3-o-b1-1 oral sessions analyses of forming hetero ...intranasal oxytocin administration improves...

3-O-B1-1

Analyses of Forming Hetero-oligomers and Regulating Signal transductionsof G-Protein Coupled Receptors (GPCRs) Expressed in the Central NervousSystem.

Hakushun Sakairi1, Yuji Kamikubo1, Hikaru Kono1, Kei Yamamoto1, Toshihide Tabata2,Takashi Sakurai1

1Dept. Pharmacol., Juntendo Univ. Sch. of med., 2Fac Eng, Univ Toyama

Oral Sessions

Copyright © The Japanese Pharmacological Society

3-O-B1-2

Projection-identified large-scale recording reveals pathway-specificinformation outflow from the subiculum

Takuma Kitanishi1,2, Ryoko Umaba3, Kenji Mizuseki1

1Dept Physiol, Osaka City Univ Grad Sch Med, 2PRESTO, JST, 3Dept Neurosurg, Osaka City Univ Grad Sch Med

Oral Sessions


3-O-B1-3

Synchronous activity of event and place representations inhippocampal CA1

Kotaro Mizuta1,2, Masaaki Sato2,3,4,5, Yukiko Sekine2,3, Masako Kawano2, Tanvir Islam2,3, Yao-Long Li1, Takashi Takekawa2,6, Masamichi Ohkura5, Junichi Nakai5,7, Yasunori Hayashi1,2,5

1Dept. Pharmacol. Kyoto Univ., 2BSI RIKEN, 3CBS RIKEN, 4Neuropharmacol. Hokkaido Univ, 5Brain Body Sys. Sci.Inst. Saitama Univ., 6Fac. Inf. Kogakuin Univ., 7Oral Physiol. Grad. Sch. of Dent. Tohoku Univ.

Oral Sessions


3-O-B1-4

Bidirectional regulation by the endocannabinoid in retrieval of fear memoryusing the fear conditioning task in mice

Yoko Nawata1, Asami Ueno1, Tsuyoshi Nishioku1, Taku Yamaguchi2

1Dept. Pharmacol., Fac Pharmaceut. Sci., Nagasaki Intl. Univ., 2Dept. Pharmacother. and Neuropsychopharmacol.,Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

Oral Sessions


3-O-B2-1

Electroconvulsive seizure before conditioning inhibits fear memoryformation

Rentaro Kurata, Yuichiro Hongo, Chiaki Takeuchi, Miho Ishikawa, Toshinori Sawano,Kazuyoshi Kosaka, Jin Nakatani, Hidekazu Tanaka

Lab. Pharmacol., Grad. Sch. Life Sci., Ritsumeikan Univ.

Oral Sessions


3-O-B2-2

Development of a five-armed bandit task for assessing behavioral flexibility

Ohta Hiroyuki1, Masashi Arake2, Kuniaki Satori3, Yu Takarada3, Tatsuji Takahashi3,Yasushi Satoh3, Yuji Morimoto2, Toshiaki Ishizuka1

1Dept. Med., NDMC, 2Dept. Phisol., NDMC, 3Tokyo Denki Univ.

Oral Sessions


3-O-B2-3

Ninjin’yoeito ameliorates behavioral declines in aged C57BL/6J mice

Yosuke Matsubara, Ryota Imai, Shinji Miyazaki, Eisuke Haneda, Yuko Miyama, Yuji Omiya,Yoshiki Ikeda

Tsumura Kampo Research Laboratories, Tsumura & Co.

Oral Sessions


3-O-B2-4

Closed-loop stimulation of the medial septum terminates epileptic seizures

Yuichi Takeuchi1

1Dept. Physiol., Grad. Sch. Med. Osaka City Univ., 2Dept. Physiol., Fac. Med., Univ. Szeged

Oral Sessions


3-O-B2-5

MEA measurement in brain organoid

Remi Yokoi1,2, Yuto Ishibashi1, Naoki Matsuda1, Nami Nagafuku1, Ikuro Suzuki1

1Tohoku Institute of Technology,2JSPS

Oral Sessions


3-O-C1-1

Hearing impairment associated with dysmyelination of the peripheralcochlear nerve in muscular dystrophy caused by aberrant α-dystroglycanglycosylation

Shigefumi Morioka1,2,3, Hirofumi Sakaguchi3, Hiroaki Mohri2, Mariko Ikeda4, Motoi Kanagawa5,Naoaki Saito2, Takehiko Ueyama2

1Dept. of Otolaryngology, Kyoto City Hosp., 2Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ.,3Dept. of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural Univ. of Med.,4Dept. of Clinical Genetics,Fujita Health Univ. Hosp., 5Dept. of Mol. Cardiovascular Biol. and Pharmacol. Ehime Univ.

