PATENT ABSTRACTS 343

4557933

A N T I B I O T I C C A L L E D C H L O R O P O L Y S P O R I N , A

P R O C E S S F O R I T S P R E P A R A T I O N , A N D I T S

T H E R A P E U T I C A N D V E T E R I N A R Y U S E

Tatsuo Haneishi, Takao Okazaki, Akio Torikata, Mutsuo Nakajima, Ryuzou Enokita, Toshiaki Katayama, Seigo lwado, Hiromachi, Japan assigned to Sankyo Company Limited

A novel compound, called chloropolysporin, has antibiotic properties and would appear to be a member of the class of glycopeptide antibiotics containing chlorine. It may be produced by cul- tivating a suitable strain of microorganism of the genus Micropolyspora, especially Micro- polyspora sp. SANK 60983 (FERM BP-538). It may be combined with conventional pharma- ceutically acceptable carriers or diluents for therapeutic use or incorporated into edible ex- cipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

4559229

A V I A N P R O V E N T R I C U L I T I S V A C C I N E

Robert K Page, Pedro Villegas, Casweil Eidson, Danie Gaudry assigned to Research Foundation

A process of preparing a vaccine capable of pro- tecting poultry against avian proventriculitis which comprises: separating proventriculitis reovirus from reovirus-carrying tissue of a poultry animal diseased with proventriculitis; in- oculating a cell culture capable of sustaining the growth and replication of the reovirus; extra- cting the virus from cellular and nonviral com- ponents, and rendering the reovirus into a form suitable for administration to poultry, yields a vaccine and an immunization method.

4559306

Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bac- teria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.

4559338

S O L U B L E Q U I N A Z O L I N O - I , 4 - B E N Z O D I A Z E P I N - 5 , 1 3 - D I O N E

D E R I V A T I V E S

Mark G Bock, Roger M Freidinger, Ben E Evans assigned to Merck & Co Inc

Novel quinazolino- 1,4-benzodiazepin-5,13- dione derivatives, which are soluble in aqueous media and which have been found to be an- tagonists of the function of cholecystokinins (CCK), to the preparation of these compounds from compounds prepared by aerobic fermenta- tion of certain Aspergillus alliaceus strains, and to the use of these compounds to antagonize the function of CCK, which antagonism is useful, e.g., for the treatment and prevention of dis- orders of the gastrointestinal, central nervous and appetite-regulatory systems of mammals, especially of humans.

4559339

I N D O L - 3 - Y L - Q U I N A Z O L I N O - 1 , 4 - B E N Z O D I A Z E P I N - 5 , 1 3 - D I O N E S

Mark G Bock, Roger M Freidinger, Ben E Evans assigned to Merck & Co lnc

Novel indol-3-yl-quinazolino- 1,4- benzodiazepin-5,13-diones, which are an- tagonists of the function of cholecystokinins (CCK), to the preparation of these compounds from compounds prepared by aerobic fermenta- tion of certain Aspergillus alliaceus strains, and to the use of these compounds to antagonize the function of CCK, which antagonism is useful, e.g., for the treatment and prevention of dis- orders of the gastrointestinal, central nervous and appetite-regulatory systems of mammals, especially of humans.

M O D I F I E D P A S T E U R E L L A M U L T O C I D A B A C T E R I A

Carrell J Kucera assigned to Norden Laboratories inc

The chemical modification of virulent

4560552

A N T I B I O T I C S

Martin Cole, Thomas T Howarth, Christopher Reading, Dorking, United Kingdom assigned to Beecham Group p I c