56 56 highlights...2 2 emeritus professor ang how ghee emeritus professor huang hsing hua emeritus...

5757

Faculty Research

Highlights

2006

11

CORE FACULTY MEMBERSAssoc Professor Ang

Siau

GekAsst Professor Ryan PA BettensInstructor Dr Chanbasha

BasheerProfessor Chan Sze

On HardyAsst Professor Chen Ping

(joint with Physics)Assoc Professor Chin Wee ShongAssoc Professor Chuah

Gaik

KhuanAsst Professor Fan Wai

YipSnr

Research Fellow Dr Goh

Lai YoongProfessor Goh

Suat

HongAssoc Professor Leslie J Harrison Professor Hor

Tzi

Sum Andy (Head)Research Fellow Dr Huynh Han VinhAsst Professor Huang DejianAssoc Professor Stephan JaenickeAssoc Professor Kang Hway

ChuanAssoc Professor Stephan KasapisAssoc Professor Khoo

Soo

BengAssoc Professor Khor

EugeneAssoc Professor Lai Yee HingAsst Professor Lam YulinAsst Professor Martin J LearLecturer Dr Adrian M LeeProfessor Lee Hian

Kee

(Dy

Head)Lecturer Dr Leong

Lai PengAssoc Professor Leong

Weng

KeeProfessor Li Fong Yau

SamAssoc Professor Li TianhuAsst Professor Liu XiaogangAssoc Professor Loh Kian Ping (Dy

Head)Asst Professor Lu YixinLecturer Dr Mak

Ka Wai

KarenResearch Fellow Dr Maung

Maung

Saw

(joint with Diagnostic Radiology, Medicine)Asst Professor David G PopovichLecturer Dr Ship Chee

PingAsst Professor Sim

Wee Sun

Asst Professor Tan Choon

HongAsst Professor Toh

Chee

SengAssoc Professor Valiyaveettil

SureshAssoc Professor Jagadese

J VittalResearch Fellow Dr Weng

ZhiqiangAsst Professor Thorsten

WohlandAssoc Professor Wong Ming Wah

Richard

(Dy

Head)Professor

Xu

Guo

QinAsst Professor Xu

Qing‐HuaAsst Professor Xue

FengAssoc Professor Yao Shao Qin (Asst Head)

(joint with Biological Sciences) Assoc Professor Yip Hon Kay John

(Asst Head)Asst Professor Zeng

HuaqiangResearch Fellow Dr Zhao JinAssoc Professor Zhou Weibiao

22

Emeritus Professor Ang

How GheeEmeritus Professor Huang Hsing

HuaEmeritus Professor Kiang Ai Kim

Adjunct Professor Bosco

Bloodworth

(Health Sciences Authority)Adjunct Assoc Professor Anthony D Buss (Merlion

Pharmaceuticals)Adjunct Asst Professor Mark S Butler (Merlion

Pharmaceuticals)Adjunct Asst Professor Chan Ping Kwong

Peter (Polymer Coating Technologies)Adjunct Asst Professor Thomas Keller (Novartis

Institute of Tropical Diseases)Adjunct Research Fellow Dr Koh

Lip LinAdjunct Assoc Professor Lan

Weiguang

(Sinomem Technology Ltd) Adjunct Assoc Professor Joseph I Rasiah

(PerkinElmer Singapore)Adjunct Assoc Professor Sun Tak

On Eric (S*Bio)Adjunct Asst Professor Andrew Wan (Institute of Bioengineering and Nanotechnology)

Visiting

Professor Bahruddin

bin Saad

(Universiti

Sain

Malaysia)Visiting

Professor Chang Young Tae (New York University) Visiting

Professor Stuart Edelstein (University of Geneva) Visiting

Professor Franz Ekkehardt

Hahn (Westfalische

Wilhelms‐Universitat

Munster)Visiting Professor Robert Huber (Max‐Planck‐Institut

fh

r Biochemie) Visiting

Professor Lang Jianping

(Suzhou

University)Visiting

Professor Liu Ru‐Shi (National Taiwan University)Visiting

Professor Yoshio Ono (Tokyo Institute of Technology)Visiting

Fellow Dr Taewee

Tongdang

(Songkhla

University) Visiting

Professor Teoh

Siang

Guan (Universiti

Sains

Malaysia)Visiting

Senior Fellow Dr Christofora

Hanny

Wijaya

(Bogor

Agriculture University)Visiting

Fellow Dr Yu Long (Nanjing

University of Technology)

EMERITUS FACULTY

ADJUNCT FACULTY

VISITING FACULTY

33

Assoc Professor ANG Siau

GekPh.D., Cambridge Univ., 1987; M.Sc., National Univ. of Singapore, 1984;

B.Sc., National Univ. of Singapore, 1981

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/angsg.htm

Email: [email protected]

MAJOR RECOGNITION•

Chevalier in the Order of the Palmes

Academiques, French Ministry of Youth, Education and

Research, 2004

RESEARCH INTERESTSWe

study

structures

of

organic

and

organometallic

compounds

using

a

variety

of

spectroscopic

techniques

and

other

physical

techniques

including

X‐ray

diffraction

methods.

Specific

focuses

are:• Osmium and ruthenium cluster compounds containing Group 15 ligands• Fabrication of Organometallic

Nanostructures

RECENT HIGHLIGHTReference: Acta

Crystallographica, E62, m1329‐m1331 (2006)

The

title

compound,

[Os(C12

F10

N3

)2

(CO)3

has

been

synthesized

by

the

reaction

of

C6

F5

N=NNHC6

F5

with

H2

(Os)3

(CO)10

. The

OsC3

N3

coordination

is

octahedral

around the

Os

center. Two

bonding

modes,

chelating and

monodentate, are observed for the triazenyl

groups.

PREMIUM PUBLICATIONS•

B‐W Sun, M‐S Zhang, G‐Y Yang, SG Ang

and HG Ang, Decacarbonyl‐1κ3C,2κ3C,3κ4

C‐(μ‐pentafluorophenylhydrazine‐

1κN:2κN’)‐triangulo‐triosmium: a hydrazine‐edge‐bridged triangular triosmium

cluster, Acta

Crystallographica,

E61,

m2419‐m2420 (2005) •

HG

Huang,

CL

Xiang,

YS

Ning,

JY

Huang,

SG

Ang

and

GQ

Xu,

Dry

Synthesis

of

Triple

Cumulative

Double

Bonds

(C=C=C=N) on Si(111)‐7x7 Surfaces, Journal of Physical Chemistry B, 109(41), 19296‐19300 (2005) •

SG

Ang

and

B‐W

Sun,

Crystal

Structure

and

Characterization

of

Organic‐Inorganic

Hybridized

Molecules

with

Molecular Zipper Structures and Two‐Dimensional Grid Networks, Crystal Growth & Design, 5, 383‐386 (2005) •

SG

Ang,

B‐W

Sun

and

S

Gao, Synthesis,

crystal

structures

and

magnetic

properties

of

one‐

and

two‐dimensional

copper (II) complexes bridged by succinate, Inorganica

Chemistry Communications, 7, 795‐798 (2004) •

G‐Y Yang, S‐G Ang, LL Chng, YW Lee, EW‐P Lau, KS Lai and H‐G Ang, Synthesis and Nonlinear Optical Absorption

of Novel Porphyrin‐Osmium‐Cluster Complexes, Chem. Eur. J., 9(4), 900‐904 (2003)

44

Dr CHANBASHA BasheerPh.D., National Univ. of Singapore, 2005; B.Sc., Madras Univ. (India)

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/cb.htm


RESEARCH INTERESTSMy

research

area

is

in

analytical

chemistry,

novel

materials

and

Lab‐on‐a‐Chip‐based

reaction

engineering.

Developing

simple

and

more

efficient

micro

analytical

procedures

for

environmental and biomedical applications. Specific focuses are:• Analytical Chemistry/Environmental Chemistry • Novel materials/Reaction Engineering in Microfluidics


C Basheer,

AA Alnedhary, BSM Rao, S Valiyaveettil

and HK Lee, Development and application of porous membrane‐

protected

carbon

nanotube

micro‐solid‐phase

extraction

(μ‐SPE)

combined

with

gas

chromatography/mass

spectrometry, Anal. Chem., 78, 2853‐2858 (2006)•

C Basheer,

M Vetrichelvan,

S Valiyaveettil

and HK Lee,

Ionic‐liquid supported oxidation reactions

in a silicon‐based

microreactor, Tetrahderon. Lett., 47, 957‐961 (2006) •

C Basheer, H Wang, A Jayaraman, S Valiyaveettil

and HK Lee, Polymer‐coated hollow fiber microextraction

combined

with on‐column stacking in capillary electrophoresis, J Chromatogr. A., 1128, 267‐272 (2006) •

HSN Lee, C

Basheer

and HK Lee,

Determination of

trace

level

chemical

warfare

agents

in

water

and

slurry

samples

using

hollow

fibre‐protected

liquid‐phase

microextraction

followed

by

gas

chromatography–mass

spectrometry,

J.

Chromatogr. A. 1124, 91‐96 (2006) •

C

Basheer,

S

Sindhu,

S

Valiyaveettil

and

HK

Lee,

Development

and

application

of

simple

capillary‐microreactor

for

the heterogonous catalysis of glucose using porous gold (0) catalyst, Chem. Commun., 3, 409‐410 (2005)

55

Asst Professor Ryan P A BETTENSPostdoc., Australian National Univ., 1999; Postdoc., Ohio State Univ., 1996;

Postdoc., ETH, Zurich, 1994; Ph.D., Monash

Univ., 1992; B.Sc., Univ. of

Queensland, 1986

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/bettens.htm


RESEARCH INTERESTSMy research area is in the understanding and describing accurately via computational chemistry

inter‐

and

intra‐molecular

interactions. Ultimately

the

understanding

and

description

will

be

applied to the dynamics of large systems like proteins and nucleic acids. Specific focuses are:• Accurately describe and predict enzyme‐substrate interactions• Reproduce and predict accurate nmr

spectra of proteins and other large molecules


Y Fan, J Ho and RPA Bettens, Approximating coupled cluster level vibrational

frequencies with composite methods, J.

Phys. Chem. A, 110, 2796‐2800 (2006) •

RPA

Bettens,

Comparison

of

fundamental

and

harmonic

frequencies

of

first‐row

closed‐shell

diatomics,

J. Phys. Chem. A, 108, 1826‐1829 (2004) •

RPA

Bettens,

Bound

state

potential

energy

surface

construction:

Ab

initio

zero‐point

energies

and

vibrationally

averaged rotational constants, J. Am. Chem. Soc., 125, 584‐587 (2003) •

I

Medvedev,

M

Winnewisser,

FC

De

lucia,

E

Herbst,

E

Yi,

LP

Leong,

RPA

Bettens,

E

Biankowska‐jaworska,

O

Desyatnyk,

L

Pszczonkowski

and

Z

Kisiel,

The

millimeter‐

and

submillimeter‐wave

spectrum

of

the

trans‐trans

conformer of diethyl ether, Astrophysical J. Supp., 148, 593‐597 (2003) •

FL Bettens, RPA Bettens, RD Brown and PD Godfrey, The microwave spectrum, structure, and ring‐puckering of

the

cyclic dipeptide

diketopiperazine, J. Am. Chem. Soc., 122, 5856‐5860 (2000)

RECENT HIGHLIGHTReference: J. Phys. Chem. A, 110, 8777‐8785 (2006)

A

“black‐box”

method

for

fragmenting

molecules

as

large

as

proteins

into

a

significant

number

of

smaller

fragment

molecules

that

are

more

amenable

to

high‐

level

quantum

chemical

calculations

was

presented.

By

taking

an

appropriate

linear

combination

of

the

fragment energies, it is shown that it is possible in many

cases

to

obtain

highly

accurate

total

energies

when

compared to the total energy of the full molecule.

66

Professor CHAN Sze

On HardyPh.D., Univ. of Manchester Institute of Science & Technology, 1975; B.Sc.,

Southbank

Polytechnic, 1972

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chanhardy.htm



specific focuses are:• Functional polymers• Nanomaterials

RECENT HIGHLIGHTReference: J. Materials Chemistry, 15, 4161‐4166 (2005)

Y‐junction

polyaniline

(PANI)

nanorods

and

nanotubes

(40‐100

nm

in

diameter

and

a

few

micrometers

in

length)

were

prepared,

for

the

first

time,

using

self‐assembled

magnetic

nanoparticles

as

templates

and

pH

control

in

an

aqueous

medium.

The

morphologies

of

PANI

nanostructures (rods and tubes) were confirmed by TEM and the effect of reaction conditions on

the morphologies of PANI nanostructures was also studied.


PKH Ho, BGT Tan, KL Tan, SC Ng and HSO Chan, Journal of the American Chemical Society, 117, 8517‐8523 (1995)•

HSO Chan and SC Ng, Progress in Polymer Science, 23, 1167‐1231 (1998)•

SC Ng, HF Lu and Chan HSO, Advanced Materials, 12, 1311‐1315 (2000)•

DM Cheng, HB Xia

and HSO Chan, Journal of Nanoscience

and Nanotechnology, 5, 466‐472 (2005)•

HB Xia, C Xiao and HSO Chan, Nanotechnology, 15, 1807‐1811 (2004)

77

Asst Professor CHEN PingPh.D., Xiamen

Univ., 1997; M.Sc., Xiamen

Univ., 1994; B.Sc., Xiamen

Univ.,

1991

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chenp.htm



specific focuses are:• Solid‐state Hydrogen Storage Materials • Synthesis and Characterization of ternary and multinary

nitrides, imides and amides • Heterogeneous catalysis

RECENT HIGHLIGHTOn‐board

hydrogen

storage

is

one

of

the

biggest

technical

challenges

in

the

global

energy

transition from fossil fuel to hydrogen energy. Novel Metal‐N‐H system has been developed for

hydrogen storage in the team since 2001. Reversible H2

storage over Li‐N‐H, Li‐Mg‐N‐H and Li‐

Ca‐N‐H systems has been demonstrated.


P

Chen,

ZT

Xiong,

LF

Yang,

GT

Wu

and

WF

Luo,

Mechanistic

Investigations

on

the

Heterogeneous

Solid‐State

Reaction of Magnesium Amides and Lithium Hydrides, J. Phys. Chem. B, published online (2006)•

JJ Hu, GT Wu, YF Liu, ZT Xinog, P Chen, K Murata, K Sakata and G Wolf, Hydrogen

Release from

Mg(NH2

)2

‐MgH2

through Mechanochemical

Reaction. J. Phys. Chem. B, published online (2006)•

ZT

Xiong,

GT

Wu,

JJ

Hu

and

P

Chen,

Thermodynamic

and

kinetic

investigations

of

the

hydrogen

storage

in

the

Li‐

Mg‐N‐H system, J. Alloys Compd, 398, 235‐239 (2005)•

ZT Xiong, GT Wu, JJ Hu

and P Chen, Ternary imides for hydrogen storage. Adv. Mater., 16, 1522‐1524 (2004)•

P

Chen,

ZT

Xiong,

JZ

Luo,

JY

Lin

and

KL

Tan,

Interaction

between

Lithium

Amide

and

Lithium

Hydride.

J.

Phys.