Oral Sessions


3-O-C1-2

An attempt to establish an assay system for protective agents againstglutamate-induced neurotoxicity using QNR/D cells, a cell line derived fromquail embryotic neruroretinas

Kenji Sakamoto, Kazuya Katsumata, Asami Mori, Takashi Uezono

Lab. Med. Pharmacol., Fac. Pharma-Sci., Teikyo Univ.

Oral Sessions


3-O-C1-3

Early reactive gliosis at optic nerve head in normal-tension glaucoma

Youichi Shinozaki1,2, Kazuhiko Namekata3, Kenji Kashiwagi4, Nobuhiko Ohno5,6, Eiji Shigetomi1,2,Takayuki Harada3, Schuichi Koizumi1,2

1Dept. Neuropharm., Grad. Sch. Med., Univ. Yamanashi,2YiBIC, Univ Yamanashi,3Vis. Res. Project., Tokyo Metr.Inst. Med. Sci., 4Dept. Ophthalmol, Interdiscip. Grad. Sch. Med. Univ. Yamanashi,5Dev. Ultrastruct. Res., Natl. Inst.Physiol. Sci., 6Div. Anatomy, Jichi Med. Univ.

Oral Sessions


3-O-C1-4

P2Y1 receptor is a novel target for anti-glaucoma treatment

Hamada Kentaro1, Yoichi Shinozaki1,2, Namekata Kazuhiko3, Nobuhiko Ohno4,5,Takahiko Segawa6, Takayuki Harada3, Kenji Kashiwagi7, Shuichi Koizumi1,2

1Dept. Neuropharmacol., Interdiscip. Grad. Sch. Med. Univ. Yamanashi,2Cent. Life Sci. Res., Univ. Yamanashi.,3Vis. Res. Project, Tokyo Metr. Inst. Med. Sci.,,4Dev. Ultrastruct. Res., Natl. Inst. Physiol. Sci.,, 5Div.Anatomy,Jichi 6Med.Univ.,, 6The Center for life Science Research, Univ.Yamanashi,7Dept.Opthalmol.,Interdiscip.Grad.Sch.Med.Univ.Yamanashi

Oral Sessions


3-O-C2-1

Chemogenetic activation of astrocytes in the ventral hippocampus

Eiji Shigetomi, Schuichi Koizumi

Dept. Neuropharmacol. Interdiscipl. Grad. Sch. Med., Univ. Yamanashi

Oral Sessions


3-O-C2-2

Neuronal excitation mechanism through activation of astrocytic P2Y1receptor.

Suzuki Hideaki1, Eiji Shigetomi1, Yukiho Hirayama1, Fumikazu Sano1, Kenji Tanaka2,Haruhiko Bito3, Schuichi Koizumi1

1Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi,2Dept Neuropsych, Keio Univ Sch Med, 3DeptNeurochem, Grad Sch Med, Univ Tokyo

Oral Sessions


3-O-C2-3

Astrocytic density tunes presynaptically silent synapses

Shutaro Katsurabayashi, Kohei Oyabu, Kotomi Takeda, Kaori Kubota, Takuya Watanabe,Katsunori Iwasaki

Dept. of Neuropharmacol., Fac of Pharmaceut. Sci., Fukuoka Univ.

Oral Sessions


3-O-C2-4

Differential adrenergic regulation of process formation in cortical and spinalcord astrocytes

Taisuke Kitano, Ryota Eguchi, Ken-ichi Otsuguro

Lab. Pharmacol. Fac. Vet. Med. Hokkaido Univ.

Oral Sessions


3-O-C2-5

Hydrogen sulfide increases intracellular Ca2+ concentration by inhibition ofmitochondrial respiration in cultured rat spinal cord astrocytes.

Nii Takeshi, Ryota Eguchi, Ken-ichi Otsuguro

Lab. Pharmacol. Fac. Vet. Med. Hokkaido Univ.

