蛋白質相關介紹

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蛋蛋蛋蛋蛋蛋蛋

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蛋白質相關介紹. 大綱. 蛋白質交互作用與複合體 各種編號 資料庫介紹 工具介紹. 蛋白質交互作用與複合體. 蛋白質會彼此結合在一起而形成蛋白質複合體 (protein complex) 以執行特殊功能。 蛋白質的結合稱作蛋白質與蛋白質交互作用 (protein-protein interactions;PPI) 。 許多學者研究蛋白質複合體是從圖論的觀點出發,主要是相互作用網路中密度高之區域極可能是蛋白質複合體 。 目前尚未有其他先進探討蛋白質複合體中內部的關連性,故本文對真實的複合體做了密度和連通度的驗證 。. 蛋白質間交互作用相關研究. - PowerPoint PPT Presentation

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  • (protein complex) (protein-protein interactions;PPI)

  • (protein-protein interaction)(protein-protein interaction network)

  • Gene IDUniportProtein GI604P41182gi7289529759P56524gi259016348

  • :BOND (protein GI)MIPS (Uniprot) and (Gene ID or Entrez ID)NCBIBiogrid (Gene ID or Entrez ID)DIPGene Ontology (GO)GNSBLASTNCBI - Batch

  • BONDBONDGO653 Go AnnotatorDB Cross ReferenceBONDGO

    BINDIDGIGOIDGOName1282445059113677DNA binding1282445059115524ATP binding1282445059115634nucleus1282445059116281DNA repair1282445059116298mismatch repair1282445059116355regulation of transcription, DNA-dependent12824450591145786negative regulation of cell cycle

    BINDIDGIGOIDGOName1282445059113677DNA binding1282445059115524ATP binding1282445059115634nucleus1282445059116281DNA repair1282445059116298mismatch repair1282445059116355regulation of transcription, DNA-dependent12824450591145786negative regulation of cell cycle

  • BOND()

    :http://bond.unleashedinformatics.com/Action?pg=1001

  • BOND()

  • BOND()

  • BOND()

  • Mips

    : http://mips.helmholtz-muenchen.de/genre/proj/corum/

  • Mips()

  • Mips(EX)Mips;;;;uniport ID();Gene ID()1;BCL6-HDAC4 complex;;Human;P41182P56524;604 9759;

  • DIPDIP

    edge idnode A idnode A GUE idnode A SwissProt idnode A PIR idnode AGI codenode B idnode B GUE idnode B SwissProt idnode B PIR idnode BGI codeDIP:18671EDIP:17012NSkp1pP3499116777215DIP:17013NCul1pQ136163139077DIP:44805EDIP:17012NSkp1pP3499116777215DIP:27532NIkBbetaQ15653703118DIP:44780EDIP:139NIkBalphaP25963A3993510092619DIP:17012NSkp1pP3499116777215

  • :http://dip.doe-mbi.ucla.edu/dip/Main.cgi

  • NCBI

    :http://www.ncbi.nlm.nih.gov/

  • NCBI

  • BioGridBioGrid BioGridDIP

    :http://thebiogrid.org/download.php

    :9606

    INTERACTOR_AINTERACTOR_BOFFICIAL_SYMBOL_AOFFICIAL_SYMBOL_BALIASES_FOR_AALIASES_FOR_BEXPERIMENTAL_SYSTEMSOURCEPUBMED_IDORGANISM_A_IDORGANISM_B_IDEG1134EG1146CHRNA1CHRNGACHRA|ACHRD|CHRNA|CMS2A|FCCMS|SCCMSACHRG|MGC133376InvitroKreienkamp HJ (1995)769591096069606EG70EG7454ACTCWASCMD1R|ACTC1IMD2|THC|WASPInvivoScott MP (2002)1202908896069606EG2039EG70EPB49ACTCDMTCMD1R|ACTC1InvivoKhanna R (2002)1201142796069606

  • BioGrid

  • Gene OntologyGO Molecular FunctionBiological Process Cellular Component

  • Gene Ontology

  • GO format function processcomnpentdefs

  • Homo sapiens GO Annotations

  • GNS:NCBI:Blast:

  • GNS

    http://bioagent.iis.sinica.edu.tw/GeneAlias/#

  • How to UseA. Search Methods (1) FullText

    MySQL FullText 1. 2.

  • (2) Exact Match

    1. (Id)

  • (3) Blurred Match

    1.

  • B. Search Hints

    (1)

    1. , (A2MAACS)

    (2)

    1.

    2. 20000

  • Select Batch Search

  • Batch Search

    Column Selected

  • Selected : Uniprot/Swissprot.txt

  • Upload Text Data File

  • Results

  • NCBI-batch

    Select the database : GeneUpload the text filePress the retrieve button

    http://www.ncbi.nlm.nih.gov/sites/batchentrez?db=Nucleotide

  • Protein-andDatabaseProtein

  • FASTA

  • Blast()1.C C:\ncbi-blastn\2.(blast-2.2.13-ia32-win32)3. [NCBI] Data="C:\ncbi-blast\data"4.ncbi.inic:\WINDOWS

  • Blast()5.(blast-2.2.13-ia32-win32.exe)6.Path;c:\ncbi-blastNCBI Blastn

  • Blast146490NCBI Blastblastp

  • Blast()batfasta

  • Blast():Format->Score->1-6bat

    *