deme JC, Watkins D, Fung S, Janer A, Shoubridge EA, Rosenblatt DS, Coulton JW. Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism. Molecular Genetics and Metabolism. 2013 108:112-118.


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• Mills A, Le HT, Coulton JW, Duong F. FhuA interactions in a detergent-free nanodisc

environment.. Biochimica et Biophysica Acta. 2013 1838:364-371.

Cousineau, Benoit • Schwartz J.S., Peres, A.G., Endam, L.M., Cousineau, B., Madrenas, J., Desrosiers, M.

(2013). Topical Probiotics as a Therapeutic Alternative for Chronic Rhinosinusitis: A Pre-Clinical Proof of Concept. International Forum of Allergy and Rhinology, (In Press, Accepted November 2013)

Fritz, Jörg • Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals

hyphal β-glucan from the immune system. Gravelat FN, Beauvais A, Liu H, Lee MJ, Snarr BD, Chen D, Xu W, Kravtsov I, Hoareau CM, Vanier G, Urb M, Campoli P, Al Abdallah Q, Lehoux M, Chabot JC, Ouimet MC, Baptista SD, Fritz JH, Nierman WC, Latgé JP, Mitchell AP, Filler SG, Fontaine T, Sheppard DC. PLoS Pathog. 2013;9(8):e1003575. doi: 10.1371/journal.ppat.1003575. Epub 2013 Aug 22.

• Arginine cools the inflamed gut. Fritz JH. Infect Immun. 2013 Oct;81(10):3500-2. doi:

10.1128/IAI.00789-13. Epub 2013 Jul 29.

• IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans. Flaczyk A, Duerr CU, Shourian M, Lafferty EI, Fritz JH, Qureshi ST. J Immunol. 2013 Sep 1;191(5):2503-13. doi: 10.4049/jimmunol.1300426. Epub 2013 Jul 26.

• The composite cytokine p28/cytokine-like factor 1 sustains B cell proliferation and

promotes plasma cell differentiation. Tormo AJ, Meliani Y, Beaupré LA, Sharma M, Fritz JH, Elson G, Crabé S, Gauchat JF. J Immunol. 2013 Aug 15;191(4):1657-65. doi: 10.4049/jimmunol.1201595. Epub 2013 Jul 8.

Götte, Matthias • Formation of a Quaternary Complex of HIV-1 Reverse Transcriptase with a Nucleotide-

competing Inhibitor and its ATP Enhancer. Ehteshami M, Nijhuis M, Bernatchez JA, Ablenas CJ, McCormick S, deJong D, Jochmans D, Götte M#. J Biol Chem. Jun 14;288(24):17336-46.

• Marko R, Liu HW#, Ablenas CJ, Ehteshami M, Götte M#, Cosa #. Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV-1 Reverse Transcriptase on DNA-DNA Substrates at the Single-Molecule Level. J Phys Chem B. 2013 Apr 25;117(16):4560-7.


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• Bennett N, Goette M. Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs. Viruses. (2013) Jan 8; 5(1):54-86.

• Eds S LeGrice and M Götte. ‘HIV Reverse Transcriptase: A Bench-to-Bedside Success’, Springer, 2013.

• Beilhartz GL, Scarth B, Götte M. Targeting Translocation of HIV-1 Reverse Transcription. In ‘HIV Reverse Transcriptase: A Bench-to-Bedside Success’; Eds LeGrice and Götte. Springer, 2013.

Gruenheid, Samantha • Papapietro O, Teatero S, Thanabalasuriar A, Yuki KE, Diez E, Zhu L, Kang E, Dhillon S,

Muise AM, Durocher Y, Marcinkiewicz MM, Malo D, Gruenheid S. R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun. 2013;4:1898.

• Comery R, Thanabalasuriar A, Garneau P, Portt A, Boerlin P, Reid-Smith RJ,Harel J, Manges AR, Gruenheid S. Identification of potentially diarrheagenic atypical enteropathogenic Escherichia coli strains present in Canadian food animals at slaughter and in retail meats. Appl Environ Microbiol. 2013 Jun;79(12):3892-6.

• Thanabalasuriar A, Kim J, Gruenheid S. The inhibition of COPII trafficking is important for intestinal epithelial tight junction disruption during enteropathogenic Escherichia coli and Citrobacter rodentium infection. Microbes Infect. 2013 Sep-Oct;15(10-11):738-44.

• Thomassin JL, Lee MJ, Brannon JR, Sheppard DC, Gruenheid S, Le Moual H. Both Group 4 Capsule and Lipopolysaccharide O-Antigen Contribute to Enteropathogenic Escherichia coli Resistance to Human α-Defensin 5. PLoS One. 2013 Dec 4;8(12):e82475.

• Brannon JR, Thomassin JL, Desloges I, Gruenheid S, Le Moual H. Role of uropathogenic Escherichia coli OmpT in the resistance against human cathelicidin LL-37. FEMS Microbiol Lett. 2013 Aug;345(1):64-71.

• Papapietro O, Gruenheid S. [Rspo2 controls C. rodentium infection outcome in mice]. Med Sci (Paris). 2013 Aug-Sep;29(8-9):688-90.

King, Irah • Irah L King, Eyal Amiel, Michael Tighe, Katja Mohrs, Natacha Veerapen, Gurdyal S

Besra, Markus Mohrs, Elizabeth A Leadbetter. “The mechanism of splenic iNKT cell activation dictates localization in vivo.” Journal of Immunology. 2013 Jul 15;191(2):572-82.


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Le Moual, Hervé • Thomassin, J-L., Lee, M., Brannon, J.R., Sheppard, D.C., Gruenheid, S. and, Le Moual,

H. (2013) Both group 4 capsule and lipopolysaccharide O-antigen contribute to enteropathogenic Escherichia coli resistance to a-defensin 5. PLoS One 8(12), e82475.

• Le Moual, H., Thomassin, J-L., Brannon J.R., (2013) Antimicrobial peptides as an

alternative approach to treat bacterial infections. J. Clin. Cell Immunol. S13-004, (Special issue: Innate Response to Infectious Diseases).

• Brannon, J.R., Thomassin, J., Desloges, I., Gruenheid, S. and Le Moual, H. (2013) Role

of uropathogenic Escherichia coli OmpT in the resistance against human cathelicidin LL-37. FEMS Microbiology Letters 345(1), 64-71.

Madrenas, Joaquin • El-Far M, Isabelle C, Chomont N, Bourbonnière M, Fonseca S, Ancuta P, Peretz Y,

Chouikh Y, Halwani R, Schwartz O, Madrenas J, Freeman GJ, Routy JP, Haddad EK, Sékaly RP. Down-Regulation of CTLA-4 by HIV-1 Nef Protein. PLoS One 2013; 8(1): e54295. doi: 10.1371/journal.pone.0054295.

• Peres AG, Madrenas J. The broad landscape of immune interactions with Staphylococcus aureus: From commensalism to lethal infections. Burns 2013; 39: 380.

• Yasin A, Liu D, Chau L, Madrenas J, Filler G. Fibroblast growth factor-23 and calcium phosphate product in young chronic kidney disease patients: a cross-sectional study. BMC Nephrol 2013; 14:39. doi: 10.1186/1471-2369-14-39.

• Gagnon A, Miller MS, Hallman SA, Bourbeau R, Herring DA, Earn DJD, Madrenas J. Age-specific mortality during the 1918 influenza pandemic: Unravelling the mystery of high young adult mortality. PLoS One 2013; 8(8): e69586. doi:10.1371/journal.pone.0069586.

• Mitsopoulos P, Madrenas J. Identification of Multimolecular Complexes and Supercomplexes in Compartment-Selective Membrane Microdomains. Methods Cell Biol 2013; 117: 411.

• Suarez-Fueyo A, Madrenas J, Criado G. A24584: Lymphocytes: antigen-induced gene activation. Version 3.0. Encyclopedia of Life Sciences 2013: John Wiley & Sons Ltd: Chichester http://www.els.net/ . DOI: 10.1002/9780470015902.a0001191.pub3.

• Schwartz J, Peres A, Mfuna Endam L, Cousineau B, Madrenas J, Desrosiers M. Topical Probiotics As A Therapeutic Alternative For Chronic Rhinosinusitis: A Pre-Clinical Proof Of Concept. Int Forum Allergy Rhinol 2013; in press.


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• Li J, Lee DSW, Madrenas J. Evolving Bacterial Envelopes and Plasticity of TLR2-dependent Responses: Basic Research and Translational Opportunities. Front Immunol 2013; 4: 347. doi: 10.3389/fimmu.2013.00347.

Matlashewski, Greg • Matlashewski G, Pandey R, Das VN, and Das P. One more death from visceral

leishmaniasis has gone by unnoticed. What can be done? (viewpoint) PLoS Negl. Trop. Dis. 7: e2082, 2013.

• Ranasinghe S, Wickremasinghe R, Munasinghe A, Hulangamuwa S, Seneviratne K,

Bandara S, Athauda I, Navaratne C, Silva O, Wackwella H, Matlashewski G, and Wickremasinghe R. A cross sectional study to assess risk factors for leishmaniasis in an endemic region of Sri Lanka. Am. J. Trop. Med. Hygen. 89: 742-747, 2013.