Oral Sessions


3-O-D1-1

The physiological alteration of histidine-rich glycoprotein on the miceperinatal period.

Kiyoshi Teshigawara1, Keyue Liu1, Dengli Wang1, Hidenori Wake1, Shuji Mori2, Hideo Takahashi3,Masahiro Nishibori1

1Dept. of Pharm., Okayama Univ. Grad. Sch. of Med., Dent. and Pharm. Sci., 2Sch. of Pharm., Shujitsu Univ., 3Dept.of Pharm., Kinki Univ., Fac. of Med.

Oral Sessions


3-O-D1-2

Molecular mechanisms underlying the agonistic effect ofnondihydropyridine FPL64176 on Cav1.2 Ca2+ channels

Mitsuhiko Yamada, Simmon Gomi, Takuro Numaga-Tomita

Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med.

Oral Sessions


3-O-D1-3

Expression analysis of Ca2+-sensing receptor and TRPC6 channel inmonocrotaline-induced pulmonary hypertensive rats

Kawade Akiko1, Aya Yamamura2, Yoshiaki Suzuki1, Hisao Yamamura1

1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Physiol ., Aichi Med Univ.

Oral Sessions


3-O-D1-4

Role of Ca2+-activated K+ channel KCa1.1 in human osteosarcoma spheroids

Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito

Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Oral Sessions


3-O-D2-1

A mechanism underlying hERG current increase by a blocker

Kazuharu Furutani1,3, Steffen Docken2, Igor Vorobyov1, Colleen Clancy1, Timothy Lewis2,Jon Sack1

1Department of Physiology and Membrane Biology, University of California Davis, 2Department of Mathematics,University of California Davis, 3Department of Pharmacology, Faculty of Pharmaceutical Sciences, TokushimaBunri University

Oral Sessions


3-O-D2-2

Involvement of Kir2.1 channels on the migration of mouse bone marrow-derived macrophages

Katayama Taiju, Kazuki Maeda, Toshio Yamamura, Yoshiaki Suzuki

Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Oral Sessions


3-O-D2-3

Role of inward rectifier K+ channel Kir2.1 in mouse osteoblast differentiation

Hiroaki Kito, Kyoko Endo, Junko Kajikuri, Susumu Ohya

Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Oral Sessions


3-O-D2-4

Functional expression of TREK-1 channels in human hepatic stellate cells

Akari Deguchi, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura


Oral Sessions


3-O-D2-5

Inhibitory mechanism of melatonin on voltage-dependent Kv4.2 channels

Hiroki Mishima, Yoshiaki Suzuki, Hisao Yamamura


Oral Sessions


3-O-E1-1

Serotonin neuron-specific transcriptome profiling in chronic SSRI-treatedmice and chronic social defeat stress model mice

Chihiro Andoh1, Masako Hagiwara1, Naoya Nishitani2, Kazuki Nagayasu1, Hisashi Shirakawa1,Shuji Kaneko1

1Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Lab. Mol. Pharmacol., Inst. Med.,Pharmaceut., Health Sci., Kanazawa Univ.

Oral Sessions


3-O-E1-2

Modulation of glutamatergic synaptic transmission in the prelimbic medialprefrontal cortex via delta-opioid receptors

Daisuke Yamada1, Keita Iio2, Hiroshi Nagase2, Akiyoshi Saitoh1

1Lab Pharmacol, Fac Pharm Sci, 2IIIS, Univ of Tsukuba

Oral Sessions


3-O-E1-3

Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induceddepression-like behavior through inhibition of indoleamine 2,3-dioxygenase1 expression in mice

Kazuo Kunisawa1, Willy Jaya Suento2,3, Bolati Wulaer2,4, Aika Kosuge1, Tsubasa Iida1,Hidetsugu Fujigaki2, Yasuko Yamamoto2, Andi Jayalangkara Tanra3, Kuniaki Saito2,4,5,Toshitaka Nabeshima4,5, Akihiro Mouri1,5

1Fujita Health University Graduate School of Health Science Department of Regulatory Science for Evaluation &Development of Pharmaceuticals & Devices, 2Fujita Health University Graduate School of Health ScienceDepartment of Disease Control and Prevention, 3Hasanuddin University Faculty of Medicine Department ofPsychiatry, 4Fujita Health University Graduate School of Health Science Advanced Diagnostic System ResearchLaboratory, 5Japanese Drug Organization of Appropriate Use and Research

