12 01neur

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The final exam: Same format as mid-term exam, just longer.

3 hours

December 16th, 2:00pm in Alumni Hall (rows 21-30)

This is an ocial exam, which means that it will be administered by Carletons Scheduling & Exam Services. All special requests, sudden illnesses, deferrals, etc., will be

handled through official channels not through me. Rules about deferrals are much stricter on official exams they are

handled through the registrars office and written in January. Make sure you read, understand, and follow all of the rules for

writing formal exams: they will call you on them.

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The final exam:

Mid6term%content%

Final%content%

Please remember that while there were technically more lectures worth of material on the midterm, there are more articles, and more unique topics for the final. On the whole, there is more testable content in the second half of the course.

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The final exam: The exam will consist of:

25 multiple choice @ 1 point each total: 25pts ~24%

20 definitions @ 2 points each total: 40pts ~38%

12 short answer questions with between 1-5 points each total: 40pts ~38%

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Example definitions Definitions are marked out of 2, and should include two pieces of information on the

definiendum (the word being defined).

Example:

-Drugs are bad!4) Drug

-Substances that affect the function of the brain and body !

4) Drug

-Substances that exert a relatively large effect on physiology.!-Can be naturally occurring or synthetic!

4) Drug

0 - bad

1 - ok

2 - best

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Example short answers Short answers are worth varying amounts (between 1-5 points). At minimum, your answer

should include as many pieces of information as there are points in the question.

Example: Using information from Nestlers article and lectures, explain what the science of epigenetics tells us about drug addiction? (4)

-Drugs are bad! 0 - bad Chronic exposure to addictive drugs such as cocaine leads to changes in histone acetylation and methylation. These changes last a long time after the drug is out of the system, and may explain why addiction is a long-lasting disorder!

2 - good

Exposure to cocaine activates nearly 100 genes in the brain. Chronic exposure to cocaine leads to increases in histone acetylation and decreases in histone methylation of genes in reward areas of the brain. This has the net effect of loosening chromatin structure, leading to long-term increases in gene expression that may explain why addiction lasts so long. This happens because cocaine affects the activity of enzymes nicknamed writers and erasers.!

4 - best

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How to get help1. Contact your TA, ask questions via email or arrange an

appointment.

2. Contact me

3. Pre-exam online oce hours: December 15th, 7-9pm Use Big Blue Button on this classs cuLearn page (available

during specified hours I will be online the whole time, as will your TAs

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