338 PATENT ABSTRACTS

4668821 4670396

M E T H O D F O R E X T R A C T I N G P H E N Y L A L A N I N E F R O M

B R O T H S O F B I O C O N V E R S I O N

V E R T I C A L C U L T U R E S Y S T E M W I T H R E M O V A B L E C U L T U R E

U N I T

Onorino G Rosa. Carl Varesio, Ernesto Oppici, To, Italy assigned to Farmitalia Carlo Erba S p A

The invention discloses a method for extracting phenylalanine from the broths obtained by en- zymatic processes; this method consists in floc- culating and filtering the broth, concentrating the filtrate followed by filtering off the resulting cinnamic acid, decolorating and concentrating the filtrate to obtain phenylalanine crystals at a very pure degree.

Mark P Bear, F Howard Schneider assigned to Bioassy Systems Corporation

A vertical culture system including a culture tube having an opening and a bottom opposite the opening and a removable culture unit which has a platform and an elongate handle for dis- posing the platform proximate the tube bottom and for permitting removal of the culture unit. The culture system also includes a culture subs- trate carried by the platform and closure means for sealing the tube. The culture system may fur- ther include a volume retention element disposed within the culture tube.

4670379

P O L Y N U C L E O T I D E H Y D R I D I Z A T I O N A S S A Y S E M P L O Y I N G C A T A L Y Z E D

L U M I N E S C E N C E

Jeffrey A Miller assigned to E I Du Pont de Nemours and Company

Polynucleotide hydridization assays employing catalyzed luminescence.

4670380

A S S A Y S U T I L I Z I N G L A B E L E D N U C L E I C A C I D P R O B E S

Nanibhushan Dattagupta assigned to Molecular Diagnostics Inc

In a method for determining a particular poly- nucleotide sequence in a test medium containing single stranded nucleic acids wherein the sample is subjected to a hybridization reaction with a labeled detection probe having a substantially complementary polynucleotide sequence, and wherein after hybridization the label in said probe is assayed, the improvement wherein the label in said labeled probe comprises a fluores- cent nucleotide which is linked by a phosphate ester linkage to said probe. Probes and kits there- for are also provided.

4670397

F E R M E N T A T I O N A P P A R A T U S

Eugene H Wegner, Harold Hunt assigned to Phillips Petroleum Company

Fermentation apparatus useful for conducting aerobic fermentations of microbial cells, par- ticularly at high productivities, is disclosed.

4670398

P L A N T T I S S U E C U L T U R E V E S S E L A N D F I L T E R

John S Song

A plant tissue culture vessel including a base and a mating cover wherein the base and cover in- clude means for adjustably setting the gas ex- change rate between the interior of the vessel and the ambient, and means for selectively defining a loose or tight fit between the cover and the base. The cover and base are made from a material that permits the transmission of light. A filter is provided between the mating parts of the cover and base to filter contaminants during all modes of relationship between the cover and the base. The filter is constructed from a foam urethane blank having a porosity capable of precluding the passage of dust, bacteria and virus and is for- med as an endless member by being cut in strip form from a blank of material and thereafter longitudinally slit between the ends.