Oral Sessions


3-O-E1-4

Involvement of Dysfunction of Noradrenergic Neuronal System in theDepression-Like Behaviors in MAGE-D1 KO Mice

Akihiro Mouri1,6, Mami Hirakawa1, Misato Yokoyama2, Ken Watanabe3, Mari Kimura2,Ryosuke Isobe1, Kazuo Kunisawa1, Yuko Mori4, Yasuko Yamamoto4, Yukihiro Noda2,6,Kuniaki Saito4,6, Toshitaka Nabeshima5,6

1Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Div. Clin. Sci. and Neuropsychopharm., MeijoUniv. Grad. Sch. Pharm., 3Dept. Bone and Joint Dis., Natl. Ctr. for Geriatrics and Gerontol., 4Dept. DiseaseControl & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 5Dept. Disease Control & Prevention., Grad.Sch. Health Sci., Fujita Health Univ., 6NPO.J-DO.

Oral Sessions


3-O-E2-1

Nicotine attenuated chronic unpredictable mild stress-induced depressive-like behavior via elevation of serum corticosterone level

Masaya Hasegawa1, Akihiro Mouri1,4, Kazuo Kunisawa1, Hisayoshi Kubota1, Hitomi Kurahashi1,Yasuko Yamamoto2, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,4

1Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.Sch. Health Sci., Fujita Health Uni., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,4NPO. J-DO

Oral Sessions


3-O-E2-2

Depression-like behaviors induced by chronic social defeat stress inassociation with myelin abnormalities in the corpus callosum throughmicroglial activation.

Sugawara Yumika1, Kazuo Kunisawa1, Tsubasa Iida1, Sei Saitoh2, Aika Kosuge1, Wulaer Bolati3,4,Yasuko Yamamoto3, Kuniaki Saito3,4,5, Akihiro Mouri1,5, Toshitaka Nabeshima3,5

1Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Anatomy II and Cell Biology, Sch.Medicine, Fujita Health Univ, 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ., 4Dept.Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 5NPO.J-DO.

Oral Sessions


3-O-E2-3

Multiple spatiotemporal patterns of social stress-induced epigeneticregulations in microglia

Masayuki Taniguchi1, Kazutoshi Matsushita1, Rei Mishima1, Shiho Kitaoka1, Shigehiro Kuraku2,Mitsutaka Kadota2, Tomoyuki Furuyashiki1

1Division of Pharmacology, Kobe University Graduate School of Medicine, 2Laboratory for Phyloinformatics,RIKEN Center for Biosystems Dynamics Research

Oral Sessions


3-O-E2-4

Chronic social stress alters iron metabolism for resilience

Shiho Kitaoka1, Taichi Tamura1, Yoshio Katayama2, Tomoyuki Furuyashiki1

1Div. Pharmacol., Grad. Sch. Med., Kobe Univ,2Dep. Hematol., Med., Kobe Univ

Oral Sessions


3-O-E3-1

Effects of early life stress on emotional behavior and hippocapal function inadolescent

Hyodo Risa, Sara Nannno, Akari Nishiyama, Taiga Akuhara, Eri Segi-Nishida

Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci.

Oral Sessions


3-O-E3-2

The role of neurotrophin-3 in the hippocampal neurogenesis and maturation-related phenotypes

Kasakura Nanami1, Yuka Murata1, Ryota Someya1, Shiho Kitaoka2, Tomoyuki Furuyashiki2,Eri Segi-Nishida1

1Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci,2Div of Pharmacol., Grad. Sch. of Med., Kobe Univ.

Oral Sessions


3-O-E3-3

Roles of TRPC3 and TRPC6 in the medial prefrontal cortex in theantidepressant-like actions of ketamine

Satoshi Deyama, Katsuyuki Kaneda

Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.

Oral Sessions


3-O-E3-4

The protective effect of flesinoxan on myelin damage caused bymaladaptation to stress in mice

Kazuhiro Kurokawa1, Kohei Takahashi1, Kazuya Miyagawa1, Atsumi Mochida-Saito1,Hiroshi Takeda2, Minoru Tsuji1

1Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare,2Dept. Pharmacol., Sch. Pharm. Fukuoka, Int. Univ.Health and Welfare

Oral Sessions


3-O-E3-5

The positive effect of Hypoxia-inducible factor on peripheral nerveremyelination.

