The Medical Foundation Where Science and Philanthropy Converge

2016 Program Awardees and Scientific Review Committees

The Medical Foundation

Welcome Since 1957, The Medical Foundation at HRiA has been a recognized leader in developing high-impact biomedical research grant programs that accelerate medical discoveries and advance public health.

The Medical Foundation is proud to:

• partner with private individuals, family foundations, and bank trusts to create and managecustomized grant programs,

• offer life sciences consulting services to determine the best way to impact the field,

• work with distinguished scientific experts to impartially review proposals,

• and efficiently manage 14 funding opportunities.

In 2016, on behalf of our clients, The Medical Foundation distributed over $21 million in new grants to 93 postdoctoral fellows, junior faculty, and independent research scientists worldwide.

This document recognizes each of the clients, committee members, and awardees who are helping to spur new findings in medicine and clinical care, advance scientific career development, and improve the health outcomes for countless numbers of people.

2016 Programs

• Dr. Ralph and Marian Falk Medical Research Trust

• Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research

• Charles H. Hood Foundation Child Health Research Awards Program

• Jeffress Trust Awards Program in Interdisciplinary Research

• Charles A. King Trust Postdoctoral Research Fellowship Program

• Lymphatic Education & Research Network (LE&RN) Postdoctoral Fellowship Program

• Deborah Munroe Noonan Memorial Research Fund

• Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Awards

• Smith Family Awards Program for Excellence in Biomedical Research

• Henry and Marilyn Taub Foundation Grants Program for MDS Research

• Edward N. and Della L. Thome Memorial Foundation Awards Program in Age-Related Macular

Degeneration Research

For the latest information, please visit: The Medical Foundation: hria.org/tmf/TheMedicalFoundation

2016 Awardees Dr. Ralph and Marian Falk Medical Research Trust Catalyst Awards

Amanda Garner, Ph.D. University of Michigan Leveraging the microRNA Interactome for Cancer Drug Discovery

Jeffrey Glenn, M.D., Ph.D. Stanford University Targeting RNA Secondary Structure--Towards a New Class of High Barrier to Resistance Antiviral Agents.

Zhiwei Hu, M.D., Ph.D. The Ohio State University College of Medicine and Public Health Targeting Tissue Factor as a Novel Oncotarget for Immunotherapy of Triple Negative Breast Cancer Using a Second Generation Icon

Joseph Leventhal, M.D., Ph.D. Northwestern University Clinical Transplant Tolerance Induction by the Use of Ex Vivo Expanded Antigen Specific Regulatory T Cells

Richard Lieber, Ph.D. Rehabilitation Institute of Chicago Breakthrough Technology to Measure Human Muscle Function

David Masopust, Ph.D. University of Minnesota Ablating Tumors with Resident Memory T Cells

Steven McMahon, Ph.D. Thomas Jefferson University Modulation of the Anti-tumor Immune Response by the Myc Oncoprotein, Implications for Cancer Therapy

Markus Müschen, M.D., Ph.D. Beckman Research Institute of City of Hope CD25 As Therapeutic Target in Refractory B Cell Malignancies

Tommi Raij, M.D., Ph.D. Rehabilitation Institute of Chicago Re-Wiring the Human Brain

Stephen Waggoner, Ph.D. Cincinnati Children's Hospital Medical Center Harnessing Natural Killer Cells to Treat Autoimmune Disease

2016 Awardees Dr. Ralph and Marian Falk Medical Research Trust Transformational Awards

Mark Feinberg, M.D.

Brigham and Women's Hospital MicroRNA-based Therapeutics for Diabetic Wound Healing

Michael Nishimura, Ph.D.

Loyola University of Chicago TCR Gene Modified T Autologous Cells for Treating RCC Patients

Stephen Strittmatter, M.D., Ph.D.

Yale School of Medicine Therapeutic Targets to Rescue Synapse Loss in Alzheimer's Disease

For more information, please visit: Falk Catalyst Awards: hria.org/tmf/FalkCAP Falk Transformational Awards: hria.org/tmf/FalkTAP

2016 Awardees

Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research

Coeli Lopes, Ph.D.