• Mondal D, Huda M, Karmoker M, Ghosh D, Matlashewski G, Nabi S, and Kroeger A. Reducing visceral leishmaniasis by insecticide impregnation of bed-nets. Emerg. Infect. Dis. 19: 1131- 1134, 2013.

• Matlashewski G, Das VNR, Pandey K, Singh D, Das S, GHosh AK, Pandey RN, Das P.

Diagnosis of visceral leishmaniasis in Bihar India: Comparison of the rK39 rapid diagnostic test on whole blood versus serum. PLoS Negl. Trop. Dis. 7: 5e2233, 2013.

• McCall L, Zhang W, and Matlashewski G. Determinants for the development of visceral

leishmaniasis disease (invited review). PLoS Path. 9:e1003053, 2013

• Tsukayama P, Nunezl J, Santos M, Sobero V, Lucas C, Matlashewski G, Llanoa-Cuentas A, Ore M, Baldevianol C, Edgel K, Lescano A, Graf P, and Bacon D. A FRET-Based Real-Time PCR Assay to Identify the Main Causal Agents of New World Tegumentary Leishmaniasis. PLoS Negl. Trop. Dis. 7: e1956, 2013.

• Zhang WW, McCall L, and Matlashewski G. The role of cytosolic glyceraldehyde-3-

phosphate dehydrogenase in visceral organ infection by Leishmania donovani. Euk. Cell 12: 70-77, 2013

• McCall L, Zhang W, Ranasinghe S, and Matlashewski G. Leishmanization revisited:

Immunization with a naturally attenuated cutaneous Leishmania donovani isolate from Sri lanka protects against visceral leishmaniasis. Vaccine 31: 1420-1425, 2013.

Olivier, Martin

• K. Hassani and M. Olivier. Immunomodulatory impact of Leishmania-induced exosomes: A comparative proteomic and functional analyses. PLoS Neglected Tropical Diseases 7(5): e2185. doi:10.1371/journal.pntd.0002185 (2013).


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• D. Matheoud, N. Moradin, A. Bellemare-Pelletier, M.T. Shio, W.J Hong, M. Olivier, É. Gagnon, M. Desjardins and A. Descoteaux. Leishmania inhibits antigen crosspresentation by direct cleavage of the SNARE VAMP8. Cell Host & Microbes 14:15-25 (2013).

• M. Byun, C.S. Ma, A. Akçay, V. Pedergnana, U. Palendira, J. Myoung, D.T. Avery, Y. Liu, A. Abhyankar, L. Lorenzo, M. Schmidt, H.-K.Lim, O. Cassa, M. Migaud, F. Rozenberg, N. Canpolat, G. Aydoğan, B. Fleckenstein, J. Bustamante, C. Picard, A. Gessain, E. Jouanguy, E. Cesarman, M. Olivier, P. Gros, L. Abel, M. Croft, S.G. Tangye, J.-L. Casanova. Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. Journal of Experimental Medicine 210:1743-59 (2013).

• N. Thawani, M. Tam, M.J. Bellemare, D.S. Bohle, M. Olivier, J.B.de Souza and M.M. Stevenson. Plasmodium products contribute to severe malarial anemia by inhibiting erythropoietin-induced proliferation of erythroid precursors. Journal of Infectious Diseases 209 : 140-149 (2013).

• Contreras, M.T. Shio, A. Cesaro, P.A. Tessier and M. Olivier. Impact of neutrophil-secreted myeloid related proteins 8 and 14 (MRP 8/14) on leishmaniasis progression. PLoS Neglected Tropical Diseases 7(9): e2461. doi:10.1371/journal.pntd.0002461 (2013).

Piccirillo, Ciriaco

• Kornete M., H. Beauchemin, C. Polychonakos and C.A. Piccirillo. Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. Autoimmunity. 2013 Jun;46(4):259-68

• Bjur, E., Larsson, O., Yurchenko E., Zheng L., Topisirovic, I, Sonenberg, N., Piccirillo,

C.A. Distinct translation control of gene expression in CD4+Foxp3+ regulatory T cells. (PLoS Genetics, May;9(5):e1003494.2013).

• Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, Gigoux M, Kornete M, Piccirillo CA, Suh WK, Yu XZ. Phosphatidylinositol 3-Kinase-Independent Signaling Pathways Contribute to ICOS-Mediated T Cell Costimulation in Acute Graft-Versus-Host Disease in Mice. J Immunol. 2013 Jul 1;191(1):200-7. Epub 2013 May 31.

• Bin Dhuban K., d'Hennezel E., Ben-Shoshan M., McCusker C., Clarke A. Fiset P., Mazer

B., and Piccirillo C.A. Altered Th17 Responses in Children with Food Allergy. Int Arch Allergy Immunol. 2013;162(4):318-22

• Belabani C, Rajasekharan S, Poupon V, Johnson T, Bar-Or A CIHR/MSSC NET in

Clinical Autoimmunity; Canadian Pediatric Demyelinating Disease Network. A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples. J Immunol Methods. 2013 Jan 31;387(1-2):1-10.


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• Massoud A.H., M.Yona, A.Ablona, M. W.Mourad, C.A. Piccirillo, B.D. Mazer. Dendritic Cell Immunoreceptor (DCIR) Mediates the Tolerogenic Effects of Intravenous Immunoglobulin in pulmonary inflammation. (J Allergy Clin Immunol. 2013 Nov 7. pii: S0091-6749(13)01476-0. doi: 10.1016/j.jaci.2013.09.029.)

• Zouk H, D'Hennezel E, Du X, Ounissi H, Piccirillo CA, Polychronakos C. Functional

evaluation of the role of CLEC16A at the chromosome 16p13 locus. Clin Exp Immunol. 2013 Nov 18. doi: 10.1111/cei.12240.

• Liston A. and C.A. Piccirillo*. Developmental plasticity of murine and human

commitment of Foxp3+ regulatory T cells. (commissioned by journal). Adv Immunol. 2013;119:85-106. doi: 10.1016/B978-0-12-407707-2.00003-5.

• M. Kornete, E. Mason and C.A. Piccirillo*. Immune Regulation in T1D and T2D:

Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment. Front Endocrinol. 2013 (commissioned by journal) Jun 25;4:76. doi: 10.3389/fendo.2013.00076.

• Piccirillo C.A*. Environmental sensing and regulation of gene expression in CD4+ T cell

subsets. Current Opinion in Immunology 2013 Oct;25(5):564-70. doi: 10.1016/j.coi.2013.09.006. Epub 2013 Oct 17. (commissioned by journal).

Sagan, Selena • Sagan SM and Sarnow P. RNAi, Antiviral After All. Science (2013) 342(6155):207-208.

• Cox EM, Sagan SM, Mortimer SA, Doudna JA, and Sarnow P. Enhancement of hepatitis

C viral RNA abundance by precursor miR-122 molecules. RNA (2013) Epub ahead of print Oct. 8, 2013.

• Grebely J, Bilodeau M, Feld JJ, Bruneau J, Fischer B, Raven JF, Wong T, Roberts E, Choucha N, Myers RP, Sagan SM, Wilson JA, Bialystok F, Tyrrell DL, Houghton M, and Krajden M on behalf of the National CIHR Research Training Program in Hepatitis C. The Second Canadian Symposium on Hepatitis C Virus Infection: A Call to Action. Can J Gastroenterol (2013) 27(11):627-632.

• Sagan SM*, Sarnow P, and Wilson JA. Modulation of GB virus B (GBV-B) RNA abundance by microRNA-122: Dependence on and escape from miR-122 restriction. J Virol. (2013) 87(13):7338-7347.

Sheppard, Donald

• Lee MJ, Gravelat FN, Cerone RP, Baptista SD, Campoli PV, Choe SI, Kravtsov I, Vinogradov E, Creuzenet C, Liu H, Berghuis AM, Latgé JP, Filler SG, Fontaine T,


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Sheppard DC*. (2013) Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides. Journal of Biological Chemistry. Nov 20. [Epub ahead of print]

• Thomassin J, Lee MJ, Brannon JR, Sheppard DC, Gruenheid S, Le Moual H. (2013)

Both Group 4 Capsule and Lipopolysaccharide O-Antigen Contribute to Enteropathogenic Escherichia coli Resistance to Human α-Defensin 5. PLoS One. 2013 Dec 4;8(12):e82475

• Nucci M, Marr K, Vehreschild M, de Souza C, Velasco E, Cappellano P, Carlesse F,

Queiroz-Telles F, Sheppard DC, Kindo A,Cesaro S, Hamerschlak N, Solza C, Heinz W, Schaller M, Atalla M, Arikan-Akdagli S, Bertz M,Castro Jr. C, Herbrecht R, Hoenigl M, Härter G, Hermansen EN, Josting A, Pagano L, Salles M, Mossad SB, Ogunc D, Pasqualotto A, Araujo V, Troke P, Lortholary O, Cornely O, Anaissie E. (2013) Improvement in the outcome of invasive fusariosis in the last decade. Clinical Microbiology and Infection, Oct 1 Epub

• Gravelat FN, Beauvais A, Liu H, Lee MJ, Snarr B, Chen D, Xu W, Kravtsov I, Hoareau

CMQ, Vanier G, Urb M, Campoli P, Al Abdallah Q, Lehoux M, Chabot JC, Ouimet MC, Baptista, S, Fritz JH, Nierman W, Latge JP, Mitchell AP, Filler SG, Fontaine T, and Sheppard DC*. (2013) Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-glucan from the Immune System. PLoS Pathogens. Aug;9(8):e1003575.

