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1

H2

H2 1776 249

78% N2 N2

2007

2014 80 23 -1

Pharmacology & Therapeutics 2014 Molecular hydrogen as

a preventive and therapeutic medical gas:initiation, development and potential of hydrogen

medicine.

23 -2 23 -3

23 -1

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2

23 -2 H2

23 -3 H2

/

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3

-

NK-Tcell

23 -4 23 -5 23 -6 23 -7

CO 2 C H2O N2

CHO CHON

CH CHO

23 -4 23 -5

23 -7 DNA 23 -6

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4

23 -8

23 -9 C H O 23 -10 N

H H+ ADP ATP H+

CHON O C O2

CO 2 CO 2 350~400ppm

CO 2 40,000~53,000ppm

23 -8

23 -9

23 -10

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5

H TOYOTA

3000 oC

H

H2 ADP

ATP H2 OH ●

O 2 O 2 H H O 2

O 2

O2 H2 O 2

O 2 H2 H2O

1.

Krebs cycle TCA cycle citric acid cycle 23 -18 ATP

Endogenesis water

23 -18 Q10

23 -18 H+ ATP

P ADP ATP 23 -18

O H

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23 -11 Krebs cycle

23 -12

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· · Hans Adolf Krebs

· · Hans Adolf Krebs 1900 8 25

1981 11 22

Krebs

cycle · · 1953

1918 1923

1925

· · 1930

1933 · 1945

1954

1958 1979 1981

http://ppt.cc/nuUY

2.

H O C H O

H O H2O O 2

H H H

17 H2

H2 H2

23 -13 Hans Adol f Krebs

http://ppt.cc/nuUYhttp://ppt.cc/nuUY

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8

H2O

23-14

Active transport

Endogenesis water H2 O 2

ATP

ATP 1953

Hans Adolf Krebs Krebs Cycle ATP H2O

YouTube Cellular Respiration Glycolysis Krebs cycle Electron Transport 3D

Animation Kreb cycle

1. 13 L

2. 17 /

23 -14

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9

H2 O 2

1. H 2O 23-6

outer membrane inner membrane

mitochondrial matric cytochrome oxidase ATP ATP Synthase

23-15

2. H NAD+ NADH 23-18

3. NADH NADH NADH Dehydrogenase ubiquinone Q10

Cytochrome b-c 1 Cytochrome c Cytochrome oxidase

4. FAD H2 Q10 Cytochrome oxidase 23-18

5. Cytochrome oxidase

O2 H2O Cytochrome oxidase

Endogenesis 23-18

6. NADH Dehydrogenase NADH NAD+ H Q10 H+

intermembrane space H+

H+

7. Cytochrome oxidase H+

H+ H+

Hydrogen Ion Gradient

8. H+ ATP ATP Synthase

ADP ADP ATP 23-18

9. ADP Adenosine Diphosphate ATP Adenosine Triphosphate

D 2 Tr 3 Phosphate P Adenosine ADP ATP

ADP ATP

ADP Adenosine-P+P

ATP Adenosine-P+P+P

P ATP P ADP

10. ATP ADP P P H+

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10

ATP ATP Synthase H+

11. ATP ATP P P

ADP ADP

ATP→ADP→ATP

ATP SynthaseATP

23 -15

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

ATP

23 -16

H

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

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11

100% H2O H

H2O OH ● 23-19 OH ●

H2 H2 NADH Q10

OH ● OH ● 23-20 H2 OH ● 2OH ●+

H2→2H 2O OH ● H2 DNA

H2

β 3D EEG

H2

4 H 2 H+ 2 OH ●

23 -17

Cytochrome Oxidase

↓

ATP Synth ase

ADP ↓

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

23 -18

ADP

ATP ADP

2 H2O

→

Cytochrome Oxidase

↓

ATP Sy nt hase

(ADP ) ↓

NADH NADH H Q10

-

Q1

↓

YouTube - Cellular Respiration: Glycolysis, Krebs cycle, Electron Transport [3D Animation]

