2015 ANNUAL MEETING OF THE HENRY KUNKEL SOCIETY

Inflammation and Autoimmunity

Centre des PensièresAnnecy, FranceApril 14–16, 2015

Henry George Kunkel

1916–1983

H enry Kunkel received his B.S. degree from Princeton and his M.D. degree from Johns Hopkins University. He arrived at The Rockefeller Institute (now University) in 1945 where he spent his entire scientific career until his death in 1983. His contributions to the field of basic and clinical immunology are legendary. He

made numerous seminal observations in liver disease, rheumatic diseases and other allied disorders.

He was perhaps best known for his pioneering and extensive studies on the immunoglobulins. His recognition thatmyeloma proteins were a model for the study of the structure of normal immunoglobulins had a global impact on investigations of the structure, function and inheritance of these molecules. The elucidation of the chain structure of gamma globulin and the recognition that immunoglobulins possessed individual antigenic specificity (idiotypes) were internationally recognized discoveries.

Dr. Kunkel was the recipient of many awards and honors, including membership in the National Academy ofSciences, honorary degrees from Universities of Uppsala and Harvard, and recipient of the Lasker and Gairdner Awards and the Kovalenko Medal of the National Academy of Sciences.

Henry Kunkel Society Officers Henry Kunkel Society Lecturers

President ..........................Keith Elkon Jean-LaurentVice President ...................... CasanovaSecretary ..... Anne Marshak-RothsteinTreasurer ........................... Eric Meffre

1992...............................Louis Kunkel1993.................................... David Ho1994.........................Benvenuto Pernis1996............................Jeffrey Ravetch1997.............................Anthony Fauci1998...........................Klaus Rajewsky1999..............................Peter Doherty2000...........................Max D. Cooper2001............................. Fritz Melchers2002............................. Tasuku Honjo2003..................................Fred Rosen

2004.............................. Diane Mathis2005....................... Charles Weissman2006..................... Ralph M. Steinman2007.................Antonio Lanzavecchia2008............................. John Atkinson2009............................Thomas Tuschl2010............................... Frederick Alt2011........................... Mark M. Davis2012.......................... Louis M. Staudt 2013........................ Daniel L. Kastner2014........................Shigekazu Nagata

Henry Kunkel Society Members

Gyorgy Abel Sergio AbrignaniLuciano AdoriniVincent AgnelloIrma AiroldArne N. AkbarDonato Alarcon-Segovia#

Matthew AlbertMara Luisa (Marisa) AlegreKonstantina AlexandropoulosPaul AllenChester A. AlperSebastian AmigorenaUlf AndersonPaul J. AndersonFrancesco AnnuziatoWilliam P. ArendJoseph R. ArronJohn P. AtkinsonK. Frank AustenStratis AvrameasRaffaele BadolatoDavid BahlerVincenzo BarnabaBetsy Barnes† Craig BassingAntony BastenEkkehard K. F. BautzAlexander Bearn#

Timothy W. BehrensBaruj Benacerraf#

J. Claude BennettChristophe O. BenoistDon Benson†

Zvi BentwichClaudia BerekKâre BergIra BerkowerRobert D. Bigler, IIBryce Binstadt†

Richard S. BlumbergLinda K. BockenstedtBjarne BogenGilles BoireCatherine BollardStefano BombardieriConstantin A. BonaJerry BossMarina BottoVassiliki A. BoussiotisJean-Pierre BouvetJoseph BoyleThomas J. BracialeFerdinand C. BreedveldSamuel Breit†

Michael BrennerStanley Louis BridgesThomas BrockerEric BrownTeodor-Boru BrumeanuYenan Bryceson†

Richard Bucala†

Steven BurakoffGerd-Rudiger BurmesterJoel BuxbaumJill BuyonEdit BuzásJohn C. ByrdMichael CahalanFederico Caligaris-CappioMichael P. CancroDaniela CapelloJ. Donald Capra#

Ronald I. CarrMichael C. CarrollRobert H. CarterPaolo CasaliJean-Laurent CasanovaRafael CasellasMichael CentolaAnthony CeramiAndrea CeruttiEthel CesarmanEdward K. L. ChanAndrew ChanGeorge K. ChandyLucienne ChatenoudTalal ChatilaTriantafyllos ChavakisYouhai ChenSelina Chen-KiangNicholas ChiorazziFrancis V. Chisari

