408

gens are non-reactive in animals and humans and effective b.~ parenteral admimstration, the immunosuppression being antigen specific, af- fecting production of immunoglobulins. A method of producing immunosuppressive poly- peptide fractions and a method of desensitizing mammals therewith are disclosed.

4469679

PATENT ABSTRACTS

to greater inactivation kinetms, when the cells originated from individuals affected by the dis- ease or capable of transmitting It, than when said cells were from healthy people. The process thus consists of maintaining such cells, either in natural biological media or in culture media at a temperature within said intervals for a time long enough to appreciate the degree or kinetics of in- activation which can then be correlated to the fact that the individual is either healthy or af- fected by the disease or liable of transmitting it.

O C T A P E P T I D E V A S O P R E S S I N A N T A G O N I S T S

William F Huffman, Michael Moore assigned to SmithKline Beckman Corporation

Certain octapeptides which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail have vasopressin an- tagonist activity. An important species of the group is (1-( beta-mercapto- beta, beta- cyclopentamethylenepropionic acid)-2-(O- ethyl-D-tyrosine)-4-valine-8-arginine-9- desglycine)vasopressin.

4469680

I O D I N A T E D V A S O P R E S S I N A N T A G O N I S T S

William F Huffman, Michael Moore assigned to SmithKline Beckman Corporation

A series of vasopressin antagonists which have a 3"-iodo-tyrosine unit at position 2 are prepared by inclination of the tyrosine congeners. The compounds have antagonist activity manifested by an aquaretic effect and, also, are useful in studying various biological reactions.

4469790

C O N T I N U O U S A N D S P O N T A N E O U S I N T E R F E R O N

P R O D U C I N G L Y M P H O B L A S T O I D C E L L L I N E S , P R O C E S S F O R

P R E P A R I N G T H E S A M E , A N D P R O C E S S F O R T H E H U M A N

I N T E R F E R O N P R O D U C T I O N BY T H E S A M E

lsao Yamane. Takeshi Sato. Toshio Kudo, Yoshiki Minamoto, Takehiko Tachibana, Sen- dai, Japan assigned to Ajinomoto Co Inc

Process for preparing a continuous and spon- taneous human-interferon-producing lympho- blastoid cell line which involves (a) transforming human lymphocytes isolated from a human in- fant from birth up to about 2 years or an aborted human fetus, the transforming being carried out with Epstein Barr Virus and (b) selecting from the resulting transformed cell lines a cell line pro- ducing more than 1000 units of interferon per milliliter when cultivated at a cell density of 106 cells per milliliter in the absence of any interferon inducer.

4469788

P R O C E S S O F I N V I T R O D I A G N O S I S O F C Y S T I C F I B R O S I S

Peter Hosli, Paris, France assigned to Institut Pasteur

The invention relates to an in vitro process for diagnosing cystic fibrosis, which brings into play conditions, particularly temperatures at which some of the hydrolases released by the cells from the individual under study, particularly alpha- mannosidase and acid phosphatase, are subject

4469863

N O N I O N I C N U C L E I C A C I D A L K Y L A N D A R Y L

P H O S P H O N A T E S A N D P R O C E S S E S F O R

M A N U F A C T U R E A N D U S E T H E R E O F

Paul O Ts'o. Paul S Miller

Oligonucleoside alkyl- or aryl phosphonates are nonionic analogues of nucleic acid which possess