Chem. Â B,

107, 10967‐10970 (2003)

88

Assoc Professor CHIN Wee ShongPostdoc., Univ. of Bristol, 1994; Ph.D., National Univ. of Singapore, 1993;

B.Sc., National Univ. of Singapore, 1987

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chinws.htm


RESEARCH INTERESTSOur

research

focus

on

the

field

of

nanostructures

and

their

assemblies.

The

targets

include

finding

new

ways

to

synthesize

size‐

and

shape‐controllable

nanocrystals,

understanding

their

interactions and properties, and developing methods to assemble them into novel nanostructures.

Specific focuses are:• Nanostructural

materials and their assembly • Surface and spectroscopy

RECENT HIGHLIGHTReference: Angew. Chem. Int. Edn, 43, 5685 (2004)

An

unprecedented

preparation

of

Ag2

S

nanocrystals,

with

predictable

sizes

and

shapes,

using

chemical

method

starting

from

an

easily

prepared

silver

precursor

is

reported.

Through

a

careful

tuning

of

several

critical

thermodynamic

and

kinetic

parameters,

well‐defined

shapes

of

Ag2

S

nanocrystals,

from

nanocubes,

faceted

or

spherical nanocrystals,

to nanorods,

can

be

readily

produced.


WP

Lim,

Z

Zhang,

HY

Low and

WS

Chin, A

Neat

Preparation

of

Ag2S

nanocrystals

with

Predictable

Shapes

and

Sizes, Angew. Chem. Int. Edn, 43, 5685 (2004) •

WP Lim, HY Low and WS Chin, IR‐luminescent PbS‐polystyrene Nanocomposites

Prepared from

Random

Ionomers

in Solution, J. Phys. Chem. B,

108, 13093 (2004) •

TP Ang, TSA Wee and WS Chin, Three‐dimensional self‐assembled monolayer (3D SAM) of n‐alkanethiols

on copper

nanoclusters,

J. Phys. Chem. B,

108, 11001 (2004) •

TP Ang

and WS Chin, Dodecanethiol‐protected Copper/Silver Bimetallic Nanoclusters

and Their Surface Properties, J.

Phys. Chem. B,

109, 22228

(2005) •

Z

Zhang,

SH

Lee,

JJ

Vittal

and

WS

Chin,

A

Simple

Way

To

Prepare

PbS

Nanocrystals

with

Morphology

Tuning

at

Room Temperature,

J. Phys. Chem. B, 110, 6649‐6654 (2006)

99

Assoc Professor CHUAH Gaik

KhuanPostdoc., Fritz‐Haber‐Instituet, Berlin , 1987; Ph.D., Texas A&M Univ., 1987;

B.Sc., Univ. of Singapore, 1984

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/chuahgk.htm



study

the

synthesis

of

useful

materials

for

catalysis

including

modification

of

textural

properties

such

as

surface

area,

porosity,

thermal

stability

and

introduction

of

dopants

for

specific functionalities . Specific focuses are:• Synthesis of micro‐mesoporous

materials for catalysis • Catalysis in fine chemicals synthesis and renewables

RECENT HIGHLIGHTReference: Curr. Org. Chem., 10(13), 1639‐1654 (2006)

The

Meerwein‐Ponndorf‐Verley

(MPV)

transfer

hydrogenation

of

aldehydes

and

ketones

to

the

corresponding alcohols is distinguished by its exceptional chemoselectivity.

The

article

provides

a critical review of the recent literature on heterogeneous catalysts for the MPV reaction.


GK

Chuah,

S

Jaenicke,

YZ

Zhu

and

SH

Liu,

Meerwein‐Ponndorf‐Verley

Reduction

over

Heterogeneous

Catalysts,

Curr. Org. Chem., 10(13), 1639‐1654 (2006)•

YT Nie, GK Chuah, and S Jaenicke, Domino‐cyclisation

and hydrogenation of citronellal to menthol over bifunctional

Ni/Zr‐Beta and Zr‐beta/Ni‐MCM‐41 catalysts, Chem. Commun., 790 –

792 (2006)•

SA Bagshaw, NI Baxter, DRM Brew, CF Hosie, YT Nie, S Jaenicke

and GK Chuah, Highly ordered mesoporous

MSU‐

SBEA

/zeolite

Beta composite material, J. Mater. Chem.

16, 2235 – 2244 (2006) •

YZ Zhu, GK Chuah

and S Jaenicke, Selective Meerwein‐Ponndorf‐Verley, Reduction of α,β‐Unsaturated Aldehydes

over Zr‐Zeolite

Beta, J. Catal., 241, 25‐33 (2006) •

YZ Zhu, KL Foo, GK Chuah

and S Jaenicke, Dynamic Kinetic Resolution of Secondary Alcohols Combining Enyzme‐

Catalyzed Transesterification

and Zeolite‐Catalyzed Racemization, Chem. Eur. J., in press

M

O

CH

R2

R1

R3 R4

C

M

O O

C

R4R3

C

HR2

R1

M

O O

C

R4R3

C

R2

R1H

1010

Asst Professor FAN Wai

YipPostdoc., Univ. of California Berkeley, 2000; Ph.D., Univ. of Cambridge, 1998;

M.Sc., Univ. of Toronto, 1996; B.Sc., Univ. of London, 1994

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/fanwy.htm



research

area

is

in

the

spectroscopy

and

photochemistry

of

reactive

intermediates

are

explored in systems ranging from atmospheric chemistry, organometallic

homogeneous catalysis

to nanomaterial

formation mechanism . Specific focuses are:• Reactive intermediate chemistry in homogeneous catalysis and gas phase systems • Light‐induced nanochemistry


H Tan, SP Li and WY Fan, Core-shell and hollow nanocrystal

formation via small molecule surface photodissociation;

Ag@Ag2

Se as an example, J Phys Chem B, 110, 15812-15816 (2006) •

TS Chong,, S T Tan and W Y Fan, FTIR Studies of Iron Carbonyl Intermediates in Allylic

Alcohol Photoisomerization,

Chem. Eur

J, 12, 5128-5133 (2006) •

Tan, H, E YE and W Y Fan, Alumina-template synthesis of fluorescent RuO2

nanotubes

derived from Ru3

(CO)12

cluster.

Adv Materials, 18, 619-623 (2006) •

YE, E, H Tan, S P Li and W Y Fan, Self-Organization of Core-shell Palladium Spherical Aggregates induced by Laser

and Thermal Decomposition of Pd(PPh3

)4

, Angew Chemie, 45, 1120-1123 (2006) •

CH

Ng

and

W

Y

Fan,

Shape

evolution

of

Cu2

O

nanostructures

via

kinetic

and

thermodynamic

controlled

growth,

J

Phys Chem B ASAP article

(2006)

RECENT HIGHLIGHTReference: Chem. Eur

J, 12, 5128-5133 (2006)

Key

intermediates

especially

the

p‐allyl

HFe(CO)3

(C3

H4

OH)

species

in

the

laser‐induced

photoisomerization

of

allylic

alcohols

to

aldehydes

catalyzed

by

Fe3

(CO)12

or

Fe(CO)4

PPh3

have been detected using FTIR absorption spectroscopy. p-allyl

Fe intermediate

1111

Dr GOH Lai YoongD.Sc., Univ. of London, 1997; Ph.D., Univ. of London, 1967; B.Sc., Univ. of

Hong Kong, 1963

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohlyg.htm



Royal Society Commonwealth Developing Countries Fellowship, Royal Society, UK, 1991 •

Grant award from Australian Department of Industry and Technology, Bilateral Science and

Technology Collaboration programme

for work on Manganese Chemistry, Tenable at Monash

University, 1993‐1994

RESEARCH INTERESTSOrganochromium

and organoruthenium

chemistry are among the interests. Specific focuses are:•

Organochromium

chemistry, with special reference to the homolytic

reactivity of CpCr(CO)3

. to a variety of substrates

•

Organoruthenium

chemistry, with special reference to species containing hexamethylbenzene,

Cp/Cp*, indenyl, trispyrazolylborate‐type, and thiolato

ligands

RECENT HIGHLIGHTReference: Chem. Commun.

WEB

(2006)

Reaction

of

1,2,4,6‐thiatriazinyls

(4

and

9)

with [CpCr(CO)3

]2

(3) yielded new complexes

with

either η1, 5,

or η2,

6,

coordination

across

S=N

bonds.

(Scheme

1)

The

novelty

in

these

reactions

is

the

suppression

of

oxidative

addition

by

employment

of

radical

coupling

under mild conditions. This strategy provides

an

alternative

to

the

recently

reported

use

of

β‐pyridyl

groups in the building of multi‐spin

magnetic

complexes

incorporating

C,N,S

radicals.


RYC

Shin,

LY

Goh,

Pentamethylcyclopentadienyl

Ruthenium(III)

vs

Hexamethylbenzene

Ruthenium(II)

in

Sulfur‐

Centered Reactivity of Their Thioether‐Thiolate

and Allied Complexes,

Acc. Chem. Res., 39, 301‐313 (2006)•

LY

Goh, W

Chen

and

RCS

Wong,

Unprecedented

Cage‐Opening

of P4S3

Initiated

by

an

Organometallic

Radical:

Synthesis and Structure of [Cp4

Cr4

(CO)9

(P4

S3

)], Angew Chem., Int. Ed. Engl.,

32, 1728‐1729 (1993) •

LY Goh, Z Weng, WK Leong

and JJ Vittal, Organometallic‐initiated cleavage of the metal chelate

and thiazole

rings in

a cyclopentadienylchromium

Complex, J. Am. Chem. Soc., 124, 8804‐8805 (2002) •

SL

Kuan,

WK

Leong,

LY

Goh

and

RW

Webster,

Redox

Dependent

Isomerization

of

Organometallic

RuII/RuIII

Compounds Containing the Hydrotris(Methimazolyl)Borate

Ligand.

An

Electrochemical

Square

Scheme

Mechanism.

Organometallics,

24, 4639‐4648 (2005) •

HF

Lau,

VWL

Ng,

LL

Koh,

GK

Tan,

LY

Goh,

TL

Roemmele,

SD

Sonja

and

RT

Boeré,

Cyclopentadienylchromium

complexes of 1,2,3,5‐dithiadiazolyls: η2π

complexes of cyclic sulfur‐nitrogen compounds, Angew. Chem. Int. Ed.,

45,

4498‐4501 (2006)

CrOCCOCO

SN

N

NPh

Ph5

CrOC

OC

N

SN

N

CF3

6

CrOC COCO

23

R = Ph (4)

+

R = CF3 (9)

SN

NN

R

Ph2

1212

Professor GOH Suat

HongD.Sc., National Univ. of Singapore, 1993; Ph.D., Univ. of Akron,

1971; M.Sc.,

Univ. of Akron, 1966; B.Sc., Nanyang

Univ., 1964

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/gohsh.htm



National Science Award, National Science and Technology Board, Singapore, 1997 •

Staff Achievement Award, National University of Singapore, 1998 •

Achievement Award, ASEAN Committee of Science and Technology, 1998 •

FACS Citation Award, Federation of Asian Chemical Societies, 2003


interests

lie

on

polymer/materials

science

–

recent

research

focuses

on

the

development

of

high‐performance

polymer‐grafted

carbon

nanotube/polymer

nanocomposites

.

Specific

focuses

are:• Polymer/carbon nanotube

nanocomposites• Double‐C60

‐end‐capped polymeric materials

RECENT HIGHLIGHTReference: Macromolecules, 39, 4932‐4934 (2006)

The

tensile

strength

and

the

toughness

of

poly(n‐

butyl

methacrylate)

are

increased

by

240%

and

190%,

respectively,

upon

end‐capping

with

C60

.

Poly(vinyl

chloride)

is

strengthened

and

toughened by the incorporation of double‐C60

‐end‐

capped poly(n‐butyl methacrylate).


M Wang, KP Pramoda

and SH Goh, Reinforcing and toughening of poly(vinyl

chloride) with double‐C60‐end‐capped

poly(n‐butyl methacrylate), Macromolecules, 39, 4932‐4934 (2006)•

M

Wang,

KP

Pramoda

and

SH

Goh,

Enhancement

of

interfacial

adhesion

and

dynamic

mechanical

properties

of

poly(methyl

methacrylate)/multiwalled

carbon

nanotube

composites

with

amine‐terminated

poly(ethylene

oxide),

Carbon, 44, 613‐617 (2006)•

X

Li,

KL

Liu,

J

Li,

PS

Tan,

LM

Chan,

CT

Lim

and

SH

Goh,

Synthesis,

characterization,

and

morphology

studies

of

biodegradable

amphiphilic

poly[(R)‐3‐hydroxybutyrate]‐alt‐poly(ethylene

glycol)

multiblock

copolymers,

Biomacromolecules, in press•

Y Liu, DC Wu, WD Zhang, X Jiang, CB He, TS Chung, SH Goh

and KW Leong, Polyethylenimine‐grafted multiwalled

carbon

nanotubes

for

secure

noncovalent

immobilization

and

efficient

delivery

of

DNA,

Angewandte

Chemie

International Edition, 44, 4782‐4785 (2005)•

DC Wu, Y Liu, CB He and SH Goh, Blue photoluminescence from hyperbranched

poly(amino

ester)s, Macromolecules

38, 9906‐9909 (2005)

0.0 0.6 1.2 1.80

4

8

12

16

Stre

ss (M

Pa)

Strain (mm/mm)

Stress-strain curves of PBMA (lower curve) and C60

-PBMA-C60

(upper curve)

1313

Assoc Professor Leslie J HARRISONPh.D., Univ. of Glasgow, 1983; B.Sc., Univ. of Glasgow, 1980

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/harrison.htm


RESEARCH INTERESTSMy specific focuses are:• Organic chemistry• Natural products

RECENT HIGHLIGHTWe are interested in the isolation of natural products and determination of their structures using

mainly

1D

and

2D

nuclear

magnetic

resonance

techniques.

At

present,

we

are

concentrating

on

the

constituents

of

three

plant

families,

the

Guttiferae,

the

Hepaticae

and

the

Orchidaceae.

The

compounds obtained are subjected to biological testing.


LHD Nguyen and LJ Harrison, Xanthones

and Triterpenoids

from the Bark of Garcinia

Vilersiana, Phytochemistry, 53,

111‐114 (2000)•

LHD Nguyen and LJ Harrison, Xanthones

and Triterpenoids

from the Bark of Garcinia

Vilersiana,

Phytochemistry, 53,

111‐114 (1999)•

R

Huang,

LJ

Harrison

and

KY

Sim,

A

Triterpenoid

with

a

Novel

Abeo‐dammarane

Skeleton

from

Dysoxylum

cauliflorum, Tetrahedron Lett., 40, 1607‐1610 (1999)•

YW Leong, LJ Harrison and AD Powell, Phenanthrene

and Other Aromatic Compounds from Bulbophyllum

vaginatum,

Phytochemistry,

50, 1237‐1241 (1999)•

YW Leong

and LJ Harrison, (20R,23E)‐Eupha‐8,23‐diene‐3,25‐diol from Tripetalum

cymosum,

Phytochemistry,

50, 849‐

857 (1999)

1414

Professor HOR Tzi

Sum AndyPostdoc., Yale Univ. , 1984; D.Phil., Univ. of Oxford, 1983; B.Sc.(Hons),

Imperial College of Science and Technology, 1979

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/hor.htm



D.Sc., University of London, 1999•

ASEAN Achievement Award (Sciences), ASEAN Business Forum, 1994•

Member, International Advisory Board,

Chemistry: An Asian Journal, VCH/Wiley, 2006‐present•

Member, International Advisory Board, Inorganica

Chimica

Acta

(Elsevier), 2003‐present•

Wilsmour

Fellow, University of Melbourne, 2004•

Inorganic Foundation Professor & Frances Lion Memorial Lecturer,

University of Sydney, 2003•

Anthony Mason Fellow, University of New South Wales, 1999 •

Chair, 9th International Symposium for Chinese Organic Chemists & 6th International

Symposium for Chinese Inorganic Chemists, 2006


use

our

synthetic

organometallic

chemistry

capabilities

to

design

new

catalysts,

functional

materials

and

molecular

imaging

systems.