Carlo ChizzoliniCharles ChristianCharles ChuMarcus Ramsay ClarkEdward A. ClarkRachael ClarkCharles CochraneMichel CognéRichard CoicoMary Ellen ConleyGabriela ConstantinH. Terence CookDavid CooperMax D. CooperAndrew P. CopeJoseph CraftCarlo M. CroceAlan CrossMary K. CrowYanick CrowCharlotte Cunningham- RundlesRiccardo Dalla-FaveraRajendra DamleFranco DammaccoRobert B. DarnellAnne DavidsonRandall S. DavisNoorbibi K. DayJean-Michel DayerSilvia Deaglio

Paolo DellabonaStephen V. DesiderioKavita DhodapkarMadhav V. DhodapkarBetty A. DiamondHoward DicklerGuillermo DighieroTeresa P. DiLorenzoWalter H. DoerflerPeter C. DohertyThomas DörnerDaniel DouekSteven DouglasTerry William Du ClosAnne DurandyGeorge EbersDimitar G. EfremovMichael EhrensteinGötz EhrhardtKlaus EichmannRobert A. EisenbergHani El-GabalawyKeith ElkonAnna ErdeiDoruk ErkanLuis R. EspinozaPaul EvansZsuzsa FabryAndras FalusDonna L. FarberA. Darise FarrisC. Garrison FathmanDouglas Thomas FearonTen FeiziMarc FeldmannGianfranco FerraccioliManlio FerrariniErol FikrigTerri FinkelAlison FinneganGary S. FiresteinVincent FischettiZvi FishelsonDavid E. FisherKate Fitzgerald† Richard A. FlavellThomas A FleisherFrancesco ForconiIra J. FoxMarvin FritzlerYang-Xin Fu FuShu Man FuHerman FudenbergSarah L. GaffenPatrick GaffneyGianluca GaidanoThomas F. GajewskiUri GaliliIgnacio Garcia-De La TorreHubert Baburaj (Bobby) GasperRaif S. GehaFrédéric Geissmann†

James L. German, IIIM. Eric GershwinPaolo GhiaAllan GibofskyIrma GigliGray Steven GilkesonMartin John GlennieLaurie GlimcherOtto GoetzeLeslie GoldRaphaela Goldbach-ManskyRobert A. Good#

Tom GordonSiamon GordonJorg J. GoronzyEmil C. GotschlichSusan R. S. GottesmanAlice B. GottliebEllen M. GravalleseArthur GrayzelMark GrebenauMark I. GreeneHoward M. GreyBodo GrimbacherLuca GuidottiSudhir GuptaDavid A. HaflerKathleen A. HainesWilliam W. HallSophie HambletonLennart HammarstromLars HansonMorten HarboeJohn A. HardinDavid M. HarlanJohn B. HarleyJeffrey HasdayDorian HaskardBarton HaynesPeter HensonKevan C. HeroldRafael Herrera-EsparzaMartin HerrmannIngrid Birgitta HeymanFalk HiepeAdrian HillJules HirschRichard J. HodesV. Michael HolersSteven M. HollandHalsted R. HolmanDavid HornAlan N. HoughtonThomas W. J. HuizingaMary Beth HumphreyJohn Hurley#

David A. IsenbergKimishige IshizakaLionel B. IvashkivBana JabriHans-Martin JäckChaim Oscar JacobIsraeli JaffeAshish JainJudith A. JamesRoland JonssonDieter KabelitzJoachim R. KaldenInsoo KangGilla KaplanMariana Kaplan†

Mikael KarlssonJonathan D. KatzMichel D. KazatchkineJack D. KeeneRobert KimberlyPaul W. KincadeThomas KindtTe Piao KingMichael KirschfinkLars KlareskogKim L. KlineGlen KnightDaniel M. KnowlesHon-Sum KoAlisa E. KochDavid Koffler#

Frits KoningDwight H. KonoPhilippe H. A. KourilskyMichael KrangelRichard KrauseKarsten KretschmerJames G. KruegerVijay KuchrooDinakantha KumararatneSteven KunkelLouis KunkelAntonio La CavaPeter J. LachmannRobert G. LahitaAntonio LanzavecchiaTerri LauferJeffery A. LedbetterDavid M. LeePaul J. LehnerMichael J. LenardoBeth LevinePeter LipskySergio A. LiraGary W. LitmanStephen LitwinYang LiuMiguel Lopez-BotetTheresa Lu†

