223.19 endocytosis exocytosis2015
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Cell Biology
Lecture 223.20: Endocytosis and Exocytosis
Endocytosis
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Endocytosis-green arrows
Two Types (based on size)
pinocytosis (cellular drinking) < 150 nm; all cell phagocytosis (cellular eating) > 250 nm; phagocytic cells
receptor mediated
Pathways to Lysosomes
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Phagocytosis
Phagocytosis
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Pathways to Lysosomes
Endocytosis
*
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Endocytosis: Receptor-mediated
Endocytosis: Receptor-mediated
•
Selective process
• Mediated by clathrin
and transmembrane
receptor on cell surface
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Endocytosis - sorting in the endosome
Examples
Recycling - LDL receptor
Degradation - EGF receptor
Transcytosis - antibodies
Endocytosis -Sorting
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Endocytosis - sorting in the endosome
Examples
Recycling - LDL receptor
Degradation - EGF receptor
Transcytosis - antibodies
Sorting in Trans-Golgi Network
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Signal-mediated delivery to lysosomes
Lysosomal proteins are modified further in the Golgi
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Sorting in the Golgi- Lysosome Delivery
Sorting - Lysosome Delivery
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Exocytosis - Regulated Secretion
Exocytosis - Constitutive Secretion
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Exocytosis - Constitutive Secretion
Exocytosis - Regulated vs. Constitutive Secretion
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