University of Rochester School of Medicine and Dentistry Effect of Statin Therapy in Combination with KCNH2 Targeting Drugs: Identifying Cardiac Arrhythmia Risk in Coronary Artery Disease Patients

Javier Lopez, M.D. University of California, Davis School of Medicine Matching Stem Cell-derived Myocytes to Individual Patients' Heart Tissues: Personalizing Future Regenerative Treatments for Ischemic Heart Disease

For more information, please visit: hria.org/tmf/Geneen

2016 Awardees Charles H. Hood Foundation Child Health Research Awards Program January Cycle Jenna Galloway, Ph.D. MGH Center for Regenerative Medicine The Role of a Novel Pathway in Vertebrate Tendon Development

Shangqin Guo, Ph.D. Yale School of Medicine Molecular Definition of Cancer Cell-of-Origin in B-ALL

Read Pukkila-Worley, M.D. University of Massachusetts Medical School Homeostatic Regulation of Innate Immune Activation in Intestinal Epithelial Cells

Vijay Rathinam, Ph.D. University of Connecticut Health Center Inflammatory Mechanisms in Enteric Bacterial Disease

July Cycle April Craft, Ph.D. Boston Children's Hospital Identifying Mechanisms of Cartilage Homeostasis and Degeneration Through the Use of Patient Specific iPSCs

George Dragoi, M.D., Ph.D. Yale School of Medicine Brain Mechanisms underlying Cognitive Development during Childhood

Benjamin Lee, M.D. University of Vermont College of Medicine The Effects of Increased Inoculum on Oral Rotavirus Vaccine Take and Immunogenicity

Farrah Mateen, M.D., Ph.D. Massachusetts General Hospital Remote Diagnosis of Pediatric Epilepsy through a Smartphone-based EEG

Annapurna Poduri, M.D. Boston Children's Hospital Zebrafish Models of PCDH19-related Pediatric Epilepsy

Dorothy Schafer, Ph.D. University of Massachusetts Medical School The Function of Immune cells and Sensory Experience on Brain Circuit Development

For more information, please visit: hria.org/tmf/Hood

2016 Awardees Charles H. Hood Foundation Major Grants Initiative to Advance Child Health

Trudy Morrison, Ph.D.

University of Massachusetts Medical School Protection of Neonates from Respiratory Syncytial Virus Infection

James Noonan, Ph.D.

Yale University Discovering Gene Regulatory Networks in Early Human Brain Development that Contribute

to Autism Spectrum Disorder

2016 Awardees Jeffress Trust Awards Program in Interdisciplinary Research Laura Barnes, Ph.D. University of Virginia A Novel Computational Framework for Prediction of Severe Sepsis and Response to Therapy Andreas Gahlmann, Ph.D. University of Virginia Harnessing the Power of Bacterial Populations Kristine Grayson, Ph.D. University of Richmond Using Genome-Wide Association Models to Determine the Genetic Architecture of an Invasive Forest Insect Kristian Hargadon, Ph.D. Hampden-Sydney College Bioinformatic Analysis of CD8+ T Cell Differentiation in Tumor-free Versus Tumor-involved Lymph Nodes Christine Helms, Ph.D. University of Richmond Properties of Aligned Electrospun Nanofibers Eric Johnson, Ph.D. Virginia Wesleyan College Enigmatic Proteins in Ancient Cell Types: Identifying a Role for Arabinogalactan Proteins in Moss Spermatogenesis Kyle Lampe, Ph.D. University of Virginia Simulation and Synthesis of Engineered Extracellular Matrix Proteins for Neural Tissue Engineering David Lattanzi, Ph.D. George Mason University Connecting 3D Imaging and Computational Mechanics for Next-generation Civil Infrastructure Assessment Sara Maxwell, Ph.D. Old Dominion University Seabird Collision Risk Models to Balance Ecological Protections and Access to Clean Energy Carolina Salvador Morales, D.Phil. George Mason University Using Computational Modeling for the Design and Optimization of Novel Cancer Theranostics Woon-Hong Yeo, Ph.D. Virginia Commonwealth University Ultrathin, Nanomembrane Electronics for Quantitative Monitoring of Sodium Intake

