ii New Patents

Disclosed is a compound represented by For- mula (I): See Patent for Chemical Structure wherein Arl, Ar2, n, A, B and Z are as defined in claims. Disclosed are also a process for pre- paring the compound and pharmaceutical com- positions containing the compound. The compound has an antihistamic and antiallergic effect.

4931285

A Q U E O U S B A S E D P H A R M A C E U T I C A L C O A T I N G C O M P O S I T I O N F O R D O S A G E

F O R M S

The present invention relates to 8-azaxan derivatives having antiasthmatic activity a~ general formula: See Patent for Chemical ture (II) wherein: R1 is a hydrogen or a alkyl of from one to six carbon atoms arylalkyl group; R2 is a lower alkyl of fro~ to six carbon atoms or an aryl or an ar 3 group; n=f rom 1 to 3 See Patent for Ch~ Structure wherein: R3 and R4 are lower al one to four carbon atoms or complete toge five or six member heterocycle; and where substitution in the triazole ring concerns th~ 8- or 9- positions: their salts which are iologically acceptable, their pharmace compositions and the process for pre t them.

David E Edgren, Felix Theeuwes assigned to ALZA Corporation

A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a sub- coat and an overcoat thermally annealed to pro- vide a single unit coat around the drug.

4931436

C O N D E N S E D D I A Z E P I N O N E S , P R O C E S S E S F O R P R E P A R I N G

T H E M A N D P H A R M A C E U T I C A L C O M P O S I T I O N S C O N T A I N I N G

T H E S E C O M P O U N D S

Wolfhard Engel, Gunte Trummlitz, Wolfgan Eberlein, Gerhard Mihm, Norbert Mayer, Adriaan De Jonge, Klaus Rudolf, Biberach, Federal Republic Of Germany assigned to Dr Karl Thomae GmbH

New condensed diazepinones of general formula I are described See Patent for Chemical Structure (I) wherein B represents one of the divalent groups See Patent for Chemical Structure See Patent for Tabular Presentation and X1, X2, A, RI to RI0 and Z are defined as in the specifica- tion.

4931437

8 - A Z A X A N T H I N E D E R I V A T I V E S , A N D P H A R M A C E U T I C A L

C O M P O S I T I O N S C O N T A I N I N G T H E M

Mauro Fedi, Carl Bacciarelli, Grazian Bonac- chi, Sesto Fiorentino, Italy assigned to Malesci Istituto Farmacobiologico S p A

4931443

PIPERAZINE COMPOUND A] PHARMACEUTICAL USE

THEREOF

Toru Nakao, Kenji Morita, Minoru £ Yasut Morimoto, Nakatsu, Japan assign Yoshitomi Pharmaceutical Industries Ltd

A piperazine compound represented b: general formula: See Patent for Chemical ; ture (wherein each of the symbols is as d~ above) or a pharmaceutically acceptable ac: dition salt thereof, and pharmaceutical thereof as well as intermediates thereof ar closed. The above piperazine compounds ess antipsychotic activities with less ac reaction on the extrapyramidal system an useful as drugs.

4931453

D I P H E N Y L P Y R I D A Z I N E C O M P O U N D S , P R O C E S S E S F,

T H E P R E P A R A T I O N T H E R E ( A N D P H A R M A C E U T I C A L

C O M P O S I T I O N S C O M P R I S I 1 ~ T H E S A M E

Hisash Takasugi, Atsushi Kuno, Hiro Sakai, Yoshie Sugiyama, Takao Takaya, O Japan assigned to Fujisawa Pharmacel Company Ltd

The invention relates to diphenylpyrid compounds useful in the treatmen! cerebrovascular disease, of the formula: Se tent for Chemical Structure wherein 1~ piperazinyl(lower)alkyl, carbamoyl substi