790 PATENT ABSTRACTS

Immunological methods are disclosed for dia- gnosing active human neurocysticercosis, in- cluding a serum test and a cerebrospinal fluid test. The serum test involves detecting an anti- body in serum which recognizes at least one of three particular antigens isolated from Taenia solium larvae. The cerebrospinal fluid test in- volves detecting an antigen or antigens of larval origin, preferably by an ELISA technique.

4740458

R E A G E N T F O R A S S A Y I N G C R E A T I N E K I N A S E

Hitosh Kondo, Masao Kageyama, Kosuke Tomita, Kyoto, Japan assigned to Unitika Ltd

A reagent system for assaying creatine kinase is disclosed. The reagent system consisting essen- tially of a first reagent comprising glucose-6- phosphate dehydrogenase, beta- nicotinamideadenine dinucleotide (phosphate), and adenosine diphosphate, and a second rea- gent comprising creatine phosphate, said second reagent being maintained at a pH of from 7.5 to 10, and at least one of said first reagent and said second reagent containing glucokinase and glucose. The creatine kinase-assaying reagent ex- hibits remarkably improved stability in a dis- solved state so that it can be prepared in large quantities and can be conventionally utilized to cope with urgent clinical examinations.

4740476

I M M U N O A S S A Y F O R E S T R I O L - 3 - S U L F A T E

Akiko Kubodera, Touichi Tanaka, Matsudo, Japan assigned to Nihon Medi-Physics Co Ltd

A process for producing an antibody having a specificity to estriol-3-sulfate, which comprises administering a 6-substituted-estriol-3-sulfate protein conjugate of the formula: See Patent for Chemical Structure (I) wherein A is double bondN-O- or -O-CO-, n is an integer of I to 4 and -NH-P is the residue of a protein excluding a hydrogen atom in the amino form therefrom parenterally to a living body of a vertebrate animal so as to produce the antibody in the living body and collecting a body fluid comprising the antibody from the living body.

4741900

A N T I B O D Y - M E T A L I O N C O M P L E X E S

Vernon Alvarez, John D RodweU, Chyi Lee, John W Goers, Richard Siegel, Thomas McKearn assigned to Cytogen Corporation

This invention relates to antibody-metal ion complexes having a metal ion coordinately bound to a compatible chelator covalently bound to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody-metal ion com- plexes. Therapeutic and in vitro and in vivo dia- gnostic methods utilizing such antibody-metal ion complexes are described.

4741998

M O N O C L O N A L A N T I B O D Y T O MHS-5: A N E W P R O B E F O R

S E X U A L A S S A U L T A N A L Y S E S

John C Herr, Mark Sigman, William M Suther- land assigned to The University of Virginia Alumni Patents Foundation

A new probe for forensic analysis of sexual as- saults is disclosed. The probe is a monoclonal antibody to a new protein marker, MHS-5, in semen. Also disclosed is the hybridoma pro- ducing the antibody as well as an assay utilizing the antibody for forensic analysis of criminal evi- dence.

4742001

M E T H O D O F T E R M I N A T I N G I S O C I T R A T E D E H Y D R O G E N A S E R E A C T I O N I N A N A N A L Y T I C A L

S Y S T E M

Yoji Marui, Takash Nakano, Chozo Hayashi, Tuyosi Fujita, Isamu Takagahara, Ousaka, Japan assigned to Oriental Yeast Co Ltd

Urea, creatinine, creatine, triglycerides, or the like in a specimen can be accurately determined by terminating an isocitrate dehydrogenase reac- tion by addition of ATP and/or a chelating agent in a system wherein N A D + formed from NADH is reproduced into NADH in the con- joint presence of an isocitrate, metallic ions such