• Mulintia, P, Allena NA, Coylea CM, Gravelat FN, Sheppard DC, and Panaccione DG.

(2013) Accumulation of ergot alkaloids during conidiophore development in Aspergillus fumigatus. Current Microbiology, epub Aug 8.

• Development and evaluation of a calibrator material for nucleic acid-based assays for

diagnosing aspergillosis. (2013) Lyon GM, Abdul-Ali D, Loeffler J, White PL, Wickes B, Herrera ML, Alexander BD, Baden LR, Clancy C, Denning D, Nguyen MH, Sugrue M, Wheat LJ, Wingard JR, Donnelly JP, Barnes R, Patterson TF, Caliendo AM; AsTeC, IAAM, EAPCRI Investigators. J Clin Microbiol. Jul;51(7):2403-5.

• Pagano L, Cornely O, Busca O, Caira O, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ,

Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Raci Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, and Vehreschild MJGT. (2013) Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries. Haematologica. Oct;98(10):e127-30.

• Campoli P., Perlin DS, Kristof A, White TC, Filler SG and Sheppard DC*. (2013)

Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis. Journal of Infectious Diseases. Nov 15;208(10):1717-28


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• Litvinov I, St Germain G, Pelletier R, Paradis M, Sheppard DC. (2013) Endemic human

blastomycosis in Quebec, Canada (1988-2011). Epidemiology and Infection, Jun;141(6):1143-7.

Wainberg, Mark • Brenner BG, Wainberg MA, Roger M. Phylogenetic inferences on HIV-1 transmission.

Implications for the design of prevention and treatment interventions. AIDS 2013; 27:1045-1057.

• Asahchop E, Oliveira M, Quashie P, Moisi D, Martinez-Cajas J, Brenner BG, Tremblay

C, Wainberg MA. In Vitro and Structural Evaluation of PL-100 as a Potential Second Generation HIV-1 Protease Inhibitor. Journal Antimicrob Chemother. 2013 Jan;68(1):105-12

• Mesplède T, Quashie PK, Osman N, Han Y, Singhroy DN, Lie Y , Petropoulos CJ,

Huang W and Wainberg MA. Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure. Retrovirology 2013; 10:22.

• Lisovsky I, Schader SM, Sloan RD, Oliveira M, Coutsinos D, Bernard NF, Wainberg

MA. HIV-1 Subtype Variability in Vif Derived from Molecular Clones Affects APOBEC3G-Mediated Host Restriction. Intervirology. 2013. 56(4): 258-264. DOI:10.1159/000348513

• Parsons MS, Center RJ, Routy JP, Rouleau D, Leblanc R, Wainberg MA, Tremblay CL,

Zannou MD, Kent SJ, Grant MD, Bernard NF. Antibody Responses to Human Immunodeficiency Virus Envelope from Infections with Multiple Subtypes Utilize the 1F7-Idiotypic Repertoire. AIDS Res Hum Retroviruses. 2013 May;29(5):778-83.

• Han YS, Xiao WL, Quashie PK, Mesplède T, Xu H, Deprez E, Delelis O, Pu JX, Sun

HD, Wainberg MA. Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors. Antiviral Res. 2013. 98(3):441-448

• Asahchop EL , Wainberg MA, Oliveira M, Xu H, Brenner BG, Moisi D, Ibanescu IR ,

and Tremblay C.Distinct Resistance Patterns to Etravirine and Rilpivirine in Viruses Containing NNRTI Mutations at Baseline. AIDS 2013, 27:879–887

• Xu HT, Colby-Germinario SP, Asahchop EL, Oliveira M, McCallum M, Schader SM,

Han Y, Quan Y, Sarafianos SG, and Wainberg MA. The Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and their Interactions with the M184I Mutation in Defining Patterns of Resistance to the Non-Nucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine. Antimicrobial Agents Chemother. 2013. 57(7): 3100-3109


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• Invernizzi C, Coutsinos, D, Oliveira M, Schildknecht R, Xu Ho-T, Gaseitsiwe S; Moisi D; Brenner BG, Wainberg MA. The Preferential Selection of K65R in HIV-1 Subtype C Is Attenuated by Nucleotide Polymorphisms at Thymidine Analogue Mutation Sites. Journal Antimicrob Chemother 2013. 68(10):2192-2196.

• Sloan RD, Kuhl BD, Mesplède T, Münch J, Donahue DA, and Wainberg MA. Productive

entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis. J. Virol 2013. 87(14):8110-8123

• Chen L, Ao Z, Jayappa KD, Kobinger G, Liu SP, Wu G, Wainberg MA, and Yao X.

Characterization of antiviral activity of a benzamide derivative AH0109 against HIV-1 infection. Antimicrobial Agents Chemother 2013 57(8):3547-3554.

• Gupta RK, Wainberg MA, Brun-Vezinet F, Gatell JM, Albert J,Sönnerborg A and

Nachega JB. Oral Antiretroviral Drugs as Public Health Tools for HIV Prevention: Global Implications for Adherence, Drug Resistance, and the Success of HIV Treatment Programs. Journal of Infectious Diseases 2013. 207(Suppl.2):5101-5106

• Heredia A, Davis CE, Reitz MS, Le Nhut M, Wainberg MA, Foulke JS, Wang Lai-X,

and Redfield RR. Targeting of the Purine Biosynthesis Host Cell Pathway Enhances the Activity of Tenofovir Against Sensitive and Drug-Resistant HIV-1. Journal of Infectious Diseases. 2014 208(12):2085-94

• Donahue DA, Bastarache SM, Sloan RD, Wainberg MA. Latent HIV-1 can be reactivated

by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses. J Virol. 2013. 87(17):9620-9632.

• Singhroy DN, Mesplède T, Sabbah A, Quashie PK, Falgueyret PK, Wainberg MA.

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti- HIV-1 activity. Retrovirology. 2013. 10:73.

• McCallum M, Oliveira M, Ibanescu RI, Kramer V, Moisi D, Asahchop E, Brenner B,

Harrigan R, Xu HT, and Wainberg MA . Basis for the Early and Preferential Selection of the E138K Mutation in HIV-1 Reverse Transcriptase. Antimicrobial Agents Chemother 2013;57(10):4681-8

• Gupta RK, Van de Vijvers DAMC, Manicklal S and Wainberg MA. Evolving uses of

oral reverse transcriptase inhibitors in the HIV-1 epidemic: from treatment to prevention. Retrovirology. 2013. 10:82.

• Xu HT, Colby-Germinario SP, Huang W, Oliveira M, Han Y, Quan Y, Petropoulos CJ,

and Wainberg MA. Roles of the K101E Mutation in HIV-1 Reverse Transcriptase in Resistance to Rilpivirine and other Non-Nucleoside Reverse Transcriptase Inhibitors. Antimicrob Agents Chemother. 2013. 57(11): 5649-5657.


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D. Presentations and Lectures Briedis, Dalius

• Treatment of community acquired pneumonia, Invited Speaker, McGill Universities Continuing Medical Education 44th Annual Course in Drug Therapy, Delta Hotel, Montreal, May 2-3rd, 2013.

• Adult vaccines. Invited Speaker, McGill Universities Continuing Medical Education

Thursday Evening Learning Series March 21, 2013. Cousineau, Benoit

• Schwartz J.S., Al-Mot, S., Endam, L.M., Cousineau, B., Madrenas, J., Desrosiers, M. Safety assessment of topical probiotics for CRS: Elevated IL-10 levels do not contribute to epithelial hyperplasia in CRS. American rhinologic society annual meeting, Vancouver, BC, Canada, September 2013.

• Peres, A.G., Stegen, C., Cousineau, B., Desrosier, M., and Madrenas, J. (2013). The pro- and anti-inflammatory TLR2 responses to S. aureus can be uncoupled. AAI Immunology. Hawaii, USA.

• Schwartz J.S., Peres, A.G., Endam, L.M., Cousineau, B., Madrenas, J., Desrosiers, M. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A pre-clinical proof of concept. American rhinologic society annual meeting, Vancouver, BC, Canada, September 2013.

• Schwartz J.S., Peres, A.G., Endam, L.M., Cousineau, B., Madrenas, J., Desrosiers, M. Probiotique topique comme alternative therapeutique pour la rhinosinusite chronique. Congrès annuel de l'association d'oto-rhino-laryngologie et de chirurgie cervico-faciale du Québec, Montreal, Quebec, Canada, October 2013.

• Peres, A.G., Stegen, C., Cousineau, B., Desrosier, M., and Madrenas, J. (2013). The pro- and anti-inflammatory TLR2 responses to S. aureus can be uncoupled. AAI Immunology. Hawaii, USA.

• Peres, A.G., Stegen, C., Cousineau, B., Desrosier, M., and Madrenas, J. (2013). The pro- and anti-inflammatory responses to S. aureus can be uncoupled. McGill Microbiology and Immunology Graduate Research Day. Montreal, Canada.