Pier Luigi Luigi MeroniXiaojing MaCrystal L. MackallRavinder N. MainiFabio MalavasiMark J. MamulaMart MannikAlberto MantovaniMarkus G. ManzJohn J. MarchalonisFrancesco M. MarincolaJoseph A. MarkensonAnn Marshak-RothsteinAna MartinezGiuseppe MatareseDiane J. MathisLloyd MayerMaclyn McCarty#

James McCluskeyJoseph (Mike) McCuneA. McGehee HarveyVictor McKusickRuslan MedzhitovEric MeffreEdgar Meinl† Fritz MelchersElizabeth D. MellinsHenri MenardMiriam MeradPier Luigi MeroniJoan T. MerrillJiri MesteckyChristine MetzDror MevorachMary Ann MichelisPeter A. MiescherFred MillerEric C. B. MilnerJoshua MilnerToshihide MimuraSeiji MinotaPierre MiossecChandra MohanTom Eirik MollnesPatricia K. A. MonginiLaurence MorelLorenzo Moretta

Jane Morse#

Bernard MoserWilliam A. MullerHans Muller-Eberhard#

Kenneth MurphyPhilip M. MurphyNatarajan MuthusamyBertrand NadelLaszlo Nagy† Carl F. NathanJacob B. NatvigGerald Thomas NepomTimothy Niewold† Janko Nikolich-ZugichKenneth NilssonFalk NimmerjahnDouglas F. NixonGustav J. V. NossalLuigi D. NotarangeloJan NovakVictor NussenzweigMichel C. NussenzweigHans D. OchsLloyd OldMichael B. A. OldstoneEugene OltzJordan Scott OrangeAnders OrnBarbara Anne OsborneC. Kirk OsterlandMario A. OstrowskiShoichi OzakiStephen A. PagetSavita PahwaEric G. PamerSunpho ParkVirginia PascualDhavalkumar D. PatelAndras PerlPeter PerlmannAlessandra Pernis† Benvenuto PernisErik PetersonRodney Ernest PhillipsRichard PhippsMatthew PickeringDavid S. PisetskyVito PistoiaK. Michael PollardRichard M. PopeDavid N. PosnettRobert PrendergastLuminita PricopJennifer PuckAnne Puel† Chaim PuttermanLluis Quintana-MurciAndreas RadbruchMarko Z. RadicKanti R. RaiKlaus RajewskyJoyce RauchJeffrey RavetchStanley ReadAnn ReedWestley H. ReevesMorris ReichlinBernardo Reina-San MartinBoris Reizis† Maria RescignoMichael RethLisa G. RiderFrederic Rieux-LaucatWilliam C. RobbinsWilliam Robinson

PROGRAM

TUESDAY, APRIL 14, 2015

3 p.m. Council Meeting

5:30 p.m. Welcome: Alain Mérieux, Président, Institut Mérieux Jean-François Bach, Secrétaire perpétuel, Académie des Sciences

Introduction: Keith Elkon, President, the Henry Kunkel Society University of Washington, Seattle, WA, USA

6 p.m. Annual Henry Kunkel Society Lecture: Yanick Crow (Member) Institut Imagine, University René Descartes, Paris, France and University of Manchester, UK Human Type I Interferonopathies — An Update

7 p.m. Cocktail Reception

8 p.m. DinnerCentre des Pensières

Toby RodmanMartin RodriguezSantiago Rodriguez de CordobaAxel RoersChristopher Roman Lars RönnblomDerry Roopenian† Antony RosenFred Rosen#

Hugh RosenAgueda A. RostagnoCarla Rothlin† Thomas RothsteinRobert A. S. RoubeyRobert L. RubinAlexander Y. RudenskyCarlo RussoFederica SallustoJane E. SalmonHugh A. SampsonInger SandlieMatyas SandorLaura SantambrogioIgnacio SanzMinoru SatohDavid SchatzGeorg SchettClaudine SchiffReinhold SchmidtRobert SchreiberHarry W. Schroeder, Jr.Peter H. SchurHans-Wilhelm SchwaebleR. Hal ScofieldGavin ScreatonBenjamin M. SegalAndrey ShawBarbaray Sherry

Yufang ShiMark Jay ShlomchikFrederick P. SiegalLeslie E. SilbersteinGregg SilvermanRoy L. SilversteinFranco SilvestrisAlfred SingerRam SinghFrancesco SinigagliaJohn Patrick SissonsMarjorie SlankardBarry SleckmanKendall SmithKenneth G. C. SmithAgata Smogorzewska†