For more information, please visit: hria.org/tmf/Jeffress

2016 Awardees Charles A. King Trust Postdoctoral Fellowship Program Basic Science Kristopher Burkewitz, Ph.D. Harvard School of Public Health Targeting the ER-Mitochondrial Interface to Combat Age-Related Disease

Ashesh Dhawale, B.Sc., Ph.D.

Harvard University Role of the Basal Ganglia in the Learning and Execution of Motor Sequences

Jeffrey Farrell, Ph.D.

Harvard University Dissection of a Newly Discovered DNA Damage Response Pathway in Early Zebrafish Embryogenesis

Saiyu Hang, Ph.D.

University of Massachusetts Medical School Regulation of Th17/Treg Balance by Gut Bacterial Modification of Bile Acids

Jin-Mi Heo, Ph.D.

Harvard University Determine Pathophysiological Mechanisms How Mutations on OPTN and TBK1 Cause Glaucoma

Soyon Hong, Ph.D.

Boston Children's Hospital Early Role of Complement and Microglia in Mediating Synapse Loss in Alzheimer's Disease

Benjamin Kleinstiver, Ph.D.

MGH Cancer Center Improving the Efficiency of Precise CRISPR/Cas9 Mediated Genome-Editing

Marieke Kuijjer, Ph.D., M.Sc.

Dana-Farber Cancer Institute Modeling the Effects of Gene Regulation on Cancer Survival

Xing Liu, Ph.D.

Program in Cellular and Molecular Medicine at Boston Children's Hospital Mechanism of Global mRNA Decay During Apoptosis

Continued on the next page.

2016 Awardees

Gillian Matthews, Ph.D. National Institutes of Health Dissecting the Neural Circuitry of Loneliness

Upasna Sharma, Ph.D.

University of Massachusetts Medical School Epigenetic Inheritance of Paternal Environmental Conditions

Elenoe Smith, Ph.D.

Boston Children's Hospital Modeling and Disrupting Non-Coding Regulatory DNA Sequences to Inform Sickle Cell Disease Therapy

Pei-Chi Wei, Ph.D.

Boston Children's Hospital Roles of Recurrent DNA Break Cluster Genes in Neural Development and Disease

Moran Yassour, Ph.D.

Broad Institute of MIT and Harvard Decoding the Origin and Development of the Newborn Gut Microbiome

Charles A. King Trust Postdoctoral Fellowship Program Clinical/Health Services Franziska Plessow, Dr. rer. nat.

Massachusetts General Hospital Cognitive Control as a Biomarker and Target for Novel Interventions in Low-Weight Eating Disorders

Donald Robinaugh, Ph.D.

Massachusetts General Hospital Examining Symptom Decoupling and Propagating Causal Influence as Intra-individual Mechanisms of Change in Psychotherapy

For more information, please visit: hria.org/tmf/King

2016 Awardees

Lymphatic Education & Research Network (LE&RN) Postdoctoral Fellowship Awards Program Esak Lee, Ph.D.

Wyss Institute at Harvard University A Biomimetic on-Chip Model to Reconstitute Lymphedema

Antoine Louveau, Ph.D.

