3rd Annual Global Summit on

GENITOURINARYO CTOBER 10-13 , 2019BANFF | CANADA

MALIGNANCIES

OMILogo

SUMMIT CHAIRS:Daniel Petrylak, MDYale UniversityNew Haven, CT

Charles Ryan, MDUniversity of MinnesotaMinneapolis, MN

Oliver Sartor, MDTulane Medical SchoolNew Orleans, LA

For more information and to REGISTER visit: http://bit.ly/BANFFGU2019

3rd Annual Global Summit on

GENITOURINARY MALIGNANCIESO CTOBER 10-13 , 2019

BANFF | CANADA

NIMIRA ALIMOHAMED, MD, FRCPCClinical Associate ProfessorDepartment of OncologyCumming School of MedicineUniversity of CalgaryCalgary, Alberta, Canada

PEDRO BARATA, MD, MSC Assistant Professor of MedicineInternal Medicine/Hematology-Oncology Section/Genitourinary

Cancers Tulane Cancer CenterNew Orleans, LA

PASQUALE BENEDETTO, MDProfessorSylvester Comprehensive Cancer CenterUniversity of MiamiMiami, FL

MATTHEW R. COOPERBERG, MD, MPHProfessor of Urology and Epidemiology & BiostatisticsAssociate Chair, Clinical Research, Department of UrologyHelen Diller Family Chair in UrologyUniversity of California, San FranciscoSan Francisco, CA

HAMID EMAMEKHOO, MDAssistant ProfessorUniversity of Wisconsin Carbone Cancer CenterUniversity of Wisconsin School of Medicine and Public HealthMadison, WI

ANNA C. FERRARI, MDProfessor of Medicine, OncologyAlbert Einstein College of MedicineMontefiore Medical CenterBronx, NY

TERENCE FRIEDLANDER, MDAssociate Professor of MedicineUCSF Medical CenterSan Francisco, CA

PETROS GRIVAS, MD, PHDAssociate ProfessorClinical Director of Genitourinary Cancers ProgramFred Hutchinson Cancer Research CenterUniversity of WashingtonSeattle, WA

HANS HAMMERS, MD, PHDAssociate ProfessorThe University of Texas Southwestern Medical CenterDallas, TX

CELESTIA HIGANO, MD, FACPProfessor of MedicineUniversity of WashingtonSeattle, WA

ANDREW HONG, MDInstructor of PediatricsHarvard Medical SchoolDana-Farber Cancer InstituteBoston, MA

ROHIT JAIN, MBBS, MPHAssistant Member, Department of Genitourinary OncologyMoffitt Cancer CenterTampa, FL

ERIC JONASCH, MDProfessor of MedicineUniversity of Texas MD Anderson Cancer CenterHouston, TX

ANIL KAPOOR, MD, FRCSCDirector, Urologic Cancer Centre for Research & Innovation Head, Genito-Urinary Oncology Program Juravinski Cancer CentreProfessor of Surgery (Urology) and OncologyMcMaster UniversityHamilton, Ontario, Canada

STACEY KENFIELD, SCDAssociate Professor of UrologyHelen Diller Family Chair in Population Science for Urologic

CancerDepartment of UrologyUniversity of California, San FranciscoSan Francisco, CA

DEEPAK KILARI, MDAssociate ProfessorMedical College of WisconsinMilwaukee, WI

JOSEPH KIM, MDAssociate ProfessorYale UniversityNew Haven, CT

VADIM S. KOSHKIN, MDAssistant ProfessorUniversity of California, San FranciscoSan Francisco, CA

FACULTY

3rd Annual Global Summit on

GENITOURINARY MALIGNANCIESO CTOBER 10-13 , 2019

BANFF | CANADA

NEYSSA MARINA, MDExecutive Medical DirectorSynthorxLa Jolla, CA

BENJAMIN MAUGHAN, MD, PHARMDAssistant Professor, Division of Medical OncologyHuntsman Cancer InstituteUniversity of UtahSalt Lake City, Utah

ALICIA K. MORGANS, MD, MPHAssociate Professor of MedicineNorthwestern University Feinberg School of MedicineChicago, IL

RON PECK, MDChief Medical OfficerArvinasNew Haven, CT

DANIEL PETRYLAK, MD CHAIRProfessor of MedicineCo-Director, Signal Transduction Research ProgramYale UniversityNew Haven, CT

ARPIT RAO, MDAssistant Professor, Division of Hematology, Oncology and

TransplantationChair, M Health/Fairview Oncology Quality and Safety

CommitteeUniversity of Minnesota Masonic Cancer CenterMinneapolis, MN

CHARLES RYAN, MD CHAIRProfessor of MedicineBJ Kennedy Professor of Clinical Cancer ResearchDirector, Division of Hematology, Oncology, and

TransplantationAssociate Director, Masonic Cancer CenterUniversity of MinnesotaMinneapolis, MN

OLIVER SARTOR, MD CHAIRC.E. and Bernadine Laborde Professor of Cancer ResearchMedical Director, Tulane Cancer CenterTulane Medical SchoolNew Orleans, LA