In

catalysis,

we

focus

on

ethylene

oligomerization,

Suzuki

and

other

C‐C

cross‐coupling

reactions.

Our

materials

research

encompasses

supramolecular

assembly and heteromultinuclear

syntheses. Specific focuses are:• Homogeneous & Environmental Catalysis • Heterometallic

Syntheses & Applications

RECENT HIGHLIGHTReference: Organometallics

, 25, 1199‐1205 (2006)

Under

solventless

conditions,

benzothiazole

reacts

with

benzyl

bromide

to

give

near‐quantitative

yield

of

N‐

benzylbenzothiazolium

bromide

(A),

which

is

a

convenient

air‐stable heterocyclic carbene

precursor. Treatment of A

with

Pd(OAc)2

in

DMSO

gives

an

unprecedented

dinuclear

N,S‐

heterocyclic

carbene

complex,

[PdBr2

(NHC)]2

(illustration)

which is active towards Mizoroki‐Heck coupling reactions.


SH

Chong,

LL

Koh,

W

Henderson

and

TSA

Hor,

Methylation

of

[Pt2

(μ‐SRμ‐SPPh3

)4

]:En

route

to

mixed

thiolato

bridged complexes, Chemistry: An Asian Journal, 1264‐272 (2006) •

Z

Weng,

S

Teo

and

TSA

Hor,

Isolation

and

structural

elucidation

of

a

Ni(0)‐Al(CH3

)3

bimetallic

complex

with

an

agostic

alpha‐C–H in a Bridging Methyl, Chem. Commun., 12,

1319‐1321 (2006)•

SK

Yen,

LL

Koh,

FE

Hahn,

HV

Huynh

and

TSA

Hor,

Convenient

entry

to

mono‐

and

dinuclear

palladium(II)benzothiazolin‐2‐ylidene

complexes

and

their

activities

towards

heck‐coupling,

Organometallics,

25,

5105-5112 (2006) •

Z

Weng,

S

Teo,

LL

Koh

and

TSA

Hor,

Ethylene

oligomerization

of

coordinatively

&

electronically

unsaturated

low‐

valent

nickel,

Angew. Chem. Int. Ed., 44, 7560‐7564 (2005) •

Z

Weng,

S

Teo

and

TSA

Hor,

Singapore

Patent

Application

200604713‐8,

Thermally

stable

chromium(III)

catalysts

supported by tridentate ligands

for ethylene tetramerization

to 1‐octene (2006)

1515

Asst Professor HUANG DejianPostdoc., Massachusetts Inst. Techn.o, 2001; Ph.D., Indiana Univ. Bloomington,

1999; M.Sc., Chinese Acad. of Sciences, 1990; B.Sc., Fujian

Teachers Univ., 1987

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huangdj.htm



research

area

is

in

Naturally

occurring

flavonoids

and

their

metal

complexes

as

enzymatic

antioxidant

(SOD)

mimetics,

sensing

of

reactive

oxygen

species

in

food

and

biological

systems

using

fluorescent

quantum

dots,

antioxidants

in

traditional

Chinese

medicine

(TCM).

Specific

focuses are:• Reactive oxygen species and antioxidants in foods and TCM • Transition metal chemistry and catalysis


KX Hay, VY Waisundara, M Timmins, B Ou, K Papalado, N McHale and D Huang, High-Throughput Quantitation

of

Peroxyl

Radical Scavenging Capacity in Bulk Oils. J.Agri. Food Chem., 54, 5299-5305 (2006)•

D Huang, B Ou

and L Ronald, Prior the Chemistry behind antioxidant assays, J. Agri. Food Chem., 53, 1841‐1856 (2005) •

B

Ou,

D

Huang,

M

Hampsch‐Woodill

and

JA

Flanagan, When

East

Meets

West:

the

relationship

between

yin/yang

and antioxidation/oxidation, FASEB J.

, 7(2), 127‐129 (2003)•

D Huang, KB Renkema

and KG Caulton, Cleavage of F-C(sp2) bonds by MHR(CO) (PtBu2

Me)2

(M = Os and Ru; R = H,

CH3

or Aryl): Product dependence on M and R, Polyhedron, 25, 459-468 (2006)•

D

Huang,

PR

Koren,

K

Folting,

ER

Davidson

and

KG

Caulton,

Facile

and

Reversible

Cleavage

of

C‐F

Bonds.

Contrasting Thermodynamic Selectivity for Ru‐CF2H vs

F‐Os=CFH, J. Am. Chem. Soc., 122(37), 8916‐8931 (2000)

RECENT HIGHLIGHTReference: Analytical Chemistry, 78, 3097-3103 (2006)

A

novel

approach

to

monitoring

of

mainstream

smoke

reactive

oxygen

species

(ROS)

has

been

developed and applied to the quantitation

of

smoke oxidants.

Dihydrorhodamine

6G

(DHR‐6G)

was selected as the molecular probe and the reaction is monitoring in real time using a fiber optic

reflective fluorescent spectrometer.

1616

Dr HUYNH Hanh

VinhPh.D., Univ. Münster

(WWU), Germany, 2002; B.Sc., Univ. Münster

(WWU), Germany, 1999

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/huynh.htm



Feodor

Lynen

Research Fellowship, Alexander von Humboldt Foundation, 2003‐2004

RESEARCH INTERESTSWe study organometallic

chemistry and catalysis. Specific focuses are:•

Synthesis of novel N‐heterocyclic Carbene

(NHC) complexes and their application as catalysts

for organic transformations •

Bioactivities of organometallic

compounds

RECENT HIGHLIGHTReference: Chem. Commun., 3833‐3835 (2006)

The truely

hemilabile

nature of a novel thioether‐functionalized N‐heterocyclic carbene

ligand

is

demonstrated in a range of Pd(II) complexes.


HV Huynh, C Holtgrewe, T Pape, LL Koh

and E Hahn, Organometallics, 25, 245‐249 (2006) •

HV Huynh, TC Neo and GK Tan, Organometallics, 25, 1298‐1302 (2006)•

HV Huynh, N Meier, T Pape and FE Hahn, Organometallics, 25, 3012‐3018 (2006)•

HV Huynh, Y Han, J H H Ho and GK Tan, Organometallics,

25, 3267‐3274 (2006) •

SK Yen, LL Koh, FE Hahn, HV Huynh and TSA Hor, Organometallics, 25, 5105‐5112 (2006)

1717

Assoc Professor Stephan JAENICKEPostdoc., Max Planck Society, 1988; Postdoc., Michigan State University, 1983;

Ph.D., Dr. rer. nat., 1981; B.Sc., Diplomchemiker, 1976

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jaenicke.htm


RESEARCH INTERESTSWe study the heterogeneous catalysis with special emphasis on chiral

synthesis: hydrogenations

on

chirally

modified

solid

surfaces,

homogeneous

catalysts

immobilized

in

supported

ionic

liquids,

immobilized

enzymes,

whole

cell

fermentation

(white

biotechnology).

Specific

focuses

are:• Catalytic hydrogenation and hydroformylation; selective oxidations with molecular oxygen • Micro‐reactor applications in three‐phase flow: mass transport enhancement in Taylor flow

conditions

RECENT HIGHLIGHTReference: Chem. Eur. J. (to be cited as DOI: 10.1002/chem.200600723)

Kinetic

resolution

of

racemic

alcohols

by

enzymatic

transesterification

is

combined

with

racemization

of the off‐enantiomer

over a modified zeolite

catalyst. The bulky esters (octanoates

or

laurates)

formed

in

the

enzymatic

reaction

cannot

access

the

active

site

in

the

zeolite,

where

they could undergo undesired racemization, and are obtained with excellent enantiomeric

excess.


YZ

Zhu,

GK

Chuah

and

S

Jaenicke,

Selective

Meerwein–Ponndorf–Verley

reduction

of α,β‐unsaturated

aldehydes

over Zr‐zeolite

beta, J. Catalysis, 241, 25‐33 (2006)•

S Jaenicke, Characterization of Heterogeneous Catalysts by

Use of

Model

Reactions,

Catalysis

Surveys

from

Asia,

9,

173‐185 (2005)•

N

Qafisheh,

S

Mukhopahdyay,

AV

Joshi,

Y

Sasson,

GK

Chuah

and

S

Jaenicke,

Potassium

Phosphate

as

a

High

Performance Solid Base in Phase Transfer Catalyzed Alkylation

Reactions, Ind. Eng. Chem Res., in press (2006) •

X Wang, JLC Lee, Y Nie

and S Jaenicke, Evaluation of multiphase microreactors

for the direct formation of hydrogen

peroxide,

Applied Catalysis A: General, in press (2006)•

YZ Zhu, KL Foo, GK Chuah

and S Jaenicke, Dynamic Kinetic Resolution of Secondary Alcohols Combining Enyzme‐

Catalyzed Transesterification

and Zeolite‐Catalyzed Racemization, Chem. Eur. J.,

in press (2006)

OH

OO

O

O(R )-1 -phenyle thanol

(S )-1 -phenyle thanol(inside m icrochannels o f zeo lite beta )

Acyl donor

racem iza tion ca talyst

L ipase

1818

Assoc Professor KANG Hway

ChuanPh.D., Caltech, 1989; B.Sc., Yale Univ., 1983

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/kanghc.htm


RESEARCH INTERESTSMy specific

focuses include:• Computational chemistry

RECENT HIGHLIGHTMy research focuses upon the use of simulations grounded in statistical and quantum mechanics

to

provide

molecular

scale ʺpicturesʺ

of

physical

and

chemical

processes

in

molecules,

clusters,

surfaces and bulk materials. We are interested in modelling

the kinetics of catalytic reactions, the

structure

and

properties

of

solid

and

cluster

surfaces,

reaction

energetics,

the

interactions

and

reactions of molecules adsorbed on surfaces, and the energetics

of defects on surfaces and in the

bulk.


HC Kang, Lateral Interactions Between Adsorbed Hydrogen Atoms on the Si(100)‐(2 x 1) Surface, Surf. Sci., 445, 167‐

176 (2000)•

ZH

Loh

and

HC

Kang,

Chemisorption

of

NH3

on

Si(100)‐(2x1):

A

Study

by

First‐Principles

Ab

Initio

and

Density

Functional Theory, J. Chem. Phys., 112, 2444‐2451 (2000)•

C Yang and HC Kang, Geometry of Dimer

Reconstruction on the C(100), Si(100), and Ge(100) Surfaces, J. Chem. Phys.,

110, 11029‐11037 (1999)•

C Yang and HC Kang, Cluster Study of the Dimer

Geometry on the C(100) Surface, Surf. Science,

409, 521 (1998)•

HC

Kang,

Spin

Polarization

and

the

Energetics

of

Chlorine

Adsorption

on

the

GaAs(110),

J.

Chem.

Phys.,

109,

6911‐

6915 (1998)

1919

Assoc Professor Stefan KASAPISPostdoc., Cranfield

Univ., 1993; Ph.D., Cranfield

Univ., 1991; M.Sc., Univ. of

London, 1988; B.Sc., Aristotle Univ., 1986

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/sk.htm



Editor, Food Hydrocolloids, 2006‐present •

Member of the Editorial Board, Carbohydrate Polymerism, 2005‐present •

Organizer, 9th International Hydrocolloids Conference, 2008

RESEARCH INTERESTSGeneral

research

interest

lies

on

Structure‐function

relationships

in

hydrocolloids.

Specific

focuses are:• Gelatin, fat, sugar replacing in food products for improved sensory perception and health • Glass transitions and the kinetics of active compound release in foods and pharmaceuticals

RECENT HIGHLIGHTReference: Biomacromolecules, 7, 1671‐1678 (2006)

The

prevalent

analytical

framework

traditionally

employed

to

follow

the

transition

from

the

rubbery

to

glasslike

consistency

in

biomaterials

is

that

of

the

free

volume

theory

in

conjunction

with the WLF equation. Increasingly, the combined WLF/free volume approach is challenged by

the coupling model which is able to provide additional insights into the physics of intermolecular

interactions in synthetic materials at the vicinity of Tg. The model in the form of the Kohlrausch‐

Williams‐Watts

function

described

well

the

spectral

shape

of

the

local

segmental

motions

of

gelatin/co‐solute

at

Tg.

The

analysis

provided

the

intermolecular

interaction

constant

and

apparent

relaxation

time, parameters which

depend

on

chemical

structure.

Results

appear

to

be

encouraging for further explorations of the dynamics of densely packed biomaterials at the glass

transition region.


S

Kasapis,

Building

on

the

WLF

/

free

volume

framework:

Utilisation

of

the

coupling

model

in

the

relaxation

dynamics of the gelatin / co‐solute system, Biomacromolecules, 7, 1671‐1678 (2006) •

SL Tay, S Kasapis, CO Perera

and PJ Barlow, Functional and structural properties of 2S soy protein in relation to other

molecular protein fractions, Journal of Agricultural and Food Chemistry, 54, 6046‐6053 (2006) •

IM

Al‐Marhoobi

and

S

Kasapis,

Further

evidence

of

the

changing

nature

of

biopolymer

networks

in

the

presence

of

sugar, Carbohydrate Research, 340, 771‐774 (2005) •

S

Kasapis

and

IM

Al‐Marhoobi,

Bridging

the

divide

between

the

high‐

and

low‐solid

analyses

in

the

gelatin

/

k‐

carrageenan

mixture, Biomacromolecules,

6, 14‐23 (2005) •

S Kasapis, Definition of a

mechanical

glass

transition

temperature for dehydrated foods, Journal

of

Agricultural

and

Food Chemistry, 52, 2262‐2268 (2004)

2020

Assoc Professor KHOO Soo

BengPostdoc., University of Utah, 1984; Ph.D., University of Alberta, 1984;

B.Sc.

(Hons), Universiti Sains Malaysia, 1978

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khoosb.htm



specific focuses are:• Electrochemistry and electroanalytical

chemistry • Chemically modified electrodes


Super‐hydrophilicity

was

first

generated

purely

by

electrochemical

means

(in

the

absence

of

uv

illumination source) at the surface of a In2

O3

‐SnO2

electrode. This is achieved by the application

of high anodic potentials for a prolonged period. Such

surfaces

are

reversibly

converted back

to

their original hydrophobic state on storage (in air or in water).