Yuka Ujiie-Kobayashi, Shuji Wakatsuki, Toshiyuki Araki

Dept. of Peripheral Nervous System Res., NCNP

Oral Sessions


3-O-E4-1

Hypo-serotonergic function is involved in the prenatal valproic acid-inducedbehavioral changes and hyper-excitation in the prefrontal cortex of mice

Kurahashi Hitomi1, Mouri Akihiro1,4, Kunisawa Kazuo1, Kubota Hisayoshi1, Hasegawa Masaya1,Yamamoto Yasuko2, Saito Kuniaki2,3,4, Nabeshima Toshitaka3,4

1Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.Sch. Health Sci., Fujita Health Univ., 3Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.,4NPO. J-DO

Oral Sessions


3-O-E4-2

Intranasal oxytocin administration improves impaired social behavior in thePOGZ-Q1038R mutant mice

Kitagawa Kohei1, Kensuke Matsumura1, Masayuki Baba1, Momoka Kondo1, Tomoya Takemoto1,Kazuki Nagayasu1,2, Yukio Ago1,3, Atsushi Kasai1, Kazuhiro Takuma4,5, Hitoshi Hashimoto1,4,6,7,8,Takanobu Nakazawa1,9

1Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Lab. Mol. Pharmacol., Grad. Sch.Pharmaceut. Sci., Kyoto Univ., 3Lab. Cell. & Mol. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ.,4United Grad. Sch. Child Dev., Osaka Univ., 5Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., 6Div. Biosci., Inst.Datability Sci., Osaka Univ., 7Transdimensional Life Imaging Div., Inst. Open Transdiscip. Res. Initiatives, OsakaUniv, 8Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., 9Dept. Biosci., Tokyo Univ. Agr.

Oral Sessions


3-O-E4-3

Behavioral changes in rats neonatally treated with midazolam: deficits in thesociability and its recovery by acute administration of methylphenidate.

Niikura Ryo1, Akiko Doi1, Tomoyuki Miyazaki1, Kenkichi Takase2, Takahisa Goto1

1Dept. Anesth. Crit. Care Med., Yokohama City Univ.,2Sch. Med., Jichi Med. Univ.

Oral Sessions


3-O-E4-4

Local injection of D-amino acid oxidase inhibitor into the prefrontal corteximproves AD/HD-like behaviors of SHRSP/Ezo.

Hiroki Shikanai, Tsugumi Shindo, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi

Dept. Pharmacol., Health Sci. Univ. Hokkaido.

Oral Sessions


3-O-E5-1

Therapeutic potential of 5-HT2C receptor antagonism for obsessive-compulsive disorder.

Hatakama Hikari1, Nozomi Asaoka2, Kazuki Nagayasu1, Hisashi Shirakawa1, Shuji Kaneko1

1Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2Dept. Phamacol., Grad. Sch. Med. Sci., KyotoPref. Univ. Med.

Oral Sessions


3-O-E5-2

Striatal TRPV1 activation by acetaminophen improves tardive dyskinesiainduced by dopamine D2 receptor blockers

Koki Nagaoka1, Takuya Nagashima1, Nozomi Asaoka2, Hiroki Yamamoto1, Chihiro Toda1,Gen Kayanuma1, Soni Siswanto1, Kazuki Nagayasu1, Hisashi Shirakawa1, Shuji Kaneko1

1Dept. Mol. Pharmacol., Grad. Sch. Pharmceut. Sci., Kyoto Univ., 2Dept. Pharmacol., Grad. Sch. Med., Kyoto Pref.Univ. Med.

