166 PATENT ABSTRACTS

formation. The resultant cotton tissues are sub- jected to a selection agent or agents to screen for transformants. The transformed cultures are then induced to commence somatic em- bryogenesis. One possible regime for regenerating such somatic embryos into whole cotton plants is disclosed.

5164181

ENZYME CASTRATION OF ANIMALS

Jule Silver, Robert E Hopkins assigned to Robert E Hopkins II D V M Inc

Male animals may be chemically castrated by in- jecting both testes and/or both spermatic cords with a castratingly effective amount of a pro- tease enzyme such as a chymopapain-rich enzyme preparation.

5154921

PROMOTION OF MATURATION OF HEMATOPOIETIC PROGENITOR CELLS

Ruth Sager, Douglas Trask, Phong Le assigned to Dana-Farber Cancer Institute Inc

A method for promoting maturation of a hematopoietic precursor cell of an animal, which method includes the step of contacting the cell with a maturation-promoting amount of GRO, a polypeptide growth factor.

5154924

TRANSFERRIN RECEPTOR SPECIFIC ANTIBODY -

NEUROPHARMACEUTICAL AGENT CONJUGATES

Phillip Friden assigned to Alkermes Inc

The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain ofa host. The method comprises administering to the host a therapeutically effective amount of an antibody- neuropharmaceutical agent conjugate wherein the antibody is reactive with a transferrin recep- tor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transfertin receptor linked to a

neuropharmaceutical agent and method for treating hosts afflicted with a disease associated with a neurological disorder.

5155036

SERUM-FREE MEDIUM CONTAINING RETINOIC ACID

USEFUL FOR CULTIVATING HUMAN/HUMAN HYBRIDOMAS

Hideaki Hagiwara, Masafumi Naito, Hideo Yuasa, Kasai, Japan assigned to Yoshihide Hagiwara; Hideaki Hagiwa

A serum-free medium for cultivating a human monoclonal antibody-producing human/human hybridoma, said medium comprising a serum- free complete medium and at least IO-12 M but not more than 10-6 M of retinoic acid or its salt.

5155097

POLYCYCLIC ETHER ANTIBIOTIC HAVING

ANTHELMINTIC, ANTICOCCIDIAL AND GROWTH

PROMOTANT ACTIVITY

Walter P Cullen, John Dirlam, Hirosh Maeda, Junsuke Tone assigned to Pfizer Inc

An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel micro- organism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, as a growth promotant in cattle and swine, and as an anthelmintic in mammals, par- ticularly in dogs, cats, sheep, cattle and swine.

5155210

METHODS OF CONJUGATING ACTINOMYCIN D

Wolfgang A Wrasidlo assigned to Brunswick Corporation

The invention provides for antinomycin D derivatives and methods of producing anti- nomycin D derivatives. Such derivatives include isocyanate, thioisocyanate, carboxylic acid, bromide, aldehyde and sulfonic acid derivatives.