University of Virginia Regulation of Brain Homeostasis by the Meningeal Lymphatic Vasculature

For more information, please visit: hria.org/tmf/LERN

2016 Awardees

Deborah Munroe Noonan Memorial Research Fund Linda Bandini, Ph.D. Eunice Kennedy Shriver Center, University of Massachusetts Medical School The Impact of Selective Eating on the Lives of Transition-age Youth with Autism Spectrum Disorder

Scott Greenwald, Ph.D. Massachusetts Eye and Ear Infirmary Gene Augmentation Therapy for Preserving Vision in NMNAT1-associated Leber Congenital Amaurosis

Danielle Levac, P.T., Ph.D. Northeastern University Usability Evaluation of the FITBoard (Fun Interactive Therapy Board): A Motivating, Movement-Based Rehabilitation Tool for Children with Disabilities

Yudy Muneton, M.A., M.S.W.

Boston Children's Hospital Efficacy And Feasibility of Tele-Psychotherapy Intervention to Support Parents Caring for Technology-dependent Children At Home

Christina Sakai, M.D.

Tufts Medical Center Pathways to Autism Diagnosis and Services in the Chinese-Immigrant Community Population

Sara Toomey, M.D.

Harvard Pilgrim Health Care Steps to Improving Parent Engagement and Shared Decision Making for Parents of Children with Disabilities and Medical Complexity

For more information, please visit: hria.org/tmf/Noonan

2016 Awardees Patterson Trust Fellowship Program in Clinical Research Damion Grasso, Ph.D. University of Connecticut Health Center Maternal Exposure to Violence, Pregnancy and Birth Outcomes, and Stress-Related Epigenetic Risk

Carolyn Greene, Ph.D.

University of Connecticut Health Center The Role of Parental Emotion Regulation in Evidence-Based Treatment for Children with PTSD

Caitlin Hansen, M.D.

Yale School of Medicine Development of a School-Based Health Center HPV Vaccination Intervention

Kelly Hawley, Ph.D.

University of Connecticut Health Center Elucidating Innate and Adaptive Immune Interplay in Human Syphilis

Tae-Kon Kim, M.D., Ph.D. (supported by the Seery Foundation)

Yale University Overcoming Immune Evasion in Acute Myeloid Leukemia (AML) with DNA Methyltransferase (DNMT) Inhibition and PD-1H Blockade

Kevin Manning, Ph.D. University of Connecticut Health Center Physical Mobility and Driving in Subjective and Mild Cognitive Impairment

Carlos Oliveira, M.D., Ph.D. Candidate Yale University Clinical Effectiveness of the Human Papillomavirus Vaccine

Georgios Pantouris, B.Sc., Ph.D. Yale University Targeting Hematological Cancers Using a Small Molecule Inhibitor with a Novel Mechanism of Action.

Lisa Parikh, M.D. Yale University Investigating the Central and Peripheral Mechanisms by which Glucocorticoids Affect Hunger

Continued on the next page.

2016 Awardees

Abhinav Seth, M.D., Ph.D. Yale University Regulation of Follicular Helper T Cell Development and Function

Reshef Tal, M.D., Ph.D.

Yale School of Medicine The Role of Bone Marrow and Endothelial Progenitor Cells in Implantation, Placentation and Early Pregnancy Development

Gwendolyn Thomas, Ph.D.

Syracuse University (previously, Yale School of Public Health) An Enhanced Behavioral Intervention to Increase Daily Exercise Adherence in Breast Cancer Survivors

Andrey Zinchuk, M.D.

Yale University Identification and Validation of Clinically Relevant Obstructive Sleep Apnea Phenotypes

For more information, please visit: hria.org/tmf/Patterson

2016 Awardees Smith Family Awards Program for Excellence in Biomedical Research Jerry Chen, Ph.D.

Boston University Circuit Mechanisms for Long-Range Communication in the Neocortex

Aleksandar Kostic, Ph.D.