J Premkumar, SB Khoo, Chemical Communications, 640‐642 (2005)•

B Yu, SB Khoo, Electrochemistry Communications, 4, 737‐742 (2002)•

SB Khoo, F Chen, Analytical Chemistry, 74, 5734‐5741 (2002)•

MR Khan, S. Khoo, Analytical Chemistry,

68, 3290‐3294 (1996)•

Q Cai, SB Khoo, Analytical Chemistry, 66, 4543‐4550 (1994)

2121

Assoc Professor KHOR EugenePh.D., Virginia Tech, 1983; B.Sc., Lakehead

Univ., 1979

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/khore.htm



Associate Editor, Biomaterials, 2005•

International Committee, 7th Asia Pacific Chitin Chitosan

Symposium, 2006

RESEARCH INTERESTSGeneral research interest lies on chitin and chitosan

for biomedical applications. Specific focuses

are:• Developing bone cement • Developing anticoagulant

RECENT HIGHLIGHTReference: Biomacromolecules, 6, 80‐87 (2005)

A

methodology

was

developed

to

produce

chitin

derivatives

under

homogeneous

conditions.

This

has

widespread

implications

for

producing

a

myriad

of

chitin

derivatives

for

various

applications.


Y

Zou

and

E

Khor,

Preparation

of

C‐6

Substituted

Chitin

Derivatives

under

Homogeneous

Conditions,

Biomacromolecules, 6, 80‐87 (2005)•

Z

Ge,

A‐S

Baguenard,

LY

Lim,

A

Wee

and

E

Khor,

Hydroxyapatite‐Chitin

Materials

as

Potential

Tissue

Engineered

Bone Substitutes,

Biomaterials, Britain, 25, 1049‐1058 (2004)•

E Khor

and LY Lim, Implantable Applications of Chitin and Chitosan, Biomaterials, Britain, 24 (13), 2339‐2349 (2003)

{Invited review}

2222

Assoc Professor LAI Yee HingPostdoc., Univ. of California at Berkeley and Lawrence Berkeley Laboratory,

1982; Ph.D., Univ. of Victoria, 1980; B.Sc., Nanyang

Univ. , 1978

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/laiyh.htm



specific focuses include:• Organic chemistry

RECENT HIGHLIGHTOur

research

interests

are

centred

mainly

on

the

studies

of

conjugated

aromatic

systems

going

from theoretically interesting molecules to organic materials for specific applications. A separate

effort focuses on the investigation of selected Chinese medicinal plants.


Y Cao, KS Yong, ZQ Wang, WS Chin, YH Lai, JF Deng and GQ Xu, Dry Thienylation

of the Silicon (111)‐(7 X 7) Surface,

J. Am. Chem. Soc., 122, 1812‐1813 (2000)•

W Huang, H Meng, W‐L Yu, J Pei, ZK Chen and Y‐H Lai, A Novel Series Of p‐n

Diblock

Light‐Emitting Copolymers

Based On Oligothiophenes

And 1,4‐Bis(Oxadiazolyl)‐2,5‐Dialkyloxybenzene, Macromolecules, 32, 118‐126 (1999)•

Y Cao, XM Wei, WS Chin, Y‐H Lai, JF Deng, SL Bernasek

and GQ Xu, of Di‐Sigma

Bond in Benzene Chemisorption

on

Si(111)‐7x7

, J. Phys. Chem. B, 103, 5698‐5702 (1999)•

HK

Yap,

XJ

Zuo,

M

Toyoda,

Y

Okada,

SG

Ang,

Y‐H

Lai,

JM

Matloff,

A

Marchevsky,

VS

Ramgolam

and

SC

Jordan,

Immunosuppressive Effect of the Hydrophobic Extract of a Chinese

Herb On Rat Lung Allograft Rejection, Transplant.

Proc., 30, 980‐981 (1998)

2323

Asst Professor LAM YulinB.Sc.(Hons), National Univ. of Singapore, 1987; Ph.D., National Univ. of

Singapore, 1992; Research Fellow, The Scripps Research Inst., 1992‐1994;

Research Fellow, Inst. of Molecular and Cell Biology,

1994‐1996

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lamyl.htm



interests

are

as

follows

(i)

Devising

new

synthetic

strategies

for

traceless

combinatorial

synthesis; (ii) synthesizing and screening libraries of compounds to search for biological activities;

and (iii) developing polymer‐bound reagents and catalysts. My

specific focuses include:• Traceless Solid‐phase Synthesis of Heterocycles

and Their Biological Evaluations as Anticonvulsants, DHFR Inhibitors, Human Multidrug

Resistance Protein 4 Inhibitors and Anti‐Hepatitis B Agents

• Polymer‐supported Reagents and Catalysts

RECENT HIGHLIGHTReference: Org. Lett., 8, 3283‐3285 (2006)

A

methodology

was

developed

to

produce

chitin

derivatives.

An

efficient

and

regioselective

procedure

for

the

synthesis

of

1,2,3‐triazoles

via

a

[3+2]

cycloaddition

of

polymer‐bound

vinyl

sulfone

and

sodium

azide

is

described.

Microwave

irradiation

provided

significant

rate

enhancement

in

all

steps

of

the

3‐steps

protocol.

A

representative

set

of

23

compounds

was

prepared.


T M C Tan, Y Chen, K H Kong, J Bai, Y Li, S G Lim, T H Ang and Y L Lam, Synthesis and the Biological Evaluation of

2‐Benzenesulfonylmethyl‐5‐Substituted‐Sulfanyl‐[1,3,4]‐Oxadiazoles

as

Potential

Anti‐Hepatitis

B

Virus

Agents,

Antiviral Res., 71, 7‐14 (2006)•

Y Gao

and Y L Lam, [3+2] Cycloaddition

Reactions in the Solid‐phase Synthesis of 1,2,3‐Triazoles, Org. Lett., 8, 3283‐

3285 (2006) •

C

H

Soh, W

K

Chui,

Y

L

Lam,

Efficient

Synthesis

of

2,4‐Disubsituted‐5‐Aminoimidazoles

Using

Microwave

Irradiation, J. Comb. Chem., 8, 464‐468 (2006) •

H Fu and Y L Lam, Traceless Solid‐Phase Synthesis of N1, N7‐Disubstituted Purines, J. Comb. Chem., 7, 734‐738 (2005) •

K

H

Kong,

Y

Chen,

X

Ma,

W

K

Chui

and

Y

L

Lam,

Traceless

Solid‐phase

Synthesis

of

Nitrogen‐containing

Heterocycles

and Their Biological Evaluations as Inhibitors of Neuronal Sodium Channels, J. Comb. Chem., 6, 928‐933

(2004)

Na+

SO

O- R1CH2X, 60oC or 100oC, DMF

R2CHO, piperidine orpiperidium acetate, THF or DMF, MW, 82oC or 111oC, 20min

NN

NNaN3, R3X, DIEA

SO O

R1

SO O

R1

R2R1 R2

MW,120oC, 20min

MW, 20min

R3

2424

Asst Professor Martin J LEARPostdoc., Tohoku Univ., 2000; Postdoc., Parke‐Davis & CNRS, 1997; Ph.D.,

Univ. of Glasgow, 1995; B.Sc., Univ. of Glasgow, 1991

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lear.htm



research

area

is

in

the

total

and

analogue

synthesis

of

natural

products

of

high

biological

relevance and structural complexity . Specific focuses are:• Total synthesis of natural antimalarial

(e.g.

bielschowskysin) and antibiotic (e.g.

platensimycin) leads

• Development of radiopharmaceuticals and peptide‐conjugate probes for disease detection and treatment


Y

Koyama,

MJ

Lear,

F

Yoshimura,

I

Ohashi,

T

Mashimo

and

M

Hirama,

Efficient

Construction

of

the

Kedarcidin

Chromophore

Ansamacrolide, Org. Lett., 7, 267‐270 (2005)•

T Usuki, T Mita, MJ Lear, P Das, K Akiyama, F Yoshimura, M Inoue, S Tero‐Kubota and M. Hirama, Spin‐Trapping of

13C‐Labeled

p‐Benzynes,

Generated

by

Masamune‐Bergman

Cyclization

of

Bicyclic

Nine‐Membered

Enediynes,

Angew. Chem., Int. Ed., 43 (6), 5249‐5253 (2004)•

P

Das,

T

Mita,

MJ

Lear

and

M

Hirama,

Synthesis

of

13C‐labelled,

Bicyclic

Mimetics

of

Natural

Enediynes,

Chem.

Commun., 2624‐2625 (2002)•

S Kobayashi, S

Ashizawa, Y Takahashi,

Y

Suigura,

M Nagaoka,

MJ Lear and

M

Hirama, The

First Total

Synthesis of

N1999‐A2: Absolute Stereochemistry and Stereochemical

Implications into DNA Cleavage, J. Am. Chem. Soc., 123 (45),

11294‐11295 (2001) •

MJ

Lear,

F

Yoshimura

and

M

Hirama,

A

Direct

and

Efficient

a‐Selective

Glycosylation

Protocol

for

the

Kedarcidin

Sugar, L‐Mycarose: AgPF6

as a Remarkable Activator of 2‐deoxythioglycosides, Angew. Chem., Int. Ed., 40

(5), 946‐949

(2001)

RECENT HIGHLIGHTReference: Ongoing work

@ http://staff.science.nus.edu.sg/~chmlmj/

Total

synthesis,

methodological

and

bioimaging

programmes

are

being

combined

in

order

to

develop new antimalarial, antibiotic, immunogenic, and biomedical agents and strategies.

2525

Dr Adrian M LEESingapore Millennium Found‐ation

Fellow, National Univ.. of Singapore, 2002‐

2004; Postdoc., Univ. of Cambridge, 2002; Ph.D., Univ. of Cambridge, 1997;

M.A., Univ. of Cambridge, 1996; B.A., Univ. of Cambridge, 1992

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/aml.htm



NASA Achievement Award, NASA, 1996

RESEARCH INTERESTSSpecific focuses are:• Assessment of the environmental impact and economic cost of the present behaviour

and the future evolution of tropospheric

ozone and other greenhouse gases• Development and application of fragment‐based methods to accurately describe the properties

and interactions of very large molecules, such as nucleic acids and proteins

RECENT HIGHLIGHTReference: J. Phys. Chem. A,

110, 8777–8785, (2006)

This

study

describes

an

algorithm

for

fragmenting

a

molecule

with

a

well‐defined

Kekulé

or

valence‐bond

structure

into

a

significant

number

of

smaller

fragment

molecules

that

are

more

amenable

to

high

level

quantum

chemical

calculations.

By

taking

an

appropriate

linear

combination of the fragment energies the study shows that it is possible in many cases to obtain

highly accurate total energies when compared to the total energy

of the full molecule. Using the

method described in this work it is in principle possible to obtain very accurate total energies of

systems

containing

hundreds,

if

not,

thousands

of

atoms

as

the

approach

is

subject

to

massive

parallelization

.


RPA Bettens and

AM Lee,

A new algorithm

for

molecular

fragmentation

in

quantum

chemical

calculations,

J.

Phys.

Chem. A, 110, 8777–8785 (2006)•

AM

Lee,

RL

Jones,

I

Kilbane‐Dawe

and

JA

Pyle,

Diagnosing

ozone

loss

in

the

extratropical

lower

stratosphere,

J.

Geophys. Res., 107,

doi:10.1029/2001JD000538 (2002)•

AM

Lee,

HK

Roscoe,

AE

Jones,

PH

Haynes,

EF

Shuckburgh,

MW

Morrey

and

HC

Pumphrey,

The

impact

of

the

mixing properties within the Antarctic stratospheric vortex on springtime ozone loss, J. Geophys. Res., 106,

3203–3211

(2001)•

HK

Roscoe,

AE

Jones

and

AM

Lee,

Midwinter

start

to

Antarctic

ozone

depletion:

Evidence

from

observations

and

models, Science, 278,

93–96 (1997)•

DJ

Wales and AM Lee, Structure and rearrangements of small trapped‐ion clusters, Phys. Rev. A, 47,

380–393 (1993)

Level-3 fragmentation of cis-3-hexanal presented in the form of an isodesmic

reaction, highlighting the underlying assumption of the method that ∆r

E = 0.

2626

Professor LEE Hian KeePh.D., Univ. of Canterbury, New Zealand, 1982; B.Sc., Univ. of Canterbury,

New Zealand, 1978

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leehk.htm



Editor, Analytica

Chimica

Acta, 2005 •

Member, Editorial Board, Journal of Chromatography A, 2004 •

Member, International Advisory Board, The Analyst, 1997 •

Member, Advisory Board, Analytical Sciences, 2004•

Member, Editorial Advisory Board, LCGC Asia Pacific, 2006•

Outstanding Researcher Award, NUS, 2006


major

interest

is

focused

on

the

development

and

applications

of

solvent‐minimized,

miniaturized

extraction

techniques,

particularly,

but

not

limited

to,

aqueous

environmental

matrixes. Specific focuses are:• Separation science; microextraction• Environmental analysis

RECENT HIGHLIGHTReference: Anal. Chem., 78, 2853‐2858 (2006)

In

this

work, multiwalled

carbon

nanotubes

were

held

within

a

polypropylene

membrane

envelope

(2

cm

x

1.5

cm)

and

used

as

adsorbent

for

the

extraction

organophosphorus

pesticides

from

sewage

sludge.


G Shen and HK Lee, Hollow fiber‐protected liquid‐phase microextraction

of triazine

herbicides, Anal. Chem.,

74, 648‐

654 (2002) •

Y He and HK Lee, Large‐volume sample stacking in acidic buffer for analysis of small organic and inorganic anions by

capillary electrophoresis, Anal. Chem., 71, 995‐1001 (1999) •

Y

Wang,

YC

Kwok,

Y

He

and

HK

Lee,

Application

of

dynamic

liquid‐phase

microextraction

to

the

analysis

of

chlorobenzenes

in water using a conventional microsyringe, Anal. Chem.,

70, 4610‐4614 (1998) •

W

Li

and

HK

Lee,

Use

of

triethylenetetraminehexaacetic

acid

combined

with

field‐amplified

sample

injection

in

speciation analysis by capillary electrophoresis, Anal. Chem., 70, 2666‐2675 (1998) •

Y He and HK Lee, Liquid‐phase microextraction

in a single drop of organic solvent using a conventional syringe, Anal.

