PATENT ABSTRACTS

oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromo- some 21.

599

Hybrid, third generation, plasminogen ac- tivators containing plural, heterologous poly- peptide kringles prepared by recombinant DNA techniques as well as the genes coding for the ac- tivators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.

4912207

DNA C L O N E O F H U M A N T H R O M B O M O D U L I N AND

P O R T I O N S T H E R E O F

Philip W Majerus, J Evan Sadler assigned to Washington University

A cDNA having a base sequence for human thrombomodulin has been cloned and charac- terized and the amino acid sequence of the human thrombomodulin has been determined.

4915726

B I O L O G I C A L C O N T R O L OF D O D D E R

Thomas A Bewick, Jana S Stewart, Larry K Bi- nning, Walter R Stevenson assigned to Wisconsin Alumni Research Foundation

A mycoherbicidal inoculum is disclosed for con- trolling the growth of dodder (Cuscuta spp.) on field crops. The inoculum is obtained from spores of Fusarium tricinctum, a species of AI- ternaria, and their mutations.

4916071

P O L Y - K R I N G L E P L A S M I N O G E N A C T I V A T O R

Paul Hung, Narender K Kalyan, Shaw-guang L Lee assigned to American Home Products Cor- poration

~ 1 6 0 7 2

P R O C E S S F O R T H E F O R M A T I O N OF H U M A N - H U M A N

H Y B R I D O M A

Kimiyosh Tsuji, Nobuna Ikewaki, Yokohama, Japan assigned to Idemitsu Kosan Co Ltd

A human-human hybridoma is formed by sub- jecting a transformed human cell to a pro- liferaton inhibitory treatment and then fusing the thus-treated human cell with a human anti- body producing cell. A desired clone may be selected from the resultant fused cells by using an anti-HLA antibody.

4916073

CDNA AND GENE F O R H U M A N A N G I O G E N I N ( A N G I O G E N E S I S FACTOR) AND M E T H O D S O F

E X P R F ~ S I O N

Bert L Vallee, Kotoku Kurachi assigned to Pre- sident and Fellows of Harvard College

DNA sequences encoding a protein having angiogenic activity are disclosed. Expression vectors containing these sequences are in- troduced into host cells and direct the produc- tion of the angiogenic protein. Proteins produced according to the invention are useful in the diagnosis of malignancies, for promoting wound healing, and for other diagnostic and therapeutic purposes.