蛋白質相關介紹
DESCRIPTION
蛋白質相關介紹. 大綱. 蛋白質交互作用與複合體 各種編號 資料庫介紹 工具介紹. 蛋白質交互作用與複合體. 蛋白質會彼此結合在一起而形成蛋白質複合體 (protein complex) 以執行特殊功能。 蛋白質的結合稱作蛋白質與蛋白質交互作用 (protein-protein interactions;PPI) 。 許多學者研究蛋白質複合體是從圖論的觀點出發,主要是相互作用網路中密度高之區域極可能是蛋白質複合體 。 目前尚未有其他先進探討蛋白質複合體中內部的關連性,故本文對真實的複合體做了密度和連通度的驗證 。. 蛋白質間交互作用相關研究. - PowerPoint PPT PresentationTRANSCRIPT
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(protein complex) (protein-protein interactions;PPI)
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(protein-protein interaction)(protein-protein interaction network)
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Gene IDUniportProtein GI604P41182gi7289529759P56524gi259016348
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:BOND (protein GI)MIPS (Uniprot) and (Gene ID or Entrez ID)NCBIBiogrid (Gene ID or Entrez ID)DIPGene Ontology (GO)GNSBLASTNCBI - Batch
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BONDBONDGO653 Go AnnotatorDB Cross ReferenceBONDGO
BINDIDGIGOIDGOName1282445059113677DNA binding1282445059115524ATP binding1282445059115634nucleus1282445059116281DNA repair1282445059116298mismatch repair1282445059116355regulation of transcription, DNA-dependent12824450591145786negative regulation of cell cycle
BINDIDGIGOIDGOName1282445059113677DNA binding1282445059115524ATP binding1282445059115634nucleus1282445059116281DNA repair1282445059116298mismatch repair1282445059116355regulation of transcription, DNA-dependent12824450591145786negative regulation of cell cycle
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BOND()
:http://bond.unleashedinformatics.com/Action?pg=1001
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BOND()
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BOND()
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BOND()
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Mips
: http://mips.helmholtz-muenchen.de/genre/proj/corum/
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Mips()
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Mips(EX)Mips;;;;uniport ID();Gene ID()1;BCL6-HDAC4 complex;;Human;P41182P56524;604 9759;
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DIPDIP
edge idnode A idnode A GUE idnode A SwissProt idnode A PIR idnode AGI codenode B idnode B GUE idnode B SwissProt idnode B PIR idnode BGI codeDIP:18671EDIP:17012NSkp1pP3499116777215DIP:17013NCul1pQ136163139077DIP:44805EDIP:17012NSkp1pP3499116777215DIP:27532NIkBbetaQ15653703118DIP:44780EDIP:139NIkBalphaP25963A3993510092619DIP:17012NSkp1pP3499116777215
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:http://dip.doe-mbi.ucla.edu/dip/Main.cgi
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NCBI
:http://www.ncbi.nlm.nih.gov/
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NCBI
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BioGridBioGrid BioGridDIP
:http://thebiogrid.org/download.php
:9606
INTERACTOR_AINTERACTOR_BOFFICIAL_SYMBOL_AOFFICIAL_SYMBOL_BALIASES_FOR_AALIASES_FOR_BEXPERIMENTAL_SYSTEMSOURCEPUBMED_IDORGANISM_A_IDORGANISM_B_IDEG1134EG1146CHRNA1CHRNGACHRA|ACHRD|CHRNA|CMS2A|FCCMS|SCCMSACHRG|MGC133376InvitroKreienkamp HJ (1995)769591096069606EG70EG7454ACTCWASCMD1R|ACTC1IMD2|THC|WASPInvivoScott MP (2002)1202908896069606EG2039EG70EPB49ACTCDMTCMD1R|ACTC1InvivoKhanna R (2002)1201142796069606
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BioGrid
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Gene OntologyGO Molecular FunctionBiological Process Cellular Component
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Gene Ontology
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GO format function processcomnpentdefs
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Homo sapiens GO Annotations
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GNS:NCBI:Blast:
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GNS
http://bioagent.iis.sinica.edu.tw/GeneAlias/#
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How to UseA. Search Methods (1) FullText
MySQL FullText 1. 2.
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(2) Exact Match
1. (Id)
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(3) Blurred Match
1.
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B. Search Hints
(1)
1. , (A2MAACS)
(2)
1.
2. 20000
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Select Batch Search
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Batch Search
Column Selected
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Selected : Uniprot/Swissprot.txt
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Upload Text Data File
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Results
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NCBI-batch
Select the database : GeneUpload the text filePress the retrieve button
http://www.ncbi.nlm.nih.gov/sites/batchentrez?db=Nucleotide
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Protein-andDatabaseProtein
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FASTA
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Blast()1.C C:\ncbi-blastn\2.(blast-2.2.13-ia32-win32)3. [NCBI] Data="C:\ncbi-blast\data"4.ncbi.inic:\WINDOWS
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Blast()5.(blast-2.2.13-ia32-win32.exe)6.Path;c:\ncbi-blastNCBI Blastn
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Blast146490NCBI Blastblastp
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Blast()batfasta
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Blast():Format->Score->1-6bat
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