Chem.,

69, 4634‐4640 (1997)

(b)

(a) Sample vial µ-SPE

Stir bar

C18 enclosed within HFM sheet (heat-sealed at open edges after folding)

Magnetic Stirrer

2727

Dr LEONG Lai PengPh.D., Univ. of Leeds, 2000; M.Sc., Univ. of Leeds, 1996; B.Sc., Universiti

Kebangsaan

Malaysia, 1995

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leonglp.htm


RESEARCH INTERESTSMain

interest

is

in

the

kinetics

of

chemical

reactions

especially

with

respect

to

bioactive

compounds

such

as

antioxidants

found

in

plants,

as

well

as

the

Maillard

reaction

in

foods

and

model systems. Specific focuses are:• Kinetics of antioxidant and free radical• Kinetic of Maillard

reaction

RECENT HIGHLIGHTReference: Food Chemistry, 99 (4), 775‐783 (2006)

The

paper

look

into

the

antioxidant

properties

of

aqueous

extracts

of

selected

plants

found

in

Singapore

market

and

their

potential

for

use

as

functional

food

ingredients. Antioxidants

from

these extracts can act synergistically to protect biomolecules

from being harmed


G

Shui

and

LP

Leong,

Residue

from

start

fruit

as

valuable

source

for

functional

food

ingredients

and

antioxidant

nutraceuticals, Food Chemistry

, 97(2), 277‐284 (2006) •

Wong SP, LP Leong and JHW Koh, Antioxidant activities of aqueous

extracts of selected

plants, Food Chemistry, 99(4),

775‐783 (2006)•

V

Thavasi,

LP

Leong

and

RPA

Bettens,

Investigation

of

the

influence

of

hydroxy

groups

on

the

radical

scavenging

ability of polyphenols, J. Physical Chemistry A, 110, 4918‐4923 (2006)•

G

Shui

and

LP

Leong,

Rapid

screening

and

characterisation

of

antioxidants

of

Cosmos

caudatus

using

liquid

chromatography

coupled

with

mass

spectrometry,

J.

Chromatography

B‐analytical

Technologies

In

The

Biomedical

And Life Sciences, 827(1), 127‐138 (2005)•

G Shui, and LP Leong, Screening of identification of antioxidants in biological samples using high‐performance liquid

chromatogtaphy‐mass spectrometry and its application on Salacca

edulis

Reinw, J. Agricultural and Food Chemistry, 53,

880‐886 (2005)

A2H

A2 A1

A1H

R

RH

Regeneration of an antioxidant (A1H) by a second antioxidant (A2H) after scavenging radical R•:

2828

Assoc Professor LEONG Weng KeePh.D., Simon Fraser Univ., 1995; M.Sc., National Univ. of Singapore, 1992;

M.A., Cambridge Univ., 1986; Dip. Ed., National Inst. of Education, 1985;

B.A., Cambridge, 1982

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/leongwk.htm



Visiting Professor, Kyoto University, 2006 •

Visiting Scientist, Cambridge University, 2005•

Visiting Scientist, ENSCP, 2002 and 2005•

Visiting Fellow, Tohoku University/JSPS, 2000

RESEARCH INTERESTSWe are interested in all aspects of organometallic

chemistry, ranging from synthesis to structure,

bonding,

reactivity

and

mechanistic

studies,

and

their

applications

in

catalysis

(homogeneous

and

heterogeneous),

nanomaterials

and

bioorganometallics.

We

are

interested

in

mononuclear,

dinuclear

as well as cluster compounds.

Specific focuses are:• Organometallic

chemistry ‐

synthesis, structure, bonding, reactivity, mechanisms, catalysis, materials

• Bioorganometallic

chemistry ‐

biopharmaceuticals, bioimaging, in vivo reactivity studies

RECENT HIGHLIGHTReference: J. Cluster Sci., 17, 111‐8 (2006)

The

synthesis

and

structural

characterization

of

two

novel

clusters,

Os6

(μ5

‐Sb)(μ‐H)2

(μ‐SbPh2

)(μ3

,η2‐

C6

H4

)(CO)17

and

Ru6

(μ5

‐Sb)(μ‐H)3

(CO)18

(SbPh3

)

are

presented. They are the first examples of osmium and

ruthenium clusters containing a naked μ5

‐Sb atom.


VS Sridevi, WK Leong and Y Zhu, Catalytic Reductive Coupling of 9‐Bromofluorene, Organometallics, 25, 283‐8 (2006) •

PK

Chan,

WK

Leong,

KI

Krummel

and

MV

Garland,

Aminoethyl‐Functionalised

Cyclopentadienyl

Iridium

Complexes: Photochemical C‐H Activation and Carbonylation

of Cycloalkanes, Eur. J. Inorg. Chem., 1568‐72 (2006) •

SY

Ng,

GK

Tan,

LL

Koh,

LY

Goh,

WK

Leong,

S

Ye

and

Y

Zhu,

Heterobimetallic

Ruthenium‐Cobalt

Complexes

Containing the Pentamethylcyclopentadienyl

or Indenyl

Ligand, Eur. J. Inorg. Chem., 663‐70 (2006) •

KH

Chan,

WK

Leong

and

KHG

Mak,

Thermolysis

of

the

Osmium‐Antimony

Clusters

Os3

(CO)11

(SbMe2

Ar):

Higher

Nuclearity

Clusters and Arrested Orthometallation, Organometallics,

25, 250‐9 (2006) •

P

Srinivasan

and

WK

Leong,

Reaction

of

the

Heteronuclear

Cluster

Cp*IrRu3

(μ‐H)2

(CO)10

with

Alkynes:

Stereoselective

Binding, Eur. J. Inorg. Chem., 464‐72 (2006)

2929

Professor LI Fong Yau SamD.Sc., Imperial College, 1998; Ph.D., Imperial College, 1984; B.Sc., Imperial

College, 1981

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lifys.htm



Outstanding Researcher Award, National University of Singapore/IMRE, 1999•

Dupont

Accomplishment Award, DuPont Company, 1993

RESEARCH INTERESTSAreas

of

research

interest

include

capillary

electrophoresis,

lab‐on‐chip

devices,

environmental

analysis,

biomedical

analysis,

bioimaging,

sensor

technologies,

lab‐on‐chip

devices,

nanomaterials

analysis,

chromatographic

techniques,

scanning

probe

microscopy,

supercritical

fluid extraction and chromatography. Specific focuses are:• Capillary electrophoresis• Environmental and biomedical analysis

RECENT HIGHLIGHTReference: Langmuir 18 (16): 6324‐6329 (2002)

We

developed

an

effective

generic

immobilization

platform

to

achieve

one‐step

direct

covalent

attachment

of

arrayed

proteins

with

good

reproducibility

and

uniformity.

We

also

show

that

the

approach

can

be

adapted

via

photolithography

to

produce

high‐density

protein

microarrays

for

simultaneous

parallel

biological assays.


WS

Law,

P

Kuban,

LL

Yuan,

JH

Zhao,

SFY

Li,

and

PC

Hauser,

Determination

of

tobramycin

in

human

serum

by

capillary electrophoresis with contactless

conductivity detection, Electrophoresis, 27(10), 1932‐1938 (2006)•

LJ

Yu

and

SFY

Li,

Dynamic

pH

junction‐sweeping

capillary

electrophoresis

for

online

preconcentration

of

toxic

pyrrolizidine

alkaloids in Chinese herbal medicine, Electrophoresis, 26(22), 4360‐4367 (2005) •

WS

Law,

JH

Zhao

and

SFY

Li,

On‐line

sample

enrichment

for

the

determination

of

proteins

by

capillary

zone

electrophoresis with poly(vinyl

alcohol)‐coated bubble cell capillaries, Electrophoresis, 26(18), 3486‐3494 (2005)•

Y

Xu,

WD

Qin,

YH

Lau

and

SFY

Li,

Combination

of

cationic

surfactant‐assisted

solid‐phase

extraction

with

field‐

amplified sample stacking for highly sensitive analysis of chlorinated acid herbicides by capillary zone electrophoresis,

Electrophoresis, 26 (18), 3507‐3517 (2005)•

LJ Yu, Y Xu, HT Feng and SFY Li, Separation and determination of

toxic pyrrolizidine

alkaloids in traditional Chinese

herbal medicines by micellar

electrokinetic

chromatography with organic modifier, Electrophoresis, 26(17), 3397‐3404

(2005)

Scanning tunneling microscopy of surface morphology of human IgG

molecules on protein arrays produced by direct covalent attachment.

3030

Assoc Professor LI TianhuPostdoc., Scripps Research Institute, 1994; Ph.D., State Univ. of New York,

1992; M.Sc., Beijing Inst. of Chemical Technology, 1982; B.Sc., Jilin Univ.,

1980

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lth.htm


RESEARCH INTERESTSMy specific focuses include:• Nuclear acid chemistry

RECENT HIGHLIGHTThe primary focus of my group in recent years has been directed toward the exploration of new

properties

of

G‐quadruplex

and

i‐motif

as

well

as

their

diagnostic

and

therapeutic

applications.

Several

circularly

unimolecular

and

bimolecular

G‐quadruplex

and

i‐motif

have

accordingly

been

made

in

our

lab

in

the

past

years

while

preparation

of

fluorescence‐tagged

circular

G‐

quadruplex

and

i‐motif

are

currently

in

progress.

We

hope

that

circular

G‐quadruplex

and

i‐

motif

could

be

useful

molecular

tools

for

interfering

certain

biological

functions

of

tetraplex‐

binding

proteins

and

for

examining

the

winding

and

resolving

mechanisms

of

G‐quadruplex

catalyzed by G‐quadruplex‐promoting and disintegrating proteins.


D

Liu,

J

Chen,

AHF

Lee,

LMC

Chow,

ASC

Chan

and

TH

Li,

Small

Circular

Oligodeoxynucleotides

Achieved

from

Self‐Assembling Entities, Angew. Chem., Int. Ed. Engl., 42(7), 797‐799, (2003)•

AHF

Lee,

ASC

Chan and TH Li,

Synthesis

of

5‐(7‐hydroxyheptyl)‐1,2‐dithiolan‐3‐one

1‐oxide,

a

core

functionality

of

antibiotic leinamycin, Tetrahedron, 59, 833‐839, (2003)•

J

Qi,

T.

Li

and

ASC

Chan,

Fungicide

chinomethionate

as

a

new

family

of

photoinducible

DNA‐cleaving

agens,

Bioorganic & Medicinal Chemistry Letters, 13(20), 3561‐3563, (2003)•

AHF

Lee,

J

Chen,

D

Liu,

TYC

Leung,

ASC

Chan

and

TH

Li,

Acid‐Promoted

DNA‐Cleaving

Activities

and

Total

Synthesis of Varacin

C, Journal of the American Chemical Society, 124(47), 13972‐13973, (2002)•

AHF

Lee,

ASC

Chan

and

TH

Li,

Acid‐accelerated

DNA‐cleaving

activities

of

antitumor

antibiotic

varacin,

Chemical

Communications, 18,

2112‐2113, (2002)

3131

Asst Professor LIU XiaogangPostdoc., Massachusetts Inst of Tech, 2006; Ph.D., Northwestern Univ, 2004;

M.Sc., East Carolina Univ, 1999; B.Sc., Beijing Tech and Business Univ, 1996

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/liuxg.htm


RESEARCH INTERESTSMy general interests are supramolecular

chemistry, materials science, and bioinorganic chemistry.

Specific focuses are:• Controlling assemblies of dynamically interacting biological molecules • Understanding of relations between structure and physical properties


JM

Soon,

CW

Lim,

KP

Loh,

et

al,

Initial‐stage

oxidation

mechanism

of

Ge(100)2x1

dimers,

Phys. Rev. B.,

72, 115343 (2005) •

Liu,

S

Guo

and

CA

Mirkin,

Surface

and

Site‐Specific

Ring‐Opening

Metathesis

Polymerization

Initiated

by

Dip‐Pen

Nanolithography, Angew. Chem. Int. Ed. Engl., 42, 4785 (2003)•

J‐M Nam, MA Ratner, X Liu and CA Mirkin, Single‐Walled Carbon Nanotubes

and C60

Encapsulated by a

Molecular

Macrocycle, J. Phys. Chem. B., 107, 4705 (2003)•

X Liu, CL Stern and Mirkin, Chemical Origami: Formation of Flexible 52‐Membered Tetranuclear

Metallacycles

via a

Molecular Square Formed from a Hemilabile

Ligand, Organometallics, 21, 1017 (2002)•

M Su, X Liu, S‐Y Li, VP

Dravid

and CA

Mirkin,

Moving

Beyond

Molecules:

Patterning Solid‐State

Features via

Dip‐

Pen Nanolithograpy

with Sol‐Based Inks, J. Am. Chem. Soc., 124, 1560 (2002)

3232

Assoc Professor LOH Kian PingPostdoc., National Inst. for Material Science, Tsukuba, Japan, 1998; Ph.D.,

Oxford Univ., 1996; B.Sc., National Univ. of Singapore, 1994

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/lohkp.htm



Co‐chair of Engineering Conference International (ECI), ECI conference series, 2007•

Advisory Panel of Nanodiamond

and Nanocarbon

Conference, First Conference, Osaka, 2006•

Senior Adjunct scientist, Institute of Materials Research and Engineering, 2006‐07

RESEARCH INTERESTSSpecific focuses are:• Diamond Surface Science and Diamond Biosensors• Nanomaterials

and Self‐assembly of Molecular Films

RECENT HIGHLIGHTReference: J. Applied Physics, 99, 104309 (2006)

Chemisorption

of

atoms

on

the

single

walled

Boron

Nitride

nanotube

with

a

particular

chiral

pattern

can

produce

perturbations

which

are

coupled

to

the

band

gap

and

affect

the

electronic

polarization. The largest perturbation to electronic Hamiltonian

is produced by pairwise

H‐H or

H‐F chemisorption

on B‐N chains along the wrapping axis. This causes most significant lowering

of

tip

work

function,

and

induces

negative

electron

affinity

on

Boron‐tipped

end

of

the

Boron

Nitride Nanotube.


JM

Soon,

CW

Lim,

KP

Loh,

et

al,

Initial‐stage

oxidation

mechanism

of

Ge(100)2x1

dimers,

Phys. Rev. B.,

72, 115343 (2005) •

HR

Gu, Su

X

and

KP

Loh,

Electrochemical

impedance

sensing

of

DNA

hybridization

on

conducting

polymer

film‐

modified diamond, J. Phys. Chem. B, 109, 13611‐13618 (2005 )•

W Chen, L Wang, C Huang, KP Loh and ATS Wee, Effect of functional group (fluorine) of aromatic thiols

on electron

transfer at the molecule‐metal interface

,

Journal of the American Chemical Society., 128, 935‐939 (2006)•

M

Lin,

JPY

Tan,

C

Boothroyd,

KP

Loh,

ES

Tok

and

YL

Foo,

Direct

observation

of

single‐walled

carbon

nanotube

growth at the atomistic scale, Nano

Letters,

6, 449‐452 (2006) •

T

Ouyang,

XY

Gao,

DC

Qi,

KP

Loh

et.

al.,

Cycloadditions

on

diamond(100)

2x1:

Observation

of

lowered

electron

affinity due to hydrocarbon adsorption, J. Phys. Chem. B, 110, 5611‐5620 (2006)

3333

Asst Professor LU YixinPostdoc., Nagoya Univ., 2001; Postdoc., Clinical Research Inst. of Montreal,

2000; Ph.D., McGill Univ., 2000; B.Sc., Fudan

Univ., 1991

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/luyx.htm



study

Asymmetric

organocatalysis/Green

Chemistry/Medicinal

Chemistry.

Specific

focuses

are:• Hydrophobic organocatalyst‐promoted asymmetric reactions in water• Development of analgesics, anti‐cancer agents and antibiotics

RECENT HIGHLIGHTReference: Chem. Commun., 2801 (2006)

The

natural

tryptophan

was

shown

to

be

able

to

catalyze

the

direct

aldol

reactions

between

various cyclic ketones

and aromatic aldehydes

in water with high enantioselectivity.