Joslin Diabetes Center Immunological Investigation of Human Type 1 Diabetes-Associated Microbiomes in the Gnotobiotic Autoimmune Diabetic Mouse

Philip Kranzusch, Ph.D. Dana-Farber Cancer Institute Mechanism of Activation of a New Human RNA Second Messenger Signaling Enzyme

Gene-Wei Li, Ph.D. Massachusetts Institute of Technology Breaking the Robustness of Bacterial Translation

Maofu Liao, Ph.D. Harvard Medical School Cryo-EM Studies of Multidrug Resistance Conferred by Human ABC Transporters

Noah Palm, Ph.D. Yale University A Universal Genetic Toolkit to Illuminate Host-Microbiota Interactions

Silvia Rouskin, Ph.D. Whitehead Institute for Biomedical Research Identifying the factors required for mRNA localization during metazoan development

Mansi Srivastava, Ph.D. Harvard University Cellular Dynamics and Regulation of Pluripotent Stem Cells in vivo

For more information, please visit: hria.org/tmf/Smith

2016 Awardees The Henry and Marilyn Taub Foundation Grants Program for MDS Research Omar Abdel-Wahab, M.D.

Memorial Sloan-Kettering Cancer Center Understanding and Manipulating Pathologic Splicing Preferences and Nonsense-mediated mRNA Decay (NMD) in Spliceosomal-mutant MDS

Gang Huang, Ph.D.

Cincinnati Children's Hospital Medical Center The Role of HIF-1α As a Central Pathobiologic Mediator of Myelodysplastic Syndromes

Daniel Link, M.D.

Washington University in St. Louis Stromal CXCL12 in MDS Pathogenesis

Ulrich Steidl, M.D., Ph.D.

Albert Einstein College of Medicine Mechanisms of MDS Initiation at the Stem Cell Level

For more information, please visit: hria.org/tmf/Taub

2016 Awardees

The Edward N. & Della L. Thome Memorial Foundation Awards Program in Age-Related Macular Degeneration Research

Rajendra Apte, M.D., Ph.D.

Washington University School of Medicine in St. Louis Disrupted Cholesterol Homeostasis in AMD Pathogenesis

Milam Brantley, M.D., Ph.D.

Vanderbilt University Medical Center Understanding the Mechanism of Bile Acids' Influence on AMD Pathophysiology

Lihua Marmorstein, Ph.D.

Mayo Clinic Developing Therapeutic Strategies to Treat Dry AMD using Malattia Leventinese/Doyne Honey Comb Retinal Dystrophy (ML/DHRD) as a Model

Jose Sahel, M.D.

University of Pittsburgh High resolution structural phenotyping of intermediate and advanced age-related-macular-degeneration

Stephen Tsang, M.D., Ph.D.

Columbia University Medical Center Genome Engineering of AMD Risk Alleles in Patient-Specific Stem Cells

Marco Zarbin, M.D., Ph.D.

Rutgers University New Jersey Medical School Improving Cell-based Therapy for Age-Related Macular Degeneration

For more information, please visit: hria.org/tmf/ThomeAMD

2016 Scientific Review Committees

Dr. Ralph and Marian Falk Medical Research Trust Awards Programs Catalyst and Transformational Bo Saxberg, M.D., Ph.D. (Chair)

William Barson, M.D. Eric Beyer, M.D., Ph.D.

Bruce Bloom, D.D.S., J.D.

Ernesto R. Bongarzone, Ph.D.

Benjamin Gaston, M.D. Mehrnoosh Ghiam, Ph.D.

Elizabeth Horn, Ph.D.

Anthony Koleske, Ph.D.

Andrey Rzhetsky, Ph.D. Edward Spack, Ph.D.

Charles H. Hood Foundation Child Health Research Awards Program Bobby J. Cherayil, M.D. (Chair)

Elizabeth D. Barnett, M.D.

Clifford W. Bogue, M.D.

Howard Cabral, Ph.D., MPH Elizabeth Engle, M.D.

Beth A. McCormick, Ph.D.

Jill L. Maron, M.D., MPH

Camilia Martin, M.D., MS Peter J. Park, Ph.D.

Mustafa Sahin, M.D., Ph.D.

Susanne Tanski, M.D., MPH

Deborah Munroe Noonan Memorial Research Fund Susan L. Parish, Ph.D. (Chair)

Deborah Allen, Sc.D. Susan Bruce, Ph.D.