Fournier, Sylvie

• More thinking, less cookbook: redesigning an undergraduate immunology lab course. Claire Trottier and Sylvie Fournier, The Western Conference on Science Education, London, Ontario, July 9-11 2013. Oral Presentation.


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• Neuropathy in an animal model of CD8+ T cell-mediated CNS demyelination. Anthony Rainone and Sylvie Fournier, AAI Centenial Meeting, Hawaii, May 2013. Poster presentation.

• Neuropathy in an animal model of CD8+ T cell-mediated CNS demyelination. Anthony Rainone and Sylvie Fournier, 8th Annual Symposium CIHR Training Program in Neuroinflammation, Montreal, June 2013. Poster presentation

Fritz, Jörg

• “Regulation of innate B cells by Nod1”. 15th International Congress of Immunologists, Milan, Italy 2013.

• “Regulation of intestinal homeostatis by IgA+ Plasma cells”. 10th Symposium of the physiology of diseases of the digestive tract. (PDGI 2013). Orford, Quebec.

Götte, Matthias

• Invited Presentation: University of Saskatchewan, Saskatoon, Saskatchewan, Canada, March 6, 2013

• Invited Presentation: University of Utrecht, The Netherlands, April 24, 2013 Gruenheid, Samantha

• 10th Symposium on the Physiology and Diseases of the Digestive Tract, Oct.2-4th 2013. Refereed presentation (abstract selected for talk)

• University of Sherbrooke Department of Microbiology and Infectious Disease

Intestinal R-spondin 2 signaling and susceptibility to Citrobacter rodentium infection Invited speaker, May 30th

• Institute Armand Frappier

Rspondin 2, Wnt, and susceptibility to C. rodentium infection Invited speaker, March 26th

King, Irah

• Invited Speaker: RIKEN-McGill joint conference, June 21, 2013

• Invited Speaker : Gordon Conference on T follicular helper cells, July 21-26, 2013

• 2013 University of Montreal, Montreal, Quebec: “Mechanisms of T follicular helper cell localization in the germinal center during infection”

• 2013 McMaster University, Hamilton, Ontario: “Mechanisms of T follicular helper cell localization in the germinal center during infection”


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• 2013 INRS-Institut Armand-Frappier, Laval, Quebec: ““Mechanisms of T follicular helper cell localization in the germinal center during infection”

Krawczyk, Connie

• 4th Canadian Cytometry and Microscopy Symposium, Montreal, QC, Canada (Invited) - Detecting antigen-specific T cells

• Hospital Maisonneuve-Rosemont, University of Montreal, Novel Mechanisms

Regulating Dendritic Cell Function Le Moual, Hervé

• Le Moual, H. Bacterial resistance to host antimicrobial peptides. Invited speaker, Microbiology & Infectious Diseases Asia Congress, Singapore. June 2014.

• Thomassin, J., Brannon, J.R., Gruenheid, S. and Le Moual, H. Enteropathogenic and enterohemorrhagic Escherichia coli use different mechanisms to resist human antimicrobial peptides. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.

• Brannon, J.R., Thomassin, J., Gruenheid, S. and Le Moual, H. The Citrobacter rodentium outer-membrane protease CroP cleaves mCRAMP more rapidly than LL-37. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.

• Desloges, I., Gruenheid, S. and Le Moual, H. Activity of the outer-membrane protease OmpT among uropathogenic Escherichia coli clinical isolates. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.

• Viau, C. and Le Moual, H. Phosphoethanolamine modifications promote LPS transfer to the outer membrane. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.

• Premjani V., Gruenheid S., Le Moual H., and John A. Samis, J.A. Enterohemorrhagic Escherichia coli OmpT regulates outer membrane vesicle composition and biogenesis. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.

• Premjani V., Gruenheid S., Le Moual H., Weitz J., and John A. Samis, J.A. Enterohemorrhagic Escherichia coli cellular and outer membrane vesicle OmpT attenuates blood coagulation. The 63rd Annual Conference of the Canadian Society of Microbiologists, Carleton University, Ottawa, Ontario, June 2013.


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• Thomassin, J., Gross, J., Giannakopoulu, N., Salmon, K., Zhu, L., Gruenheid, S., and Le Moual, H. Identification and characterization of an essential two-component regulatory system for Citrobacter rodentium infection. The 12th Annual McGill Biomedical Graduate Conference (AMBGC), Feb. 28, 2013.

• Brannon, J.R., Thomassin, J., Gruenheid, S. and Le Moual, H. Citrobacter rodentium outer-membrane protease rapidly degrades the murine cathelicidin mCRAMP but not human LL-37. The 12th Annual McGill Biomedical Graduate Conference (AMBGC), Feb. 28, 2013

Madrenas, Joaquin

• The Do’s and Do Not’s of Grant Writing. McGill University Office of Sponsored Research Workshop, Montreal, QC, January 8, 2013.

• Infectious Music: how microbes have shaped our music. Division of Nephrology Rounds, Université de Montréal, Montreal, QC. Jan 15, 2013.

• The two sides of S. aureus: from commensalism to dialysis nightmares. CHUM-MUHC Nephrology Research Conference. Montreal, QC. Jan 15, 2013.

• The Art (and Science) of Grant and Abstract Writing. Canadian Society of Transplantation (CST) Research Fellows in Transplantation Symposium (Research FITS), Lake Louise, Alberta, March 13, 2013 (Declined).

• Infectious Music: how microbes have shaped our music. McGill Society of Montréal Public Lecture Series, Montreal, QC. March 26, 2013.

• Keynote Speaker: La doble cara del S. aureus: desde commensal a microbio letal. IX Congreso Colombiano de Alergia, Asma e Inmunologia, Bogota, Colombia, May 2-4, 2013.

• Nuevos mecanismos reguladores de la activacion de los linfocitos T. IX Congreso Colombiano de Alergia, Asma e Inmunologia, Bogota, Colombia, May 2-4, 2013.

• Musica infecciosa: nuestra música a través de las enfermedades infecciosas. IX Congreso Colombiano de Alergia, Asma e Inmunologia, Bogota, Colombia, May 2-4, 2013.

• Plenary Seminar System Immunobiology of S. aureus commensalism and infection. Annual 3IQ Retreat, Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, May 22, 2013.

• The Do’s and Do Not’s of Grant Writing. CIHR Institute of Infection and Immunity New Investigator Forum, Manoir du Lac Delage, Lac Delage QC, June 1, 2013.


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• Chair: Mock CIHR IT Review Panel Session. CIHR Institute of Infection and Immunity

New Investigator Forum, Manoir du Lac Delage, Lac Delage QC, June 1, 2013.

• Speed-dater. 42nd Annual Meeting of the Canadian Science Writers’ Association. Montreal, QC, June 6-8, 2013.

• The Do’s and Do Not’s of Grant Writing. McGill University Office of Sponsored Research Workshop, Montreal, QC, June 12, 2013.

• Novel Mechanisms of Regulation of T Cell Activation. Université de Montréal Séminaire de Recherche, Axe Infection, Immunité et Inflammation. CHUM – Hôpital Notre-Dame, Montréal, QC, June 14, 2013.

• Plenary Lecture: Taming a superbug: The S. aureus story. 4th Canadian Cytometry and Microscopy Symposium, Montreal, QC, June 13‐15, 2013.

• Taming a superbug: System immunobiology of S. aureus commensalism. Meakins-Christie Laboratories Beer Seminar, Montreal, QC, September 9, 2013.

• The two sides of S. aureus: from commensalism to dialysis nightmares. CHUM – MUHC Nephrology Research Conference, Montreal, QC, September 17, 2013.

• On the role of SLP-2: Mitochondrial Membrane Compartmentalization and Optimal Respiratory Chain Assembly. Institut fuer Genetik, Universitaet zu Koeln, Cologne, Germany, October 14, 2013.

• Stomatin-Like Protein-2 Modulates Cell Function by Regulating Mitochondrial Membrane Compartmentalization and Respiration. 4th World Congress on Targeting Mitochondria, Berlin, Germany, October 17, 2013.

• On the Search for Mechanisms of S. aureus Pathobiosis. 19e « 5 à 7 » d’Immunologie Montréal, Université de Montréal, October 30, 2013.

• System Imunobiology of Microbial Commensalism: The S. aureus Story. Vertex Pharmaceuticals Canada, Laval, QC, November 13, 2013.

• Infectious Music: how microbes have shaped our music. Atwater Library and Computer Centre Lunchtime Series. Montreal, QC, November 29, 2013.

• CIHR Foundation Grants Information Session. McGill University Office of Sponsored Research Workshop, Montreal, QC, December 10, 2013.


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• Taming a Superbug: Systems Immunobiology of S. aureus Commensalism. University of Toronto, Department of Immunology Special Seminar, Toronto, ON, December 13, 2013.

Marczynski, Greg

• “A Genetic and Biochemical Approach Identifies a New Regulator of Bacterial Chromosome Replication”, Canadian Society of Microbiology meeting, Ottawa, ON, 20 June 2013.

• “The Impact of duf299 operon regulation on initiation of chromosome replication in Caulocabcter crescentus”, Canadian Society of Microbiology meeting, Ottawa, ON, 20 June 2013.