Y Lu, TK Lum, YWA Leow, G Weltrowsak, TM‐D Nguyen, C Lemieux, NN Chung and PW Schiller, Replacement of

the N‐terminal Tyrosine

Residue

in Opioid

Peptides with 3‐(2,6‐

Dimethyl‐4‐carbamoylphenyl)propanoic Acid (Dcp)

Results in Novel Opioid

Antagonists,

J. Med. Chem.,

49, 5382 (2006)•

Z Jiang, Z Liang, X Wu and Y Lu, Asymmetric Aldol

Reactions Catalyzed by Tryptophan

in Water,

Chem. Commun.

2801 (2006)•

Y

Lu,

TM‐D

Nguyen,

G

Weltrowska,

I

Berezowska,

C

Lemieux,

NN

Chung

and

PW

Schiller,

[2ʹ,6ʹ‐

Dimethyltyrosine]Dynorphin

A(1‐11)‐NH2

Analogues

Lacking

an

N‐Terminal

Amino

Group:

Potent

and

Selective

Opioid

Antagonists, J. Med. Chem., 44, 3048 (2001)•

Y

Lu

and

G

Just,

Stereoselective

Synthesis

of

RP

‐

and

SP

‐

Dithymidine

Phosphorothioates

Using

Chiral

Indolo‐

oxazaphosphorine

Intermediates Derived from Tryptophan, Angew. Chem. Int. Ed., 39, 4521 (2000)•

M

Manoharan,

Y

Lu,

MD

Casper

and

G

Just,

Allyl

Group

as

a

Protecting

Group

for

Internucleotide

Phosphate

and

Thiophosphate

Linkages

in

Oligonucleotide

Synthesis:

Facile

Oxidation

and

Deprotection

Conditions,

Org.

Lett.,

2,

243‐246 (2000)

R2

O

R1 H

O

R

OH

R1

O

R2 R+ L-Tryptophan

H2O, RT

up to 96% ee

3434

Dr MAK Ka Wai KarenPostdoc., Hong Kong Univ. of Science and Tech., 2004; Ph.D., Hong Kong Univ.

of Science and Tech., 2003; B.Sc., Hong Kong Univ. of Science and Tech., 1999

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/mak.htm


RESEARCH INTERESTSSpecific focuses are:• Enzyme sensors for environmental analysis • Substrate recycling in multienzyme

system


KKW Mak, AWC Law, S Tokuda, H Yanase

and R Renneberg, Application of cyanide hydrolase

from Klebsiella

sp. in

biosensor system for detection of low‐level cyanide, Appl

Microbiol

Biotechnol

, 67, 631‐636 (2005) •

KKW Mak, H Yanase

and R Renneberg, Novel optical biotest

for determination of cyanide traces in marine fish using

microbial cyanide hydratase

and formate

dehydrogenase, Microchimica

Acta, 149, 131‐135 (2005) •

RCH

Kwan,

PYT

Hon,

KKW

Mak

and

R

Renneberg,

Amperometric

Determination

of

Lactate

with

Novel

Trienzyme/Poly(carbamyol) Sulfonate

Hydrogel‐based Sensor, Biosensors and Bioelectronics, 19, 1745‐1752 (2004) •

KKW

Mak,

U

Wollenberger,

F

Scheller

and

R

Renneberg,

An

amperometric

bi‐enzyme

sensor

for

determination

of

formate

using cofactor regeneration, Biosensors and Bioelectronics, 18, 1095‐1100 (2003) •

SCK Lau, KKW Mak, F Chen and P Qian, Bioactivity of bacterial strains isolated from marine biofilms

in Hong Kong

Waters for the induction of larval settlement in the marine polychaete

Hydroides

elegans, Mar Ecol Prog

Ser, 226: 301‐

310

(2002)

3535

Dr MAUNG MAUNG SawPh.D., National Univ. of Singapore, 2006; M.B.B.S., Inst, of Medicine (1),

Yangon, 1992

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/maung.htm



National Consultant, Nuclear Medicine Section, Division of Human

Health, International

Atomic Energy Agency (IAEA), 2005‐06 •

Expert on Radiopharmacy, Nuclear Medicine Section, Division of Human Health,

International Atomic Energy Agency (IAEA), 2002‐06

RESEARCH INTERESTSMajor

interest

is

on

“Bioorganometallic

Chemistry”

with

emphasis

on

the

development

of

radiopharmaceuticals

and

probes

for

“molecular

imaging

and

therapy”

(from

bench‐top,

translational

medicine

to

clinical

trial).

There

is

minor

focus

on

organometallic‐based

drugs,

biosensors and nano‐devices for diagnosis and therapy.

Specific focuses are:• Bioorganometallic

Chemistry• Molecular Imaging and Therapy

RECENT HIGHLIGHTReference: doi:10.1016/j.ica.2006.04.023

The synthesis

and

characterization

of

new

fac‐{M(CO)3}+

(M

=

Tc, Re)

based

complexes

with

bi‐

and

tridentate

ligands

and

a

pendant

C18

chain

is

described.

Due

to

the

lipophilicity

of

the

complexes they are potential surrogates for Lipiodol, a liver cancer therapy agent. The complexes

are very stable which makes them suitable for application in radioimaging

and –therapy.


MM S, P Kurz, N Agorastos, TSA Hor, FX Sundram, YK Yan and

R

Alberto, Complexes with

the

fac‐{M(CO)3

}+ (M = 99mTc, Re) moiety and long alkyl chain ligands

as Lipiodol

surrogates, Inorg. Chim. Acta, 359(12), 4087‐4094 (2006) •

FX Sundram,

TCM Chau,

P Onkhuudai, P Bernal

and AK Padhy, Eur. J. of Nucl. Med. & Mol. Imaging, 2(31), 250‐257

(2004) •

FX

Sundram,

SW

Yu,

JM

Jeong,

S

Somanesan,

J

Premaraj,

MM

Saw

and

B.S.

Tan,

Ann.

Acad.

Med.

Singapore,

30(5),

542‐5 (2001)

3636

Asst Professor David G POPOVICHPostdoc., NSERC, Vancouver 2005; Postdoc., Univ. of British Columbia, 2004;

Ph.D., Univ. of British Columbia, 2004; M.Sc., Univ. of Toronto, 1996; B.Sc.,

Univ. of Toronto, 1991

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/popovich.htm



specific focuses are:• Bioactive plant foods and extracts derived from natural health products and traditional food sources

• Dietary saponins

from ginseng (ginsenosides), bitter melon and soy)

RECENT HIGHLIGHTReference: Phytochemistry, 65, 337‐344 (2004)

Ginsenosides

Rh2 and Rg3 are rare bioactive

ginsenosides

and were effectively shown to be a

breakdown product of thermal extraction of

ginseng plant material, an underutilized resource,

and is potential source for natural health products

or pharmaceutical development


DG Popovich and DD Kitts, Phytochemistry, 65, 337‐344 (2004)•

DG Popovich and DD Kitts, Arch.Biochem Biophys, 406, 1‐8 (2002)•

DG Popovich and DD Kitts, J. Biochem. Mol. Toxicol, 18(3), 143‐149, (2004)•

DG Popovich and DD Kitts, Can. J. Physiol. Pharmacol,

82, 183–190 (2004)•

DJ Jenkins,

DG

Popovich, CW Kendall, E Vidgen, N Tariq, TPP

Ransom,

TMS

Wolever,

V

Vuksan,

CC

Mehling,

DL

Boctor, C Bolognesi, J Huang and R Patten, Metabolism,

46(6), 1‐4 (1997)

3737

Dr SHIP Chee PingPostdoc., Ghent Univ., 2003; Ph.D, Univ. of Southampton, 2002; B.Sc.(Hons),

Univ. of Malaya, 1997

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/shipcp.htm


RESEARCH INTERESTSGeneral interests include Heterogeneous Catalysis, Small Peptide Synthesis.

Specific focuses are:• Replacement of homogeneous liquid acids such as HF and H2

SO4

by heterogeneous solid acids• Cyclic dipeptides


CP

Ship,

A

Zainudin

and YY Lim, Effects

of

aminocarboxylate

ligands

of

surface

active

copper(II)

complexes

on

the

hydrolysis of p‐Nitrophenyldiphenylphosphate,

J.Colloid

and

Interface Science, 217, 211 (1999)•

T

Campbell,

JM

Corker,

AD

Dent,

SA

EL‐Safty,

J

Evans,

SG

Fiddy,

MA

Newton,

CP

Ship

and

S

Turin,

Synthesis,

characterization and chemistry of transition metals in mesoporous

silica, Stud. Surf. Sci. Catal., 132, 667 (2001)

3838

Asst Professor SIM Wee SunPostdoc., Univ. of Cambridge, 1997; Ph.D., Univ. of Cambridge, 1996; B.Sc.

(Honours), National Univ. of Singapore, 1992

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/simws.htm



DuPont Young Faculty Award, DuPont, 2001 •

SNAS Young Scientist Award, Singapore National Academy of Science/A*STAR, 2002


aim

to

establish

viable

methods

of

functionalizing

surfaces

and

gaining

molecular‐level

understanding

and

control

of

chemical

transformations

occurring

at

the

interfaces

of

solid

materials used in catalysis, microelectronics and nanotechnology. Specific focuses are:• Surface Science and Catalysis• Thin Films and Nanomaterials

RECENT HIGHLIGHTReference: Langmuir, 22, 7861 (2006)

A

two‐step

surface

functionalization

approach

has

been

used

to

encase

Au

nanoparticles

in

monolayer

organometallic

Ru‐complex

shells

by

the

reaction

of

an

intermediate

surface‐bound

mercaptopropanoic

acid capping species with Ru

dodecacarbonyl

(Ru3

(CO)12

) clusters.


WS

Sim

and

DA

King,

Surface‐Bound

Ketenylidene

(CCO)

from

Acetone

Decomposition

on

Ag{111}‐p(4

x

4)‐O,

Journal of the American Chemical Society, 117, 10583 (1995) •

WS

Sim,

P

Gardner

and

DA

King,

Surface‐Bound

Helical

Polyacetaldehyde

Chains

and

Bidentate

Acetate

Intermediates on Ag{111}, Journal of the American Chemical Society, 118, 9953 (1996) •

F Tao, WS Sim, GQ Xu and MH Qiao, Selective Binding of the Cyano

Group in Acrylonitrile

Adsorption on Si(100)‐2x1,


WS

Sim,

TC

Li,

PX

Yang

and

BS

Yeo,

Isolation

and

Identification

of

Surface‐Bound

Acetone

Enolate

on

Ni(111),


BS

Yeo,

ZH

Chen

and

WS

Sim,

Surface

Functionalization

of

Ni(111)

with

Acrylate

Monolayers,

Langmuir,

19,

2787

(2003)

Ru

Ru

Ru

CO

COCO

CO

CO

COOC

OC

CO

CO

OC CO

+Au

S

CO

O

S

C

OO

S

C

OO

SC

O

O

S CO

O

SC

O

O

S

COO

S

C O

O

S

COO

S

CO

SC

O

O S

COO Ru

Ru

COCO

CO

CO

Ru

Ru

CO

CO

COCO

Ru

Ru

COOC

OC

OC

Ru

Ru

OC

OC

OCCO H

OH

H

H

AuAu

S

C

OO

S

CO

O

S

CO O

SC

O

O

SC

O

O

SC

OO

S

CO

S

C OO

S

COO

S

CO

SC

O

OS

COO

O

O

H

H

H

HH

H

H

H

H

HH

H

3939

Asst Professor TAN Choon HongPostdoc., Harvard Univ., 2002; Ph.D., Univ. of Cambridge, 1999; B.Sc.

(Honours), National Univ. of Singapore, 1996

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tanch.htm



are

interested

in

Bronsted

base

catalyzed

enantioselective

reactions.

We

are

particularly

interested

in

the

chiral

bicyclic

guanidines.

We

have

shown

that

they

can

catalyze

Michael

and

Diels‐Alder reactions with high enantioselectivities. Specific focuses are:• Chiral

bicyclic

guanidine catalyzed Michael and Diels‐Alder reactions• Enantioselective

Baylis‐Hilman

reaction


W Ye, J Xu, CT Tan and C‐H Tan, 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD) catalyzed

Michael reactions, Tetrahedron

Letters, 46, 6875‐6878 (2005)•

W

Ye,

D

Leow,

SLM

Goh,

CT

Tan,

CH

Chian

and

C‐H

Tan,

Chiral

bicyclic

guanidines:

a

concise

and

efficient

aziridine‐based synthesis, Tetrahedron Letters, 47, 1007‐1010 (2006)•

J

Xu,

Y

Guan,

S

Yang,

Y

Ng,

G

Peh,

C‐H

Tan,

Chiral

Imidazoline

Promoted

Asymmetric

Baylis‐Hillman

Reaction.

Chemistry ‐

An Asian Journal, In press•

J

Shen,

TT

Nguyen,

Y‐P

Goh,

W

Ye,

X

Fu,

J

Xu,

C‐H

Tan,

Chiral

Bicyclic

Guanidine

Catalyzed

Enantioselective

Reactions of Anthrones. Journal of the American Chemical Society, In press

RECENT HIGHLIGHTChiral

bicyclic

guanidine

was

found

to

be

an

excellent

catalyst

for

reactions

between

anthrones

and

various

dienophiles.

The

catalyst

can

tolerate

a

range

of

substituents

and

substitution

patterns on the anthrone. This is the first case of highly enantioselective

base catalyzed anthrone

Diels‐Alder reaction.

NO

OPh

Cl

OH

ClS

SNH

N

NBn BnO

Cl Cl

N

O

O

Ph

3iCH2Cl2, -20 oC, 4 hrs92% yield, 99% ee

(10 mol%)1

2c

+

4040

Asst Professor TOH Chee SengPostdoc., California Inst. of Technology, 2004; Ph.D., Univ. of Southampton,

2002; M.Sc., National Univ. of Singapore, 1995; B.Sc. (Hons), National Univ.

of Singapore, 1993

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tohcs.htm


RESEARCH INTERESTSOur

current

research

interests

are

in

nano‐scale

and

molecular

level

analyses

using

electrochemical methods whereby interfacing materials which interact directly with analytes

play

significant

roles. At

these

levels,

the

physico‐chemical

nature

of

elements

at

the

interface

functioning

as

signal

transducers

in

the

case

of

sensors

or

facilitating

selective

partition

in

the

case

of

chromatography

stationary

phases

will

become

increasingly

crucial

to

overall

performance of analytical techniques. Specific focuses are:• Using nanoporous

alumina as our ‘backbone’

for integrating biological molecules onto this physically nanostructured

and chemically inert system• Transport behaviours

of proteins and extend the same understanding to nanoscale

level separations of biomolecules

with the aim of achieving molecular level analysis


GW Koh, S Agarwal and CS Toh, Development of a membrane‐based electrochemical immunosensor, submitted•

GW

Koh,

S

Agarwal,

PS

Cheow

and

CS

Toh,

Characterization

of

the

barrier

layer

of

nanoporous

alumina

films

prepared using two different contact configurations, Electrochim. Acta, in print•

CS

Toh,

An

Experiential

Research

Focused

Approach:

Implementation

in

a

Non‐Laboratory

Based

Graduate‐Level

Analytical Chemistry Course, J. Chem. Ed., in print•

L He and CS Toh, Recent Advances in Analytical Chemistry – A Material Approach, Anal. Chim. Acta, 556, 1–15 (2006) •

LY Liu and CS Toh, Chemical modification of nanoporous

alumina membranes, US patent pending, International PCT

Application No. PCT/SG2006/000183

RECENT HIGHLIGHTReference: Anal. Chim. Acta, 556, 1–15 (2006)

Advancements of materials research have profound direct impacts on developments in analytical

chemistry and may hold the key to improvement

of existing

or

new

techniques at

present

times

and

near

future.