Oral Sessions


3-O-E5-3

withdraw

Oral Sessions


3-O-E5-4

INTERACTION BETWEEN CHOLINERGIC AND OPIOID SYSTEMS INALCOHOL SEEKING BEHAVIOR

Anggadiredja Kusnandar

Dept. Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung

Oral Sessions


3-O-E5-5

Animal model for donepezil-induced nausea and vomiting using picabehavior in mice

Kouichi Yamamoto1, Yuhki Sato2, Kyosuke Kirikihira1, Akito Jotaki1, Ayana Michihara2,Yumi Miyake2

1Dept Med Sci Tech, Div Health Sci, Sch Med, Osaka Univ,2Dept Physical Pharmaceutics, Fukuyama Univ

Oral Sessions


3-O-F4-1

5-hydroxytryptophan supplement recovers impaired platelet aggregation inQuinonoid dihydropteridine reductase deficient mice

Yui Suganuma1, Taiki Kano1, Kazuhisa Ikemoto1, Chiho Sumi-Ichinose1, Hiroshi Ichinose2,Kazunao Kondo1

1Dept. Pharmacol., Sch. Med., Fujita Health Univ., 2Sch. Life Sci. Tech., Tokyo Tech.

Oral Sessions


3-O-F4-2

Human aortic valve interstitial cells obtained from patients with calcifiedaortic valve stenosis are VEGFR2 positive and contribute to ectopiccalcification

Zaiqiang Yu1, Xu Liu1, Kazuyuki Daitoku1, Ikuo Fukuda1, Shigeru Motomura2,Tadaatsu Imaizumi3, Ken-Ichi Furukawa4, Tomoh Matsumiya3, Kazuhiko Seya3

1Dept. Thorac. Cardiovasc. Surg., 2Dept. Pharmacol., 3Dept. Vascul. Biol., 4Dept. Orthop. Surg.

Oral Sessions


3-O-F4-3

Anti-Cancer Agent Oxaliplatin Caused Erectile Dysfunction in Rats throughBoth Neural and Endothelial Dysfunction

Tomoya Kataoka1, Jun Suzuki2, Yuto Kawaki2, Yohei Kito2, Yuji Hotta2, Yoshihiro Kawade2,Yasuhiro Maeda3, Kazunori Kimura1,2

1Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University,2Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3Centerfor Joint Research Facilities Support, Fujita Health University

Oral Sessions


3-O-F4-4

Establishment of a novel experimental autoimmune vasculitis model

Takafumi Seo1, Shota Tanaka1, Makiko Maeda2, Masanori Obana1, Yasushi Fujio1

1Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Oral Sessions


3-O-F5-1

Recombinant soluble thrombomodulin reduces lipopolysaccharide-inducedendothelial cellular stiffening

Takayuki Okamoto1, Haruki Usuda1, Tetsuya Tanaka1,2, Koichiro Wada1

1Dept. Pharmacol., Fac. of Med., Shimane Univ., 2Dept. Human Nutrition, Fac., Contemporary Life Science,Chugoku Gakuen Univ.

Oral Sessions


3-O-F5-2

CXCL10 is an anti-angiogenic factor downstream of p53 in cardiomyocytes.

Ryuta Igarashi1, Masashi Tomimatsu1, Makiko Maeda1,2, Syota Tanaka1, Masanori Obana1,Yasushi Fujio1

1Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., 2Laboratory of ClinicalPharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Oral Sessions


3-O-F5-3

Amino acid transporter LAT1 is upregulated in tumor-associated vascularendothelial cells and plays essential roles in tumor angiogenesis bypromoting proliferation and regulating VEGF-A-dependent pro-angiogenicmTORC1 activation.

Ryuichi Ohgaki1,2, Lili Quan1, Suguru Okuda1, Hiroki Okanishi1, Shushi Nagamori3,Hitoshi Endou4, Yoshikatsu Kanai1,2

1Dept. Bio-sys Pharm., Grad. Sch. Med., 2Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ.,3Dept. Lab. Med.,Jikei Univ. Sch. Med., 4J-Pharma Co.,Ltd.

Oral Sessions


3-O-F5-4

Tctex-1 augments parathyroid hormone receptor-mediated Gs signaling byactivating adenylyl cyclase

Masaki Saito1,2, Ayano Chiba2, Takeya Sato1, Jun Sukegawa1,3

1Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med.,2Dept. Cellular Signalling, Grad. Sch. Pharmaceut. Sci.,Tohoku Univ.,3Dept. Hum. Health Nutr., Shokei Gakuin Univ.