Matlashewski, Greg • The use of Village ASHAs for active case detection of visceral leishmaniasis cases.

WHO meeting to set research priorities for elimination of visceral leishmaniasis. Freiburg, Germany. Sept. 24, 2013

• Live attenuated vaccine of visceral leishmaniasis. American Association of Tropical Medicine and Hygiene. Invited speaker. Washington DC. Nov. 15, 2013

• Elimination of visceral leishmaniasis through implementation research. Institute of

Parasitology. McGill University. March 1, 2013

• Elimination of visceral leishmaniasis through implementation research. University of Calgary. Calgary, August 22, 2013

• Elimination of visceral leishmaniasis through implementation research. Department of Microbiology and Immunology, McGill University. October 3, 2013

Olivier, Martin

• Role of Leishmania Metalloprotease GP63 in Evasion of Macrophage Innate Immune Response. Symposium on Leishmania-Macrophage Interaction. World Leish 5 Meeting, Recife, Brazil. May 2013

• Role of Innate Immunity in the Development of Malaria Related Pathologies. Symposium: Immunology of Parasitic Infection. 88th Annual American Society for Parasitology and 13th Annual Québec Molecular Parasitology Meeting, Québec, Qc, Canada. June 2013

• Leishmania GP63 Metalloprotease: A New Tool to Control Bacterial Mediated Inflammation. Workshop on Immunology to Bacterial infection, 15th International Congress of Immunology, Milano, Italy, August 2013.


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• Phosphatases, Métalloprotéases et Leishmaniose : Un Trio Dangereux…INRS/Institut Armand-Frappier. Laval-des-Rapides, Qc, Canada. February 2013

• Pathogen-Macrophage Interaction: A signaling story. MUHC and the McGill International TB Centre, Montréal, Qc, Canada. April 2013

• From Hemozoin to Cerebral Malaria: Adventure Into Innate Immunity. Meakins-Christie Laboratories, Montréal, Qc, Canada. November 2013

Piccirillo, Ciriaco • CCMA Invited Speaker

• RIKEN Workshop Invited Speaker

• International Congress in Immunology Invited Oral Presentation

• Microbiology and Immunology Infection and Immunity Seminar Series

• Immune Tolerance in Allergic Disease Symposium

• Complex Traits Group

• Lady Davis Research Institute

Sagan, Selena

• Sarnow, P., Sedano, M., and Sagan, S.M. “Micro RNA-mediated control of hepatitis C virus”. Oral Presentation. HepDART, Big Island, Hawaii, USA, Dec.8-12, 2013.

• Sagan, SM, Cox, EM, Wilson, JA, and SArnow P. “Human miR-122 mediated viral RNA

accumulation in hepaciviruses”. Oral Presentation. Life Science Research Foundation (LSRF) Annual Meeting, Baltimore, MD, USA, Oct. 18-20, 2013.

• Sagan SM, Sarnow P. “miR-122 and Hepatitis C virus: investigating the requirements of

an unusual microRNA- target RNA interaction” Poster presentation. National CIHR research training program in Hepatitis C (NCRTP-HepC) Annual PAC meeting, Victoria, Canada. March 2-3, 2013

• Sagan SM, Cox EM, Wilson JA and Sarnow P. “One microRNA to rule them all: Human

miR-122 mediates viral RNA accumulation in hepaciviruses”. Invited oral presentation, Virology Interest group –NIH, Methesda, MD, USA, October 17th, 2013.

• Sagan, SM, Sarnow P and Wilson JA. “Modulation of GB virus B (GBV-B) RNA

abundance by microRNA-122: Dependence on and escape from miR-122 restriction”. Oral presentation, Departmental Seminar Series, Department of Microbiology and Immunology, Stanford University, Stanford, California, USA. April 24, 2014.

Sheppard, Donald


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• Hematology Grand Rounds, Cross Cancer Institute, Edmonton Alberta. Combining prophylaxis and diagnostics to manage fungal infections. February 6 2013

• Invited Speaker, Philippines Infectious Disease Society Annual Meeting, Manila,

Philippines. Uncertainty in diagnostics for fungal infections. November 28 2013

• Invited Speaker, Infectious Diseases Seminar Series, University Hospital Zurich, Switzerland. Effects of hydrophobicity on activity and pharmacokinetics of antifungals. November 15 2013.

• Invited Speaker, Annual Meeting of the German, Swiss and Austrian Society of

Hematology and Oncology, Vienna, Austria. Mechanisms of action of hydrophobic antifungals. October 20 2013

• Invited Speaker, Cold Spring Harbor Meeting on Molecular Pathogenesis and Host

Response. Cold Spring Harbor Laboratory, NY, USA. Identification and characterization of an exopolysaccharide that confers virulence on the mold Aspergillus fumigatus. Sept 18 2013

• Invited Speaker, Hematology Grand Rounds, Prince of Wales Hospital, Sydney,

Australia. Effects of hydrophobicity on activity and pharmacokinetics of antifungals. Aug 15 2013

• Molecular Mycology of Pathogenic Fungi Summer Course, Marine Biology Laboratories,

Woods Hole, Massachusetts. (Invited Faculty). Identification and characterization of a novel virulence factor of Aspergillus fumigatus. Aug 4 2013

• Master Class in Management of Fungal Diseases. Tokyo, Japan. Integrating diagnostics

into the management of fungal infections. July 3 2013

• Invited Speaker, Hematology Grand Rounds, Royal Melbourne Hospital. Melbourne, Australia. Effects of hydrophobicity on activity and pharmacokinetics of antifungals. June 18th 2013

• Invited Speaker, European Bone Marrow Transplant Society Symposium. London,

England. Hydrophobicity: A novel paradigm of antifungal activity. April 7 2013

• Invited Seminar: Singapore General Hospital Hematology Seminar Series. Effects of hydrophobicity on activity and pharmacokinetics of antifungals. March 15 2013

• Invited Speaker 9th International Symposium on Antimicrobial Agents and Resistance

(ISAAR 2013), Kuala Lumpur, Malaysia Early Antifungal Treatment Strategies – rationalizing antifungal use through Pk/Pd. March 14 2013


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• Invited Seminar: Catalan Oncology Institute. Barcelona, Spain. Effects of hydrophobicity on pharmacokinetics and pharmacodynamics of antifungals. Feb 19th 2013

• Invited Seminar: Valencia University Hospital, Valencia Spain. Effects of hydrophobicity

on pharmacokinetics and pharmacodynamics of antifungals. Feb 21 2013 Wainberg, Mark

• January 18, 2013. Africa-Canada Research Forum on HIV/AIDS. Entebbe, Uganda. “The use of Integrase Inhibitors in the Treatment of HIV Disease”.

• February 2013. Department of Molecular Medicine, Colorado State University, Fort Collins, Colorado. “Is Dolutegravir a Qualitative Deifferent Drug for the Treatment of HIV”.

• February 12, 2013. Killam Award Lecture I, Faculty of Medicine, University of British Columbia, Vancouver, BC. Drug Resistance in HIV: What Can We Do about It

• February 13, 2013. St. Paul’s Hospital, Vancouver, B.C. “Will Integrase Inhibitors

Represent a paradigm Shift in the Management of HIV Disease?”

• March 2013. European HIV/HCV Drug Resistance conference. Rome. Italy. “Resistance mutations for Dolutegravir and their impact on viral fitness”.

• April 2013. Infectious Disease Rounds, University of Pennsylvania, Philadelphia, PA. “Will Integrase Inhibitors Help to Cure HIV?”

• April 2013. Institut Pasteur, Cayenne, French Guyana. “The epidemiology of transmission of HIV drug resistance”.

• May 8, 2013. Conference ACFAS, l’Université Laval, Québec, QC. <<Est-ce que les inhibiteurs d’integrase seront utiles pour guérir le SIDA?>>

• May 17, 2013. Université de Tours, Tours, France. <<L’utilisation des inhibiteurs

d’integrase dans le traitement du VIH>>

• June 1, 2013. Canadian Institutes for Health Research. New investigators forum. “When will we cure HIV?”

• June 21, 2013. National Institutes of Health, Bethesda, MD. Kuan-The Jeang Memorial

Symposium. “Dreaming about a Cure for HIV”

• July 2013. Publish or Perish Workshop. IAS Conference on Pathogenesis. Kuala Lumpur, Malaysia.


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• August 25, 2013. 9th International Retroviral Nucleocapsid Protein and Assembly

Symposium. Montreal, Canada. The State of anti-HIV Therapeutics.

• Sept. 2013. National conference on HIV/AIDS. Quereteiro, Mexico. Can We Overcome HIV Drug Resistance?

• October 2013. HIV Transmission Workshop. Barcelona, Spain. Will HIV Integrase

Inhibitors Prevent HIV Transmission?

• October 2013. Toronto Hospital. HIV Rounds. Is Dolutegravir a Qualitative Different ARV?

• October 2013. St. Michael’s Hospital. Toronto. HIV Rounds. When will we see

resistance against Dolutegravir in first-line therapy?

• November 2013. Saturn conference on HIV drug resistance. Bloemfontein, South Africa. Are We Reaching the Moment of Truth: Can We Cure HIV?

• December 2013. Conference on HIV Reservoirs. Miami, Florida. What If Drug

Resistance against a New ARV Could not Occur?