ABHISHEK SOLANKI, MDAssistant ProfessorDirector of Clinical Research & Quality Medical DirectorDepartment of Radiation OncologyStritch School of Medicine, Loyola UniversityMaywood, IL

SRIKALA SRIDHAR, MD, MSC, FRCPCAssociate ProfessorPrincess Margaret Cancer CenterToronto, Ontario, Canada

WALTER STADLER, MD, FACPFred C. Buffett ProfessorDepartments of Medicine & SurgeryDean for Clinical ResearchDeputy Director, Comprehensive Cancer CenterUniversity of Chicago Medicine & Biological SciencesChicago, IL

WILLIAM TESTER, MD, FACP Clinical Professor of Medical OncologyMedical Director of Outpatient OperationsJefferson Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphia, PA

ULKA VAISHAMPAYAN, MDProfessor of OncologyChair, Solid Tumor Oncology and Eisenberg Phase I CenterCharles Martin Endowed ChairKarmanos Cancer CenterWayne State UniversityDetroit, MI

CHRISTOPHER WEIGHT, MDDirector, Urologic Oncology FellowshipAssociate ProfessorDepartment of UrologyUniversity of MinnesotaMinneapolis, MN

ALEXANDER WYATT, PHDSenior Research ScientistVancouver Prostate CentreAssistant Professor, Department of Urologic SciencesUniversity of British ColumbiaVancouver, British Columbia, Canada

HARIS ZAHOOR, MDAssistant Professor of Clinical MedicineKeck School of MedicineUniversity of Southern CaliforniaLos Angeles, CA

FACULTY

3rd Annual Global Summit on

GENITOURINARY MALIGNANCIESO CTOBER 10-13 , 2019

BANFF | CANADA

Thursday, October 10, 20195:45 PM Welcome and Introductions

KEYNOTE ADDRESS

6:00 PM GU Malignancies: Perspectives and a Peer Into the Future

Eric Jonasch

SETTING THE STAGE

Moderator: Charles Ryan 6:30 PM Can We Make Prostate Cancer a

Chronic Disease?TBD

6:45 PM Can We Cure Metastatic Renal Cell Carcinoma?

Hans Hammers

7:00 PM How Do We Integrate New Therapies into the Treatment of Bladder Cancer?

Walter Stadler

7:15 PM Next Steps for Immunotherapy in GU Malignancies

Srikala Sridhar

7:30 PM Using Genomics to Select Patients for Organ Preservation

William Tester

7:45 PM DISCUSSION8:00 PM ADJOURN TO WELCOME RECEPTION

Friday, October 11, 20196:00 AM BREAKFAST

ADVANCES IN IMAGING AND SURGERY

Moderator: Oliver Sartor 7:00 AM Non-invasive Monitoring of Urothelial

CancersTBD

7:15 AM New Perspectives in PET Imaging in Prostate Cancer

Oliver Sartor

7:30 AM Deep Learning in Kidney Cancer Imaging: How AI Will Revolutionize Kidney Cancer Care

Christopher Weight

7:45 AM DISCUSSION8:00 AM The Role of Genomic Risk in Prostate

Cancer Surveillance Matthew

Cooperberg8:15 AM The Role of Nephrectomy in the Age

of Modern TherapeuticsUlka

Vaishampayan8:30 AM DISCUSSION8:45 AM BREAK

PROGRESS IN RENAL CELL CARCINOMA THERAPIES

Moderator: Charles Ryan 9:05 AM How to Choose First-line Therapy for

RCCHaris Zahoor

9:20 AM Anti-tumor Activity of Small Molecule Glutaminase Inhibitors

TBD

9:35 AM Next-generation Immunotherapy in RCC

Hans Hammers

9:50 AM DISCUSSION

NOVEL TARGETS AND APPROACHES FOR GU MALIGNANCES

Moderator: Daniel Petrylak 10:05 AM Novel Immunoconjugates in Bladder

CancerSrikala Sridhar

10:20 AM PSMA Targeted Therapies in Advanced Prostate Cancer

Oliver Sartor

10:35 AM Using Synthetic Biology to Design and Manufacture Optimized Medicines for the Treatment of Cancer

Neyssa Marina

10:50 AM DISCUSSION11:10 AM Targeting the DNA Repair Pathway Charles Ryan11:25 AM Development of an Androgen

Receptor PROTAC® in Prostate Cancer

Ron Peck

11:40 AM Targeting PTEN Loss and PI3K in Prostate Cancer Therapeutics

Pedro Barata

11:55 AM DISCUSSION12:15 PM ADJOURN

DEBATING TECHNOLOGY: IS THERE A ROLE FOR CHEMOTHERAPY IN METASTATIC CSPC?Moderator: Charles Ryan