Beth Dworetzky, M.S.

JoAnna Leyenaar, M.D., M.P.H. John Maypole, M.D.

Robert Volpe, Ph.D.

2016 Scientific Review Committees Thomas F. and Kate Miller Jeffress Memorial Trust Awards Program Donald Brown, Ph.D. (Chair)

David Chan, Ph.D.

James Gentle, Ph.D. Ina Hoeschele, Ph.D.

Debra Hydorn, Ph.D.

Yiannis Papelis, Ph.D. Stacie Ringleb, Ph.D.

Gregory Smith, Ph.D.

Diego Troya, Ph.D.

Robert E. Leet and Clara Guthrie Patterson Trust Awards Program in Clinical Research Lori Bastian, M.D., MPH (Chair)

Mark D. Litt, Ph.D.

Kristin Mattocks, Ph.D.

Heber Nielsen, M.D. Elijah Paintsil, M.D.

Junichi Sadoshima, M.D., Ph.D.

David Steffens, M.D.

Charles A. King Trust Postdoctoral Fellowship Program Clinical and Health Services Research Kenneth J. Mukamal, M.D., M.P.H. (Chair)

Matthew P. Frosch, M.D., Ph.D.

Robert C. Fuhlbrigge, M.D., Ph.D. P. Ellen Grant, M.D.

Shelly F. Greenfield, M.D.

John Griffith, Ph.D.

Marek Kubicki, M.D. Neal Silverman, Ph.D.

Christine Wanke, M.D.

2016 Scientific Review Committees Charles A. King Trust Postdoctoral Fellowship Program Basic Science Catherine Dulac, Ph.D. (Chair)

Ingolf Bach, Ph.D. Stephen Blacklow, M.D., Ph.D.

David Center, M.D.

Erin Cram, Ph.D. Job Dekker, Ph.D.

Michael Eck, M.D., Ph.D.

Marc Freeman, Ph.D.

Dale Greiner, Ph.D. Michael Hemann, Ph.D.

Takao Hensch, Ph.D.

Paul Huang, M.D., Ph.D.

Robin Ingalls, M.D. Jonathan Kagan, Ph.D.

Michelle Kelliher, Ph.D.

Gabriel Kreiman, Ph.D.

Mitzi Kuroda, Ph.D. Andrew Lane, M.D., Ph.D.

Nelson C. Lau, Ph.D.

Sacha Nelson, M.D., Ph.D.

William Pu, M.D. Avital Rodal, Ph.D.

Ralph Scully, Ph.D.

Lois Smith, M.D., Ph.D.

Kevin Struhl, Ph.D. William Theurkauf, Ph.D.

Amy K. Walker, Ph.D.

Graham C. Walker, Ph.D.

David Waxman, Ph.D. Kristin White, Ph.D.

Matthew Wilson, Ph.D.

Amy S. Yee, Ph.D.

2016 Scientific Review Committees Richard and Susan Smith Family Awards Program for Excellence in Biomedical Research Gary Ruvkun, Ph.D. (Chair)

Iain Cheeseman, Ph.D. Ralph Isberg, Ph.D.

Venkatesh Murthy, Ph.D.

Suzanne Paradis, Ph.D.

Hidde Ploegh, Ph.D. Kornelia Polyak, M.D., Ph.D.

Joshua R. Sanes, PhD

Susan Swain, Ph.D.

Amy Wagers, Ph.D. Muhammad Zaman, Ph.D.

Edward N. & Della L. Thome Memorial Foundation Awards Program in Age-related Macular Degeneration Emily Y. Chew, M.D. (Chair)

Kapil Bharti, Ph.D.

Catherine Bowes Rickman, Ph.D.

Constance Cepko, Ph.D. Margaret DeAngelis, Ph.D.

Cynthia L. Grosskreutz, M.D., Ph.D.

James T. Handa, M.D.

Robert F. Mullins, Ph.D. Erich C. Strauss, M.D.

David J. Wilson, M.D.