Gen. Pharmac. Vol. 18, No. I, pp . i - v i i i , 1987 Pergamon Journals Ltd. Printed in Great Britain

NEW PATENTS

This Section contains abstracts (without graphics) of recently issued United States patents and published patent applications filed from over 30 countries under the Patent Cooperation Treaty. This information was obtained from recent additions to the Pergamon PATSEARCH ® online database in accordance with interest profiles developed by the Editors. Further information about Pergamon PATSEARCH ® can be obtained from Pergamon InfoLine Inc., 1340 Old Chain Bridge Road, McLean, Virginia 22101 U.S.A.

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4564522

PHARMACEUTICAL PREPARATIONS AND

COMPOSITIONS

Dennis Rocke, London, United Kingdom as- signed to Shelleden Products Limited

A pharmaceutical composition characterized in that it comprises (a) Vitamin A, (b) one or more tochopherols (c) an oil of the genus prunus, and (d) an oil of the genus sesamum; in that the weight of each of (c) and (d) is between 5 and 75 times the weight of (a); in that the weight of each of (c) and (d) is between 4 and 125 times the weight of (b); and in that the composition has a consistency suitable for topical application.

4564620

5,6,7,-TRINOR-4,8-INTER-M- PHENYLENE PGI2 DERIVATIVES

AND ANTI-ULCER, ANTI- THROMBOTIC AND ANTI-

HYPERTENSIVE PHARMACEUTICAL

COMPOSITIONS CONTAINING THEM

Kiyotaka Ohno, Hiroshi Nagase, Mamoru Ishikawa, Kazuhis Matsumoto, Shintaro Nishio, Fujisawa, Japan assigned to Toray Industries Inc

Pharmaceutically useful compounds are 5,6,7- trinor-4,8-inter-m-phenylene PGI2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13, 14-didehydro PGI2, 5,6,7-trinor-4,8-inter-m- phenylene-16,16-dimethyl PGI2, 5,6,7-trinor- 4,8-inter-m-phenylene- 17- alpha-methyl-20-

homo PGI2, 5,6, 7-trinor-4,8-inter-m- phenylene- 17,18,19,20-tetranor- 16-phenoxy PGI2, 5,6, 7-trinor-4,8-inter-m-phenylene-20- isopropylidene PGI2, 5,6,7-trinor-4, 8-inter-(5- methyl-l,3-phenylene) PGI2, and 5,6,7-trinor-4, 8-inter-m-phenylene-2,3-didehydro- 16,17,18,19,20-pentanor- 15-phenyl PGI2. They are useful in treatment of ulcers, thrombii and hypertension for example.

4564621

ALPHA-ARYL- ALPHA- PYRIDYLALKANOIC ACID

DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND

PHARMACEUTICAL COMPOSITION COMPRISING

THE SAME

Ikuo Ueda, Masanobu Nagano, Atsushi Akahane, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Co Ltd

New alpha-aryl- alpha-pyridylalkanoic acid derivatives of the formula: See Patent for Chem- ical Structure wherein R1 is cyano or carbamoyl, R2 is hydrogen or halogen, R3 is hydrogen or lower alkyl, one of R4 and R5 is hydrogen and another is lower alkyl, R6 is hydrogen or lower alkyl, and R7 is lower alkyl, or R6 and R7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl, provided that R2 is halogen or R3 is lower alkyl, when R1 is cyano and R6 and R7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition com- prising the same. These derivatives and salts thereof are useful as antiulcer agents and spas- molytic agents.