This

work

reviews applications

of

materials in

analytical

chemistry,

with

focus

on

sensors,

separations

and

extraction

techniques.

A

broad

spectrum

of

materials

classified

as

hybrids,

nanomaterials

and

biomolecular

materials

were

surveyed

as

examples

of

interesting

works carried out in the last five years.

4141

Assoc Professor VALIYAVEETTIL SureshPostdoc., Max‐Planck Inst. for Polymer Research, 1997; Postdoc., Univ. of

Twente, 1992; Ph.D., Univ. of Victoria, 1992; M.Tech., Indian Inst. of

Technology, 1987; M.Sc., Calicut Univ., 1985; B.Sc., Calicut Univ., 1983

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/suresh.htm


RESEARCH INTERESTSMy specific focuses are:• Organic/Polymer materials • Bio(nano)materials

and nanotechnology

RECENT HIGHLIGHTReference: Angewandte

Chem., 44, 5476‐5479 (2005)

Structure‐property

relationship

of

a

series

of

designer

peptides

towards

the

biomineralization

process is investigated using various experimental techniques.


M Vetrichelvan

and S Valiyaveettil, Chem. Eur. J., 11, 5889‐5898 (2005)•

PK

Ajikumar,

S

Vivekanandan,

R

Laxminarayanan,

SDS

Jois,

RM

Kini

and

S

Valiyaveettil,

Angewandte

Chem.,

44,

5476‐5479 (2005)•

S Jegadesan, RC Advincula

and S Valiyaveettil, Nanolithographic, Advanced Materials, 17, 1282‐1285 (2005)•

R Lakshminarayanan

, EC Ooi, XJ Loh, RM Kini

and S Valiyaveettil, Biomacromolecules,

6(3),

1429‐1437 (2005)•

R Lakshminarayanan, RM Kini

and S Valiyaveettil, PNAS,

99(8), 5155‐5159 (2002)

4242

Assoc Professor Jagadese

J VITTALPostdoc., Univ. of Western Ontario, 1987; Ph.D., Indian Inst. of Science, 1982;

M.Sc., Madurai Univ., 1977; B.Sc., Univ. of Madras, 1975

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/jjvittal.htm



Associate Editor, Journal of Synthesis and Reactivity in Inorganic, Metal‐Organic and Nano‐Metal

Compounds, (A Taylor and Francis Journal), 2006‐present•

Member, Editorial Boards of Main Group Metal Chemistry

(from 2003), Molecular and

Supramolecular

Chemistry (from 2007), and Current Chemical Biology

(from 2007) •

ISCAS Bronze Medal 2001 of the Indian Association of Solid State

Chemists and Allied

Scientists, India for contributions in the field of Solid State Chemistry, 2001•

DAAD‐NUS Exchange Visit Fellowship to Göttingen, Germany, June‐July, 2002 •

Royal Society of Chemistry Journal Grant Award for International

Authors, 2002

RESEARCH INTERESTSCrystal

engineering

of

hydrogen‐bonded

and

coordination

polymeric

architectures,

photochemistry

and

solid‐state

structural

transformations

involving

coordination

polymers,

chemistry

of

metal

chalcogenocarboxylates

as

molecular

precursors

for

metal

chalcogenide

materials, thin films and nanocrystals. Specific focuses are:• Inorganic chemistry & Inorganic materials• Supramolecular

chemistry & Crystal Engineering

RECENT HIGHLIGHTReference: Angew. Chem. Int. Ed.,

45, 4337‐4341 (2006)

A

solvated

linear

1D

coordination

polymer

containing

4,4’‐bipyridylethylene

has

no

parallel

dispositions

of

C=C

bonds

in

the

crystal

structure

but

undergoes

photodimerization

due

to

the

lateral

movements

of

adjacent

linear

strands

on

desolvation

forming

a

ladder‐like structure.


M

Nagarathinam

and

JJ

Vittal,

Anisotropic

Movements

of

Coordination

Polymers

upon

Desolvation:

Solid‐state

Transformation

of

Linear

1D

Coordination

Polymer

to

Ladder‐like

Structure,

Angew.

Chem.

Int.

Ed.,

45,

4337‐4341

(2006) •

NL Toh, M Nagarathinam and JJ Vittal, Topochemical

photodimerization

in the molecular ladder metal coordination

polymer

[{(CF3

CO2

)(μ‐O2

CCH3

)Zn}2

(μ‐bpe)2

]n

(where

bpe

=

4,4’‐bipyridylethelene)

via

single‐crystal

to

single‐crystal

transformation, Angew. Chem. Int. Ed.,

44, 2237‐2241 (2005) •

B

Sreenivasulu

and

JJ

Vittal,

Helix

inside

a

Helix:

Encapsulation

of

Hydrogen‐bonded

Water

Molecules

inside

a

Staircase Coordination Polymer, Angew. Chem. Int. Ed., 43, 5769‐5772 (2004) •

MT Ng, CB Boothroyd

and JJ Vittal, One Pot Synthesis of New Phase AgInSe2

Nanorods, J. Am. Chem. Soc.

, 128, 1178‐

1179 (2006) •

MT

Ng,

C.

Boothroyd

and

JJ

Vittal,

Shape

and

size

control

of

Ag2

Se

nanocrystals

from

single

precursor

[(Ph3

P)3

Ag2

(SeC{O}Ph)2

], Chem. Commun., 3820‐3822 (2005)

4343

Dr WENG ZhiqiangPh.D., National Univ. of Singapore, 2003; B.Sc., Fuzhou Univ., 1994

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wengzq.htm



specific focuses are:• Transition metal catalysts for olefin oligomerization/ polymerization • Transition metal catalysts for organic synthesis

RECENT HIGHLIGHTReference: Organometallics, 23, 4342 (2004)

A mixture of Pd2

(dba)3

and hemilabile

ferrocenyl

ligand

[η‐C5

H4

CH=N(C6

H5

)]Fe[η‐C5

H4

P(t‐Bu)2

],

efficiently catalyzes the Suzuki

cross‐couplings of a range of arylboronic

acids and aryl chlorides,

affording the desired biaryl

products in high isolated yields. One of catalytically active 14‐e linear

Pd(0)

intermediate,

Pd{[η‐C5

H4

CH=N(C6

H5

)]Fe[η‐C5

H4

P(t‐Bu)2

]}2

,

has

been

isolated

and

crystallographically

established.


Z Weng, S Teo, LL Koh, TSA Hor, Angew. Chem. Int. Ed.,

44, 7560 (2005)•

Z Weng, S Teo, LL Koh, TSA. Hor, Organometallics, 23, 4342 (2004)•

Z Weng, S Teo, LL Koh, TSA. Hor, Organometallics

,

23, 3603 (2004)•

Z Weng, LY Goh, Acc. Chem. Res., 37, 187 (2004)•

LY. Goh, Z Weng, WK Leong and JJ Vittal, J. Am. Chem. Soc., 124, 8804 (2002)

4444

Asst Professor Thorsten WOHLANDPostdoc., Stanford Univ.; Ph.D., Swiss Federel

Inst. of Technology at Lausanne;

Dipl. Phys., Univ. of Heidelberg

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/tw.htm



group

works

on

the

development

of

new

fluorescence

spectroscopy

techniques

for

the

measurement of biomolecular

interactions in cells, tissues, and organisms. Specific focuses are:• Techniques: Single wavelength excitation fluorescence cross‐correlation spectroscopy (SW‐FCCS)

and EMCCD based fluorescence correlation spectroscopy• Biological systems: Transmembrane

protein receptors and peptides and their interaction with membranes (e.g. epidermal growth factor receptor, antimicrobial peptides)


L

Yu,

JL

Ding,

B

Ho

and

T

Wohland,

Investigation

of

a

Novel

Artificial

Antimicrobial

Peptide

by

Fluorescence

Correlation

Spectroscopy:

An

Amphipathic

Cationic

Pattern

is

Sufficient

for

Selective

Binding

to

Bacterial

Type

Membranes and Antimicrobial Activity, BBA Biomembranes, 1716, 29‐39 (2005)•

L

Yu,

M

Tan,

B

Ho,

JL

Ding

and

T.

Wohland,

Determination

of

critical

micelle

concentrations

and

aggregation

numbers by fluorescence correlation spectroscopy: Aggregation of

a lipopolysaccharide, Analytica

Chimica

Acta, 556

(1), 216‐225 (2006) •

LC

Hwang,

M

Leutenegger,

M

Gösch,

T

Lasser,

P

Rigler,

W

Meier

and

T

Wohland,

Prism‐based

multicolor

fluorescence correlation Spectrometer, Optics Letters, 31(9), 1310‐1312 (2006) •

LC Hwang, M Gösch, T Lasser

andT

Wohland, Simultaneous multicolor fluorescence cross‐correlation spectroscopy to

detect higher order molecular interactions using single wavelength laser excitation, Biophys. J., 91, 715‐727 (2006) •

B

Kannan,

JY

Har,

P

Liu,

I

Maruyama,

JL

Ding

and

T

Wohland,

EMCCD‐camera

based

fluorescence

correlation

spectroscopy, Anal. Chem., 78(10), 3444‐51 (2006)

RECENT HIGHLIGHTReference: Biophys. J., 91, 715‐727 (2006)

Single

wavelength

fluorescence

cross‐correlation

spectroscopy

(SW‐FCCS)

can

determine

interaction

patterns

between

multiple

binding

partners.

The

effectiveness

of

SW‐FCCS

to

detect

binding of three interacting partners is experimentally verified

in this publication.

4545

Assoc Professor WONG M W RichardPostdoc., Yale Univ., 1991; Postdoc., IBM Kingston, 1990; Ph.D., Australian

National Univ.y, 1989; B.Sc. & B.Math, Univ. of Newcastle, 1985

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/wongmw.htm



International Board member, Asian Pacific Association on Theoretical and Computational

Chemistry, 2005•

Outstanding Researcher Award, National University of Singapore, 2002•

Australian Research Fellow, Australian Research Council, 1992‐1997

RESEARCH INTERESTSComputational

quantum

chemistry,

weak

intermolecular

interactions,

organocatalysis,

free

radical

chemistry,

sulfur

chemistry,

molecular

sensors,

reaction

mechanism,

reactive

intermediates, gas‐phase ion chemistry, computational vibrational

spectroscopy, solvation

theory.

Specific focuses are:• Mechanistic study of catalyzed asymmetric organic reactions and design of novel organocatalysts

• Study of weak intermolecular interactions (CH…O, CH… π, π‐π, π*‐π*) in chemistry and biology; molecular recognition; and design of novel chemical

sensors

RECENT HIGHLIGHTReference: Chem. Eur. J., 12 (2006) in print

The

omnipresent

π*‐π*

bonding

interaction

plays

a

crucial

role

in

understanding

the

structures

and conformations of all binary sulfur‐rich oxides.


MW Wong, Prediction of a Metastable

Helium Compound: HHeF, J. Am. Chem. Soc.,

122, 6289‐6290 (2000) •

MW Wong, Quantum‐Chemical Calculations of Sulfur‐Rich Compounds, Top. Curr. Chem., 231, 1‐30 (2003) •

MW

Wong,

On

the

Roles

of

C‐H….O=S

and

p‐stacking

Interactions

in

2‐Bromoacrolein

Complex

with

N‐tosyl‐(S)‐

tryptophan

Derived Oxazaborolidinone

Catalyst, J. Org. Chem., 70, 5487‐5493 (2005) •

J

Ran

and

MW

Wong,

Saturated

Hydrocarbon‐Benzene

Complexes:

A

Theoretical

Study

of

Cooperative

CH/π

Interaction, J. Phys. Chem. A, 110, 9702‐9709 (2006) •

MW Wong, Y Steudel

and R Steudel, Structures and Vibrational

Spectra of the Sulfur‐Rich Oxides SnO (n

= 4‐9). The

Importance of π*‐π* Interaction, Chem. Eur. J.,

12 in print (2006)

4646

Professor XU Guo QinPostdoc., Univ. of Toronto, 1991; Postdoc., Brookhaven National Lab, 1989;

Ph.D., Princeton Univ., 1987; B.Sc., Fudan

Univ., 1982

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xugq.htm



specific focuses are:• Surface chemistry• Nano‐materials and molecular conductivity

RECENT HIGHLIGHTReference: Accounts of Chemical Research, 37(11), 882‐893 (2004)

Molecular attachment chemistry is emerging as an important approach to tailor the chemical,

physical and mechanical properties of silicon surfaces as well as for incorporating organic

functions into silicon‐based devices for various technological needs. This article reviews the

recent progress and current understanding of reactivity, selectivity and mechanisms of organic

molecules on Si(111)‐7×7.


F Tao, ZH Wang, YH Lai and GQ Xu, Journal of The American Chemical Society, 125(22), 6687‐6696, (2003)•

F Tao, XF Chen, ZH Wang and GQ Xu, Journal of The American Chemical Society, 124(24), 7170‐7180 (2002)•

F Tao, WS Sim, GQ Xu GQ and MH Qiao, Journal of The American Chemical Society, 123(38), 9397‐9403 (2001)•

Y Cao, ZH Wang, DF Deng and GQ Xu, Angewandte Chemie‐International Edition, 39(15), 2740‐2743 (2000)•

Y

Cao,

KS

Yong,

ZQ

Wang,

WS

Chin,

YH

Lai,

JF

Deng,

GQ

Xu,

Journal

of

The

American

Chemical

Society,

122(8),

1812‐1813 (2000)

4747

Asst Professor XU Qing‐HuaPostdoc., UC Santa Barbara, 2005; Postdoc., Stanford Univ., 2002; Ph.D., UC

Berkeley, 2001; B.Sc., Zhejiang

Univ., 1993

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xuqh.htm


RESEARCH INTERESTSWe are interested in the development and application of novel temporally and spatially resolved

optical

spectroscopic

methods

to

study

low‐dimensional

materials,

biomacromolecules

and

fundamental

chemical

processes,

to

understand

their

structure‐dynamics‐function

relationship.

Specific focuses are:• Nonlinear optics and laser spectroscopy• Materials physics and biophysics


Q‐H Xu, S Wang, D Korystov, A Mikhailovsky, GC Bazan,

D

Moses and

AJ Heeger, Fluorescence

Resonance Energy

Transfer Gate in DNA Sequence Detection: a Time‐Resolved Study, PNAS, 102, 530‐535 (2005) •

Q‐H Xu, BS Gaylord,

S Wang, GC Bazan,

D

Moses

and

AJ

Heeger,

Time‐resolved

energy

transfer

in

DNA

sequence

detection using water‐soluble conjugated polymers: the role of electrostatic and hydrophobic interactions, PNAS, 101

11634‐11639 (2004) •

KA Merchant, Q‐H Xu, DE Thompson, and MD Fayer, Frequency Selected Ultrafast

Infrared Vibrational

Echo Studies

of Liquids, Glasses and Proteins, J. Phys. Chem. A, 106, 8839‐8849 (2002) •

Q‐H Xu, Y‐Z Ma and GR Fleming, Different Real and Imaginary Components of Third‐Order Polarization Revealed by

Optical Heterodyne Detected Tranient

Grating Spectroscopic Studies in Crystal Violet: Model and Experiments, J.Phys.