Josef SmolenScott SnapperEric SobelLudvig M. SollidAlan SolomonSilvano SozzaniDavid SpanerKostas StamatopoulosLouis StaudtBettie M. SteinbergRalph M. Steinman#

Freda K. StevensonJoseph St. Geme IIIWilliam StohlHelen Su† Kathleen SullivanYoshinari TakasakiToshitada TakemoriNorman TalalEng M. TanStuart TangyeAlexander TarakhovskyKristin Tarbell

Naomi TaylorFrancesco TedescoCox TerhorstArgyrios N. TheofilopoulosRobert ThoburnAdrian ThrasherJoshua Thurman† Angela TincaniJenny Ting† Thomas TomasiKevin J. TraceyElisabetta TraggiaiEdward L. TreadwellGiorgio TrinchieriJurg Tschopp#

George TsokosNaoyuki TsuchiyaShannon TurleyKenneth TylerAntonio UccelliJonathan W. UhrRaivo UiboEmil R. UnanueDerya UnutmazJacques UrbainPaul J. UtzAnders G. VahlneAndrea VambutasWesley C. Van VoorhisCharles S. ViaAnna VillaHerbert W. VirginUlrich H. Freiherr von Andrian-WerburgHarald von BoehmerMarie Wahren-Herlenius† Takaji WakitaThomas A. WaldmannHerman Waldmann

Mark Jeremy WalportJeremy Walston† Chang-Yi WangJingsong WangH. Shaw WarrenRichard L. WassermanMartin WeigertJean-Claude WeillMarc WekslerHans Ulrich WeltzienPeter P. WernetPer WestermarkCornelia M. WeyandJuergen WienandsDavid WiestRalph C. Williams, Jr.Patrick C. WilsonRobert J. WinchesterJohn WinfieldJedd WolchokKevin WoollardKai W. WucherpfennigRamnik XavierKazuhiko YamamotoWilliam YountJohn ZabriskieDebra Jeske ZackHabib ZaghouaniJianying ZhangShen-Ying Zhang† Maurizio ZanettiPan ZhengSong Guo ZhengRolf ZinkernagelYong-Rui ZouMoncef ZoualiJuan Carlos Zuniga-Pflucker

† New member # Deceased

WEDNESDAY, APRIL 15, 2015

8 a.m. Welcoming Remarks Keith Elkon

8:15–10:25 a.m. Session I: Microbiome and Immunity Chairs: Vijay Kuchroo, Ellen Gravallese

8:15 a.m. Andrew Macpherson (Invited Speaker) University Hospital, Bern, Switzerland Stratification of Intestinal Microbes

8:40 a.m. Christophe d’Enfert (Invited Speaker) Pasteur Institute, Paris, France The interplay between Candida albicans, the Microbiota and Mucosal Immunity

9:05 a.m. Frédéric Geissmann (New Member) King’s College London, London, UK Differentiation and Functions of Macrophages

9:25 a.m. Michel Gilliet (Invited Speaker) University of Lausanne, Switzerland Antimicrobial Peptides in Skin Immunity and Autoimmunity 10 a.m. Coffee break

10:30 a.m.–12:15 p.m. Session II: Innate Immune Networks Chairs: Westley Reeves, Cem Gabay

10:30 a.m. Daniel B. Stetson (Invited Speaker) University of Washington, Seattle, USA Nucleic Acid Detection in Host Defense and Autoimmunity 10:55 a.m. Eicke Latz (Invited Speaker) University of Bonn, Germany Sensing the Environment — Activation Mechanisms of the NLRP3 Inflammasome

11:20 a.m. Veit Hornung (Invited Speaker) Institute of Clinical Chemistry and Pharmacology, University of Bonn, Germany Intracellular DNA Sensing Mechanisms in Innate Immunity

11:45 a.m. Ellen Gravallese (Member) University of Massachusetts Memorial Medical Center, Worcester, USA Role of DNA Sensors in the Regulation of Bone

12:30 p.m. Lunch

1:30–3 p.m. Session III: Th17 Cells and Inflammation Chairs: Jacob Natvig, Jean-Michel Dayer

1:30 p.m. Vijay Kuchroo (Member) Brigham and Women’s Hospital, Boston, USA Transcriptional Network Regulating Development of Tregs and Th17 Cells