• December 2013. Ndola, Zambia. TanZamBo Collaboration on HIV. How Can We Prevent HIV Transmission through Use of ARVs?

• December 2013. Mumbai, India. AIDS Society of India. Is It Possible to Prevent HIV

Drug Resistance?

E. Patents Sheppard, Donald Patent: Choe S, Al-Abdallah Q, Sheppard DC. Detection of Arsenic with Fungal Biosensor. Under review US Patent Office. Describes the use of a genetic construct of Aspergillus niger to detect low level contamination of drinking water with arsenic species. US 61/607,868. Status: Provisional

F. Contracts Gotte, Matthias

• Quebec Consortium for Drug Discovery (CQDM)- Operating Grant (PI, Co-I Dr. Guy Boivin, Laval University) Title: Phage-based screening platform for the discovery of antivirals


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Term: (01/10/2010 – 31/09/2013) Amount/year: $ 239,868 (my share)

• Gilead Sciences Inc. - Operating Grant Term: (5/2013 – 10/2014)

Piccirillo, Ciriaco

• GSK Service Contract – Validation of therapeutic adjuvants for breast cancer vaccination • Ebiosciences – Monoclonal development towards novel T cell proteins (human and

mouse) • BD Biosciences – Monoclonal development towards novel T cell proteins (human and

mouse)


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Initiatives and Innovations related to Teaching Programs

A. Graduate Program In 2013, the revised MSc and PhD programs have been implemented with great success. To improve efficiency, the graduate program committee streamlined the operation of the program by designating a member of the committee as coordinator for each program requirements. In addition, to ensure that students have all the information they need to have a successful graduate experience in the department, the Graduate Program Committee produced detailed handbooks for the new programs, which include recommended program timelines to promote on time graduation.

The departmental website for graduate studies has been completely redesigned throughout 2013. The main highlights of the new graduate studies website include:

• A new section dedicated to prospective students

Section III Teaching and Learning


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• A more comprehensive section on financial support policy and possibilities • A new section dedicated to supervisors that provides useful information on program

requirements, guidelines for members of various committees and links to help improving supervisory practices.

• A Useful Links section including links to the new GPS website and to Skillsets The Graduate Program joined a pilot project sponsored by Graduate and Post-Doctoral Studies and the Faculty of Medicine to implement an electronic tracking system for graduate students.

B. Undergraduate Program Undergraduate teaching is one of the primary missions of our Department. Over the past few years, we have engaged in a process of examining and improving our undergraduate curriculum. This process started with teaching retreats in 2010 and 2013, and continued with renewed intensity in the past year by focusing on the courses that make up the immunology ribbon of our undergraduate curriculum.

Leadership

The former (Dr. James Coulton) and current (Dr. Ciro Piccirillo) Chairs of the Undergraduate Committee, as well as members of the committee, have overseen this process. The Department, in conjunction with Teaching and Learning Services (TLS), hired Dr. Claire Trottier as an Education Specialist to facilitate changes to the undergraduate curriculum. Dr. Mariela Tovar (TLS) has also played a key role in facilitating this work. Graduate student Patricia Minor (TLS) provided logistical support.

Our Department’s immunology courses underwent major changes during the 2013-2014 academic year. The course coordinators and lecturers for these classes provided exemplary leadership and contributed tremendous time and effort to achieve these changes, described below in more detail.

MIMM386: Less “cookbook” and more thinking in new immunology laboratory in Winter semester

Dr. Sylvie Fournier, aided by Dr. Trottier, lead a complete redesign of the immunology component of the U2 level laboratory course. This course has traditionally been given over a full year, and will be officially split into a Fall course (MIMM384) and a Winter course (MIMM385) in the 2014-2015 academic year due to the approval we obtained from the Academic Committee in the Faculty of Science. However, MIMM386 was already delivered as two separate sections this past year.

The redesign was targeted to the immunology component given in the Winter semester. The former version of this course featured outdated experiments and used traditional instructional strategies: didactic lectures and guided “cookbook” labs. This course was redesigned to reflect modern scientific methodologies and evidence-based educational approaches to align our learning outcomes with our teaching strategies and assessments. Students performed cell culture, flow cytometry, ELISA and QPCR. We used a problem-based learning approach to allow students to formulate their own hypothesis, and design and carry out their own experiment using


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the reagents at their disposal. Novel assessments included a lab book assessment, a performance-based assessment, an experimental plan, and a poster presentation.

MIMM314: Renewed focus on immune mechanisms and trial use of in-class small group activities

Dr. Ciro Piccirillo coordinates this required U2 course and began a process of renewal of this intermediate immunology course. This intermediate immunology course acts as a bridge between MIMM214 and MIMM314, and now has a renewed focus on key mechanisms in immunology through the exploration of five distinct themes. This includes a theme on human immunology which was absent in the former version of this course, and which fills a growing need for students to learn about human immunology in health and disease. Dr. Piccirillo streamlined the course by reducing the number of lecturers (himself and Drs. Irah King, Sylvie Fournier and Ines Colmegna), each with a specialized focus that build logically on MIMM214 and on one another. This year they began implementing small group activities in the classroom and posting some material for students to review on their own time. This course will continue to undergo changes in the next few years.

MIMM414: Students develop ability to critically read peer-reviewed articles through use of Active Learning Classroom and novel assessments

Dr. Jorg Fritz coordinates this U3 course and led a major redesign guided by the overall learning outcomes for the course, which include that students will be able to critically read and analyze peer-reviewed papers in immunology. He and his three co-lecturers (Drs. Connie Krawczyk, Maziar Divangahi and Sylvie Lesage) used the Active Learning Classroom to break students into small groups and engage them in a series of in-class activities designed to build the skills required to read, understand and critically appraise scientific data and published papers. They used novel assessment methods to assess student learning of the specific course learning outcomes.

MIMM509: Implementation of new assessment rubrics

Dr. Joyce Rauch coordinates this upper-level seminar course in immunology. This year, she implemented the use of new grading rubrics to streamline the assessment process and provide more regular feedback to the students regarding their performance in the course.

Looking ahead at the Undergraduate Program

The changes made to the immunology stream have been substantial, and we will continue to examine and modify this stream over the next few years. We plan to begin a process of reflection on the microorganism stream in the upcoming year.

C. Success Stories for Our Trainees Fikregabrial Aberra Kassa, received the Canadian Society for Immunology (CSI) and the Centre for Host Parasite Interaction (CHPI) travel awards to present his research at the 15th


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International Congress of Immunology in Milan, Italy from August 22-27. The awards total is $2,500. Natan Bensoussan, won the Canadian Society of Microbiologists Undergraduate Award. He received an award for $500. Dr. Sophie Fougeray, received “Le Prix pour les jeunes chercheurs” from the Bettencourt-Schueller Foundation to finance the first year of her Post-doctoral studies. Dr. Sophie Fougeray, a Post-doctoral fellow received the “Laureate des prix solennels de la Chancillerie des Universités de Paris pour l’année 2013. Maria Gentile, a MIMM U2 student for being awarded a “Student Summership” from the Canadian Association of Gastroenterology. Daisy Ji, won the Governor General’s silver medal. Laura Isobel McCall, was selected to give a presentation “3 Minutes to Change the World”. Panagiotis Mitsopoulos, received the Seahorse Bioscience Travel Award to present his research at the American Association of Immunologists- Immunology 2013. The award amount is $750. Olivier Papapietro, a Post Doctoral Fellow won “The Best Poster” award at the 2nd Annual Canadian Human and Statistical Genetics Meeting which was held in Esterel, Quebec April 21-24. Adam Peres, received the Neuroinflammation CIHR Strategic Training Program Travel Award to present his work at the American Association of Immunologists-Immunology 2013. The award amount is $2000. Mohammed Rabbani was awarded the Canadian Foundation for Infectious Diseases, CFID Award. The amount of award is $4000. Daegan Sit and Joseph Yang, won 2nd prize at the 9th Annual Undergraduate Research Conference. Tom Ying, won second place in the Ontario Quebec Undergraduate Immunology Conference (OQUIC).