5:00 PM Hormonal Therapy: The Future of mCSPC Treatment

TBD

5:10 PM Chemotherapy is Not Dead in Prostate Cancer

TBD

5:20 PM DISCUSSION

THE SPECTRUM OF METASTATIC DISEASE IN PROSTATE CANCERModerator: Oliver Sartor

5:40 PM Defining Oligometastatic Disease in Prostate Cancer

TBD

5:55 PM The Role of Treating the Primary in Metastatic Prostate Cancer

Matthew Cooperberg

6:10 PM Stereotactic Body Radiation Therapy in Oligometastatic Cancer

Abhishek Solanki

6:25 PM DISCUSSION6:40 PM BREAK

TARGETED THERAPY IN BLADDER CANCERModerator: Daniel Petrylak

7:00 PM Neoadjuvant Therapy for Muscle Invasive Bladder Cancer

Deepak Kilari

7:15 PM Targeting the IL2 Pathway to Engage the Immune Response

TBD

7:30 PM Targeting FGFR in Bladder Cancer Petros Grivas7:50 PM Emerging Agent Showcase: Mirati

TherapeuticsTBD

8:05 PM DISCUSSION8:30 PM ADJOURN TO POSTER RECEPTION

3rd Annual Global Summit on

GENITOURINARY MALIGNANCIESO CTOBER 10-13 , 2019

BANFF | CANADA

Saturday, October 12, 20196:00 AM BREAKFAST

SETTING THE STAGE

7:00 AM The Era of Personalized Therapy for GU Tumors

TBD

THE ROLE OF IMMUNO AND RADIOTHERAPY

Moderator: Charles Ryan

7:15 AM VEGFR TKI and PD-1/PD-L1 Combinations for First-line RCC

Hamid Emamekhoo

7:30 AM Immunotherapy in Prostate Cancer TBD7:45 AM Immune Checkpoint Inhibitors

and Cytokine Combinations in GU Malignancies

Rohit Jain

8:00 AM Combination Immunotherapy and Radiotherapy in Bladder Cancer

Abhishek Solanki

8:15 AM PSMA-Targeting Radioligand Therapy in Prostate Cancer

Vadim Koshkin

8:30 AM DISCUSSION8:50 AM BREAK

LEARNING FROM GENOMICS AND BIOMARKERS

Moderator: Daniel Petrylak 9:10 AM The Relationship Between the

Microbiome and GU MalignanciesCharles Ryan

9:25 AM Molecular Assessments of Resistance to Hormonal Therapies in Prostate Cancer

Benjamin Maughan

9:40 AM Epigenetic Modulation of Antiandrogen Resistance

Anna Ferrari

9:55 AM DISCUSSION10:10 AM Assessing Biomarkers for Bladder

CancerPetros Grivas

10:25 AM Non-invasive Genotyping and Stratification using Cell-free DNA

Alexander Wyatt

10:40 AM Utility of Circulating Tumor Cells in GU Malignancies

Terence Friedlander

10:55 AM DISCUSSION

TARGETING THE ANDROGEN RECEPTOR IN PROSTATE CANCER

Moderator: Oliver Sartor 11:10 AM Evolution of Androgen Receptor

Alterations During Sequential Inhibition

Alexander Wyatt

11:35 AM Role of AR-V7 in Sequencing Therapeutic Agents for CRPC

TBD

11:50 AM Strategies for Targeting the Androgen Receptor Axis in Prostate Cancer

Ulka Vaishampayan

12:05 PM Apalutamide: New Approaches and Future Directions

TBD

12:20 PM DISCUSSION12:40 PM ADJOURN

DEBATING TECHNOLOGY: IS THERE A ROLE FOR IMMUNE THERAPY FOR UROTHELIAL PATIENTS WITH VISCERAL DISEASE?Moderator: Daniel Petrylak

5:00 PM The Promise of Immunotherapy in Urothelial Cancer

TBD

5:15 PM Fighting Urothelial Cancer without Immunotherapy

TBD

5:30 PM DISCUSSION

ADDRESSING THERAPEUTIC CHALLENGES IN GU MALIGNANCIES

Moderator: Oliver Sartor 5:50 PM The Potential of High-dose

Testosterone: Re-sensitizing Patients to Hormonal Therapy

Pedro Barata

6:05 PM Addressing Neuroendocine Differentation in Prostate Cancer

TBD

6:20 PM Clinical Development of PARP Inhibitors for Genitourinary Cancers

TBD

6:35 PM Future of mTOR Inhibitors in GU Malignancies

Joseph Kim

6:50 PM DISCUSSION

QUALITY OF LIFE AND OUTCOME CONSIDERATIONS FOR GU MALIGNANCIESModerator: Charles Ryan

7:10 PM Women and Bladder Cancer: Unique Needs and Special Strategies

Alicia Morgans

7:25 PM Diet and Lifestyle Modifications in Prostate Cancer

Stacey Kenfield

7:40 PM New Perspectives in Non-metastatic CRPC

Celestia Higano

7:55 PM Quality of Life as an Outcome in Prostate Cancer

Alicia Morgans

8:10 PM DISCUSSION8:30 PM ADJOURN

Sunday, October 13, 2019ORAL ABSTRACTS

7:00 AM Oral Abstract 17:15 AM Oral Abstract 27:30 AM Oral Abstract 37:45 AM Oral Abstract 48:00 AM Oral Abstract 58:15 AM Oral Abstract 68:30 AM MEETING CONCLUDES