Chem. A., 106, 10755‐10763 (2002) •

Q‐H

Xu,

Y‐Z

Ma

and

GR

Fleming,

Heterodyne

Detected

Transient

Grating

Spectroscopy

in

Resonant

and

Non‐

resonant Systems Using a Simplified Diffractive Optics Method, Chem. Phys. Lett., 338, 254‐262 (2001)

RECENT HIGHLIGHTReference: Chem. Comm, submitted

Nanocomposites

consisting of a

metal

core,

a

silica‐spacer

shell

with

controlled

thickness,

and

a

dye‐labelled

shell

were

synthesized

and

separation

distance

dependent

fluorescence

enhancement of fluorescein

isothiocyanate

by silver nanoparticles

was studied.

4848

Asst Professor XUE FengPostdoc., The Wistar

Institute, 2005; Ph.D., The Chinese Univ. of Hong Kong,

2000; B.Sc., Tsinghua

Univ., 1993

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/xf.htm


RESEARCH INTERESTSMy specific focuses are:• Crystal engineering, supramolecular

chemistry• Protein crystallography, structural biology

RECENT HIGHLIGHTReference: J. Am. Chem. Soc., 122, 9860‐9861 (2000)

The design and construction of hydrogen‐bonded ʺsupramolecular

rosettesʺ from guanidinium

/

organic

sulfonate,

trimesic

acid,

or

cyanuric

acid

/

melamine

depend

on

utilization

of

their

topological

equivalence,

i.e.,

equal

numbers

of

donor

and

acceptor

hydrogen‐bonding

sites

and

C3 symmetry of the component moieties .


C‐K Lam, F Xue, J‐P Zhang, X‐M Chen and TCW Mak, J. Am. Chem. Soc., 127, 11536‐11537 (2005)•

R Thaimattam, F Xue, JARP Sarma

and TCW Mak, G.R. Desiraju, J. Am. Chem. Soc., 123, 4432‐4445 (2001)•

TCW Mak

and F Xue, J. Am. Chem. Soc., 122, 9860‐9861 (2000)•

F Xue and TCW Mak, Acta Crystallogr.

B, 56, 142‐154 (2000)•

F Xue

and TCW Mak, J. Phys. Org. Chem., 13, 405‐414 (2000)

4949

Assoc Professor YAO Shao

QinPostdoc., Scripps Research Institute, 2001; Postdoc., Univ. of California

Berkeley, 1999; Ph.D., Purdue Univ., 1998; B.Sc., Ohio State Univ., 1993

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yaosq.htm



Scientific Advisory Board,

Molecular BioSystems,

2005 •

Young Research Award, National University of Singapore, 2005 •

Young Investigator Award, A*STAR Singapore, 2002

RESEARCH INTERESTS“Catalomics”

‐

We

are

interested

in

developing

powerful

strategies

in

Chemical

Biology

and

Chemical

Proteomics

that

enable

organism‐wide,

high‐throughput

studies

of

enzymes.

Specific

focuses are:• Chemical Biology• Medicinal Chemistry


By using “Click Chemistry”, we report the facile synthesis of various affinity‐based hydroxamate

probes

that

enable

generation

of

activity‐based

fingerprints

of

a

variety

of

metalloproteases,

including matrix metalloproteases

(MMPs), in proteomics experiments.


R

Srinivasan,

M

Uttamchandani

and

SQ Yao, Rapid assembly and

in situ

screening of bidentate

inhibitors of

protein

tyrosine phosphatases

(PTPs), Org. Lett., 8, 713‐716 (2006) •

Y

Hu,

GYJ

Chen,

SQ

Yao,

Activity‐based

high‐throughput

screening

of

enzymes

using

DNA

microarray,

Angew.

Chem. Intl. Ed., 44, 1048‐1053 (2005) •

EWS Chan, S Chattopadhaya, RC Panicker, X Huang, SQ Yao, Developing photo‐active affinity probes for proteomic

profiling: hydroxamate‐based probes for metalloproteases, J. Am. Chem. Soc., 126, 14435‐14446 (2004) •

GYJ

Chen,

M

Uttamchandani,

Q

Zhu,

G

Wang

and

SQ

Yao,

Developing

a

strategy

for

activity‐based

detection

of

enzymes in a protein microarray, ChemBiochem, 4, 336‐339 (2003) •

ML Lesaicherre, RYP Lue, GYJ Chen, Q Zhu and SQ Yao, Intein‐mediated biotinylation

of proteins and its application

in a protein microarray, J. Am. Chem. Soc., 124, 8768‐8769 (2002)

5050

Assoc Professor YIP Hon Kay JohnPostdoc., Caltech, 1997; Postdoc., Technical Univ. of Munich, 1995; Ph.D.,

Univ. of Hong Kong, 1993; B.Sc., Univ. of Hong Kong, 1989

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/yipjohn.htm


RESEARCH INTERESTSMy general interests lie on

supramolecular

chemistry and

physical inorganic

chemistry.

Specific

focuses are:• Self‐assembly and dynamics of metallosupramolecular

systems • Design and Synthesis of Luminescent Metal Complexes and molecular wires

RECENT HIGHLIGHTReference: Inorganic Chemistry (2006) In press

This work shows the presence of

a

dynamic

equilibrium

between

silver‐metallacyles

and

helical

polymers in solution. A ring opening mechanism is proposed for the exchange in acetonitrile.


JHK

Yip,

J

Wu,

K‐Y

Wong,

KP

Ho,

CS‐N

Pun

and

JJ

Vittal,

Electronic

Communication

Mediated

by

Pt‐Pt

s‐bond,

Organometallics, 21, 5292‐5233 (2002)•

R Lin, JHK Yip, K Zhang, LL Koh, KY Wong, KP Ho, Self‐assembly and Molecular Recognition of a Luminescent Gold

Rectangle, J. American Chemical Society, 126, 15852‐15869 (2004)•

K Zhang, J Prabhavathy, JHK Yip, LL Koh, GK Tan, JJ Vittal, First Examples of AuI‐X‐AgI

Halonium

Cations

(X = Cl‐

and Br‐), J. American Chemical Society, 125, 8452‐8453 (2004)•

S.

Muthu, JHK Yip and JJ Vittal,

Coordination

Networks

of

Ag(I)

and

N,N’‐

Bis(3‐Pyridinecarboxamide)‐1,6‐Hexane:

Structures and Anion Exchange, J. Chem. Soc., Dalton Trans, 4561‐4568 (2002)•

JHK

Yip

and

J

Prabhavathy,

A

Luminescent

Gold

Ring

That

Flips

Like

Cyclohexane,

Angewandte

Chemie

International Edition

, 40, 2159 –

2162 (2001)

Ag3 ring Ag4 ring helical polymer

5151

Asst Professor ZENG HuaqiangPostdoc., UC Santa Barbara, 2005; Postdoc., Stanford Univ., 2002; Ph.D., UC

Berkeley, 2001; B.Sc., Zhejiang

Univ., 1993

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zenghq.htm


RESEARCH INTERESTSThe

central

theme

in

our

research

group

is

focused

on

the

applications

of

broadly

defined,

bioinspired

Supramolecular

Chemistry

to

address

many

challenging

issues

at

the

interface

of

chemistry and biology. Specific focuses are:• Synthetic ion channels• High‐throughput screening systems widely suitable for discovering highly efficient, stereoselective

catalysts of varying kinds for catalyzing wide‐ranging chemical transformations• Catalytic drugs that can catalytically cleave any chosen disease‐causing proteins


H Zeng, J

Xie

and

PG

Schultz,

Genetic

introduction

of

a

diketone‐containing

amino

acid

into

proteins,

Bioorg.

Med.

Chem. Lett., 16, 5356‐5359 (2006) •

H Zeng, X Yang, B Gong, etc, An extremely stable, self‐complementary hydrogen‐bonded duplex. Chem. Commun., 13,

1556–1557 (2003) •

B

Gong,

H

Zeng,

J

Zhu,

etc,

Creating

nanocavities

of

tunable

sizes:

Hollow

helices.

Proc.

Natl.

Acad.

Sci.

USA,

99,

11583‐11588 (2002) •

H Zeng,

X Yang, RA

Flowers,

II

and B Gong,

A

Non‐Covalent

Approach to

Anti‐Parallel β‐Sheet

Formation, J. Am.

Chem. Soc., 124, 2903‐2910 (2002) •

H

Zeng,

RS

Miller,

RA

Flowers,

II

and

B

Gong,

A

Highly

Stable,

Six‐Hydrogen‐Bonded

Molecular

Duplex,

J.

Am.

Chem. Soc., 122, 2635‐2644 (2000)

RECENT HIGHLIGHTReference: Proc. Natl. Acad. Sci. USA, 99, 11583‐11588 (2002)

To

capture

Nature’s

astonishing

ability

in

creating

sophisticated

folding

biopolymers

with

nanosized

cavities,

we

have

developed

a

general

strategy

for

designing

folded

structures

with

modifiable

outer

surfaces

and

easily

tunable

interior

cavities,

which

may

find

important

applications in catalysis, separation & molecular recognition, etc.

5252

Dr ZHAO JinPh.D., Technological Univ. of Munich, 2005; M.Sc., Chinese Academy of

Science, 1995; B.Sc., Liaoning

Univ., 1992

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zhaoj.htm


RESEARCH INTERESTSGeneral interest falls on Organometallic

chemistry and catalysis. Specific focuses are:• Organometallic

chemistry of metals with high oxidation state and their application in oxidation catalysis

• Nickel and chromium complexes and their application in selective catalytic oligomerisation

of ethylene


M Zhou, J

Zhao, J

Li,

S Yue, C Bao, J

Mink,

S Zang

and

FE Kühn,

MTO

Schiff

Base

Complexes:

Synthesis,Structures

and Catalytic Application in Olefin Epoxidation, Chem. Eur. J., accepted (2006) •

J

Zhao,

E

Herdtweck

and

FE

Kühn,

Chiral

ansa‐bridged η5‐

Cyclopentadienyl

Molybdenum

Complexes:

Synthesis,

Structure and Application in Asymmetric Olefin Epoxidation, , J. Organomet. Chem., 691,

2199‐2206 (2006) •

J Zhao, A Sakthivel, AM Santos and FE Kühn, Cyclopentadienyl‐Molybdenum Complexes with a Siloxane

Functional

Group as Models for Efficient Hetrogeneous

Epoxidation

Catalysts, Inorg. Chim. Acta,

358, 4201‐4207 (2005) •

A

Sakthivel,

J

Zhao,

M

Hanzlik,

AST

Chiang,

WA

Herrmann

and

FE

Kühn,

Heterogenization

of

organometallic

molybdenum complexes with siloxane

functional groups and their catalytic application, Adv. Synth. Catal., 347,

473‐

483 (2005) •

J

Zhao,

AM

Santos,

E

Herdtweck

and

FE

Kühn,

Molybdenum

and

Tungsten

Complexes

of

Composition

(η5‐

C5

R5

)MR’(CO)3

and Their Use as Olefin Epoxidation

Catalyst Precursors, J. Mol. Catal. A. Chem., 222, 265‐271 (2004)

RECENT HIGHLIGHTReference: Chem. Eur. J., (2006) accepted

Several

Schiff

base

ligands

form

readily

complexes

with

methyltrioxorhenium(VII)

(MTO),

undergoing

a

H‐transfer

from

a

ligand

bound

OH‐group

to

a

ligand

N

atom.

The

catalytic

behavior

of

epoxidation

of

olefins

is

influenced

significantly

by

the

Schiff

bases

coordinated

to

the MTO moiety.

OH

NHC

R' ReO

OOH3C

ROH

NHC

R'

RRe

CH3

O OO

+Diethyl ether

r.t.

R'= H,R= H (1); R'= H, R= p-CH3 (2); R'= H, R= p-Cl (3); R'= H, R= p-OCH3 (4); R'= -OCH3;R= p-CH3 (5)

5353

Assoc Professor ZHOU WeibiaoPostdoc., Univ. of Waterloo, 1991; Ph.D., Univ. of Queensland, 1991; M.Eng,

Chinese Academy of Sciences, 1985; B.Sc., Beijing Univ. of Chemical

Technology, 1982

http://www.chemistry.nus.edu.sg/ourpeople/academic_staff/zhouwb.htm



Member, International Editorial Board, International Journal of Food Engineering (USA), 2004

onwards •

Member, International Editorial Board, Food Manufacturing Efficiency (UK), 2006 onwards •

Appointed Member of the Nominations Advisory Committee, International Union of Food

Science & Technology (IUFoST), 2001‐2003, 2003 ‐2006 •

Member‐at‐large, Executive Committee, International Society of Food Engineering (ISFE), 2006

onwards


interests

lie

on

food

processing

and

food

engineering;

particularly

baking

processes,

dairy

processes, food process modelling

and optimisation,

advanced

process

control,

and

the effect

of

food

processing

on

some

functional

components

such

as

isoflavones

and

antioxidants.

Specific

focuses are:• Modeling, optimisation, and advanced control of food processes• Effect of processing on functional components of food

RECENT HIGHLIGHTReference: J. Food Engineering, 77(4), 784‐791 (2006)

The

robustness

of

a

Computational

Fluid

Dynamics

(CFD) model for bread baking to some uncertainties

in

the

physical

properties

of

dough/bread

is

addressed

in

this

paper.

Temperature

profiles

at

eight

different

locations

in

bread

and

oven

were

analyzed.

Analysis

of

the

experimental

results

showed

that

density

and

heat

capacity

were

the

more influential factors.


MK Mya, W Zhou and CO Perera, A study of the mass transfer in osmotic dehydration of coated potato cubes, Journal

of Food Engineering, 77(1), 84‐95 (2006)•

R

Wang,

and

W

Zhou,

Stability

of

tea

catechins

in

the

breadmaking

process,

Journal

of

Agricultural

and

Food

Chemistry, 52(26), 8224‐8229 (2004) •

W

Zhou,

Application

of

FDM

and

FEM

to

solving

the

simultaneous

heat

and

moisture

transfer

inside

bread

during

baking, International Journal of Computational Fluid Dynamics, 19(1), 73‐77 (2005) •

W

Zhou,

S

Dong,

and

PL

Lee,

Exponential

Tracking

with

Disturbance

Attenuation

(ETDA)

by

Output

Feedback,

Computers & Chemical Engineering, 26(9), 1231‐1239 (2002) •

N Therdthai

and W Zhou, Artificial Neural Network Modelling

of the Electrical Conductivity Property of Recombined

Milk, Journal of Food Engineering, 50(2), 107‐111 (2001)

Velocity profile in the oven by CFD

5454

HONOURS STUDENT COHORT 2006

5555

GRADUATE STUDENT COHORT 2006

56 56 highlights...2 2 emeritus professor ang how ghee emeritus professor huang hsing hua emeritus...

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