D. List of Students who received M. Sc. Degrees

Student Thesis Title Supervisor Padda, Ranjit “Impairment of iron

homeostasis and lipid metabolism in Hemojuvelin

Dr. Konstantinos Pantopoulos


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knockout (Hjv-/-) mice in response to high fat diet”

Rainone, Anthony “Neuropathy in a mouse model of CD8+ T cell- mediated CNS demyelination”

Dr. Sylvie Fournier

Rickard, Jenaya “Development of FRET-based assays to characterize the HCV NS5a homodimerization and its interaction with RNA”

Dr. Matthias Gotte

Thomson, Cassandra “The HIV-1 protein Nef disrupts T cell receptor signalling and thymic function”

Dr. Paul Jolicoeur; Dr. Ciriaco Piccirillo

McCallum, Matthew “Mutational bias and emergence of drug resistance in the human immunodeficiency virus type 1”

Dr. Mark Wainberg

Paradis, Maude “Regulation of B cell responses by Nod1-mediated peptidoglycan recognition”

Dr. Jörg Fritz

E. List of Students who received Ph. D. Degrees

Student Thesis Title Supervisor Biondi, Mia “From the notorious to the

novel: Identifying and characterizing mutations in HIV-1 reverse transcriptase and integrase”

Dr. Matthias Gotte; Dr. Michael Reed

McCall, Laura-Isobel “Parasite and host determinants of visceral leishmaniasis”

Dr. Greg J Matlashewski

Donahue, Daniel “The role of viral reservoirs in HIV-1 infection”

Dr. Mark Wainberg

Lorgeoux, Rene-Pierre “Multiple roles of DDX17 in human immunodeficiency virus type 1 replication”

Dr. Chen Liang

Samuel, Sara “Vesicular stomatitis virus and BCL-2 inhibitor combination therapy for the treatment of chronic lymphocytic leukemia”

Dr. John Hiscott; Dr. Rongtuan Lin


35

Thanabalasuriar, Ajitha “Functional characterization of the bacterial virulence factor NleA”

Dr. Samantha Gruenheid

Dallaire LeBlanc, Philippe “Novel functions of the inflammatory caspases”

Dr. Maya Saleh

Daniels, Sylvanne “TRBP as a target for HIV-1 mediated suppression of RNA interference”

Dr. Anne Gatignol

Gigoux, Mathieu “The role of inducible costimulator-mediated phosphoinositide 3-kinase activation in the differentiation and function of follicular helper T cells”

Dr. Woong-Kyung Suh

Thomassin, Jenny-Lee “Antimicrobial peptide resistance mechanisms used by Enteropathogenic and Enterohemorrhagic «Escherichia coli»”

Dr. Samantha Gruenheid; Dr. Herve Le-Moual

F. Data on Departmental Activities

See Appendixes: Tables 1 to 4

G. List of Seminar Guest Speakers in the Infection and Immunity Seminar Series from January to December 2013

DATE

SPEAKER

TITLE

January 10, 2013 Dr. Sebastien Faucher Department of Natural Resource Sciences, Faculty of Agricultural and Environmental Sciences, McGill University, Macdonald Campus

“Genetic determinants of the survival of Legionella pneumophila in water”

January 24, 2013 Dr. Subburaj Ilangumaran University of Sherbrooke

“Priming of CD8+ T lymphocytes by inflammatory cytokines: Implications for Autoimmunity and Tumor immunotherapy”

February 7, 2013 Dr. Nathalie Arbour Université de Montréal, Research Center (CHUM)

“Dialogue between T Cells and brain cells in the context of multiple sclerosis”


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February 21, 2013 Dr. Bana Jabri Department of Medicine and Pediatrics, University of Chicago

“TLR2: The Janus of toll-like receptors”

March 7, 2013 Dr. Gauchat Jean-Francois Université de Montréal

“The roles of IL-30 and cardiotrophin-like cytokine in T and B cell differentiation”

March 21, 2013 Dr. Sam Miller University of Washington

“Using bacteria to understand human innate immune diversity”

April 11, 2013 Dr. Maria Ciofani University of New York

“The transcriptional regulatory network governing Th17 cell specification and plasticity”

April 18, 2013 Dr. Thomas Schlich McGill University

“A realignment of surgery and laboratory science: asepsis and bacteriology, 1880-1900”

May 2, 2013 Dr. Hartmut Wekerle Max Planck Institute of Neurobiology, Martinsried

“Thymus – gut – lung – spleen - brain (and back?) – The improbable journey of a brain autoimmune T lymphocyte”

September 5, 2013 Dr. Samantha Gruenheid Department of Microbiology and Immunology, McGill University

“Career Day”

September 19, 2013 Dr. Marie-Laure Santiago-Raber Medical School of Geneva, University of Geneva

“Endosomal TLRs and B cells investigations in animal models of autoimmunity (Lupus and EAE)”

September 27, 2013 Dr. Francois Campbell-Valois Institut Pasteur, Pathogénie Microbienne Moléculaire

“Seeing Type Three Secretion Apparatus activity: what it means for effectors function in Shigella flexneri?"

October 3, 2013 Dr. Greg Matlashewski Department of Microbiology and Immunology, McGill University

“Elimination of Visceral Leishmaniasis through Implementation Research”

October 17, 2013 Dr. Tyler Reddy Oxford University

“Biophysical characterization of full-scale influenza virions, dengue virions, and class III viral fusion proteins”

October 24, 2013 Dr. Marc Ouellette Canadian Institutes of Health

“Gene copy number matters in antimicrobial resistance”


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Research Institute of Infection and Immunity

November 7, 2013 Dr. Albert Descoteaux Centre INRS – Institut Armand - Frappier

"Alteration of the host cell membrane fusion machinery by the protozoan parasite Leishmania"

November 21, 2013 Dr. Juliana Yeung Simon Fraser University

"A novel sialidase in the opportunistic fungal pathogen, Aspergillus fumigatus"

December 5, 2013 Dr. Nicole Baumgarth Center for Comparative Medicine, University of California

“Innate-like B cells in infection, their functions and their rules of engagement”

December 19, 2013 Dr. Ciriaco Piccirillo Department of Microbiology and Immunology, McGill University

“Foxp3+ regulatory T cells in health and disease: from mechanism to biomarker discovery”


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Section IV Academic & Community Service


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Successful fundraising Through a coordinated effort with the Faculty of Science, the Department fo Microbiology and Immunology was abel to outreach our alumni and friends through a broad array of activities. These resulted in the following three frundraising sucesses: a) Wares Family Fellowship: a $50,000 donation over the next 5 years has been allocated to a

PDF working with a MDTC member. This $10,000/year fellowship helps to reduce the supervisor’s financial load and is granted according to merit of the applicant and research project. Our first recipient will be awarded the Fellowship as of June 1, 2014;

b) The Ralph Steinman Science Undergraduate Research Award: thanks to the tireless efforts of

Mr. Seymour Steinman and Dr. Joaquin Madrenas, the Ralph Steinman SURA was finalized in spring 2013 and provided an endowment of just over $170,000 to the unit. The SURA offers 2 undergraduate students a summer research studentship in the laboratory of a Departmental member;

c) Muriel Radcliffe (Lennard) bequeath: in December 2013, a generous contribution was

bequeathed by Ms. Muriel Radcliffe (nee Lennard). This gift has been allocated towards various initiatives, including a plan to provide some seed funding to new projects developed by MDTC members. The money has also gone to the establishment of a new boardroom within the departmental offices to address meeting room need for academic meetings for graduates, lab meetings, etc.

Grade 3 students’ visit to MIMM On April 19 at noon we welcomed 30 students from F.A.C.E. school. The visit started off with a historical overview tour of the building followed by an interesting talk about “Microbes and Human Health” given by Dr. J. Madrenas. The Kids had the opportunity to take part in child-oriented lab activities. This visit is part of an initiative aimed at reaching out to our community and getting young people interested and excited about science. Special thanks to all the volunteers who facilitated this visit: T. Abray, R. Arthur, M. Babiak, I. Ghobri, A. Rainone, A. Zamani & S. Zhang. Outreach Visit to ECS School, April 29 Since 2005, part of the Annual activities of the International Day of Immunology is an “Outreach Visit to Miss Edgar's & Miss Cramp's School, ECS. Alborz Borjian, an M.Sc. student in Immunology and Cynthia Kanagaratham, a Ph.D. student in Human Genetics went to talk to grade 9 students at ECS about allergic reactions, and about immunology. Through a PowerPoint presentation and an open discussion, McGill graduate students were able to explain some myths about different types of allergies and the human immune system, as well as what it means to be a graduate student in the field of Immunology and Microbiology.

Selected Community Involvement Briedis, Dalius

• Reviewer for Journal of Infectious Diseases • Reviewer for Clinical Infectious Diseases


40

Coulton, James • International Union of Crystallography IUCr 2014 meeting, Montreal, August 2014:

active member of Local Organizing Committee • NSERC CREATE, Université de Montréal: executive member • McGill representative to Canadian Society of Microbiologists, January-June 2013 • Biochemical Society (UK): International ambassador • Deutscher Akademischer Austauschdienst, Canadian liaison • Alexander von Humboldt Foundation, Bonn: executive member, Canadian Association

Cousineau, Benoit • NSERC grant reviewer • FRQS Salary Award Committee Member (Chercheur/Boursier Junior I, Fondamental et

Clincien)

Fournier, Sylvie • Reviewer for NSERC ; MS Society of Canada • Member of Quebec-Ottawa Regional Research and Training Centre of the endMS

Research and Training Network

Fritz, Jorg • Reviewer of Journals: Cell Host and Microbes, Infection & Immunity, Molecular & Cell

Biology, American of Respiratory and Critical Care Medicine, PLos One, Vaccine • Editorial Board- Academic Editor - PLos One • CIHR Committee Reviewer – HDK

Götte, Matthias • Editorial board member: Journal of Biological Chemistry, Antimicrobial Agents and

Chemotherapy • NIH Study Section on AIDS Discovery and Development of Therapeutics • FRSQ – Career Award Junior 1 • Reviewer NIH, Laboratory of Molecular Pharmacology

Gruenheid, Samantha • Review editor, Frontiers in Cellular and Infection Microbiology, May 2010-present • External member, hiring committee for academic position in Host-Pathogen Interactions.