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OH ● OH ●

H2+O 2 HRV

H2 OH ●

23 -21

H2 OH●

H2

23 -21

23 -19 OH ● 23 -20 H2O

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13

H2+O 2 H2O

H2+O 2

H2O H2O H2 O 2 H2+O 2

cytochrome oxidase H2 O 2

H2 ADP

ATP H2+O 2 3D EEG

O 2

50 XX H2+O 2 EEG

23 -22 23 -23

H2+O2

23 -22 H2+O 2 EEG 23 -23 H2+O 2 EEG

H2+O 2

23 -24 H2+O 2 23 -25 H2+O 2

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14

α β θ δ α β θ δ

1199 1547 23 -28

1. H2O H2O H2 O 2

2H 2O→2 H2+O 2

H2+O 2

23 -26 H2+O 2 23 -27 H2+O2

23 -28 H2+O2

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15

2. H2 O 2

H2 O 2 H2O

H2O H2

3. H2 H2 ATP

cytochrome oxidase ADP ATP 23 -18

2H 2O→2 H2+O 2

2H2+O 2→2H 2O H+ ADP ATP H2O

H2 H2O

H2

H2 H2+O 2

4. H2 O 2

ATP

5. ATP ADP ADP

ATP ATP Synthase H+ YouTube -Cellular

Respiration Glycolysis Chain Krebs cycle Electron Transport 3D Animation

6. OH ● H2 OH ●

H2 H2O 2 OH ●+ H 2→2H 2O

H2 H2

7. H2 H2 H+ ADP ATP

H2

8. H2 OH ● H2

ADP

H2

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16

9. 1953 Hans Adolf Krebs Krebs cycle

ATP H2O

10. Krebs ATP Electron

transfer Endogenesis water

Krebs Cycle

11. H2 OH ●

ATP H2

H2

H2 H2 H2

H2+O 2

1. H

H2

H2 10 500 O 2 21%

2. 17 H2

17 H2

H2

H2 H2+O 2 H2 H2+O2

3. H2

H2 O 2 H2 78% N2

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17

N2 78% H2

H2 1 1atm=760mmHg

H H2 O 2 16

H2 H2+O 2 O 2

33% H2 66% O2 20% N2 78% N2 H2

H2 H2

H2+O 2

O 2 H2

1. O 2 H2

2H2+O 2→2H 2O

OH ●

H2 2OH ●+H2→2H 2O

23 -29

O 2 ATP

OH ● H2

OH ● 2OH ●˙+H2→2H 2O

OH ● H2 OH ●

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18

/ / / / /

O 2 +O 2 ATP + OH ●

H2 2OH ● + H2 2H2O

23-29 O2 H2

2. H2+O 2

O 2 H2

2OH ● 2H 2O 2OH ●+H2→2H 2O

kidney

OH ●

H2+O 2

O 2

OH ● H2

OH ●

3. H2+O 2

H2 H2

coherene → synchronize → entrainment

→ harmony → homeostasis → efficiency → intuition

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19

OH ●

4. H2

H2

14.3 Hz

20.8 Hz 27.3 Hz 33.8 Hz 39.8 Hz

50% H2+O 2

5. H2+O 2 -

a.

SpO 2 99%

H2 H2

c.c.

H2+O2 5

10 -30

H2 side effect

adverse effect

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H2+O 2

b.

H2+O2

H2

adverse effect

c.

H2+O 2

d.

H2+O 2 e.

H2+O 2

adverse effect

1. H2O H2O

2. H2+O 2 H2O 100% H2

O 2 H2

3. H2+O 2 H2

H2+O 2

H2

H2+O 2

passive transport

H2O

H2+O 2

1.

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21

2.

H2+O 2

1.

H2+O 2

H2+O 2

2.

3D

H2+O 2 β HRV

H2+O 2

β H2

3.

H2 H2+O 2 EEG HRV

H2+O 2

1 5 5 5 10 15

H2+O 2

4.

10 80 H2+O 2 HRV EEG

60 EEG HRV

H2

8/15/2019 23 H2

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H2

2014 3 19

H2+O 2

3D EEG HRV

H2

H2

1.

You Tube

Cellular Respiration Electron Transport

Cellular Respiration Glycolysis Chain Krebs cycle Electron Transport 3D Animation

How Cells obtain energy

ATP-energy of the cell

Cellular Respiration-Energy in a cell

What ATP is and How it Works- BioVid Episode 3

Powering the Mitochondria BioVid Episode-3

H2

2.

a.

b. 800 H2bestdrug.blogspot.com

c. http://hydrogenconference/blogspot.tw/