ii New Patents

4946852

4(R)-SUBSTITUTED 6(S)- PHENOXYMETHYL-, 6(S)-

BETA-PHENYLETHYL- AND 6(S)- BETA-STYRYL

TETRAHYDROPYRAN 2 ONES, A HIGHLY STEREOSELECTIVE

PROCESS FOR THEIR PREPARATION,

PHARMACEUTICAL PRODUCTS BASED ON THESE COMPOUNDS,

AND THEIR USE

Heiner Jendralla, Gerhard Beck, Gunther Wess, Bela Kerekjarto, Kelkheim, Federal Republic Of Germany assigned to Hoechst Aktiengesel- lschaft

4(R)-Substituted 6(S)-phenyloxymethyl-, 6(S)- beta-phenylethyl- and 6(S)- beta styryl tetrahydropyran-2-ones of the general formula V See Patent for Chemical Structure V in which R7, R8 and A have the meanings given, and the corresponding open-chain hydroxycarboxylic acids, pharmacologically acceptable salts and esters thereof, processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. Novel alpha, beta-unsaturated lactones for the pre- paration of the compounds of the formula V are also described.

4946861

1,3-DITHIAN-2-YLIDENES, THEIR OXIDES, PHARMACEUTICAL

COMPOSITIONS, AND METHODS OF USE THEREOF

Andre J Weith, Philippe Narld, Signy, Switzer- land assigned to Zyma SA

diseases and vascular diseases pharmaceutical preparations containing compounds of the for- mula I and novel compounds of the formula I. The compounds have liver-protecting and immunomodulating properties.

4946869

AVAROL, PROCESS FOR ITS PRODUCTION,

PHARMACEUTICAL COMPOSITIONS THEREOF, AND ANTIVIRAL USE OF THE SAME

Werner E G Muller, Rudolf K Zahn, Eckart Eich, Wiesbaden Biebrich, Federal Republic Of Germany assigned to Merz and Co GmbH & C o

The antiviral compond avarol, a process for its production, pharmaceutical compositions con- taining said compound, and a method of com- bating viruses therewith, are disclosed.

4946870

DELIVERY SYSTEMS FOR PHARMACEUTICAL OR

THERAPEUTIC ACTIVES

Emmett Partain, George Brode assigned to Union Carbide Chemicals and Plastics Com- pany Inc

Delivery systems containing at least one amino- polysaccharide derivative are provided for the delivery of pharmaceutical or therapeutic actives to a desired topical or mucous membrane site in a subject, and wherein upon delivery, the systems provides a biocompatible, substantive, gas per- meable, film from which actives are available at the designated site.

The invention relates to the use of ketenethioacetals of the formula See Patent for Chemical Structure (I) in which RI represents aryl or heteroaryl, R2 represents hydrogen, an optionally substituted hydrocarbon radical, heteroaryl, an acyi radical, a group of the for- mula -S(O)m-Ra, wherein m is 0, I or 2 and Ra is an optionally substituted hydrocarbon radical; or optionally functionally modified sulpho, A represents an optionally substituted bivalent aliphatic hydrocarbon radical and n is 0 or 1, and pharmaceutically acceptable salts of such com- pounds that contains a salt-forming group, for the treatment of liver diseases, respiratory tract

4946954

PLATINUM PHARMACEUTICAL AGENTS

Abdolhossen Talebian, Dianna C Green, Philip S Schein assigned to Georgetown University

Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the for- mula See Patent for Chemical Structure (I)