Oral Sessions


3-O-F5-5

Global Regulation of Protein S-palmitoylation by Nitric Oxide

Naoko Adachi1, Douglas Hess2, Izumi Koganemaru1, Takehiko Ueyama1, Naoaki Saito1

1Biosignal Res. Ctr., Kobe University,2ITMM, Case Western Reserve University

Oral Sessions


3-O-G4-1

Mycobacterial protease clp as a promising anti-TB drug target

Takehiro Yamaguchi1, Yuriko Ozeki2, Sohkichi Matsumoto2, Kentaro Tokudome1,Shinji Matsunaga1, Shuhei Tomita1

1Phamacol., Osaka City Univ., 2Bacteriol., Niigata Univ.

Oral Sessions


3-O-G4-2

Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenalinesynthesis by affecting the redox status of the copper chaperone ATOX1

Masato Katsuyama1, Chihiro Yabe-Nishimura2

1Radioisotope Ctr., Kyoto Pref. Univ. Med.,2Dept. Pharmacol., Kyoto Pref. Univ. Med.

Oral Sessions


3-O-G4-3

From zebrafish to human: Rhamnan sulfate improves constipation withalteration of gut microbiota.

Yasuhito Shimada1,2,3, Hiroko Nakayama3,4, Fumiyoshi Okazaki2,3,5, Liqing Zang3,4,Masahiro Terasawa3,6, Koichi Mastuda6, Kaoru Nishiura6, Ryota Uchida6, Norihiro Nishimura3,4

1Dept. Int Pharm., Grad. Sch. Med., Mie Univ., 2Mie Univ. Adv. Sci. Res. Cen., Bioinfo.,3Mie Univ. Zebrafish DrugScreen. Cen., 4Grad. Sch. Reg. Innov., Mie Univ., 5Grad. Sch. Bioresource, Mie Univ., 6Konan ChemicalManufacturing Co., Ltd

Oral Sessions


3-O-G4-4

Sorghum (Sorghum bicolor L.Moench) extract enhances thiazolidinediones-induced 3T3-L1 preadipocyte differentiation but inhibits adipogenic genes

Makoto Sakurai1, Ikumi Aizu1, Yuko Oba1, Marina Tonosaki1, Mei Nagata2, Katsuyoshi Kamiie2,Atsuko Masumi1

1Dept. Mol.Pharmacol. Pharm.Sci. Aomori Univ., 2Dept. Mol.Biol. Pharm.Sci. Aomori Univ.

Oral Sessions


3-O-G5-1

Mitotic ER exit site disassembly and reassembly are regulated by thephosphorylation status of TANGO1

Maeda Miharu, Yukie Komatsu, Kota Saito

Dept. Biol. Inform. and Exp. Therap., Grad Sch. of Med., Akita Univ

Oral Sessions


3-O-G5-2

Axonal targeting of TrkA-APP complex via transcytosis

Naoya Yamashita, Takashi Sakurai

Dept. of Cell and Mol Pharmacol., Juntendo Univ., Sch. Med.

Oral Sessions


3-O-G5-3

Ubiquitin ligase RNF183 promotes the lysosomal degradation of NKCC1under hypertonic conditions

Masayuki Kaneko1,2, Takumi Okamoto1,2, Kazunori Imaizumi2

1Dept. Pharmacol. Therap. Innov., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Dept. Biochem., Grad. Sch. Biomed. &Hlth. Sci., Hiroshima Univ.

Oral Sessions


3-O-G5-4

Probiotic ferrichrome exhibited the anti-tumor effect mediating theendoplasmic stress pathway in colorectal cancer cells

Hiroaki Konishi1, Takuya Iwama2, Hiroki Tanaka3, Shotaro Isozaki2, Chikage Yamamura2,Satoshi Ichikawa5, Kentaro Moriichi2,4, Mikihiro Fujiya1,2,4

1Dept. Gastroenterol & Adv Med Sci, Asahikawa Med Univ,2Dept. Med, Asahikawa Med Univ, 3Dept. Pathol,Asahikawa Med Univ, 4Joint Res Dept. Telemed & Telecare, Asahikawa Med Univ,5Cent. Res. & Educ. DrugDiscov, Fac. Pharmaceut. Sci, Hokkaido University

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3-O-G5-5

SIRT1, a histone deacetylase, mediates the proper DNA damage responsevia histone H2AX deacetylation in the cardiomyocyte.

Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio

Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

Oral Sessions


3-o-b1-1 oral sessions analyses of forming hetero ...intranasal oxytocin administration improves...

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