xxii New Patents

4921856 4921864

DIHYDROPYRIDAZINONE D E R I V A T I V E S , A P R O C E S S F O R

T H E I R P R E P A R A T I O N A N D P H A R M A C E U T I C A L

P R E P A R A T I O N S C O N T A I N I N G T H E S E C O M P O U N D S

4 - P H E N Y L - 4 ( N - ( P H E N Y L ) A M I D O ) P I P E R I D I N E D E R I V A T I V E S A N D

P H A R M A C E U T I C A L C O M P O S I T I O N S A N D M E T H O D

E M P L O Y I N G S U C H C O M P O U N D S

Hdlmut Schickaneder, Peter Morsdorf, Volker Pfahlert, Heidrun Engler, Kurt H Ahrens, Eckental, Federal Republic Of Germany as- signed to Heumann Pharma GmbH & Company

New dihydropryidazinone derivatives cor- responding to the following formula See Patent for Chemical Structure (I) and a process for their preparation and pharmaceutical preparations containing these compounds are described. These compounds are effective positively inotro- pic substances with an improved therapeutic profile.

Linas V Kudzma, H Kenneth Spencer, Sherry A Severnak assigned to BOC Inc

Compounds are disclosed of the formula See Pa- tent for Chemical Structure where R2 is unsub- stituted or substituted phenyl, R3 is lower alkyl, lower cycioalkyl or lower alkoxy lower alkyl, and L is selected from a wide variety of groups. This new class of compounds exhibit improved analgesic and anesthetic properties.

4921871

E N O L A M I D E S , P H A R M A C E U T I C A L

C O M P O S I T I O N S A N D M E T H O D S OF U S E T H E R E O F F O R

T R E A T I N G I N F L A M M A T I O N

4921861

P H A R M A C E U T I C A L C O M P O S I T I O N S

Jozsef Knoll, ne Simonyi Katalin Budai, ne Pol- dermann Edit Berenyi, Ildiko Miklya, Marton Fekete, Gabriella Zsilla, Berta Knoll, Attila Mandi, Lujza Petocz, Istvan Gyertyan, Istvan Gacsalyi, Budapest, Hungary assigned to BASF Aktiengesellschaft

Mary Carethers, Wiaczeslaw Cetenko, David T Connor, Elizabeth Johnson, John S Kiely, Char- les Schwender, Jagadish C Sircar, Roderick Sorenson, Paul C Unangst, Robert F Bruns as- signed to Warner-Lambert Company

The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treat- ment of diseases in which products of lipoxy- genase enzyme activity or the action of leukotrienes contribute to the pathological con- dition.

The 3-amino-4-ethylthio-quinoline of the For- mula I See Patent for Chemical Structure (I) and pharmaceutically acceptable acid addition salts thereof possess useful therapeutical properties. They exhibit a potent and highly selective anx- iolytic and narcosis potentiating effect and are devoid of sedative and anti-convulsive effect. Consequently, the invention relates to pharma- ceutical compositions comprising the compound of Formula I or a salt thereof as active agent. The invention also relates to a new and improved process for the preparation of the compound of Formula I.

4921887

T H I A Z O L E C O M P O U N D S A N D P H A R M A C E U T I C A L

C O M P O S I T I O N C O M P R I S I N G T H E S A M E

Masaaki Matsuo, Takashi Manabe, Shinj Shigenaga, Hiroshi Matsuda, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Company Ltd