1:55 p.m. Francesco Annunziato (Member) University of Florence, Italy Stability of Human Th17 Cells in Chronic Inflammatory Disorders

2:20 p.m. Anne Puel (New Member) INSERM, Paris Descartes University, Imagine Institute, Paris, France IL-17 / Th17 Cell Defects and Infections

2:40 p.m. Pierre Miossec (Member) University Claude Bernard of Lyon, France Th17 and Mesenchymal Cell Interactions and Chronicity of Inflammation

3:05 p.m. Break

3:25–5 p.m. Session IV: Mesenchymal / Immune Cell Interactions Chairs: Carlo Chizzolini, Richard Pope

3:25 p.m. Christopher Buckley (Invited Speaker) University of Birmingham, UK Why Does Chronic Inflammation Persist: A Key Role for the Stroma?

3:50 p.m. Steffen Gay (Invited Speaker) University of Zurich, Switzerland Epigenetics in Rheumatic Autoimmune Diseases

4:15 p.m. Theresa Lu (New Member) Hospital for Special Surgery, New York, NY, USA Regulating the Lymph Node Stromal Compartment in Health and Disease

4:35 p.m. Roland Liblau (Invited Speaker) University of Toulouse, France T-Cell-Mediated Autoimmunity Targeting Neurons: Lessons from Animal Models

6 p.m. Poster tour and discussion

8 p.m. DinnerCentre des Pensières Keith Elkon, Pierre Miossec Introduction of the 2015 New Members

THURSDAY, APRIL 16, 2015

8 a.m.–10 a.m. Session V: Immunodeficiencies and Autoimmunity Chairs: Reinhold Schmidt, Frédéric Rieux-Laucat

8 a.m. Jean-Laurent Casanova (Member) The Rockefeller University and Howard Hughes Medical Institute, New York, USA Toward a Genetic Theory of Childhood Infectious Diseases

8:25 a.m. Frank Nestle (Invited Speaker) St John’s Institute of Dermatology, King’s College London, London, UK Immune Homeostasis and Pathology in Tissue: Rules of Engagement

8:50 a.m. Arturo Zychlinsky (Invited Speaker) Max Planck Institute for Infection Biology, Berlin, Germany Extracellular Chromatin in Infections and Autoimmunity

9:15 a.m. Lars Ronnblom (Member) Uppsala University, Sweden The Role of the Type I Interferon System in Autoimmunity

9:35 a.m. Carla Rothlin (New Member) Yale University, USA Negative Regulation of Type 2 Immunity

10 a.m. Break

10:25–11:45 a.m. Session VI: B Cells and Autoimmunity Chairs: Jean-Claude Weill, Marie Wahren-Herlenius

10:25 a.m. Eric Meffre (Member) Yale School of Medicine, USA Defective Early B Cell Tolerance Checkpoints in Autoimmune Diseases

10:50 a.m. Andreas Radbruch (Member) German Rheumatism Research Centre, Berlin, Germany The Resting and the Restless Immunological Memory

11:15 a.m. Ann Marshak-Rothstein (Member) University of Massachusetts Medical School, Worcester, USA Cytosolic Nucleic Acid Sensors in the Regulation of B Cell Autoimmunity

11:40 a.m. Edgar Meinl (New Member) University of Munich, Germany The BAFF-APRIL System in Autoimmunity, with Reference to Multiple Sclerosis

and Lupus

12 p.m.–12:20 p.m. Session VII: In-Vivo Manipulation and New Treatments Chairs: Lucienne Chatenoud, Dorian Haskard

12 p.m. Marie Wahren-Herlenius (New Member) Karolinska Institute, Stockholm, Sweden Vaccination Triggers Polyclonal B Cell Activation and Promotes Autoantibody

Production in Sjögren’s Syndrome

12:20 p.m. Richard Bucala (New Member) Yale University Approaching the Gene-Specific Therapy of Autoimmunity at the MIF Locus

12:40 p.m. Keith Elkon, President, the Henry Kunkel Society University of Washington, Seattle, WA, USA Final Meeting Announcements

12:40 p.m. Postdoctoral Fellow/Junior Faculty Lunch with HKS Investigators Registration required.

For details and updates, please look at the website of the Society: http://henrykunkelsociety.org/Upcoming-Meeting.aspx

Contact:Pr Pierre Miossec, University of Lyonmiossec@univ-lyon1.fr

Local organization:Pierre MiossecMarie MiossecFlavie Faes

A special thank you to our meeting sponsors