Institute Armand Frappier 2013-14 • Session co-chair Canadian Society of Microbiologists Annual Meeting 2013 Infection

and Immunity Session

King, Irah


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• Reviewer for France-Canada Research Fund (FCRF) competition • Chair of the ACTRIMS/CHIN supported FOCIS member society symposium on

neuroimmunology, June 27, 2013, FOCIS meeting, Boston, USA.

Krawczyk, Connie • Organizer: MIMM Career Day, FlowRNA (Ebiosciences) October 17, 2013

Le Moual, Herve • Saskatchewan Health Research Foundation, 1 grant application, June 2013. • Member of the NSERC 1501 Research Tools and Instruments evaluation committee. • Member of the FRQNT Microbiology evaluation committee # 29. • Membre des comités d’évaluation de trois professeurs, Centre INRS-Institut Armand-

Frappier, 19 Mars 2013.

Madrenas, Joaquin • Executive Director, Canadian CIHR Human Immunology Network • Director, Microbiome and Disease Tolerance Centre • Member, Medical Review Panel of the Canada Gairdner Foundation Awards • Member, Board of Directors of ImmunoMontreal • Member, Alberta Innovates – Health Collaborative Reseach and Innovation Opportunities

Review Pannel. • Member, External Review Committee for the Department of Microbiology and

Immunology, University of British Columbia • Co-organizer, CIHR Human Immunology Network-Canadian Society of Immunology

Symposium on Lung Immunology, Whistler, BC, April 7, 2013. • Leader and co-organizer of the National Café Scientifique Sessions on 2013 International

Immunology Day (April 29, 2013) (sessions in Halifax, Montreal, Toronto, Hamilton, London ON, Winnipeg, Calgary, Edmonton, Vancouver, organized by local nodes).

• Chair, Pathogens and Host Defense Block Symposium, Annual Meeting of the American Association of Immunologists, Honolulu, HA, May 7, 2013.

• Member, Organizing Committee, Tissue-intrinsic mechanisms of immunoregulation: neuroinflammation and beyond. A Jointly ACTRIMS/CIHR Human Immunology Network Sponsored Satellite Symposium of the 2013 FOCIS International Meeting, Boston, MA, June 27, 2013.

Marczynski, Greg • Tenure package reviewer for the Université de Lausanne (UNIL), Lausanne, Switzer-land

(external).

Matlashewski, Greg


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• Advisory panel member; Research priorities for the elimination of visceral leishmaniasis. World Health Organization, Freiburg, Germany, Sept. 24, 2013

• CIHR Panel Member: Microbiology and Infectious Diseases panel.

Murgita, Robert • Member of the editorial board of the following journals: Journal of Immunology and

Clinical research, Journal of Microbiological Methods, Journal of Autoimmunity and Cell Responses, Journal of Immunology and Clinical Research

Olivier, Martin • Conference Organization: Member of the Selection Committee for the WorldLeish 5

meeting in Brazil and symposium organization (2011-2013) • Member of the local organizing committee (LOC), The Neutrophil in Immunity,

Montréal, Canada. (September 2012 - June 2014) • Session Chair: Chairman of Experimental Immunology Symposium, WorldLeish 5, Porto

de Galinhas, Pernombuco, Brazil. (May 2013) • Chairman of the Immunology Symposium, ASP/CHPI Annual meeting, Quebec City,

Canada (June 2013) • Chairman of Workshop on “Immunity to Bacterial Infection (excluding mycobacteria)” • 15th International Congress of Immunology, Milan, Italia. (August 2013) • Radio Interview: 98,5 FM Radio, Interview in regard to the new vaccine using

Plasmodium sporozoite (August 2013) • Guest Section Editor, PLoS Pathogens (2013)

Piccirillo, Ciriaco • JDRF Center review panel • NIAID Special Emphasis Panel: Investigator Initiated Program Project Applications

(P01) • NIAID Autoimmunity Centres of Excellence (ZAI1 PA-I (J1) • Fondazione Cariplo (Milan, Italy) • Broad Foundation • Canadian Diabetes Association • Organization of Café Scientifique (CHIN/Immuno-Mtl co-sponsored) • Academic Editor, PLoSONE • Editorial Board, World Journal of Diabetes, Frontiers in Immunology, International

Trends in Immunology, American Journal of Clinical and Experimental immunology • Elected Chair (2013-2015): Community of Practice for FOCIS • Establishment of the Teaching Research Excellence to Girls (TREG) Program at Sacred

Heart High School, destined to raise awareness of high-achieving girls to the importance biomedical research in society.

• Keynote Speaker at 2013 Golf Tournament to fundraise for T1D Research.

Sheppard, Don • Member, CIHR Microbiology and Infectious Diseases Panel (2days) • Member, FRSQ Junior II Chercheur Boursier, Chercheur Clinicien Panel (2days)


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• Guest Editor, PLoS Pathogens • Editorial Board, Fungal Genetics and Biology • Chair, Awards Committee, Association of Medical Microbiology and Infectious Diseases

of Canada (10h) • Scientific Committee, 6th Advances Against Aspergillosis Conference, (4h) • ESCMID Clinical Practice Guidelines for Management of Invasive Aspergillosis

Workgroup (2 days) • ESCMID Advisory Workgroup for the management of drug resistant Aspergillus

infections (2 days) Wainberg, Mark

• Co-Editor-in-Chief Retrovirology • Co-Editor-in-Chief Journal of the International Aids Society • Executive committee member International Union of Microbiology Societies, Montreal,

2014 • Executive committee member International Conference on HIV/AIDS Pathogenesis

Vancouver 2015 • Director, McGill Univ. AIDS Centre


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Section V Consulting Activities


45

Faculty Member Private Sector Consulting

Public Sector Consulting Total

Dr. Ciriaco Piccirillo ProScan, Alcimed, Deveau et associes, Cariplo Fnd, Broad Foundation

CIHR, NIH, Austrian Science Foundation, Agence Nationale de la Recherche de France

23.5h

Dr. Joaquin Madrenas Alberta Innovates – Health Collaborative Reseach and Innovation Opportunities Review Pannel. Board of Directors of ImmunoMontreal

48h

Dr. Donald Sheppard Merck Global, Pfizer Canada, GSK Europe, Astellas Canada

4h


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APPENDIXES

TABLE 1. UNDERGRADUATE STUDENTS GRADUATIONS WINTER 2013, SPRING 2013, FALL 2013

Winter 2013 Spring 2013 Fall 2013

Liberal 1 Liberal 3 Liberal 2

Honours 0 Honours 15 Honours 0

Majors 4 Majors 35 Majors 6

IHI 15 IHI 1

5

68

9

TOTAL 82

TABLE 2. TOTAL GRADUATE DEGREES GRANTED OVER THE PAST 4 YEARS

Winter 2013 Spring 2013 Fall 2013 registered graduated registered graduated registered graduated M.Sc. 20 4 21 0 27 4 Ph.D. 43 3 41 2 38 8 TOTAL 63 7 62 2 65 12

Winter 2012 Spring 2012 Fall 2012 registered graduated registered graduated registered graduated M.Sc. 25 6 22 4 22 6 Ph.D. 46 1 45 3 44 4

TOTAL 71 7 67 7 66 10


TOTAL 70 6 70 5 73 6


TOTAL 78 10 74 5 73 7

TABLE 3. GRADUATE STUDENT ENROLMENT AND FUNDING 2007-08 2008-09 2009-10 Fall

2010 2011 2012 2013

Total Number of:

Graduate Students 75 85 78 72 74 68 63 Number of New 26 33 25 13 22 15 18 Graduate Students Average CGPA of 3.46 3.49 3.66 3.65 3.76 3.53 3.48 Incoming Students Fellowships/ Scholarships/Awards/ $697,410 $747,345 $1,066,902 $710,685.43 $348,922.88 $349,517.30 Bursaries Teaching/ Demonstratorships/ $74,104 $78,877 $101,876 $52,611.64 $68,465.40 $63,334 Service Student Stipends $713,350 $922,900 $1,398,486 $1,035,422.63 $921,360.39 620,152.55 Total Funding $1,484,863 $1,749,122 $2,567,265 $1,818,790.88 $1,338,748.67 $1,033,003.81 Average Funding per $29,227/19 mths* Registered Trainee $19,798 $20,578 $18,459 $20,208.78 $20,284.00 $16,396.88 per annum Number of Post-‐doc's 9 (2013)

TABLE 4. FUNDING OF GRADUATE STUDENTS BY SOURCE

A. Departmental Awards F.C. Harrison Fellowships 8 $20,280.00 Dr. Jacob Rozanis Fellowship 4 $9,478.00 W. Yaphe Award 4 $1,400.00 Graduate Student Research Day 7 $1,550 TOTAL 23 $32,708.00 B. Internal Funding Differential Fee Waiver 3 $24,800 Graduate Excellence Fellowship (GEF's) 37 $168,000 Student Stipends 42 $620,152 Teaching/Demonstrators/Service 20 $63,334 The Great Travel Awards 9 $5,500 TOTAL 111 $881,786

C. External Fellowships TOTAL 9 $101,459.26 GRAND TOTAL 143 $1,015,953.00

2013 annual report v5 - mcgill university · research successes included 78 publications in high...

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