PatentALERT

5478821

V

5482924

METHOD OF ACCELERATING THE PROLIFERATION OF EMDOTHELIAL

CELLS WITH INHIBITION OF NO SYNTHASES

Bloy Christia; Cazenave Jean-Pierre; Hercelin Bernard; Teisseire Bernard Paris, FRANCE assigned to Roussel UCLAF

A method of accelerating the proliferation of endothelial cells with inhibition of NO synthases in warm-blooded animals comprising administering to warm-blooded animals an amount of at least one compound selected from the group consisting of a beta-naphthoquinone of the formula (*See Patent for Chemical Structure*) I wherein R is selected from the group consisting of -NH-CO-NH2, -NH-CO-CH3 and -OH and their non-toxic, pharmaceutically acceptable acid addition salts in an amount sufficient to accelerate the proliferation of endothelial cells.

5480827

USE OF POROUS POLYCRYSTALLINE ARAGONITE AS

A SUPPORT MATERIAL FOR IN VITRO CULTURE OF CELLS

Guillemin Genevigrae v; Christel Pascal; Patat Jean-Louis; Meunier Alain Paris, FRANCE assigned to Inoteb

PCT No. PCTiFR92/00707 Sec. 37 1 Date May 3, 1993 Sec. 102(e) Date May 3, 1993 PCT Filed Jul. 20, 1992 PCT Pub. No. WO93/0218 1 PCT Pub. Date Feb. 4, 1993. A three-dimensional solid support for the in vitro cultivation of cells consists essentially of porous polycrystalline aragonite in the form of a cylinder, sphere or plate. The support may be used to successively grow layers of different cells on the support, and is particularly useful for cultivating endothelial cells, fibroblasts and bone marrow cells.

PROTEINACEOUS COMPOSITIONS HAVING AN ACTIVITY ON

ERYTHROPOIESIS

Royet Julien; Amaud Sylvie; Mouchiroud Gu; Blanchet Jean Caluire, FRANCE assigned to Centre National de La Recherche

The invention relates to proteinaceous compositions capable of modulating the development of erythroid progenitors such as obtainable from a biological material selected from bone marrow culture supematants, or kidney cell lysates by contacting said biological material with a specific ligand for the proteinaceous compositions, desorbing said proteinaceous compositions and recovering same by elution. Said compositions are useful in therapeutics.

5486359

HUMAN MESENCHYMAL STEM CELLS

Caplan Arnold I; Haynesworth Stephen E Cleveland Heights, OH, UNITED STATES assigned to Osiris Therapeutics Inc

Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or hMSCs ), and characterization of and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecitic antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.